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Jia Renbing R Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of - - 2014
IMPORTANCE Low-flow orbital or periorbital venous malformation (OVM) is the most common periorbital vascular lesion that may produce an appearance defect, visual dysfunction, internal hemorrhage, and thrombosis. Intralesional injection of pingyangmycin as a minimally invasive, gentle intervention may have better outcomes in treating low-flow OVMs compared with other currently used ...
Kim Benjamin J BJ Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, 51 N 39(th) St, Philadelphia, PA, 19104. Electronic address: - - 2014
To evaluate transient, large visual acuity (VA) decreases, termed sporadic vision loss, during anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration (AMD). Cohort within a randomized clinical trial. Setting: Comparison of AMD Treatments Trials (CATT). Study Population: 1185 CATT patients. Main Outcome Measures: incidence of sporadic vision loss ...
Mantel Irmela I Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, - - 2014
The purpose of this study was to clinically validate an individually planned treatment regimen for neovascular age-related macular degeneration (nAMD), termed, observe and plan. This regimen was based on the predictability of an individual's need for retreatment and aimed to reduce the clinical burden, while obtaining good functional results. This ...
Hernández-Durán Silvia S Neurosurgical Service, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Wang 745, Boston, MA, USA, - - 2014
The purpose of this study was to present a meta-analysis on the safety and efficacy of different endovascular modalities when treating vertebral artery dissections, since ideal treatment remains controversial. We performed a meta-analysis of 39 retrospective studies involving different treatment modalities for vertebral artery dissections in adults and obtained weighted ...
Farr Jack J OrthoIndy, Indianapolis, Indiana, - - 2014
BACKGROUND:Biological repair of cartilage lesions remains a significant clinical challenge because of the lack of natural regeneration and limited treatment options. HYPOTHESIS:Treatment of articular cartilage lesions in the knee with particulated juvenile articular cartilage (PJAC) will result in an improvement in patient symptoms of pain and function and magnetic resonance ...
Luk Lauren L Oregon Sinus Center, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, - - 2014
Potassium-titanyl-phosphate (KTP) laser photocoagulation is commonly used for treatment of hereditary hemorrhagic telangiectasia-related epistaxis (HHT-RE). Electrosurgical plasma coagulation (EPC), also known as coblation, has not been rigorously evaluated for HHT-RE. Patients seeking treatment for HHT-RE between September 2010 and September 2012 were prospectively randomized (1:1) to KTP or EPC in ...
Durmus Basak B Department of Pediatric Dentistry, Faculty of Dentistry, Marmara University , Istanbul, Turkey - - 2014
Abstract Objective: The purpose of this study was to assess whether the diode laser (DL) pulpotomy method is a suitable alternative to formocresol (FC) and ferric sulphate (FS) pulpotomies in human primary teeth. Background data: Pulpotomy is the amputation of infected coronal pulp to maintain radicular pulp vitality and function. ...
Awad Samir S SS Baylor College of Medicine, Section of Surgical Critical Care, Houston, - - 2014
Background. Ceftobiprole, the active moiety of ceftobiprole medocaril, is a novel broad-spectrum cephalosporin, with bactericidal activity against a wide range of Gram-positive bacteria, including Staphylococcus aureus (including methicillin-resistant strains) and penicillin- and ceftriaxone-resistant pneumococci, and Gram-negative bacteria, including Enterobacteriaceae and Pseudomonas aeruginosa. Methods. A double-blind, randomized, multicenter study of 781 patients with ...
Hayashi Norio N Kansai Rosai Hospital, Hyogo, - - 2014
In a Japanese Phase II study, the hepatitis C virus NS3/4A protease inhibitor simeprevir demonstrated potent antiviral activity and significantly improved sustained virologic response rates when added to peginterferon α-2a/ribavirin in treatment-naïve patients infected with hepatitis C virus genotype 1. CONCERTO-1 was a Phase III, randomized, double-blind, placebo-controlled trial. Treatment-naïve ...
Andujar-Plata P P Endocrinology Division, Complejo Hospitalario Universitario de Santiago de Compostela, Universidad de Santiago de Compostela, Travesía da Choupana s/n, 15706, Santiago de Compostela, La Coruña, - - 2014
The treatment of adults with GH deficiency (GHD) with human recombinant growth hormone has interindividual variability and several factors influence it. The aims of this study were : 1-to analyze the GH receptor (GHR) genotype in terms of exon 3 deletion GHR (d3-GHR) in adults with GHD; 2-to assess the ...
Schüttler Karl F KF Department of Orthopedics and Rheumatology, University Hospital Marburg, Baldingerstrasse, 35043, Marburg, - - 2014
Meniscal injury resulting in segmental loss of meniscal tissue is a major risk factor for the development of osteoarthritis. Tissue engineering strategies have provided scaffolds for meniscal regeneration in order to establish a treatment option for patients with limited opportunities for meniscal reconstruction. The purpose of this study was to ...
Gögenur Ismail I Department of Surgery, University of Copenhagen, Herlev Hospital, - - 2014
The aim was to examine the effect of perioperative melatonin treatment on clinical cardiac morbidity and markers of myocardial ischemia in patients undergoing elective surgery for abdominal aortic aneurism. Reperfusion injury results in increased cardiac morbidity in patients undergoing surgery for abdominal aortic aneurisms (AAA). A randomized, placebo controlled, clinical ...
Saris Daniel D University Medical Center Utrecht, Utrecht, the - - 2014
BACKGROUND:Randomized controlled trials studying the efficacy and safety of matrix-applied characterized autologous cultured chondrocytes (MACI) versus microfracture (MFX) for treating cartilage defects are limited. PURPOSE:To compare the clinical efficacy and safety of MACI versus MFX in the treatment of patients with symptomatic cartilage defects of the knee. STUDY DESIGN:Randomized controlled ...
Boons Christel Clm - - 2014
The antitumor drug nilotinib has a large inter- and intra individual variability in pharmacokinetics. Adherence to treatment may substantially influence plasma levels and has been recognized as the most important determinant of treatment failure in chronic myeloid leukemia (CML). A better understanding of the various factors contributing to the efficacy ...
Brinjikji Waleed W Department of Radiology, Mayo Clinic, Rochester, Minnesota, - - 2014
Expansion of the endovascular and surgical workforce in the USA might lead to carotid revascularization procedures being carried out at low volume centers. To evaluate trends in the treatment of carotid stenosis at high volume centers in the USA and compare outcomes by hospital volume. Using the Nationwide Inpatient Sample, ...
O'Neill Kevin R KR Washington University, Department of Orthopaedics, St. Louis, Missouri, - - 2014
Study Design. Retrospective review of prospective database.Objective. To investigate the long-term results following extension of previous long spine fusions to the sacrum.Summary of Background Data. Long spine fusions not involving the sacrum may be complicated by distal degeneration and require subsequent extension to the sacrum. The clinical and radiographic outcomes ...
Lad Shivanand P SP 1Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA. 2Department of Neurosurgery, University of Louisville, Louisville, KY, USA 3Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
Study Design. Retrospective analysis of a population-based insurance claims data setObjective. To evaluate the use of spinal cord stimulation (SCS) and lumbar reoperation for the treatment of failed back surgery syndrome (FBSS), and examine their associated complications and healthcare costs.Summary of Background Data. FBSS is a major source of chronic ...
Kim Hae Jin - - 2014
The purpose of this study was to compare surgical outcomes of unilateral lateral rectus recession (ULR) and unilateral recess-resect (RR) for intermittent exotropia of 20-25 prism diopters (PD). In this retrospective study, ULR was performed on 82 patients and RR on 98 patients for the treatment of intermittent exotropia of ...
Shive Matthew S MS Piramal Healthcare (Canada) Ltd. Electronic address: - - 2014
Intra-lesional bony overgrowth (BO) identified during or following cartilage repair treatment is being frequently described through subjective reports focusing primarily on incidence. Our objective was to quantify the exact volume of intra-lesional BO at 12 months post-cartilage repair treatment, to determine if a correlation exists between the extent of BO ...
Alarcon Ivette I Dermatology Department, Melanoma Unit, Hospital Clinic of Barcelona; Institut de Recerca Biomédica August Pi i Sunyer - - 2014
Imiquimod has been used for treating lentigo maligna (LM) in selected cases when surgery is not an appropriate option because of functional or aesthetic impairment. Reflectance confocal microscopy (RCM) is a noninvasive method that has not been validated for monitoring the treatment of LM with imiquimod. We sought to evaluate ...
Skadorwa Tymon T Department of Pediatric Neurosurgery, Bogdanowicz Memorial Hospital for Children, Warsaw, - - 2014
Background: Epidural hematoma (EDH) is the most common form of intracranial bleeding following head trauma in pediatric patients. It may develop into a life-threatening pathology, requiring an immediate neurosurgical intervention. However, due to an increasing number of posttrauma CT scans most pediatric EDH patients can be treated conservatively, because of ...
Francis Joshua R JR Western Australia Tuberculosis Control Program, Perth, WA, Australia. - - 2014
OBJECTIVE To describe the epidemiology, clinical features, health care resource use, treatment and outcomes of multidrug-resistant tuberculosis (MDR-TB) cases diagnosed in Western Australia, compared with matched controls with drug-susceptible TB. Retrospective case-control study of all MDR-TB cases notified in WA between 1 January 1998 and 31 December 2012, compared with matched controls. Cases ...
Fujita Takeo T Division of Esophageal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan, - - 2014
Postoperative chylothorax sometimes follows thoracic esophagectomy for esophageal cancer. The effectiveness of octreotide treatment for it and factors that predict its response are unclear. This study aimed to evaluate the efficacy of octreotide for treating postoperative chylothorax following thoracic esophagectomy for esophageal cancer and factors that might predict successful treatment ...
Kuhlen M M Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, Medical Faculty, Heinrich-Heine-University, - - 2014
Osteonecroses (ON) are a serious problem after anti-leukaemic treatment in childhood and critically depend on treatment intensity. We analysed ON incidence, risk factors and outcome in patients (pts) from our institution treated according to the CoALL 07-03 trial.Between 01.09.2003 and 31.12.2009, 124 children aged 1-18 years were treated, 22 pts ...
Dieterich Douglas D Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, - - 2014
Faldaprevir is an investigational hepatitis C virus (HCV) NS3/4A protease inhibitor which, when administered for 24 weeks in combination with pegylated-interferon α-2a and ribavirin (PegIFN/RBV) in treatment-naïve patients in a prior study, achieved sustained virologic response (SVR) rates of 72-84%. The current randomized, open-label, parallel-group study compared the efficacy and ...
Cho Jaeho J Department of Orthopedic Surgery, Inje University, Seoul Paik Hospital, Seoul, - - 2014
This study compared the operative outcome between retinaculum repair with and without fibular groove deepening for the treatment of recurrent traumatic peroneal tendon dislocation in young, active patients. A consecutive series of 29 patients who underwent operative treatment of recurrent peroneal tendon dislocation were evaluated. Thirteen patients were treated by ...
Frazier-Mironer Aline A Fédération de rhumatologie, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, - - 2014
To compare retention rates of adalimumab, etanercept and infliximab as first-line biotherapy in rheumatoid arthritis (RA), to determine causes of discontinuation, retention-associated factors, and retention rates of possible second-line TNF-α inhibitors (TNFi). In this retrolective, multicentric study, medical charts of RA patients starting TNFi between March 2005 and April 2009 ...
Hogendoorn Wouter W Section of Vascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn; Section of Vascular Surgery, Department of Surgery, University Medical Center, Utrecht, The - - 2014
Open revascularization (OR) has been the treatment of choice for chronic mesenteric ischemia (CMI) for many years, but endovascular revascularization (EV) has been increasingly used with good short-term results. In this study, we evaluated the comparative effectiveness and cost-effectiveness of EV and OR in patients with CMI refractory to conservative ...
Arslan Mehmet M Urology Department, Meram Medical Faculty, Necmettin Erbakan University, Meram, Konya, - - 2014
Minimally invasive methods, especially the novel techniques, gain more and more popularity in benign prostate hyperplasia (BPH) treatment. Transurethral ethanol injection is one of these novel methods as it is easy to apply for BPH treatment and quite successful. The present study evaluates the results of a single-year transurethral ethanol ...
Considine S S Mater Misericordiae University Hospital, Dublin, Ireland, - - 2014
In recent years, the enzyme collagenase has been developed for the percutaneous treatment of Dupuytren's contracture, allowing management of the condition as an outpatient. We present early results on the treatment of Dupuytren's contracture using injectable collagenase. Patients awaiting Fasciectomy for Dupuytren's Contracture were selected for enrolment. Contracture cords were then ...
Eshraghi Bahram B Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran - - - 2014
PurposeTo assess the success rate of pushed stent intubation in children with complex congenital nasolacrimal duct obstruction (CNLDO).MethodsThis prospective study was performed in a single academic center. Forty-four eyes with complex CNLDO were treated with pushed stent intubation. Outcome measures included clinical signs plus a parental history of residual symptoms ...
Monteiro M R F P MR Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, - - 2014
To compare the anaesthetic efficacy of the inferior alveolar nerve block (IANB) with 1.8 mL of 2% lidocaine (LI) to a buccal infiltration (BI) with 1.8 mL of 4% articaine (AR), both with 1:100,000 epinephrine, in patients with symptomatic irreversible pulpits in a randomized controlled trial. Volunteers presenting at the ...
Sawada Tomoko T Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520-2192, Japan, - - 2014
To evaluate the efficacy of bimonthly intravitreal injections of ranibizumab for age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) in a pilot study. This study was a prospective, interventional case series. Thirty eyes of 30 patients received prospectively at least three bimonthly intravitreal injections of ranibizumab (0.5 mg/0.05 ml) without loading ...
Lee Yun-Hsuan YH *Faculty of Medicine ¶Institute of Clinical Medicine **Institute of Pharmacology, National Yang-Ming University School of Medicine Departments of ‡Medicine ∥Surgery #Radiology, Taipei Veterans General Hospital †Department of Medicine, Yuanshan Branch of Taipei Veterans General Hospital, Taipei, Taiwan §Department of Biostatistics, UCLA, Los Angeles, - - 2014
Radiofrequency ablation (RFA) and surgical resection (SR) are effective therapies for hepatocellular carcinoma (HCC) within the Milan criteria. We aimed to compare the treatment efficacy according to the liver functional reserve using propensity score analysis. There were 330 and 369 HCC patients within the Milan criteria undergoing SR and RFA, ...
Bendtsen Flemming F Gastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, Denmark. Electronic address: - - 2014
Two randomized controlled studies have evaluated the effect of recombinant Factor VIIa (rFVIIa) on variceal bleeding in cirrhosis without showing significant benefit. The aim of the present study was to perform a meta-analysis of the two trials on individual patient data with special focus on high risk patients. The primary ...
Suman Devi S DS Center for Vector Biology, Rutgers University, 180 Jones Ave., New Brunswick, NJ, 08901-8536 USA. Electronic address: - - 2014
Autodissemination of insecticides is a novel strategy for mosquito management. We tested if contaminated Aedes albopictus (Skuse) mosquitoes from a small area treated with commercial formulations (79 gm a.i. pyriproxyfen/ha) using conventional techniques, would disseminate pyriproxyfen over a wider area. Pyriproxyfen showed LC50=0.012 ppb for Ae. albopictus. Direct treatment and ...
Levinger Eliya E Department of Ophthalmology, Tel-Aviv Medical Center, Tel-Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, - - 2014
To determine the safety and efficacy of topical 0.03 % tacrolimus ointment treatment for subepithelial corneal infiltrates (SEIs). This prospective non-controlled interventional case series included patients with SEIs who had been previously treated with topical corticosteroids with either no improvement or the medication being withdrawn due to associated intraocular pressure (IOP) ...
Giannini S S I Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna University, Via Giulio Cesare Pupilli 1, 40136, Bologna, Italy, - - 2014
Bipolar fresh osteochondral allografts (BFOA) recently became a fascinating option for articular cartilage replacement, in particular in those young patients non-suitable for traditional replacement because of age. While the use of osteochondral allografts for the treatment of focal osteochondral lesions in the knee is well established, their use in the ...
Zhengyong Yuan Y Department of Urology, Dujiangyan Medical Center , Dujiangyan , PR - - 2014
Abstract Objective.The aim of this study was to investigate the efficacy of bladder training before removing the indwelling urinary catheter in patients with acute urinary retention (AUR) associated with benign prostatic hyperplasia (BPH). Material and methods. In total, 845 consecutive patients with their first episode of spontaneous AUR associated with ...
Tirosh Amit A Institute of Endocrinology, Rabin Medical Centre, Beilinson Campus, 49100, Petah Tiqva, - - 2014
Men with prolactin-secreting tumors usually harbor macroadenomas. The degree of pituitary dysfunction may vary among different adenoma size subgroups, as is recovery after treatment. Our study purpose was to characterize hypopituitarism and recovery after treatment in men with macroprolactinomas. A retrospective study, including a consecutive group of 81 men with ...
Dréno Brigitte B Dept of Dermato-Cancerology, University of Nantes, Place Alexis Ricordeau, 44093, Nantes, - - 2014
Background: The efficacy and safety of clindamycin phosphate 1.2%/tretinoin 0.025% (Clin-RA) were evaluated in three 12-week randomised studies. Objectives: To perform a pooled analysis of data from these studies to evaluate its efficacy and safety in a larger population, in adolescents and in different acne severities. Materials & Methods: 4550 ...
Oehme David D The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, - - 2014
Object Following microdiscectomy, discs generally fail to undergo spontaneous regeneration and patients may experience chronic low-back pain and recurrent disc prolapse. In published studies, formulations of mesenchymal progenitor cells combined with pentosan polysulfate (MPCs+PPS) have been shown to regenerate disc tissue in animal models, suggesting that this approach may provide ...
Slaghekke F F Division of Fetal Medicine, Department of Obstetrics, Leiden University Medical Center, The - - 2014
Our aim was to evaluate the effect of laser treatment for antenatally detected twin anemia-polycythemia sequence (TAPS) compared to non-laser treatment options. All monochorionic twin pregnancies with TAPS managed between 2005 and 2013 in two European fetal therapy centers were evaluated. Outcome of TAPS cases treated primarily with laser surgery ...
Leibowitz Jason M JM Department of Otolaryngology-Head and Neck Surgery, University of Miami-Miller School of Medicine, Miami, Florida, - - 2014
To compare the different modalities for treatment of Zenker's diverticulum and the associated clinical outcomes. Case series with chart review. Tertiary care hospital. Between 1995 and 2011, 164 patients underwent surgery for Zenker's diverticulum (stapler, n = 69; laser, n = 68; open, n = 27). Patient sociodemographics, medical comorbidities, ...
Schulz Matthias M Departments of Pediatric Neurosurgery - - 2014
Object Neonatal intraventricular hemorrhage (IVH) may evolve into posthemorrhagic hydrocephalus and cause neurodevelopmental impairment. In this study, an endoscopic surgical approach directed toward the removal of intraventricular hematoma was evaluated for its safety and efficacy. Methods Between August 2010 and December 2012 (29 months), 19 neonates with posthemorrhagic hydrocephalus underwent ...
Davaine Jean-Michel JM CHU de Nantes, l'Institut du thorax, Service de Chirurgie Vasculaire, Nantes, F-44000 France; Inserm UMR 957, Nantes, - - 2014
The one year results of the prospective register STELLA suggested that primary stenting long femoro-popliteal (FP) lesions (≥ 15-cm) was a sure and effective treatment. However, the long-term results of this technique remain unknown. STELLA is a prospective monocentric register of patients treated for FP lesions ≥15-cm (TASC C and ...
Parlak Erkan E Department of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, - - 2014
The outcome of endoscopic treatment for the management of surgical end-to-side hepaticoduodenostomy (HD) has not been extensively studied. The aim of this study was to evaluate the results of endoscopic management of HD. The medical records of 17 patients with HD stenosis who were referred to the ERCP unit between ...
Cingi Cemal C Department of Otorhinolaryngology, Osmangazi University School of Medicine, Eski┼čehir, - - 2014
Purpose: To assess the efficacy of nasal expiratory sound analysis in determining the degree of nasal obstruction. Materials and Methods: We have analyzed and recorded the expiratory nasal sounds in 18 healthy controls and in 30 patients with inferior turbinate hypertrophy before and after the administration of nasal corticosteroid treatment. ...
McGuire Michael K MK Private Practice, Houston, - - 2014
Background: In a previously reported split-mouth, randomized controlled trial, Miller Class II gingival recession defects were treated with either a connective tissue graft (CTG) (control) or recombinant human platelet-derived growth factor-BB (rhPDGF-BB) + ß-TCP (test), both in combination with a coronally advanced flap (CAF). At 6-months multiple outcome measures were ...
Kirtschig Gudula G Centre of Evidence-Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. - - 2014
Topical imiquimod cream is increasingly applied in the treatment of lentigo maligna (LM), in particular for large lesions where surgery may lead to disfiguring scars. Published studies suggest that more frequent and prolonged treatment with topical imiquimod is associated with higher efficacy. In this study we prospectively treated 27 patients ...
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