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Jäger Bernhard - - 2012
Hypoxic hepatitis (HH) is the most frequent cause of acute liver injury in critically ill patients. No clinical data exist about new onset of jaundice in patients with HH. This study aimed to evaluate the incidence and clinical effect of jaundice in critically ill patients with HH. Two hundred and ...
Martínez Esteban E Hospital Clínic-IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain. - - 2013
There are few clinical data on the combination abacavir/lamivudine plus raltegravir. We compared the outcomes of patients from the SPIRAL trial receiving either abacavir/lamivudine or tenofovir/emtricitabine at baseline who had taken at least one dose of either raltegravir or ritonavir-boosted protease inhibitors. For the purpose of this analysis, treatment failure ...
Fox Matthew P - - 2012
To assess outcomes over the first 7 years of antiretroviral therapy (ART) at Themba Lethu Clinic, Johannesburg, South Africa. Observational cohort study. Patients are managed according to South African National Treatment Guidelines. Mortality is ascertained through linkage with the national vital registration system. Loss to follow-up is defined as at ...
Adizie T - - 2012
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory rheumatic conditions affecting adults over the age of 50 years. Both conditions respond to initial glucocorticoid (GC) therapy. However, most patients require 12-36 months of a tapering steroid regime. Adverse events at 2 years are seen in up to 65% of patients ...
D'Ascenzo Fabrizio - - 2012
Randomised trials exploring remote ischaemic preconditioning (RIPC) in patients undergoing coronary artery bypass graft (CABG) surgery have yielded conflicting data regarding potential cardiovascular and renal protection, and are individually flawed by small sample size. Three investigators independently searched the MEDLINE, EMBASE and Cochrane databases to identify randomised trials testing RIPC ...
Kocher Mininder S - - 2012
: There is sparse literature regarding the outcomes of treatment for posterior cruciate ligament (PCL) injuries in pediatric and adolescent patients. PCL injuries are rare and are often treated conservatively. The purpose of this study was to review 2 separate cohorts of patients with pediatric and adolescent PCL injuries: those ...
Klein A - - 2012
The German Methotrexate Registry has been collecting data concerning the efficacy and safety of methotrexate (MTX) treatment since 2005. The aim of this retrospective analysis is to compare oral and parenteral MTX treatment regarding efficacy and safety. Inclusion criteria were diagnosis of juvenile idiopathic arthritis, MTX treatment for at least ...
Mangiavillano Benedetto - - 2012
  The aim of the study was to verify the use of covered removable self-expandable metal stents (CRSEMS) in benign biliary disease after a failure of traditional endoscopic treatment.   A total of 23 patients who failed traditional endoscopic therapy were enrolled in the study and treated with CRSEMS.   ...
Palabıyıkoğlu Murat - - 2012
Background/Aims: The management of non-re-sponders (NR) represents the most challenging of all aspects in the care of patients with chronic hepatitis C (CHC). The purpose of the study was to evaluate the efficacy of amantadine. Methodology: Fourty- three patients with CHC who did not respond to prior combination therapy [IFNα-2a ...
Bayer Ole - - 2012
OBJECTIVE:: To assess shock reversal and required fluid volumes in patients with septic shock. DESIGN:: Prospective before and after study comparing three different treatment periods. SETTING:: Fifty-bed single-center surgical intensive care unit. PATIENTS:: Consecutive patients with severe sepsis. INTERVENTIONS:: Fluid therapy directed at preset hemodynamic goals with hydroxyethyl starch (predominantly ...
Linsen Sabine S - - 2012
The purpose was to analyze the mandibular patterns (condylar range of motion during opening; incisal range of motion during opening, lateral excursion, and protrusion; velocity during opening and closing; mandibular rotation angle during opening and closing) in patients with alloplastic total joint replacement (TJR). Seventeen patients with different diagnoses resulting ...
Mont Michael A - - 2012
Total knee arthroplasty (TKA) is one of the most successful orthopaedic procedures with 10 to 20 year survivorships from multiple studies of greater than 95% [1-3]. These success rates typically apply to patients over 70 years of age who may only want to return to activities of daily living. However, ...
Siddiq Farhan - - 2012
Recent studies from selected centers have shown that early surgical treatment of aneurysms in subarachnoid hemorrhage (SAH) patients can improve outcomes. These results have not been validated in clinical practice at large. To identify factors and outcomes associated with timing of ruptured intracranial aneurysm obliteration treatment in patients with SAH ...
Gottlieb A B - - 2012
Etanercept plus methotrexate combination therapy has not been adequately investigated in psoriasis. To evaluate etanercept plus methotrexate vs. etanercept monotherapy in patients with moderate to severe plaque psoriasis who had not failed prior methotrexate or tumour necrosis factor-inhibitor therapy. Patients received etanercept 50 mg twice weekly for 12 weeks followed ...
Joo Hyun-Chel - - 2012
We retrospectively analyzed 28 years of experience with the Bentall procedure in patients with aortic valve, aortic root, and ascending aortic disease. Between March 1982 and December 2010, a total of 218 patients underwent the Bentall procedure using a composite valved conduit. The "inclusion technique" was used in 30 patients ...
Velez Federico G - - 2012
Weakening of both horizontal rectus muscles is performed for patients with Duane syndrome and significant misinnervation of the lateral rectus (LR) muscle resulting in strabismus, limitation to ocular rotations, and globe retraction. In patients with severe up-/downshoots, a Y-splitting of the LR is often recommended. The purpose of this study ...
Herndon David N - - 2012
To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center, controlled study in pediatric patients with large burns. Severe burns trigger a hypermetabolic response that persists for up to 2 years postburn. Propranolol given ...
O'Connor Ayrn - - 2012
Bark scorpion envenomation is potentially life threatening in children and traditionally treated with antivenom (AV). We sought to describe the clinical course, management, complications and outcome of children with severe scorpion envenomation treated with supportive care during a period when AV was unavailable. A retrospective chart review was performed, all ...
Bruce Beau B - - 2012
Treatment with chronic corticosteroids has been associated with frequent significant adverse effects. We hypothesized that a long-term low-dose prednisone regimen for ocular myasthenia gravis (OMG) would have a low rate of major side effects. Consecutive OMG patients from a single institution over a 16-year period and treated with ≥1 month ...
Park Moon Seok MS Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Sungnam, Kyungki 463-707, - - 2012
To predict the course of Legg-Calvé-Perthes disease (LCPD) and select between treatment options in the early stages, it is critical to have a reliable predictive classification. We examined the reliability and stability of three common classification systems for LCPD. We identified 69 patients with LCPD, who had hip radiographs taken ...
Hottinger Annalena A Medical School, University of Basel, Basel, - - 2012
Refractory status epilepticus (RSE) is the most severe manifestation of status epilepticus (SE), often requiring intensive care and therapeutic coma. It is associated with prolonged intensive care unit (ICU) and hospital stays, as well as increased morbidity and mortality. Treatment involves both intravenous anaesthetics and antiepileptic drugs (AEDs) that can ...
Tsurikisawa Naomi N Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital,18−1 Sakuradai, Minami-ku, Sagamihara,Kanagawa, Japan. - - 2012
Treatment guidelines recommend the use of inhaled corticosteroids (ICS) as first-line therapy for all stages of persistent asthma. However, it is unknown whether ICS dose reduction in adult asthmatics is compatible with maintaining asthma control. Moreover, there are no predictors of efficacy in maintaining asthma control upon ICS reduction. We ...
Lai Zhi-Wei ZW State University of New York, Upstate Medical University, College of Medicine, Syracuse, New York 13210, - - 2012
Systemic lupus erythematosus (SLE) patients exhibit T cell dysfunction, which can be regulated through mitochondrial transmembrane potential (Δψm) and mammalian target of rapamycin (mTOR) by glutathione (GSH). This randomized, double-blind, placebo-controlled study was undertaken to examine the safety, tolerance, and efficacy of the GSH precursor N-acetylcysteine (NAC). A total of ...
Lunardon Luisa L Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, - - 2012
We conducted a retrospective study of patients with pemphigus vulgaris (n = 24) and foliaceus (n = 7) treated with adjuvant rituximab to determine efficacy and adverse events. The end point for efficacy was complete remission of disease taking no or minimal therapy. Eighteen patients (58%) achieved the study end ...
Green H - - 2012
Asymptomatic bacteriuria (AB) is frequent among kidney transplant patients during the first year post transplantation. Currently, there are no clear guidelines for the antibiotic treatment of AB among these patients. We examined the outcomes of treatment versus no treatment of AB in kidney transplant patients during the first year post ...
Niotakis Georgios - - 2012
PURPOSE: The current surgical management strategies for refractory cases of idiopathic intracranial hypertension (IIH) remain unresolved. We evaluated the outcome of our paediatric patients who were offered a CSF diversion procedure in order to control their symptoms. METHODS: We retrospectively reviewed the medical notes of the patients under 16 years of ...
Del Piano Mario - - 2012
GOALS:: To implement an online, prospective collection of clinical data and outcome of patients with acute nonvariceal upper gastrointestinal bleeding (UGIB) in Italy ("Prometeo" study). BACKGROUND:: Epidemiology, clinical features, and outcomes of nonvariceal UGIB are mainly known by retrospective studies and are probably changing. STUDY:: Data were collected by 13 ...
Latus Heiner - - 2012
Preservation of the pulmonary valve, even at the expense of a mild residual stenosis, is the current surgical policy for the management of patients with tetralogy of Fallot (TOF). This study aimed to assess the long-term effect of a residual right ventricular outflow tract obstruction (RVOTO) on RV dimension and ...
Dvir Danny - - 2012
BACKGROUND: The study sought to assess the clinical profile, outcome and predictors for mortality of "real-world" high-risk severe aortic stenosis patients according to the mode of treatment assigned. METHODS: Patients were referred to a dedicated clinic for meticulous screening and multidisciplinary team assessment and 343 were finally assigned treatment (age ...
Rektor I - - 2012
OBJECTIVES: Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS: Study 207, an open-label extension (OLE) study (ClinicalTrials.gov identifier: NCT00368472), enrolled patients (18-70 years) who completed one of two randomized, placebo-controlled, dose-escalation Phase II studies. ...
Ong Chong Weng - - 2012
OBJECTIVE: To evaluate the effect of implementing the Wells score clinical prediction tool (CPT) on rationalising the use of computed tomography pulmonary angiography (CTPA) for diagnosing pulmonary embolism (PE). DESIGN AND SETTING: Within a tertiary teaching hospital, a retrospective study was conducted applying Wells score to all CTPAs ordered in ...
Mendonça Nuno - - 2012
BACKGROUND AND PURPOSE: Recent reports have indicated that mechanical thrombectomy may have potential to treat acute ischemic stroke. However, few comparative studies of neurothrombectomy devices are reported. This study aims to compare the safety and effectiveness of two retrievable stent systems in acute ischemic stroke patients. METHODS: A prospective study ...
Guinot P-G - - 2012
BACKGROUND: /st>The objective of this study was to test whether non-invasive assessment of respiratory stroke volume variation (ΔrespSV) by oesophageal Doppler monitoring (ODM) can predict fluid responsiveness during surgery in a mixed population. The predictive value of ΔrespSV was evaluated using a grey zone approach. METHODS: /st>Ninety patients monitored using ...
Zent Clive S CS Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
Thirty-three previously untreated patients with high-risk chronic lymphocytic leukemia (CLL) were treated before meeting standard criteria with alemtuzumab and rituximab. Granulocyte macrophage colony stimulating factor (GM-CSF) was added to the regimen to determine whether it would improve treatment efficacy without increasing toxicity. High risk was defined as at least one ...
Zheng Lu L Harvard School of Public Health, Boston, MA, USA. - - 2013
HIV-1-infected individuals with plasma RNA<50 copies/ml on antiretroviral therapy (ART) may have residual, low-level viraemia detectable by PCR assays that are able to detect a single copy of viral RNA (single-copy assay [SCA]). The clinical predictors of residual viraemia in patients on long-term suppressive ART are not yet fully understood. ...
Tuzel Emre - - 2012
Objective: Percutaneous nephrolithotomy (PCNL) is considered to be a clean contaminated surgical procedure and all patients are recommended to receive antibiotic prophylaxis before the operation to prevent septic events. The aim of the present study is to prospectively compare two different protocols of antibiotic prophylaxis in PCNL. Methods: Seventythree patients ...
Witt Daniel M - - 2012
QUESTION In patients with symptomatic pulmonary embolism (PE), what are the effects of rivaroxaban compared with usual care on recurrent venous thromboembolism (VTE) and bleeding? METHODS DESIGN Randomized controlled trial (EINSTEIN-Pulmonary Embolism Study). ClinicalTrials.gov NCT00439777. ALLOCATION Concealed.* BLINDING Blinded* (outcome adjudication committee and {data analysts}†). FOLLOW-UP PERIOD Mean 9 months. ...
Friedman Danielle Novetsky - - 2012
BACKGROUND: Data on long-term outcomes of survivors of extra-ocular retinoblastoma are lacking. The authors sought to provide the first report characterizing long-term outcomes among survivors of extra-ocular retinoblastoma. PROCEDURE: Retrospective analysis of long-term medical outcomes in 19 survivors of extra-ocular retinoblastoma treated between 1992 and 2009. Severity of outcomes was ...
Spry N A - - 2012
Background:To examine changes to whole body and regional lean mass (LM) and fat mass (FM) over 33 months of intermittent androgen suppression therapy (IAST).Methods:Phase II cohort study of 72 prostate cancer patients without metastatic bone disease. Patients received flutamide 250 mg tid and leuprolide 22.5 mg three monthly depot for the 9-month ...
Wu Yung-Tsan - - 2012
Cerebellar hemorrhage (CH) is considered a predictive factor for poor outcome after intracranial hemorrhage because of the high risk of brainstem compression. Hence, predictors of early mortality in patients with spontaneous CH are clinically valuable. However, the predictors of death within 7 days of CH onset have not yet been studied. ...
Ticha Veronika - - 2012
OBJECTIVES: To evaluate safety and efficacy of add-on low-dose azathioprine or interferon (IFN)-beta in patients with active multiple sclerosis despite monotherapy. METHODS: This retrospective observational study evaluated 5-year data from 85 patients with active multiple sclerosis despite monotherapy with either IFN-beta or azathioprine, who received add-on azathioprine or IFN-beta, respectively. ...
Verrall Ayesha J - - 2012
OBJECTIVES: Recently published guidelines on the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections recommend against administering vancomycin by continuous infusion on the basis of insufficient studies comparing this with intermittent infusion. We compared outcomes of patients treated with continuous infusion and intermittent infusion of vancomycin. PATIENTS AND METHODS: Data for ...
McBride Andrew - - 2012
INTRODUCTION: Correct acetabular component positioning during total hip arthroplasty affects the restoration of normal biomechanics, component wear and failure rates. This study examined whether a patient's body mass index (BMI) affects the accuracy of acetabular component placement in terms of the post-operative abduction angle. METHODS: This was a retrospective review ...
Brun-Buisson Christian - - 2012
QUESTION Does drotrecogin alfa (activated) (DrotAA) reduce mortality in patients with septic shock? METHODS DESIGN Randomized placebo-controlled trial (Prospective Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis and Septic Shock [PROWESS-SHOCK] study). ClinicalTrials.gov NCT00604214. ALLOCATION Concealed.* BLINDING Blinded* (patients, clinicians, investigators, and sponsors). FOLLOW-UP PERIOD 90 days. SETTING ...
Conaghan Philip G - - 2012
OBJECTIVES: This randomised, double-blind, placebo-controlled phase IIIb study evaluated the impact of abatacept on MRI pathology as a primary outcome in methotrexate (MTX)-refractory patients with rheumatoid arthritis. METHODS: Patients received intravenous abatacept (∼10 mg/kg) or placebo, on background MTX, for 4 months, followed by an 8-month open-label extension (OLE; all ...
Spindler Kurt P KP Vanderbilt University Medical Center, 4200 Medical Center East, South Tower, 1215 21st Avenue South, Nashville, Tennessee 37232-8774, USA. - - 2013
Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. Primary ACL reconstruction (ACLR) has in general been effective at restoring ...
Di Biagio Antonio A Infectious Diseases, IRCCS San Martino Hospital-IST, Genoa, Italy. - - 2013
To explore the durability of three first-line tenofovir/emtricitabine-based regimens in combination with atazanavir/ritonavir, efavirenz or lopinavir/ritonavir in HIV-1-infected patients. A retrospective, longitudinal, multicentre analysis of adult patients enrolled in the Antiretroviral Resistance Cohort Analysis (ARCA), a national prospective observational cohort of HIV-1-infected patients followed up at more than 100 clinical ...
Bosma Lvae - - 2012
OBJECTIVE: To study the relationships between 1-2 year changes in well-known physician-rated measurements (Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT)) and the long-term (≥ 5 years) outcome in patient-reported outcome (PRO) measures (Multiple Sclerosis Impact Scale (MSIS-29), Multiple Sclerosis Walking Scale (MSWS-12)) that reflect ...
Grijsen Marlous L - - 2012
Background We assessed whether quadruple or triple-class therapy for the initial treatment of HIV-1 infection provides a virological benefit over standard triple therapy in patients with a very high plasma viraemia.Design National observational HIV cohort in the Netherlands.Methods Inclusion criteria were age ≥18 years, treatment-naïve, plasma viral load (pVL) ≥500.000 ...
Pi Yan - - 2012
Neurothrombectomy is being used increasingly for the treatment of acute ischemic stroke. To assess the recanalization rates and clinical outcomes of patients treated with neurothrombectomy, we searched the CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedical Literature), MEDLINE and EMBASE databases to 2011 and summarized the outcome data of patients ...
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