Search Results
Results 451 - 500 of 1823
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Cellura Eleonora - - 2011
BACKGROUND: Although amyotrophic lateral sclerosis (ALS) is a relentlessly progressive disorder, early diagnosis allows a prompt start with the specific drug riluzole and an accurate palliative care planning. ALS at onset may however mimic several disorders, some of them treatable (e.g., multifocal motor neuropathy) or epidemiologically more frequent (e.g., cervical ...
Laur John J - - 2011
BACKGROUND AND OBJECTIVES: Practitioners mix faster-onset, intermediate-duration local anesthetics (LAs) with slower-onset, long-duration LAs to get fast peripheral nerve block (PNB) onset and long duration. We hypothesized that 1.5% mepivacaine (with epinephrine) (mepivacaine) or 1.5% mepivacaine (with epinephrine) mixed with 0.5% bupivacaine (mixed) would reduce PNB sensory onset by 20% ...
García-Ruiz Pedro J - - 2011
ABSTRACT: The causes and mechanism behind motor complications in Parkinson disease (PD) are still a subject of debate. Several factors including age at onset, evolution in years, and initial medication can influence the onset and severity of motor complications in PD.We studied patients with recent diagnosis of PD who were ...
Momin Suhael R - - 2011
Interruption of the excitotoxic and inflammatory pathways implicated in endolymphatic hydrops (ELH)-associated hearing loss (HL) should afford hearing protection at the neuronal level. Previous work in our laboratory in the mouse model of ELH shows that dimethyl sulfoxide (DMSO), an anti-inflammatory solvent, can slow the progression of HL before neuronal ...
Poddubnyy Denis - - 2011
OBJECTIVE.: To assess prospectively the rates and to explore predictors of radiographic spinal progression over two years in a cohort of patients with early axial spondyloarthritis (SpA). METHODS.: Two hundred and ten patients with axial SpA from the German Spondyloarthritis Inception Cohort (GESPIC) were selected for this analysis based on ...
Park Jin Hoon - - 2011
BACKGROUND: Although the transplantation of mesenchymal stem cells (MSCs) after spinal cord injury (SCI) has shown promising results in animals, less is known about the effects of autologous MSCs in human SCI. OBJECTIVE: To describe the long-term results of ten patients who underwent intramedullary direct MSCs transplantation into injured spinal ...
Zhao Xiaotao - - 2011
OBJECTIVE: To introduce the surgical strategy of extensive laminectomy (with inner 1/4 facet joint resection to expose the origin of the nerve root) and to discuss its benefit for the treatment of cervical ossification of the posterior longitudinal ligament (OPLL) with myelopathy. METHODS: From January 1998 to December 2005, 82 ...
Katsumi Keiichi - - 2011
STUDY DESIGN:: A retrospective study. OBJECTIVE:: To determine the clinical and imaging characteristics of postoperative C5 palsy after cervical open-door laminoplasty. SUMMARY OF BACKGROUND DATA:: Postoperative C5 palsy is a common complication of cervical laminoplasty, and although there are several hypotheses regarding its etiology, the pathogenesis and preventive measures remain ...
Yli Branka M - - 2011
Abstract Aim: To assess the effect of time of active pushing (TAP) on neonatal outcome. Materials and methods: The study population (n=36,432) was taken from a Swedish randomized control trial on intrapartum monitoring, a European Union fetal electrocardiogram trial, and from Mölndal Hospital. After validation of acid-base samples and TAP, ...
Lee Jae-Wook - - 2011
Various new delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2) have been introduced to improve its efficacy in osteogenesis. Of these, we have previously developed heparin-conjugated PLGA nanospheres (HCPN) as a long-term delivery system for BMP-2. In vitro studies have shown that the BMP-2 long-term delivery system enhances the ...
Kalani M Yashar S - - 2011
BACKGROUND: Pediatric spinal arteriovenous malformations (AVMs) are rare and complex lesions to treat. There are few reports of the endovascular and microsurgical treatment of these lesions in the pediatric population, and the treatment outcomes of these patients are not well described. OBJECTIVE: To study the clinical and radiographic outcomes of ...
Börjesson Mats - - 2011
Patients who continue to suffer from severe and disabling angina pectoris, despite optimum treatment in terms of conventional pharmacological therapy and/or revascularization procedures, have been termed as having refractory angina pectoris. The future group of patients with refractory angina pectoris will be different from today's patients and represent a 'moving ...
Ma Yuan Zheng - - 2012
There are few articles in the literature comparing outcomes between anterior and posterior instrumentation in the management of thoracic and lumbar spinal tuberculosis (TB). Between January 2004 and December 2009, 217 adult patients, average age 39 (range 16-67) years with thoracic and lumbar spinal TB were treated by anterior radical ...
Ruiz-Juretschke Fernando - - 2011
Spinal dural arteriovenous fistulas (SDAVF) are the most frequently occurring vascular malformations of the spinal cord but their optimal treatment remains contentious. We retrospectively analyzed 19 consecutive patients treated between 1996 and 2007. Endovascular embolization was considered the first treatment option for nine patients. Ten patients did not fulfill the ...
Liang Shan - - 2011
Amyotrophic lateral sclerosis (ALS) is a progressive, uniformly fatal, degenerative disorder of the upper motor neurons that does not currently have an effective treatment regimen. Here, we report two patients with ALS who were treated with 4 weeks of acupuncture injection point therapy using Enercel. These patients were administered 0.25-0.5 ...
Wu Jau-Ching - - 2011
ABSTRACT The optimal treatment strategy for ossification of the posterior longitudinal ligament (OPLL) depends on symptoms and is uncertain. Whether the risk of spinal cord injury (SCI) is increased in patients with cervical spinal stenosis or myelopathy caused by OPLL remains unclear. This study aimed to evaluate the risk of ...
Xiong Min - - 2011
Recent research based on various animal models has shown the neuroprotective effects of erythropoietin (EPO). However, few studies have examined such effects of EPO in the clinic. In this study we enrolled patients with spinal cord ischemia-reperfusion (I-R) injury to investigate the clinical application of EPO and methylprednisolone (MP) for ...
Bani-Hashem Nadia - - 2011
Spinal anesthesia has the advantage that profound nerve block can be produced in a large part of the body by the relatively simple injection of a small amount of local anesthetic. Intrathecal local anesthetics have limited duration. Different additives have been used to prolong spinal anesthesia. The effect of corticosteroids ...
Shukla Deepika D Department of Anesthesiology, Lala Lajpat Rai Hospital (Halett), Kanpur, Uttar Pradesh, - - 2011
No drug, used as adjuvant to spinal bupivacaine, has yet been identified that specifically inhibits nociception without its associated side-effects. This prospective randomized double-blind study was conducted to evaluate the onset and duration of sensory and motor block as well as perioperative analgesia and adverse effects of dexmedetomidine and magnesium ...
Khalili Gholamreza - - 2011
PURPOSE: The aim of this study was to evaluate the effect of additional magnesium sulfate (MgSO(4)) 100 mg to intrathecal (IT) isobaric 0.5% bupivacaine 3 ml on spinal anesthesia in patients undergoing lower extremity orthopedic surgery. METHODS: In a double-blind randomized clinical trial, 79 American Association of Anesthesiologists (ASA) I or II ...
McDonald Sarah - - 2011
Background:Minimizing hypotension associated with spinal anesthesia for cesarean delivery by administration of IV fluids and vasopressors reduces fetal and maternal morbidity. Most studies have concentrated on noninvasive systolic blood pressure (SBP) measurements to evaluate the effect of such regimens. We used a suprasternal Doppler flow technique to measure maternal cardiac ...
Loubert Christian - - 2011
Background:Difficulties in inserting an epidural catheter while performing combined spinal-epidural anesthesia for cesarean delivery may lead to undue delays between the spinal injection of the local anesthetic mixture and the adoption of the supine position with lateral tilt. We hypothesized that this delay may affect the intrathecal distribution of local ...
de Jong Lex D - - 2011
de Jong LD, Hoonhorst MH, Stuive I, Dijkstra PU. Arm motor control as predictor for hypertonia after stroke: a prospective cohort study. To analyze the development of hypertonia in the hemiparetic elbow flexors, and to explore the predictive value of arm motor control on hypertonia in a cohort of first-ever ...
Sharma B - - 2011
The problem of tissue coring exists despite the availability of smaller gauge spinal needles with special tip designs. The aim of the study was to test the hypotheses that a) subarachnoid block given as a part of a combined spinal epidural intervention by needle-through-needle technique introduces a lesser number of ...
Yamaguchi Tomofumi - - 2011
We evaluated the efficacy of a novel electromyogram (EMG)-controlled electrical stimulation system, called the integrated volitional control electrical stimulator (IVES), on the recovery of upper extremity motor functions in patients with chronic hemiparetic stroke. Ten participants in the chronic stage (more than 12 months post-stroke with partial paralysis of their ...
Hodt-Billington Caroline C Section of Physiotherapy Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway. - - 2011
To investigate the magnitude of change at different time points in measures of gait symmetry, gait velocity and self-reported function following total hip replacement. Longitudinal with test occasions pre-surgery and 3, 6 and 12 months post-surgery. Thirty-four patients with hip osteoarthritis (mean age 63 years, standard deviation 11 years). Subjects ...
Zibetti Maurizio - - 2011
Deep brain stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The benefits of bilateral subthalamic stimulation are well documented, and some studies reported outcomes with a follow-up of 5 to 6 years; nevertheless, few data are available beyond 5 years. We report a long-term prospective ...
Kijima Yasufumi - - 2012
A recent study has shown that cryptogenic stroke can occur even in patients with small or insignificant atrial septal defects (ASD). However, clinical experience in this field is still limited in Japan, also the efficacy and safety of catheter closure of such defects have not been identified. To evaluate the ...
Gundersen M D - - 2011
Background: To determine the annual incidence rate and clinical features of amyotrophic lateral sclerosis (ALS) in Møre and Romsdal County, Norway, in the 20-year period from 1988 to 2007. Methods: We recruited ALS patients retrospectively from the patient database of the two neurological departments in Møre and Romsdal County, Norway. ...
Colini Baldeschi Gianni - - 2011
Introduction:  The aim of our study is to identify the assessment of metabolic and dynamic capillaroscopy parameters that may be predictive of the outcome of spinal cord stimulation in patients affected with non-revascularisable chronic critical limb ischemia. Materials and Methods:  Forty patients, 16 female and 24 male, average age 69 ...
Onishi Eijiro - - 2011
Study Design. Retrospective review.Objective. To identify risk factors for traumatic cervical spinal cord injury (SCI) associated with ossification of the posterior longitudinal ligament (OPLL) by comparing patients with SCI and those with cervical myelopathy (CM) associated with OPLL.Summary of Background Data. Although the prevalence of OPLL among patients with cervical ...
Davis A M - - 2011
OBJECTIVE: Primary total hip (THR) and knee (TKR) replacement outcomes typically include pain and function with a single time of follow-up post-surgery. This research evaluated the trajectory of recovery and inter-relationships within and across time of physical impairments (PI) (e.g., symptoms), activity limitations (AL), and social participation restrictions (PR) in ...
Bouchoucha Sami - - 2011
Treatment of rigid and severe spinal deformities is challenging and risky. Preoperative halo-gravity traction can be used to progressively reduce the deformity before spinal fusion. The aim of this study was to evaluate the effectiveness of halo-gravity traction for the correction of severe spinal deformities. Fifteen patients were reviewed retrospectively. ...
Soberg Helene L - - 2011
: The process of returning to work (RTW) after multiple injuries is lengthy. Prospective studies with follow-up times of up to 5 years are necessary but lacking. The aim of this study was to describe the trajectory of RTW and to examine the factors that predicted RTW over 5 years ...
Saberi Hooshang - - 2011
Object Many experimental studies on spinal cord injuries (SCIs) support behavioral improvement after Schwann cell treatment. This study was conducted to evaluate safety issues 2 years after intramedullary Schwann cell transplantation in 33 consecutively selected patients with SCI. Methods Of 356 patients with SCIs who had completed at least 6 ...
Zhang Di - - 2011
To compare the technical difficulty and safety of epidural catheterization between cranial and caudal lumbar region, thirteen dogs were randomly assigned to a cranial lumbar group (group CraL, n=6) or a caudal lumbar group (group CauL, n=6) depending on different epidural sites, and one dog was used as a negative ...
Sawalha S - - 2012
No direct intra-operative measurement to determine the ideal size of the femoral component of Oxford unicompartmental knee replacement (UKR) is currently present. The aim of this study is to assess the accuracy of patients' shoe size as a predictor of femoral component size. A retrospective study was conducted to identify ...
Maslehaty Homajoun - - 2011
We demonstrate clinical features, therapy and outcome of 14 patients with symptomatic spinal cavernous malformations (CM). We retrospectively reviewed all patients who underwent microsurgical treatment of symptomatic spinal CM during the last decade in our department through an analysis of our database. We analyzed the data of 14 patients (11 ...
Park Chan Hong - - 2011
Spinal stenosis is a narrowing of the spinal canal, which causes mechanical compression of spinal nerve roots. The compression of these nerve roots can cause low back pain and/or leg pain, as well as neurogenic claudication. Lumbar epidural steroid injections have commonly been used in patients with lumbar spinal stenosis ...
Fuzier Régis - - 2011
BACKGROUND AND OBJECTIVES:: Different mechanisms have been proposed to explain spinal anesthesia failure even after LA injection into the subarachnoid space. The aim of this prospective multicenter study was to assess the incidence of spinal anesthesia failure, excluding technical problems, and then to suggest independent factors leading to failure. METHODS:: ...
Bischoff Moritz S - - 2011
In a porcine model, we investigated the impact of sudden stent graft occlusion of thoracic intercostal arteries after open lumbar segmental artery (SA) ligation. After randomization into two groups, 20 juvenile Yorkshire pigs (27.1 ± 0.6 kg) underwent open lumbar SA sacrifice (T(13)-L(5)) followed by endovascular coverage of all thoracic ...
Gupta Rajni - - 2011
Spinal anaesthesia is the most common approach which is used for lower limb surgery. Dexmedetomidine is the recent drug which acts on α2-adrenergic receptors in the dorsal horn of the spinal cord to produce analgesic effects. Efficacy and safety of intrathecal dexmedetomidine added to ropivacaine. Randomised double blind trial. Sixty ...
Korula Sara - - 2011
Ropivacaine is a long-acting amide local anesthetic, which is structurally very similar to bupivacaine but produces less motor block and less cardiac and central nervous system toxicity. It is also about 40% less potent than bupivacaine. Our double blind study was designed to compare the clinical efficacy of the equipotent ...
Gupta Rajni R Department of Anaesthesia, Chhatrapati Shahuji Maharaj Medical University, Uttar Pradesh, Lucknow, - - 2011
Various adjuvants have been used with local anesthetics in spinal anesthesia to avoid intraoperative visceral and somatic pain and to provide prolonged postoperative analgesia. Dexmedetomidine, the new highly selective α2-agonist drug, is now being used as a neuraxial adjuvant. The aim of this study was to evaluate the onset and ...
Bauman W A - - 2011
Men with spinal cord injury are at an increased risk for secondary medical conditions, including metabolic disorders, accelerated musculoskeletal atrophy, and, for some, hypogonadism, a deficiency, which may further adversely affect metabolism and body composition. A prospective, open label, controlled drug intervention trial was performed to determine whether 12 months ...
Kehrer Christiane - - 2011
Aim  Motor deterioration is a key feature in metachromatic leukodystrophy (MLD). The lack of data about its natural course impedes evaluation of therapeutic interventions. This study aimed to provide data about motor decline in MLD. Method  Fifty-nine patients (27 males, 32 females) with MLD (21 with late-infantile MLD and 38 ...
Liu Xiang - - 2011
BACKGROUND AND PURPOSE: To evaluate the time periods of Wallerian degeneration (WD) in which the diffusion parameters of ipsilateral corticalspinal tract (CST) can be used to predict the motor function outcome after brain infarction. METHODS: This retrospective study classified 48 diffusion tensor imaging patients with WD along CST into four ...
Wu Jau-Ching - - 2011
Object The study aimed to verify the safety and feasibility of applying acidic fibroblast growth factor (aFGF) with fibrin glue in combination with surgical neurolysis for nonacute spinal cord injury. Methods This open-label, prospective, uncontrolled human clinical trial recruited 60 patients with spinal cord injuries (30 cervical and 30 thoracolumbar). ...
Lyalka Vladimir F - - 2011
In quadrupeds, spinalization in the thoracic region severely impairs postural control in the hindquarters. The goal of this study was to improve postural functions in chronic spinal rabbits by regular application of different factors - intrathecal injection of 5-HT2 agonist, DOI; epidural electrical spinal cord stimulation, EES; and specific postural ...
Sathitkarnmanee Thepakorn - - 2011
Levobupivacaine is a new long-acting local anesthetic, which is the isolated S-enantiomer of racemic bupivacaine with less cardiovascular and central nervous system toxicity than bupivacaine. Reports using levobupivacaine for epidural or brachial plexus anesthesia suggested equivalent clinical efficacy to bupivacaine. However, inadequate information for spinal anesthesia was found To study ...
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