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Delgadillo Verónica - - 2011
BACKGROUND: Mucopolysaccharidosis type III (Sanfilippo syndrome) is a group of autosomal recessive disorders caused by a deficiency in one of the four enzymes involved in the lysosomal degradation of heparan sulfate. Genistein supplementation has been proposed as a potential therapy for the reduction of substrates in patients with these disorders. ...
Melkas Susanna - - 2011
BACKGROUND: Delirium is a frequent post-stroke complication that compromises effective rehabilitation and has been associated with poor outcome. We aimed to investigate whether delirium is associated with increased risk of post-stroke dementia and long-term mortality once confounding is taken into account. METHODS: The study comprised 263 consecutive acute ischemic stroke ...
Makani Harikrishna - - 2011
OBJECTIVE: Peripheral edema is considered to be a common and annoying adverse effect of calcium channel blockers (CCBs). It has been thought to occur secondary to arteriolar dilatation causing intracapillary hypertension and fluid extravasation. We aimed to evaluate the incidence and withdrawal rate of peripheral edema with CCBs. METHODS: A ...
Kim Hyoung-Il - - 2011
BACKGROUND: Vitamin B12 deficiency is a common long-term sequelae after total gastrectomy. Intramuscular injection of vitamin B12 is the only known treatment. We investigated the efficacy and safety of oral vitamin B12 replacement for gastric cancer patients with vitamin B12 deficiency after total gastrectomy. METHODS: We performed a single-arm, open-label, ...
Beer Tomasz M - - 2011
PURPOSE: Sipuleucel-T, an autologous cellular immunotherapy, was investigated in a randomized, double-blind, controlled trial to determine its biologic activity in androgen dependent prostate cancer (ADPC).EXPERIMENTAL DESIGN: Patients with prostate cancer detectable by serum prostate specific antigen (PSA) following radical prostatectomy received 3 to 4 months of androgen suppression therapy, and ...
McQuarrie Emily P - - 2011
BACKGROUND: Contemporary studies analysing the long-term outcomes of patients with idiopathic membranous nephropathy and nephrotic syndrome in the era of evidence-based antiproteinuric and immunosuppressive therapies are sparse. Controversy also persists regarding which immunosuppression (IS) regimen to use. In this retrospective cohort study, we aimed to characterize time to partial remission ...
Ito Shuichi - - 2011
Rituximab (RTX) has a significant steroid-sparing effect in children with steroid-dependent nephrotic syndrome (SDNS). However, patients are likely to relapse with the recovery of CD20+ cells. We conducted a small prospective cohort study with a historical control to evaluate the effect of RTX infusion followed by mycophenolate mofetil (MMF) as ...
Saran T - - 2011
Supraventricular arrhythmias (SVA) are common after thoracic surgery and are associated with increased morbidity and mortality. This prospective, randomized, double-blind, placebo-controlled trial examined the effects of perioperative magnesium on the development of postoperative SVA. Two hundred patients undergoing thoracotomy for lobectomy, bi-lobectomy, pneumonectomy, or oesophagectomy were recruited and randomly allocated ...
den Exter Paul L - - 2011
The routine use of modern computed tomography scanners has led to an increased detection of incidental pulmonary embolism (PE), in particular in patients with cancer. The clinical relevance of these incidental findings is unknown. In this retrospective cohort study, oncology patients in whom PE was objectively proven between 2004 and ...
Wefel Jeffrey S - - 2011
Neurocognitive decline is a frequent adverse effect of glioblastoma. Antitumor therapies that are efficacious, as measured by traditional endpoints such as objective response (OR) and progression-free survival (PFS), and have beneficial effects on neurocognitive function (NCF) are of clinical benefit to these patients. We evaluated neurocognitive changes across time in ...
Marini Carlo - - 2011
Patients with inoperable chronic thromboembolic pulmonary hypertension (Inop-CTEPH) treated with conventional therapy have a poor survival. We compare the 3-year survival between those treated with conventional therapy and those treated with conventional therapy and a combination of novel drugs. We also evaluate the clinical course. A total of 34 Inop-CTEPH ...
Celik Oner - - 2012
To identify the effect of septorhinoplasty with spreader grafts on patients' perception of voice and to measure formant frequencies that may be responsible for perceived changes in voice quality. A total of 20 patients who underwent septorhinoplasty and had spreader grafts placed during the operations were included. All subjects were ...
Gu Jun - - 2011
Aims Pioglitazone, one of the peroxisome proliferator-activated receptor-gamma activators, possesses anti-inflammatory and antioxidant properties. In the present study, we sought to identify the impact of pioglitazone on the outcome of catheter ablation for paroxysmal atrial fibrillation (PAF). Methods and results We conducted a prospective observational cohort study of 150 consecutive ...
El-Hamamsy Ismail - - 2011
BACKGROUND: Total root replacement with biologic valves and reimplantation of the coronaries gives good early and midterm results. There is continuing concern, however, regarding the risks and long-term results for reoperation after total replacement of the aortic root with reimplantation of the coronaries. METHODS: Between June 1981 and July 2010, ...
Kumar Atul - - 2011
AIMS AND METHODS: Coaptive thermo coagulation (CTC) for the treatment of stigmata of recent hemorrhage (SRH) in the colon is risky. We evaluated the safety and effectiveness of endoclips in 13 patients with acute lower gastrointestinal bleeding (GIB). Thirty-day re-bleeding and complication rates were comparable to a historical cohort of ...
Kunikowska Jolanta - - 2011
Peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues is a treatment option for patients with disseminated neuroendocrine tumours (NET). A combination treatment using the high-energy 90Y beta emitter for larger lesions and the lower energy 177Lu for smaller lesions has been postulated in the literature.The aim of the study ...
Lim Fat Mary Jane - - 2011
The purpose of this study was to assess YouTube videos for their efficacy as a patient resource for infantile spasms. Videos were searched using the terms infantile spasm, spasm, epileptic spasm, and West syndrome. The top 25 videos under each term were selected according to set criteria. Technical quality, diagnosis ...
Døssing Helle - - 2011
Aim: To evaluate the long-term efficacy of interstitial laser photocoagulation (ILP) in solitary benign thyroid nodules. Design and methods: Seventy-eight euthyroid outpatients (45 participating in randomized trials) with a benign solitary solid and scintigraphically cold thyroid nodule causing local discomfort were assigned to ILP. ILP (using one laser fibre) was ...
Taşçı Ali Ihsan - - 2011
OBJECTIVES: To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS: Two experienced surgeons performed 120-W HPS laser PVP. The baseline characteristics, perioperative data, complications, and ...
Murray Gisela - - 2011
Object The purpose of this study was to describe a 10-year experience in the use of radiosurgery (RS) for patients with arteriovenous malformations (AVMs) in Puerto Rico. Methods This retrospective analysis was performed for all patients with AVMs treated with RS by the senior author (R.H.B.) in Puerto Rico. Between ...
Gallacher P D - - 2011
Meniscal tears are commonly associated with traumatic rupture of the anterior cruciate ligament (ACL). At our centre, if a patient presents with locked knee in conjunction with an ACL injury we perform an initial arthroscopy to remove the cause of locking and schedule ACL reconstruction once a full range of ...
Parashar Bhupesh - - 2011
PURPOSE: The aim of this study was to evaluate and compare sublobar resection plus intraoperative seed implant (IOS) versus stereotactic body radiation therapy (SBRT) in patients with single malignant lung nodules in patients 70 years of age or older. MATERIALS AND METHODS: A retrospective chart review was performed and 47 ...
Kim Young-Hoo - - 2011
We retrospectively reviewed 474 patients (492 hips) with a contemporary cemented total hip arthroplasty (THA) (mean age, 38.9 years) and 504 patients (532 hips) with a cementless THA (mean age, 39.3 years). Patients were evaluated clinically and radiographically. The mean follow-up was similar (14.5 vs 14.8 years) in both groups. ...
Danda Anil Kumar - - 2011
To conduct a systematic review of published clinical trials on the effectiveness of extended postoperative antibiotics in orthognathic surgery. Electronic databases were searched for randomized clinical trials. Data from relevant articles were extracted and assessed. The primary outcome variable was surgical site infection. Extracted data were analyzed using a meta-analytical ...
Gedikli Orhan - - 2011
OBJECTIVE:: To evaluate the safety and efficacy of octyl-2-cyanoacrylate for type I tympanoplasty. METHODS:: This study involved 23 patients (14 females and 9 males) with chronic otitis media who underwent type I tympanoplasty. During surgery, the temporal fascia is placed underlying the eardrum remnant, and octyl-2-cyanoacrylate was dropped over the ...
Adragao Teresa - - 2011
BACKGROUND: The ankle-brachial index (ABI) is a noninvasive method to evaluate peripheral artery disease (PAD). ABI <0.9 diagnoses PAD; ABI >1.3 is a false negative caused by noncompressible arteries. The aim of this study is to evaluate the association between ABI with vascular calcifications (VC) and with mortality, in haemodialysis ...
Altman Robert K - - 2011
A substantial proportion of patients who meet the current guidelines for cardiac resynchronization therapy (CRT) fail to respond to this pacing modality. Although appropriate patient selection and left ventricular (LV) lead location have been ascribed as determinants of CRT response, the interaction among contractile reserve, dynamics of dyssynchrony, and lead ...
Fruth Kai - - 2011
OBJECTIVES/HYPOTHESIS: Keloids are often refractive to treatment, and recurrences occur quite frequently. Radiofrequency tissue volume reduction (RFTVR) is a surgical technology that induces extensive fibrosis at the target tissues. METHODS: We applied RFTVR in 14 patients (19 auricles, 5 patients treated bilaterally; 9 female, 5 male; range, 10-66 years) with ...
Palumbo Brian T - - 2011
We evaluated the effectiveness of a novel bicompartmental knee arthroplasty prosthesis for the treatment of degenerative disease affecting the medial and patellofemoral compartments. The study included 36 knees in 32 patients with a mean follow-up of 21 months. The mean Knee Society functional survey and Western Ontario McMaster Osteoarthritic Index ...
Romme Jacobus J C M - - 2011
PURPOSE: Vasovagal syncope (VVS), the most common cause of transient loss of consciousness (T-LOC), is often accompanied by higher levels of psychological distress. We investigated to what extent psychological complaints interact with the effects of non-pharmacological treatment in patients with frequently recurring VVS. METHODS: Patients with ≥3 episodes of VVS ...
Denes Zoltan - - 2011
The objective of this study was to determine the incidence of posttraumatic hydrocephalus (PTH) among patients in our rehabilitation unit for traumatic brain injury. Furthermore, we aimed to assess the effect of shunt implantation and to identify the postoperative complication rate. This is a retrospective cohort study, in which between ...
Chakravarthi P Srinivas - - 2011
PURPOSE:: The purpose of the study was to evaluate the effectiveness of microvascular decompression treatment prospectively in 40 patients with trigeminal neuralgia who were resistant to medical treatments and underwent microvascular decompression surgery (MVDS) between the years 2008 and 2010. METHODS:: The patients' data were collected as per norms suggested ...
Steele Garen D - - 2011
The ASR (articular surface replacement) XL (DePuy, Warsaw, Ind) metal-on-metal hip arthroplasty offers the advantage of stability and increased motion. However, an alarming number of early failures prompted the evaluation of patients treated with this system. A prospective study of patients who underwent arthroplasty with the ASR XL system was ...
Elkoushy Mohamed A - - 2011
OBJECTIVES: To calculate the efficiency quotient (EQ) of the latest mobile Storz Modulith SLX-F2 lithotripter and to identify the factors determining the stone-free rate. METHODS: A retrospective review of a prospectively collected database of the first consecutive 533 patients undergoing shock wave lithotripsy (SWL) from June 2009 to February 2010 ...
Laiyemo Adeyinka O - - 2011
Colonoscopy may be less efficacious in reducing colorectal cancer mortality in the proximal compared with the distal colon. A greater likelihood for missed and recurrent adenomas in the proximal colon may contribute to this phenomenon. To examine whether a proximal adenoma is associated with the risk and location of missed ...
Cirodde Audrey - - 2011
Cultured epithelial autografts (CEAs) have long been used to tackle limited donor site availability and difficulty of permanent skin coverage in massive burns, but this approach still has limited documentation. METHODS: In this retrospective, single-center study, medical records of patients treated with CEAs in our burn center from 1991 until ...
Uprichard J - - 2011
Summary.  Total knee replacement (TKR) is a well recognized treatment for haemophilic arthropathy. Successful haemostasis can be achieved by bolus doses or continuous infusion (CI) using either recombinant (r) or plasma-derived (pd) factor IX (FIX). We retrospectively analysed our experience of factor replacement to cover TKR in haemophilia B patients ...
Hacquard Marie - - 2011
Objectives: The study aimed to describe French off-label use of rFVIIa for intractable bleeding in major cardiovascular surgery. Methods: Retrospective observational analysis of data from 2005 to October 2007 (no formal guidelines were available) was employed. The collect request form was elaborated by a multidisciplinary committee. Results: Data on 109 ...
Tolley Neil - - 2011
Objective. Targeted parathyroidectomy is the gold standard for localized parathyroid disease. A robotic-assisted approach has not been investigated. The aim was to assess the feasibility of a robotic technique that avoids a neck scar. Study Design. Feasibility study. Setting. Tertiary referral center. Subjects and Methods. Eleven patients with primary hyperparathyroidism ...
Rubin Lewis J - - 2011
ABSTRACT BACKGROUND: The long-term safety and tolerability of sildenafil treatment for pulmonary arterial hypertension (PAH) were assessed. METHODS: 259 of 277 randomized and treated patients completed a 12-week, double-blind, placebo-controlled trial (SUPER-1) of oral sildenafil in treatment-naïve patients with PAH (96% functional class II/III) and entered an open-label uncontrolled extension ...
Kement M - - 2011
Aim: This study aims to evaluate the risk factors for incontinence after lateral internal sphincterotomy (LIS) and assess quality of life in different levels of incontinence. Methods: All consecutive patients (n = 253) with chronic anal fissure who underwent LIS between 2003 and 2006 were retrospectively reviewed. All patients were ...
Levy Elad I - - 2011
BACKGROUND:: Although early data demonstrate encouraging angiographic results following intracranial stent deployment for acute ischemic stroke, longer-term follow-up is necessary to evaluate clinical outcomes, as well as durability of angiographic results. OBJECTIVE:: We report 6-month clinical and radiologic follow-up data of the 20 patients prospectively enrolled in the Stent-Assisted Recanalization ...
Dongmei Han - - 2011
Abstract Background aims. The aims of this study were to observe the safety and effectiveness of umbilical cord mesenchymal stromal cells (UC-MSC) in the treatment of spinocerebellar ataxia (SCA) and multiple system atrophy-cerebellar type (MSA-C). Methods. From October 2009 to September 2010, 14 cases of SCA and 10 cases of ...
Nayak Arun - - 2011
This study evaluates the early and mid-term outcomes, predictors of mortality and morbidity and quality of life of patients operated for infective endocarditis. Data on 108 patients undergoing 113 surgical procedures during October 1998 to January 2010 was prospectively collected. NYHA Class was >III in 49 (43.4%) cases. Thirty-seven (33%) ...
John Anitha S - - 2011
Octreotide has had limited use for the treatment of protein-losing enteropathy following the Fontan operation. We describe three cases where subcutaneous octreotide was successfully used to treat refractory protein-losing enteropathy following the Fontan operation. Patients received octreotide therapy for a period of 14-28 months. Octreotide was discontinued in one patient ...
Prakash Sanjay - - 2011
Post-infectious disease syndrome includes both neurological and non-neurological disorders. However, headache as an isolated or a presenting complaint of post-infectious illness has not been well acknowledged in the literature. In this retrospective observation, patients having daily headache of more than 1 week and <4 weeks duration were included. We divided this group ...
Stoecklein Holbrook H - - 2011
PURPOSE: To evaluate the outcomes (range of motion, function, and pain relief) of the volar approach to proximal interphalangeal (PIP) joint surface replacement arthroplasty (SRA) in active, high-demand patients. METHODS: A single surgeon performed PIP SRA in 6 joints using a volar approach. Patients with posttraumatic arthritis or osteoarthritis of ...
Yamauchi Kensuke - - 2011
PURPOSE: The aim of the present study was to evaluate the potential morphologic risk factors for postoperative neurosensory disturbance (NSD) after bilateral sagittal split osteotomy. PATIENTS AND METHODS: The study subjects were 30 skeletal Class III patients (9 males and 21 females), with a mean age of 22.0 years (range, ...
Alvarez-Díaz Pedro - - 2011
PURPOSE: The purpose of this study was to report the functional outcomes of young active soccer players with lumbar spondylolysis undergoing conservative treatment. METHODS: Between 2002 and 2004, all soccer players diagnosed with spondylolysis with a minimum 2-year follow-up were retrospectively reviewed. All patients were treated nonoperatively with cessation of ...
Cesaro Simone - - 2011
BACKGROUND: Limited data are available on the use of pegfilgrastim in pediatric patients as a mobilizing agent in association with chemotherapy. STUDY DESIGN AND METHODS: This was a prospective, multicenter, Phase II study to evaluate the safety and efficacy of a single dose of 100 µg/kg pegfilgrastim in mobilizing peripheral blood ...
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