Search Results
Results 451 - 500 of 1265
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Czepielewski Mauro A - - 2007
We review the clinical and biochemical criteria used for evaluation of the transsphenoidal pituitary surgery results in the treatment of Cushing's disease (CD). Firstly, we discuss the pathophysiology of the hypothalamic-pituitary-adrenal axis in normal subjects and patients with CD. Considering the series published in the last 25 years, we observed ...
Rollin Guilherme - - 2007
Transsphenoidal pituitary surgery (TSS) remains the treatment of choice for Cushing's disease (CD). Despite the widespread acceptance of this procedure as the first line treatment in CD, the indication of a second TSS in not cured or relapsed DC patients is not consensus. We report the results of TSS in ...
Dekkers O M - - 2008
CONTEXT: Several studies have assessed mortality risk in patients treated for acromegaly. All studies found a mortality that was higher than expected for the general population, but most of these increases were not statistically significant. For this reason, it is not formally established whether mortality in acromegaly is different from ...
Klose M - - 2007
OBJECTIVE: To assess the prevalence of hypopituitarism following traumatic brain injury (TBI), describe the time-course and assess the association with trauma-related parameters and early post-traumatic hormone alterations. DESIGN: A 12-month prospective study. PATIENTS: Forty-six consecutive patients with TBI (mild: N = 22; moderate: N = 9; severe: N = 15). ...
Shah Jay B - - 2007
BACKGROUND AND PURPOSE: There have been no large case series reporting on the success of percutaneous transparenchymal endocystolysis for obstructing parapelvic renal cysts. We report the largest series to date with 5-year outcomes. PATIENTS AND METHODS: Percutaneous endocystolysis was performed in eight patients with obstructing parapelvic cysts between September 1998 ...
Zerem Enver - - 2008
To evaluate whether prolonged catheter drainage with negative pressure yields better results than single-session alcohol sclerotherapy in the treatment of symptomatic non-parasitic benign liver cysts. Forty patients were randomly assigned to two groups in a 24-month prospective controlled trial. One group was treated with ultrasound-guided prolonged catheter drainage with negative ...
Navarro Fernando A - - 2007
OBJECTIVES: To determine whether long-term low-dose prednisone (LTLDP) therapy has a decelerating effect on growth velocity and whether this therapy is effective in the maintenance of remission in the subgroup of pediatric patients with Crohn disease (CD) who had previously experienced flares on more than 1 occasion when prednisone was ...
Shah Rupali - - 2007
BACKGROUND: Thyroglossal duct cysts (TGDCs) are the most common form of congenital neck cyst, accounting for up to 70% of such lesions. There has been no consensus on which factors predict outcome of thyroglossal duct cyst excision. The objective of the current study is to evaluate the relevance of symptomatology ...
Adler A - - 2008
BACKGROUND AND AIMS: Colonoscopy is an established method of colorectal cancer screening, but has an adenoma miss rate of 10-20%. Detection rates are expected to improve with optimised visualisation methods. This prospective randomised study evaluated narrow-band imaging (NBI), a new technique that may enhance image contrast in colon adenoma detection. ...
Murat Vakeli - - 2007
Between 1978 and 2002, 15 patients (mean age, 23.0 +/- 8.5 years) with cardiac and pericardial echinococcosis were treated surgically. The cysts were located in the right atrium in 3 patients, on the anterior myocardium in 7, and pericardially in 5. The 3 patients with right atrial cysts were operated ...
Buchfelder Michael - - 2007
OBJECTIVE: Several studies documented metabolic and psychological benefits of GH substitution in deficient adults, most of them suffering from benign pituitary adenomas. Since GH substitution is considered to promote tumour regrowth, adequate treatment is performed with some reservation. Therefore, we aimed to elucidate the effect of GH replacement therapy on ...
Rudnik Adam - - 2007
AIM OF THE STUDY: The paper presents endoscopic surgical technique used in the treatment of hormonally active pituitary adenomas and assessment of the method in terms of its effectiveness and safety. MATERIAL AND METHODS: In 217 cases the surgery was performed due to pituitary adenomas applying the technique developed by ...
Kashiwabara Moto - - 2007
The hypothalamic-pituitary-adrenal axis is an essential component for the maintenance of homeostasis following trauma. Major surgical trauma often induces overwhelming inflammatory responses leading to sepsis and organ dysfunction. This study was designed to evaluate the adrenal responses both before and after various degrees of surgical trauma and to determine the ...
Fleseriu Maria - - 2007
PURPOSE OF REVIEW: Adenectomy via transsphenoidal surgery is considered the treatment of choice for Cushing's disease. It is successful in about 80% of patients in the hands of an experienced surgeon. When transsphenoidal surgery fails or is contraindicated, a second-line treatment must be chosen. The review focuses on second-line treatment ...
Zhang Xiang - - 2007
Hemorrhagic pituitary adenoma (HPA) is an acute clinical event in neurosurgery. Emergency surgical decompression is the most effective treatment. We retrospectively reviewed 65 cases collected from the Xijing Institute of Clinical Neuroscience from 1995 to 2005 with HPA. The majority of the patients (81.5%) experienced the acute symptoms of pituitary ...
Bakker B - - 2007
OBJECTIVE: In January 1997 we introduced a protocol for the treatment with GH of children with impaired growth after unfractionated total body irradiation (TBI). This study is an evaluation of that protocol. PATIENTS AND METHODS: Between January 1997 and July 2005, 66 patients (48 male) treated for haematological malignancies had ...
Hayashi Motohiro - - 2007
PURPOSE: To evaluate outcomes after pituitary radiosurgery in patients with post-stroke thalamic pain syndrome. METHODS AND MATERIALS: From 2002 to 2006, 24 patients with thalamic pain syndrome underwent pituitary radiosurgery at Tokyo Women's Medical University and were followed at least 12 months thereafter. The radiosurgical target was defined as the ...
Jallad Raquel S - - 2007
OBJECTIVE: To compare the intrapatient response to the same dose of slow-release octreotide (OCT-LAR) before and after noncurative surgery in acromegalic patients who did not attain disease control after primary treatment with OCT-LAR. DESIGN: Prospective clinical study. PATIENTS: Eleven acromegalic patients (eight men, aged 42.45 +/- 11.15 years, 10 macroadenomas) ...
Guo Dongsheng - - 2007
OBJECTIVE: The aim of this study was to investigate the microsurgical results of symptomatic sacral perineurial cysts of 11 patients and to discuss the treatment options of the past 10 years. METHODS: We retrospectively reviewed the records of 11 patients with symptomatic sacral perineurial cysts who underwent microsurgical treatment at ...
Mishra Anand Kumar - - 2007
Adrenalectomy continues to play an important role in the management of Cushing's syndrome (CS). Untreated CS causes considerable physical and mental morbidity and mortality. However, little information is available on the effect of adrenalectomy in ameliorating functional disabilities in CS patients. Our study assesses the long-term outcome of adrenalectomy in ...
Bechtold Susanne - - 2007
BACKGROUND: GH treatment stimulates growth in short children with juvenile idiopathic arthritis (JIA). The extent to which this therapy increases final height is not known. METHODS: Thirty-one growth-retarded children with systemic and polyarticular idiopathic arthritis were enrolled in this controlled study. After a mean observational time of 8.4 yr, final ...
Chanson P - - 2007
Medical treatment of hyperprolactinemia is based upon use of dopamine agonists (DA): bromocriptine, lisuride, quinagolide and cabergoline. In over 80% of cases, these drugs induce normal prolactinemia and ovulatory cycles. In resistant cases, the DA should be changed. Tolerance may occasionally be poor, particularly with bromocriptine, which appears less well-tolerated ...
Yetkin Demet Ozgil - - 2007
The objective of the present study was to investigate the effects of octreotide long acting release (S-LAR) preparation on GH and IGF-1 serum concentrations and pituitary tumor size in patients with persistent and difficultly controlled acromegaly even after adjuvant irradiation and/or dopamine agonists. Thirty-three patients with active acromegaly (26 female ...
Rohana A - - 2007
Introduction Adrenal surgery in our institution has evolved from open surgery to laparoscopic approach. The aim of this paper was to evaluate the feasibility and changes in the practice of adrenal surgery. Methods A total of 129 consecutive patients who had adrenal surgery from October 1998 to 2006 were included ...
Lienert Andrew - - 2007
BACKGROUND: Surgical resection has been the standard treatment for duodenal adenomas. It has a high associated morbidity rate and a significant recurrence rate. The aim of this study was to evaluate endoscopic treatment of these lesions with argon plasma coagulation. METHODS: We retrospectively identified patients with non-ampullary duodenal adenomas without ...
Akhan Okan - - 2007
The purpose of this study is to demonstrate and discuss the radiological features of four patients with muscular hydatid disease and to evaluate the results of percutaneous treatment in these patients. Four patients (three female and one male) with six muscular hydatid cysts underwent percutaneous treatment and were followed up. ...
Charalampaki Patra - - 2007
OBJECTIVE: Microsurgical transsphenoidal surgery for pituitary tumors has been standard therapy for decades and was established by Harvey Cushing in the early twentieth century. Today, endoscopy is increasingly accepted in the therapy of pituitary lesions. In this retrospective study, we analysed the surgical technique and outcome of 50 patients with ...
Morcos M - - 2007
CONTEXT: Central Cushing's syndrome is not always curable by surgery or radiation of the pituitary. Medical treatment is often not possible or effective. Some studies revealed beneficial effects of the PPARgamma (Peroxisome-Proliferator-Activator- Receptor-gamma)-agonist rosiglitazone (RG) in in vitro studies, animal models and short term clinical studies. OBJECTIVE: of this study ...
Grieser Eric J - - 2007
PURPOSE: To report the benign seven year follow-up on a free-floating anterior chamber epithelial inclusion cyst that did not require treatment. DESIGN: Retrospective observational case report. METHODS: Seven years of clinical observation of a patient who had radial keratotomy in 1998. RESULTS: The free-floating cyst showed no growth or untoward ...
Thompson Sarah K - - 2007
To determine long-term quality of life after bilateral adrenalectomy for persistent Cushing's disease after transsphenoidal pituitary tumor resection. Bilateral adrenalectomy for symptomatic relief of persistent hypercortisolism appears to be an effective treatment option. However, few studies have examined long-term outcomes in this patient population. Retrospective review of 39 patients treated ...
Mercado Moises - - 2007
To evaluate the efficacy, safety and tolerability of octreotide LAR (long-acting repeatable octreotide) in the primary therapy of acromegaly. Ninety-eight previously untreated acromegalics were recruited into this prospective multicentre study. A total of 68 patients successfully completed 48 weeks of the study period, received 12 doses of octreotide LAR 10-30 ...
Leonhartsberger Nicolai - - 2007
OBJECTIVE: To assess a possible development of antisperm antibodies (ASA), present in a high percentage of infertile patients, after organ-sparing surgery for small testicular tumours, to identify any additional immunogenic effect of this procedure compared with standard orchidectomy. PATIENTS AND METHODS: Samples of sera were assessed from 54 men who ...
Chan L F - - 2007
BACKGROUND/OBJECTIVE: Pituitary radiotherapy (RT) is an effective second-line treatment for paediatric Cushing's disease (CD). Although the short-term effects of pituitary RT are well documented, there are less data on possible long-term sequelae. We report the long-term anterior pituitary function in a cohort of paediatric CD patients treated with pituitary RT. ...
Horn Eric M - - 2007
OBJECTIVE: We retrospectively reviewed our experience treating third ventricular colloid cysts to compare the efficacy of endoscopic and transcallosal approaches. METHODS: Between September 1994 and March 2004, 55 patients underwent third ventricular colloid cyst resection. The transcallosal approach was used in 27 patients; the endoscopic approach was used in 28 ...
Ronchi Cristina L - - 2007
OBJECTIVE: Some authors proposed to lower the present postglucose GH nadir cut-off (i.e. < 1 microg/l) to that obtained in healthy subjects to establish remission of acromegaly. The aim of the study was to correlate GH nadir with hormonal and metabolic parameters and to confirm the adequacy of the current ...
Challacombe Ben - - 2007
BACKGROUND AND PURPOSE: Retroperitoneoscopic nephrectomy (RN) for giant hydronephrosis (GH) is regarded as a more challenging procedure than RN for small nonfunctioning kidneys (SNFK). We describe specific technical modifications to facilitate surgery in the GH group and compare outcomes in the two groups. PATIENTS AND METHODS: Data were collected in ...
Colao Annamaria - - 2007
Limited data are available on clinical presentation and treatment strategy in patients with GH-secreting adenomas with onset in adolescence. To report results of diagnosis and treatment in adolescents with GH and IGF-I excess. Analytical, observational, retrospective. Thirteen patients (five females and eight males, age 15-20 years) all with macroadenoma (two ...
Das N Kumar - - 2007
BACKGROUND: Cushing's disease may have a direct effect on growth pattern, pubertal maturation, and long-term survival in pediatric patients. METHODS: Dexamethasone suppression test was done in 10 children (median age, 15 years) and showed variable suppressibility, with microadenoma seen in 5, macroadenoma in 3, and normal gland in 2 patients. ...
Bildik Nejdet - - 2007
PURPOSE: Hydatid cyst is still a significant health and economical problem due to insufficient preventive measures. Infestation by hydatid disease in humans most commonly occurs in the liver and causes complications unless treated properly. Therefore, hepatic hydatid cyst should immediately be treated when diagnosed. Today, the treatment of hydatid cysts ...
Shimon Ilan - - 2007
To review our experience with cabergoline, a D2-selective dopamine agonist, for the treatment of giant prolactinomas. A retrospective case series; descriptive statistics. The study group included 12 men aged 24-52 years (mean 39.2 years) treated for giant prolactinoma at our centers from 1997 to 2006. Cabergoline was started at a ...
Capalbo Silvana - - 2007
Osteonecrosis of the jaw (ONJ) has been reported as uncommon but well recognised complication associated with bisphosphonate treatment. Multiple Myeloma (MM) is the pathology most frequently associated with ONJ in the medical and dental papers published over the last years (45% of the ONJ published cases). ONJ appears to be ...
Darendeliler Feyza - - 2007
BACKGROUND: Several uncommon adverse effects may be related to growth hormone (GH) treatment. Three potential side effects, headache, idiopathic intracranial hypertension (IIH) and slipped capital femoral epiphysis (SCFE), will be discussed. Data from 57,968 children in the KIGS (Pfizer International Growth Study database) were analyzed to determine the effects of ...
Jallad Raquel S - - 2007
OBJECTIVE: To evaluate efficacy and safety of radiotherapy on acromegaly treatment. DESIGN AND PATIENTS: We followed retrospectively 99 acromegalic patients for at least one year after radiotherapy (RT). RT had been performed after unsuccessful surgery in 91 patients and as primary treatment in eight. Time elapsed between surgery and RT ...
Patil Chirag G - - 2007
OBJECT: Information about complications, patient outcomes, and mortality rate after transsphenoidal surgery (TSS) for Cushing's disease has been derived largely from single-institution series. In this study the authors report on inpatient death, morbidity, and outcomes following TSS for Cushing's disease on a national level. METHODS: All patients in the Nationwide ...
Bhat H Sanjay - - 2007
OBJECTIVE: Laparoscopic adrenalectomy (LA) has become the established procedure for adrenal masses less than 6 cm. The role of LA for large adrenal masses is well defined to a lesser extent. METHODS: Thirty-six LAs were performed in 32 patients (including four patients with single stage bilateral adrenalectomies) over a period ...
Moncet Daniel - - 2007
Cushing's syndrome (CS) is a serious condition requiring drug management in diverse clinical settings. Fifty four patients (44 females, 10 males) with CS, aged 14-63, received ketoconazole (KTZ) prior to surgery (n= 27), as complementary therapy after surgery and/or radiotherapy (n= 16), or as primary treatment (n= 11). It was ...
BarczyƄski Marcin - - 2007
BACKGROUND: Today, the posterior retroperitoneoscopic technique has become a standard procedure in adrenal surgery. The procedure allows direct access to the adrenal glands, but it seems to be difficult because of the uncommon anatomic view. This study compares the learning period of the new procedure of "posterior retroperitoneoscopic adrenalectomy" in ...
van den Bergh Alfons C M - - 2007
PURPOSE: To demonstrate the benefit of immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma (NFA) in perspective to the need for hormonal substitution and life expectancy. METHODS AND MATERIALS: Retrospective cohort analysis of 122 patients, operated for NFA between 1979 and 1998. Recurrence was defined as regrowth on computed tomography ...
Bolanowski Marek - - 2006
OBJECTIVES: Acromegaly is a rare disease with increased mortality rate. The aim was to present our centre experience in the diagnosis and treatment of a series of patients suffering from acromegaly. METHODS: 130 patients (55 men, 75 women) aged 19-84 years presenting with clinical and hormonal features of acromegaly, attending ...
Steelman Joel - - 2006
The North American (US and Canada) GHMonitor was initiated to assess the safety and efficacy of Saizen (somatropin [recombinant human growth hormone for injection]) for growth disorders. Between 2003 and 2005, 1057 patients were enrolled in the registry; there were more males than females (67% vs 32%), the median age ...
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