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Martins Raphaël P RP CHU Rennes, Service de Cardiologie et Maladies Vasculaires, Rennes, F-35000, France; Université de Rennes 1, LTSI, Rennes, F-35000, France; INSERM, U1099, Rennes, F-35000, France; INSERM, CIC-IT 804, Rennes, F-35000, France. Electronic address: - - 2014
Compared with the first-generation Arctic Front (ARC-CB), the new Arctic Front Advance (ARC-Adv-CB) cryoballoon increases efficient balloon-tissue contact surface during freezing, which may increase phrenic nerve (PN) palsy (PNP) incidence. To evaluate the safety and efficacy of paroxysmal atrial fibrillation (AF) ablation with the ARC-Adv-CB, and the merits of a ...
Shamban Ava A ATS Clinical Research, Santa Monica, - - 2014
Background: Due to advances in detection and treatment, approximately 70 percent of cancer patients are living more than five years after diagnosis. Research indicates that appearance worries are of great concern to cancer survivors impacting their quality of life. This is the first Phase IV investigator-initiated study to investigate the ...
Shah Sanjay S Senior Demonstrator, Department of Pharmacology, Government Medical College , Jammu and Kashmir, India - - 2014
Aim: To compare the safety and efficacy of Enoxaparin (EX) and Fondaparinux (FD) in patients with Unstable Coronary Artery Disease (UCAD). Materials and Methods: A prospective, open label, randomized comparative study was designed to study the comparative efficacy and safety of EX and FD in UCAD patients. Recovery, recurrence, major ...
Alió Jorge L - - 2014
To compare the efficacy and safety outcomes of bimanual microincision cataract surgery (MICS) versus 2.2-mm coaxial phacoemulsification assisted by Femtosecond LenSx (Alcon-LenSx Inc., Aliso Viejo, CA). This prospective, randomized, observational, comparative case series comprised 50 cataractous eyes of 50 patients receiving femtosecond laser refractive lens surgery followed by a bimanual ...
Alió Jorge L - - 2014
To compare the efficacy and safety outcomes of bimanual microincision cataract surgery (MICS) versus 2.2-mm coaxial phacoemulsification assisted by Femtosecond LenSx (Alcon-LenSx Inc., Aliso Viejo, CA). This prospective, randomized, observational, comparative case series comprised 50 cataractous eyes of 50 patients receiving femtosecond laser refractive lens surgery followed by a bimanual ...
Kasel Albert Markus AM Klinik für Kardiologie und Intensivmedizin, Klinikum Bogenhausen Munich, Germany ; Deutsches Herzzentrum, Technische Universität Munich, - - 2014
Few data is available comparing Edwards SAPIEN XT - SXT (Edwards Lifesciences, Irvine, California) with Medtronic CoreValve - CoV (Medtronic Inc., Minneapolis, Minnesota) in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). We selected consecutive patients undergoing transfemoral TAVR with SXT or CoV at our Institution. Main ...
Alosh Hassan H Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia, - - 2013
The number of patients requiring bilateral total knee arthroplasty (TKA) is expected to grow rapidly. While some trials have compared staged with simultaneous TKA, no literature characterizes the subset of staged TKA patients who cancel their second surgery. In this study, we report on the safety and utility of a ...
Wiebe Jens - - 2013
Objective: To evaluate the safety of percutaneous left atrial appendage (LAA) closure with the Amplatzer Cardiac Plug (ACP) in patients with non-valvular atrial fibrillation (AF) who are not eligible for oral anticoagulation with warfarin. Background: Anticoagulation is the treatment of choice for prevention of strokes in patients with AF, but ...
Vakil Kairav - - 2013
Background: The MitraClip® system is a newer percutaneous device that has shown promising results but data on its safety and efficacy in low and high surgical risk populations continues to evolve. We performed a systematic review of the published studies reporting the safety and efficacy of MitraClip® implantation for treatment ...
Knerr Meike - - 2013
Objective. The aim of this study was to evaluate the safety and efficacy of the GORE® Septal Occluder (GSO) at 1-, 6- and 12-month follow-up in patients with a clinical indication for patent foramen ovale (PFO) closure. Background. Limited data are available regarding the safety and efficacy of the GSO ...
Rizzoli Rene - - 2013
To investigate the efficacy and safety of oral fixed-dose combination strontium ranelate 2 g/vitamin D3 1,000 IU daily vs. strontium ranelate 2 g daily for correction of vitamin D insufficiency in osteoporosis. A 6-month international, randomized, double-blind, parallel-group, phase 3 study. 518 men and postmenopausal women aged ≥50 years with ...
Barahona-Guzmán Nayide - - 2013
To assess the feasibility and effectiveness of the International Nosocomial Infection Control Consortium (INICC) multidimensional hand hygiene (HH) approach in Colombia, and analyze predictors of poor HH compliance. An observational, prospective, interventional, before-and-after study was conducted from May 2003 through September 2010 in 10 intensive care units (ICUs) of six ...
Fritsch Gerhard - - 2013
Research suggests that the addition of dexmedetomidine to local anesthetics can prolong peripheral nerve blocks; however, clinical safety data are limited, and interscalene blocks have not been studied. The present study was designed to test the hypothesis that dexmedetomidine added to ropivacaine would safely enhance the duration of analgesia without ...
Fernandez Sierra M Amelia - - 2013
This study aims to estimate the incidence of adverse events (AEs) and avoidable AE in four hospital services before and after applying strategies for patient safety. Retrospective study of two cohorts (2006 and 2009). General Surgery, Internal Medicine, Intensive Care Unit and Oncology services. A sample of 365 patients (2006) ...
Ruff Christian T CT Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Four new oral anticoagulants compare favourably with warfarin for stroke prevention in patients with atrial fibrillation; however, the balance between efficacy and safety in subgroups needs better definition. We aimed to assess the relative benefit of new oral anticoagulants in key subgroups, and the effects on important secondary outcomes. We ...
Selmon Matthew R - - 2013
Purpose : To evaluate the safety and effectiveness of the optical coherence tomography-guided Ocelot catheter to cross femoropopliteal chronic total occlusions (CTOs). Methods : The CONNECT II study was a prospective, multicenter, non-randomized single-arm study of the safety and effectiveness of the Ocelot catheter in CTO crossing. Key inclusion criteria ...
Kulkarni A G AG Department of Orthopaedics, Bombay Hospital and Medical Research Centre, Mumbai, - - 2013
A 48-year-old woman presented with severe bilateral leg pain, urinary incontinence, and paraparesis following vertebroplasty in another hospital 15 days earlier. Computed tomography and magnetic resonance imaging showed blocks of epidural and intradural cement from T12 to L1 with neurological compression. She underwent corpectomy of L1 and removal of extradural ...
Gültekin Salih Sinan SS Department of Nuclear Medicine, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, - - 2013
Objective: Most of the radiopharmaceuticals used in nuclear medicine are excreted via the urinary system. This study evaluated the importance of a reduction in bladder radioactivity for radiation safety. Methods: The study group of 135 patients underwent several organ scintigraphies [40/135; thyroid scintigraphy (TS), 30/135; whole body bone scintigraphy (WBS), ...
Selig Christoph - - 2013
Predicting the neurological outcome after cardiopulmonary resuscitation (CPR) is extremely difficult. We tested the hypothesis whether monitoring of bispectral index (BIS) and suppression ratio (SR) could serve as an early prognostic indicator of neurological outcomes after CPR. Cerebral monitoring (BIS, SR) was started as soon as possible after initiation of ...
Naess H - - 2013
To compare short-term outcome and long-term mortality in old and younger patients with ischemic stroke. We hypothesized that short-term outcomes in patients ≥80 and <80 years with no neurological worsening are similar. The National Institute of Health Stroke Scale (NIHSS) was used to assess stroke severity. Short-term outcome was determined by ...
Youssof Sarah - - 2013
Introduction: Despite multiple studies reporting marked benefit of botulinum toxin (BTX) for treatment of cricopharyngeal dysphagia, little is known about its safety for this indication. We examined the safety of cricopharyngeal BTX for dysphagia in oculopharyngeal muscular dystrophy (OPMD). Methods: We reviewed records of patients with OPMD who received cricopharyngeal ...
Mao Wei - - 2013
Screening esophagogastroduodenoscopy (SEGD) is recommended in liver cirrhotic patients while endoscopic variceal ligation (EVL) is used as secondary prophylaxis for esophageal varices. Although sedation is commonly used in gastrointestinal endoscopy, the safety of sedation is unclear for SEGD and EVL in cirrhotic patients. This study was aimed to investigate the ...
Hummel John - - 2013
Persistent and long-standing persistent atrial fibrillation (AF) often requires extensive and/or repeat radiofrequency ablation (RFA) procedures. The Tailored Treatment of Persistent Atrial Fibrillation (TTOP-AF) study assessed the effectiveness and safety of the Phased RF system in a randomized, controlled comparison of medical therapy against phased RFA for management of persistent ...
Mazzoleni S - - 2013
The aim was to compare the efficacy of the electric versus the manual toothbrush in terms of the oral hygiene achieved by patients wearing rapid palatal expanders (RPEs). Forty patients were randomly divided into two groups; one equipped with a manual toothbrush (Group A), the other with an electric toothbrush ...
Baram Ilan - - 2013
To evaluate the initial safety and effectiveness of the intrauterine ball (IUB), a copper intrauterine device that, upon insertion in the uterus, takes a three-dimensional spherical form. Fifteen women were followed for 1 year, with follow-up visits at 1, 3, 6, 9 and 12 months. The physician reported that all ...
Wang Bingsong - - 2013
To evaluate the efficacy and safety of intracameral triamcinolone acetonide in phacotrabeculectomy. Beijing Shijitan Hospital, Capital University of Medical Sciences, Beijing, China. Prospective randomized controlled trial. Patients having combined trabeculectomy and cataract surgery were enrolled from March 2010 through January 2012. The patients were randomly divided into 4 groups. At ...
Bazan Hernan A - - 2013
Increasing evidence supports that urgent carotid endarterectomy (CEA), defined as CEA during the index hospitalization, may be undertaken in select patients with acute carotid-related neurological symptoms to prevent recurrent ischemic events. We aimed to determine the effect of a stroke/vascular neurology service on the volume of urgent CEAs performed and ...
Zhou Jian-Hui - - 2013
A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis (PD) solutions. Some researchers believe that 6 L/d is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy ...
Corriere Matthew A - - 2013
Carotid revascularization, including carotid endarterectomy (CEA) and carotid angioplasty and stenting (CAS), is performed for stroke risk reduction but may also impact cognitive function. Cognitive outcomes observed following carotid revascularization have been inconsistent, and mechanistic relationships with procedural factors are poorly understood. To further explore associations between carotid revascularization and ...
Boulanger Henri - - 2013
<title>ABSTRACT</title> <bold><italic>Purpose:</italic></bold> Our aim was to evaluate the safety and effectiveness of the IRIS® bandage (Nephrokit®) on post-puncture bleeding compared to conventional manual compression. <bold><italic>Methods:</italic></bold> Sixty-four patients, hemodialyzed with an arteriovenous fistula, were enrolled in a 3-week prospective study. Conventional manual compression was used during the first week, the IRIS® ...
Liew A - - 2013
Extended-duration thromboprophylaxis with low molecular weight heparin (LMWH) reduces the frequency of symptomatic venous thromboembolism (VTE) among patients undergoing total hip or knee arthroplasty (1). Recent trials have evaluated the efficacy and safety of the new oral anticoagulants (NOACs), dabigatran etexilate, rivaroxaban and apixaban, for VTE prevention in patients undergoing ...
Lee Tae Rim - - 2013
Several methods have been proposed to evaluate neurological outcome in out-of-hospital cardiac arrest (OHCA) patients. Blood lactate has been recognized as a reliable prognostic marker for trauma, sepsis, or cardiac arrest. The objective of this study was to examine the association between initial lactate level or lactate clearance and neurologic ...
Bae Dong Sik DS Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, - - 2013
A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the antiadhesive effect and safety of HA-CMC membrane in thyroidectomy for papillary thyroid cancer. One hundred sixty-two patients who underwent thyroidectomy were prospectively randomized. In the study group ...
Volovat Constantin C Centrul de Oncologie Medicala, Iasi, - - 2013
Recombinant granulocyte colony-stimulating factors (G-CSFs) reduce the incidence and duration of chemotherapy-induced neutropenia and febrile neutropenia when given as adjunct therapy to patients receiving myelosuppressive chemotherapy. Balugrastim is a long-acting G-CSF composed of a genetic fusion between recombinant human serum albumin and G-CSF. We compared the efficacy and safety of ...
Palomba Stefano - - 2013
To compare single-incision mini-slings (SIMS) and retropubic tension free vaginal tape (r-TVT) in terms of the long-term efficacy and safety for the treatment of female stress (SUI) or mixed urinary incontinence (MUI). Prospective multicenter cohort trial (registration number NCT00751088). Canadian Task Force - II SETTINGS: Department of Obstetrics and Gynecology, ...
Lin David M - - 2013
The use of erythropoietin (EPO) and intravenous (IV) iron as bloodless therapeutic modalities is being explored in the current era of restrictive transfusion strategies and perioperative blood management. It is unclear, however, whether the evidence in the literature supports their safety and efficacy in reducing perioperative red cell transfusions. Adhering ...
Gempt Jens - - 2013
Object Brain metastases occur in 10% to 40% of patients harboring cancer. In cases of neurosurgical metastasis resection, all postoperative neurological deterioration should be avoided. Reasons for postoperative deficits can be direct tissue damage due to resection, hemorrhage, venous congestive infarcts, or arterial ischemic events leading to tissue infarction. The ...
Sabbatani Paolo - - 2013
For several years, the electrical external cardioversion (ECV) has entered into clinical practice without assistance of anesthesiology team. The aim of this study was to evaluate the efficacy and safety of sedation with midazolam in patients undergoing electrical cardioversion of atrial fibrillation (AF) by means of the evaluation of capnometry ...
Fukuyo Shunsuke - - 2013
Objective. To evaluate the safety and efficacy of reducing the duration of infliximab infusion for rheumatoid arthritis (RA) treatment. Methods. The first 6 infliximab infusions were each administered over a 2-h period. If no adverse reaction was observed, infusion times were shortened to 1 h starting with the seventh infusion ...
Franceschi Frédéric - - 2013
-Right phrenic nerve palsy (PNP) is the most frequent complication of cryoballoon (CB) ablation. Diaphragmatic electromyography (EMG) can predict PNP with a comfortable safety margin. Our goal was to evaluate the feasibility, efficacy and safety of EMG-guided phrenic nerve (PN) monitoring using a novel hepatic vein approach for prevention of ...
Thomassen O - - 2013
Safety checklists have become an established safety tool in medicine. Despite studies showing decreased mortality and complications, the effects and feasibility of checklists have been questioned. This systematic review summarises the medical literature aiming to show the effects of safety checklists with a number of outcomes. The Preferred Reporting Items ...
Nicolosi Liliana Noemí - - 2013
Ventilator-associated pneumonia is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery outcomes. To determine the effect of tooth-brushing plus 0.12% chlorhexidine gluconate oral rinse in preventing of ventilator-associated pneumonia after cardiovascular surgery. In a quasi-experimental study patients undergoing heart surgery were enrolled on a ...
Bykerk V P - - 2013
To report the long-term safety data of certolizumab pegol (CZP) in rheumatoid arthritis (RA) accumulated as of 30 November 2011. Data from 10 completed randomised controlled trials (RCT) of CZP in RA and several open-label extensions (OLE) were pooled across all doses. Reported adverse events (AE) occurred between the first ...
Yılmaz Metin - - 2013
Objective: The objective of our study is to analyze whether low intraoperative hematocrit levels have an effect upon postoperative neurological events.Methods: Our study included 140 patients who underwent isolated coronary bypass under cardiopulmonary bypass between 2009 and 2012. The main group of the study was 70 patients with intraoperative hematocrit ...
Capoccia Laura - - 2013
The location of the carotid bifurcation and a very distal extension of internal carotid atherosclerotic disease may challenge vascular surgeons performing carotid endarterectomy (CEA) by increasing technical difficulty and possibly the incidence of cranial nerve damage or palsies. The objective of the present study is to report on the safety ...
Paul C - - 2013
Limited data exist on transitioning psoriasis patients from conventional systemic agents to biologics. The TRANSIT study aimed to assess the efficacy and safety of two methotrexate-to-ustekinumab transition strategies. Patients with moderate-to-severe psoriasis and inadequate methotrexate response were randomized 1:1 to initiate ustekinumab with immediate (arm 1) or 4-week gradual (arm ...
Schwindling Franz Sebastian - - 2013
The purpose of this study was to compare plaque adhesion, tissue reaction, and technical complications for complete dentures based on visible light-cured resin (VLCR) or on conventional poly(methyl methacrylate) (PMMA). A stratified randomized cohort study was designed with 52 patients treated with a complete denture in the maxilla (n = 28), the ...
Taber David J - - 2013
Background/Aims: There are no published studies assessing the safety and efficacy of thiazides as antihypertensives in kidney transplantation (KTX). Methods: This was a longitudinal retrospective cohort study conducted in adult KTX recipients. Patients were grouped based on receiving thiazides following KTX. Safety and efficacy comparisons were made between thiazide recipients ...
Goto Yoshikazu - - 2013
Few clinical trials have provided evidence that epinephrine administration after out-of-hospital cardiac arrest (OHCA) improves long-term survival. Here we determined whether prehospital epinephrine administration would improve 1-month survival in OHCA patients. We analyzed the data of 209,577 OHCA patients; the data were prospectively collected in a nationwide Utstein-style Japanese database ...
Vardi Moshe - - 2013
The efficacy and safety of primary stenting for superficial femoral artery (SFA) disease have been benchmarked against historically-derived performance goals. However, contemporary evidence evaluating SFA stenting is accumulating. The objective of this systematic review and meta-analysis was to quantitatively assess outcomes after primary SFA stenting with nitinol stents in contemporary ...
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