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Results 51 - 100 of 2038
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Gempt Jens - - 2013
Object Brain metastases occur in 10% to 40% of patients harboring cancer. In cases of neurosurgical metastasis resection, all postoperative neurological deterioration should be avoided. Reasons for postoperative deficits can be direct tissue damage due to resection, hemorrhage, venous congestive infarcts, or arterial ischemic events leading to tissue infarction. The ...
Sabbatani Paolo - - 2013
For several years, the electrical external cardioversion (ECV) has entered into clinical practice without assistance of anesthesiology team. The aim of this study was to evaluate the efficacy and safety of sedation with midazolam in patients undergoing electrical cardioversion of atrial fibrillation (AF) by means of the evaluation of capnometry ...
Fukuyo Shunsuke - - 2013
Objective. To evaluate the safety and efficacy of reducing the duration of infliximab infusion for rheumatoid arthritis (RA) treatment. Methods. The first 6 infliximab infusions were each administered over a 2-h period. If no adverse reaction was observed, infusion times were shortened to 1 h starting with the seventh infusion ...
Franceschi Frédéric - - 2013
-Right phrenic nerve palsy (PNP) is the most frequent complication of cryoballoon (CB) ablation. Diaphragmatic electromyography (EMG) can predict PNP with a comfortable safety margin. Our goal was to evaluate the feasibility, efficacy and safety of EMG-guided phrenic nerve (PN) monitoring using a novel hepatic vein approach for prevention of ...
Thomassen O - - 2013
Safety checklists have become an established safety tool in medicine. Despite studies showing decreased mortality and complications, the effects and feasibility of checklists have been questioned. This systematic review summarises the medical literature aiming to show the effects of safety checklists with a number of outcomes. The Preferred Reporting Items ...
Nicolosi Liliana Noemí - - 2013
Ventilator-associated pneumonia is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery outcomes. To determine the effect of tooth-brushing plus 0.12% chlorhexidine gluconate oral rinse in preventing of ventilator-associated pneumonia after cardiovascular surgery. In a quasi-experimental study patients undergoing heart surgery were enrolled on a ...
Bykerk V P - - 2013
To report the long-term safety data of certolizumab pegol (CZP) in rheumatoid arthritis (RA) accumulated as of 30 November 2011. Data from 10 completed randomised controlled trials (RCT) of CZP in RA and several open-label extensions (OLE) were pooled across all doses. Reported adverse events (AE) occurred between the first ...
Yılmaz Metin - - 2013
Objective: The objective of our study is to analyze whether low intraoperative hematocrit levels have an effect upon postoperative neurological events.Methods: Our study included 140 patients who underwent isolated coronary bypass under cardiopulmonary bypass between 2009 and 2012. The main group of the study was 70 patients with intraoperative hematocrit ...
Capoccia Laura - - 2013
The location of the carotid bifurcation and a very distal extension of internal carotid atherosclerotic disease may challenge vascular surgeons performing carotid endarterectomy (CEA) by increasing technical difficulty and possibly the incidence of cranial nerve damage or palsies. The objective of the present study is to report on the safety ...
Paul C - - 2013
Limited data exist on transitioning psoriasis patients from conventional systemic agents to biologics. The TRANSIT study aimed to assess the efficacy and safety of two methotrexate-to-ustekinumab transition strategies. Patients with moderate-to-severe psoriasis and inadequate methotrexate response were randomized 1:1 to initiate ustekinumab with immediate (arm 1) or 4-week gradual (arm ...
Schwindling Franz Sebastian - - 2013
The purpose of this study was to compare plaque adhesion, tissue reaction, and technical complications for complete dentures based on visible light-cured resin (VLCR) or on conventional poly(methyl methacrylate) (PMMA). A stratified randomized cohort study was designed with 52 patients treated with a complete denture in the maxilla (n = 28), the ...
Taber David J - - 2013
Background/Aims: There are no published studies assessing the safety and efficacy of thiazides as antihypertensives in kidney transplantation (KTX). Methods: This was a longitudinal retrospective cohort study conducted in adult KTX recipients. Patients were grouped based on receiving thiazides following KTX. Safety and efficacy comparisons were made between thiazide recipients ...
Goto Yoshikazu - - 2013
Few clinical trials have provided evidence that epinephrine administration after out-of-hospital cardiac arrest (OHCA) improves long-term survival. Here we determined whether prehospital epinephrine administration would improve 1-month survival in OHCA patients. We analyzed the data of 209,577 OHCA patients; the data were prospectively collected in a nationwide Utstein-style Japanese database ...
Vardi Moshe - - 2013
The efficacy and safety of primary stenting for superficial femoral artery (SFA) disease have been benchmarked against historically-derived performance goals. However, contemporary evidence evaluating SFA stenting is accumulating. The objective of this systematic review and meta-analysis was to quantitatively assess outcomes after primary SFA stenting with nitinol stents in contemporary ...
Tong Kenneth - - 2013
Adverse events (AEs) of ischemic colitis (IC) and complications of constipation (CoC) associated with alosetron are rare and have been adjudicated during the first 5.5 years of the risk management program (RMP); however, changes in incidence rates relative to reductions in AE reports and increases in alosetron prescriptions over the ...
Brown Timothy S - - 2013
Total knee arthroplasty (TKA) is one of the most common orthopedic procedures in the United States. The number of TKAs is expected to rise significantly over the next 2 decades. One of the most common complications after TKA is venous thromboembolism (VTE), which is potentially fatal. The incidence of VTE ...
Wood Robin - - 2013
Background: Safety and efficacy of the protease inhibitor fosamprenavir (FPV) ± ritonavir (r) was evaluated in 3 pivotal 48-week phase III studies. A follow-on study provides long-term data on FPV-based regimens. Methods: International, multicenter, uncontrolled open-label study APV30005 provided FPV as part of combination therapy to HIV-1-infected patients aged ≥13 ...
Mills Anthony M AM Anthony Mills MD Inc, Los Angeles, - - 2013
Due to ongoing neuropsychiatric adverse events in some efavirenz (EFV)-treated patients, a switch to an alternative non-nucleoside reverse transcriptase inhibitor may be considered. Rilpivirine (RPV) has been coformulated as a single-tablet regimen (STR) with emtricitabine/tenofovir disoproxil fumarate (FTC/TDF), and the components have demonstrated noninferior efficacy to EFV+FTC/TDF, good tolerability profile, ...
Shurrab Mohammed - - 2013
The safety and efficacy of dabigatran in the periprocedural period for patients undergoing atrial fibrillation ablation is not well established. We conducted a meta-analysis of the periprocedural use of dabigatran vs warfarin (with or without heparin bridging). A literature search was performed using multiple databases. Outcomes were (1) major bleeding; ...
Li Hulin - - 2013
To determine the feasibility and safety of percutaneous nephrolithotomy (PCNL) in treating upper urinary calculi under local infiltration anesthesia. A series of 2000 patients with upper urinary calculi underwent PCNL under local infiltration anesthesia. Of the 2000 patients, 536 had upper ureteral calculi, 805 patients had pelvic calculi, and 659 ...
Ogata Atsushi - - 2013
Objective. To evaluate the efficacious noninferiority of subcutaneous tocilizumab injection (TCZ-SC) monotherapy to intravenous TCZ infusion (TCZ-IV) monotherapy in Japanese patients with rheumatoid arthritis (RA) with an inadequate response to synthetic and/or biologic DMARDs. Methods. This study had a double-blind, double-dummy, parallel-group, comparative phase 3 design. Patients were randomized to ...
Meincke Felix - - 2013
Aims: The WATCHMAN® device was proven non-inferior to oral anticoagulation (OAT). However, periprocedural risks and uncertainty regarding patients with absolute contraindication for OAT limit the overall utilisation of this approach. We investigated the periprocedural safety of dual platelet inhibition and primary utilisation of larger device diameters in order to minimise ...
Sparks Eric A - - 2013
The Surgical Safety Checklist (SSC) has been introduced as an effective tool for reducing perioperative mortality and complications. Although reported completion rates are high, objective compliance is not well defined. The purpose of this retrospective analysis is to determine SSC compliance as measured by accuracy and completion, and factors that ...
Vichinsky Elliott - - 2013
We report a prospective, randomized, Phase II study of deferasirox and deferoxamine (DFO) in sickle cell disease (SCD) patients with transfusional iron overload, with all patients continuing on deferasirox after 24 weeks, for up to 2 years. The primary objective was to evaluate deferasirox safety compared with DFO; long-term efficacy ...
Visoiu Mihaela - - 2013
Different transversus abdominis plane blocks techniques cause variations in postoperative analgesia characteristics. We report the use of unilateral quadratus lumborum catheter for analgesia following colostomy closure. The catheter was placed under direct ultrasound visualization and had good outcomes: low pain scores and minimal use of rescue analgesic medication. No complications ...
Bergan Eduardo H - - 2013
To evaluate the effects of an oral health protocol on the incidence of postoperative pneumonia in patients submitted to coronary artery bypass grafting and to valve surgery. All patients admitted to a public cardiac surgery hospital were examined by a dentist and had a thorough dentistry anamnesis and an intraoral ...
Ozaki Makoto - - 2013
We evaluated the safety and efficacy of long-term administration of dexmedetomidine in patients in the intensive care unit (ICU). Primary endpoint was the incidence of hypotension, hypertension, and bradycardia. Secondary endpoints were withdrawal symptoms, rebound effects, the duration of sedation with Richmond Agitation-Sedation Scale (RASS) ≤ 0 relative to the total infusion ...
Lancelevee Julien - - 2013
This study compares the neurologic evolution and number of restenoses between 2 groups of patients who underwent internal carotid endarterectomy with patch angioplasty (CEP): one group with systematic intraoperative completion arteriography (CA) and another group without. This monocentric retrospective study was performed from January 2000 to December 2008 on 559 ...
Shehabi Yahya - - 2013
To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. Pilot prospective, multicenter, randomized, controlled trial. Six ICUs. Critically ill adults mechanically ventilated for greater than 24 hours. Patients randomized to early goal-directed sedation received a dexmedetomidine-based algorithm targeted to light sedation (Richmond Agitation Sedation ...
Birnbach D J - - 2013
This study investigated the impact of a fresh scent on the rate of hand hygiene compliance (HHC) among novice healthcare providers. In all, 165 participants examined a standardized patient with one sample exposed to fresh scent (N = 79) and the other exposed to the standard environment (N = 86). Hand hygiene behaviours were ...
Grossestreuer Anne V - - 2013
Therapeutic hypothermia (TH) has been shown to improve outcomes in comatose post-cardiac arrest syndrome (PCAS) patients. It is unclear how long it takes these patients to regain neurologic responsiveness post-arrest. We sought to determine the duration to post-arrest awakening and factors associated with times to such responsiveness. We performed a ...
Ganga Harsha V - - 2013
Therapeutic Hypothermia (TH) has become a standard of care in improving neurological outcomes in cardiac arrest (CA) survivors. Previous studies have defined severe acidemia as plasma pH<7.20. We investigated the influence of severe acidemia at the time of initiation of TH on neurological outcome in CA survivors. A retrospective analysis ...
Steinberg Benjamin A - - 2013
Dabigatran is approved for prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF). The safety and effectiveness of periprocedural dabigatran in ablation for AF are unknown. We performed a meta-analysis of all studies comparing periprocedural dabigatran with warfarin for anticoagulation in AF ablation. Studies of >100 ...
Aichmair Alexander - - 2013
Retrospective Case SeriesOBJECTIVE: To evaluate the proportional trend over time of neurological deficits after lateral lumbar interbody fusion (LLIF) at single institution.SUMMARY OF BACKGROUND DATA: Since lumbar nerve roots converge to run as the lumbar plexus within or less frequently underneath the posterior part of the psoas muscle, they are ...
Schwindt Arne - - 2013
Aims: The aim of the study was to determine the safety, efficacy and feasibility of a new chronic total occlusion (CTO) device using optical coherence tomography (OCT) technology, the Ocelot catheter (Avinger, Inc., Redwood City, CA, USA), for crossing of SFA CTOs following guidewire failure. Methods and results: Prospective, multicentre, ...
Czyż M - - 2013
The aim of the study was to assess the safety and effectiveness of stereotactic brain tumour biopsy (STx biopsy) guided by low-field intraoperative magnetic resonance imaging (iMRI) in comparison with its frameless classic analogue based on a prospective randomized trial. A pilot group of 42 brain tumour patients was prospectively ...
Shaw Monica - - 2013
: Gastrointestinal recovery is a critical milestone after bowel resection with postoperative ileus resulting in increased risk of complications and prolonged hospitalization. : The aim of this study is to evaluate the efficacy and safety of ulimorelin, a ghrelin receptor agonist given postoperatively in 2 identically designed phase 3 studies ...
Mulligan Patrick P Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, United States of - - 2013
Subdural hematoma (SDH) is a common disease entity treated by neurosurgical intervention. Although the incidence increases in the elderly population, there is a paucity of studies examining their surgical outcomes. To determine the neurological and functional outcomes of patients over 70 years of age undergoing surgical decompression for subdural hematoma. ...
Dolan Michael John - - 2013
Abstract Purpose: To characterise the provision of wheelchair seating both pre- and post-clinical intervention and compare and contrast the two largest diagnostic groups. Method: The case notes of those attending a wheelchair seating clinic for adults over a defined period were reviewed retrospectively. A classification system was devised that delineates ...
Youn Young Jin - - 2013
The second-generation drug-eluting stents (DES) have shown superiority in many studies relating to safety and efficacy when compared with the first-generation DES. However, it is unclear whether there are differences in efficacy and safety among the second-generation DES after long-term follow-up. This multicenter, prospective, randomized, open-labeled trial will directly compare ...
Mao Lizheng - - 2013
This study assessed the effects and safety of rivaroxaban versus warfarin in Chinese patients with atrial fibrillation. In this double-blind clinical trial, a total of 353 consecutive patients with atrial fibrillation who were at risk of stroke or systemic embolism were enrolled to receive either rivaroxaban or warfarin. The primary ...
Yuyun Matthew F - - 2013
Percutaneous catheter radiofrequency ablation (RFA) has been widely used to treat patients with atrial fibrillation (AF). Success rates are, however, variable and optimal levels of power used and duration of power delivery have not been fully established. Different ablation centers continue to use various power protocols. We undertook a comprehensive ...
Gans Itai - - 2013
Study Design: Therapeutic Level II Cohort Study.Objective: To evaluate the safety of adjunctive local application of vancomycin powder (VP) for infection prophylaxis in posterior instrumented thoracic and lumbar spine wounds in pediatric patients >25kg.Summary of Background Data: Spine surgeons have largely turned to vancomycin prophylaxis in an attempt to decrease ...
Kumar Neal - - 2013
Introduction: The biologic, Ustekinumab (Stelara®, Centocor, Inc., Malvern, PA, USA), is a fully human monoclonal antibody with a high affinity for the shared p40 subunit of interleukins 12 and 23 (IL-12 and IL-23). Approved for use in treating moderate-to-severe psoriasis in 2009, there has been considerable interest in the long-term ...
Matsuura Kaoru - - 2013
BACKGROUND: This study aimed to assess the impact of aortic manipulation during off-pump coronary artery bypass (OPCAB) on neurological complications. METHODS AND RESULTS: Of 336 isolated OPCAB surgeries, the aorta was untouched in 264 cases (group A), whereas it was manipulated by a side-biting clamp in 72 (group B). The ...
Pfeifer Rüdiger - - 2013
BACKGROUND AND PURPOSE: We investigated the inter-observer variability in interpretation of median nerve SSEPs with regard to neurological prognosis in survivors of cardiac arrest (CA). METHODS: Four experienced neurologists analyzed 163 median nerve SSEPs on the basis of a pre-defined classification of SSEPs into five patterns (A-E), with consideration of ...
Sørensen Rikke Terp - - 2013
Objectives: Dysphagia occurs in approximately 51%-78% of patients with acute stroke. The incidence of pneumonia caused by aspiration in dysphagic patients increases both mortality and the need for hospitalization. The aim of this study was to investigate whether the incidence of aspiration pneumonia could be reduced in such patients by ...
Li Kai Nan - - 2013
STUDY DESIGN:: Prospective study evaluates the safety of one-stage multisegmental thoracolumbar percutaneous balloon vertebroplasty. OBJECTIVE:: To discuss the safety of one-stage multisegmental thoracolumbar percutaneous balloon vertebroplasty. SUMMARY OF BACKGROUND DATA:: The percutaneous balloon vertebroplasty is a minimally invasive surgery. It is mainly used in treatment with serious back pain caused ...
Kim Young Dae - - 2013
To evaluate the efficacy and safety of sodium hyaluronate solution (SH) in endoscopic submucosal dissection (ESD) of gastric neoplasms. A prospective multicenter randomized, double blind, controlled trial was designed and utilized in this study. A total of 76 patients with 5-20 mm sized gastric neoplasms were enrolled at three academic ...
Bryer Alan - - 2013
BACKGROUND: Stroke is an important cause of death and disability in sub-Saharan Africa. Thrombolysis with recombinant tissue plasminogen activator (tPA) is the only effective therapy for acute ischaemic stroke. Essential requirements for stroke thrombolysis include availability of CT scanning and arrival at hospital within 4.5 hours of symptom onset. However, ...
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