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Results 151 - 200 of 2097
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Sørensen Rikke Terp - - 2013
Objectives: Dysphagia occurs in approximately 51%-78% of patients with acute stroke. The incidence of pneumonia caused by aspiration in dysphagic patients increases both mortality and the need for hospitalization. The aim of this study was to investigate whether the incidence of aspiration pneumonia could be reduced in such patients by ...
Li Kai Nan - - 2013
STUDY DESIGN:: Prospective study evaluates the safety of one-stage multisegmental thoracolumbar percutaneous balloon vertebroplasty. OBJECTIVE:: To discuss the safety of one-stage multisegmental thoracolumbar percutaneous balloon vertebroplasty. SUMMARY OF BACKGROUND DATA:: The percutaneous balloon vertebroplasty is a minimally invasive surgery. It is mainly used in treatment with serious back pain caused ...
Kim Young Dae YD Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical School, Chosun University, Gwangju 501-717, South - - 2013
To evaluate the efficacy and safety of sodium hyaluronate solution (SH) in endoscopic submucosal dissection (ESD) of gastric neoplasms. A prospective multicenter randomized, double blind, controlled trial was designed and utilized in this study. A total of 76 patients with 5-20 mm sized gastric neoplasms were enrolled at three academic ...
Bryer Alan - - 2013
BACKGROUND: Stroke is an important cause of death and disability in sub-Saharan Africa. Thrombolysis with recombinant tissue plasminogen activator (tPA) is the only effective therapy for acute ischaemic stroke. Essential requirements for stroke thrombolysis include availability of CT scanning and arrival at hospital within 4.5 hours of symptom onset. However, ...
Kim James - - 2013
PURPOSE:: To retrospectively evaluate the safety and efficacy of an Ahmed glaucoma valve (AGV) modified with a polyethylene shell (M4) to reduce the fibrotic reaction around the drainage plate compared with the S2 and FP7 models in patients with glaucoma. METHODS:: The medical records of patients who underwent implantation of ...
Neuwirth Robert S - - 2013
STUDY OBJECTIVE: To explore the safety, feasibility, and effectiveness of silver nitrate-dextran paste delivered through the cervix as a simple and inexpensive endometrial ablation therapy for menorrhagia. DESIGN: Safety, feasibility, and effectiveness trials (Canadian Task Force classification II-3). SETTING: The trials were performed at the Whittington Hospital in London. PATIENTS: ...
Park Won W Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, Republic of Korea. - - 2013
To compare the pharmacokinetics (PK), safety and efficacy of innovator infliximab (INX) and CT-P13, a biosimilar to INX, in patients with active ankylosing spondylitis (AS). Phase 1 randomised, double-blind, multicentre, multinational, parallel-group study. Patients were randomised to receive 5 mg/kg of CT-P13 (n=125) or INX (n=125). Primary endpoints were area ...
Aikawa Takeshi - - 2013
OBJECTIVE: To describe diagnostic findings, complications, and long-term outcome of dogs with atlantoaxial instability (AAI) that had modified ventral stabilization with positively threaded profile pins and polymethylmethacrylate by 1 surgeon and to evaluate the potential prognostic indicators. STUDY DESIGN: Retrospective case series. ANIMALS: Dogs (n = 49) with AAI. METHODS: Medical records ...
Doizi Steeve - - 2013
PURPOSE: The use of a ureteral access sheath (UAS) during flexible retrograde intrarenal surgery (RIRS) has become increasingly popular. Our aim was to evaluate the accessibility of a new UAS device, allowing the transformation of the working guidewire into a safety guidewire. METHODS: A prospective, multicenter study was conducted between ...
Komatsu Tomohide - - 2013
OBJECTIVE: Few studies have reported factors that result in a better neurological outcome in patients with postcardiac arrest syndrome (PCAS) following return of spontaneous circulation (ROSC). We investigated the factors affecting neurological outcome in terms of both prehospital care and treatments after arrival at hospital in patients with PCAS. METHODS: ...
Dyer Erin - - 2013
Objective: To examine time delays and identify factors that affect wait times from index neurological event to carotid endarterectomy in patients with symptomatic carotid stenosis treated at a regional neurosurgical referral centre. Methods: We performed a retrospective audit over two years of all patients who underwent a carotid endarterectomy at ...
Näslund Jens-Ove - - 2013
For a deep geological repository for spent nuclear fuel planned in Sweden, the safety assessment covers up to 1 million years. Climate scenarios range from high-end global warming for the coming 100 000 years, through deep permafrost, to large ice sheets during glacial conditions. In contrast, in an existing repository for short-lived waste ...
Johnson Davin - - 2013
This study reviews differences in both ocular and systemic safety between intravitreal bevacizumab and ranibizumab in the setting of neovascular age-related macular degeneration. Serious adverse events associated with either bevacizumab or ranibizumab injections are generally rare. However, acute intraocular inflammation (AII) tends to occur more frequently following bevacizumab injection. Systemic ...
Kaji Akihiko - - 2013
To investigate the impact of bonded mandibular orthodontic retainers on local periodontal health. Two groups of subjects were recruited and designated Group F+, individuals who were provided with a fixed wire lingual retainer in the mandibular anterior area following orthodontic treatment and Group F-, individuals with no fixed wire and ...
Dahiya Pushpa - - 2013
To evaluate the efficacy of placentrex injection along with oral doxycycline against oral doxycycline in pelvic inflammatory diseases, a comparative study was undertaken among two groups of patients comprising 60 in each at Pt BD Sharma Postgraduate Institute of Medical Sciences, Rohtak during the period April 2010 to April 2012. ...
Namani Sadie - - 2013
OBJECTIVE: To prospectively analyze the prognostic factors for neurological complications of childhood bacterial meningitis. METHODS: This prospective study enrolled 77 children from 1 month until 16 years of age, treated for bacterial meningitis during the period of January 1, 2009 through December 31, 2010. 16 relevant predictors were chosen to ...
Watanabe Mamoru - - 2013
BACKGROUND:: Mesalazine preparations are widely used to treat mild to moderately severe ulcerative colitis (UC). We compared once-daily administration of oral mesalazine in patients with quiescent UC with the established 3-times-daily prescription, assessing the efficacy and safety of each method in maintaining remission for 52 weeks. METHODS:: This was a ...
Stoppe C - - 2013
BACKGROUND: /st>To date, only limited data exist about the use of xenon as an anaesthetic agent in patients undergoing cardiac surgery. The favourable cardio- and neuroprotective properties of xenon might attenuate postoperative complications, improve outcome, and reduce the incidence of delirium. Thus, the aims of this study were to investigate ...
Bartus Raymond T RT Ceregene, Inc., San Diego, CA, USA. - - 2013
In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced Parkinson disease (PD), of bilaterally administering the gene therapy vector AAV2-neurturin (CERE-120) to the putamen plus substantia nigra (SN, a relatively small structure ...
Fukuda Wakako - - 2013
Purpose: Management of patients with infective endocarditis complicated by neurological deficits is challenging. No clear management guidelines have been defined, and the timing of surgery remains controversial. The purpose of this study was to evaluate our management algorithm.Methods: Thirty-eight adult patients with left-sided infective endocarditis undergoing valve surgery were analyzed. ...
Li Yongkun - - 2013
In this study, we aimed to evaluate the safety and feasibility of simultaneous bilateral carotid artery stenting (BCAS) compared with staged BCAS in patients with bilateral atherosclerotic carotid stenosis (BCS). From January 2004 to March 2012, 68 patients who underwent BCAS were identified from the Nanjing Stroke Registry Program. Of ...
Chen Kuan-Chin J - - 2013
Background: Research has demonstrated equivalent patient safety outcomes for various cardiac procedures when the primary surgeon was a supervised trainee. However, cardiac surgery cases have become more complex, and the Canadian cardiac surgery education model has undergone some changes. We sought to compare patient safety and efficiency of aortic valve ...
Page Lawrence R - - 2013
The short-term clinical and microbiological effects of patient-applied subgingival root brushing were assessed on untreated deep human periodontal pockets. Assessments of plaque, bleeding on probing, probing depth, total cultivable subgingival counts, and cultivable counts and proportions of six putative periodontal pathogens were carried out at baseline and after 14 days ...
Akarsu Ayazo─člu Tulin - - 2013
Background: The ideal sedative agent for endoscopic procedures should allow a rapid modification ofthe sedation level and should not have any adverse effects. Aim: To evaluate and compare the efficacy, safety, cost and patient satisfaction of some propofol-based sedation regimens administered during colonoscopy. Material and Methods: One hundred twenty one ...
Kulkarni K - - 2013
Backgroud Cervical epidural anaesthesia (CEA) using local anesthetics (LA) is a well established technique for the surgeries in the neck, chest and upper arms. Recently ropivacaine is introduced with better safety profile. Objectives The aim was to observe the safety of Cervical epidural anaesthesia as an anaesthetic technique and to ...
Okachi Shotaro - - 2013
AIM: The usefulness and safety of endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) have been established recently, but no study has evaluated whether or not aging increases the risk of the procedure. In the present study, we aimed to assess the usefulness and safety of EBUS-TBNA in older patients. METHODS: The ...
Mills Daniel C - - 2013
Background: Most filler procedures in the United States are performed with hyaluronic acid (HA) derivatives. Artefill (Suneva Medical, Inc, San Diego, California), the only polymethylmethacrylate (PMMA)-enhanced dermal filler approved by the US Food and Drug Administration (FDA), has been well tolerated by patients for treatment of nasolabial folds and has ...
Huang Ming-Chao - - 2013
To estimate the safety and effectiveness of unidirectional knotless barbed suture compared to the traditional suture for repair of uterine wall defects through myomectomy via mini-laparotomy. This was a prospective clinical study performed by a single surgeon in a medical center. Sixty-eight women with symptomatic myoma were enrolled. Their uterine ...
Genovese Mark C - - 2013
OBJECTIVE: To assess the longterm safety and efficacy of tocilizumab (TCZ) in patients with moderate to severe rheumatoid arthritis (RA). METHODS: Patient data were from 5 randomized controlled TCZ trials (n = 4211), their open-label extension phases (n = 3512), and a drug interaction study (n = 23). All randomly ...
Agarwal Shvetank - - 2013
The aim of this prospective, randomized, double-blind, placebo controlled trial was to evaluate the safety and efficacy of continuous ropivacaine infusion of into the sternal wound. We planned to enroll 200 patients scheduled for various cardiac surgical procedures into the study. Patients, in a double-blind randomized fashion, were given either ...
Das L K - - 2013
Lymphoedema of extremities is a major clinical manifestation of lymphatic filariasis. Recurrent episodes of acute dermato-lymphangioadenitis (ADLA) in these patients lead to progression of the clinical condition. Studies have documented the effectiveness of regular limb hygiene in reduction in frequency and duration of ADLA. However, no data is available on ...
He Bo - - 2013
This study developed a human acellular nerve graft (hANG) as an alternative to autogenous nerve and reports on its safety and efficacy. There were two groups comprised of 72 patients that received digital nerve repair with hANG (test) and 81 that received conventional direct tension-free suture repair of the nerve ...
Coskun Isa - - 2013
BACKGROUND: A neurologic event (NE) after coronary artery bypass graft (CABG) surgery is a principal complication affecting morbidity and mortality. We investigated the risk factors predicting postoperative NEs and survival in patients with pre-existing NE undergoing CABG. METHODS: Between 2001 and 2012, 3137 patients underwent isolated primary CABG. The data ...
Rajeev Parameswaran - - 2013
BACKGROUND: Minimally invasive parathyroidectomy (MIP) is the choice of treatment in patients with sporadic adenomas localized on preoperative imaging. Currently there is no centre in the UK which performs this procedure under local anaesthesia. The aim of this study was to assess the efficacy and safety of MIP under local ...
Findlay Andrew - - 2013
Prophylactic mupirocin for peritoneal catheter exit sites reduces exit site infection (ESI) risk but engenders antibiotic resistance. We present early interim safety analysis of an open-label randomized study comparing polyhexamethylene biguanide (PHMB) and mupirocin. A total of 106 patients randomized to 53 in each group were followed up for a ...
Kakutani Kenichiro K Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuo-ku, Kobe, 650-0017, Japan. - - 2013
A retro-odontoid pseudotumor is usually a reactive fibrocartilaginous mass associated with atlantoaxial subluxation (AAS). However, a retro-odontoid pseudotumor not associated with AAS, which undergoes spontaneous regression following C1 laminoplasty, has been reported. The purpose of this study was to report surgical outcomes of C1 laminectomy for retro-odontoid pseudotumor without AAS. ...
Baygin O - - 2013
Objective: To evaluate the effect of chlorhexidine-thymol varnish alone, its combination with chlorhexidine-fluoride containing dentifrice and fluoride varnish on oral hygiene and caries prevention in orthodontic patients. Study design: Sixty patients, aged 12-18, with orthodontic fixed appliances were randomly assigned into three groups as follows: Group 1 (n=20): 1% chlorhexidine ...
Ramirez-Castaneda Juan - - 2013
Local chemodenervation with botulinum toxin (BoNT) injections to relax abnormally contracting muscles has been shown to be an effective and well-tolerated treatment in a variety of movement disorders and other neurological and non-neurological disorders. Despite almost 30 years of therapeutic use, there are only few studies of patients treated with ...
Gomes Bruno B Division of Orthopaedic Surgery, Department of Surgery, St Michael's Hospital, Room 800, 55 Queen Street East, Toronto, ON, M5C1R6, - - 2013
Press-fit acetabular component seating in hip resurfacing can be challenging as a strong interference fit is required. It has not been established whether reducing the acetabular underream minimizes incomplete component seating or leads to increased acetabular loosening. We examined (1) the incidence and natural history of postoperative interference gaps in ...
Yap Felix Y - - 2013
PURPOSE: The purpose of this study was to assess safety, efficacy, and clinical outcomes following transcatheter arterial embolization (TAE) of acute gastrointestinal (GI) bleeding. MATERIALS AND METHODS: Ninety-five patients (male:female ratio = 53:42, mean age 62 years) that underwent 95 TAEs for GI hemorrhage between 2002 and 2010 were retrospectively studied. Seventy-six of ...
Kimball Alexa B - - 2013
BACKGROUND: Etanercept is approved for the treatment of chronic moderate to severe plaque psoriasis in adults. OBJECTIVE: We sought to evaluate the long-term safety of etanercept in a real-world clinical setting. Assessment of etanercept efficacy was a secondary objective. METHODS: OBSERVE-5 is a 5-year observational safety registry initiated in May ...
Fishbane Steven - - 2013
Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent (ESA), is a potential therapy for anemia in patients with advanced chronic kidney disease. We conducted two randomized, controlled, open-label studies (EMERALD 1 and EMERALD 2) involving patients undergoing hemodialysis. Cardiovascular safety was evaluated by analysis of an adjudicated composite safety end point--death from ...
Jove Maurice - - 2013
Desirudin, administered 30 minutes before total hip arthroplasty is superior to enoxaparin in preventing proximal deep vein thrombosis (DVT) and pulmonary embolism (PE) with similar bleeding. The purpose of this study was to determine the safety of desirudin in patients undergoing elective total knee arthroplasty (TKA) when the first dose ...
Tanahashi Norio - - 2013
BACKGROUND: The overall analysis of the rivaroxaban versus warfarin in Japanese patients with atrial fibrillation (J-ROCKET AF) trial revealed that rivaroxaban was not inferior to warfarin with respect to the primary safety outcome. In addition, there was a strong trend for a reduction in the rate of stroke/systemic embolism with ...
Ong Loke Meng - - 2013
AIM: The objective of the study was to compare the efficacy and safety of oral paricalcitol with oral calcitriol for treating secondary hyperparathyroidism. METHODS: We conducted the first multicenter open-labelled parallel group randomised controlled trial in 66 patients on dialysis. Patients were randomized to paricalcitol or calcitriol at a 3:1 ...
Bellot Pablo - - 2013
BACKGROUND AND AIMS: Refractory ascites (RA) affects 10% of patients with advanced cirrhosis and ascites. Usual therapy includes large volume paracentesis, and in selected patients, a transjugular portosystemic shunt (TIPS). These therapies may be associated with increased morbidity: paracentesis may induce circulatory dysfunction and impair quality of life and TIPS ...
Papp K A - - 2013
BACKGROUND: Long-term safety evaluations of biologics are needed to inform patient management decisions. OBJECTIVES: To evaluate the safety of ustekinumab in patients with moderate-to-severe psoriasis treated for up to five years. PATIENTS AND METHODS: Safety data were pooled from four studies of ustekinumab for psoriasis. Rates of adverse events (AEs), ...
Jean-Baptiste E - - 2013
OBJECTIVES: To evaluate the prognostic value of cerebral border-zone infarctions (watershed infarctions) on the early postoperative outcomes of patients undergoing carotid endarterectomy (CEA) after acute ischemic stroke (AIS). METHODS: Sixty-six (66) patients with symptomatic carotid stenosis (SCS) that underwent ipsilateral CEA after AIS from January 2007 to March 2012 were ...
Russell Robert D - - 2013
Venous thromboembolism (VTE) is a common complication after total hip and total knee arthroplasty. Currently used methods of VTE prophylaxis after these procedures have important limitations, including parenteral administration, and unpredictable plasma levels requiring frequent monitoring and dose adjustment leading to decreased patient compliance with recommended guidelines. New oral anticoagulants ...
Al-Obeidan Saleh A - - 2013
To investigate the efficacy and safety of deep sclerectomy (DS) in Saudi patients with primary and secondary open-angle glaucoma (OAG). In this retrospective cohort study, a total of 194 eyes of 152 patients with OAG were consecutively enrolled to undergo DS with Mitomycin-C (MMC) at King Abdulaziz University Hospital, Jeddah, ...
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