Search Results
Results 351 - 400 of 1010
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Jung Yong Wook - - 2009
To evaluate the acute toxicity of rofecoxib during concurrent use with cisplatin-based chemoradiotherapy (CCRT) in patients with cervical cancer. We evaluated 67 FIGO stage IB2-IVA cervical cancer patients treated with CCRT between June 2002 and July 2004. The study group included patients who received rofecoxib (N=30) and the control group ...
de Abreu Marilda Aparecida Milanez Morgado - - 2009
OBJECTIVE: The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. STUDY DESIGN: In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 ...
Wattchow D A - - 2009
BACKGROUND: Ileus occurs after abdominal surgery and may be severe. Inhibition of prostaglandin release reduces post-operative ileus in a rat model. AIM: To determine whether prostaglandin inhibition by cyclooxygenase inhibitors, celecoxib or diclofenac, could enhance gastrointestinal recovery and reduce post-operative ileus in humans. METHODS: Two hundred and ten patients undergoing ...
Ong-Tone Lindsay - - 2009
PURPOSE: To determine whether adrenaline in the irrigating solution is necessary when diclofenac eyedrops are used before cataract surgery. SETTING: Pasqua Hospital, Regina, Saskatchewan, Canada. METHODS: In this prospective randomized masked study, all patients used diclofenac eyedrops 2 days preoperatively. The pupils were dilated with a wick soaked in a ...
Soni Paresh - - 2009
OBJECTIVE: To assess the hepatic safety and tolerability of celecoxib versus placebo and three commonly prescribed nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). RESEARCH DESIGN AND METHODS: This was a retrospective, pooled analysis of a 41-study dataset involving patients with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, chronic low back pain, and Alzheimer's disease. ...
Korinenko Yuliya - - 2009
BACKGROUND: Coronary artery bypass graft and cardiac valve surgeries are frequently performed in medical facilities in the United States, and postoperative nausea (PON) is a prevalent problem in this patient population. The purpose of this study was to evaluate the efficacy of a single preoperative acupuncture treatment in the prevention ...
Nelson Christopher - - 2009
Objective: To evaluate the long-term effects of treatment with diclofenac sodium 3% in 2.5% hyaluronic acid gel on clinically diagnosed actinic keratosis lesions in well-defined skin areas. Design: A one-year extension of a Phase 4, single-arm, multicenter, open-label study was conducted. Patients in the original study received diclofenac sodium 3% ...
Bozkurt Nuray - - 2009
Objective. To determine the advantages and disadvantages of the use of diclofenac sodium instead of meperidine for postcesarean section pain control. Methods. A total of 130 patients who had undergone cesarean section at the Department of Obstetrics and Gynecology of Gazi University Hospital were prospectively randomised to receive one of ...
Surakarn Jakkrid - - 2009
OBJECTIVE: To evaluate the effectiveness of intramuscular diclofenac in postoperative cesarean section pain control. STUDY DESIGN: A randomized controlled trial. SETTING: Department of Obstetrics and Gynecology, King Chulalongkorn Memorial Hospital. SUBJECTS: Eighty patients scheduled for elective cesarean section between October 2007 and April 2008. MATERIAL AND METHOD: All patients had ...
Cooper Coreen S - - 2009
One of the challenges facing veterinarians and investigators who use rabbits (Oryctolagus cuniculus) as a surgical model in biomedical research is choosing an appropriate and efficacious postoperative analgesic without systemic complications and side effects. The objective of this study was to evaluate the gastrointestinal side effects associated with the postoperative ...
Duarte Leonardo Teixeira Domingues LT Departamento de Anestesiologia Rede SARAH de Hospitais de Reabilitação SMHS 501, Conjunto A, Asa Sul70330-150 Brasília DF. - - 2009
Posterior lumbar plexus block promotes effective postoperative analgesia in total knee arthroplasty. Ropivacaine and bupivacaine do not show differences in analgesic efficacy when used in different peripheral nerve blocks. The objective of this study was to compare the efficacy of postoperative analgesia resulting from the administration of a single dose ...
Yener Murat - - 2009
OBJECTIVE: To evaluate the efficacy of liquid alginate suspension in alleviating post-tonsillectomy morbidity in adult patients. METHODS: A prospective, double-blind, randomized, placebo-controlled study comparing the effect of liquid alginate suspension with placebo was performed on 40 patients who underwent tonsillectomy at Derince State Hospital, Kocaeli, Turkey. The patients were randomly ...
Schurr M J - - 2009
OBJECTIVE: The standard opioid treatment for postoperative pain can be associated with nausea, vomiting, and constipation. In addition, opioids often provide insufficient pain relief. The purpose of this study was to compare postoperative pain and functional outcomes in patients undergoing inguinal herniorrhaphy who receive a COX-2 selective nonsteroidal anti-inflammatory drug ...
Li W - - 2009
This study investigated the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on peri-operative blood loss during elective total hip replacement. Patients were randomized to receive enteric-coated diclofenac 50 mg (n = 18), rofecoxib 12.5 mg (n = 17) or placebo (n = 16) administered orally three times daily for 2 weeks ...
Rahimi Mojgan - - 2009
BACKGROUND: Postoperative sore throat is a common problem. The efficacy of topical application of non-steroidal anti-inflammatory drugs in alleviating postoperative sore throat has not been established. Our aim was to evaluate the analgesic effects of diclofenac epolamine patch on postoperative sore throat. METHODS: The study was conducted in a prospective, ...
Becker Matthew C - - 2009
BACKGROUND: Pain management in patients with osteoarthritis or rheumatoid arthritis often requires long-term use of nonsteroidal antiinflammatory drugs (NSAIDs). However, the relative cardiovascular safety of these therapies remains uncertain. METHODS: The Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION) trial will evaluate the cardiovascular safety of ...
Talvik Inga - - 2009
This is a follow-up report of a girl, 5 years 4 months old, with classic symptoms of chronic paroxysmal hemicrania from the age of 2 years 3 months who had a complete response to indomethacin therapy. The patient suffered from frequent episodes of severe unilateral headaches for 1 year and ...
Göröcs T S - - 2009
AIMS: Paracetamol (acetaminophen) is one of the most widely used drugs for analgesia. We aimed to investigate the use of a ready-to-use intravenous (i.v.) paracetamol 1 g solution (Perfalgan) as monotherapy or as adjunct therapy in patients undergoing elective ambulatory surgery. METHODS: Open, non-controlled, observational study in six centres. Anaesthesiologists ...
Marks S - - 2009
BACKGROUND: Disseminated superficial actinic porokeratosis (DSAP) is a chronic cutaneous disorder of keratinization for which there is no known cure. Current therapies are often ineffective, painful, or unappealing. OBJECTIVE: To investigate the efficacy and safety of diclofenac sodium 3% gel for the treatment of DSAP. METHODS: Seventeen adult patients with ...
Ren Xiao-ming - - 2008
OBJECTIVE: To search for an effective therapy for treating motor disorder due to Parkinson's disease (PD). METHODS: Fifty cases in a treatment group were treated by acupuncture combined with madopar, and 30 cases in a control group treated by madopar only. RESULTS: A total effective rate of 92% was achieved ...
Penza Paola - - 2008
Buprenorphine is a potent opioid available as a transdermal delivery system (TDS) formulation. This open-label study investigated its safety, tolerability, and efficacy in 30 patients with chronic painful neuropathy. Subjects with visual analogue scale (VAS) score > or = 5 under stable analgesic treatment were entered. The starting dosage of ...
Koseoglu Banu Gurkan - - 2008
PURPOSE: Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors. MATERIALS AND METHODS: In this study, the genotoxic effects of various ...
Jovic R - - 2008
PURPOSE: Recently, nonsteroidal analgoantipyretics are recommended in the management of postoperative pain, with great attention to their safety. We conducted a randomized, single blind study to compare the analgesic efficacy and safety of ketoprofen and dipyrone (metamizole) after major head and neck surgery. PATIENTS AND METHODS: 60 patients received postoperatively ...
Mirshahi Ahmad - - 2008
PURPOSE: A prospective, randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation. METHODS: Fifty consecutive patients undergoing vitrectomy were randomly assigned to diclofenac (n = 24) or control (n = 26) groups. All patients received ...
Cesarone M R - - 2008
Patients (with venous or arterial disease) are particularly affected by even minor sprains as edema, swelling are more disabling and cause a more severe clinical picture. In such vulnerable population, it is imperative to rehabilitate the patient in shortest possible time to regain the functionality of the injured joint and ...
Pisco João M - - 2008
PURPOSE: To evaluate whether pelvic pain following uterine artery embolization (UAE) can be decreased by using ketoprofen mixed with polyvinyl alcohol (PVA). MATERIALS AND METHODS: A randomized prospective study was performed in 80 patients (age range, 25-52 years; mean age, 41 years) undergoing UAE with PVA between March and August ...
Laine Loren - - 2008
BACKGROUND & AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause lower gastrointestinal (GI) clinical events such as bleeding. Cyclo-oxygenase (COX)-2 selective inhibitors decrease upper GI events, but no prospective trial has prespecified assessment of lower GI clinical events. METHODS: Patients >or=50 years old with osteoarthritis or rheumatoid arthritis were randomly assigned to ...
McKean Simon A - - 2008
To assess the effect of postoperative diclofenac on the posttonsillectomy hemorrhage rate in adults. Retrospective chart review with Caldicott Guardian approval of patients before and after a change in the postoperative drug regimen. One hundred ninety-three adults between 16 and 56 years, American Society of Anesthesiologists Grade I, listed for ...
Cisár Peter - - 2008
OBJECTIVE: The safe and efficacious use of Pycnogenol (French maritime pine bark extract) in other inflammatory diseases prompted this study of its antiinflammatory effects in patients with osteoarthritis (OA). The aim of the study was to evaluate whether Pycnogenol reduces the symptoms of OA in a double-blind, placebo-controlled, randomly allocated ...
Nadstawek J - - 2008
Opioid-induced constipation can have a major negative impact on patients' quality of life. This randomised clinical trial evaluated patient assessment of the efficacy and tolerability of oral prolonged-release (PR) oxycodone when co-administered with oral naloxone PR. Two hundred and two patients with chronic cancer- or non-cancer-related pain undergoing stable oxycodone ...
Berlin Joshua M - - 2008
BACKGROUND: Actinic keratoses are increasingly common skin lesions that are evaluated and treated by dermatologists on a daily basis. It is estimated that more than 90% of actinic keratoses in the US are treated by destructive therapies, such as cryosurgery. The purpose of this study was to evaluate the efficacy ...
Mastrolonardo M - - 2009
This paper reviews retrospectively the results obtained in a case series of multiple refractory actinic keratoses (AKs), treated sequentially with topical diclofenac 3% gel followed by cryotherapy. In total, 29 patients were reviewed; all had >or= 5 lesions (mean 8.2; range 5-12) and a long-term history of recurrence after repeated ...
Moffet Howard H - - 2008
OBJECTIVE: This study sought a fair sample of published acupuncture clinical trials to assess whether they provided scientific rationales for their interventions, clearly differentiated their exposures or observed differences in outcomes. STUDY DESIGN AND SETTING: A systematic review of all controlled, clinical trials of acupuncture published in English in 2006 ...
Janssens Hein J E M - - 2008
BACKGROUND: Non-steroidal anti-inflammatory drugs and colchicine used to treat gout arthritis have gastrointestinal, renal, and cardiovascular adverse effects. Systemic corticosteroids might be a beneficial alternative. We investigated equivalence of naproxen and prednisolone in primary care. METHODS: We did a randomised clinical trial to test equivalence of prednisolone and naproxen for ...
Snir Nimrod - - 2008
PURPOSE: We assessed the efficacy of papaverine hydrochloride, a commonly used smooth muscle relaxant, for the treatment of renal colic as a single agent and in combination with sodium diclofenac. MATERIALS AND METHODS: A prospective, single-blind clinical study was performed at 2 centers. A total of 86 patients with acute ...
Sun Tiffany - - 2008
BACKGROUND: Controversy continues to surround the use of cyclooxygenase (COX)-2 inhibitors in the perioperative period. We designed this randomized, double-blind, placebo-controlled study to examine the hypothesis that administration of celecoxib preoperatively or postoperatively and for 3 days after major plastic surgery would improve pain control and clinically important patient outcomes. ...
Guo Aisong - - 2008
OBJECTIVE: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. METHODS: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. RESULTS: ...
Zhao Yaping - - 2008
OBJECTIVE: To compare the therapeutic effect of acupuncture for gastrointestinal neurosis with that of oral remedy. METHODS: Eighty cases were randomly divided into the following 2 groups. In the treatment group, acupuncture was given for one month at the main points of Zhongwan (CV 12), Zusanli (ST 36), Taichong (LR ...
Anwari Jamil S - - 2008
OBJECTIVE: To compare the opioid sparing effect of meloxicam, diclofenac, and placebo after abdominal hysterectomy. METHODS: This study was conducted at the Riyadh Military Hospital, Riyadh, Kingdom of Saudi Arabia from February 2004 to November 2006. Women of American Society of Anesthesiologist's classification I or II of ages 25-60 years ...
Starkoff, Brooke
The Swisswing® Biomechanical Stimulation Device has been previously used to treat muscle soreness. It is a form of vibration therapy that is beneficial in increasing circulation to treated muscles. Purpose: To determine the effectiveness of the Swisswing® Biomechanical Stimulation device for decreasing biochemical markers of muscle damage and inflammation and ...
Smirnov Grigori - - 2008
OBJECTIVE: To assess the efficacy of etoricoxib in pain treatment during thyroid surgery. DESIGN: Double-blind, placebo-controlled, randomized trial. SETTING: A secondary-level central hospital in Finland. PATIENTS: Sixty-nine consecutive patients (59 women) aged 18 to 70 years who underwent thyroid surgery. INTERVENTIONS: Patients were randomized to receive etoricoxib 120 mg (n ...
Shemer Avner - - 2008
OBJECTIVE: The purpose of this study was to evaluate the efficacy and tolerability of a mucoadhesive patch compared with a pain-relieving oral solution for the treatment of aphthous stomatitis. METHODS: Patients with active aphthous stomatitis were randomly treated either once a day with a mucoadhesive patch containing citrus oil and ...
Asano Sayaka - - 2008
PURPOSE: To compare the effectiveness of a topical nonsteroidal drug (diclofenac 0.1%) and a topical steroidal drug (betamethasone 0.1%) in preventing cystoid macular edema (CME) and blood-aqueous barrier (BAB) disruption after small-incision cataract surgery and foldable intraocular lens (IOL) implantation. SETTINGS: Shohzankai Medical Foundation Miyake Eye Hospital, Tokyo, Japan. METHODS: ...
Wang Xiao-Yun - - 2008
A randomized single-blind trial was conducted to evaluate the efficacy of short-term abdominal acupuncture as a novel treatment for insomnia in Chinese women. Forty-four patients between the ages of 22 and 56 were randomly assigned to an acupuncture (n = 23) and a medication group (n = 21). The acupuncture ...
Karow Jens-Hagen - - 2008
OBJECTIVE: This study was undertaken to answer the question: "Is Arnica D4 as efficacious as diclofenac in relation to symptoms and wound healing after foot surgery?" METHODS: In this randomized double-blinded, parallel-group study (GCP-standard), the efficacy of Arnica D4 10 pillules (taken orally, 3 times per day) and diclofenac sodium, ...
Weiss Hans-Rudolf - - 2008
Today, acupuncture therapy is commonly used for pain control throughout the world, although the putative mechanisms are still unclear. A Pub Med search for the key words "Acupuncture" and "Scoliosis" reveals 3 papers only, not containing any results of studies designed for the treatment of scoliosis with the help of ...
Kose Osman - - 2008
BACKGROUND: Topical diclofenac and imiquimod have been reported to be effective in the treatment of actinic keratosis, but a study to compare these two drugs has not been reported yet. OBJECTIVE: To compare the efficacy and safety of topical 3% diclofenac gel plus hyaluronic acid and 5% imiquimod cream in ...
Quercia O - - 2008
Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are a frequently reported problem due to the fact that these molecules are often used for control of pain and inflammation. Although the use of selective inhibitors of cyclooxygenase (COX) 2 helps to prevent some of these adverse reactions, they can have cardiac ...
Nishiike Suetaka - - 2007
STUDY OBJECTIVE: To investigate the analgesic efficacy of preoperative flurbiprofen on postoperative pain after tonsillectomy. DESIGN: Prospective, randomized, nonblinded, non-placebo-controlled study. SETTING: Municipal hospital. PATIENTS: Twenty-five ASA physical status I patients older than 20 years of age, who were scheduled for tonsillectomy. INTERVENTIONS: Patients were randomly allocated to two groups ...
Karabuda Zihni Cuneyt - - 2007
BACKGROUND: The analgesic and anti-inflammatory efficacy of tenoxicam and meloxicam were evaluated in this double-masked, randomized, prospective study by analyzing pain scores and the need for rescue-analgesic agents following dental implant surgery. METHODS: One hundred patients, in whom 241 dental implants were placed, were divided into two groups. For 4 ...
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