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Franeková Janka - - 2014
Abstract Background: Galectin-3 is an emerging biomarker of heart failure and of myocardial fibrosis risk. Monitoring of galectin-3 is essential during treatment with galectin-3 inhibitors. The aim of our study was to assess long-term biological variability in a specific group of unhealthy subjects. Methods: The biological variability of galectin-3 was ...
Zhao Jialiang J Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1, Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China, - - 2014
To evaluate the efficacy and safety of monthly ranibizumab 0.5 mg in Chinese patients with subfoveal choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration (nAMD). A 12-month open-label single-arm multicenter phase III study that included treatment-naïve (study eye) patients with primary/recurrent subfoveal CNV secondary to AMD. Patients (N = 114) aged ≥50 years ...
Richardson Monica L ML Stanford University School of Medicine, Stanford, - - 2014
To determine whether conservative or surgical therapy is more cost effective for the initial treatment of stress urinary incontinence. We created a decision tree model to compare costs and cost effectiveness of three strategies for the initial treatment of SUI: a) continence pessary b) pelvic floor muscle therapy c) mid-urethral ...
Murina Filippo F Outpatient Department of Vulvar Disease, V. Buzzi Hospital-ICP-University of Milan, Milan, - - 2014
To compare the efficacy of the short-term application of clobetasol propionate 0.05% (CLB) and mometasone furoate 0.05% (MMF) in the treatment of vulvar lichen sclerosus (VLS). This study was a retrospective review of 96 women who were diagnosed with lichen sclerosus with a follow-up of at least 1 year. Of ...
Yamamoto Erica E Pediatric Gastroenterology Division, Escola Paulista de Medicina, Universidade Federal de São - - 2014
AIM:: to estimate the rate of clinical and endoscopic relapse after initial treatment of erosive peptic esophagitis in children and adolescents. 24 patients (2.1 to 16.4 year-old, mean ± SD: 9.9 ± 3.1; M:F 3) with healed endoscopic erosive esophagitis and without GERD-predisposing conditions were followed up for 4 to 32.9 months (mean 20.8 yrs ± 10.6). ...
Tremaine Anne Marie AM *Department of Dermatology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; †Goldman, Butterwick, Fitzpatrick, Groff & Fabi: Cosmetic Laser Dermatology, San Diego, - - 2014
Despite being the gold standard for lower extremity reticular vein treatment, few studies have yet evaluated foam sclerotherapy for hand veins. This retrospective study evaluates the safety and efficacy of foam sclerotherapy for reticular veins of the dorsal hands. A telephone-based questionnaire was used for patient self-assessment of overall improvement, ...
Yun Woo Jin WJ *All the authors are affiliated with the Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Recently, intense pulsed light (IPL) and low-fluence Q-switched neodymium-doped yttrium aluminum (LF-QS-Nd:YAG) laser have been successfully used to treat melasma. To evaluate the effectiveness and safety of combined novel fractionated IPL (IPL-F) with LF-QS-Nd:YAG laser in patients with melasma. Twelve patients underwent 6 treatment sessions of concomitant IPL-F and LF-QS-Nd:YAG ...
Işik Selda S Department of Dermatology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, - - 2014
Anogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH) solution with that of a ...
Chandrashekar Byalakere Shivanna BS Rajiv Gandhi University of Health Sciences, Karnataka, India; Diplomate of National Board, New Delhi, - - 2014
It is reported that patients on oral isotretinoin have greater risk of developing scars and delayed wound healing with invasive procedures. It is recommended that these procedures be resumed 6-12 months after the last dose of oral isotretinoin. To assess and compare the safety and look for delayed wound healing, during ...
Haas Alex Nogueira AN Periodontology Department, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, - - 2014
Properly performed daily mechanical biofilm control is the most important prevention strategy for periodontal diseases. However, proper mechanical biofilm control is not performed effectively by the majority of the population, mainly due to lack of motivation and of manual dexterity. Local biofilm retention factors may aggravate home oral hygiene quality. ...
Zhang Yifei Y Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, - - 2014
We recently demonstrated a beneficial effect of metformin compared with glipizide in type 2 diabetic patients regarding cardiovascular outcomes for 3-year treatment in the SPREAD-DIMCAD study. However, the potential mechanism for the clinical effects remains unclear. Here, we performed a comprehensive lipidomics study to evaluate the different lipid metabolites in ...
Troeltzsch Markus - - 2014
Objective: To investigate the efficacy of conservative dental treatment (occlusal splint and pharmacologic therapy) and invasive therapy (prosthetic restorations) in the treatment of tension-type headache (TTH). Method and Materials: The study sample was composed of 70 patients who presented with symptomatic TTH and were assigned to three treatment groups according ...
Sanchis Jose María - - 2014
Objective: A study was designed to measure of the incidence of bisphosphonate-related osteonecrosis of the jaws (BRONJ) following tooth extraction in patients receiving or who have received intravenous bisphosphonates (Zometa, zoledronic acid). Method and Materials: A prospective cohort study was made of 36 patients subjected to 62 tooth extractions. All ...
Dungan Kathleen M KM The Ohio State University, Columbus, OH, USA. Electronic address: - - 2014
Dulaglutide and liraglutide, both glucagon-like peptide-1 (GLP-1) receptor agonists, improve glycaemic control and reduce weight in patients with type 2 diabetes. In a head-to-head trial, we compared the safety and efficacy of once-weekly dulaglutide with that of once-daily liraglutide in metformin-treated patients with uncontrolled type 2 diabetes. We did a ...
Sadiq Saghir Ahmed SA Manchester Royal Eye Hospital, Oculoplastics, Orbital and Lacrimal - - 2014
Abstract Background: Botulinum toxin A (BTXA) injection to the levator palpebrae superioris muscle to induce a protective ptosis can adversely cause reduced upgaze due to diffusion of BTXA to the superior rectus muscle. Purpose: To compare the incidence of reduced upgaze in trascutaneous versus transconjunctival administration of BTXA to induce ...
Kinon Bruce J BJ Eli Lilly and Company, Indianapolis, IN, - - 2014
The risk of persistent tardive dyskinesia (TD) was compared in patients with acute psychosis or agitation aged 55 years or older who were treated with olanzapine (OLZ) or conventional antipsychotic (CNV) drug therapy. Patients without TD were randomized to treatment with OLZ (2.5-20 mg/d; n = 150) or CNV (dosed ...
Shin Joo Young JY *Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea; and †Sensory Organs Institute, Medical Research Center, Seoul National University, Seoul, South - - 2014
To evaluate the visual outcome of optical coherence tomography-based ranibizumab monotherapy in Korean patients with retinal angiomatous proliferation and identify prognostic factors of visual outcome. A prospective single-arm clinical study of 31 retinal angiomatous proliferation patients who underwent 3 consecutive monthly intravitreal ranibizumab injections was conducted. Additional treatment was given ...
Chiu Chun-Chieh CC Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University, - - 2014
To determine the probability of spontaneous disc regression among each type of lumbar herniated disc, using a systematic review. Medline, Cochrane Library, CINAHL, and Web of Science were searched using key words for relevant original articles published before March 2014. Articles were limited to those published in English and human ...
Ozcan Altan A AA *Faculty of Medicine, Department of Ophthalmology, Çukurova University, Adana, Turkey; and †Department of Ophthalmology, Adana Numune Training and Research Hospital, Adana, - - 2014
To report our experience in the treatment of intraepithelial neoplasia of the conjunctiva using topical bevacizumab. Ten eyes of 10 patients with conjunctival neoplasia received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatment, excisional biopsy was performed. The mean age of ...
Caúla André Luis AL Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, - - 2014
To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control ...
John Anitha S AS Division of Cardiology, Children's National Medical Center, George Washington University School of Medicine, Washington, DC; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address: - - 2014
Patients with protein-losing enteropathy (PLE) following the Fontan operation have a reported 50% mortality at 5 years after diagnosis. The aim of this study was to review outcomes in patients with PLE following the Fontan operation. From 1992 to 2010, 42 patients (55% male) with PLE following the Fontan operation ...
Wiedel Anna-Paulina AP a Research Fellow, Department of Oral and Maxillofacial Surgery, Skane University Hospital, Malmö, - - 2014
Abstract Objective: To compare and evaluate the stability of correction of anterior crossbite in the mixed dentition by fixed or removable appliance therapy. Material and Methods: The subjects were 64 consecutive patients who met the following inclusion criteria: early to late mixed dentition, anterior crossbite affecting one or more incisors, ...
Akl Elie A EA Department of Internal Medicine, American University of Beirut, Riad El Solh St, Beirut, - - 2014
Cancer increases the risk of thromboembolic events in patients including those receiving anticoagulation treatments. To compare the efficacy and safety of low molecular weight heparin (LMWH) and oral anticoagulants for the long-term treatment of venous thromboembolism (VTE) in patients with cancer. We conducted a comprehensive search for studies of anticoagulation ...
Schneider David F DF Section of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, - - 2014
Persistent or recurrent hyperthyroidism after treatment with radioactive iodine (RAI) is common and many patiedlxnts require either additional doses or surgery before they are cured. The purpose of this study was to identify patterns and predictors of failure of RAI in patients with hyperthyroidism. We conducted a retrospective review of ...
Nair Rueben R Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, 676 N St Clair Street, Suite 1350, Chicago, IL, 60611, - - 2014
Although lumbar discectomy for treatment of lumbar disc herniation in the general population generally improves patients' pain, function, and validated outcomes scores, results of treatment in elite athletes may differ because of the unique performance demands required of competitive athletes. We performed a systematic review to answer the following questions: ...
Samson S L SL Medical Director, The Pituitary Center, Baylor St. Luke's Medical Center, Division of Endocrinology, Department of Medicine, Baylor College of Medicine, - - 2014
Cushing's disease is a rare condition of chronic hypercortisolism caused by an adrenocorticotropic hormone-secreting pituitary adenoma and associated with debilitating complications and excess mortality. Transsphenoidal adenomectomy is generally first-line treatment but is contraindicated in some patients and associated with significant post-surgical recurrence. While there are few data to support long-term ...
Li Chunbo C Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Feng Lin Road No. 180, XuHui District, Shanghai, 200032, People's Republic of - - 2014
Spinal epidural fibrosis and adhesion are implicated as one of the key factors of failed back surgery syndrome, which may cause dura mater compression or peridural tethering, resulting in persistent backache and leg pain. Various materials or drugs have been used to inhibit formation of epidural fibrosis and reduce the ...
Kjaergaard Krista Dybtved KD Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: - - 2014
Glomerular filtration rate (GFR) declines during long-term dialysis treatment. In peritoneal dialysis, blockade of the renin-angiotensin-aldosterone system reduces GFR decline. Observational studies suggest that similar treatment may preserve kidney function in hemodialysis (HD). A multicenter, randomized, placebo-controlled, double-blinded trial, with 1-year follow-up. Adult HD patients with urine output >300mL/24h, HD ...
Sun Jingmin J Department of Interventional Radiology and Vascular Surgery, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, - - 2014
To evaluate the safety and clinical efficacy of warfarin anticoagulation following balloon dilation alone for the treatment of Budd-Chiari syndrome (BCS) complicated by old inferior vena cava (IVC) thrombosis. From January 2008 to November 2013, 19 BCS patients complicated with old IVC thrombosis were treated with balloon dilation followed by ...
Li Bing B Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong, China; Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, - - 2014
The study was designed to evaluate the effectiveness of the combination of chemonucleolysis and psoas compartment block (PCB) for the treatment of lumbar disc herniations (LDHs) and to explore the role of PCB in managing postoperative pain of collagenase injection. Two groups of patients (N = 192) were treated in different ways, ...
Lorente J J Servicio de Otorrinolaringología (ORL), Hospital Vall - - 2014
Objective: We aimed to evaluate the clinical efficacy of ciprofloxacin plus fluocinolone acetonide (antibiotic plus corticosteroid) ear drops compared to ciprofloxacin (antibiotic) ear drops in diffuse otitis externa. Methods: This was a multicentre, randomised, parallel-group, double-blind study involving 590 patients of both sexes aged 7 years or older. Results: The rate ...
Faber Kenneth Dale KD University of Southern California, Urology , 1441 Eastlake Ave , Suite 7416 , Los Angeles, California, United States , 90089 , (323) 865-3700 ; - - 2014
Introduction and Objective: To evaluate the safety and efficacy of a novel robotic tissue ablation system (PROCEPT AquablationTM System, PAS), in performing prostate ablation in a survival canine model. Methods: This novel technology uses a high-velocity saline stream delivered that aims to selectively ablates prostatic glandular tissue while sparing collagenous ...
Lee Gun Woo GW Department of Orthopaedic Surgery, Armed Forces Yangju Hospital, Yongam-ri, 49-1, Eunhyeon-myeon, Yangju-si, 482-863, Republic of Korea. Electronic address: - - 2014
Generalized joint laxity (GJL) has been associated with spine-related disorders such as lower back pain, accelerated disc degeneration, and recurrence after discectomy surgery for primary lumbar disc herniation (p-LDH). GJL might be a causative factor of p-LDH, but this relationship is poorly understood. In addition, the impact of GJL on ...
Kwon Hyunwook H Division of Vascular Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, - - 2014
Although dysfunctional radiocephalic arteriovenous fistulas (RCAVFs) are typically treated surgically, the endovascular approach is also considered suitable. The aim of this retrospective study was to compare the cumulative patency rates following surgical and endovascular salvaging of dysfunctional RCAVFs, and to evaluate whether the maturity of vascular access sites at the ...
Sun Jingcheng J Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin Heping District, Anshan Road 154, Tianjin 300052, PR - - 2014
We describe two surgical strategies for treating thoracic spinal stenosis (TSS) with ossification of the ligamentum flavum (OLF) and dural ossification (DO), and discuss their postoperative efficacy. From January 2004 to June 2008, 147 patients underwent TSS surgery. Thirty three of those with intraoperative evidence of OLF and DO were ...
Pericas Juan M JM Infectious Diseases Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, - - 2014
The aim of this study was to assess changes in antibiotic resistance, epidemiology, and outcome among patients with Enterococcus faecalis infective endocarditis (EFIE) and to compare the efficacy and safety of the combination of ampicillin and gentamicin (A+G) with that of ampicillin plus ceftriaxone (A+C). The study was a retrospective ...
Ito Tomoyasu T Department of Gastroenterology, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-ku, Tokyo 177-8521, Japan. - - 2014
To compare the pharmacokinetics of RF ablation with chemolipiodolization using cisplatin (CDDP) powder and miriplatin (MPT) in a porcine liver. Twelve pigs were divided equally into four groups. After each CDDP powder-lipiodol suspension (n=6;: groups A and B) or MPT-lipiodol suspension (n=6;:groups C and D) was injected into the lateral ...
Dijkstra Siebren S Department of Urology, Radboud University Medical Center, Nijmegen, the - - 2014
To monitor systemic disease activity, the potential of circulating tumor cells (CTCs) bears great promise. As surrogate for CTCs we measured KLK3, PCA3, and TMPRSS2-ERG messenger RNA (mRNA) in the peripheral blood mononuclear cell (PBMC) fraction from a castration-resistant prostate cancer (CRPC) patient cohort and three control groups. Moreover, biomarker ...
Hong Sang Duk SD Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, - - 2014
Immunosuppression after liver transplantation (LT) increases complications from infection. The usefulness of sinonasal evaluation before LT has not been fully evaluated. The aim of this study was to determine the usefulness of routine sinonasal evaluation before LT and pre-transplant treatment of sinusitis. The clinical records of 982 adult patients (age ...
Kashii Masafumi M Department of Orthopedic Surgery, Faculty of Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan, - - 2014
Surgical treatment of osteoporotic vertebral collapse (OVC) with neurological deficits presents significant clinical challenges because some patients have fragile bones and often have medical comorbidities, which affect the severity of osteoporosis. We hypothesized that clinical results of surgery in these patients depend on the extent of medical comorbidities that induce ...
Deniz Uzuner F F Department of Orthodontics, Faculty of Dentistry, Gazi University, Biskek Cd. (8.Cd.) 82.Sk. No:4, 06510, Emek, Ankara, Turkey, - - 2014
The aim of this study was to compare the skeletal and dental effects of the EVAA appliance with those of an activator appliance in growing children with skeletal Class II anomalies. A total of 34 subjects with Class II anomalies were recruited for this study. They were divided into three groups: the EVAA ...
Lee Yoon Se YS Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Vocal fold paralysis (VFP) is a frequent complication of surgery of mediastinal structures. This study evaluated the characteristics and short-term treatment outcomes of injection laryngoplasty for unilateral VFP (UVFP) induced by mediastinal lesions. The enrolled patients (n = 60) underwent injection laryngoplasty once because of UVFP and were divided into two groups ...
Lévy-Sitbon Célia C Service de Dermatologie, Hôpital Robert Debré, CHU de Reims, Reims, - - 2014
Background: Recently, a consensus Bullous Pemphigoid Disease Area Index (BPDAI) was proposed to measure therapeutic outcomes in bullous pemphigoid (BP). Objective: To compare BPDAI with other clinical parameters of disease activity at baseline and to describe the variations of BPDAI during the initial phase of treatment. Methods: Thirty BP patients ...
Patel Vikas V - - 2014
Interspinous spacers are a minimally invasive surgical alternative for patients with lumbar spinal stenosis (LSS) unresponsive to conservative care. The purpose of this prospective, multicenter randomized, controlled trial was to compare 2-year clinical outcomes in patients with moderate LSS treated with the Superion(R) (Experimental) or the X-Stop(R), a FDA-approved interspinous ...
Jara-Palomares Luis L Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocío, CIBERES, Seville, - - 2014
Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute symptomatic VTE. Open follow-up study of a cohort of ...
Morasiewicz P P Wrocław Medical University, Department and Clinic of Orthopaedic and Traumatologic Surgery, ul. Borowska 213, 50556 Wrocław, Poland. Electronic address: - - 2014
One of the many uses of the Ilizarov fixator is for torsional deformities correction. Rotational and translational bone displacement related to torsional deformities correction includes the additional tension stresses, which affect the biology of the regenerated bone. Understanding the clinical factors will assist in designing the optimal treatment strategy, thus ...
Jianhui Zhao Z *Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi; and †Department of Plastic Surgery, Chinese PLA General Hospital, Beijing, - - 2014
Progressive facial hemiatrophy, also called Parry-Romberg syndrome (PRS), is characterized by slowly progressive atrophy of one side of the face and primarily involves the subcutaneous tissue and fat. The restoration of facial contour and symmetry in patients affected by PRS still remains a challenge clinically. Fat graft is a promising ...
Lu Cong C aDivision of Cardiology, Chengdu First People's Hospital, Chengdu, China bDepartment of Evidence-Based Medicine Center & Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, - - 2014
Immunosuppressive treatment for myocarditis is controversial. Several small-scale randomized controlled trials (RCTs) reported inconsistent outcomes for patients with myocarditis. We searched on the Medline, Embase, and Cochrane databases for articles in English language between January 1966 and May 2013, as well as on the China National Knowledge Internet (CNKI, 1979 ...
Kappler Matthias M Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: - - 2014
Patient dependent parameters to predict the long-term success of early eradication treatment of Pseudomonas aeruginosa have not yet been defined. For this purpose we assessed serum antibodies against P. aeruginosa in CF patients after early eradication treatment. Retrospective analyses of all consecutive patients with first P. aeruginosa detection 2005 to ...
Emr Bryanna M BM 1Department of Surgery, SUNY Upstate Medical University, Syracuse NY 2Department of Biology, SUNY Cortland, Cortland NY 3Department of Pediatrics, University of Rochester, Rochester NY 4Department of Biomedical Engineering, University of Rochester, Rochester - - 2014
Acute Respiratory Distress Syndrome (ARDS) is a common cause of organ failure with an associated mortality rate of 40%. The initiating event is disruption of alveolar-capillary interface causing leakage of edema into alveoli. Hypothesis: Electroporation mediated gene delivery of epithelial sodium channel (ENaC) and Na,K-ATPase into alveolar cells would improve ...
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