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Results 451 - 500 of 4743
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Rogers Lindsay S - - 2012
The aim of this study was to evaluate Fontan peri-operative outcomes for 771 consecutive patients. Since the initial description by Fontan, mortality associated with the Fontan operation has declined substantially. However, postoperative effusions remain a significant challenge. Effusions are a key determinant of postoperative length-of-stay and have been shown to ...
Wolf Brian R - - 2012
Total hip arthroplasty is a common surgical procedure, but little is known about longitudinal trends in associated adverse outcomes. Our objective was to describe long-term trends in demographics, comorbidities, and adverse outcomes for older patients who underwent primary and revision total hip arthroplasty. We identified a retrospective, observational cohort of ...
Ahmed Mustafa I MI Department of Medicine and Cardiovascular Disease, University of Alabama, Birmingham, AL, - - 2012
The purpose of the study was to evaluate the effect of long-term β(1)-aderergic receptor (AR) blockade on left ventricular (LV) remodeling and function in patients with chronic, isolated, degenerative mitral regurgitation (MR). Isolated MR currently has no proven therapy that attenuates LV remodeling or preserves systolic function. Thirty-eight asymptomatic subjects ...
Sabatowski Rainer R Comprehensive Pain Center (USC), University Hospital Carl Gustav Carus, Dresden, Germany. - - 2012
Prospective evaluation of the long-term efficacy and safety of the 5% lidocaine medicated plaster in patients with post-herpetic neuralgia (PHN). Patients with persisting pain for ≥3 months after acute herpes zoster and a baseline pain intensity of at least 4 on an 11-point numerical rating scale (NRS 0-10) were treated ...
Cetin Mustafa - - 2012
OBJECTIVE: Fragmented QRS complexes (fQRS) are defined as various RSR' patterns in 2 contiguous leads corresponding to a major coronary artery territory. Although the reason of association between fQRS and cardiac events was documented as cardiac fibrosis, the predictive role of fQRS was not studied for postoperative atrial fibrillation (POAF) ...
Fritz12 Jason S - - 2012
ABSTRACT RATIONALE: Six-minute walk distance (6MWD) and brain natriuretic peptide (BNP) levels at baseline and after initiation of treatment have been associated with survival in patients with pulmonary arterial hypertension (PAH). OBJECTIVES: To determine the individual and additive ability of pre- and post-treatment 6MWD and BNP to discriminate 2-year survival ...
Iborra-Moltó Carmelo - - 2012
Introduction: Studies of adherence to fluid restriction show high variability in prevalence data, as different methods of measuring IWG (interdialysis weight gain) and cut-off criteria are used. Objectives: To describe the prevalence of adherence to fluid restriction using daily IWG (criterion:&nbsp;&le;1Kg) and daily IWG adjusted for dry weight (DW) (cut-off ...
Singh Ajay K - - 2012
QUESTIONS Is volume supplementation using 24-hour sodium chloride better than 7-hour sodium bicarbonate for preventing contrast-induced nephropathy (CIN)? Is short-term sodium bicarbonate noninferior to 7-hour sodium bicarbonate? METHODS DESIGN Randomized controlled trial. ClinicalTrials.gov NCT00130598. ALLOCATION Unclear allocation concealment.* BLINDING Unblinded.* FOLLOW-UP PERIOD 48 hours and 90 days. SETTING 3 centers ...
Switzer Jeffrey A - - 2012
BACKGROUND AND PURPOSE: The effectiveness of prothrombin complex concentrate (PCC) products available in the United States that contain low levels of factor VII (3-factor PCC) has not been tested. The purpose of this study was to review our experience with 3-factor PCC (Profilnine) in the setting of warfarin-associated intracranial hemorrhage ...
Du Yi - - 2012
Bilateral acute optic neuritis (AON) is rare in adults in Western countries, but is relatively common in Asian populations. We aimed to document clinical features in Chinese patients with bilateral AON, and to identify factors that are predictive of visual acuity outcome. We reviewed 41 patients (23 males, 18 females; ...
Yukizawa Yohei - - 2012
Fondaparinux (FPX), a selective inhibitor of factor Xa, is widely used for the prophylaxis of venous thromboembolism (VTE) after total joint arthroplasty. However, the association between plasma FPX concentration and adverse events and the occurrence of VTE has not been clarified thus far. We aimed to prospectively evaluate these associations ...
Archdeacon Michael T - - 2012
OBJECTIVE:: To present clinical, radiographic and functional outcomes of patients 70 years and older with a protrusio type acetabulum fracture. DESIGN:: Retrospective case series. SETTING:: Two level 1 trauma centers. PATIENTS:: Between 11/2000 and 12/2009, 39 consecutive patients older than 70 with protrusio acetabulum fractures were enrolled. INTERVENTION:: Open reduction ...
Moriya Mitsutoshi - - 2012
Bipolar hemiarthroplasty (BHA) for idiopathic osteonecrosis of the femoral head (ONFH) is performed at our institution. The purpose of this study was to evaluate the clinical and radiographic findings after BHA for the treatment of steroid -induced ONFH. Thirty-seven hips in 27 patients were assessed (seven men, 11 hips; 20 ...
Choi Seong Jun SJ Department of Otorhinolaryngology, Konyang University, Daejeon, Republic of - - 2012
To identify clinical features and causes of recurrent or persistent benign paroxysmal positional vertigo (BPPV) and to analyze the effectiveness of frequently repeated canalith repositioning procedures (CRPs). Case series with chart review. Academic university hospital. The authors retrospectively reviewed the clinical records of 120 patients who were diagnosed with BPPV ...
Kalil Andre C AC Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5400, USA. - - 2012
Drotrecogin alfa (activated) was approved for use in severe sepsis in 2001 on the basis of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial, but controversies about its effectiveness remain. We aimed to assess effectiveness and safety of use of this drug in the past ...
Touma Z - - 2012
Objectives: To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. Methods: This is a retrospective analysis of the ...
D'Acunto C - - 2012
Over the last years, many different techniques have been utilized to treat age related wrinkles. We describe here two patients with a new type of filler adverse reaction, xanthelasma-like, that appeared after the infiltration of hyaluronic acid in the superficial dermis of the lower eyelids. Case 1 A 49-year-old caucasian ...
Tan P X - - 2012
AIM: Limb-salvage surgery has become the standard of care for extremity osteosarcoma. In this study, we investigated the survival and functional outcomes of patients with osteosarcoma around the knee who were treated with limb-salvage surgery. METHODS: We retrospectively reviewed the clinical data for 120 patients with osteosarcoma around the knee ...
Diab Aliaa A - - 2012
Objective:To investigate the effectiveness of forward head correction on three-dimensional posture parameters and functional level in adolescent idiopathic scoliotic patients.Design:A randomized controlled study with three-month follow-up.Setting:University research laboratory.Subjects:Seventy-six adolescent idiopathic scoliotic patients with Cobb angle ranged from 10° to 30° and craniovertebral angle less than 50° were randomly assigned to ...
O'Donnell Turlough M P - - 2012
We compared a cohort of patients undergoing revision of a minimal resection resurfacing unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA) with a cohort of patients undergoing primary TKA. Both cohorts were matched in terms of age, sex, and body mass index. We collected data on preoperative and postoperative ...
Kurelac Ivan - - 2012
The aim of this study was to analyze the predictive value of CXCL9, CXCL10, and CXCL11 concentrations before and after 4 and 12 weeks of treatment with pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C infected with the hepatitis C virus genotype 1. The study included 46 adult ...
Kallel S S Department of Anesthesiology and Intensive Care, Academic Medical Center Habib Bourguiba, Sfax, Tunisia. - - 2012
Determine the thresholds of procalcitonin (PCT) and N-terminal pro-B-type natriuretic peptide (Nt-pro-BNP) associated with poor prognosis after heart surgery with CPB. Prospective observational study. Academic Medical Center Habib Bourguiba. Adult patients consecutively operated for coronary or valve surgery with CPB, elective or semi-urgent. Serum concentrations of PCT and Nt-pro-BNP were ...
Shlobin Oksana A - - 2012
BACKGROUND: Sildenafil was the only phosphodiesterase-5 inhibitor available for the treatment of pulmonary arterial hypertension (PAH) until the approval and availability of once-daily tadalafil. Since no direct comparative study is likely to be performed between these agents, we sought to evaluate the feasibility of transitioning stable PAH patients from sildenafil ...
Genovese Mark C - - 2012
To evaluate abatacept safety and efficacy over 5 years in patients with rheumatoid arthritis (RA) who had inadequate response to anti-tumor necrosis factor (TNF) therapy in the ATTAIN trial. Patients completing the 6-month, double-blind (DB) placebo-controlled period were eligible to enter the longterm extension (LTE), where all patients received abatacept ...
Yang Rachel L - - 2012
Several treatment options exist for kidney transplant patients with tertiary hyperparathyroidism. However, the decision to endorse observation (OBS), medical therapy, or parathyroidectomy (PTX) remains controversial. We performed a retrospective cohort study of kidney transplant patients with tertiary hyperparathyroidism at a single institution over a 7-year period. Patients were classified by ...
Georgountzou A - - 2012
Aim:  To evaluate the effectiveness, safety and tolerability of propranolol as single agent treatment in patients with problematic, proliferative phase, infantile hemangiomas (IHs). Methods:  Oral propranolol was administered at a dose of 2 mg/kg/day to twenty eight children. Cardiologic evaluation was performed before treatment initiation. Hemodynamic variables and blood glucose ...
Park Do Joon - - 2012
The best treatment option for recurrent papillary thyroid carcinoma (PTC) is reoperation when the recurrent lesion is locoregional. The prognostic significance of serum Tg levels before reoperation and the association between the outcome of reoperation and Tg level remain unclear. Our study aimed to determine the outcomes of patients who ...
Barnes Geoffrey D - - 2012
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are associated with high rates of venous thromboembolism (VTE). Anticoagulants, such as warfarin, are commonly used to prevent VTE in such patients. The practice and effectiveness of warfarin in real world populations is not well documented. 595 TKA and THA patients ...
Zuraw Bruce L - - 2012
OBJECTIVE: Nanofiltered C1-inhibitor (C1INH-nf) is approved for prophylactic treatment of hereditary angioedema. This study assessed the efficacy and safety of C1INH-nf as prophylactic therapy in a large cohort of patients with hereditary angioedema. METHODS: An open-label multicenter extension study was performed involving 146 subjects with hereditary angioedema who were treated ...
Martins Gerez Fernandes - - 2012
BACKGROUND: Organic inflammatory response is a pathophysiological mechanism present at every coronary artery bypass grafting with extracorporeal circulation (CABG-ECC), the release of inflammatory mediators being one of its defense mechanisms. OBJECTIVE: To assess, in a prospective double-blind randomized and placebo-controlled study, the effects of trimetazidine (Tmz) on the inflammatory response, ...
Rodelo Joaquín R - - 2012
PURPOSE: The aim of the study was to determine whether C-reactive protein (CRP), procalcitonin (PCT), and d-dimer (DD) are markers of mortality in patients admitted to the emergency department (ED) with suspected infection and sepsis. BASIC PROCEDURES: We conducted a prospective cohort in a university hospital in Medellín, Colombia. Patients ...
Cooper Anthony Philip - - 2012
ObjectiveTo compare the results of hip arthroscopy in patients under the age of 25 with those over 25&emsp14;years.DesignFrom March 2006 until May 2010, data were collected on all patients who underwent hip arthroscopy for symptomatic intra-articular hip pathology. The patients were divided into two groups based on age (less than ...
Conti Alberto - - 2012
BACKGROUND: Novel facilities such as an intensive observation unit and an outpatient clinic could result in improving management of patients presenting with atrial fibrillation (AF). METHODS: This observational study enrolled 3475 patients. Group 1 (1120 patients; years 2004-2005) was managed with standard approach; group 2 (992 patients; years 2006-2007) was ...
Gremese Elisa - - 2012
BACKGROUND: To assess whether, in the real world of three early arthritis clinics, early referral could allow the best outcome, ie, remission, to be reached, and whether reaching the outcome was more dependent on therapy than on disease duration or vice versa. METHODS: 1795 patients with early arthritis (symptom duration ...
Unnanuntana Aasis A Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, Bangkok, - - 2013
We prospectively measured functional performances (Western Ontario and McMaster Universities Osteoarthritis Index, Short Form-36, 2-minute walk test, and timed get-up-and-go test) of patients who underwent total hip arthroplasty (THA) and had serum vitamin D levels tested during the preoperative evaluation. Of 219 patients, 102 (46.6%) had low vitamin D levels ...
Minami Tatsuya - - 2012
BACKGROUND: Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this systematic ...
Charlot Mette - - 2012
AimsThe benefit of extending clopidogrel treatment beyond the 12-month period recommended in current guidelines after myocardial infarction (MI) is debated. We analysed the risk of adverse cardiovascular outcomes after discontinuation of 12 months of clopidogrel treatment.Methods and resultsThis Danish retrospective nationwide study included all patients treated with clopidogrel after discharge ...
Gammelager Henrik - - 2012
ABSTRACT: INTRODUCTION: There are few studies on long-term mortality among intensive care unit (ICU) patients with acute kidney injury (AKI). We assessed the prevalence of AKI at ICU admission, its impact on mortality during one year of follow-up, and whether the influence of AKI varied in subgroups of ICU patients. ...
Broussalis E - - 2012
BACKGROUND AND PURPOSE:Revascularization of large cerebral artery occlusion is the therapeutic goal in stroke therapy. Currently, many recanalization devices are in clinical use. This study compares the outcome parameters, efficacy, and safety of the new generation of stent-retriever devices with the well-established Merci retriever.MATERIALS AND METHODS:All patients who received endovascular ...
Chen Jingyu - - 2012
PURPOSE: We reviewed the clinical and follow-up data of 89 cases with cerebral paragonimiasis and summarized the disease characteristics, diagnostic strategies and treatment experience, with an expectation of establishing standard diagnosis and treatment for cerebral paragonimiasis. METHODS: A total of 89 cases (age: 2-64years) of cerebral paragonimiasis admitted and treated ...
Cammà Calogero - - 2012
Randomized controlled trials (RCTs) show that triple therapy (TT) with peginterferon alpha, ribavirin, and boceprevir (BOC) or telaprevir (TVR) is more effective than peginterferon-ribavirin dual therapy (DT) in the treatment of previously untreated patients with genotype 1 (G(1) ) chronic hepatitis C (CHC). We assessed the cost-effectiveness of TT compared ...
Akhtar N - - 2012
Itching is a common and well recognised problem following burns. As the underlying pathways involved in burns itch have been identified, different pharmacological agents have been introduced to improve the effectiveness of management regimes. We present preliminary data from an on-going study in the use of botulinum toxin as a ...
Willey Joshua Z JZ Department of Neurology, 710 West 168 Street, Box 30, New York, NY 10032, USA. - - 2012
Few studies have addressed outcomes among patients ≥80 years treated with acute stroke therapy. In this study, we outline in-hospital outcomes in (1) patients ≥80 years compared with their younger counterparts; and (2) those over >80 years receiving intra-arterial therapy (IAT) compared with those treated with intravenous recombinant tissue-type plasminogen ...
Lübbers Thomas - - 2012
BACKGROUND: Microsurgery of foraminal and extraforaminal disc herniation at the L5-S1 level remains a challenge because of the limited access by a high iliac crest, the sacral ala, large transverse processes of L5 and hidden disc fragments lateral to the zygapophyseal joint. Our aim was to present the outcome of ...
Qi Peter - - 2012
OBJECTIVES: Prostate-specific antigen (PSA) screening has increased the detection of small, organ-confined tumors, and studies suggest that these patients may have favorable outcomes following radical prostatectomy (RP). To date, there are limited data available on the outcomes of patients diagnosed with low PSA (≤4 ng/ml) who underwent RP. This study ...
Nalamachu Srinivas R - - 2012
CONTEXT: The efficacy and tolerability of once-daily hydromorphone extended release (ER) (OROS(®) hydromorphone ER, Exalgo(®), Mallinckrodt Brand Pharmaceuticals, Inc., Hazelwood, MO) in patients with chronic cancer and noncancer pain have been reported in previous studies. OBJECTIVES: The objective of this analysis was to assess the pooled safety data of OROS ...
Lattimer Christopher R - - 2012
BACKGROUND: Pulsatile flow in deep, perforating veins and varicose veins (VVs) has been described previously to support a hypothesis of arterio-venous (A-V) fistulae in the pathogenesis of VVs. Its presence has also been suggested as a cause of failure of VV treatments. However, A-V communications have never been adequately visualized ...
Fernandez-Nebro A - - 2012
Objective: This study aimed to investigate the effectiveness and safety of single and repeated courses of rituximab in patients with refractory lupus. Methods: LESIMAB is a multicenter, retrospective, longitudinal study of lupus patients who have not responded to standard therapy and have been treated with rituximab. Response rates at six ...
Lin Yiyun - - 2012
BACKGROUND: Constrictive pericarditis is a rare and disabling disease that can result in chronic fibrous thickening of the pericardium. Prompt treatment of constrictive pericarditis is necessary to limit morbidity and mortality. METHODS: We analyzed the clinical details of 51 constrictive pericarditis patients who underwent surgery from January 2005 to December ...
Albarel Frédérique - - 2012
Given the new therapeutic options in acromegaly, it seemed important to evaluate the outcome of operated acromegalic patients today. OBJECTIVE: To analyze the characteristics and short- and long-term surgical outcome of patients who underwent transsphenoidal surgery for a growth hormone (GH)-secreting adenoma in our center and to determine predictive factors ...
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