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Lairmore Terry C TC Baylor Scott and White Health Care and Texas A&M University System Health Science Center, College of Medicine, Temple, TX. Electronic address: - - 2014
Hyperparathyroidism (HPT) in multiple endocrine neoplasia (MEN) type 1 is associated with multiglandular parathyroid disease. Previous retrospective studies comparing subtotal parathyroidectomy (SP) and total parathyroidectomy with autotransplantation (TP/AT) have not established clearly better outcomes with either procedure. Patients were assigned randomly to either SP or TP/AT and data were collected ...
Shahnazi Mahnaz M Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, - - 2014
One of the most common complications of IUD users is bleeding and dysmenorrhea. These complications vary in the different types of IUDs. The aim of this study was to compare the bleeding and dysmenorrhea in ML CU 375 IUD and Copper T 380A IUD. This randomized double-blind controlled clinical trial ...
Maniscalco Pietro P Department of Orthopaedics and Traumatology, Piacenza Hospital, Piacenza, - - 2014
Despite current guidelines recommendations about anticoagulant prophylaxis, many studies have shown an high venous thromboembolism (VTE) incidence in patients undergoing total hip and knee arthroplasty. A number of anticoagulants are currently available, but they have some limitations that affect their applicability and consequently their effectiveness. Several new oral anticoagulants (NOACs) ...
Kawashima Makoto M Department of Dermatology, Tokyo Women's Medical University, Tokyo, - - 2014
Benzoyl peroxide (BPO) as an anti-acne medication is not yet approved in Japan. This study evaluated the efficacy and safety of a once-daily topical application of BPO 3% gel versus an inert vehicle gel in Japanese acne patients. Three hundred and sixty patients were randomized to receive BPO 3% or ...
Okada Ken-Ichi KI Second Department of Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, - - 2014
The incidence of delayed gastric emptying (DGE) is high in patients undergoing distal pancreatectomy with celiac axis en-bloc resection (DP-CAR). The medical records of 37 consecutive patients who underwent DP-CAR were evaluated for the incidence of DGE in 23 patients (62 %) with left gastric artery (LGA)-resecting DP-CAR (conventional DP-CAR) compared ...
Sheppard Michael M Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK, - - 2014
A large, randomized, double-blind, Phase III core study demonstrated that pasireotide LAR was significantly superior to octreotide LAR at providing GH <2.5 μg/L and normalized IGF-1 after 12 months' treatment in patients with acromegaly. We report the efficacy and safety of pasireotide LAR and octreotide LAR after up to 26 months' treatment. Patients with ...
Arai Hirotaka H Department of Gastroenterology, Maebashi Red Cross Hospital, 3-21-36 Asahi-cho, Maebashi, Gunma 371-0014, - - 2014
Balloon-occluded transcatheter arterial chemoembolization (B-TACE) using a microballoon catheter was performed to administer miriplatin, and the early therapeutic efficacy and safety of the procedure were evaluated. Out of 158 patients who received miriplatin using B-TACE for hepatocellular carcinoma, 49 patients with a single lesion at either stage I or II ...
Sofos Stratos S SS From the Whiston Hospital, Liverpool, United - - 2014
Perioral facial burns have a high propensity to formation of microstomia and numerous prosthetic devices have been described that can be used postoperatively to address this problem. We introduce a novel device, the Whiston Buccal Prosthesis, which is used intraoperatively and in the early postoperative period and it acts as ...
Dietrich Pamela P *Department of Orthodontics and Paediatric Dentistry, University of Zurich, Switzerland - - 2014
Summary AIM: To assess the long-term success of maxillary fixed retainers, investigate their effect on gingival health, and analyse the survival rate after a mean period of 7 years (minimum 5 years) in retention. Forty one subjects were included in the study A clinical examination of the upper canine to ...
Picon Paulo D PD Centro de Pesquisa Clínica, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, - - 2014
Anemia is a common complication among chronic kidney disease patients on hemodialysis, occurring mostly due to erythropoietin deficiency. This randomized noninferiority trial sought to compare the efficacy and safety of a new epoetin formulation developed by Bio-Manguinhos, a biologics manufacturer affiliated with the Brazilian government, with those of a commercially ...
Inan Muharrem M *Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul †Department of Orthopedics and Traumatology, Muş State Hospital, Muş ‡Department of Orthopedics and Traumatology, Şirnak State Hospital, Şirnak, - - 2014
Knee flexion contracture in children with cerebral palsy (CP) is very common and functional impairment leads to a crouch gait. Correction of the knee flexion contracture and improvement of the gait pattern by supracondylar femoral extension osteotomy seems to be a more effective method than distal hamstring procedures in long-standing ...
González-Vacarezza Nicolás N Ministry of Public Health and National Institute of - - 2014
Objectives: The aim of this study was to evaluate the efficacy and safety of rituximab and tocilizumab compared with adalimumab, etanercept, and infliximab, in patients with rheumatoid arthritis not responding to first-line treatment, and to compare the efficacy and safety of rituximab versus tocilizumab in patients not responding to anti-tumor ...
Perrotta Laura L Cardioangiologisches Centrum Bethanien, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Wilhelm-Epstein-Str. 4, D-60431, Frankfurt am, - - 2014
Novel ablation devices for pulmonary vein isolation (PVI) need a careful evaluation of its efficacy and safety beyond clinical studies in a real world situation. The endoscopic ablation system (EAS) was recently approved for PVI in Europe. We sought to determine the safety, efficacy and learning curve effects of EAS-PVI ...
Lee Ji Hyun JH Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of - - 2014
We investigated and compared the clinical outcomes between biodegradable polymer biolimus-eluting stents (BES) and durable polymer everolimus-eluting stents (EES) in a single-center prospective registry. There is limited data regarding the safety and efficacy of the biodegradable BES compared to second-generation drug-eluting stents. From January 2010 to April 2012, a total ...
Torsello Giovanni G Department of Vascular Surgery, St. Franziskus Hospital and University Clinic of Muenster, Muenster, Germany. Electronic address: - - 2014
This study evaluated the 2-year safety and effectiveness of the European First-in-Human INNOVATION trial for the INCRAFT AAA Stent Graft system (Cordis Corp, Bridgewater, NJ), an ultra-low-profile device for the treatment of abdominal aortic aneurysms. From March 2010 to June 2011, the INNOVATION prospective multicenter trial involving six centers in ...
Khokhar S S Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical sciences, New Delhi, - - 2014
PurposeTo compare intraocular lens implantation using a motorized injector vs standard manual injector through a 2.2-mm clear corneal incision.MethodsPatients underwent standard phacoemulsification using a 2.2-mm clear corneal incision. Hydrophobic acrylic aspheric intraocular lens (Acrysof SN60WF intraocular lens (IOL)) was inserted using D cartridge with manual monarch injector or autosert motorized ...
Kawashima M M Department of Dermatology, Tokyo Women's Medical University, Tokyo, - - 2014
A topical fixed-dose clindamycin phosphate 1.2% and benzoyl peroxide 3% combination gel (CLNP/BPO 3%) is known to be effective and safe in Caucasians with acne. To evaluate the efficacy and safety of CLNP/BPO 3% topically applied once (-QD) or twice (-BID) daily versus CLNP-BID in Japanese acne patients. Eight hundred ...
Terman Samuel W SW 1Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI. 2Department of Neurology, University of Michigan Medical School, Ann Arbor, - - 2014
To compare short- and long-term neurologic outcomes in comatose survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia presenting with nonshockable versus shockable initial rhythms. Retrospective cohort study. Emergency department and ICU of an academic hospital. One hundred twenty-three consecutive post-out-of-hospital cardiac arrest adults (57 nonshockable rhythms, 66 shockable ...
Naccarelli Gerald V GV Heart and Vascular Institute, Penn State University College of Medicine, P. O. Box 850, MC H047, 500 University Drive, Room H1511, Hershey, PA, 17033, USA, - - 2014
To evaluate the safety of uninterrupted rivaroxaban, a novel oral anticoagulant that directly inhibits factor Xa, and a vitamin K antagonist (VKA) in eligible adult patients with nonvalvular AF (NVAF) who are scheduled for a catheter ablation. This is a prospective, randomized, open-label, active-controlled, global multicenter safety study of up ...
Rose John J Department of Surgery, University of California, San Diego2Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, - - 2014
In 2003, the Agency for Healthcare Research and Quality established Patient Safety Indicators (PSIs) to monitor preventable adverse events during hospitalizations. To evaluate the comparative safety of endovascular aneurysm repair (EVAR) vs open aneurysm repair (OAR) of abdominal aortic aneurysm by measuring PSIs associated with each procedure over time. Cases ...
Del Castillo Jimena J Pediatric Intensive Care Department. Hospital General Universitario Gregorio - - 2014
to analyze the mortality and neurological outcome factors of in-pediatric intensive care unit (PICU) cardiac arrest (CA) in a multicenter international study. prospective observational multicenter study in Latin-American countries, Spain, Portugal, and Italy. 250 children aged from 1 month to 18 years who suffered in-PICU CA were studied. Countries and ...
Straube Florian F Department of Cardiology and Internal Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich Municipal Hospital Group, Englschalkinger Str. 77, 81925 Munich, Germany - - 2014
Cryoballoon (CB) ablation with the second-generation cryoballoon (CBG2) seems to be more effective than its predecessor [first-generation cryoballoon (CBG1)], but phrenic nerve palsies were observed more frequently. The aim of this study was to compare the safety and efficacy of CBG1 and CBG2 in a substudy of the prospective multicentre, ...
Pati Debajyoti D Department of Design, College of Human Sciences, Texas Tech University, Lubbock (Dr Pati) and Center for Advanced Design Research & Evaluation, Dallas, Texas (Mr Harvey and Ms - - 2014
The objective of this study was to explore and identify physical design correlates of safety and efficiency in emergency department (ED) operations. This study adopted an exploratory, multimeasure approach to (1) examine the interactions between ED operations and physical design at 4 sites and (2) identify domains of physical design ...
Pang L - - 2014
Objective and Aim: The objective of the following study is to examine the effectiveness and safety of suspension laryngoscopy under intubation with propofol and remifentanil alone for vocal fold nodule (VFN) excision. Materials and Methods: A total of 40 patients were equally and randomly assigned to elective VFN excision using ...
Jarratt Michael - - 2014
Interdigital tinea pedis is one of the most common clinical presentations of dermatophytosis.<br /> This phase 3 study evaluated the safety and efficacy of luliconazole cream 1% in patients with tinea pedis.<br /> A total of 321 male and female patients aged &ge;12 years with tinea pedis and eligible for ...
Ghane Mohammad-Reza - - 2014
Background: Sedation in children remains a controversial issue in emergency departments (ED). Midazolam, as a benzodiazepine is widely used for procedural sedation among paediatrics. We compared the effectiveness and safety of two forms of midazolam prescription; intramuscular (IM) and intravenous (IV). Patients and Methods: A cohort study was conducted on ...
Dorweiler Bernhard B Department of Cardiothoracic and Vascular Surgery, University Medical Center, Mainz, - - 2014
Objective The aim of the study was to analyze long-term results of carotid endarterectomy (CEA) using bovine pericardium patch. Patients and Methods This study is a retrospective analysis of 274 consecutive cases (173 in CEA group and 101 patients in an internal control group of eversion endarterectomy [EEA]) operated between January 2005 ...
Kivitz Alan A Altoona Center for Clinical Research, Duncansville, - - 2014
Objective. The efficacy and safety of subcutaneous tocilizumab (TCZ-SC) vs placebo (PBO-SC) was evaluated in patients with RA with an inadequate response to DMARDs in the BREVACTA study. Methods. Patients (n=656) were randomized 2:1 to receive TCZ-SC 162 mg every other week (q2w) or PBO-SC q2w for 24 weeks; 20% ...
Schmidt A A Park-Hospital Leipzig, Center for Vascular Medicine, Leipzig, Germany - - - 2014
To provide additional clinical data regarding the safety and technical success of the OffRoad Re-Entry Catheter System (Boston Scientific, Natick, MA) for subintimal recanalization of chronic total occlusions (CTO) in the femoropopliteal arteries. A total of 92 patients (mean age 70.3 ± 10.6 years; 70% male) were enrolled in this ...
Armaghani Sheyan J SJ aDepartment of Orthopaedics, Vanderbilt Children's Hospital, Monroe Carell Jr. Children's Hospital, 4202 Doctors' Office Tower, 2200 Children's Way, Nashville, TN 37232, - - 2014
Study Design. Retrospective cohort analysis.Objective. Establish if drain levels exceed the minimum inhibitory concentrations (MIC) for common pathogens (MRSA, MSSA, P. acnes - 2 mcg/ml; S. epidermidis, E. faecalis - 4 mcg/ml). Evaluate the safety of topical vancomycin in pediatric patients undergoing spinal deformity surgery and determine if postoperative serum ...
Fuji T T Department of Orthopaedic Surgery, Japan Community Health care Organization Osaka Hospital, Osaka, - - 2014
Edoxaban, an oral direct factor Xa inhibitor, has proven antithrombotic efficacy. In a multicenter, phase II study, 264 total hip arthroplasty (THA) patients randomly received edoxaban 15 or 30 mg once daily or enoxaparin 2000IU (20-mg) twice daily for 11-14 days. Thromboembolic event incidences were 3.8% (3/78), 2.8% (2/72), and ...
Rassaf Tienush T University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225, Düsseldorf, - - 2014
Objective: To characterize the safety and efficacy of deep sedation (DS) as compared to general anaesthesia (GA) in percutaneous mitral valve repair (PMVR) using the MitraClip(®) system. Background: PMVR with the MitraClip(®) system has emerged as a therapeutic alternative to surgical valve repair in high-risk patients. The PMVR procedure is ...
Aryal Madan Raj MR Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania. Electronic address: - - 2014
Several studies have been conducted to study the efficacy and safety of rivaroxaban in the atrial fibrillation periprocedural ablation period with similar rates of thromboembolism and major bleeding risks compared with warfarin or dabigatran. We sought to systematically review this evidence using pooled data from multiple studies. Studies comparing rivaroxaban ...
Huang ZeYu Z Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, People's Republic of - - 2014
This study was aimed to determine the efficacy and safety of combined intravenous (IV) and topical application of tranexamic acid (TXA) in unilateral total knee arthroplasty (TKA) compared with the IV-TXA. One hundred eight-four patients were enrolled. Participants received either 3g of IV-TXA or 1.5g topical TXA combined with 1.5g ...
Lichtenstein Gary R GR *Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; and †Salix Pharmaceuticals Inc., Raleigh, - - 2014
Ulcerative colitis (UC), a chronic, relapsing, and remitting inflammatory bowel disease, requires long-term treatment to maintain remission. In this study, the long-term safety and tolerability of mesalamine granules (MG) therapy was evaluated in the maintenance of UC remission. Previous prospective studies evaluating different oral mesalamine formulations have not exceeded a ...
Gililland Jeremy M JM Department of Orthopaedic Surgery, University of Utah, Salt Lake City - - 2014
Barbed suture has been associated with improved closure efficiency and safety in TKA in prior studies. We performed a multicenter randomized controlled trial to determine the efficiency and safety of this technology in TKA. We prospectively randomized 411 patients undergoing primary TKA to either barbed running (n=191) or knotted interrupted ...
Torregrosa José-Vicente - - 2014
Lanthanum carbonate is a powerful phosphate binder that has shown efficacy and safety in clinical trials for hyperphosphataemia management, although there are few data in regular clinical practice. The study's objective was to evaluate, in regular clinical practice, its efficacy and safety in patients on dialysis. We retrospectively collected data ...
Anderson Maureen Ec - - 2014
Hand hygiene is considered one of the most important infection control measures in human healthcare settings, but there is little information available regarding hand hygiene frequency and technique used in veterinary clinics. The objectives of this study were to describe hand hygiene practices associated with routine appointments in companion animal ...
Caparas Jona J In the infection control department at New York Hospital Queens in Flushing, N.Y., Jona Caparas is the IV/PICC team coordinator and Jian Ping Hu and Hwei-San Hung are PICC nurses. Ms. Caparas is also the president of the Association for Vascular Access New York Metro - - 2014
Placing a central venous access device via the internal jugular or subclavian vein entails significant risks to both patient and healthcare worker. The purpose of this randomized, prospective study was to determine whether the accelerated Seldinger technique (AST) offers significant safety advantages over the modified Seldinger technique (MST) for peripherally ...
Larouche Alexandre A Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal, QC; ; Department of Urology, University of Montreal Health Centre, Montreal, - - 2014
We compare the complication rates and length of stay (LOS) of laser transurethral resection of the prostate (L-TURP) versus electrocautery transurethral resection of the prostate (E-TURP) in a population-based cohort. L-TURP has shown enhanced intraoperative safety and equivalent efficacy relative to E-TURP in several high volume centres. Relying on the ...
Sandić Marija Zivković - - 2014
The placement of fixed orthodontic appliances may lead to increased plaque accumulation and changes in subgingival microflora. The aim of this study was to examine the changes in frequency of subgingival microflora that occur after placement and removal of fixed orthodontic appliance using polymerase chain reaction (PCR). This study included ...
Turan Guluzar Arzu GA Guluzar Arzu Turan, MD, Department of Obstetrics and Gynecology, Sifa University Hospital, Izmir, - - 2014
Comparing locked and unlocked uterine closure techniques in terms of bleeding control and uterine incision healing. The patients undergoing cesarean section in Sifa University Hospital between May - October 2012 were accepted to this prospective controlled study. Primarily, safety was evaluated. The hemoglobin count (HC) and serum creatine kinase (CK) ...
Li Xiaoxin X Department of Ophthalmology, Peking University People's Hospital, Beijing, China. Electronic address: - - 2014
To assess the safety and efficacy of multiple injections of 0.5 and 2.0 mg conbercept using variable dosing regimens in patients with neovascular age-related macular degeneration (AMD). Randomized, double-masked, multicenter, controlled-dose, and interval-ranging phase 2 clinical trial divided into a 3-month loading phase followed by a maintenance phase. Patients with ...
Takeuchi Tsutomu T Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University , Tokyo , - - 2014
Objectives. To examine the long-term safety of intravenous (IV) abatacept treatment in Japanese patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX) or other conventional or biologic disease-modifying antirheumatic drugs. Methods. This Phase III, open-label, long-term study (NCT00484289) comprised Japanese patients with RA who had completed abatacept ...
Tang Yin Y West China Hospital, Urology, ChengDu, SiChuan, China ; - - 2014
BACKGROUND Evaluating the efficacy and safety of monopolar (M-TURP) and bipolar (B-TURP) transurethral resection of the prostate in benign prostatic hypertrophy (BPH) patients. METHODS Eligible randomized controlled trials (RCTs) were identified from electronic databases without language restrictions. Database search, quality assessment, and data extraction were independently performed. The primary postoperative ...
Zhang Kaile K sixth people's hospital, urology department, shanghai, China ; - - 2014
Introduction: Local steroid has been used as an adjuvant therapy to patients undergoing internal urethrotomy(IU) in treating urethral strictures. Whether this technique is effective and safe is still controversial. The aim of this study is to determine the efficacy and safety of local steroid applied in the procedure of internal ...
Wollenhaupt Jürgen J From the Schoen Klinik Hamburg, Hamburg, Germany; Healthpoint Medical Group, Tampa, Florida, USA; Seoul National University, Seoul, Republic of Korea; The University of Alabama at Birmingham, Birmingham, Alabama; Pfizer Inc., Groton, Connecticut; Pfizer Inc., Collegeville, Pennsylvania, USA; Pfizer Japan Inc., Tokyo, - - 2014
To describe the longterm safety and efficacy profile of tofacitinib in patients with moderate to severe active rheumatoid arthritis (RA). Data were pooled from 2 open-label studies (NCT00413699, NCT00661661) involving patients who had participated in qualifying phase I, II, or III index studies of tofacitinib. Safety data included over 60 ...
Jing Quan Q Department of Dentistry,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, - - 2014
Objective To evaluate the effectiveness and safety of a computer-controlled periodontal ligament (PDL) injection system to the local soft tissues as the primary technique in endodontic access to mandibular posterior teeth in patients with irreversible pulpitis.Methods A total of 162 Chinese patients who had been diagnosed with irreversible pulpitis in ...
Xu Chang-Peng CP Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of - - 2014
To examine the efficacy and safety of single-dose local infiltration of analgesia (LIA) for post-operative pain relief in total knee arthroplasty (TKA) patients. A systematic electronic literature search (up to Aug 2013) was conducted to identify the RCTs that address the efficacy and safety of single-dose LIA in the pain ...
Wilbring Manuel M Department of Cardiac Surgery, University Heart Center Dresden, Dresden, - - 2014
Infective native valve endocarditis (NVE) complicated by a preoperative neurological event still remains a surgical challenge. Particularly, great uncertainty exists with regard to the optimal timing of surgery. We call for a multidisciplinary team approach for individualized risk estimation and analysed our experience obtained over the past decade. Between 1997 ...
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