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Barbato Emanuele - - 2014
Aims: To report the six-month angiographic and two-year clinical outcome data from the first-in-man study with the Ultimaster DES, a thin-strut cobalt-chromium sirolimus-eluting stent (SES) with an innovative abluminal-gradient-coated bioresorbable polymer. Methods and results: CENTURY is a multicentre, single-arm, prospective study that enrolled 105 patients (113 lesions) with coronary artery ...
White Christopher J CJ Department of Medicine, Ochsner Clinical School, John Ochsner Heart & Vascular Institute, New Orleans, Louisiana. Electronic address: - - 2014
Carotid artery stenting (CAS) has achieved clinical equipoise with carotid endarterectomy (CEA), as evidenced by 2 large U.S. randomized clinical trials, multiple pivotal registry trials, and 2 multispecialty guideline documents endorsed by 14 professional societies. The largest randomized trial conducted in patients at average surgical risk of CEA, CREST (Carotid ...
Thomas Dustin D Cardiology Service, Brooke Army Medical Center, San Antonio, TX, - - 2014
Abdominal aortic aneurysm (AAA) is common with unacceptably high rates of mortality and morbidity with unknown rates of complications after repair in the Department of Defense (DoD). All patients treated at a DOD or VA clinic or medical facility with a diagnosis of AAA identified by ICD-9 code search were ...
Elder Robert W RW Section of Cardiology, Pediatrics and Internal Medicine, Yale School of Medicine, New Haven, Conn, - - 2014
Risk factors for major adverse events late after Fontan palliation are unknown. Prior studies have suggested ventricular function and morphology as important risk factors. The aim of this study is to (1) characterize the late major adverse event profile in adult Fontan patients and (2) identify additional risk factors that ...
Di Pascoli Lorenza L Lorenza Di Pascoli, Massimo Bolognesi, Sara Montagnese, Angelo Gatta, Carlo Merkel, Hepatic Hemodynamic Laboratory and Clinica Medica 5, Department of Medicine, University of Padua, 35128 Padova, - - 2014
To evaluate the most cost-effectiveness strategy for preventing variceal growth and bleeding in patients with cirrhosis and small esophageal varices. A stochastic analysis based on decision trees was performed to compare the cost-effectiveness of beta-blockers therapy starting from a diagnosis of small varices (Strategy 1) with that of endoscopic surveillance ...
Gonzalez Maday M Department of Medicine, Division of Cardiology, Weill Cornell Medical College, New York, NY - - 2014
Subclinical atrial high rate episodes (AHREs) detected by implanted devices in patients without prior history of atrial fibrillation (AF) have been associated with an increased risk of stroke and systemic embolism. Data regarding the long-term survival of patients with permanent pacemakers and newly detected AHREs are limited. To assess whether ...
Gandolfi Marialuisa M Neuromotor and Cognitive Rehabilitation Research Centre (CRRNC), Department of Neurological and Movement Sciences, University of Verona, Verona, Italy, - - 2014
Stroke is a major cause of dysphagia. Few studies to date have reported on standardized multidisciplinary protocolized approaches to the management of post-stroke dysphagia. The aim of this retrospective cohort study was to evaluate the impact of a standardized multidisciplinary protocol on clinical outcomes in patients with post-stroke dysphagia. We ...
Kim Luke K LK From the Division of Cardiology, Weill Cornell Medical College, New York Presbyterian Hospital (L.K.K., D.C.Y., R.V.S., R.M.M., P.M.O., S.C.W., G.B., H.S., D.N.F.); Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA (M.K.L.); Division of Biostatistics and Epidemiology, Department of Public Health, Weill Medical College of Cornell University, New York, NY (X.S.); Department of Cardiovascular Medicine, Pennsylvania Hospital-University of Pennsylvania Health System, Philadelphia (D.J.M.); and Department of Orthodontics College of Dentistry, University of Iowa, Iowa City (V.A.). - - 2014
Given the controversy regarding whether carotid endarterectomy (CEA) or carotid artery stenting (CAS) may be superior for stroke prevention, it is uncertain how recent clinical evidence, guidelines, and reimbursement policies have influenced the volume and outcomes after these procedures. We conducted a serial, cross-sectional study with time trends of patients ...
Hansen Morten M Department of Cardiology, Odense University Hospital, Odense, - - 2014
Objectives: Seven years ago, the DanCell study was carried out to test the hypothesis of improvement in left ventricular ejection fraction (LVEF) following repeated intracoronary injections of autologous bone marrow-derived stem cells (BMSCs) in patients suffering from chronic ischemic heart failure. In this post hoc analysis, the long-term effect of ...
Wijns William W Cardiovascular Center, OLV Hospital, Aalst, - - 2014
To compare the long-term clinical safety between two drug-eluting stents with different healing characteristics in the Patient Related Outcomes with Endeavour (E-ZES) vs. Cypher (C-SES) Stenting Trial (PROTECT). At 3 years, there was no difference in the primary outcome of definite or probable stent thrombosis or in the other main ...
Cassese Salvatore S Deutsches Herzzentrum, Technische Universität München, Munich, - - 2014
Aims: Current recommendations on the use of bivalirudin in patients treated with percutaneous coronary intervention (PCI) are mostly based on trials comparing bivalirudin versus heparin plus planned glycoprotein IIb/IIIa inhibitor (GPI). Whether bivalirudin is also superior to heparin alone is still not well established. This meta-analysis investigates the efficacy and ...
Andrew E E Ambulance Victoria, Melbourne Australia; Monash University, Melbourne Australia. Electronic address: - - 2014
While internationally reported survival from out-of-hospital cardiac arrest (OHCA) is improving, much of the increase is being observed in patients presenting to emergency medical services (EMS) in shockable rhythms. The purpose of this study was to assess survival and 12-month functional recovery in patients presenting to EMS in asystole or ...
Chen Guohai G *Department of Ophthalmology, Quzhou People's Hospital, Quzhou, China; †Xiamen Eye Center of Xiamen University, Xiamen, China; ‡The Roskamp Institute, Sarasota, Florida; and §Department of Ophthalmology, University of South Florida, Tampa, - - 2014
To evaluate the relative efficacy and safety of bevacizumab versus ranibizumab for the treatment of the neovascular form of age-related macular degeneration. A comprehensive literature search using the Cochrane Methodology Register to identify randomized controlled trials comparing bevacizumab with ranibizumab in patients with neovascular age-related macular degeneration. Efficacy estimates were ...
Vaughan Sarrazin Mary S MS Comprehensive Access and Delivery Research and Evaluation Center (CADRE), Iowa City VA Medical Center, Iowa City, IA 52246; Department of Internal Medicine, Roy and Lucille J. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242. Electronic address: - - 2014
Clinical trial data suggest that dabigatran and warfarin have similar rates of major bleeding but higher rates of gastrointestinal bleeding. These findings have not been evaluated outside of a clinical trial. Evaluate the relative risks of any, gastrointestinal, intracranial, and other bleeding for VA patients who switched to dabigatran after ...
Mehta Manish M Department of Vascular and Endovascular Surgery, Albany Medical College, Albany, NY. Electronic address: - - 2014
Endovascular treatment of abdominal aortic aneurysm (AAA) is associated with benefits over open surgery, yet limitations remain with current endovascular devices. This study was performed to assess outcomes of AAA repair with the Aptus endograft and EndoAnchors (Aptus Endosystems, Sunnyvale, Calif). This prospective, multicenter, single-arm investigational device exemption trial was ...
Li Yi Y Medical Informatics Center, Peking University, Beijing, 100191, - - 2014
To evaluate the cost-effectiveness of combining Chinese medicine (CM) with Western medicine (WM) for ischemic stroke patients. Hospitalization summary reports between 2006 and 2010 from eight hospitals in Beijing were used to analyze the length of stay (LOS), cost per stay (CPS), and outcomes at discharge. Among 12,009 patients (female, ...
Stathopoulos Ioannis I Lenox Hill Hospital, Heart and Vascular Institute of New York, Department of Cardiac and Vascular Interventional Services, New York, New York, USA. - - 2014
Guidewire-induced coronary perforation (CP) rate is reported to have increased. We analyzed 23,399 PCIs and identified 73 patients complicated by CP, of which 31 were guidewire induced. Patients were divided into two groups: group A (guidewire-induced CP) and group B (non-guidewire induced CP). Characteristics and outcomes were compared and a ...
Bellizzi Vincenzo V Division of Nephrology, Dialysis and Renal Transplantation, 'San Giovanni di Dio e Ruggi d'Aragona' University Hospital of Salerno, Salerno, - - 2014
Very low-protein intake during chronic kidney disease (CKD) improves metabolic disorders and may delay dialysis start without compromising nutritional status, but concerns have been raised on a possible negative effect on survival during dialysis. This study aimed at evaluating whether a very low-protein diet during CKD is associated with a ...
Tsutsumi Joshi J Division of Cardiology, Saitama Cardiovascular Respiratory Center, 1696 Itai, Kumagaya, Saitama, 360-0197, - - 2014
We conducted a retrospective comparison of the long-term clinical and angiographic outcomes of 281 consecutive nonrandomized severely calcified lesions in 221 patients treated with a sirolimus-eluting stent (SES; CYPHER Bx VELOCITY) or a paclitaxel-eluting stent (PES; TAXUS Express) placed after rotablation between August 2004 and February 2009. The clinical safety ...
Tisherman Samuel A SA *University of Maryland, Baltimore, MD †University of Washington, Seattle, WA ‡Medical College of Wisconsin, Milwaukee, WI §University of Alabama at Birmingham, Birmingham, AL ¶University of Texas Southwestern Medical Center, Dallas, TX ∥St Michael's Hospital, Toronto, ON, Canada **Oregon Health and Science University, Portland, - - 2014
To identify causes and timing of mortality in trauma patients to determine targets for future studies. In trials conducted by the Resuscitation Outcomes Consortium in patients with traumatic hypovolemic shock (shock) or traumatic brain injury (TBI), hypertonic saline failed to improve survival. Selecting appropriate candidates is challenging. Retrospective review of ...
Her Ae-Young AY Division of Cardiology, Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, South - - 2014
We sought to investigate the effect of ward-to-cath lab blood pressure (BP) differences on long-term clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). There are limited data available on the association between PCI with DES and BP differences on long-term clinical outcomes. This study enrolled ...
Bangalore Sripal S New York University School of Medicine, New York, - - 2014
Background: The safety of drug eluting stents (DES) vs. bare metal stents (BMS) in the perioperative setting, a heightened state of inflammation and thrombosis is not well defined. Methods: All adults undergoing NCS within 1 year following percutaneous coronary intervention (PCI) in Massachusetts between April 1, 2004 and September 30, ...
Ieguchi Makoto M Department of Orthopedic Surgery, Yodogawa Christian Hospital, Osaka - - 2014
Extra-articular resection is necessary to obtain a wide margin for primary osteosarcomas invading the knee joint, and the limb is often reconstructed using a prosthesis. Here, outcomes of extra-articular and intra-articular procedures were compared. Between 1999 and 2012, 14 patients with osteosarcoma underwent extra-articular excision (n = 6; ages 23-65 ...
Lund Lars H LH Karolinska Institutet, Department of Medicine, Stockholm, Sweden; Karolinska University Hospital, Department of Cardiology, Stockholm, - - 2014
The prevalence of cardiovascular and non-cardiovascular co-morbidities and their relative importance for outcomes in heart failure with preserved ejection fraction (HFPEF) remain poorly characterized. This study aimed to investigate this. The Karolinska-Rennes (KaRen) Study was a multinational prospective observational study designed to characterize HFPEF. Inclusion required acute HF, defined by ...
Savage Stephanie A SA From the Division of Trauma & Critical Care, University of Tennessee Health Science Center, Memphis, - - 2014
The practice of 1:1 transfusion, administering packed red blood cells (PRBCs) with fresh frozen plasma (FFP), has been associated with improved survival. However, the reported ratios are the result of mathematical averages over 24 hours and do not necessarily represent concurrent administration. Using critical administration thresholds (CAT+) of more than ...
Qian Jie J Department of Cardiology, FuWai Hospital, National Center for Cardiovascular Diseases, Beijing, - - 2014
Aims: To compare stent strut coverage using optical coherence tomography (OCT) at three-month follow-up between a PLGA-polymer with electro-grafting base layer sirolimus-eluting stent (SES) (BuMA) and a PLA-polymer SES (EXCEL). Methods and results: This prospective, single-centre, non-inferiority randomised BuMA-OCT trial enrolled patients with de novo coronary artery lesions, treated with ...
Dattolo Pietro P Nephrology and Dialysis Unit, SM Annunziata Hospital, Florence, Italy, - - 2014
The optimal timing of dialysis initiation is still unclear. We aimed to ascertain whether a strict clinical follow-up can postpone need for dialysis in chronic kidney disease (CKD) stage 5 patients. We reviewed records of all consecutive adult patients attending our conservative CKD stage 5 outpatient clinic from 2001 to ...
Kotani Yasuhiro Y Division of Cardiovascular Surgery, The Labatt Family Heart Centre, The Hospital for Sick Children Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, - - 2014
We sought to evaluate the medium-term implications of fenestration status. Between 1994 and 2012, 326 patients received an extracardiac Fontan (hospital mortality n = 6, 1.8%). A fenestration was routinely created (n = 306, 94%) unless there was technical difficulty. Three hundred patients discharged with an open fenestration were included. The primary end points ...
Lee Melissa G Y MG Department of Cardiac Surgery, The Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia; Murdoch Childrens Research Institute, Melbourne, Victoria, - - 2014
The purpose of this study was to determine the rate of reinterventions from birth to adulthood after end-to-side anastomosis technique for interrupted and hypoplastic aortic arches. Multicenter data have shown that more than half of patients require arch reintervention in the 2 decades after repair. The follow-up of 170 consecutive ...
Conrad Mark F MF Division of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Mass. Electronic address: - - 2014
Although level 1 evidence supports carotid endarterectomy (CEA) for stroke prevention in patients with asymptomatic severe carotid artery stenosis (ASCAS; >70%), medical therapy alone has been promulgated by some as equally effective. The goal of this study was to determine the natural history of medically treated patients with ASCAS. Patients ...
Klintmalm G B GB Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, - - 2014
This exploratory phase II study evaluated the safety and efficacy of belatacept in de novo adult liver transplant recipients. Patients were randomized (N = 260) to one of the following immunosuppressive regimens: (i) basiliximab + belatacept high dose [HD] + mycophenolate mofetil (MMF), (ii) belatacept HD + MMF, (iii) belatacept low dose [LD] + MMF, (iv) tacrolimus + MMF, or (v) tacrolimus ...
Généreux Philippe P Columbia University Medical Center and Cardiovascular Research Foundation, New York, NY, - - 2014
Aims: We sought to describe the incidence, predictors, and impact of adverse neurological events (NE) in a non-ST-segment elevation acute coronary syndromes (NSTEACS) population undergoing percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or medical therapy (MT). Methods and results: 13,819 patients with moderate and high-risk NSTEACS were enrolled ...
Svensson Lars G LG Cleveland Clinic, Cleveland, Ohio; PARTNER Publication Office, New York, New York, and Cleveland, Ohio. Electronic address: - - 2014
Patients with severe aortic stenosis (AS) who were deemed too high risk or inoperable for conventional aortic valve replacement (AVR) in the PARTNER (Placement of Aortic Transcatheter Valves) trial were randomized to transcatheter aortic valve replacement (TAVR) versus AVR (PARTNER-A arm) or standard therapy (PARTNER-B arm). This study compared when ...
Wilcox Robert R Faculty of Medicine & Health Sciences, Cardiovascular Medicine, Nottingham, - - 2014
Abstract Background In TRITON-TIMI 38, patients with acute coronary syndromes were treated with prasugrel or clopidogrel, with acetylsalicylic acid, for a median of 14.5 (maximum of 15) months. Based on this trial, the EU label for prasugrel recommends treatment for up to 12 months and excludes patients with prior stroke/TIA. ...
Bhama Prabhat K PK Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, - - 2014
Background Free tissue transfer is a reliable method for reconstruction of head and neck defects. With the growing number of octogenarians in the population, it is important to understand how these patients respond to these procedures. Methods Through a retrospective chart review of patients who underwent a free-flap reconstruction from 2000 to ...
Heeley Emma L EL The George Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, - - 2014
Antihypertensive drugs are useful in the prevention of stroke; however, much debate surrounds which class of agent provides the most benefit post-stroke. The aim of this study was to examine the impact of different classes of antihypertensive agent on stroke outcome using data from the ChinaQUEST study, a prospective, hospital-based ...
Liu Xue-Hua XH Department of Intensive Care Unit, TianJin People's Hospital , TianJin, China - - 2014
Aim: The aim of this study was to identify whether mannose-binding lectin (MBL) and C-reactive protein (CRP) may be used as clinical biomarkers for predicting outcome of community-acquired pneumonia (CAP) by tracking serum MBL and CRP level changes during a time course. Methods: One hundred four patients with CAP and ...
Shi Guocheng G Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Heart Center, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
Interrupted aortic arch (IAA) is a complicated congenital heart disease requiring an individualized management strategy. We reported the results for surgical repair of IAA with associated anomalies. This was a retrospective review of 119 patients undergoing one-stage biventricular repair of IAA with associated lesions at the median age of 18 ...
Fontana Robert J RJ Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, - - 2014
The long-term clinical outcomes in initial survivors with acute liver failure (ALF) are not well known. The aim of the current study is to provide an overview of the 2 year clinical outcomes amongst initial survivors and liver transplant (LT) recipients that were alive 3 weeks after enrollment in the ...
Hidaka Nobuhiro - - 2014
Abstract Objective: We aimed to investigate the clinical characteristics and postnatal outcomes of fetuses with congenital diaphragmatic hernia (CDH) and additional anomalies. Materials and methods: We reviewed the charts of fetuses with CDH managed between 2005 and 2013. Patients were divided into complex and isolated groups based on the presence ...
Moonesinghe S R SR UCL/UCLH Surgical Outcomes Research Centre, Department of Anaesthetics, University College Hospital, London NW1 2BU, UK UCL Centre for Anaesthesia, University College Hospital, London NW1 2BU, UK National Institute for Academic Anaesthesia's Health Services Research Centre, Royal College of Anaesthetists, 35 Red Lion Square, London WC1R 4SG, UK - - 2014
Previous studies have suggested that there may be long-term harm associated with postoperative complications. Uncertainty exists however, because of the need for risk adjustment and inconsistent definitions of postoperative morbidity. We did a longitudinal observational cohort study of patients undergoing major surgery. Case-mix adjustment was applied and morbidity was recorded ...
Lee Cheol Whan CW Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, - - 2014
We investigated the temporal patterns of drug-eluting stents (DES) failure and its relationship with clinical outcomes in patients with DES failure. Time to DES failure is widely variable, but little information is available on the temporal patterns of DES failure and its impact on clinical outcomes. The angiographic patterns of ...
Wu Cynthia C Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address: - - 2014
The frequency and case fatality of venous thromboembolism (VTE) and major bleeding during the initial 3months of therapy in those treated for symptomatic VTE with either direct oral anticoagulants (DOACs) or vitamin K antagonists (VKA) are important clinically relevant outcomes. We sought to measure it during the initial months of ...
Dvir Danny D St Paul's Hospital, Vancouver, British Columbia, - - 2014
Owing to a considerable shift toward bioprosthesis implantation rather than mechanical valves, it is expected that patients will increasingly present with degenerated bioprostheses in the next few years. Transcatheter aortic valve-in-valve implantation is a less invasive approach for patients with structural valve deterioration; however, a comprehensive evaluation of survival after ...
Kuwaki Hiroshi H Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, - - 2014
This study sought to examine left atrial (LA) mechanics and the prognostic impact of patients with echocardiographic findings of E/A ratio ≤0.75, deceleration time (DcT) of mitral E-wave >140 ms, but E/ε' ≥10. Traditional diastolic dysfunction (DD) grading system could not classify every patient into a specific group. We considered the group ...
Callaghan John J JJ Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01029 JPP, Iowa City, IA, 52242, USA, - - 2014
Long-term evaluation of knee arthroplasty should provide relevant information concerning the durability and performance of the implant and the procedure. Because most arthroplasties are performed in older patients, most long-term followup studies have been performed in elderly cohorts and have had low patient survivorship to final followup; the degree to ...
Speziale Francesco F Vascular and Endovascular Surgery Unit, "Sapienza" University of - - 2014
Endovascular aneurysm repair (EVAR) has fast become the therapeutic strategy of choice for abdominal aortic aneurysms (AAA). Nowadays, the most important limit to the effectiveness of this technique is represented by complex anatomical situations, especially regarding the morphology of the proximal sealing zone. The aim of the present study was ...
Hunt Linda P LP Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, - - 2014
Understanding the risk factors for early death after knee replacement could help to reduce the risk of mortality after this procedure. We assessed secular trends in death within 45 days of knee replacement for osteoarthritis in England and Wales, with the aim of investigating whether any change that we recorded ...
Murakami Hironori H Division of Cardiology, Cardiovascular Center, Teine Keijinkai Hospital, Sapporo, Japan. Electronic address: - - 2014
The prevalence of severe sclerotic aortic stenosis (ScAS) in those at least ≧80 years old has been increasing in Japan; however, the prognosis of these Japanese patients without surgical treatment has not been reported. Ninety consecutive patients with medically treated severe ScAS were prospectively studied. To assess further event-free survival ...
Larsen Jacob M JM Department of Cardiology and Center for Cardiovascular Research, Aalborg University Hospital. Electronic address: - - 2014
Recalled St Jude Medical Riata defibrillator leads are prone to insulation failures with externalized conductors (EC). Longitudinal studies are needed to guide lead management. To describe the dynamic nature of EC and the association with electrical abnormalities and lead extraction outcomes. A nationwide cohort established in 2012 of 295 patients ...
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