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Joo Hyun-Chel - - 2012
We retrospectively analyzed 28 years of experience with the Bentall procedure in patients with aortic valve, aortic root, and ascending aortic disease. Between March 1982 and December 2010, a total of 218 patients underwent the Bentall procedure using a composite valved conduit. The "inclusion technique" was used in 30 patients ...
Velez Federico G - - 2012
Weakening of both horizontal rectus muscles is performed for patients with Duane syndrome and significant misinnervation of the lateral rectus (LR) muscle resulting in strabismus, limitation to ocular rotations, and globe retraction. In patients with severe up-/downshoots, a Y-splitting of the LR is often recommended. The purpose of this study ...
Herndon David N - - 2012
To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center, controlled study in pediatric patients with large burns. Severe burns trigger a hypermetabolic response that persists for up to 2 years postburn. Propranolol given ...
O'Connor Ayrn - - 2012
Bark scorpion envenomation is potentially life threatening in children and traditionally treated with antivenom (AV). We sought to describe the clinical course, management, complications and outcome of children with severe scorpion envenomation treated with supportive care during a period when AV was unavailable. A retrospective chart review was performed, all ...
Bruce Beau B - - 2012
Treatment with chronic corticosteroids has been associated with frequent significant adverse effects. We hypothesized that a long-term low-dose prednisone regimen for ocular myasthenia gravis (OMG) would have a low rate of major side effects. Consecutive OMG patients from a single institution over a 16-year period and treated with ≥1 month ...
Park Moon Seok MS Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Sungnam, Kyungki 463-707, - - 2012
To predict the course of Legg-Calvé-Perthes disease (LCPD) and select between treatment options in the early stages, it is critical to have a reliable predictive classification. We examined the reliability and stability of three common classification systems for LCPD. We identified 69 patients with LCPD, who had hip radiographs taken ...
Hottinger Annalena A Medical School, University of Basel, Basel, - - 2012
Refractory status epilepticus (RSE) is the most severe manifestation of status epilepticus (SE), often requiring intensive care and therapeutic coma. It is associated with prolonged intensive care unit (ICU) and hospital stays, as well as increased morbidity and mortality. Treatment involves both intravenous anaesthetics and antiepileptic drugs (AEDs) that can ...
Tsurikisawa Naomi N Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital,18−1 Sakuradai, Minami-ku, Sagamihara,Kanagawa, Japan. - - 2012
Treatment guidelines recommend the use of inhaled corticosteroids (ICS) as first-line therapy for all stages of persistent asthma. However, it is unknown whether ICS dose reduction in adult asthmatics is compatible with maintaining asthma control. Moreover, there are no predictors of efficacy in maintaining asthma control upon ICS reduction. We ...
Lai Zhi-Wei ZW State University of New York, Upstate Medical University, College of Medicine, Syracuse, New York 13210, - - 2012
Systemic lupus erythematosus (SLE) patients exhibit T cell dysfunction, which can be regulated through mitochondrial transmembrane potential (Δψm) and mammalian target of rapamycin (mTOR) by glutathione (GSH). This randomized, double-blind, placebo-controlled study was undertaken to examine the safety, tolerance, and efficacy of the GSH precursor N-acetylcysteine (NAC). A total of ...
Lunardon Luisa L Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, - - 2012
We conducted a retrospective study of patients with pemphigus vulgaris (n = 24) and foliaceus (n = 7) treated with adjuvant rituximab to determine efficacy and adverse events. The end point for efficacy was complete remission of disease taking no or minimal therapy. Eighteen patients (58%) achieved the study end ...
Green H - - 2012
Asymptomatic bacteriuria (AB) is frequent among kidney transplant patients during the first year post transplantation. Currently, there are no clear guidelines for the antibiotic treatment of AB among these patients. We examined the outcomes of treatment versus no treatment of AB in kidney transplant patients during the first year post ...
Niotakis Georgios - - 2012
PURPOSE: The current surgical management strategies for refractory cases of idiopathic intracranial hypertension (IIH) remain unresolved. We evaluated the outcome of our paediatric patients who were offered a CSF diversion procedure in order to control their symptoms. METHODS: We retrospectively reviewed the medical notes of the patients under 16 years of ...
Del Piano Mario - - 2012
GOALS:: To implement an online, prospective collection of clinical data and outcome of patients with acute nonvariceal upper gastrointestinal bleeding (UGIB) in Italy ("Prometeo" study). BACKGROUND:: Epidemiology, clinical features, and outcomes of nonvariceal UGIB are mainly known by retrospective studies and are probably changing. STUDY:: Data were collected by 13 ...
Latus Heiner - - 2012
Preservation of the pulmonary valve, even at the expense of a mild residual stenosis, is the current surgical policy for the management of patients with tetralogy of Fallot (TOF). This study aimed to assess the long-term effect of a residual right ventricular outflow tract obstruction (RVOTO) on RV dimension and ...
Dvir Danny - - 2012
BACKGROUND: The study sought to assess the clinical profile, outcome and predictors for mortality of "real-world" high-risk severe aortic stenosis patients according to the mode of treatment assigned. METHODS: Patients were referred to a dedicated clinic for meticulous screening and multidisciplinary team assessment and 343 were finally assigned treatment (age ...
Rektor I - - 2012
OBJECTIVES: Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS: Study 207, an open-label extension (OLE) study (ClinicalTrials.gov identifier: NCT00368472), enrolled patients (18-70 years) who completed one of two randomized, placebo-controlled, dose-escalation Phase II studies. ...
Ong Chong Weng - - 2012
OBJECTIVE: To evaluate the effect of implementing the Wells score clinical prediction tool (CPT) on rationalising the use of computed tomography pulmonary angiography (CTPA) for diagnosing pulmonary embolism (PE). DESIGN AND SETTING: Within a tertiary teaching hospital, a retrospective study was conducted applying Wells score to all CTPAs ordered in ...
Mendonça Nuno - - 2012
BACKGROUND AND PURPOSE: Recent reports have indicated that mechanical thrombectomy may have potential to treat acute ischemic stroke. However, few comparative studies of neurothrombectomy devices are reported. This study aims to compare the safety and effectiveness of two retrievable stent systems in acute ischemic stroke patients. METHODS: A prospective study ...
Guinot P-G - - 2012
BACKGROUND: /st>The objective of this study was to test whether non-invasive assessment of respiratory stroke volume variation (ΔrespSV) by oesophageal Doppler monitoring (ODM) can predict fluid responsiveness during surgery in a mixed population. The predictive value of ΔrespSV was evaluated using a grey zone approach. METHODS: /st>Ninety patients monitored using ...
Zent Clive S CS Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
Thirty-three previously untreated patients with high-risk chronic lymphocytic leukemia (CLL) were treated before meeting standard criteria with alemtuzumab and rituximab. Granulocyte macrophage colony stimulating factor (GM-CSF) was added to the regimen to determine whether it would improve treatment efficacy without increasing toxicity. High risk was defined as at least one ...
Zheng Lu L Harvard School of Public Health, Boston, MA, USA. - - 2013
HIV-1-infected individuals with plasma RNA<50 copies/ml on antiretroviral therapy (ART) may have residual, low-level viraemia detectable by PCR assays that are able to detect a single copy of viral RNA (single-copy assay [SCA]). The clinical predictors of residual viraemia in patients on long-term suppressive ART are not yet fully understood. ...
Tuzel Emre - - 2012
Objective: Percutaneous nephrolithotomy (PCNL) is considered to be a clean contaminated surgical procedure and all patients are recommended to receive antibiotic prophylaxis before the operation to prevent septic events. The aim of the present study is to prospectively compare two different protocols of antibiotic prophylaxis in PCNL. Methods: Seventythree patients ...
Witt Daniel M - - 2012
QUESTION In patients with symptomatic pulmonary embolism (PE), what are the effects of rivaroxaban compared with usual care on recurrent venous thromboembolism (VTE) and bleeding? METHODS DESIGN Randomized controlled trial (EINSTEIN-Pulmonary Embolism Study). ClinicalTrials.gov NCT00439777. ALLOCATION Concealed.* BLINDING Blinded* (outcome adjudication committee and {data analysts}†). FOLLOW-UP PERIOD Mean 9 months. ...
Friedman Danielle Novetsky - - 2012
BACKGROUND: Data on long-term outcomes of survivors of extra-ocular retinoblastoma are lacking. The authors sought to provide the first report characterizing long-term outcomes among survivors of extra-ocular retinoblastoma. PROCEDURE: Retrospective analysis of long-term medical outcomes in 19 survivors of extra-ocular retinoblastoma treated between 1992 and 2009. Severity of outcomes was ...
Spry N A - - 2012
Background:To examine changes to whole body and regional lean mass (LM) and fat mass (FM) over 33 months of intermittent androgen suppression therapy (IAST).Methods:Phase II cohort study of 72 prostate cancer patients without metastatic bone disease. Patients received flutamide 250 mg tid and leuprolide 22.5 mg three monthly depot for the 9-month ...
Wu Yung-Tsan - - 2012
Cerebellar hemorrhage (CH) is considered a predictive factor for poor outcome after intracranial hemorrhage because of the high risk of brainstem compression. Hence, predictors of early mortality in patients with spontaneous CH are clinically valuable. However, the predictors of death within 7 days of CH onset have not yet been studied. ...
Ticha Veronika - - 2012
OBJECTIVES: To evaluate safety and efficacy of add-on low-dose azathioprine or interferon (IFN)-beta in patients with active multiple sclerosis despite monotherapy. METHODS: This retrospective observational study evaluated 5-year data from 85 patients with active multiple sclerosis despite monotherapy with either IFN-beta or azathioprine, who received add-on azathioprine or IFN-beta, respectively. ...
Verrall Ayesha J - - 2012
OBJECTIVES: Recently published guidelines on the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections recommend against administering vancomycin by continuous infusion on the basis of insufficient studies comparing this with intermittent infusion. We compared outcomes of patients treated with continuous infusion and intermittent infusion of vancomycin. PATIENTS AND METHODS: Data for ...
McBride Andrew - - 2012
INTRODUCTION: Correct acetabular component positioning during total hip arthroplasty affects the restoration of normal biomechanics, component wear and failure rates. This study examined whether a patient's body mass index (BMI) affects the accuracy of acetabular component placement in terms of the post-operative abduction angle. METHODS: This was a retrospective review ...
Brun-Buisson Christian - - 2012
QUESTION Does drotrecogin alfa (activated) (DrotAA) reduce mortality in patients with septic shock? METHODS DESIGN Randomized placebo-controlled trial (Prospective Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis and Septic Shock [PROWESS-SHOCK] study). ClinicalTrials.gov NCT00604214. ALLOCATION Concealed.* BLINDING Blinded* (patients, clinicians, investigators, and sponsors). FOLLOW-UP PERIOD 90 days. SETTING ...
Conaghan Philip G - - 2012
OBJECTIVES: This randomised, double-blind, placebo-controlled phase IIIb study evaluated the impact of abatacept on MRI pathology as a primary outcome in methotrexate (MTX)-refractory patients with rheumatoid arthritis. METHODS: Patients received intravenous abatacept (∼10 mg/kg) or placebo, on background MTX, for 4 months, followed by an 8-month open-label extension (OLE; all ...
Spindler Kurt P KP Vanderbilt University Medical Center, 4200 Medical Center East, South Tower, 1215 21st Avenue South, Nashville, Tennessee 37232-8774, USA. - - 2013
Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. Primary ACL reconstruction (ACLR) has in general been effective at restoring ...
Di Biagio Antonio A Infectious Diseases, IRCCS San Martino Hospital-IST, Genoa, Italy. - - 2013
To explore the durability of three first-line tenofovir/emtricitabine-based regimens in combination with atazanavir/ritonavir, efavirenz or lopinavir/ritonavir in HIV-1-infected patients. A retrospective, longitudinal, multicentre analysis of adult patients enrolled in the Antiretroviral Resistance Cohort Analysis (ARCA), a national prospective observational cohort of HIV-1-infected patients followed up at more than 100 clinical ...
Bosma Lvae - - 2012
OBJECTIVE: To study the relationships between 1-2 year changes in well-known physician-rated measurements (Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT)) and the long-term (≥ 5 years) outcome in patient-reported outcome (PRO) measures (Multiple Sclerosis Impact Scale (MSIS-29), Multiple Sclerosis Walking Scale (MSWS-12)) that reflect ...
Grijsen Marlous L - - 2012
Background We assessed whether quadruple or triple-class therapy for the initial treatment of HIV-1 infection provides a virological benefit over standard triple therapy in patients with a very high plasma viraemia.Design National observational HIV cohort in the Netherlands.Methods Inclusion criteria were age ≥18 years, treatment-naïve, plasma viral load (pVL) ≥500.000 ...
Pi Yan - - 2012
Neurothrombectomy is being used increasingly for the treatment of acute ischemic stroke. To assess the recanalization rates and clinical outcomes of patients treated with neurothrombectomy, we searched the CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedical Literature), MEDLINE and EMBASE databases to 2011 and summarized the outcome data of patients ...
Matsukawa Yoshihisa - - 2012
AIMS: To investigate the factors responsible for failure in improvement of subjective symptoms following silodosin treatment on the basis of findings of a pressure-flow study (PFS). METHODS: A post hoc analysis of a prospective study to investigate the efficacy of silodosin in patients with BPH was conducted, and 104 patients ...
Noel Gary J - - 2012
A randomized, investigator-blind, multicenter phase 2 trial involving patients with complicated skin and skin structure infections (cSSSI) compared the safety and efficacy of omadacycline, a broad-spectrum agent with activity against methicillin-resistant Staphylococcus aureus (MRSA), to those of linezolid (with or without aztreonam). Patients were randomized 1:1 to omadacycline (100 mg ...
Witzig T E TE Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, MN, - - 2013
Patients with asymptomatic (smoldering) multiple myeloma (AMM) have a high risk of transformation to active multiple myeloma (MM). Bisphosphonates such as zoledronic acid (ZLD) reduce skeletal events in MM and the immunomodulatory agent thalidomide (Thal) has proven effectiveness in active MM. We hypothesized that treatment with Thal and ZLD would ...
Synder Marek - - 2012
The goal of the study was to evaluate long-term results of hip arthroplasty in patients with ceramic-on-ceramic articulation. The follow-up involved 220 primary total hip arthroplasty procedures (188 patients, 101 women and 87 men) after implantation of the Mittelmeier cementless hip endoprosthesis. The mean age of patients at surgery was ...
Polackwich A S - - 2012
PURPOSE: Subureteral injection of dextranomer/hyaluronic acid copolymer is a minimally invasive method to treat vesicoureteral reflux. We report short and long-term success in treating secondary vesicoureteral reflux in patients with neurogenic bladder dysfunction or severe voiding dysfunction. MATERIALS AND METHODS: We performed a retrospective chart review of all subureteral injection ...
Farrugia M K - - 2012
PURPOSE: The Lima constrictor was described in 1996 as a less complex and less expensive alternative to the artificial urinary sphincter for use in cases of pediatric neuropathic sphincter incontinence. The device provides a fixed periurethral resistance which creates continence, yet allows urethral catheterization without the need to deflate the ...
Arber Anne - - 2012
OBJECTIVE: This study explores patient's experience during the first 3 months following a diagnosis of malignant pleural mesothelioma. METHODS: This study uses a grounded theory approach with semi-structured, face-to-face interviews with 10 patients during the first 3 months following diagnosis. RESULTS: The key concept that emerged from the data was this: Uncertainty ...
Savarino Lucia - - 2012
STUDY DESIGN:: Case-control study. OBJECTIVE:: To verify whether metal ions in the serum of patients bearing spinal stainless steel instrumentation, were elevated over the long-term following implantation of stainless steel prostheses, and to determine whether these levels could predict potential unfavorable outcomes. SUMMARY OF BACKGROUND DATA:: Instrumented spinal arthrodesis, the ...
Gross Bradley A - - 2012
OBJECTIVE: Although vasculopathy and de novo aneurysm formation are known complications of traditional radiation therapy, their occurrence following AVM SRS is rare and thus infrequently addressed in the literature. We sought to evaluate these phenomena through a review of our institutional experience. METHODS: Our review afforded 32 patients treated with ...
Peters Max - - 2012
PURPOSE: Current salvage treatments for recurrent prostate cancer after primary radiation therapy include radical prostatectomy, cryosurgery and brachytherapy. Because toxicity and failure rates are considerable, salvage treatments are not commonly performed. As most centers perform only one preferred salvage technique, the literature only describes single-center outcomes from a single salvage ...
Kim Eric H - - 2012
PURPOSE: We elucidate the role of endopyelotomy as a primary and secondary intervention for ureteropelvic junction obstruction in children. MATERIALS AND METHODS: We retrospectively identified 79 pediatric patients who underwent endopyelotomy for ureteropelvic junction obstruction between 1986 and 2011. Eleven patients were lost to followup and were excluded from analysis. ...
Lehrmann Heiko - - 2012
BACKGROUND:: Linear radiofrequency ablation at the cavo-tricuspid isthmus (CTI) is the treatment of choice for typical flutter. Despite a high acute success rate, in approximately 15% reconduction through the CTI may occur, eventually leading to flutter recurrence. OBJECTIVE:: We hypothesized that injection of adenosine may reveal transient CTI-reconduction and predict ...
Liu Chen-Hua - - 2012
BACKGROUND: Pegylated interferon and ribavirin for 72 weeks improve sustained virological response (SVR) in HCV genotype 1 (HCV-1) slow viral responders. Whether interleukin 28B (IL28B) single nucleotide polymorphism (SNP) genotypes and on-treatment viral responses can identify non-rapid virological response (RVR) patients who benefit from 48 or 72 weeks of therapy ...
Pan Feng - - 2012
BACKGROUND: Multiple sclerosis (MS) is a potentially debilitating autoimmune disease that affects the brain and spinal cord. Disease-modifying therapies have been shown to slow disease progression but were not believed to prolong the survival of patients with MS. The recent 21-Year Long-Term Follow-Up (21Y-LTF) study found a significant survival advantage ...
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