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Jover Eva - - 2012
The risk of stroke in atrial fibrillation is heterogeneous and depends upon underlying clinical conditions included in current risk stratification schemes. Recently, the CHA(2)DS(2)-VASc score has been included in guidelines to be more inclusive of common stroke risk factors seen in everyday clinical practice, and useful in defining "truly low ...
Miteva Mariya - - 2012
Hair loss is a very common complaint. The diagnosis is based on clinical, dermoscopic and pathological examination. The treatment is usually continuous and requires strong compliance. This article aims to i) summarize current treatment options for the most common forms of hair loss; ii) update the literature on treatment options ...
Meuth Sven G - - 2012
Baseline disease-modifying therapies (DMTs) for multiple sclerosis (MS) include three different preparations of interferon-beta (IFN-) and glatiramer acetate (GA). These substances reduce relapse rates, side-effects are tolerated by most patients and - after more than 15 years of experience - the long-term safety profile for these drugs can be appraised ...
Bertrand Olivier F - - 2012
With femoral access, bivalirudin decreases risks of major bleeding after percutaneous coronary intervention (PCI) and provides better net clinical benefit compared to unfractionated heparin (UFH) plus planned glycoprotein IIb/IIIa inhibitors. Whether this benefit exists compared to UFH monotherapy is less clear. We performed a systematic review and meta-analysis to compare ...
Ito Sadayoshi - - 2012
High serum uric acid level (SUA) and chronic kidney disease (CKD) are risk factors for cardiovascular events (CVEs). However, their interactions as cardiovascular risk factors remain unknown. This subanalysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study included 7629 patients, in whom the serum creatinine ...
Cheung W Y - - 2012
INTRODUCTION: Tuberculosis of the spine is a still a common disease entity, not only in developing countries but is also returning in developed countries especially in the immune-compromised patients. Conservative treatment with chemotherapy is still the main stay of treatment. This article focuses on the clinical and radiological outcomes, and ...
Hankey Graeme J - - 2012
Anticoagulant therapy for ischaemic stroke aims to prevent recurrent ischaemic stroke and venous thromboembolism. Several large clinical trials have provided insight into the safety and efficacy of anticoagulant therapies. Anticoagulant treatment provides no net benefit over placebo or antiplatelet therapy in patients with acute ischaemic stroke of arterial or cardiac ...
Deftereos Spyridon - - 2012
Thrombosis plays a key role in the pathophysiology of acute coronary syndromes (ACS). The management of patients with ACS includes interventional procedures and use of antithrombotic agents acutely, and dual antiplatelet therapy (aspirin and a P2Y12 receptor antagonist) for secondary prevention. However, patients with recent ACS remain at a substantial ...
Chew Derek P - - 2012
PURPOSE OF REVIEW: This review seeks to describe the emerging clinical trial data that informs clinical practice with regards to dual antiplatelet therapy. RECENT FINDINGS: Recent evidence with vorapaxar has demonstrated an increase in bleeding events with only modest improvement in ischemic outcomes. Platelet function testing to inform clopidogrel dose ...
Castela E - - 2012
Topical steroids have been used for more than 50 years in mild-to-moderate plaque psoriasis and carry a theoretical risk of adverse events. The aim of this systematic literature review was to evaluate the risk of hypothalamo-pituitary-adrenal (HPA) axis suppression and the risk of skin atrophy with topical steroids in the ...
Divya K R - - 2012
The present study was conducted to assess the establishment and effect of probiotic bacteria such as Bacillus coagulans, Bacillus mesentericus, and Bifidobacterium infantis in the gut of freshwater ornamental fish Puntius conchonius. Postlarvae of 60 days old Puntius conchonius divided in four experimental groups each with three replicates. T1, T2 ...
Prater Sean N SN Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC, - - 2012
Enzyme replacement therapy with alglucosidase alfa for infantile Pompe disease has improved survival creating new management challenges. We describe an emerging phenotype in a retrospective review of long-term survivors. Inclusion criteria included ventilator-free status and age ≤6 months at treatment initiation, and survival to age ≥5 years. Clinical outcome measures ...
Grooteman Muriel P C - - 2012
In patients with ESRD, the effects of online hemodiafiltration on all-cause mortality and cardiovascular events are unclear. In this prospective study, we randomly assigned 714 chronic hemodialysis patients to online postdilution hemodiafiltration (n=358) or to continue low-flux hemodialysis (n=356). The primary outcome measure was all-cause mortality. The main secondary endpoint ...
Bernard Michael L - - 2012
Many patients receiving cardiac rhythm devices have conditions requiring antiplatelet (AP) and/or anticoagulant (AC) therapy. Current guidelines recommend a heparin-bridging strategy (HBS) for anticoagulated patients with moderate/high risk for thrombosis. Several studies reported lower bleeding risk with continued oral anticoagulation rather than HBS. The best strategy for perioperative management of ...
Tongsai Sasima - - 2012
Early ambulation after percutaneous coronary intervention (PCI) could increase patient comfort, decrease length of hospital stay, and reduce the costs. However, this approach may increase the risk of vascular complications and has not been well assessed. This study was conducted to assess the safety of early ambulation versus late ambulation ...
Márquez-Contreras Emilio - - 2012
To assess compliance with treatment inhibit the renin-angiotensin system (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) in uncontrolled hypertension in patients at high cardiovascular risk. Prospective, longitudinal, multicenter study, carried out in 102 Spanish primary care centers. We included 808 uncontrolled hypertensive patients treated with angiotensin-converting enzyme inhibitors or angiotensin ...
van Vark Laura C - - 2012
Renin-angiotensin-aldosterone system (RAAS) inhibitors are well established for the reduction in cardiovascular morbidity, but their impact on all-cause mortality in hypertensive patients is uncertain. Our objective was to analyse the effects of RAAS inhibitors as a class of drugs, as well as of angiotensin-converting enzyme (ACE) inhibitors and AT1 receptor ...
Rohof Wout O - - 2012
PURPOSE OF REVIEW: In recent years, several studies on the treatment and follow-up of achalasia have been published. This review aims at highlighting interesting publications from the recent years. RECENT FINDINGS: Treatment of achalasia aims at relieving functional obstruction at the level of the esophagogastric junction. Several treatment options such ...
Hunt Margie A - - 2012
PURPOSE: To review the type and frequency of patient events from external-beam radiotherapy over a time period sufficiently long to encompass significant technology changes. METHODS AND MATERIALS: Ten years of quality assurance records from January 2001 through December 2010 were retrospectively reviewed to determine the frequency of events affecting patient ...
Poddubnyy Denis - - 2012
PURPOSE OF REVIEW: Radiographic progression in the axial skeleton is considered as an important outcome in ankylosing spondylitis (AS) and in the whole group of axial spondyloarthritis (SpA). Recently new data on the rates and predictors of radiographic progression from observational cohorts have become available. Here we summarize recent data ...
Rahman Mahboob M Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals Case Medical Center, - - 2012
CKD is common among older patients. This article assesses long-term renal and cardiovascular outcomes in older high-risk hypertensive patients, stratified by baseline estimated GFR (eGFR), and long-term outcome efficacy of 5-year first-step treatment with amlodipine or lisinopril, each compared with chlorthalidone. This was a long-term post-trial follow-up of hypertensive participants ...
Eichinger Sabine - - 2012
Immediate intense anticoagulation with parenteral anticoagulants (heparin or fondaparinux) followed by vitamin K antagonists is the current standard therapy for deep vein thrombosis (DVT) or nonmassive pulmonary embolism. In the future, new oral anticoagulants may replace not only vitamin K antagonists but also initial parenteral anticoagulation. Duration of anticoagulation should ...
Kearon C - - 2012
Summary.  Four observations support that anticoagulant therapy for venous thromboembolism (VTE) has an 'active treatment' phase that is limited to about 3 months. First, <3 months of treatment is associated with a higher risk of recurrent VTE than treatment for 3 months or longer, suggesting that <3 months is inadequate therapy. Second, treatment for ...
Tandjung Kenneth - - 2012
Drug-eluting stents (DES) are increasingly used for the treatment of coronary artery disease. An optimized DES performance is desirable to successfully treat various challenging coronary lesions in a broad population of patients. In response to this demand, third-generation DES with an improved deliverability were developed. Promus Element (Boston Scientific, Natick, ...
Karthikesalingam Alan A Department of Outcomes Research, St George's Vascular Institute, London, - - 2012
To report a systematic review and meta-regression of the association between the threshold for intervention in patients with isolated type II endoleak after endovascular aneurysm repair (EVAR) and the fate of the aneurysm sac. Medline, trial registries, conference proceedings, and article reference lists were searched to identify case series reporting ...
Imberti Davide - - 2012
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular pathology after coronary disease and cerebrovascular diseases and is responsible for significant morbidity and mortality in the general population. Full-dose anticoagulation is the standard therapy for VTE, both the acute phase and ...
Mantziari Lilian - - 2012
Dosing of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in patients with heart failure (HF) treated with cardiac resynchronization therapy (CRT) may affect long-term outcomes. Retrospective data were collected at baseline and follow-up for consecutive patients who had CRT implanted and attended the institutional specialist HF pacing clinic. ...
Wise Gregory R - - 2012
Background:  Percutaneous coronary intervention (PCI) is the most commonly used procedure for coronary revascularization. There are multiple adjuvant anticoagulation strategies available. In this era of cost containment, we performed a comparative effectiveness analysis of clinical outcomes and cost of the major anticoagulant strategies across all types of PCI procedures in ...
Plaut Jennifer A - - 2012
Drought-related tree mortality occurs globally and may increase in the future, but we lack sufficient mechanistic understanding to accurately predict it. Here we present the first field assessment of the physiological mechanisms leading to mortality in an ecosystem-scale rainfall manipulation of a piñon-juniper (Pinus edulis-Juniperus monosperma) woodland. We measured transpiration ...
Hirano Mitsumasa - - 2012
Background: The resolution of hyperglycemia is associated with suppression of in-hospital cardiac complications in patients with acute coronary syndromes (ACS). This study evaluated carotid artery plaque echolucency using ultrasound in patients with ACS and type 2 diabetes mellitus (DM) to determine whether acarbose, an α-glucosidase inhibitor, may rapidly stabilize unstable ...
Zhao Yingnan - - 2012
Hypoglycemia is associated with failure to show cardiovascular benefit and increased mortality of intensive glycemic control in randomized clinical trials. This retrospective cohort study aimed to examine the impact of hypoglycemia on vascular events in clinical practice. Patients with type 2 diabetes were identified by ICD-9-CM codes (250.xx except for ...
Araujo Vanessa P - - 2012
Background: GH replacement therapy (GHRT) in adult-onset GH deficiency (AOGHD) reduces carotid intima media thickness (IMT) and increases myocardial mass, with improvement of systolic and diastolic function. We have previously reported that in adults with lifetime congenital and severe isolated GH deficiency (IGHD) due to a homozygous mutation in GHRH ...
Smith Phillip P - - 2012
AIMS: Bladder neck hypermobility (BNH, also called urethral hypermobility), and intrinsic sphincteric deficiency (ISD) are terms frequently used in the clinical evaluation and management of stress urinary incontinence, and as subject qualifiers in clinical research. The terms also infer pathophysiologic concepts, as BNH and ISD appear to represent two different ...
Mann Samuel J - - 2012
J Clin Hypertens (Greenwich). 2012;14:191-197. ©2012 Wiley Periodicals, Inc. This retrospective study assessed the efficacy of a recently described, mechanism-based algorithm for treating resistant hypertension. Charts of consecutive patients seen for resistant hypertension were reviewed. Algorithm-based intervention was limited to either or both of just 2 options: (1) strengthening of ...
Zenz Thorsten - - 2012
Standardized criteria for diagnosis and response evaluation in CLL are essential to achieve comparability of results and improvement of clinical care. With the increasing range and efficacy of therapeutic options, the specific treatment context is particularly important when defining refractory CLL. Refractory CLL has been defined as no response or ...
Khemasuwan Danai - - 2012
Venous thromboembolism (VTE) is a major public health concern since the incidence of VTE rises substantially with age. Furthermore, the diagnosis can be elusive since patients can present differently, causing delay in diagnosis and initiation of treatment and resulting in major morbidity and mortality. In addition to accuracy and precision ...
Karas Steve - - 2012
We performed a systematic review to assess the functional outcomes of Birmingham Hip Resurfacing as reported in peer-reviewed literature. We performed a computerized search on the data sources up to February 2011. The following text and key words were searched: "Birmingham hip", "Birmingham hip resurfacing" and "Hip resurfacing". Each of ...
Adcock Amelia K AK Department of Neurology, Mayo Clinic, Phoenix, Arizona 85054, - - 2012
Warfarin has provided protection against cardioembolic stroke in the setting of nonvalvular atrial fibrillation (NVAF) for the past 60 years. Dabigatran, the first oral direct thrombin inhibitor to be approved in the United States, promises to provide the same or better stroke protection with reduced risk of intracranial hemorrhage. However, ...
Vinther Siri - - 2012
Internationally, the number of authors per scientific article is increasing. The objective of this study was to determine authorship trends over the past fifty years in Ugeskrift for Læger (UfL). From 1960 to 2010, ten volumes of the UfL, 5,962 articles in total, were studied. For each article, category and ...
Cram Peter - - 2012
Administrative data are commonly used to examine orthopedic outcomes including total hip arthroplasty (THA), but little is known about how minor analytic decisions impact results. Our objective was to examine how the rates of 3 adverse outcomes (deep vein thrombosis [DVT], pulmonary embolism [PE], and hemorrhage) varied with subtle adjustments ...
García Francisca F Department of Vascular Surgery, University Hospital Dr. Negrín, Las Palmas de Gran Canaria, - - 2012
This study was done to determine the usefulness of the American Society of Anesthesiologists (ASA) classification, the comorbidity Charlson index unadjusted (CCIu),the comorbidity Charlson index adjusted by age (CCIa), and the Glasgow aneurysm score (GAS) for postoperative morbimortality and survival in patients treated with aorto-bifemoral bypass (AFB) for aorto-iliac occlusive ...
Riedl Marc - - 2012
BACKGROUND: Hereditary angioedema (HAE) is a rare, potentially life-threatening autosomal dominant disease characterized by recurrent angioedema attacks that affect the skin, gastrointestinal tract, and airway, including the larynx. Pharmacologic developments in HAE treatment have culminated in the recent introduction of 4 new HAE-specific therapies in the United States. OBJECTIVES: In ...
Bassand Jean-Pierre - - 2012
Atrial fibrillation (AF) is strongly associated with cardioembolic stroke, and thromboprophylaxis is an established means of reducing stroke risk in patients with AF. Oral vitamin K antagonists such as warfarin have been the mainstay of therapy for stroke prevention in patients with AF. However, they are associated with a number ...
Kuklina Elena V - - 2012
Progress in the treatment of spinal cord injury (SCI) has increased patient survival drastically over the last 50 years.(1) An estimated 232,000 to 316,000 persons in the United States live with SCI.(2) Fortunately, mortality in the first 2 years after injury has declined 40% over the last 3 decades(3); in ...
Digiuni Maurizio - - 2012
Prostaglandins are increasingly used as first choice treatment for glaucoma because they are highly effective, lack relevant systemic side effects and require just once-daily administration. Latanoprost is an ester prodrug analog of prostaglandin F2α, which reduces intraocular pressure (IOP) by increasing uveoscleral outflow. Latanoprost 0.005% has received European and US ...
Ho Ken Hm - - 2012
Aims.  To design clinical guidelines on timing for replacing peripheral intravenous catheters, in an attempt to decrease complications and lower related expenditures. Background.  Intravenous therapy is a common intervention for patients in hospitals and some other clinical settings. However, the currently available international and local guidelines have come under criticism. ...
Sigala Fragiska - - 2012
We aimed to determine the long-term results after infrapopliteal PTA (primary patency, limb salvage, survival) and examine for association with risk factors (e.g. diabetes, infection, etc). We studied 268 patients with 282 critically ischemic limbs treated with PTA of at least one crural artery during a six-year period. Data included ...
Owen Jesse - - 2012
The purpose of this study was to investigate the relationship between client initial goal for couple therapy (i.e., improve the relationship or clarify the viability of the relationship) and the outcomes (including their relationship status, i.e., separated or together) at posttreatment as well as at 6-month follow-up. Two hundred forty-nine ...
Mathieu Sylvain - - 2012
Objective. The excess cardiac risk, found in RA has been attributed to biological inflammation. Effective control of inflammation may be of benefit in reducing cardiovascular risk in RA patients. The aim of this study is to investigate the effects of 24 and 52 weeks of rituximab treatment on arterial stiffness ...
Basco Maria T - - 2012
Endovascular techniques have been playing an increasing role in managing lower extremity chronic critical limb ischemia (CLI) in patients considered poor or non-candidates for surgical revascularization secondary to co-morbidities such as coronary artery disease, uncontrolled hypertension, diabetes mellitus or inadequate conduit. This study reviews our recent clinical experience in the ...
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