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Rowe Steven M SM University of Alabama at Birmingham, Department of Medicine, Birmingham, Alabama, United States ; - - 2014
Rationale: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator recently approved for cystic fibrosis (CF) patients age 6 and above with the G551D mutation. Objectives: To evaluate ivacaftor in a post-approval setting and determine mechanism of action and response of clinically relevant markers. Methods: We conducted a longitudinal ...
Kozek-Langenecker Sibylle A SA Department of Anesthesia and Intensive Care, Evangelical Hospital Vienna, Hans-Sachs-Gasse, Vienna, - - 2014
Bleeding can be minimal, severe, life-threatening, or organ-threatening. Depending on the compensatory capacity of the patient, most bleeding events going beyond 20% blood volume may represent an emergency as well as a risk factor for anemia, transfusion, coagulopathy, and tissue hypoperfusion. All these factors are independent predictors for survival in ...
Smith Kristine A KA Ohlson Research Initiative, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Calgary, Calgary, Alberta, - - 2014
IMPORTANCE Tracheotomy is a common procedure. Postoperative care is usually managed by nonexpert clinicians. Prolonged decannulation is associated with a high incidence of complications. At present, no clinical protocol exists to guide clinicians through decannulation. To address this deficiency, we developed a low-risk tracheotomy clinical pathway. OBJECTIVE To determine the ...
Zou Yun Y Department of Cadres Clinic, School of Stomatology, China Medical University, Shenyang, China; Department of Materials, School of Stomatology, China Medical University, Shenyang, - - 2014
The purpose of this study was to evaluate the impact of psychological intervention on edentulous patients' satisfaction with complete clinically satisfactory complete dentures. The survey was conducted in China Medical University involving 84 individuals receiving complete dentures at this institution from August 2013 to March 2014. Participants were randomly allocated ...
Cadossi Matteo M Rizzoli Orthopaedic Institute, Bologna, Italy University of Bologna, Bologna, - - 2014
Osteochondral lesions of the talus (OLT) frequently occur after ankle sprains in young patients participating in sports activities. These injuries may lead to chronic pain, joint swelling, and finally osteoarthritis, therefore, surgical repair is frequently needed. A collagen scaffold seeded with bone marrow-derived cells (BMDCs) harvested from patient's iliac crest ...
Chauhan Balwantray C BC Department of Ophthalmology and Visual Sciences, Dalhousie University, 1276 South Park Street, 2W Victoria, Room 2035, Halifax, Nova Scotia, B3H 2Y9, Canada - - 2014
Purpose: To determine the rate of glaucomatous visual field change in routine clinical care. Methods: Mean Deviation (MD) rate was computed in one randomly selected eye of all glaucoma patients and suspects with ≥ 5 examinations in a tertiary eye-care centre. Proportions of "fast" (MD rate, < -1 to -2 ...
Keeler Bd B Division of GI Surgery, University of Nottingham, UK; Department of Colorectal Surgery, Nottingham University Hospitals NHS Trust, - - 2014
The study aimed to analyse the feasibility and efficacy of administration of a single intravenous iron infusion (IVI) in the preoperative optimisation of anaemic colorectal cancer patients. Twenty patients were recruited at least 14 days before the planned date of surgery. A single 1000mg dose of Ferric Carboxymaltose (FERINJECT(®) ) ...
Nestler David M DM The Department of Emergency Medicine, Mayo Clinic College of Medicine, Rochester, - - 2014
Patient throughput is an increasingly important cause of emergency department (ED) crowding. The authors previously reported shorter patient length of stay (LOS) when adding a triage liaison provider, which required additional personnel. Here, the objective was to evaluate the effect of moving a fast-track provider to the triage liaison role. ...
Watanabe Yusuke Y Institut Cardiovasculaire Paris Sud, Massy, France. Electronic address: - - 2014
The efficacy and safety of transcatheter aortic valve implantation (TAVI) in Asian populations were unknown. The purpose of this study was to compare directly the clinical outcomes of the first Japanese trial and a European single-center experience after TAVI. Between April 2010 and October 2011, 64 patients were included in ...
Brodie Jonathan J Radiology Department, Norfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UY, - - 2014
The term "superficial femoral vein" is felt to be potentially misleading and dangerous in the context of deep venous thrombosis (DVT) of the lower limb, with the preferred term now being "femoral vein." The purpose of this work was to identify a means of reducing its use in reports of ...
Um Mi Hyang MH Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, 446-791, South Korea, - - 2014
This study was conducted for the nutritional assessment of cancer patients undergoing radiotherapy (RT) and to investigate the changes in nutrition status, oral intake, morbidity and quality of life (QOL) in cancer patients after intensive nutrition counseling. Eighty-seven cancer patients were randomized to either a nutrition counseling group (n = 44, age ...
Honda Yohsuke Y Gunma Prefectural Cardiovascular Center, 3-12, Kameizumi-machi, Maebashi, Gunma, 371-0004, Japan, - - 2014
In the drug-eluting stent era, the outcome of patients undergoing percutaneous coronary intervention (PCI) has remarkably improved. Nevertheless, non-target lesion revascularization (non-TLR) is often performed even after successful PCI and optimized medical therapy. This study aimed to determine the predictor of non-TLR. In all, 125 consecutive patients with stable angina ...
Clerveus Michael M Department of Surgery, "Mancha Centro" General Hospital, Avd. de la Constitución no. 3, 13600, Alcázar de San Juan, Ciudad Real, - - 2014
The aim of this systematic review was to compare postoperative outcomes between pancreaticogastrostomy and pancreaticojejunostomy after pancreaticoduodenectomy. Six databases were systematically reviewed to identify randomized controlled trials comparing pancreaticogastrostomy and pancreaticojejunostomy. Studies reporting postoperative complications, reoperations, and mortality were included (PROSPERO registration number CRD42013005383). The search provided a total of ...
Zang Jinfeng J Department of Hepatobiliary Surgery, Taizhou People's Hospital, the Fifth Affiliated Hospital of Medical School of Nantong University, Taizhou, Jiangsu Province, - - 2014
Precut techniques have been used to facilitate biliary cannulation during difficult endoscopic retrograde cholangiopancreatography. Presently, needle-knife sphincterotomy (NKS) is a commonly used precut technique. Since its first description, transpancreatic sphincterotomy, as an alternative method for bile duct entry when conventional biliary cannulation failed, has been debated on its success rate ...
Shams Pari N PN South Australian Institute of Ophthalmology, Department of Ophthalmology and Visual Sciences, Adelaide University, Adelaide, South Australia, - - 2014
IMPORTANCE Approximately 5% to 10% of patients continue to experience persistent epiphora following an anatomically successful dacryocystorhinostomy (DCR) for nasolacrimal duct obstruction or stenosis. OBJECTIVE To investigate the management and success rate of so-called "functional failure" of DCR for nasolacrimal duct obstruction by experienced lacrimal surgeons. DESIGN, SETTING, AND PARTICIPANTS ...
Charoenkwan Kittipat K Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, Thailand, - - 2014
This is an updated version of the original Cochrane review published in Issue 1, 2010. Pelvic lymphadenectomy is associated with significant complications including lymphocyst formation and related morbidities. Retroperitoneal drainage using suction drains has been recommended as a method to prevent such complications. However, this policy has been challenged by ...
Park Jong-Hwa JH *Department of Neurosurgery, Spine Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea †Department of Orthopedic surgery, Spine Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of - - 2014
Retrospective case-control study. It has been reported that adjacent segment ossification development (ASOD) commonly occurs after anterior cervical arthrodesis. To compare the efficacy of the short plate and oblique screw trajectory with the traditional long plate and parallel screw trajectory by investigating the incidence of ASOD and graft subsidence. We ...
Baghdadi Yaser M K YM Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, - - 2014
Elbow prosthetic replacement in patients with juvenile idiopathic arthritis (JIA) can be complicated and technically challenging. Thus, we sought to evaluate the clinical benefit and the prosthetic longevity of primary semiconstrained linked total elbow arthroplasty (TEA) performed to treat these patients. Between 1983 and 2005, 29 elbows in 24 patients ...
Hallet Julie J Division of General Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Surgical Oncology, Sunnybrook Health Sciences Centre-Odette Cancer Centre, Toronto, Ontario, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, - - 2014
Perioperative anemia is common, yet detrimental, in surgical patients. However, red blood cell transfusions (RBCTs) used to treat anemia are associated with significant postoperative risks and worse oncologic outcomes. Perioperative iron has been suggested to mitigate perioperative anemia. This meta-analysis examined the impact of perioperative iron compared to no intervention ...
da Silva Edina Mk EM Emergency Medicine and Evidence Based Medicine, Universidade Federal de São Paulo, Rua Borges Lagoa 564 cj 64, Vl. Clementino, São Paulo, São Paulo, Brazil, - - 2014
Early recovery is an important factor for people undergoing facial plastic surgery. However, the normal inflammatory processes that are a consequence of surgery commonly cause oedema (swelling) and ecchymosis (bruising), which are undesirable complications. Severe oedema and ecchymosis delay full recovery, and may make patients dissatisfied with procedures. Perioperative corticosteroids ...
Beaupre Lauren A - - 2014
Total Hip Arthroplasty (THA) is being used more commonly in younger higher demand patients. The purpose of this randomized pilot study was to explore a) feasibility of comprehensive postoperative rehabilitation compared to usual care following primary THA in subjects <65 years, b) appropriate outcome measures including performance-based measures and c) ...
Günaydın Rıza Önder RO Hacettepe University, Faculty of Medicine, Otolaryngology Department, Ankara, Turkey. Electronic address: - - 2014
The scope of the study is to compare endolaryngeal dilatations (ED) with laryngotracheal reconstruction with cartilage grafting (LTRCG) in terms of restenosis. Pediatric subglottic stenosis patients treated in Hacettepe University, between 2002 and 2012 were retrospectively evaluated. Patients who had ED or LTRCG as primary management were included in the ...
Jitpakdee Thanaporn T Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok, - - 2014
Opioid is the gold standard for treating moderate-to-severe pain in pediatric patients. However, its undesirable side effects lead to unsatisfied postoperative pain management outcome (Pediatr Anesth, 17, 2007, 756). The most commonly reported opioid-related side effects are vomiting (40%), pruritus (20-60%) (Anesthesiology, 77, 1992, 162; Drugs, 67, 2007, 2323), and ...
Lenhardt Rainer R From the *Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, Kentucky; †Outcomes Research Consortium, Cleveland, Ohio; and ‡School of Public Health and Information Sciences, University of Louisville, Louisville, - - 2014
Failed intubation may result in both increased morbidity and mortality. The combination of a video laryngoscope and a flexible tracheoscope used as a flexible video stylet may improve the success rate of securing a difficult airway. We tested the hypothesis that this combination is a feasible way to facilitate intubation ...
Conti Duccio - - 2014
In Europe, standardized criteria for recovery room (RR) requirements have not been established. The purpose of this study was to examine the clinical utility of an undersized nurse-operated RR in an Italian community hospital. Single-center observational study. A total of 1,945 consecutive surgical patients admitted to the RR at the ...
Pulikkotil Sj S Department of Restorative Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, - - 2014
Fibrin sealant (FS) is a biologically derived tissue adhesive for securing flaps. The aim of the present randomized controlled clinical trial was to compare early wound healing by assessing interleukin-1β (IL-1β) and interleukin-8 (IL-8) levels from gingival crevicular fluid (GCF) after using FS and suture for periodontal flap closure. Thirty ...
Ford Eric C EC Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD - - 2014
Explore the feasibility and impact of a streamlined failure mode and effects analysis (FMEA) using a structured process that is designed to minimize staff effort. FMEA for the external beam process was conducted at an affiliate radiation oncology center that treats approximately 60 patients per day. A structured FMEA process ...
Pajares Virginia V Department of Respiratory Medicine, Biomedical Research Institute Sant Pau (IIb Sant Pau), Barcelona, Spain; Department of Medicine, Universidad Autónoma de Barcelona, Barcelona, - - 2014
Transbronchial lung biopsy (TBLB) is required for evaluation in selected patients with interstitial lung disease (ILD). The diagnostic yield of histopathologic assessment is variable and is influenced by factors such as the size of samples and the presence of crush artefacts left by conventional biopsy forceps. We compared the diagnostic ...
Kim Byeong-Keuk BK Yonsei Cardiovascular Center, Yonsei University College of Medicine, Division of Cardiology of Yonsei Cardiovascular Center, Seodaemun-gu, Shinchondong, Shinchon Severance Hospital, Seoul 120-752, South Korea. - - 2014
To investigate the impact of the success or failure of chronic total occlusion (CTO) interventions on the clinical outcomes in the current drug-eluting stent (DES) era. The impact of the successful CTO intervention on long-term clinical outcomes still remains unclear. Between 2007 and 2009, a total of 2568 patients with ...
Cheng Han-Chih HC Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, - - 2014
To compare the effect of myopia control between patients treated with low-concentration atropine eye drops combined with auricular acupoint stimulation and those treated with atropine alone. Single-blinded randomized controlled clinical trial in a regional teaching hospital. The patients received either topical 0.125% atropine nightly plus auricular acupoint stimulation (0.125A+ACU group) ...
Orzalkiewicz Mateusz M Papworth - - 2014
The use of balloon aortic valvuloplasty (BAV) is increasing in the current transcatheter aortic valve replacement (TAVR) era. There are no clear guidelines regarding follow-up or predictors of functional and echocardiographic recovery following BAV, which can affect timing of subsequent intervention. We present our experience of BAV. We performed retrospective ...
Rajani Nikil K NK Department of Interventional Cardiology, Papworth - - 2014
Randomised controlled trials have demonstrated that transradial (TR) percutaneous coronary intervention (PCI) reduces bleeding and improves survival compared with transfemoral access (TF). This benefit may be most marked in the context of primary PCI (pPCI) for ST-elevation myocardial infarction. Due to the learning curve associated with TR PCI, these benefits ...
Patel Niket N Oxford University - - 2014
Limited data exists about management and outcome following presentation with unprotected left mainstem occlusion (ULMSO). To evaluate in-hospital outcomes and one-year mortality of patients presenting with ULMSO treated with primary percutaneous coronary intervention (PPCI). 400,985 PCI cases were recorded in the British Cardiovascular Intervention Society database of all PCI cases ...
Thiel John A JA University of Saskatchewan, Department of Obstetrics, Gynecology and Reproductive Sciences, Regina - - 2014
Objective: To evaluate procedure-related adverse events, post-procedure menstrual bleeding status, and surgical re-intervention in women with a sounded uterine length > 10 cm compared to women with a sounded uterine length ≤ 10 cm who underwent the NovaSure endometrial ablation procedure. Methods: We conducted a retrospective cohort study of 188 ...
Jiang Yi Y Department of Joint Reconstructive Surgery, Beijing Jishuitan Hospital, Beijing 100035, - - 2014
Venous thromboembolism (VTE) is an important complication after major orthopedic surgery. Pharmaceutical methods represent the main strategy of VTE prevention. The use of aspirin in VTE prevention is still controversial worldwide, especially in China. The purpose of this study was to evaluate the role of aspirin combined with mechanical measures ...
Singh Rishi P RP Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, - - 2014
To evaluate efficacy and safety of intravitreal aflibercept injection (IAI) in subjects who were previously treated with ranibizumab and/or bevacizumab for active exudative age-related macular degeneration (AMD). Patients (n=26) were enrolled in a 12-month prospective, interventional, single arm, investigator-initiated study with planned 6-month interim analysis. Patients with active exudative AMD, ...
Nair Rajesh R Vancouver Island Health Authority, Victoria, Canada. - - 2014
We conducted a systematic review to consolidate the body of knowledge about use of computer navigation systems in unicompartmental knee arthroplasty (UKA), to determine whether these systems are useful in UKA, and to discuss the financial costs involved. We searched Medline (2002 to 2013) for articles in which results of ...
Kroon Féline - - 2014
We previously reported the results of a randomized controlled trial that found no benefit of vertebroplasty over a sham procedure for acute osteoporotic vertebral fractures up to 6 months. We report here the 12-month and 24-month clinical outcomes of this trial. Eligible participants (n = 78) were randomly assigned to receive either ...
Wang R R Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinA. - - 2014
This study aimed to examine the mechanism of Tα146-162-iMDC in the pathogenic intervention of mice with experimental autoimmune myasthenia gravis (EAMG) from the perspective of B-cell activation. The mice were divided into three groups, model (A), intervention (B), and control (C), with the intervention of Tα146-162-iMDC. The expressions of Cbl-b ...
Ozgurhan Engin Bilge - - 2014
Objective: The objective of the following study is to compare the conjunctival graft thickness measured with anterior segment optical coherence tomography (OCT) after primary and recurrent pterygium excision. Design: Prospective, interventional and comparative study. Participants: A total of 20 eyes of 20 patients with primary pterygium (primary group) and 20 ...
Morris Rk R University of Birmingham, Birmingham, - - 2014
Describe the influences on decision making in fetal lower urinary tract obstruction (LUTO) and identify prenatal prognostic features. The PLUTO study included a registry of cases of isolated LUTO with conservative management or vesicoamniotic shunting (VAS). Logistic regression analysis examined prognostic features affecting outcome. For comparison of effectiveness the outcomes ...
Jairath V V Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, - - 2014
Gastrointestinal (GI) bleeding is a common medical emergency and an important cause of morbidity and mortality in high, middle and low income countries. Despite advances in resuscitative, pharmacological and endoscopic therapy, re-bleeding occurs in 10% of patients with non-variceal bleeding and up to 25% of those with variceal bleeding and ...
Steed H H Gastroenterology, University Hospital North Staffordshire, Stoke-on-Trent, - - 2014
Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive procedure involving heavy sedation. Use of propofol as sedation in ERCP has been demonstrated to be safe, but is it preferred by patients? A prospectively collected dataset of patient satisfaction questionnaires post ERCP, using a Likehart scale. Patients excluded were those who declined ...
Clark L-L LL Gastroenterology, Victoria Infirmary Glasgow, Glasgow, - - 2014
Barrett's oesophagus is a common condition found in 4% of patients undergoing upper gastrointestinal endoscopy.((1)) The association between Barrett's oesophagus and oesophageal adenocarcinoma has been well established. Scotland has a particularly high incidence of both Barrett's and adenocarcinoma of the oesophagus. The risk of progression from high grade dysplasia (HGD) ...
Jairath V V Translational Gastroenterology Unit, Oxford, - - 2014
Transfusion thresholds for upper gastrointestinal bleeding (UGIB) are controversial. Observational studies suggest associations between liberal red blood cell (RBC) transfusion and adverse outcome, and a recent trial reported increased mortality following liberal transfusion. Pragmatic cluster randomised trial to evaluate the feasibility and safety of implementing a restrictive (transfusion when haemoglobin ...
Alam Sm S Gastroenterology, Royal Liverpool and Broadgreen University Hospital Liverpool UK, Liverpool, - - 2014
National guidelines for the management of upper gastrointestinal (GI) bleeding exist and are based on conclusive evidence for effective clinical practice([1].) A mortality rate in acute admissions of 7% was reported in a national audit of upper GI bleeding([2].) This is an area of high volume, high risk and high ...
Shabbir S S Gastroenterology, University Hospital of South Manchester, Manchester, - - 2014
Malnutrition remains an important and common problem in cystic fibrosis (CF) patients and weight loss associated with poor lung function is considered a predictor of mortality, although weight loss has also been found to be an independent predictor of mortality (1,2). Our aim was to compare changes in weight and ...
Rajasekhar Pt P Gastroenterology, Freeman Hospital, Newcastle, - - 2014
High quality colonoscopy prevents colorectal cancers. Low adenoma detection rates (ADR) are linked to subsequent high interval cancer rates. Variability in ADR exists between practitioners. Withdrawal time of >6 min, Buscopan use, position change and rectal retroflexion have some evidence to improve lesion detection. Implementation of evidence based 'bundles' of ...
Goel A A Gastroenterology, Blackpool Teaching Hospitals NHS Trust, Blackpool, - - 2014
SEMS is an accepted palliation for dysphagia in patients with oesophageal cancer. Endoscopic technique (ET) for SEMS insertion has previously been shown to be safe, effective, less time consuming with improved positioning especially of the proximal end of the stent. The obvious limitation of ET is in non-traversable tumours (with ...
Villafañe Jorge H JH IRCCS Don Gnocchi Foundation, - - 2014
[Purpose] The aim of this study was to determine changes in pressure sensitivity and pinch strength in patients with thumb carpometacarpal (CMC) osteoarthritis (OA) in the contralateral hand after unilateral Kaltenborn mobilization on the symptomatic hand. [Subjects and Methods] Twenty-nine females with dominant hand thumb CMC osteoarthritis participated (age 70-90), ...
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