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Paulozzi Leonard J LJ the Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, - - 2014
Purpose: The purpose of this study was to examine trends in frequency and daily dosage of opioid use and related adverse health outcomes in a commercially insured population. We examined medical claims from the Truven Health MarketScan commercial claims database for 789,457 continuously enrolled patients ages 18 to 64 years ...
Moon Karam K Division of Neurological Surgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona, - - 2014
Clinical outcomes of methamphetamine users with aneurysmal subarachnoid hemorrhage (aSAH) are unknown. To analyze differences in presentation, in-hospital morbidity, and outcomes between methamphetamine users and non-users. All 472 patients included in the Barrow Ruptured Aneurysm Trial from 2003 to 2007 were reviewed. Patients with 1- and 3-year follow-up were included ...
Larsen Torben Bjerregaard TB Department of Cardiology, Atrial fibrillation Study group, Aalborg University Hospital, Denmark; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, - - 2014
The bleeding risk among patients withatrial fibrillation is higher early after initiating therapy with vitamin K antagonists (VKA). Evidence is limited on how prior VKA-experience affects bleeding risk when initiating novel oral anticoagulant therapy.Weinvestigated this among patientswith atrial fibrillationinitiating dabigatran therapy. Using nationwide Danish prescription and patient registries, we identified ...
Lange Jakob J Ypsomed AG, Burgdorf, - - 2014
This article presents a late-stage formative usability study of a pen-injector platform device. Such devices are used for the subcutaneous delivery of biopharmaceuticals, primarily for self-administration by the patient. The study was conducted with a broad user population, defined to represent user characteristics across a range of indications. The goals ...
Khullar Shilpa S Department of Physiology, ESIC Dental College and Hospital, Sector-15, Rohini, Delhi, 110089 India ; E-605, First Floor, Greater Kailash Part-2, New Delhi, 110048 - - 2013
There has been a manifold increase in the number of mobile phone users throughout the world with the current number of users exceeding 2 billion. However this advancement in technology like many others is accompanied by a progressive increase in the frequency and intensity of electromagnetic waves without consideration of ...
Blanco José Ramón - - 2013
Objectives: Current antiretroviral guidelines state that being older than 50 to 55 years of age is an indication to start antiretroviral therapy (ART), regardless of CD4 status. However, no references to the preferred combination ART (cART) for these patients have been described. Our study compares emtricitabine and tenofovir disoproxil fumarate ...
Khajotia Rumi - - 2013
Case study A man, 33 years of age, presented to his family physician with complaints of acute breathlessness and right-sided chest pain for the past 2 days. He had smoked 20 cigarettes daily for the past 15 years, and had also smoked 4-5 marijuana spliffs per week for the past ...
Jefferson Delroy A - - 2013
Anecdotal reports suggest that cannabis users require increased postoperative analgesia but there is insufficient supporting data. A prospective randomized study was carried out in 73 patients undergoing elective operations. Postoperatively, all patients were assessed by a blinded investigator, who recorded pain intensity, sedation levels, mood, and hourly analgesia requirements. We ...
Schmidt Thomas - - 2013
Statins have pleiotropic properties that may affect the development of connective tissue diseases (CTD). The objective of this study was to compare the risk of CTD diagnoses in statin users and nonusers. This study was a propensity score-matched analysis of adult patients (30 to 85 years old) in the San ...
Salehimarzijarani Babak - - 2013
Background/aims:Gastrointestinal disorders are important side effects of aspirin therapy, even if the low-dose enteric-coated form is administered. The aim of the current study was to present the upper and lower endoscopic features of patients with gastrointestinal hemorrhage using low-dose enteric-coated aspirin. Materials and Methods: This prospective study was conducted among ...
Hung Hung-Chang - - 2013
The echocardiographic findings, microbiological profiles, risk factors for mortality, and outcomes of intravenous drug (IVD) users and non-users with infective endocarditis (IE) in Taiwan were evaluated. In this retrospective study, the charts of IVD users and non-users who were treated for IE between January 1999 and December 2009 in a ...
Ho C W - - 2013
BACKGROUND: Poor adherence to gastroprotective agents (GPAs) is common among users of nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (ASA). There are little data on the utilization of GPAs among NSAID and ASA users complicated by ulcer bleeding. AIM: To study the utilization of GPA among NSAID and ASA ulcers ...
Glemne Maria - - 2013
Background:Within the prosthetics profession, there is a lack of evidence to support many clinical practices. It is therefore important that clinicians systematically document and evaluate their daily practices.Objectives:To record preoperative characteristics and functional outcomes for patients with a lower limb amputation and to investigate variations between prosthetic users and non-prosthetic ...
Anass M Abbas - - 2013
The use of Toombak has been reported to play a major role in the etiology of oral cancer in Sudan. The cellular proliferative activity on the oral epithelium of 210 Toombak dippers was assessed by applying the micronuclei frequency, mean argyrophilic nucleolar organizer region (AgNOR) counts, Papanicolaou method, and 1% ...
Dadzie Samuel S Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana. - - 2013
NO MAS (NM) mosquito repellent was evaluated in two farming villages (4 km apart) in the Kassena Nankana district of northern Ghana. We determined its efficacy against local malaria vectors, degree of user acceptance, and its effect on malaria prevalence in households using insecticide-treated bed nets. The average protective efficacy ...
van Haelst Ingrid M M - - 2012
OBJECTIVE: To investigate the occurrence of intraoperative hemodynamic events when antidepressive treatment with monoamine oxidase inhibitors (MAOIs) was continued during anesthesia. METHOD: A retrospective observational cohort study was conducted among patients who were admitted for elective surgery requiring anesthesia in 8 Dutch hospitals (2004-2010). The index group included current users ...
Tsai Tzung-Jiun - - 2012
Clopidogrel is associated with a high incidence of upper gastrointestinal bleeding in high-risk patients. However, the characteristic upper gastrointestinal lesions in symptomatic clopidogrel users remain unclear. The aims of this study were to investigate the characteristics of endoscopic findings in clopidogrel users undergoing endoscopy for upper gastrointestinal symptoms and to ...
Goertz O - - 2012
OBJECTIVE: Extensive wounds of burn patients remain a challenge due to wound infection and subsequent septicemia. We wondered whether extracorporeal shock wave application (ESWA) accelerates the healing process. The aim of the study was to analyze microcirculation, angiogenesis and leukocyte endothelium interaction after burns by using ESWA with two types ...
Abbassi-Ghadi N - - 2012
AIMS: To review the results and cost of a rolling ultrasound-guided foam sclerotherapy (UGFS) treatment programme for patients with chronic superficial venous insufficiency. METHOD: A prospective study of a rolling treatment programme where patients were offered unlimited follow-up at intervals of 6-8 weeks and further (top up) UGFS when necessary, ...
Brooks Johnell O - - 2012
Objective: Multiple user groups (patients and employees at a rehabilitation facility, community-dwelling seniors, and university students) participated in a study that examined their preferences for the features and functions of three novel nightstand prototypes.Background: It is valuable to get input from different user groups in order to improve furniture usefulness ...
Matamis Dimitrios - - 2012
The goal of this study was to examine the effects of coadministration of sildenafil and inhaled nitric oxide (iNO) in patients with out-of-proportion pulmonary hypertension who underwent cardiac valve replacement surgery. Twenty consecutive cardiac surgery patients with out-of-proportion pulmonary hypertension were randomly assigned postoperatively into 2 groups: group A received ...
Halland M - - 2011
Background:  Peptic ulcer disease risk factors have changed, as has the impact of treatment on morbidity and mortality. Recent data on clinical presentation and outcome are sparse in Australia. Aim:  To determine the characteristics and outcome of patients presenting with a bleeding peptic ulcer to a tertiary referral centre. Methods:  ...
Arora Ritu - - 2011
Background:  To evaluate the efficacy of topical 1% voriconazole versus 5% natamycin in treatment of fungal corneal ulcers. Design:  A prospective, randomized pilot study in a tertiary care hospital. Participants:  Thirty patients of microbiologically proven fungal keratitis divided randomly in two groups of 15 patients each. Methods:  Two groups were ...
Kim J Y - - 2011
The aim of this study was to investigate the incidence of intraocular pressure (IOP) elevation after resident-performed cataract surgery and to determine variables, which influence postoperative day 1 (POD1) IOP. In all, 1111 consecutive cataract surgeries performed only by training residents between 1 July 2001 and 30 June 2006 were ...
Seider Michael I - - 2011
PURPOSE: To compare outcomes between resident-performed trabeculectomy and Ex-PRESS shunt implantation. METHODS: A consecutive cohort of 36 Ex-PRESS shunt implantations and 57 trabeculectomies (1 eye/patient) performed by resident surgeons in their third year of ophthalmic training at the University of California, San Francisco and at the San Francisco Veterans Administration ...
Fletcher Kathlyn E - - 2011
The ACGME-released revisions to the 2003 duty hour standards. To review the impact of the 2003 duty hour reform as it pertains to resident and patient outcomes. Medline (1989-May 2010), Embase (1989-June 2010), bibliographies, pertinent reviews, and meeting abstracts. We included studies examining the relationship between the pre- and post-2003 ...
Farahmand Shervin - - 2011
BACKGROUND: Deep vein thrombosis (DVT) is prevalent in the emergency departments. Nearly 60% of them may lead to pulmonary embolism. A complete color-flow duplex ultrasound (CFDU), performed by the radiologists, is the most common diagnostic method used to detect DVT. A limited B-mode compression technique (BMCT) can also be useful ...
Kawar Eyad - - 2011
Data on the perfomance of physician assistants in a medical intensive care unit are scarce. To compare clinical outcomes between patients admitted to a resident-run MICU and a PA-run MICU. Retrospective analysis of prospectively collected MICU data was performed for 5,346 patients admitted to an MICU from January 2004 through ...
Yap Tet - - 2011
To report on the largest series to date of ulceration of the external genitalia, related to treatment with nicorandil - a vasodilator for the prevention and long-term treatment of angina - and to review the literature on the subject, focusing on the clinical features and the pathogenesis of this rare, ...
Barker Christopher A - - 2010
Intravenous contrast media (ICM) administration is recommended as part of radiation therapy simulation in a variety of clinical scenarios but can cause adverse events. The aims of this study were to assess radiation oncology residents' knowledge about ICM and to determine if an educational intervention (EI) could improve this level ...
Elkjaer Margarita - - 2010
The natural history of ulcerative colitis requires continuous monitoring of medical treatment via frequent outpatient visits. The European health authorities' focus on e-health is increasing. Lack of easy access to inflammatory bowel disease (IBD) clinics, patients' education and understanding of the importance of early treatment at relapse is leading to ...
Au Karen - - 2010
To evaluate changes in vascular and musculoskeletal involvement in subjects in the Scleroderma Lung Study, a multicenter, double-blind, randomized, controlled trial comparing placebo treatment with oral cyclophosphamide (CYC) for 1 year in systemic sclerosis patients with interstitial lung disease. Subjects were then followed off the study agent for an additional ...
Mannon Peter J - - 2011
Ulcerative colitis is associated with increased interleukin 13 (IL-13) production by natural killer T cells. Taking advantage of the inhibitory actions of interferon β on IL-13 expression, this proof-of-concept study aimed to show that decreasing IL-13 production is associated with clinical improvement of ulcerative colitis symptoms. Open-label interventional drug trial. ...
McMahon Lillian - - 2010
Sickle cell leg ulcers are often debilitating, refractory to healing, and prone to recurrence. Healing of leg ulcers was incidentally observed during dose-ranging trials of Arginine Butyrate in beta haemoglobinopathies. Here, a controlled Phase II trial was performed in sickle cell patients who had lower extremity ulcers refractory to standard ...
Löndahl M - - 2011
The randomised, double-blind, placebo-controlled Hyperbaric Oxygen Therapy (HBOT) in Diabetic Patients with Chronic Foot Ulcers (HODFU) study showed beneficial effect of HBOT. As this treatment is expensive and time-consuming, being able to select patients for therapy would be very useful. The aim of this study was to evaluate whether circulatory ...
Marrocco Christopher J - - 2010
Conventional treatment of chronic venous disease with ulceration is layered compression dressings. Saphenous vein stripping is reserved for recurrent or nonhealing ulcers. This study examines outcomes of aggressive endovenous therapy in promoting ulcer healing and/or preventing ulcer recurrence. The role of additional perforator vein ablation also is analyzed. This retrospective ...
Janković Aleksandar - - 2010
Venous leg ulcers are an important and common health problem. The aim of this study was to determine the effects of herbal therapies alone or in combination with physical therapy in the treatment of venous ulcers, as well as their antibacterial effects. Our study included 60 patients (3 groups, 20 ...
Miyabe-Nishiwaki T - - 2010
A 24-year-old, male chimpanzee (Pan troglodytes) developed acute tetraparesis. Magnetic resonance imaging showed a diffuse T2-weighted hyperintensive lesion, indicating inflammation at the C1-2 level. All infective, autoimmune, and vascular investigations were unremarkable. The chimpanzee's condition most resembled acute transverse myelitis (ATM) in humans. The chimpanzee was in severe incapacitated neurological ...
Pang K H - - 2010
To determine healing and recurrence rates following ultrasound-guided foam sclerotherapy (UGFS) of superficial venous reflux (SVR) in patients with healed (clinical, etiologic, anatomic and pathophysiologic (CEAP) classification, C5) and open (C6) chronic venous ulceration (CVU). Between 1 March 2005 and 31 December 2009, 130 consecutive patients (132 limbs, 49 CEAP ...
Thia Kelvin T - - 2011
Endoscopic evaluation plays a pivotal role in the assessment of treatment response in ulcerative colitis (UC). This study aimed to determine the interobserver agreement (IOA) for assessment of mucosal lesions, and to determine lesions predictive of global assessment of endoscopic severity (GAES). Fifty-one UC patients had digital videorecording of their ...
Asuquo Maurice E - - 2010
OBJECTIVE: This study was to evaluate the current pattern and risk factors of Marjolin's ulcer in the authors' setting. SETTINGS AND PARTICIPANTS: Twenty-one patients with histological diagnosis of skin malignancy at the University of Calabar Teaching Hospital, Calabar, Nigeria. METHODS: Presented are patients with histologic diagnosis of Marjolin's seen in ...
Bush Ronald G - - 2010
Treatment of healing venous ulcers continues to be a challenge; currently used techniques, as adjuncts to compression therapy aid to prevent recurrence but fail to heal ulcers. A technique of terminal interruption of the reflux source (TIRS) was used. The TIRS procedure targets the terminal source of reflux. The purpose ...
Kahrom Mahdi - - 2010
Unaided and abrupt cessation of opiate use without drug substitution and step-down, referred to as "cold turkey," is a common and difficult process for substance users, and is associated with several withdrawal symptoms and complications. This report presents a preliminary series of patients treated at an urban public hospital with ...
van Asseldonk Dirk P - - 2011
Thioguanine has been used for the treatment of inflammatory bowel disease, in particular for patients who failed conventional thiopurine therapy. To date, thioguanine has been infrequently studied in ulcerative colitis. To evaluate the tolerability, safety and efficacy of thioguanine in the treatment of ulcerative colitis. A database analysis was performed ...
Aloi M - - 2010
Patients with ulcerative colitis often receive thiopurines as immunomodulators (IMs) to maintain remission and avoid corticosteroids. If unresponsive or intolerant to these agents, patients are treated with methotrexate, an antimetabolite never assessed in paediatric ulcerative colitis. To describe the experience with methotrexate in children with ulcerative colitis. Thirty-two patients (median ...
Zhou Qinghua - - 2010
To evaluate the therapeutic effect of pedical conjunctival flap transposition on refractory corneal ulcer. The data of 56 eyes of 56 patients with refractory corneal ulcer who underwent pedical conjuctival transposition in a tertiary eye unit in China from June 2005 to June 2009 were retrospectively analyzed. There were 36 ...
Tsuchiya S - - 2010
To illustrate the association between hydroxyurea and the development of ulcers. A case study is presented, in which histological changes, mean corpuscular volume (MCV) and transcutaneous oxygen tension (TcPO2) were all measured and analysed, both during hydroxyurea treatment and following it's discontinuation. Two months following the cessation of hydroxyurea therapy, ...
Chams-Davatchi Cheyda - - 2010
Genital aphthous ulcers of Behcet's disease (BD) are painful and usually resistant to local treatments. Pimecrolimus is an ascomycin macrolactam, used in inflammatory skin diseases. To discover if pimecrolimus can accelerate the healing of BD genital aphthous ulcers. Ninety patients with genital aphthous ulcers were enrolled. Only patients treated with ...
Chang Wen-Hsiung - - 2010
BACKGROUND/PURPOSE: Healing of gastric ulcers requires repair by epithelial migration and proliferation. We have found a small proportion of patients with acquired hyperplastic polyps at the healed ulcer site. The aim of this study was to identify clinical characteristics that might be associated with the development of hyper-plastic polyps at ...
Varela César - - 2010
Analyze the influence of the collateral distal vessels on ischemic ulcer healing and limb salvage after successful distal procedures, according to an angiosome model. Retrospective analysis of 76 ischemic ulcers revascularized by surgical (n = 41) and endovascular (n = 35) distal procedures. All interventions were primary procedures with single ...
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