Search Results
Results 351 - 400 of 1431
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Ghosh S - - 2009
A prospective hospital based blinded study was carried out in an orthopedics department in a medical college hospital of Kolkata, West Bengal, India, with the objective of assessing the role of pre-operative high-sensitivity C-reactive protein (hsCRP) level in predicting postoperative complications in replacement arthroplasty. One hundred and twenty one study ...
Gupta Sampa Dutta - - 2009
Hypomagnesaemia is a common complication after cardiopulmonary bypass (CPB) and predisposes to the development of cardiac arrhythmias. Previous studies showed that intravenous magnesium reduces the incidence of postoperative cardiac arrhythmias but it also inhibits platelet function. Our aim was to compare the postoperative blood loss in patients not receiving magnesium ...
Llewelyn C A CA National Blood Service (NBS)/Medical Research Council Clinical Studies Unit, NHS Blood and Transplant (NHSBT), Cambridge, - - 2009
Previous studies of blood use have used different methods to obtain and classify transfusion indications. Before undertaking a national study of transfusion recipients, a pilot study was performed over 2 months at two teaching and two district general hospitals to match information from hospital transfusion laboratories with clinical coding data ...
Tobian Aaron A R - - 2009
BACKGROUND: Mortality increases as hemoglobin (Hb) levels fall. Among severely anemic patients, the clinical course, cause of death, and whether there are any warning signs before death are unknown. STUDY DESIGN AND METHODS: A retrospective cohort study was performed of surgical patients who refused red blood cell transfusions for religious ...
Tempe Deepak K - - 2009
OBJECTIVE: To evaluate and compare early hemodynamic changes after elective mitral valve replacement (MVR) in patients with severe and mild pulmonary arterial hypertension (PAH). DESIGN: A prospective observational study. SETTING: University-affiliated hospital. PARTICIPANTS: Sixty patients undergoing elective MVR. INTERVENTIONS: The patients were divided into 2 equal groups based on the ...
Feng Jing - - 2009
To develop an intermittent hypoxia/reoxygenation (IH/ROX) rabbit carotid artery model and then investigate the inflammation status of rabbit carotid artery endothelium after IH exposure and its relationship with leptin. After anesthetization, rabbit's right common carotid artery was cleared of surrounding tissue with anatomic microscope, cannulated to its distal part and ...
Zehtabchi Shahriar - - 2009
OBJECTIVES: Coagulopathy is common after severe trauma and occurs very early after the initial insult. Some investigators have suggested early and aggressive treatment of the trauma-induced coagulopathy by transfusion of fresh-frozen plasma (FFP) and packed red blood cells (PRBC) in a 1:1 ratio. This evidence-based emergency medicine (EBM) review evaluates ...
Stager, Andrew Carl
The main purpose of this study was to determine the prognosis after Popliteal Artery Entrapment Syndrome (PAES) surgery for young, active individuals. The hypothesis was that after PAES surgery, full restoration of activity level and sport performance with improvements in exercise-induced leg pain (EILP) and activity tolerance occurs when the ...
Santarpino G - - 2009
AIM: Recent reports have shown anti-inflammatory effects with conventional hemofiltration (CUF) in patients undergoing cardiopulmonary bypass (CPB). The aim of this study was to evaluate the immunological and the hemodynamic response to CUF or metilprednisolone in patients undergoing coronary artery bypass grafting. METHODS: Twenty-four consecutive patients were prospectively randomized to ...
Yanagawa Youichi - - 2009
PURPOSE: The aim of this study was to investigate whether laboratory findings on arrival may be useful in predicting the outcome of out-of-hospital cardiopulmonary arrest (CPA). METHODS: Between January 2005 and September 2007, a medical chart review was retrospectively performed for CPA. The individual medical records were reviewed for the ...
Hudetz Judith A - - 2009
To determine if ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect in patients undergoing cardiac surgery using cardiopulmonary bypass. A prospective randomized study. A Veterans Affairs medical center. Cardiac surgical patients. Patients at least 55 years of age randomly received placebo (0.9% saline, n = 29) or an intravenous ...
Pehlivan Berrin - - 2009
AIM: To assess the influence of hemoglobin (Hb) levels in locally advanced head and neck cancer (LAHNC) patients treated with surgery and postoperative radiotherapy (PORT). MATERIAL AND METHODS: Pre- and postoperative Hb levels were collected in 79 patients treated with surgery followed by accelerated PORT for LAHNC. Median follow-up was ...
Abrishami Amir - - 2009
PURPOSE: This systematic review aimed to evaluate the efficacy and safety of topical application of antifibrinolytic drugs to reduce postoperative bleeding and transfusion requirements in patients undergoing on-pump cardiac surgery. METHODS: We searched The Cochrane Library, MEDLINE, EMBASE and SCI-EXPANDED for all randomized controlled trials on the topic. Trial inclusion, ...
Choudhary Dharma R - - 2009
OBJECTIVE: To assess the efficacy of wheat grass juice on transfusion requirement in patients with beta thalassemia major. METHODS: Fifty-three patients of thalassemia major with a median age of 16 years were given wheat grass juice tablets. RESULTS: The Mean pre and post wheat grass therapy, the pack cell requirement ...
Gonzalez-Porras J R - - 2009
We have prospectively evaluated the efficacy of an individualized pre-operative blood saving protocol in elective total hip arthroplasty (THA) or total knee arthroplasty (TKA). The primary aim was to obtain a pre-operative haemoglobin (Hb) level of > or =14 g dL(-1). A reduction in requirements for allogeneic transfusion was considered ...
Freilich Daniel - - 2009
BACKGROUND: Vasoactivity has hampered progress of hemoglobin-based oxygen carriers (HBOCs) due to concern for adverse blood pressure responses and secondary complications. A recent formulation, highly polymerized HBOC-201 (Biopure, Cambridge, MA), has been found to be less vasoactive than prior less polymerized formulations, and to improve outcome in animal models of ...
Guzzetta Nina A - - 2009
BACKGROUND: Recent concern about the safety of aprotinin administration to adults has led to its suspension from worldwide markets. However, few studies have examined its safety in pediatric patients. Studies in children evaluating aprotinin's safety have been hindered by the heterogeneity of pediatric patients and the inconsistency of clinical protocols. ...
Dohner M Lynn - - 2009
BACKGROUND: In neonatal intensive care unit (NICU) practice, a small percentage of the patients receive a large proportion of the platelet (PLT) transfusions administered. This study sought to better define this very-high-user group. To accomplish this, records of all NICU patients in a multihospital health care system who, during a ...
Ghazy Tamer - - 2009
The aim of this work was to question the necessity of repeated administration of warm blood cardioplegia in modern cardiac surgery. A consecutive series of 4014 patients underwent cardiosurgical procedures in the period from January 2001 to December 2006 in our centre, where modified Calafiore warm blood-cardioplegic solution was used. ...
Svagzdiene Milda - - 2009
OBJECTIVE: Our study was designed to assess the incidence of atrial fibrillation, changes in serum electrolyte concentrations and urinary electrolyte excretion following coronary artery bypass grafting surgery. MATERIAL AND METHODS: A total of 165 patients who underwent elective coronary artery bypass grafting surgery at the Department of Cardiac Surgery (Heart ...
Blomgren Johan - - 2009
The aim of this study was to investigate if unsupervised measurement of saliva secretion could be used instead of supervised measurement at the dental clinic. One hundred patients attending a dental clinic for regular dental care were asked to participate (group A). A control group of 40 subjects was recruited ...
Kishimoto Kyo - - 2009
PURPOSE: Surgical procedures are being performed on elderly people with increasing frequency, but accordingly, postoperative complications and mortality rates are higher than for younger patients. We conducted this study to establish if cytokine responses after distal gastrectomy in elderly patients differ from those in younger patients. METHODS: Twenty-one patients undergoing ...
Sato Kazuomi - - 2009
The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA). The catechin group inhibited melanin synthesis in B16 melanoma cells. To elucidate the anti-melanogenic mechanism of the catechin group, ...
Perry Tjörvi E - - 2009
BACKGROUND: Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ambulatory populations. However, the influence of CRP gene variants on CRP levels during inflammatory states, such as surgery, is largely unexplored. ...
Heukelbach Jorg - - 2009
BACKGROUND: Dimeticones kill head lice by physical means. Here we assessed in a comparative bioassay the ex vivo efficacy of "NYDA sensitiv", a new two-phase dimeticone-based pediculicide similar to a product established on the market, but without fragrances. METHODS: We compared efficacy of the new product to a positive dimeticone ...
Vanhoonacker J - - 2009
Concerned about high dose starches and potential coagulopathy, we performed a double blinded randomised prospective study on the influence of gelatine or 6% HES 130/04 pump prime on postoperative blood loss and transfusion requirements after CABG surgery. METHODS: After informed consent, 157 electively scheduled patients were randomly allocated to 6% ...
Delannoy Bertrand - - 2009
INTRODUCTION: Systemic inflammatory response syndrome (SIRS) is a frequent condition after cardiopulmonary bypass (CPB) and makes conventional biological tests fail to detect postoperative sepsis. Biphasic waveform (BPW) analysis is a new biological test derived from activated partial thromboplastin time that has recently been proposed for sepsis diagnosis. The aim of ...
Vretzakis G - - 2009
Hemodilution contributes significantly to transfusion requirements in patients undergoing CABG under CPB. We hypothesised that restriction of parenteral fluids in comparison to a liberal fluid administration policy leads to less use of packed red cells in CABG operations supported by cell salvage. After consent and approval, 130 patients operated under ...
Presta Pierangela - - 2009
BACKGROUNDS/AIMS: We recently demonstrated that pulsatile cardiopulmonary bypass (CPB) versus standard linear CPB is associated with better perioperative renal function. Since older subjects have a higher risk of acute renal failure, we have extended our study to evaluate the specific impact of pulsatile CPB on the perioperative renal function in ...
Mathew P J - - 2009
Though propofol requirement is expected to decrease during cardiopulmonary bypass (CPB), a few studies have failed to demonstrate this. The factors affecting pharmacokinetics of propofol and, therefore, the requirement, are different during hypothermic and normothermic CPB. We evaluated and compared the requirement of propofol during hypothermic and normothermic CPB. Fifty ...
Takahashi Yosuke - - 2009
Di-(2-ethylhexyl)phthalate (DEHP), an excellent plasticizer for poly(vinyl chloride) (PVC), is a known endocrine-disrupting chemical. This study was designed to investigate whether a new non-DEHP bilayer tube reduced the release of DEHP, suppressed inflammatory cytokines, and altered coagulation-fibrinolysis systems. Sixteen patients undergoing coronary artery bypass grafting (CABG) were randomly assigned to ...
Chen Bao-an - - 2009
Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy. We evaluated the effect of daunorubicin (DNR)-loaded magnetic nanoparticles of Fe3O4 (MNPs-Fe3O4) on K562-n/VCR cells in vivo. K562-n and its MDR counterpart K562-n/VCR cell were inoculated into nude mice subcutaneously. The mice were randomly divided into four groups: group A ...
Spinella Philip C - - 2009
In critically ill patients the relationship between the storage age of red blood cells (RBCs) transfused and outcomes are controversial. To determine if duration of RBC storage is associated with adverse outcomes we studied critically ill trauma patients requiring transfusion. This retrospective cohort study included patients with traumatic injuries transfused ...
Fawzy Hosam - - 2009
Diffuse microvascular bleeding remains a common problem after cardiac procedures. Systemic use of antifibrinolytic reduces the postoperative blood loss. The purpose of this study was to examine the effectiveness of local application of tranexamic acid to reduce blood loss after coronary artery bypass grafting (CABG). Thirty eight patients scheduled for ...
Akbulut Mehmet - - 2009
We investigated the effects of clopidogrel on reperfusion and inflammatory process in STEMI. A total of 175 STEMI patients with similar clinical characteristics were included to this study. One was the standard pharmacological reperfusion therapy group (group 1, n : 90), who received 300 mg aspirin, 70 U/kg bolus, and ...
Elmistekawy Elsayed M - - 2009
Preoperative patients' characteristics can predict the need for perioperative blood component transfusion in cardiac surgical operations. The aim of this prospective observational study is to identify perioperative patient characteristics predicting the need for allogeneic packed red blood cell (PRBC) transfusion in isolated primary coronary artery bypass grafting (CABG) operations. 105 ...
Shishehbor Mehdi H MH Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. - - 2009
We sought to examine the short- and long-term outcomes of blood transfusion in patients presenting with ST-segment elevation myocardial infarction (STEMI). The short- and long-term consequences of blood transfusion in anemic patients with recent STEMI remain controversial. We evaluated 30-day, 6-month, and 1-year all-cause mortality among 4,131 STEMI patients enrolled ...
Guzzetta Nina A - - 2009
BACKGROUND: Increasingly, recombinant activated factor VII (rFVIIa) is used adjunctively in nonhemophiliacs to control hemorrhage unresponsive to conventional therapy in a variety of settings including postcardiopulmonary bypass (CPB). Studies examining rFVIIa administration to neonates after CPB are limited. The goal of this study was to evaluate retrospectively the clinical outcomes ...
Taghaddomi Reza Jalaeian - - 2009
OBJECTIVE: This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery. DESIGN: A prospective, randomized, double-blind, placebo-controlled study. SETTING: The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University. PARTICIPANTS: One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled ...
Hinarejos Pedro - - 2009
The aim of this study was to compare blood loss and transfusion requirements in patients undergoing computer-assisted total knee arthroplasty (TKA) and patients operated with conventional instrumentation with intra-medullar guides. A prospective randomized study of 87 patients undergoing a TKA assigned to conventional technique (n = 44) or computer-assisted surgery ...
Bakhtiary F - - 2008
BACKGROUND: Cardiopulmonary bypass is associated with systemic inflammation that may contribute to increased perioperative mortality. Depletion of circulating leukocytes may reduce the inflammatory response. We studied the effect of a leukocyte depleting filter on leukocyte activation during cardiopulmonary bypass in high risk patients. METHODS: Fifty patients undergoing coronary artery bypass ...
Martin Klaus - - 2008
BACKGROUND: Our aim was to investigate postoperative complications and mortality after administration of aprotinin compared to tranexamic acid in an unselected, consecutive cohort. METHODS: Perioperative data from consecutive cardiac surgery patients were prospectively collected between September 2005 and June 2006 in a university-affiliated clinic (n = 1188). During the first ...
Durandy Yves D - - 2008
BACKGROUND: The safety of normothermic pediatric cardiac surgery remains controversial. This study evaluated the performance of normothermic cardiopulmonary bypass (CPB) associated with intermittent warm blood cardioplegia during prolonged aortic cross-clamp time (CCT). METHODS: This retrospective study included 234 consecutive patients weighing less than 10 kg operated under CPB from August ...
Breuer Tamás - - 2009
OBJECTIVE: Recently, the safety of aprotinin administration during open-heart surgery has been debated. The aim of the study was to compare the blood sparing effect and the side effects of aprotinin and tranexamic acid in paediatric cardiac surgery patients. METHODS: Perioperative data of 199 consecutive patients weighing less than 20kg ...
Lema Guillermo - - 2009
OBJECTIVE: Renal vasoconstriction has been blamed as a cause of perioperative renal dysfunction after cardiac surgery. Endothelial function is a critical determinant of vascular tonus, including vasoconstriction. The objective of this study was to establish whether the release of the endothelial vasodilator nitric oxide (NO) or NO products is altered ...
Broder-Fingert Sarabeth - - 2009
To monitor hematological indices in otherwise healthy children with central precocious puberty who underwent frequent venous sampling as part of a longitudinal clinical research study. Thirty-four female subjects underwent frequent venous sampling (every 10-20 minutes for 8-16 hours) every 6 months for >or=3 years during and after their treatment with ...
Elwatidy Sherif - - 2008
STUDY DESIGN: This is a double blind randomized placebo controlled study, after obtaining approval of ethics committee in the hospital and informed written consent, 64 patients were randomized equally into 2 groups (tranexamic acid (TA) and placebo). OBJECTIVE: To evaluate efficacy and safety of large doses of TA on blood ...
Rimpiläinen R - - 2008
We have reviewed the results of our experience with the use of miniaturized (Mini-CPB) versus conventional (C-CPB) cardiopulmonary bypass in coronary artery bypass surgery (CABG). This study included 365 patients who underwent CABG with C-CPB and 101 patients with Mini-CPB. In-hospital mortality was lower in the C-CPB group (1.4% vs. ...
Sirvinskas E - - 2008
The aim of the study was to investigate if acute renal failure (ARF) following cardiac surgery is influenced by CPB perfusion pressure and to determine risk factors of ARF. Our research consisted of two studies. In the first study, 179 adult patients with normal preoperative renal function who had been ...
Palomero Rodríguez M A - - 2008
BACKGROUND: Coronary artery bypass graft surgery with cardiopulmonary bypass induces a systemic inflammatory response. However, when thoracic epidural anaesthesia is administered as part of a combined anesthetic technique, the stress response associated with the cardiopulmonary bypass (CPB) may be attenuated. METHODS: Twenty-two patients undergoing elective coronary artery bypass graft surgery ...
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