OBJECTIVES: To determine the safety of intramyocardial injection of autologous bone marrow cells in patients undergoing surgical myocardial revascularization (CABG) for severe coronary artery disease. INTRODUCTION: There is little data available regarding the safety profile of autologous bone marrow cells injected during surgical myocardial revascularization. Potential risks include arrythmias, fibrosis ...

PURPOSE: To present the results of dextrose prolotherapy undertaken for chronic non-responding coccygodynia in 37 patients. METHODS: 14 men and 23 women (mean age, 36 years) with chronic coccygodynia not responding to conservative treatment for more than 6 months were included. 27 of them had received local steroid injections. A ...

PURPOSE: This study was designed to test the null hypothesis that there is no difference in resolution of triggering 3 months after injection with either a soluble (dexamethasone) or insoluble (triamcinolone) corticosteroid for idiopathic trigger finger. METHODS: Eighty-four patients were enrolled in a prospective randomized controlled trial comparing dexamethasone and ...

OBJECTIVE: To assess whether walking velocity could be improved in patients with disorders related to upper-motor neuron syndrome (UMNS) by treating elbow flexor spasticity with botulinum toxin type A (BoNTA). DESIGN: This was a prospective, open-label, multicenter, interventional evaluation. The study group of 15 patients (mean age, 51.3 yrs; ten ...

OBJECTIVE: To report the efficacy of botulinum toxin A for radiation-induced pain, trismus, and masticator spasm in head and neck cancer. PATIENTS AND METHODS: This prospective nonrandomized study included patients in complete remission with radiation-induced pain and trismus with or without masticator spasms. Fifty units of Botox (Allergan) or 250 ...

BACKGROUND: Calcium hydroxylapatite (CaHA) is presently approved for the correction of moderate to severe facial wrinkles and folds and signs of HIV-associated facial lipoatrophy. OBJECTIVE: This 6-month pilot study was designed to evaluate clinical efficacy and patient satisfaction of CaHA to treat mid-face volume loss. METHODS: Nineteen patients received initial ...

BACKGROUND: We examined, for the first time in a prospective study, the histological changes in the urothelium and suburothelium of patients with neurogenic (NDO) or idiopathic detrusor overactivity (IDO) after one or repeat treatments with intradetrusor BoNTA. METHODS: Flexible cystoscopic bladder biopsies were obtained from patients with urodynamically proven intractable ...

Vesicoureteral reflux (VUR) is a common urinary tract anomaly. Treatment is performed to minimize the risk of febrile urinary UTIs that may result in renal scarring. The endoscopic use of dextranomer hyaluronic acid copolymer has been gaining popularity as an alternative to the traditional methods of open surgery and chronic ...

BACKGROUND AND PURPOSE: We compared the efficacy of botulinum toxin injection (BTI) and tibial nerve neurotomy (TNN) in an open-label study of 34 post-stroke hemiplegic patients with distal lower limb deformation. METHODS: The dose of BT was 300 U (Botox). TNN was performed with a 6-12 month delay on the ...

The aim of this randomized control trial, performed at a tertiary referral hospital, was to compare the therapeutic effectiveness of two novel treatment modalities, oral rifampicin and submucosal placentrex injection, in randomly selected patients of primary atrophic rhinitis regarding objective, subjective and histopathological improvement. Patients treated with oral rifampicin showed ...

BACKGROUND: Local intradermal injection of botulinum toxin Type A has become a recognized treatment for axillary hyperhidrosis. This study has investigated the efficacy of this method of treatment in terms of symptom-free interval between treatments and patients' satisfaction. We also investigated the reliance on patients' subjective assessment of the recurrence ...

Cicatricial lower eyelid ectropion is caused by a shortening of the anterior lamella, with resultant eversion of the eyelid away from the globe. Treatment is typically surgical; however, the author hypothesized that a nonsurgical injection of hyaluronic acid filler could stretch the tethered skin and act as a tissue expander ...

BACKGROUND: Chronic urticaria (CU) is one of the most challenging and frustrating therapeutic problems faced by a dermatologist. A recent demonstration of abnormal type 1 reactions to intradermal autologous serum injections in some CU patients has led to the characterization of a new subgroup of "autoimmune chronic urticaria". This has ...

OBJECTIVE: We compared the efficacy of intra-sphincteric botulinum toxin (BT) injection and posterior anorectal myectomy (PARM) for the treatment of internal anal sphincter achalasia (IASA). METHODS: Twenty eight of 120 patients (23%) with chronic constipation, who were referred to our clinic from September 2005 to December 2006, were evaluated. Patients ...

OBJECTIVE: To describe the use of botulinum toxin type A (BTX-A) in radiation fibrosis syndrome (RFS). DESIGN: Retrospective case series. SETTING: A large tertiary care cancer center. PARTICIPANTS: Twenty-three consecutive patients treated for sequelae of RFS with BTX-A. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: A description of the components of ...

BACKGROUND: Polyacrylamide hydrogel (PAHG) is widely used in biomedical research and industry and has been used as a soft tissue filler in some countries for more than a decade. OBJECTIVE: The author evaluated the results of malar area augmentation with PAHG. METHODS: Results from 1306 patients who were treated with ...

BACKGROUND: Chylothorax is a disorder with a variety of causes and is often difficult and complex to manage. There are two treatment options for chylothorax: conservative management or surgical intervention. Conservative management of chylothorax consists of pleural fluid drainage, supportive ventilation, supplementation of fluid loss, and elemental diet or total ...

OBJECTIVE: To evaluate the efficacy of injectable calcium hydroxylapatite for treatment of velopalatal (VP) insufficiency (VPI). DESIGN: Observational case series of 7 patients treated with injectable calcium hydroxylapatite for VPI and followed for 10 to 24 months. SETTING: Academic pediatric otolaryngology practice. PATIENTS: Seven children aged 6 to 16 years ...

OBJECTIVE: Over the past 20 years endoscopic treatment (ET) of vesicoureteral reflux (VUR) has changed the algorithm of reflux management. We describe a modification of the standard subureteral injection (STING) that has contributed to the increased success rate of this procedure. METHODS: Between January 2006 and December 2006 192 children, ...

The aim of this study was to demonstrate the efficacy of methylprednisolone, as a single 40-mg dose, injected into the masseter muscle upon completion of extraction of impacted lower third molars. A prospective, randomized cross-over study was made of 35 healthy patients. The difficulty of extraction was similar in all ...

PURPOSE: To determine patient-preferred injection sites and frequency for facial volume augmentation with nonanimal stabilized hyaluronic acid (Restylane). METHODS:: The authors retrospectively reviewed the records of 145 consecutive patients who received 0.4 ml or 1.0 ml subcutaneous facial injections of Restylane. Location, amount, supplemental anesthetic, injection frequency, follow-up time, and ...

Botulinum toxin type A (BTX-A) can be used in various medical fields for more than simply cosmetic purposes, especially in pain control. Unlabelled uses of BTX-A for reducing pain include migraines, chronic anal fissures, chronic non-specific muscular pain syndrome, and temporomandibular joint arthritis. However, there are no reports of using ...

OBJECTIVE: To investigate the effect of intralesional Pingyangmycin injection in venous malformation of facial and maxillary region. MATERIALS AND METHODS: From September 2001 to October 2004, 82 patients were referred with venous malformation for intralesional Pingyangmycin injection. RESULTS: After a minimum follow-up of 2 years, 67 patients (81.7%) developed 76-100% ...

BACKGROUND: Sialorrhea is a disabling problem in bulbaronset amyotrophic lateral sclerosis (ALS). Botulinum toxin (BTX) type A and B have been proposed as alternatives to traditional treatments. OBJECTIVES: To evaluate the efficacy and safety of BTX type B in the treatment of sialorrhea in patients with bulbar-onset ALS. METHODS: Open-label ...

OBJECTIVES: Chronic aspiration of salivary secretions can cause major pulmonary morbidity in neurologically impaired patients. Many treatments are proposed to address these problems, some with significant side effects. Botulinum toxin type A injection into the salivary glands is known to reduce salivary flow without major complications. Few reports exist regarding ...

OBJECTIVE: Osseous changes in the temporomandibular joint (TMJ) were evaluated using computed tomography (CT) examinations before and after TMJ injections of sodium hyaluronate or a corticosteroid in patients with osteoarthritis (OA). STUDY DESIGN: Forty patients were randomly allocated into 2 groups for 2 intra-articular injections with either sodium hyaluronate or ...

OBJECTIVE: To assess different approaches to the dental management of lip injuries caused by self-inflicted oral trauma in 7 patients. METHOD AND MATERIALS: The patients were grouped based on 3 treatment approaches: group 1, placement of an oral appliance; group 2, botulinum toxin type A neuromuscular block; and group 3, ...

Personal experience is discussed in the use of botulinum neurotoxin injections into both parotids, performed in order to transiently reduce salivation in patients undergoing major ablative and ablative-reconstructive oncologic surgery for head and neck tumours. Overall, 8 adult patients (2 female, 6 male) have been treated. Six cases were affected ...

AIM: To investigate whether a relationship exists between preoperative intra-articular steroid injections and postoperative wound healing in total knee arthroplasty (TKA). Similar research studies on total hip arthroplasty (THA) have found higher rates of post surgical problems in hips that have been injected with steroids. METHODS: Thirty-eight patients with TKA ...

The aim of this trial was to examine the effects after 2 years of a single intravesical botulinum toxin-A injection (BTX-A). This prospective, observational study was conducted using urodynamic measurements and quality of life (QoL) assessment to document the effect after 2 years of a single 100 I.U. injection of ...

PURPOSE: We evaluated the 1-year efficacy and tolerability of botulinum A toxin intravesically injected in patients with painful bladder symptoms associated with increased urinary frequency, refractory to conventional treatments. MATERIALS AND METHODS: Three men and 12 women were prospectively included in the study. Under short general anesthesia the patients were ...

PURPOSE: Dextranomer/hyaluronic acid copolymer has become a popular bulking agent for subureteral injection in the treatment of vesicoureteral reflux. The success rates are lower compared to ureteral reimplantation, and, therefore, postoperative voiding cystourethrography is required. We sought to determine if post-injection intraoperative cystography can be useful in improving the success ...

PURPOSE: To assess the impact of upper eyelid myectomy surgery on blepharospasm with associated apraxia of lid opening (ALO), dry eye, photophobia, and daily functioning in patients who are refractory to botulinum toxin treatment. DESIGN: Noncomparative, consecutive, interventional case series. METHODS: A retrospective chart review was performed to identify 100 ...

OBJECTIVE: To study efficacy and safety of corticosteroid injections for trigger finger (flexor tenosynovitis) in adults in general practice. METHODS: Adult patients presenting with trigger finger were recruited by 21 participating general practitioners. In this randomised placebo controlled double-blinded trial, patients were injected locally with one or two injections of ...

INTRODUCTION: Healing rates for botulinum toxin injection for anal fissure may be improved if combined with fissurectomy. This procedure has a decreased risk of incontinence, which is particularly important in females. We investigated the long-term efficacy of fissurectomy and botulinum toxin injection for chronic resistant fissures in females. METHODS: Female ...

<b>Aim:</b> Our aim in this study is to evaluate the effect of ethanol as a sclerosing agent on subset of pediatric patients with prolonged rectal prolapse. <b> Materials and Methods:</b> From 1997 to 2003, 165 cases of primary rectal prolapse were treated by submucosal injection of ethyl alcohol (96&#x0025;) after ...

The syndrome of retained placenta is an important problem that affects cows in the farms of Iran and other countries. In a study on the cows with retained placenta, the effect of prostaglandin injections on the mean time of placental expulsion was studied. Cows with retained placenta (n = 150) ...

The syndrome of retained placenta is an important problem that affects cows in the farms of Iran and other countries. In a study on the cows with retained placenta, the effect of prostaglandin injections on the mean time of placental expulsion was studied. Cows with retained placenta (n = 150) ...

PURPOSE: To evaluate a novel conservative management modality for patellar tendinopathy. METHODS: We recruited nine patients with patellar tendinopathy who had failed conservative management and showed evidence of neovascularisation on power Doppler scanning. A high volume ultrasound guided injection at the interface between the patellar tendon and Hoffa's body. The ...

AIM: To clarify the factors affecting the success rate of endoscopic subureteral injection (ESI) treatment of vesicoureteral reflux (VUR). METHOD: All patients who had ESI treatment for VUR at our unit between 1999 and 2002 were retrospectively reviewed with regard to age, gender, causes of VUR, reflux grade, type of ...

OBJECTIVE: To evaluate the effectiveness and safety of botulinum toxin A injection in treating overcorrected and undercorrected strabismus after unsatisfactory postoperative alignment. MATERIAL AND METHOD: The authors reviewed the outcomes of 20 patients aged 5 to 56 years (mean 29.1 years) who had botulinum toxin A injection following their unsatisfactory ...

AIMS: We evaluated the effect of botulinum toxin type A (BTX-A) injections in the trigone on the antireflux mechanism and evaluated its short-term efficacy. MATERIALS AND METHODS: Between April and December 2006, 21 patients (10 men and 11 women) were prospectively evaluated. All were incontinent due to refractory NDO and ...

OBJECTIVE: To assess patient satisfaction with vertigo control using intratympanic (IT) dexamethasone (12 mg/mL) for medically refractory unilateral Ménière's disease. STUDY DESIGN: Retrospective study. SETTING: Tertiary referral neurotology clinic. PATIENTS: One hundred twenty-nine subjects diagnosed with unilateral Ménière's disease still having vertigo despite medical therapy. INTERVENTION: IT dexamethasone injections as ...

To present a new classification of 15 anatomical lip zones used to direct placement of injectable fillers during lip augmentation and to evaluate the new classification's ability to customize lip contour and size. Study participants were consecutive patients presenting to a facial plastic and reconstructive surgery practice for injectable lip ...

INTRODUCTION: Peyronie's disease afflicts at least 3% of sexually active men over the age of 30. Many pharmacologic therapies have been tried, but to date, no systemic or local therapy has been proven to provide predictable and lasting results. AIM: This study was designed to assess the efficacy and safety ...

Our aim in this study is to evaluate the effect of ethanol as a sclerosing agent on subset of pediatric patients with prolonged rectal prolapse. From 1997 to 2003, 165 cases of primary rectal prolapse were treated by submucosal injection of ethyl alcohol (96%) after 8 weeks of conservative therapy. ...

PURPOSE: The goal of this review is to present current indications, injectable agents, techniques, success rates, complications, and potential future applications of endoscopic treatment for vesicoureteral reflux (VUR) in children. MATERIALS AND METHODS: The endoscopic method currently achieving one of the highest success rates is the double hydrodistention-implantation technique (HIT). ...

OBJECTIVE: To evaluate the efficacy of botulinum toxin (BTX-A) injection in the cricopharyngeus muscle in patients with neurological dysphagia caused by alteration in the upper esophageal sphincter (UES) opening and with preserved pharyngeal contraction. MATERIAL AND METHODS: A prospective pilot study was undertaken in 10 patients (7 brain lesions and ...

PURPOSE: To determine the effect of the coinjection of bupivacaine with botulinum toxin type A on the degree of muscular paralysis. Enhancement of paralysis could allow a decreased dose of neurotoxin treatment, thus reducing the risk for neutralizing antibody formation. METHODS: Prospective, randomized, double-blind study. Sixteen consecutive patients undergoing treatment ...

BACKGROUND: Inflammatory responses after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) are not clarified. The aim of this study was to investigate the influence of intracoronary injection of mBMC on inflammatory mediators in patients with acute myocardial infarction (AMI). METHODS: Patients with AMI in the ASTAMI trial (N ...