BACKGROUND:: Heparin-Induced Thrombocytopenia type II (HIT II) correlates with a higher incidence of thromboembolic complications and unfavorable outcome. OBJECTIVE:: We examined the risk factors and outcomes for patients with HIT II with aneurysmal subarachnoid hemorrhage (aSAH). METHODS:: Demographics, risk factors, treatments, and outcomes data of 600 aSAH patients admitted to ...

Alkan EA, Parlar A. EMD or subepithelial connective tissue graft for the treatment of single gingival recessions: a pilot study. J Periodont Res 2011; doi: 10.1111/j.1600-0765.2011.01381.x. © 2011 John Wiley & Sons A/S Background and Objective:  The combination of EMD with root-coverage procedures has been shown to promote periodontal regeneration ...

The maxillary anterior teeth are the most important to facial esthetics because they are the first to show on a smile. Therefore, stability of the maxillary anterior teeth alignment is an important issue. The objective of this study was to compare the stability of maxillary anterior tooth alignment in Class ...

Our objective was to evaluate the nasal passage (NP) and oropharyngeal (OP) volumes of patients with different dentofacial skeletal patterns. The study sample consisted of 140 patients (70 boys, 70 girls), divided into 3 groups as Class I (1 ≤ANB ≤3), Class II (ANB >3), and Class III (ANB <1), and then further divided into ...

Returning from his pilgrimage to the Holy Land Vesalius encountered serious trouble, as a consequence of which he died on the Greek island Zakynthos. Following a discussion of the circumstances of his death and what is known about his grave, we examine also Vesalius's intentions for the period after his ...

OBJECTIVE: To compare the morbidity of primary skin closure with elective Tensor Fascia Lata (TFL) flap cover in groin dissections. MATERIALS AND METHODS: This was a retrospective study between January 2007 and December 2009. All patients undergoing groin dissections without skin involvement were included. RESULTS: Of the twenty-five patients, who ...

OBJECTIVES:: A biomechanical study was performed to test the hypothesis that a varus deformity of the humeral head decreases supraspinatus (SSP) efficiency and increases deltoid elevation forces in human specimens. METHODS:: Twenty-four fresh-frozen human shoulder specimens were prepared by preserving the rotator cuff and deltoid. A defined, medial closed-wedge osteotomy ...

This retrospective study evaluated the skeletal and soft tissue facial profile changes as well as the predictability and the short-term stability of the soft-tissue response to advancement genioplasty in Class I dental arch relationship patients. The study included 14 adult patients who presented a Class I dental arch but a ...

Pulmonary regurgitation and prolonged QRS duration of right bundle branch (RBB) block are common in repaired tetralogy of Fallot (TOF) and increase the risk of sudden death. We sought to establish an animal model to reflect both abnormalities. Twenty-one canines: group I (n=7) received a surgical right ventricular outflow tract ...

The DeBakey classification was used to discriminate the extent of acute aortic dissection (AD) and was correlated to long-term outcome and re-intervention rate. A slight modification of type II subgroup definition was applied by incorporating the aortic arch, when full resectability of the dissection process was given. Between January 2001 ...

PURPOSE: This study was designed to analyze the effect of two different ablation modes ("temperature control" and "power control") of a microwave system on procedural outcome in porcine kidneys in vivo. METHODS: A commercially available microwave system (Avecure Microwave Generator; MedWaves, San Diego, CA) was used. The system offers the ...

Purpose. To describe the results obtained in patients with neovascular age-related macular degeneration treated with ranibizumab 0.5 mg on an as-needed basis from the start after 1 year of follow-up. Methods. Retrospective, consecutive interventional case series of patients with all angiographic types of neovascular age-related macular degeneration (mean baseline size, ...

The era prior to 1990 was a time of careful observation of disease presentation, course, outcomes and meticulous pathology studies. These mainly single-centre studies introduced new life-saving therapies for drugs still used effectively today. In the 1970-1980s, cyclophosphamide (CyP) added to glucocorticosteroids (GCS) was shown to be life-saving. The trade-off ...

Mild Class III malocciusions can be treated by upper incisor proclination and lower incisor retroclination following extraction of the lower first premolars. To compare the skeletal, dental and soft tissue changes in Class III patients treated with fixed appliances, Class III traction and lower first premolar extractions with the changes ...

To determine the role of intravitreal bevacizumab injected at the time of cataract surgery on postoperative increase of retinal thickness in patients with diabetic retinopathy. Patients were randomized to a standardized procedure of phacoemulsification with intraocular lens implantation alone (control group; 30 eyes) or to receive 1.25 mg intravitreal bevacizumab ...

The purpose of this study was to assess the outcomes of twenty isolated type II SLAP lesions which were repaired arthroscopically using a two-portal technique. Shoulder function was evaluated at a mean follow-up of 2 years using the modified Constant-Murley score. The average preoperative score was 65.2%; it improved postoperatively ...

The muscle imbalance associated with the spastic type of infantile cerebral palsy may result in subluxations or dislocations of the hip. The aim of the study was to compare the clinical and radiological results of myotomy of the hip adductor muscles versus adductor transfer to the ischiadic tuber in the ...

Purpose. To investigate the inflammation of the anterior chamber after intravitreal bevacizumab injection in different ocular exudative diseases. Methods. The study included 76 eyes from 62 consecutive patients with different ocular exudative diseases. The patients were divided into the 3 following groups: group 1 (nonproliferative diabetic retinopathy), group 2 (choroidal ...

To determine whether internal limiting membrane (ILM) peeling is effective and cost effective compared with no peeling in patients with idiopathic stage 2 or 3 full-thickness maculay hole (FTMH). This was a pragmatic multicenter randomized controlled trial. Eligible participants from nine centers were randomized to ILM peeling or no peeling ...

To investigate the cause of visual acuity (VA) loss in patients with neovascular age-related macular degeneration (AMD) receiving monthly ranibizumab injections in the pivotal ranibizumab phase III trials. Retrospective analysis. The Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab In the treatment of Neovascular AMD (MARINA) and Anti-VEGF Antibody for ...

: The purpose of this study was to evaluate whether combined customized photodynamic therapy (PDT) and bevacizumab in myopic choroidal neovascularization can improve vision and whether it is possible to decrease the frequency and number of intravitreal antiangiogenic injections. : A prospective, consecutive, noncomparative, interventional case series of 36 patients ...

Purpose. We prospectively evaluated a new treatment for recalcitrant choroidal neovascularization (CNV) in 4 patients. We used an infrared laser (810 nm) in oscillatory thermotherapy (OTT) mode combined with indocyanine green (ICG) dye, utilizing the beneficial effect of both thermotherapy and photodynamic therapy. We describe preliminary experiences with ICG-assisted OTT ...

Purpose:  This study aimed to evaluate the course of macular sensitivity (MS) following treatment with reduced fluence photodynamic therapy (RPDT) versus standard photodynamic therapy (SPDT) in combination with intravitreal triamcinolone acetonide (IVTA) in patients with neovascular age-related macular degeneration, and to investigate the correlation between MS and angiographic outcomes. Methods:  ...

: The purpose of this study was to compare photodynamic therapy (PDT), ranibizumab, and ranibizumab with PDT in polypoidal choroidal vasculopathy. : In this retrospective comparative study, 30 eyes of 30 patients with polypoidal choroidal vasculopathy were assigned to 1 of the 3 groups. The patients in Group 1 (n ...

Lean principles have been used at Denver Health Medical Center since 2005 to streamline nonclinical processes. Despite allocation of significant resources, particularly the expense of low molecular weight heparin (LMWH), to prophylaxis of venous thromboembolism (VTE), the incidence of postoperative VTE was significantly worse than national benchmarks. VTE risk factors ...

This study aimed to evaluate treatment effects of intravitreal gas for macular hole with localized retinal detachment (RD) in highly myopic eyes and to examine how the vitreomacular relationship and other factors may influence treatment outcomes. Twenty highly myopic patients with macular holes and localized posterior RD, treated initially with ...

Purpose:  Floaters caused by degenerative or postoperative changes in the vitreous can interfere with all aspects of visual functioning. The aim of this study is to report the longterm outcome of pars plana vitrectomy (PPV) for persistent vitreous opacities. Methods:  In a retrospective, non-randomized, interventional case study we reviewed all ...

Venous thromboembolism (VTE) is a common complication following total hip arthroplasty or total knee arthroplasty and can lead to morbidity and mortality, as well as considerable healthcare costs. However, the incidence of VTE can be greatly minimized with effective thromboprophylaxis administered for the appropriate period of time. While guidelines exist ...

To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). The number of patients with visual loss or visual gain of 3 or more lines of visual acuity (15 ETDRS letters) ...

Triamcinolone acetonide (TA) is one of the first pharmacologic compounds evaluated for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). The most important effects of TA consist in the stabilisation of the blood-retinal barrier and the down-regulation of inflammation. TA also has anti-angiogenic and anti-fibrotic properties. ...

Polypoidal Choroidal Vasculopathy (PCV) is a condition characterized by chronic, multiple, recurrent serous and/or hemorrhagic detachments of the retinal pigment epithelium (RPE) and neurosensory retina. Although it has been described to more often affect Asians and individuals of pigmented races, PCV may also be present in white patients who present ...

Choroidal nevi are generally considered to be stable lesions, and growth of a choroidal nevus is usually believed to be a sign of malignant transformation. We performed this study to determine whether choroidal nevi enlarge over a long period of follow-up without undergoing malignant transformation. Retrospective observational case series. A ...

One powerful method of reconstructing an adult acquired flatfoot deformity is a calcaneocuboid distraction arthrodesis. We performed a retrospective review of a small series of patients who underwent a calcaneocuboid distraction arthrodesis with a femoral head allograft. Sixteen feet (14 patients) were identified with an average follow up of 23 ...

Background:  To determine the effect on macular function of removal of the internal limiting membrane (ILM) during epiretinal membrane surgery. Design:  Prospective, interventional study. Participants:  Twenty-two eyes of 22 patients with idiopathic epiretinal membranes undergoing surgery. Methods:  Histologic analysis of the ILM specimens were classified based on amount of retinal ...

The aim of this study was to compare the effects of face mask and miniscrew combined with Class III traction on Class III malocclusion maxillary deficiency in growing patients. 10 patients were treated with facemask and 10 other patients were treated by means of miniscrew and Class III traction. Pre- ...

The purpose of this study was to describe the single surgery anatomic success rates and visual outcomes of primary macula-on retinal detachment repaired within 24 hours compared with later than 24 hours. This is a retrospective, comparative, interventional, consecutive case series. All eyes underwent primary surgical repair of the macula-on ...

Malocclusion with severe crowding is difficult to treat without extraction. However, in some cases extraction treatment can be compromised by a patient's profile and desire for shorter treatment duration. This article represents a Class II nonextraction treatment approach for a labially displaced canine in a patient with a dished-in profile ...

This study investigated, using cone beam computed tomography (CBCT), the spatial mandibular positioning after rapid maxillary expansion (RME) in Class II Division 1 malocclusion. This prospective study evaluated 17 children (mean initial age 10.36 years old) presenting Class II, Division 1 malocclusion and skeletal maxillary constriction that underwent to RME ...

To investigate the effect of postoperative systemic steroid therapy on the incidence and duration of the subretinal fluid (SRF) and its correlation with the visual outcome after scleral buckle surgery for macula-off rhegmatogenous retinal detachment. Prospective interventional study of sixty patients with macula-off rhegmatogenous retinal detachment who undertook scleral buckle ...

The aim of the study was to analyze the management and outcome in the case of giant peptic ulcer hemorrhage (GPUH). Material and METHODS. We analyzed the data of all 372 cases of 348 patients treated for acute peptic ulcer hemorrhage during 2005-2007. The source and intensity of hemorrhage was ...

Purpose. To describe the clinical response following anti-vascular endothelial growth factor (VEGF) therapy in patients with spontaneous retinal pigment epithelium (RPE) tears secondary to age-related macular degeneration (AMD). Methods. Retrospective chart review of patients with AMD who developed a spontaneous RPE tear and were subsequently treated with anti-VEGF therapy at ...

To report the macular hole closure rate and visual outcomes of patients with residual triamcinolone acetonide in the fovea after macular hole repair. We reviewed the medical records of consecutive patients who underwent macular hole surgery at our institution between 2005 and 2008. Only patients with visible triamcinolone in the ...

Purpose. To present the anatomic and functional results of pars plana vitrectomy performed in severe complicated toxoplasmic retinochoroiditis. Methods. Three patients, 2 women and 1 man aged 57, 22, and 57 years, are presented. The first patient was under immunosuppressive therapy for dermatomyositis and underwent diagnostic/therapeutic vitrectomy for severe toxoplasmic ...

Objective: To identify the outcome of below knee bypass that focuses on the functional status and to investigate whether preoperative functional status can predict these outcomes. Materials and Methods: One hundred and fifty one limbs in one hundred and thirty two patients that underwent below knee bypass between 2004 and ...

The aim of our study was to identify the most important anatomical landmarks in the cephalometric evaluation of Class III patients and to clarify the morphological characteristics of these cases. A group of 10 Class III orthodontic patients was evaluated in this study. The control group consisted of 10 patients ...

: To compare the efficacy of lateral orbital decompression with medial orbital decompression for the treatment of compressive optic neuropathy (CON) caused by thyroid eye disease (TED). : A retrospective review of all patients undergoing orbital decompression for TED-associated CON between 2003 and 2008 was conducted. Clinical outcome measures included ...

Lesions missed by capsule endoscopy (CE) have been reported and this may be partly because of the properties of the capsule. We aimed to compare the ability of Pillcam SB1, SB2, ESO1 and ESO2 to identify the ampulla of Vater (AoV). Patients were divided into four groups: SB1 [single head ...

To investigate the benefit of adding bevacizumab to intravitreal recombinant tissue plasminogen activator (rTPA) and gas as initial therapy in subretinal hemorrhage and choroidal neovascularization because of age-related macular degeneration. Thirty-eight consecutive patients with recent (1-31 days) subretinal hemorrhage who were treated with intravitreal rTPA and gas (26 patients) or ...

Selecting the device size using a sizing balloon could oversize the ostium secundum atrial septal defect (OSASD) with floppy margins and at times may lead to complications. Identifying the firm margins using trans-esophageal echocardiography (TEE) and selecting appropriate-sized device optimizes ASD device closure. This retrospective study was undertaken to document ...

Purpose. To evaluate the safety and effect of combined intravitreal methotrexate and bevacizumab on choroidal neovascularization in age-related macular degeneration (AMD). Methods. Seven eyes of 7 patients (4 female; mean age 65.43±5.96 years) with choroidal neovascularization secondary to AMD were studied. Patients received intravitreal injection of methotrexate and bevacizumab and ...