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Salnikov George E - - 2013
Degenerate 1,2-shift of methylethynyl group in long-lived 9,10-dimethyl-9-methylethynyl-phenanthrenium ion has been detected by NMR. This is the first example of ethynyl migration in a long-lived carbocation.
Kurita Akira - - 2013
BACKGROUND AND STUDY AIMS: Biliary complications are one of the most serious morbidities after liver transplantation. Inside-stent is a plastic stent placed above the sphincter of Oddi without endoscopic sphincterotomy against biliary strictures. Our aims were to analyze the long-term efficacy of inside-stent placement in patients with biliary stricture after ...
Macdonald R Loch - - 2013
We report here results of a randomized, double-blind, placebo-controlled study ( http://www.ClinicalTrials.gov , NCT00558311) that investigated the effect of clazosentan (5 mg/h, n = 768) or placebo (n = 389) administered for up to 14 days in patients with aneurysmal subarachnoid hemorrhage (SAH) repaired by surgical clipping. The primary endpoint ...
Gremese Elisa - - 2013
Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the inflammatory burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents a risk factor for a poor remission rate in RA patients requiring anti-tumor necrosis factor α (anti-TNFα) therapy for progressive and active ...
Muthukumar K - - 2013
The literature regarding clinical outcomes following day 5/6 vitrified warmed blastocysts transfer has been conflicting. We decided to evaluate and compare the clinical outcomes following vitrified warmed day 5/6 blastocyst transfer using a solid surface vitrification protocol with fresh blastocyst transfers. University teaching hospital. A total of 249 women were ...
Bratanic Andre - - 2013
To identify predictive factors of rebleeding and mortality after endoscopic therapy in patients with high risk peptic ulcers. Patients hospitalized due to bleeding from high-risk peptic ulcers (Forrest classes Ia, Ib, IIa and IIb) during a five-year study, received endoscopic hemostatic therapy (diluted epinephrine injection, clipping or both) in addition ...
Gillette Blake P BP Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, - - 2013
The use of antifibrinolytic medications in hip and knee arthroplasty reduces intraoperative blood loss and decreases transfusion rates postoperatively. Tranexamic acid (TXA) specifically has not been associated with increased thromboembolic (TE) complications, but concerns remain about the risk of symptomatic TE events, particularly when less aggressive chemical prophylaxis methods such ...
Foran Jared R H JR Panorama Orthopedics and Spine Center, Golden, CO, USA. - - 2013
In a previously reported series of 51 patients with 62 cemented, fixed-bearing unicompartmental knee arthroplasties, we reported a 10-year, 98% survival rate with an average knee score of 92 points. The survivorship and modes of failure past 10 years are incompletely understood. At 15-year followup we sought to determine (1) ...
Callaghan John J JJ University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. - - 2013
Modular tibial trays have been utilized in TKA for more than 20 years. However, concerns have been raised about modular implants and it is unclear whether these devices are durable in the long term. We determined (1) survival, (2) relationship of age and polyethylene thickness with revision, (3) function, and ...
De Meyer Sandra - - 2012
In the Phase 3 REALIZE study, 662 genotype 1 hepatitis C virus (HCV)-infected patients with prior peginterferon/ribavirin treatment failure (including relapsers, partial, and null responders) were randomized to 12 weeks of telaprevir given immediately (T12/PR48) or following 4 weeks of peginterferon/ribavirin (lead-in T12/PR48), or 12 weeks of placebo (PR48), combined ...
Rinaldi Michele M Dipartimento di Oftalmologia, Seconda Università degli Studi di Napoli, - - 2012
To study whether morphologic (foveal thickness, FT) variations of clinically significant macular oedema (CMO) in patients suffering from diabetes following intravitreal pegaptanib sodium (IVP) injection were associated with functional [macular sensitivity (MS) and colour discrimination (CD)] changes. A longitudinal, interventional, non-randomized study was performed. FT was assessed by optical coherence ...
Donath Lars L Centre for Vascular Medicine and Department of Medicine III, Division of Angiology, Dresden, - - 2012
In large randomized trials, thromboprophylaxis with fondaparinux in major orthopaedic surgery (MOS) has been shown to be superior to low molecular weight heparin (LMWH) prophylaxis with comparable safety. However, patients treated under trial conditions are different from unselected patients and efficacy and safety outcomes may be different in unselected patients ...
Yasunaga Yuji Y Department of Artificial Joints & Biomaterials, Hiroshima University, Hiroshima, Japan. - - 2012
Hip dysplasia is the most common cause of secondary osteoarthritis (OA). Periacetabular osteotomy (PAO) or rotational acetabular osteotomy (RAO) has been used as a joint-preserving procedure. However, the patient selection criteria are not clearly defined. Based on a systematic review, we identified reported patient selection criteria for PAO or RAO. ...
Call Conley B - - 2012
The aim of this study was to investigate the effect of orbicularis oculi weakness on meibomian gland morphology using infrared meibography. This was a cross-sectional study. Patients were recruited from the University of Iowa Hospitals and Clinics. Inclusion criteria required the patient to be at least 18 years of age ...
Rihn Jeffrey A - - 2012
Retrospective subgroup analysis of prospectively collected data according to treatment received. The purpose of this study was to determine whether obesity affects treatment outcomes for lumbar stenosis (SpS) and degenerative spondylolisthesis (DS). Obesity is thought to be associated with increased complications and potentially less favorable outcomes after the treatment of ...
Hartmann Albrecht - - 2012
Owing to concerns attributable to problems associated with metal-on-metal bearing surfaces, current evidence for the use of hip resurfacing is unclear. Survival rates reported from registries and individual studies are controversial and the limited long-term studies do not conclusively allow one to judge whether hip resurfacing is still a reasonable ...
Devane Peter A - - 2012
Despite advances in primary THA, dislocation remains a common complication. In New Zealand (NZ), dislocations are reported to the National Joint Registry (NJR) only when prosthetic components are revised in the treatment of a dislocation. Closed reductions of dislocated hips are not recorded by the NJR. We compared the true ...
Ollivier Matthieu - - 2012
Return to sport is a key patient demand after hip arthroplasty and some patients are even involved in high-impact sports. Although polyethylene wear is related to the number of cycles and the importance of the load, it is unclear whether high-impact sport per se influences THA durability. Therefore, we compared ...
Johnston Victoria V London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. - - 2012
Without resistance tests, deciding which patients with virological failure should switch to second-line antiretroviral therapy (ART) is difficult. The factors influencing this decision are poorly understood. We assess predictors of switching regimens after virological failure. Retrospective cohort study using clinical data from a South African ART program with 6-monthly viral ...
Raza Muhammad N MN Royal Devon and Exeter Hospital, Exeter, UK. - - 2012
The use and timing of steroids in the management of acute tubulointerstitial nephritis (ATIN) remains debatable. To determine the incidence and aetiology of ATIN in our unit, and to examine trends in the use of steroids and their impact on renal outcomes. Patients with a histological diagnosis of ATIN over ...
Yip Kathleen K Cleveland Clinic Lerner College of Medicine, Cleveland, OH, - - 2012
Bariatric surgery results in dramatic weight loss and improves metabolic syndrome and type 2 diabetes (T2DM). However, previous studies have noted that morbidly obese patients with T2DM experience less weight loss benefits than non-diabetic patients following bariatric surgery. We sought to determine longitudinal effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) ...
Kilic Yusuf - - 2012
INTRODUCTION: Office hysteroscopy (OH) allows assessment of the uterine cavity. The aim of this study is to investigate uterine cavity of infertile patients with OH, to treat pathologies and to measure the impact of OH on live birth rates and IVF treatment costs. MATERIALS AND METHODS: 498 IVF patients were ...
Bansal Sonia - - 2012
The requirement of anesthetic drugs in a patient with an intracranial space-occupying lesion is of relevance to the neuroanesthetist. The requirement is often presumed to have reduced or at least altered. However, not much research has focused on this issue. Hence, we conducted this study to examine whether intracranial tumors ...
Hetem Robyn S - - 2012
Predicting whether behaviour could buffer the effects of climate change on long-lived mammals requires a better understanding of the long-term behavioural responses of mammals to environmental stress. Using biologging, we measured locomotor activity and microclimate selection, over eight months, in five Arabian oryx (Oryx leucoryx) living free in a Saudi ...
Faurschou Mikkel - - 2012
The NORAM (Nonrenal Wegener's Granulomatosis Treated Alternatively with Methotrexate [MTX]) trial demonstrated that MTX can replace cyclophosphamide (CYC) as remission-inducing treatment for patients with newly diagnosed early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Duration of relapse-free survival was longer among CYC-treated patients than among MTX-treated patients during short-term followup. The aim ...
Merrill Joan T - - 2012
To evaluate the safety profile of long-term belimumab therapy combined with standard therapy for systemic lupus erythematosus (SLE) in patients with active disease. Patients who were randomized to receive intravenous placebo or belimumab 1, 4, or 10 mg/kg, plus standard therapy, and completed the initial 52-week double-blind treatment period were ...
Petersen Morten - - 2012
The aim of the present study was to determine whether carvedilol-treated chronic heart failure patients have a different prognosis when stratified for a specific combination of a gain-of-function genotype of the adrenergic β-1 receptor gene (ADRB1) (Arg389-homozygous), two gain-of-function genotypes of the angiotensinogen gene (AGT) (Thr174-homozygous and Thr235-homozygous), and a ...
Visschers Ruben G J - - 2012
The present study was designed to evaluate the effects of guided treatment of patients with an enterocutaneous fistula and to evaluate the effect of prolonged period of convalescence on outcome. All consecutive patients with an enterocutaneous fistula treated between 2006 and 2010 were included in this study. Patient information was ...
Prodhan Parthak - - 2012
Acute kidney injury (AKI) is associated with significant morbidity and mortality in patients with critical illness; however, its impact on children with trauma is not fully unexplored. We hypothesized that AKI is associated with increased in-hospital mortality. A retrospective review of consecutive mechanically ventilated patients aged 0 years to 20 ...
Murphy Richard A - - 2012
Currently, boosted protease inhibitor-containing regimens are the only option after first-line regimen failure available for patients in most resource-limited settings, yet little is known about long-term adherence and outcomes. We enrolled patients with virologic failure (VF) who initiated lopinavir/ritonavir-containing second-line antiretroviral therapy (ART). Medication possession ratios were calculated using pharmacy ...
Sayadipour Amirali - - 2012
Antidepressant medications are widely used by patients requiring spinal surgery. In spite of a generally favorable safety profile of newer antidepressants, several prior studies have suggested an association between use of serotonergic antidepressants and excessive bleeding. This study was designed to determine if there was any association between antidepressant use ...
Doral Mahmut Nedim - - 2012
PURPOSE: The aim of this study was to assess the effect of immediate weight-bearing mobilisation with intensive rehabilitation on muscle strength and lower extremity functional level after endoscopy-assisted Achilles tendon repairs. METHODS: After warming up for 5 min at a self-selected intensity on a stationary bike 32 male patients were tested ...
Jäger Bernhard - - 2012
Hypoxic hepatitis (HH) is the most frequent cause of acute liver injury in critically ill patients. No clinical data exist about new onset of jaundice in patients with HH. This study aimed to evaluate the incidence and clinical effect of jaundice in critically ill patients with HH. Two hundred and ...
Martínez Esteban E Hospital Clínic-IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain. - - 2013
There are few clinical data on the combination abacavir/lamivudine plus raltegravir. We compared the outcomes of patients from the SPIRAL trial receiving either abacavir/lamivudine or tenofovir/emtricitabine at baseline who had taken at least one dose of either raltegravir or ritonavir-boosted protease inhibitors. For the purpose of this analysis, treatment failure ...
Fox Matthew P - - 2012
To assess outcomes over the first 7 years of antiretroviral therapy (ART) at Themba Lethu Clinic, Johannesburg, South Africa. Observational cohort study. Patients are managed according to South African National Treatment Guidelines. Mortality is ascertained through linkage with the national vital registration system. Loss to follow-up is defined as at ...
Adizie T - - 2012
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory rheumatic conditions affecting adults over the age of 50 years. Both conditions respond to initial glucocorticoid (GC) therapy. However, most patients require 12-36 months of a tapering steroid regime. Adverse events at 2 years are seen in up to 65% of patients ...
D'Ascenzo Fabrizio - - 2012
Randomised trials exploring remote ischaemic preconditioning (RIPC) in patients undergoing coronary artery bypass graft (CABG) surgery have yielded conflicting data regarding potential cardiovascular and renal protection, and are individually flawed by small sample size. Three investigators independently searched the MEDLINE, EMBASE and Cochrane databases to identify randomised trials testing RIPC ...
Kocher Mininder S - - 2012
: There is sparse literature regarding the outcomes of treatment for posterior cruciate ligament (PCL) injuries in pediatric and adolescent patients. PCL injuries are rare and are often treated conservatively. The purpose of this study was to review 2 separate cohorts of patients with pediatric and adolescent PCL injuries: those ...
Klein A - - 2012
The German Methotrexate Registry has been collecting data concerning the efficacy and safety of methotrexate (MTX) treatment since 2005. The aim of this retrospective analysis is to compare oral and parenteral MTX treatment regarding efficacy and safety. Inclusion criteria were diagnosis of juvenile idiopathic arthritis, MTX treatment for at least ...
Mangiavillano Benedetto - - 2012
  The aim of the study was to verify the use of covered removable self-expandable metal stents (CRSEMS) in benign biliary disease after a failure of traditional endoscopic treatment.   A total of 23 patients who failed traditional endoscopic therapy were enrolled in the study and treated with CRSEMS.   ...
Palabıyıkoğlu Murat - - 2012
Background/Aims: The management of non-re-sponders (NR) represents the most challenging of all aspects in the care of patients with chronic hepatitis C (CHC). The purpose of the study was to evaluate the efficacy of amantadine. Methodology: Fourty- three patients with CHC who did not respond to prior combination therapy [IFNα-2a ...
Bayer Ole - - 2012
OBJECTIVE:: To assess shock reversal and required fluid volumes in patients with septic shock. DESIGN:: Prospective before and after study comparing three different treatment periods. SETTING:: Fifty-bed single-center surgical intensive care unit. PATIENTS:: Consecutive patients with severe sepsis. INTERVENTIONS:: Fluid therapy directed at preset hemodynamic goals with hydroxyethyl starch (predominantly ...
Linsen Sabine S - - 2012
The purpose was to analyze the mandibular patterns (condylar range of motion during opening; incisal range of motion during opening, lateral excursion, and protrusion; velocity during opening and closing; mandibular rotation angle during opening and closing) in patients with alloplastic total joint replacement (TJR). Seventeen patients with different diagnoses resulting ...
Mont Michael A - - 2012
Total knee arthroplasty (TKA) is one of the most successful orthopaedic procedures with 10 to 20 year survivorships from multiple studies of greater than 95% [1-3]. These success rates typically apply to patients over 70 years of age who may only want to return to activities of daily living. However, ...
Siddiq Farhan - - 2012
Recent studies from selected centers have shown that early surgical treatment of aneurysms in subarachnoid hemorrhage (SAH) patients can improve outcomes. These results have not been validated in clinical practice at large. To identify factors and outcomes associated with timing of ruptured intracranial aneurysm obliteration treatment in patients with SAH ...
Gottlieb A B - - 2012
Etanercept plus methotrexate combination therapy has not been adequately investigated in psoriasis. To evaluate etanercept plus methotrexate vs. etanercept monotherapy in patients with moderate to severe plaque psoriasis who had not failed prior methotrexate or tumour necrosis factor-inhibitor therapy. Patients received etanercept 50 mg twice weekly for 12 weeks followed ...
Joo Hyun-Chel - - 2012
We retrospectively analyzed 28 years of experience with the Bentall procedure in patients with aortic valve, aortic root, and ascending aortic disease. Between March 1982 and December 2010, a total of 218 patients underwent the Bentall procedure using a composite valved conduit. The "inclusion technique" was used in 30 patients ...
Velez Federico G - - 2012
Weakening of both horizontal rectus muscles is performed for patients with Duane syndrome and significant misinnervation of the lateral rectus (LR) muscle resulting in strabismus, limitation to ocular rotations, and globe retraction. In patients with severe up-/downshoots, a Y-splitting of the LR is often recommended. The purpose of this study ...
Herndon David N - - 2012
To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center, controlled study in pediatric patients with large burns. Severe burns trigger a hypermetabolic response that persists for up to 2 years postburn. Propranolol given ...
O'Connor Ayrn - - 2012
Bark scorpion envenomation is potentially life threatening in children and traditionally treated with antivenom (AV). We sought to describe the clinical course, management, complications and outcome of children with severe scorpion envenomation treated with supportive care during a period when AV was unavailable. A retrospective chart review was performed, all ...
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