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Lubelski Daniel - - 2014
Anterior cervical discectomy and fusion (ACDF) and posterior cervical foraminotomy (PCF) are both used to surgically treat patients with cervical radiculopathy, and have been shown to have similar outcomes. Nonetheless, ACDF has become increasingly more commonplace compared with PCF, in part because of a pervasive belief that PCF has a ...
Losina Elena E Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Department of Biostatistics, Boston University School of Public Health, Boston, - - 2014
Objective: The impact of increasing utilization of total knee arthroplasty (TKA) on lifetime costs in persons with knee OA is under-studied. Methods: We used the Osteoarthritis Policy Model to estimate total lifetime costs and TKA utilization under a range of TKA eligibility criteria among US persons with symptomatic knee OA. ...
McDermott Mary M MM Northwestern University's Feinberg School of Medicine, Chicago, IL, USA - - 2014
Associations of collateral vessels and lower extremity plaque with functional decline are unknown. Among people with peripheral artery disease (PAD), we determined whether greater superficial femoral artery (SFA) plaque burden combined with fewer lower extremity collateral vessels was associated with faster functional decline, compared to less plaque and/or more numerous ...
Schmieder Roland E RE Department of Nephrology and Hypertension, University Hospital of the University Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany, - - 2014
Urinary albumin excretion is a strong predictor of cardiovascular disease. It is uncertain whether improvement from microalbuminuria or deterioration from normoalbuminuria over time in patients with differing changes in glucose and BP change their cardiovascular risk. Data on mortality, cardiovascular and renal outcomes were analysed in 22,984 patients from two ...
Jain Saransh - - 2014
Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortality is unclear. This prospective observational study was designed to study the prognostic value of procalcitonin in prediction of 28 day mortality in patients of sepsis. Fifty-four consecutive patients of sepsis, severe sepsis and septic shock defined ...
Yoshihara Hiroyuki H Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003. E-mail address: - - 2014
Although life expectancy continues to increase worldwide and advances occur in surgical techniques and medical treatment, the chronological age limit for patients to undergo elective major orthopaedic procedures remains a controversial subject. The purpose of this study was to examine the trends in the incidence and in-hospital outcomes of elective ...
Olafson Kendiss K Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, - - 2014
To compare methods of characterizing intensive care unit (ICU) bed use and estimate the number of beds needed. Three geographic regions in the Canadian province of Manitoba. Retrospective analysis of population-based data from April 1, 2000, to March 31, 2007. We compared three methods to estimate ICU bed requirements. Method ...
Liddle Alexander D AD Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, - - 2014
Total knee replacement (TKR) or unicompartmental knee replacement (UKR) are options for end-stage osteoarthritis. However, comparisons between the two procedures are confounded by differences in baseline characteristics of patients undergoing either procedure and by insufficient reporting of endpoints other than revision. We aimed to compare adverse outcomes for each procedure ...
Saxena Akshat A Department of Cardiothoracic Surgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, - - 2014
To evaluate the impact of preoperative atrial fibrillation (pre-op AF) on early and late mortality after isolated coronary artery bypass graft (CABG) surgery. Data obtained prospectively between June 2001 and December 2009 by the Australasian Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database Program were retrospectively analyzed. Patients ...
Liew A A Department of Medicine, National University of Ireland Galway (NUIG), Galway, - - 2014
In patients with nonvalvular atrial fibrillation (AF), direct oral anticoagulants (DOACs) are at least non-inferior to warfarin for the prevention of stroke and systemic embolism. The main objective of this study was to obtain reliable and precise estimates for all-cause mortality, vascular mortality and bleeding mortality in patients with AF ...
Wingfield Tom T Innovación Por la Salud Y Desarrollo (IPSYD), Asociación Benéfica PRISMA, Lima, Perú; Innovation For Health And Development (IFHAD), London, United Kingdom; Infectious Diseases & Immunity, Imperial College London, and Wellcome Trust Imperial College Centre for Global Health Research, London, United Kingdom; The Monsall Infectious Diseases Unit, North Manchester General Hospital, Manchester, United - - 2014
Even when tuberculosis (TB) treatment is free, hidden costs incurred by patients and their households (TB-affected households) may worsen poverty and health. Extreme TB-associated costs have been termed "catastrophic" but are poorly defined. We studied TB-affected households' hidden costs and their association with adverse TB outcome to create a clinically ...
Sannino Anna A Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, - - 2014
There is conflicting evidence regarding the safety and efficacy of transcatheter aortic valve implantation (TAVI) procedures in patients with severe aortic stenosis and low left ventricular ejection fraction (EF). The primary aim of this study was to determine the impact of TAVI on short- and long-term mortality in patients with ...
Mases A A Department of Anaesthesiology, Parc de Salut Mar, Pg. Marítim 25-29, 08003 Barcelona, Spain - - 2014
Chronic kidney disease is an independent predictor of perioperative cardiovascular morbidity and mortality. We analysed the preoperative estimated glomerular filtration rate (eGFR) as a risk factor for perioperative major adverse cardiovascular and cerebrovascular events (MACCE) in non-cardiac surgery. In a post hoc analysis of the ANESCARDIOCAT database, patients were classified ...
Labaf Ashkan A Department of Clinical Sciences, Malmö, Lund University, Sweden; Department of Cardiology, Skåne University Hospital, Malmö, Sweden. Electronic address: - - 2014
Low incidences of thromboembolism (TE) and bleeding in patients with mechanical heart valves (MHV) have previously been reported. This study assesses the incidence of and clinical risk factors predicting TE, major bleeding and mortality in a clinical setting. All 546 patients undergoing anticoagulation treatment due to MHV replacement at hospitals ...
Thourani Vinod H VH Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia. Electronic address: - - 2014
Concomitant aortic and mitral valve (MV) operations have more than doubled over the past decade. We utilized the Society of Thoracic Surgeons Adult Cardiac Surgery Database (ACSD) to evaluate outcomes for patients undergoing combined aortic valve replacement (AVR) and MV repair or replacement. From 1993 to 2007, 23,404 patients undergoing ...
Mulder Bart A BA Department of Cardiology, University of Groningen, University Medical Center, Groningen, - - 2014
The atrial fibrillation (AF) Follow-up Investigation of Rhythm Management (AFFIRM) trial showed that digoxin was associated with increased mortality in patients with AF. To assess the association of digoxin with cardiovascular (CV) morbidity and mortality in patients with permanent AF enrolled in the Dutch RACE II trial. Additionally, to assess ...
Singh Jasvinder A JA Birmingham VA Medical Center, Birmingham, AL, USA, - - 2014
The objective of this study was to assess the time trends in utilization, clinical characteristics, and outcomes of patients undergoing total ankle arthroplasty (TAA) in the USA. We used the Nationwide Inpatient Sample (NIS) data from 1998 to 2010 to examine time trends in the utilization rates of TAA. We ...
Yohannan Jithin J Wilmer Eye Institute, Johns Hopkins University School of Medicine, 2124 E Baltimore St, Floor 2, Baltimore, MD, 21231, United - - 2014
Purpose: To detect spatial clustering of households with C. trachomatis infection (CI) and active trachoma (AT) in villages undergoing mass treatment with Azithromycin (MDA) over time. Methods: We obtained GPS coordinates for all households in four villages in Kongwa District, Tanzania. Every 6 months for a period of 42 months, ...
Augustine Daniel D Bristol Heart - - 2014
To define the characteristics of a real world population treated with transcatheter aortic valve implantation (TAVI) in a tertiary hospital and to evaluateclinical outcome. This includes in hospital morbidity rates and a comparison of 30 day, 1 year and 2 year mortality rates with those of the UK TAVI registry. ...
Nazri Shah Mohd SM Essex Cardiothoracic - - 2014
Mortality following ST-elevation myocardial infarction has declined significantly with the advent of primary PCI (PPCI). Concurrent use of antiplatelet agents has further decreased complication rates and mortality; however, these agents confer an increased bleeding risk, an independent risk factor for mortality. This retrospective study assesses the effect of blood loss ...
Kim Hye Won HW Department of Internal Medicine and AIDS Research Institutes, Yonsei University College of Medicine, Seoul, - - 2014
Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The ...
Alvin Matthew D MD *Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, USA †Case Western Reserve University School of Medicine, Cleveland, Ohio ‡Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA §Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA ∥Department of Neurological Surgery, Cleveland Clinic, Cleveland, Ohio, - - 2014
Retrospective 1-year cost-utility analysis. To determine the cost effectiveness of using rhBMP-2 in addition to autograft for one and two-level lumbar fusions. Recombinant human bone morphogenic protein-2 (rhBMP-2) has been studied extensively to identify its benefits, risks, patient outcomes, and costs relative to autograft (local bone or iliac crest bone ...
Dinov Borislav B Department of Electrophysiology, Heart Center, University of Leipzig, Leipzig, Germany - - 2014
-Recent studies reported worse outcomes after atrial fibrillation (AF) ablation in patients with metabolic syndrome (MetS). However, mechanisms of AF recurrence in MetS remain unclear. -We performed pulmonary vein isolation and voltage mapping in two hundred thirty-six AF patients (age 61±9.6 y.; persistent AF 64%, MetS 54%). LA low-voltage (LoVo) ...
Velasquez A A Leadership Preventive Medicine and Division of Critical Care, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, - - 2014
The aim of our study is to determine the short-term and long-term outcomes of intensive care unit (ICU) patients with minor troponin elevations. The retrospective study compared ICU patients with peak troponin elevation less than 0.1 ng/ml to those with only negative tests during their hospital stay. Data were gathered ...
Dharmarajan S - - 2014
In low-income countries, haemophilia treatment is not supported by national health services. Data on the burden of out-of-pocket (OOP) expenditure on households are unavailable from these countries. This study measured the OOP expenditure on treatment of haemophilia by Indian households. We used 20 weeks of follow-up data of 24 haemophilia ...
Selvarajah Shalini S Department of Surgery, Center for Surgical Trials and Outcomes Research (CSTOR), Johns Hopkins University School of Medicine, Baltimore, - - 2014
Racial disparities have been shown to be associated with increasing health-care costs. We sought to identify racial disparities in 30-d graft failure rates after infrainguinal bypass in an effort to define targets for improved health care among minorities. The 2005-2011 National Surgical Quality Improvement Program database was queried for patients ...
Ventham N T NT GI Unit, Centre for Genomics and Molecular Medicine, Western General Hospital, Edinburgh, - - 2014
Scottish nationwide linkage data from 1998 to 2000 demonstrated high 3-year mortality in patients hospitalised with ulcerative colitis (UC). To compare 3-year mortality, and factors related to mortality, in Scottish patients hospitalised with UC between 1998-2000 and 2007-2009. The Scottish Morbidity Records and linked datasets were used to assess 3-year ...
Inacio Maria C S MC Surgical Outcomes and Analysis, Kaiser Permanente, 8954 Rio San Diego Drive, Suite 406, San Diego, - - 2014
One year post-operative mortality among patients with primary elective total shoulder arthroplasty (ETSA) and traumatic shoulder arthroplasty (TSA) were compared to the general population of a large healthcare system. Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) were calculated. 614 ETSA patients, 1.0% one year mortality, and 168 TSA ...
Frederiksen Henrik H Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Department of Haematology, Odense University Hospital, Odense, - - 2014
Studies have reported a 1·3- to 2·2-fold higher mortality rate among patients with primary immune thrombocytopenia (ITP) compared to the general population. However, long-term mortality estimates as well as cause-specific mortality data are sparse. In our population-based cohort of adult patients with newly diagnosed ITP and up to 37 years of ...
Kim Young Dae YD Department of Neurology, Yonsei University College of Medicine, Seoul, - - 2014
Although early neurological deterioration (END) during the acute stroke period is known to be associated with poor functional outcomes, there is little data regarding the impact of END on long-term outcomes according to the characteristics of END. The aim of this study was to investigate whether there are differences in ...
Lemay Allyson C AC VERDICT research program, and South Texas Veterans Health Care System, Audie L. Murphy Division (MIR, EMM), University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Divisions of Hospital Medicine (ACL, EMM) and Pulmonary/Critical Care Medicine (MIR, AA), Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, - - 2014
Mortality rates after severe sepsis are extremely high, and the main focus of most research is short-term mortality, which may not be associated with long-term outcomes. The purpose of this study was to examine long-term mortality after a severe sepsis and identify factors associated with this mortality. The authors performed ...
Linke Axel A Department of Internal Medicine and Cardiology, University of Leipzig Heart Center, Struempellstrasse 39, 04289 Leipzig, - - 2014
Transcatheter aortic valve implantation has become an alternative to surgery in higher risk patients with symptomatic aortic stenosis. The aim of the ADVANCE study was to evaluate outcomes following implantation of a self-expanding transcatheter aortic valve system in a fully monitored, multi-centre 'real-world' patient population in highly experienced centres. Patients ...
Erturk Mehmet M Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, - - 2014
Peripheral arterial occlusive disease (PAOD), which is common in male gender and elderly population, is related with increased cardiovascular mortality and morbidity. Neutrophil to lymphocyte ratio (NLR) has been found to be an independent predictor of cardiovascular mortality in atherosclerosis. The aim of the present study was to investigate the ...
Alvin Matthew D MD *Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, USA †Case Western Reserve University School of Medicine, Cleveland, Ohio ‡Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA §Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA ∥Department of Neurological Surgery, Cleveland Clinic, Cleveland, Ohio, - - 2014
Retrospective 1-year cost-utility analysis. To determine the cost effectiveness of anterior cervical discectomy and fusion with plating (ACDFP) in comparison to posterior cervical foraminotomy (PCF) for patients with single-level cervical radiculopathy. Cervical radiculopathy due to cervical spondylosis is commonly treated by either PCF or ACDFP for patients who are refractory ...
Darmon Michael M 1 Medical ICU, Saint-Etienne University Hospital, Avenue Albert Raymond, Saint-Priest en Jarez, 42270, France; Jacques Lisfranc Medical School, Saint-Etienne University, Saint-Etienne, France 2 University of Grenoble 1 (Joseph Fourier) Integrated Research Center U 823 - Albert Bonniot Institute, Grenoble University Hospital, Grenoble, France 3 Polyvalent ICU, Grenoble University Hospital, BP217, 38043 Grenoble Cedex 9, France 4 Department of Physiology, Cochin University Hospital, APHP, 75005, Paris, France 5 Surgical ICU, Mondor University Hospital, APHP, 94000, Créteil, France 6 Medical ICU, University Hospital St Louis, 1 Avenue Claude Vellefaux, 75010, Paris, France 7 Medical ICU, Bichat University Hospital, Paris, France; Paris-7 University, Paris, France 8 Medical-Surgical ICU, Avicenne University Hospital, Bobigny, France; Paris-13 University, Bobigny, France 9 Polyvalent ICU, Groupe Hospitalier St Joseph, 145 Rue Raymond Losserand 75014, Paris, France 10 Medical ICU, Gabriel Montpied University Hospital, 58 Rue Montalembert, 63003 Clermont Ferrand Cedex 1, France 11 Polyvalent ICU, Gonesse General Hospital, 25 Rue Bernard Fevrier, 95500, Gonesse, France 12 Intensive care unit, Centre Hospitalier Andrée Rosemon, Av des Flamboyants, BP 6006 97306, Cayenne, France 13 Medical ICU, Hospices Civils de Lyon, Edouard Herriot University Hospital, F-69003 Lyon, France; Lyon University, Lyon-Est Medical School, F-69008, Lyon, France 14 Surgical ICU, Antoine Béclère University Hospital 157 Rue de la Porte de Trivaux, 92141, Clamart Cedex, France 15 Polyvalent ICU, Centre Hospitalier Sud Essonne Dourdan-Etampes - Siège, 26 Avenue Charles de Gaulle, 91150, Etampes, France 16 Medical-Surgical ICU, Hyeres hospital, Hyeres, Frances 17 Surgical ICU, Edouard Herriot University Hospital, Hospices Civiles de Lyon, Lyon, - - 2014
Increasing evidence suggests that dysnatraemia at ICU admission may predict mortality. Little information is available, however, on the potential effect of dysnatraemia correction.Patients and MethodsObservational multicentre cohort study in patients admitted between 2005 and 2012 to 18 French ICUs. Hyponatraemia and hypernatraemia were defined as serum sodium concentration < 135 ...
Miric Alexander A Department of Orthopaedic Surgery, Southern California Permanente Medical Group, Los Angeles, - - 2014
As the nonagenarian patient population continues to grow, more patients aged 90 and over will become candidates for total knee arthroplasty (TKA). This study evaluated the patient characteristics and incidence of postoperative morbidity and mortality of 216 nonagenarian TKA patients among 81,835 primary TKA patients followed by a total joint ...
Rinewalt Daniel D Division of Cardiac Surgery, Martha and Richard Melman Family Bicuspid Aortic Valve Program, Bluhm Cardiovascular Institute, Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
Bicuspid aortic valve (BAV) disease is associated with aortic dilatation and aneurysm (AN) formation. The American College of Cardiology/American Heart Association (ACC/AHA) 2006 guidelines recommend replacement of the ascending aorta for an aortic diameter (AD) > 45 mm in patients undergoing aortic valve replacement (AVR). We evaluated the outcomes of ...
Caceres Manuel M Division of Cardiothoracic Surgery, Cedars Sinai Medical Center, Los Angeles, CA, - - 2014
Aortic root surgery is transitioning to aortic valve sparing (AVS), but little is known about the relative early outcomes of AVS versus composite graft-valve replacement (CVR). This study assessed mortality differences for AVS versus CVR to guide future practice decisions. From January 2000 to June 2011, 31 747 patients had ...
Ahmadi Zainab - - 2014
The prognostic role of the arterial blood gas tension of carbon dioxide (PaCO2) in severe Chronic Obstructive Pulmonary Disease (COPD) remains unknown. The aim of this study was to estimate the association between PaCO2 and mortality in oxygen-dependent COPD. National prospective study of patients starting long-term oxygen therapy (LTOT) for ...
Firempong Alexander O - - 2014
Objectives: Septic shock (SS) and respiratory failure (RF) are serious complications after neurosurgical procedures. Research is limited in studying racial/ethnic disparities in incidence and mortality of SS and RF. The study aimed to determine the racial variation in incidence and mortality from SS and RF among elective neurosurgical patients in ...
Thorsen Kenneth K Department of Gastrointestinal Surgery, Stavanger University Hospital, PO Box 8100, 4068, Stavanger, Norway, - - 2014
Mortality rates in perforated peptic ulcer (PPU) have remained unchanged. The aim of this study was to compare known clinical factors and three scoring systems (American Society of Anesthesiologists (ASA), Boey and peptic ulcer perforation (PULP)) in the ability to predict mortality in PPU. This is a consecutive, observational cohort ...
Ashebo Gedeon Yohannes - - 2014
Information is needed on the expected durability of insecticidal nets under operational conditions. The persistence of insecticidal efficacy is important to estimate the median serviceable life of nets under field conditions and to plan for net replacement. Deltamethrin residue levels were evaluated by the proxy method of x-ray fluorescence spectrometry ...
Unbehaun Axel A Deutsches Herzzentrum Berlin, Berlin, - - 2014
A major limitation of transcatheter aortic valve implantation (TAVI) is that its long-term outcomes are still unknown. The purpose of this study was to evaluate survival up to 5 years after implantation and to identify predictors of follow-up mortality in a large cohort of patients who underwent exclusively a transapical ...
O'Byrne Michael - - 2014
Nonvariceal upper gastrointestinal bleeding (NVUGIB) is associated with significant mortality. To examine several factors that may impact the mortality and 30-day rebleed rates of patients presenting with NVUGIB. A retrospective study of the charts of patients admitted to hospital in either the Saskatoon Health Region (SHR) or Regina Qu'Appelle Health ...
Borges Ana A Faculdade de Medicina. Universidade do Porto. Porto. Portugal.. - - 2014
Introduction: Intertrochanteric fractures incidence has been increasing over the past few years and therefore so have all the problems associated with it. It is important to search for possible ways to reduce comorbidities as well as postoperative mortality. We decided to assess the impact of some routine pre-operative analytical values ...
Tadros Rami O RO Division of Vascular Surgery, Department of Surgery, The Ichan School of Medicine at Mount Sinai, New York, NY. Electronic address: - - 2014
There have been four eras in the development of endovascular aneurysm repair (EVAR): physician-made grafts, early industry devices, intermediary commercial endografts, and modern stent grafts. This study analyzes differences in outcomes between these four groups and the impact of device evolution and increased physician experience. From 1992 to 2012, 1380 ...
Hennig A A Sagarmatha Choudhary Eye Hospital, Lahan, - - 2014
PurposeTo compare the outcomes of phacoemulsification with either a 2.5-mm clear corneal incision and a foldable intraocular lens (IOL) or a 5-mm sclerocorneal tunnel incision and a rigid polymethyl methacrylate (PMMA) IOL.MethodsIn a prospective, randomised clinical trial of phacoemulsification cataract surgery, 1200 patients received either a foldable hydrophilic acrylic IOL ...
Sebag Frédéric A FA Department of Cardiology, Henri Mondor Hospital (Assistance Publique-Hôpitaux de Paris), Creteil, - - 2014
To evaluate the prognostic impact of QRS width in patients with low-flow/low-gradient aortic stenosis (LF/LGAS). Among 88 consecutive patients referred to our institution for LF/LGAS from September 1994 to March 2007, baseline demographic, clinical, echocardiographic, and electrocardiographic data were collected. This population was divided into two groups according to baseline ...
Tuttle John R JR Department of Orthopaedics, Brown University Alpert School of Medicine, Providence, Rhode - - 2014
The purpose of this study was to provide a cost-benefit analysis of topical tranexamic acid (TXA) in primary total hip and knee arthroplasty patients. A retrospective cohort of 591 consecutive patients, 311 experimental and 280 control, revealed a transfusion rate reduction from 17.5% to 5.5%, increased postoperative hemoglobin, and decreased ...
Rollins K E KE Cambridge Vascular Unit, Box 201, Level 6, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, - - 2014
Emergency endovascular repair (EVAR) for ruptured abdominal aortic aneurysm (rAAA) may have lower operative mortality rates than open surgical repair. Concerns remain that the early survival benefit after EVAR for rAAA may be offset by late reinterventions. The aim of this study was to compare reintervention rates and cost-effectiveness of ...
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