Search Results
Results 251 - 300 of 8216
< 1 2 3 4 5 6 7 8 9 10 11 >
Tsuboi Kazuya K LSD Center and Hematology, Nagoya Central Hospital, Nagoya, - - 2014
Background:Between 2009 and 2012, there was a worldwide shortage of agalsidase-β for the treatment of Fabry disease. Therefore, alternative treatments were needed, including switching to a different enzyme-replacement therapy.Purpose:This is an ongoing observational study assessing the effects of switching from agalsidase-β (1.0 mg/kg every other week) to agalsidase-α (0.2 mg/kg every other ...
Tanaka H H 1Department of Pediatrics, Hirosaki University - - 2014
BackgroundRecent advances in the management of lupus nephritis (LN) have also contributed to a favorable outcome in patients with pediatric-onset LN. Nevertheless, we believe that a more effective and less toxic treatment is needed to attain optimal control of pediatric-onset LN.MethodsSeven consecutive children with biopsy-proven LN (four with class III/IV ...
Dreher T T Division for Paediatric Orthopaedics and Foot Surgery, Department for Orthopaedic and Trauma Surgery, Heidelberg University Clinics, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany. Email addresses for T. Dreher: thomas_dreher@hotmail.com; - - 2014
The foot drop component of cavovarus foot deformity in patients with Charcot-Marie-Tooth disease is commonly treated by tendon transfer to provide substitute foot dorsiflexion or by tenodesis to prevent the foot from dropping. Our goals were to use three-dimensional foot analysis to evaluate the outcome of tibialis posterior tendon transfer ...
Elsone Liene L The Walton Centre NHS Foundation Trust, - - 2014
Azathioprine (AZA) is a common immunosuppressive drug used for relapse prevention in neuromyelitis optica (NMO). The objective of this paper is to assess efficacy, tolerability and retention of AZA in a large NMO cohort. We conducted a retrospective review of medical records of 103 aquaporin-4 antibody-positive NMO and NMO spectrum ...
Dilsiz Alparslan A Department of Periodontology, Faculty of Dentistry, Atatürk University , Erzurum , - - 2014
Abstract Objective. The main goal of periodontal treatment is to control infection and, thereby, curb disease progression. Recent studies have suggested that the use of a laser as an adjunct to scaling and root planing (SRP) might improve the effectiveness of conventional periodontal treatment. The aim of this study was ...
Abarzúa-Araya Alvaro A Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: - - 2014
Infantile hemangiomas have a dramatic response to propranolol, a nonselective beta-blocker. However, this treatment is not risk-free and many patients are excluded because of respiratory comorbidities. Atenolol is a cardioselective beta-blocker that may have fewer adverse events. We sought to evaluate the effectiveness of atenolol against propranolol in a noninferiority ...
Templeton Arnoud J AJ Breast Centre, St. Gallen, Switzerland. Electronic address: - - 2014
Elevated concentrations of doxorubicin are found in eccrine sweat glands of the palms and soles. We therefore evaluated an antiperspirant as preventive treatment for palmar-plantar erythrodysesthesia (hand-foot syndrome) in patients with metastatic breast cancer treated with pegylated liposomal doxorubicin. An antiperspirant containing aluminum chlorohydrate or placebo cream was applied to ...
Potts Matthew B MB Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, - - 2014
To describe a single institution's experience treating arteriovenous malformations (AVMs) of the basal ganglia, thalamus, and insula in a multimodal fasion. We conducted a retrospective review of all deep AVMs treated at our institution between 1997-2011 with attention to patient selection, treatment strategies, and radiographic and functional outcomes. 97 patients ...
Mestres Gaspar - - 2014
Objective: Steal syndrome is a severe complication of vascular access. Our aim is to present the initial results of a simple and effective treatment: the interposition of a prosthetic segment in the juxta-anastomotic vein. Method: Between 2009 and 2012, 14&nbsp;patients (57&nbsp;% male, average age&nbsp;71) with severe steal syndrome due to ...
Faranoush M M 1High Institute of Research, Iranian Blood Transfusion Organization, Iran University of Medical Sciences, Rasool Akram Hospital, Tehran, - - 2014
In order to establish the efficacy and biosimilar nature of AryoSeven to NovoSeven in the treatment of congenital factor VII (FVII) deficiency, patients received either agent at 30 μg/kg, intravenously per week for 4 weeks, in a randomized fashion. The primary aim was to compare FVII:coagulation activity (FVII:C), 20 minutes ...
Joloba Moses L ML Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda. Electronic address: - - 2014
We conducted a prospective study to determine which solid medium is the most reliable overall and after two months of therapy to detect Mycobacterium tuberculosis complex (MTB). MTB isolation and contamination rates on LJ and Middlebrook 7H10 and 7H11 agar with and without selective antibiotics were examined in a single ...
Raeissadat Seyed Ahmad - - 2014
Lateral humeral epicondylitis, or 'tennis elbow', is a common condition with a variety of treatment options. Platelet-rich plasma (PRP) and Autologous Whole Blood(AWB) represent new therapeutic options for chronic tendinopathies including tennis elbow. The aim of the present study was to compare the long term effects of PRP versus autologous ...
Sun Jing-Hai JH The 208th Hospital , Changchun , China - - 2014
Abstract Context: The chemical weapon sulfur mustard (SM) is a blister agent, and currently, there is no effective antidote. Objective: To evaluate the decontamination efficacy of potassium ketoxime against SM and preliminarily elucidate its decontamination mechanism. Materials and methods: Potassium ketoxime reacted with SM, and SM residues were tested at ...
Bijlsma Johannes W J JW Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the - - 2014
Glucocorticoids (GCs) have been used for over 65 years in the treatment of rheumatoid arthritis (RA). There is by now good evidence for their disease-modifying effects, especially in early RA. When used in a dosage of 5-10 mg, most adverse effects can adequately be monitored, though accurate monitoring and awareness ...
Siedner Mark J MJ Division of Infectious Diseases, Massachusetts General Hospital, Boston, - - 2014
Background. Carbapenems are recommended for treatment of Enterobacter infections with AmpC phenotypes. Although isolates are typically susceptible to cefepime in vitro, there are few data supporting its clinical efficacy. Methods. We reviewed all cases of Enterobacter species bacteremia at two academic hospitals from 2005-2011. Outcomes of interest were: a) persistent bacteremia &sup3; ...
Chung-Delgado Kocfa K Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru; Sociedad Científica de Estudiantes de Medicina (SOCIEMUPC), Universidad Peruana de Ciencias Aplicadas, Lima, - - 2014
We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. This was a retrospective cohort study. The data of patients commencing MDR-TB therapy were analyzed. Data were collected from different public TB treatment facilities located in peri-urban areas ...
Yi Xingyang X Department of Neurology, People's Hospital of Deyang City, Deyang 618000, Sichuan, - - 2014
We evaluated the efficacy of low-molecular-weight heparin (LMWH) relative to aspirin in preventing early neurologic deterioration (END), venous thromboembolism (VTE), and outcomes at 6 months. Patients were randomly assigned to receive either subcutaneous enoxaparin 4000 anti-factor Xa IU/0.4 mL twice daily or oral aspirin 200 mg daily for 10 days. After day 10, all ...
Lim Eun-Hwa EH Department of Dermatology, School of Medicine, Chungnam National University, - - 2014
Traditional pharmacotherapy for onychomycosis has low to moderate efficacy and may be associated with adverse reactions and medication interactions limiting its use in many patients. We evaluated the clinical efficacy and safety of a fractional carbon-dioxide laser with topical antifungal therapy in the treatment of onychomycosis. In all, 24 patients ...
Giovannoni Gavin G Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Electronic address: - - 2014
In the SELECT trial, disease activity was reduced in patients with multiple sclerosis who received daclizumab high-yield process (HYP) for 52 weeks. The primary aim of the SELECTION extension study was to assess the safety and immunogenicity of extended treatment with daclizumab HYP. A multicentre, randomised, double-blind, 52-week extension trial ...
Rujirojindakul P P Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, - - 2014
This study aimed to determine the safety and efficacy of intraoperative intensive glycaemic treatment with modified glucose-insulin-potassium solution by hyperinsulinemic normoglycaemic clamp in cardiopulmonary bypass surgery patients. We hypothesised that the treatment would reduce infection rates in this group of patients. A prospective, randomised, double-blind trial was conducted in cardiopulmonary ...
Sakai Yoshiyuki Y Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, - - 2014
The usefulness of branched-chain amino acid (BCAA) granules and BCAA-enriched nutrient mixtures for patients with liver cirrhosis is often reported. However, no randomized controlled studies have investigated the usefulness of these supplements in the nutritional intervention of cirrhotic patients receiving endoscopic treatment for esophageal varices. Patients without BCAA before endoscopic ...
Ambler Graeme K GK Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 - - 2014
Symptomatic peripheral arterial disease may be treated by a number of options including exercise therapy, angioplasty, stenting and bypass surgery. Atherectomy is an alternative technique where atheroma is excised by a rotating cutting blade. The objective of this review was to analyse randomised controlled trials comparing atherectomy against any established ...
Fan Chuanfeng C Department of Ophthalmology, Shandong Provincial Hospital, Shandong University , Jinan, Shandong , PR China - - 2014
Abstract Purpose: To compare visual outcomes and spectral-domain optical coherence tomography results following treatment with intravitreal ranibizumab (IVR) or IVR combined with intravitreal triamcinolone acetonide (IVTA) for macular edema (ME) secondary to central retinal vein occlusion (CRVO). Methods: This prospective, case-controlled study examined 57 eyes (57 patients) with ME secondary ...
Zhenbo Zuo Z Department of Trauma, Affiliated Hospital of Qingdao University, Qingdao, PR - - 2014
Because recurrent peroneal subluxation can produce functional impairment in athletes, most authors suggest operative intervention for patients who fail nonoperative treatment. The present report introduces the modified sliding fibular graft repair for this pathology. This retrospective study was conducted to analyze the clinical results for 26 patients with recurrent peroneal ...
Karkos Petros D PD Department of Otolaryngology, Queen Alexandra Hospital, Portsmouth, - - 2014
Vocal process granulomas (VPGs) are benign laryngeal lesions with controversial treatment and a tendency to recur. There are several treatment options with unpredictable results, high recurrence rates, and disappointing long-term outcome. The aims of this article are to focus on evidence-based current treatment strategies for primary lesions and recurrences. The ...
Cho Hyung H Ophthalmic Consultants of Boston, Boston, Massachusetts - - - 2014
Purpose: Intravitreal aflibercept, a fusion protein with high affinity for vascular endothelial growth factor, offers an alternative treatment for exudative age-related macular degeneration. Preclinical studies and early and late phase clinical trials suggest that aflibercept's high binding affinity may impart greater durability of activity and increased efficacy compared to ranibizumab ...
Safinaz M K MK Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaakob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, - - 2014
The purpose of this study was to compare the use of autologous fibrin to human amniotic membrane (HAM) as a scaffold in cultivating autologous conjunctiva for transplantation in treatment of conjunctival defect. An experimental study was performed using 18 adult New Zealand white strain rabbits which were divided into 3 ...
Florescu Marius C MC Nephrology Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, - - 2014
There are limited data regarding endovascular treatment of arteriovenous graft (AVG) pseudoaneurysms using stent grafts. We performed a comprehensive literature review on the use of stent grafts in the treatment of AVG pseudoaneurysms. We included 10 studies (121 patients). The mean AVG age was 3.1 years (95% confidence interval [CI]: ...
Khogali Mohammed M Médecins sans Frontières, Medical Department (Operational Research Unit/Operations), Brussels Operational Centre, MSF-Luxembourg, - - 2014
In the Somali Regional State, Ethiopia, where most of the population are pastoralists, conventional TB treatment strategies based on directly observed treatment (DOT) at health facilities are not adapted to the mobile pastoralist lifestyle and treatment adherence is poor. From a rural district, we report on treatment outcomes of a ...
Derrey S S Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, - - 2014
Giant intracranial aneurysms represent a major therapeutic challenge for each surgical team. The aim of our study was to extensively review the French contemporary experience in treating giant intracranial aneurysms in order to assess the current management. This retrospective multicenter study concerned consecutive patients treated for giant intracranial aneurysms (2004-2008) ...
Sun Yapeng Y Department of Spine Surgery, The Third Hospital of HeBei Medical University, Shijiazhuang, 050051, - - 2014
To evaluate the clinical outcome of two different surgical treatments in treating degenerative scoliosis. Forty patients with degenerative scoliosis hospitalized in our department from June 2010 to June 2012 were selected. They were randomly divided into two groups. The first group was performed on the points with nerve or spinal ...
Hamad S S Department of Respiratory Medicine, AMNCH Hospital, Tallaght, Dublin, 24, Ireland, - - 2014
Optimisation of patient comfort during flexible bronchoscopy is achieved with the use of intravenous sedation and vocal anaesthesia. The effect of transcricoid lignocaine injection was investigated with regards to ease of procedure and frequency of cough. A single-blinded study was carried out and two visual analogue scales were used as ...
Vanacker Peter P Neurology Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Neurology, University Hospital Antwerp, - - 2014
Recanalization in acute ischemic stroke with large vessel occlusion is a potent indicator of good clinical outcome. to identify easily available clinical and radiological variables predicting recanalization at various occlusion sites. All consecutive, acute stroke patients from ASTRAL registry (2003-2011) who had a large vessel occlusion on CT angiography (<12hours) ...
Berkel A E M AE Department of Surgery, Medisch Spectrum Twente, Enschede, The - - 2014
Nitric oxide donors, such as isosorbide dinitrate ointment (ISDN), are considered as first choice agents in the treatment of chronic anal fissure. Injection with botulinum toxin A in the internal anal sphincter is often used as second-line therapy, although it may give better results and fewer side effects than nitric ...
Balchandra Pooja P Department of Urogynaecology, St James's University Hospital, Level 1, Chancellor Wing, Beckett Street, Leeds, LS97TF, UK, - - 2014
Comprehension of women's perspective and reasons for their choice between intra-detrusor botox (botox) and sacral neuromodulation (SNM) after failed anticholinergic treatment for overactive bladder syndrome (OAB) have not been evaluated and reported in the literature. Our voluntary service evaluation survey aimed to determine reasons behind individual patient choice. All women ...
Hollmig S Tyler ST Department of Dermatology, Stanford University Medical - - 2014
Laser therapies have been Food and Drug Administration approved for temporary nail plate clearance; however, there is minimal evidence of their long-term efficacy. We sought to evaluate the clinical and mycological clearance of toenails treated with 1064-nm neodymium:yttrium-aluminum-garnet laser versus no treatment. This was a randomized, controlled, single-center trial comparing ...
Marmon Shoshana S Hong Kong Dermatology and Laser Centre, Hong Kong, - - 2014
As the demand for diminished procedure-associated downtime continues to increase, nonablative fractional laser resurfacing is becoming a more popular intervention in the progression of photoaging. Patients with pigmented skin and a mild degree of photodamage may be particularly suited for a less intensive laser treatment. In this study, we have ...
Vinay K K Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
Autologous non-cultured outer root sheath hair follicle cell suspension (NCORSHFS) is a recently described novel cellular graft technique for the treatment of stable vitiligo. There is lack of data about various factors determining the repigmentation rate in vitiligo patients undergoing this novel surgical therapy. To study the clinical characteristics and ...
Hees Henrik H Laserklinik - - 2014
Nd:YAG lasers could be a safe and effective treatment modality for onychomycosis, without the side effects of drugs. Long and short-pulsed Nd:YAG lasers were used in this clinical study in a side-comparison manner without removal of onychomycotic nail material before treatment. Big toenails of 10 patients were treated twice in ...
Gupta Vivek V Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, - - 2014
Chronic anal fissure is a benign disorder that is associated with considerable discomfort. Surgical treatment in the form of lateral sphincterotomy has long been regarded as the gold standard of treatment. This study compared the open and closed techniques of lateral sphincterotomy in terms of their postoperative outcomes. A prospective, ...
Lind Marcus M Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Electronic address: - - 2014
Previous studies have shown that biomarkers in blood plasma can predict bleeding complications during anticoagulant treatment as well as thromboembolic events and may improve existing risk stratification schemes in patients on or considered for oral anticoagulant treatment. The aim of this study was to investigate if levels of D-dimer, tissue ...
Kocer Naci N Division of Neuroradiology, Department of Radiology, - - 2014
Object Flow diverter (FD) stents are relatively new and important devices in the treatment of cerebral aneurysms. The Flow Re-Direction Endoluminal Device has been recently released for clinical use. The authors' aim in this paper is to report their initial single-center FRED experience with short-term results. Methods Between February 2012 ...
Radujkovic Aleksandar A Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, - - 2014
We retrospectively analyzed and compared the efficacy and toxicity of azacitidine (AZA) and low-dose cytarabine (LD-Ara-C) in 65 palliative patients with acute myeloid leukemia (AML) showing high bone marrow blast counts (≥30%) before start of treatment. Twenty-seven and 38 patients received AZA and LD-Ara-C, respectively. The median patient age was ...
Ling Tingsheng - - 2014
To investigate the effectiveness of peroral endoscopic myotomy (POEM) surgery in achalasia patients with failure of prior pneumatic dilation. 21 Patients with a history of failed PD were prospectively recruited as the case group, and 30 patients with no history of prior treatment for achalasia were included as the control ...
Abedi Farshad F Center for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, - - 2014
To evaluate 2-year visual acuity outcome of a treat-and-extend protocol of anti-vascular endothelial growth factor treatment in age-related macular degeneration. In this prospective cohort study, 120 age-related macular degeneration patients with choroidal neovascularization received 3 initial monthly ranibizumab or bevacizumab injections; monthly injections were continued until there was no choroidal ...
Kang Duk-Hyun DH Division of Cardiology, Asan Medical Center, College of Medicine, University of Ulsan. Electronic address: - - 2014
This study sought to compare long-term outcomes of early surgery with a conventional treatment strategy in asymptomatic patients with severe mitral regurgitation (MR). The timing of surgery in asymptomatic severe MR remains controversial. From 1996 to 2009, 610 consecutive asymptomatic patients (364 men, age; 50±14 years) with severe degenerative MR ...
Distefano Gail G Royal Surrey Count Hospital, Guildford, GU2 - - 2014
Purpose: To ascertain the progress being made towards the implementation of SABR treatment in the UK, to obtain details of current practice in centres with an active treatment programme and to assess projected future provision. Methods and Materials: In August 2012, an on-line questionnaire was sent to all 65 UK ...
Caffrey Aisling R AR Veterans Affairs Medical Center, Infectious Diseases Research Program, Providence, Rhode Island; University of Rhode Island, College of Pharmacy, Kingston, Rhode - - 2014
The treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is exceedingly complicated, which is concerning because of the high mortality rate associated with the infection. Identification of independent predictors of clinical success can optimize patient care by assisting clinicians in treatment decisions. Our goal was to identify independent predictors of clinical ...
Virga Vittorio V Division of Cardiology, Clinical and Experimental Department of Medicine, University of Messina, Messina, - - 2014
The aim of this prospective registry was to evaluate the safety and efficacy at 2-year follow-up of the use of drug-eluting balloons (DEBs) for the treatment of superficial femoral artery (SFA) in-stent restenosis (ISR). The use of DEBs for the treatment of SFA ISR is associated with a satisfactory primary ...
Sohrabi Bahram B Department of Cardiology, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
This study sought to evaluate the outcomes of endovascular treatment with covered versus bare Cheatham-platinum stents (NuMed, Hopkinton, New York) in coarctation of aorta (CoA) patients. Covered stenting has been newly recognized as a useful therapeutic method for patients with native CoA, but there has been no study comparing the ...
< 1 2 3 4 5 6 7 8 9 10 11 >