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Muhanguzi Dennis D Department of Biomolecular and Biolaboratory Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Kampala, Uganda; Division of Pathway Medicine, Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United - - 2014
African trypanosomes constrain livestock and human health in Sub-Saharan Africa, and aggravate poverty and hunger of these otherwise largely livestock-keeping communities. To solve this, there is need to develop and use effective and cheap tsetse control methods. To this end, we aimed at determining the smallest proportion of a cattle ...
Thriemer Kamala K Institute of Tropical Medicine, Antwerp, Belgium kthriemer@itg.be - - 2014
Reduced susceptibility of Plasmodium falciparum towards artemisinin derivatives has been reported from the Thai-Cambodian border and from the Thai-Myanmar border. Following increasing reports from central Vietnam of delayed parasite clearance after treatment with dihydroartemisinin-piperaquine (DHA-PPQ), the current first line treatment, a study on the efficacy of this treatment was carried ...
Polat Erdal E İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye. - - 2014
The aim of the study was to treatment of cutaneous leishmaniasis caused by meglumine antimoniate resistant Leishmania major with Lucilia sericata larvae. Samples obtained from patients'lesions were stained with Giemsa and examined under the microscope. The samples were also incubated to Novy-Nicolle-McNeal (NNN) and Roswell Park Memorial Institute (RPMI) 1640 ...
Røder Martin Andreas - - 2013
Background. The Danish attitude for diagnosis and treatment of early localized prostate cancer (PCa) has historically been conservative. Denmark introduced radical prostatectomy (RP) as the last of the Nordic countries in 1995. However, a rapid increment in the Danish incidence of PCa is indicative of a shift in attitude with ...
Aldeen Amer Z - - 2013
Introduction Police officers often serve as first responders during out-of-hospital cardiac arrests (OHCA). Current knowledge and attitudes about resuscitation techniques among police officers are unknown. Hypothesis/problem This study evaluated knowledge and attitudes about cardiopulmonary resuscitation (CPR) and automated external defibrillators (AEDs) among urban police officers and quantified the effect of ...
Hazar Leyla L *Eye Department, K\x{0131}z\x{0131}ltepe Hospital, Mardin, Turkey †Beyoglu Eye Research and Training Hospital, İstanbul, Turkey ‡Eye Department, Batman Hospital, Batman, - - 2013
To report a case with reactivation of toxoplasma choroiretinitis after pars plana vitrectomy. A 58-year-old female patient was diagnosed with secondary epiretinal membrane in her right eye. Bimanual 23-gauge pars plana vitrectomy and membrane peeling was performed. At first week postoperatively, visual acuity decreased; in slit-lamp examination, there were 3+ ...
Ichikawa Kengo - - 2012
PURPOSES: The long-term outcomes of branched-chain amino acids (BCAA) administration after hepatic resection in patients with hepatocellular carcinoma (HCC) remain unclear. This study assessed the effect of oral supplementation with BCAA on the development of liver tumorigenesis after hepatic resection in HCC patients. METHODS: Fifty-six patients were randomly assigned to ...
Luca Angelo - - 2012
To define the natural course of extrahepatic nonmalignant partial portal vein thrombosis (PVT), including the progression from partial to complete PVT, in patients with cirrhosis who had undergone multidetector computed tomography (CT). This study was institutional review board and ethics committee approved. Written informed consent was obtained for each procedure. ...
Goda Taro - - 2012
PURPOSE: To clarify the significance of intrahepatic cystic lesions (ICLs) after Kasai procedure for biliary atresia (BA), we reviewed the BA patients with special reference to the shape of ICLs. METHODS: For the last two decades, 75 cases have been followed up at our institution. The patients were divided into ...
Melloul Emmanuel - - 2012
BACKGROUND: Impairment of clotting factors after liver resection (LR) is considered to protect from the risk of pulmonary embolism (PE). We aimed to formally investigate the risk of PE after elective LR. METHODS: From 2007 to 2009, 410 consecutive patients were prospectively analyzed to assess the risk of postoperative PE ...
Park Hana - - 2012
: Liver stiffness measurement (LSM) using transient elastography (FibroScan) is influenced by major changes in aminotransferase. We aimed to determine the optimal time for restoring the reliability of LSM for assessing liver fibrosis in patients with chronic hepatitis B experiencing acute exacerbation. : Twenty-one patients with acute exacerbation of chronic ...
Takeyasu Makiko - - 2012
The aims of this study were to evaluate the efficacy of long-term interferon (IFN) monotherapy on hepatocellular carcinoma (HCC) in patients who showed no virological response to the first course of IFN therapy, define predictive factors for HCC in patients on long-term IFN monotherapy, and evaluate the clinical impact of ...
Qiu Zhi-Quan - - 2012
Caudate lobectomy has long been considered technically difficult. This study aimed to elaborate the significance of early control of short hepatic portal veins (SHPVs) in isolated hepatic caudate lobectomy or in hepatic caudate lobectomy combined with major partial hepatectomy, and to describe the anatomical characteristics of SHPVs. The data of ...
Papastergiou Vasilios - - 2012
Hepatitis C virus genotype 4 (HCV-4) is spreading beyond Africa and the Middle East but data regarding treatment with pegylated interferon alpha and ribavirin of European populations infected with HCV-4 remains limited. Interestingly, European (vs. Egyptian) origin has been associated with lower sustained virological response rates. Hence the aim of ...
Eechoute Karel - - 2012
PURPOSE: Imatinib minimal (trough) plasma concentrations after 1 month of treatment have shown a significant association with clinical benefit in patients with gastrointestinal stromal tumors (GIST). Considering a retrospective pharmacokinetic (PK) analysis has also suggested that imatinib clearance increases over time in soft tissue sarcoma and GIST patients, the primary ...
Shi Xiao-Lei XL Department of Hepatobiliary Surgery, Jiangsu Province's Key Medical Center for Hepatobiliary Disease, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, - - 2012
To evaluate the efficacy and safety of a hybrid bioartificial liver (HBAL) system in the treatment of acute liver failure. Canine models with acute liver failure were introduced with intravenous administration of D-galactosamine. The animals were divided into: the HBAL treatment group (n = 8), in which the canines received ...
Bertuzzo Valentina Rosa - - 2012
BACKGROUND AND AIMS: The management of patients treated for hepatitis C recurrence after liver transplantation and not achieving virological response following treatment with interferon plus ribavirin is controversial. METHODS: A retrospective analysis of the outcomes of 70 patients non-responders to antiviral treatment after liver transplantation was performed. Twenty-one patients (30.0%; ...
Glinoer Daniel - - 2012
PURPOSE OF REVIEW: To bring to the attention of healthcare professionals the additional information on propylthiouracil (PTU)-related hepatotoxicity, based on a reanalysis of medical files reported to the Food and Drug Administration (1982-2008) for acute liver failure in PTU-treated hyperthyroid patients, and propose recommendations for the clinical use of PTU. ...
Hou Feng-Qin - - 2012
We investigated clinical features, therapy, and outcomes of patients hospitalized for drug-induced liver injury (DILI). DILI resolution was defined as liver biochemistry values back to normal or lower than CIOMS laboratory criteria; Chronicity was defined as persistent biochemical abnormality for >6 months after drugs' withdrawal. Three-hundred cases were reviewed retrospectively; mean ...
Malnick Stephen - - 2012
Autoimmune hepatitis is an immune-mediated disease targeting hepatocytes. It is more common in middle-aged Caucasian females, although may affect other patient populations and age groups. The diagnosis is made according to criteria based on the alkaline phosphatase: ALT ratio, IgG, the presence of autoantibodies, liver histology, response to therapy, and ...
Goel Rajat - - 2012
BACKGROUND: This study aimed to evaluate differences between three methods of liver retraction during laparoscopic Roux-en-Y Gastric bypass (LRYGB) and to compare novel liver retraction techniques with the traditional mechanical liver retractor in a randomized controlled trial. METHODS: In this study, 60 obese patients (26 males and 34 females) who ...
Hogan Marie C MC Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA. - - 2012
We showed in a randomized double-blinded placebo-controlled clinical trial that octreotide long-acting repeatable depot.® (OctLAR(®)) for 12 months reduces kidney and liver growth in autosomal dominant polycystic kidney patients with severe polycystic liver disease (PLD) and liver growth in patients with severe isolated PLD. We have now completed an open-label ...
Tralhao José Guilherme - - 2012
Background/Aims: To investigate the impact of liver resection on the perioperative hepatic function by evaluation of ICG-clearance. Methodology: Twenty-five patients underwent major hepatic resection (Group A) and 36 underwent minor hepatic resection (Group B). Thirteen patients who received no liver surgery, acted as control group (Group C). ICG-clearance measured by ...
Chen Yong-Liang - - 2012
Hilar cholangiocarcinoma is a malignant tumor that is difficult to cure. BACKGROUNDThe aim of this study was to observe the effects of flow-controlled partial portal vein arterializations (PPVA) on liver regeneration after hepatectomy in minipigs with chronic obstructive jaundice. Eight minipigs were made into chronic obstructive jaundice models. United semi-hepatectomy, ...
Olmez A - - 2012
The objective of this study was to compare harmonic scalpel for short hepatic vein transection with conventional ligation during recipient hepatectomy with caval preservation. Sixteen patients undergoing elective living donor liver transplantation were randomized into 2 groups. We recorded number, diameter, and location of each short hepatic vein, procedure time, ...
Siriwardana Rohan C - - 2012
Liver regeneration that occurs after portal vein embolization (PVE) may have adverse effects on the microscopic tumor foci in the residual liver mass in patients with hepatocellular carcinoma (HCC). Fifty-four HCC patients with inadequate functional residual liver volume were offered PVE during a seven-year period. Among them, 34 (63%) patients ...
Wang Mao Qiang - - 2012
BACKGROUND: Surgical therapy for symptomatic polycystic liver disease (PLD) is effective but has substantial mortality and morbidity. Minimally invasive options such as laparoscopic fenestration, percutaneous cyst aspiration with or without injection of a sclerosing solution have had disappointing results. Because the hepatic cysts in autosomal dominant polycystic kidney disease (ADPKD) ...
Lock Johan Friso - - 2012
BACKGROUND: The regenerative capacity of the liver is an essential pre-condition for the successful application of partial hepatectomy. However, the actual kinetics of functional recovery remains unspecified and no adequate tool for its clinical monitoring has yet been available. METHODS: Eighty-five patients receiving major hepatectomy were investigated from the preoperative ...
Qiu Yudong - - 2012
OBJECTIVE: This study was designed to analyze the feasibility of classification for hepatic veins preoperatively and to evaluate the safety and therapeutic efficacy of precise hemihepatectomy guided by middle hepatic vein. METHODS: Thirty patients who underwent precise hemihepatectomy (PH group) were subjected to multi-slice helical CT hepatic venography preoperatively to ...
Kele P G - - 2012
BACKGROUND: The liver is known to regenerate following partial hepatectomy (PH), but little is known about the timing and completeness of regeneration relative to the resected volume. This study examined whether liver volume regeneration following PH and its completeness 6 months after surgery is related to the resected volume. METHODS: ...
Lee I J - - 2012
This study was designed to evaluate the extent of the radiofrequency ablation zone in relation to the time interval between transcatheter arterial embolisation (TAE) and radiofrequency ablation (RFA) and, ultimately, to determine the optimal strategy of combining these two therapies for hepatocellular carcinoma. 15 rabbits were evenly divided into three ...
Wang Shu-Bin - - 2012
The natural history of liver cirrhosis in China has not been well understood. This study aimed to elucidate the profile and development of the complications of liver cirrhosis as well as the mortality of those cirrhotics with miscellaneous complications. We assembled data from the clinical characteristics, especially from the profile ...
Okada Masahiro - - 2012
Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to ...
Zhou Jin - - 2012
BACKGROUND: Hypersplenism is a common clinical manifestation in patients with liver cirrhosis. For treatment, surgeons can choose between two options: open splenectomy (OS) or laparoscopic splenectomy (LS). Although splenectomy has wide exposure and acceptance as a remedy for the patients with hypersplenism secondary to liver cirrhosis, the data are sparse ...
Honda Koichi K First Department of Internal Medicine, Oita University, Oita 879-5593, Japan. - - 2012
A 69-year-old man was admitted to our hospital in October 2003, for further examination of two liver tumors. He was diagnosed with hepatocellular carcinoma (HCC) arising from decompensated hepatitis B virus (HBV)-related cirrhosis. Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC. His Child-Pugh score was 9 ...
van Lienden Krijn P - - 2012
PURPOSE: Alternative methods to optimize the hypertrophy response after portal vein embolization (PVE) are desired. This study assessed the effect of hepatic vein embolization (HVE) in addition to PVE on liver hypertrophy response in a standardized rabbit model. MATERIALS AND METHODS: Thirty rabbits were allocated to groups according to intervention: ...
Iida Hiroya H Department of Surgery, Meiwa Hospital 4-31 Agenaruo-cho, Nisinomiya, Hyogo 663-8186, Japan. - - 2012
To compare the effect of percutaneous transhepatic portal vein embolization (PTPE) and unilateral portal vein ligation (PVL) on hepatic hemodynamics and right hepatic lobe (RHL) atrophy. Between March 2005 and March 2009, 13 cases were selected for PTPE (n = 9) and PVL (n = 4) in the RHL. The ...
Grant Krystan R - - 2012
Southern stingrays, Dasyatis americana, are a well-represented elasmobranch species in public aquaria and other facilities throughout the world. This study was conducted at a facility that experienced some mortality and replenished the collection with wild-caught stingrays. A common necropsy finding among the stingrays was a small, dark liver. The objectives ...
Shigefuku Ryuta - - 2012
INTRODUCTION: Effective noninvasive tests that can distinguish early-stage nonalcoholic steatohepatitis (NASH) from simple steatosis (SS) have long been sought. Our aim was to determine the possibility of noninvasively distinguishing early-stage NASH from SS. MATERIALS AND METHODS: We used Fick's principle and the Kety-Schmidt equation to determine the hepatic tissue blood ...
Hegazy Sahar K SK Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta 8130, Egypt. - - 2012
To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver fibrosis. Aloe vera high molecular weight fractions (AHM) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray radiation. Fifteen healthy volunteers as the control group and 40 patients were ...
Jin Fangli - - 2012
Aim: Analysis of the efficacy and timing of plasma exchange (PE) in the treatment of acute fatty liver of pregnancy (AFLP). Methods: The clinical data of 39 cases of AFLP treated with PE from September 2004 to March 2011 include symptoms, physical signs, adverse effects, and all relevant laboratory test ...
Melloul Emmanuel - - 2012
BACKGROUND: As a consequence of the increase in life expectancy, hepatobiliary surgeons have to deal with an emerging aged population. We aimed to analyze the liver function and outcome after right hepatectomy (RH) in patients over 70 years of age. METHODS: From January 2006 to December 2009, we prospectively collected data ...
Qian Guo-Jun - - 2012
OBJECTIVE: To prospectively compare microwave (MW) ablation using a modified internal cooled-shaft antenna with radiofrequency (RF) ablation in in vivo porcine liver and in patients with small hepatocellular carcinoma (sHCC). METHODS: In an animal study, MW and RF ablations using a cooled-shaft antenna or internally cooled electrode were performed in ...
Huang Yu-Kun - - 2012
Background/Aims: To evaluate the use of plasma exchange (PE) combined with the molecular adsorbent re-circulating system (MARS) for the treatment of liver failure complicated with hepatic encephalopathy. Methodology: A prospective randomized controlled study was conducted to compare the therapeutic effect of MARS treatment (MARS group, n=60) with that of PE ...
Boleslawski E - - 2012
BACKGROUND: Preoperative measurement of hepatic venous pressure gradient (HVPG) is not performed routinely before hepatectomy in patients with cirrhosis, although it has been suggested to be useful. This study investigated whether preoperative HVPG values and indirect criteria of portal hypertension (PHT) predict the postoperative course in these patients. METHODS: Between ...
Ge Yong-Sheng - - 2012
Background/Aims: Radiofrequency ablation (RFA) is a new treatment which is used to treat hepatocellular carcinoma (HCC). We performed this clinical trial to investigate whether it could reduce the damage of residual liver function. Methodology: We studied 40 hepatitis-related chronic patients who underwent RFA for hepatocellular carcinoma. Indocyanine green (ICG) test ...
Stamp Gregory Francis William - - 2012
AIM: To investigate whether in lower extremity lymphoedema, lymph proteins enter blood before they do the thoracic duct. METHODS: Retrospective analysis of routine lymphoscintigraphy in 69 adults imaged at 5, 45 and 150 min following bilateral subcutaneous web space injection of Tc-nanocolloid was carried out. Regions of interest were placed ...
Czaja Albert J - - 2012
Current treatment strategies for autoimmune hepatitis are complicated by frequent relapse after drug withdrawal, medication intolerance, and refractory disease. The objective of this review is to describe advances that have improved treatment outcomes by defining the optimum objectives of initial therapy, managing relapse more effectively, identifying problematic patients early, and ...
Rosemurgy Alexander S - - 2012
Widespread application of transjugular intrahepatic portasystemic shunt (TIPS) continues despite the lack of trials documenting efficacy superior to surgical shunting. Here we present an 18-year follow-up of a prospective randomized trial comparing TIPS with small-diameter prosthetic H-graft portacaval shunt (HGPCS) for portal decompression. Beginning in 1993, patients were prospectively randomized ...
Kim H - - 2012
Thrombocytopenia (platelet < 60,000/mm(3)) and uncontrolled massive ascites (ascitic fluid > 1000 mL/d over 10 days) after liver transplantation (OLT), although uncommon, usually represent serious complications. Splenectomy is a useful treatment despite its many side effects. Recently, partial splenic artery embolization (PSAE) is considered to be a nonsurgical, less invasive ...
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