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Juma James M - - 2014
In Tanzania, routine individual-level testing for HIV drug resistance (HIVDR) using laboratory genotyping and phenotyping is not feasible due to resource constraints. To monitor the prevention or emergence of HIVDR at a population level, WHO developed generic strategies to be adapted by countries, which include a set of early warning ...
Englberger Lars L From the *Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland; †Department of Anesthesiology, Working Group of Perioperative Hemostasis, University of Munich, Munich, Germany; and ‡Department of Anesthesiology and Pain Therapy, University Hospital Berne, Berne, - - 2014
Antifibrinolytics have been used for 2 decades to reduce bleeding in cardiac surgery. MDCO-2010 is a novel, synthetic, serine protease inhibitor. We describe the first experience with this drug in patients. In this phase II, double-blind, placebo-controlled study, 32 patients undergoing isolated primary coronary artery bypass grafting with cardiopulmonary bypass ...
Hayashi Meiso M Department of Cardiovascular Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, - - 2014
Atrial tachyarrhythmias (AT) commonly recur within the first 3 months after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF), and the influence of antiarrhythmic drugs (AADs) on the recurrences has not been fully elucidated. We sought to evaluate the efficacy of a 3-month lower-dose flecainide regime on early and late ...
Incorvaia C C Pulmonary Rehabilitation Unit, Istituti Clinici di Perfezionamento, Presidio Ospedaliero CTO, Milan, Italy - - - 2014
Chronic obstructive pulmonary disease (COPD) causes an impairment of respiratory function, well reflected by the progressive decrease in forced expiratory volume in 1 second (FEV1). The only interventions able to slow down the FEV1 decline are smoking cessation and drug treatment. Pulmonary rehabilitation (PR), is claimed to improve exercise tolerance, ...
Fanelli F F Unit of Vascular and Interventional Radiology Department of Radiological Sciences "Sapienza" University of Rome, Rome, Italy - - - 2014
The aim of the present paper was to make a report of the 12-month clinical outcomes of the DEBELLUM (Drug-Eluting-Balloon-Evaluation-for-Lower-Limb- mUltilevel-treatMent) randomized trial. From September 2010 to March 2011, 50 patients were randomized between drug eluting balloon (DEB, N.=25) and conventional angioplasty balloon (PTA, N.=25). Patients were symptomatic for claudication ...
De Luca Giuseppe G Division of Cardiology, Ospedale "Maggiore della Carità", Eastern Piedmont University, C.so Mazzini, 18, 24100, Novara, Italy, - - 2014
Several concerns have emerged on the higher risk of in-stent thrombosis after drug-eluting stent (DES) implantation, especially in the setting of STEMI patients. Few data have even been reported in high-risk patients, such as those with anterior MI. Therefore this represents the aim of the current study. The literature was ...
Kim Kyungmi K Department of Anaesthesia and Pain Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of - - 2014
The efficacy and side-effects of nefopam were prospectively compared with those of fentanyl for patient-controlled analgesia (PCA) following cardiac surgery. Patients scheduled to undergo cardiac surgery were randomly assigned between three PCA groups (nefopam, fentanyl or nefopam + fentanyl). Pain was assessed at rest and during movement at 12, 24, ...
Barbash Israel M IM MedStar Washington Hospital Center, 110 Irving Street, NW, Suite 4B-1, Washington, DC 20010 USA. - - 2014
This study aimed to assess the long-term safety and clinical effectiveness of the Xience V everolimus-eluting stent (EES) compared to both Taxus paclitaxel-eluting stent (PES) and Cypher sirolimus-eluting stent (SES) in an unselected patient population. There are limited long-term data comparing Xience V EES vs the first-generation Cypher SES. This ...
Romaguera Rafael R Hospital Universitari de Bellvitge, Heart Diseases Institute, Feixa Llarga s/n, Barcelona, 08907, Spain. - - 2014
Some modifications introduced in the design of the new generation of drug-eluting stent (DES) to improve their flexibility may entail a reduction in their longitudinal strength. This study sought to evaluate the longitudinal deformation of DESs by multislice computed tomography (MSCT). This study included DESs that could have been potentially ...
Bhangu Aneel A Department of Colorectal Surgery, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK, - - 2014
Enhanced recovery programs following colorectal resection recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) as part of multimodal analgesia. The present study aimed to assess whether postoperative NSAID use increased the risk of anastomotic leak. A systematic review of published literature was performed for studies comparing anastomotic leak following NSAID ...
Carretero G G Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, - - 2014
Biobadaderm is the Spanish registry of psoriasis patients receiving systemic treatment in clinical practice. To compare the safety of biologics and classic systemic treatment. Prospective cohort of patients receiving biologics and classic systemic therapies between 2008 and 2013 in 12 hospitals are included. We registered demographic data, diagnoses, comorbidities, treatments ...
Bassaw B B Department of Obstetrics and Gynaecology, Mt. Hope Maternity Hospital , Trinidad , West - - 2014
The aim of this randomised prospective study was to investigate the impact of preoperative gonadotrophin-releasing hormone agonist (GnRHa) compared with a control group with myomectomy. A total of 36 women (n = 36, group 1) with fibroids were randomised to receive either 2 monthly doses (n = 18/36, group 1a) ...
Murgier J J Service d'orthopédie-traumatologie, institut de l'appareil locomoteur, hôpital Pierre-Paul-Riquet, 308, avenue de Grande-Bretagne, 31059 Toulouse, France. Electronic address: - - 2014
Cryotherapy is a useful adjunctive analgesic measure in patients with postoperative pain following anterior cruciate ligament (ACL) surgery. Either static permanent compression or dynamic intermittent compression can be added to increase the analgesic effect of cryotherapy. Our objective was to compare the efficacy of these two compression modalities combined with ...
García-García Hector M HM Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The - - 2014
To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. In a multi-centre study, 141 patients ...
Giovanni Giacomo DI GD From the Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, - - 2014
With respect to the first generation Cryoballoon (CB), the second generation (Cryoballoon Advance; Medtronic, USA; CB-A) was designed with technical modifications resulting in a larger and more uniform zone of freezing on the balloons surface aiming at procedural outcome improvement in the setting of atrial fibrillation (AF) ablation. However a ...
Jim Man-Hong MH Cardiac Medical Unit, Grantham Hospital, 125 Wong Chuk Hang Road, Hong Kong, China, - - 2014
The aim of this study was to examine the mid-term angiographic result of T-stenting with small protrusion (TAP) as the bailout strategy for treating coronary bifurcation lesions. From 2009 to 2012, symptomatic patients who had severe coronary bifurcation stenoses were treated with one-stent strategy using drug-eluting stents, with kissing balloon ...
Maeng Michael M Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark. Electronic address: - - 2014
In head-to-head comparisons of coronary drug-eluting stents, the primary endpoint is traditionally assessed after 9-12 months. However, the optimum timepoint for this assessment remains unclear. In this study, we assessed clinical outcomes at up to 5 years' follow-up in patients who received two different types of drug-eluting stents. We undertook ...
Zhang Lei L Department of Cardiology, Shenyang Northern Hospital, Shenyang, - - 2014
The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation remains controversial. The primary aim of our study was to evaluate the impact of optimal DAPT duration on bleeding events between 6 and 12 months after biodegradable polymer-coated DES implantation. The secondary aim is to determine the ...
Costa D D Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra 08193, Barcelona, - - 2014
The objective of this study was to describe and compare the efficacy and duration of topical anaesthesia induced by 2 per cent lidocaine (L), 0.5 per cent bupivacaine (B) and 1 per cent ropivacaine (R) in the dog using 24 clinically healthy beagles with normal ocular examination. Dogs were randomly ...
Yamamoto Hiroyuki H Department of Medicine, Division of Cardiology, Faculty of Medicine, Kinki University, Osaka, - - 2014
This study was carried out to examine the difference in effects between rosuvastatin and pravastatin on neointimal formation after the placement of a drug-eluting stent (DES). Forty patients who underwent placement of a DES in our hospital were prospectively randomized to receive rosuvastatin (n=20) or pravastatin (n=20), and analyzed by ...
Plitt Anna A 1Harvard Medical School, Boston, MA, - - 2014
Vitamin K antagonists (VKAs) remain the standard therapy for anticoagulation in prevention and treatment of venous thromboembolism (VTE) and for the prevention of stroke in atrial fibrillation (AF). Due to numerous limitations of VKAs, target-specific oral anticoagulants have been developed. Edoxaban is a direct activated factor X inhibitor with attractive ...
Letsas Konstantinos P KP Second Department of Cardiology, Laboratory of Cardiac Electrophysiology, Evangelismos General Hospital of Athens, 10676, Athens, - - 2014
Previous studies have underscored the importance of the interpulmonary isthmus in the initiation and maintenance of atrial fibrillation (AF). The efficacy of additional radiofrequency energy delivery in the interpulmonary isthmus following pulmonary vein antral isolation (PVAI) was investigated. A total of 76 patients (49 males, mean age 56.8±10.3) with drug-resistant ...
Abu Daya Hussein H Department of Internal Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States; Division of Gastroenterology and Hepatology, American University of Beirut Medical Center, Beirut, - - 2014
he aim of this study was to determine the effect of antithrombotics on in-hospital mortality and morbidity specifically in patients with peptic ulcer disease (PUB)-related upper gastrointestinal bleeding (UGIB). Patients with PUD-related UGIB, defined as bleeding due to ulcers or erosion in esophagus, stomach and duodenum, were selected from a ...
Hylek Elaine M EM Boston University Medical Center, Boston, MA. Electronic address: - - 2014
We sought to characterize major bleeding based on the components of the major bleeding definition, explore major bleeding by location, define 30-day mortality after a major bleeding event, and identify factors associated with major bleeding. Apixaban was shown to reduce the risk of major hemorrhage among individuals with atrial fibrillation ...
Fanelli F F Vascular and Interventional Radiology Unit, Department of Radiological Sciences,"Sapienza" University of Rome, Rome, Italy - - - 2014
Aim: Report 12month clinical outcomes of DEBELLUM (DrugElutingBalloonEvaluationforLowerLimbmUltileveltreatMent) randomized trial. Methods: From September 2010 to March 2011, 50 patients were randomized between drug eluting balloon (DEB-N=25) and conventional angioplasty balloon (PTA-N=25). Patients were symptomatic for claudication and critical limb ischemia, with denovo stenosis or occlusion in the femoropopliteal (SFA) and ...
de la Torre Hernandez Jose M JM Unidad de Cardiología Intervencionista, Servicio de Cardiología, Hospital Marques de Valdecilla, Santander, Spain. Electronic address: - - 2014
This study sought to investigate the clinical impact of the use of intravascular ultrasound (IVUS) during revascularization of patients with left main coronary artery (LM) disease with drug-eluting stents (DES). Whether the use of IVUS during the procedure adds a clinical benefit remains unclear. There is only 1 previous observational ...
Filingeri V V Department of Experimental Medicine and Surgery, University "Tor Vergata", Rome, Italy. v.filingeri@tiscali.it - - 2014
Control of postoperative symptoms is of paramount importance in proctologic surgery. Phlebotropic activity, protective effect on the capillaries and anti-inflammatory properties of the flavonoids have been reported in several studies. They have been used to treat a variety of conditions including chronic venous insufficiency, lymphedema and hemorrhoids. Numerous trials, assessing the ...
Burgos-Vargas Ruben R PRINTO, Genoa, - - 2014
Enthesitis related arthritis (ERA) is a subcategory of juvenile idiopathic arthritis (JIA) which primarily affects peripheral joints and entheses but also can involve the sacroiliac joints and spine. It causes long-term effects on both physical and quality aspects of a child's life (). Adalimumab (ADA) has been previously demonstrated to ...
Martín-Carbonero L L Infectious Disease Department, Hospital Carlos III, Madrid, - - 2014
Background: Drug intolerance is one of the main reasons for switching antiret-roviral therapy in HIV-infected patients. Etravirine (ETR) has demonstrated good tolerability in clinical trials and may be an option for patients who switch therapy due to adverse events. Methods: We retrospectively reviewed all patients who had switched to an ...
Lee Mi Hyeon MH Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, - - 2014
Remifentanil is a short-acting drug with a rapid onset that is useful in general anesthesia. Recently, however, it has been suggested that the use of opioids during surgery may cause opioid-induced hyperalgesia (OIH). Researchers have recently reported that esmolol, an ultra-short-acing β1 receptor antagonist, reduces the postoperative requirement for morphine ...
Ad Niv N Cardiac Surgery Research, Inova Heart and Vascular Institute, Falls Church, VA, - - 2014
Reporting methods for surgical ablation (SA) of atrial fibrillation (AF) were standardized by the Heart Rhythm Society Guidelines, stating that results should be reported only for the first 2 years following SA. The purpose of this study was to assess the outcome of SA over 5 years and determine predictors ...
Xu Bo B Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, - - 2014
Aims: The SYNTAX score has been proposed as a valuable tool to characterise coronary anatomy prospectively based on its complexity. This study evaluated the prognostic value on adverse outcomes of the residual SYNTAX score (rSS) in patients with complex lesions treated with an everolimus-eluting stent (EES). Methods and results: One ...
Meissner Brian B Bristol-Myers Squibb , Missoula, MT , - - 2014
Abstract Objectives: This study examined total healthcare costs and rates of patients with rheumatoid arthritis (RA) who switch biologic disease-modifying anti-rheumatic drug (bDMARD) therapy in a real world setting. Methods: A retrospective longitudinal analysis was conducted in patients with RA using IMS PharMetrics Plus database from 1/1/2004 to 3/31/2010. The ...
Targownik Laura E LE Section of Gastroenterology, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, - - 2014
Corticosteroids are widely used in the management of inflammatory bowel disease (IBD) and are associated with significant side effects. The real world effectiveness of newer drug therapies at reducing corticosteroid use is yet to be reported. The overall burden of corticosteroid use is poorly characterized. We used a population-based IBD ...
Wang Yuqing Y Cardiovascular Disease Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, - - 2014
Degradable polymer drug-eluting stents (DP-DES) represent a promising strategy to improve the delayed healing and hypersensitive reaction in the vessel. However, the efficacy and safety of DP-DES vs. permanent polymer drug-eluting stents (PP-DES) are less well defined. The aim of this meta-analysis was to compare the total, short (<30days), mid ...
Ejima Koichiro K Department of Cardiology, Tokyo Women's Medical - - 2014
Background: Both the left atrial volume index (LAVI) and estimated total atrial conduction time measured using tissue Doppler imaging of the atria (PA-TDI duration) are echocardiographic parameters reflecting atrial remodeling. We investigated their prognostic value for atrial tachyarrhythmia (AF/AT) recurrence after radiofrequency catheter ablation (RFCA) of paroxysmal atrial fibrillation (PAF). Methods ...
Morillo Carlos A CA McMaster University, Population Health Research Institute, Hamilton Health Sciences, Hamilton, - - 2014
Atrial fibrillation (AF) is the most common rhythm disorder seen in clinical practice. Antiarrhythmic drugs are effective for reduction of recurrence in patients with symptomatic paroxysmal AF. Radiofrequency ablation is an accepted therapy in patients for whom antiarrhythmic drugs have failed; however, its role as a first-line therapy needs further ...
Sherwood Matthew W MW Duke University Medical Center, Duke Clinical Research Institute, Durham, - - 2014
During long-term anticoagulation in atrial fibrillation, temporary interruptions(TI) of therapy are common, but the relationship between patient outcomes and TI has not been well studied. We aimed to determine reasons for TI, the characteristics of patients undergoing TI, and the relationship between anticoagulant and outcomes among patients with TI. In ...
Batirel A A Infectious Diseases and Clinical Microbiology, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Semsi Denizer Cd. E-5 Karayolu Cevizli Mevkii, 34890, Kartal, Istanbul, Turkey, - - 2014
The purpose of this investigation was to compare the efficacy of colistin-based therapies in extremely drug-resistant Acinetobacter spp. bloodstream infections (XDR-ABSI). A retrospective study was conducted in 27 tertiary-care centers from January 2009 to August 2012. The primary end-point was 14-day survival, and the secondary end-points were clinical and microbiological ...
Niu Xiaowei X Lanzhou University. - - 2014
Whether drug-eluting stents with biodegradable polymers (BP-DES) improve safety, especially with respect to stent thrombosis (ST) compared with permanent polymers DES (PP-DES), remains uncertainty. We aimed to compare the short- and long-term outcomes and the ST risk in patients treated with BP-DES versus PP-DES. : METHODS: We searched Medline, Embase, ...
Holmaas Gunhild - - 2014
BACKGROUNDDiagnosis of rare adverse effects of drugs is particularly difficult in the presence of multiple organ failure. We present a patient who developed severe adverse effects from linezolid after 23 days' treatment with the recommended dose.CASE PRESENTATIONA male in his seventies with cardiac disease and diabetic nephropathy was admitted to ...
Calvo-Río Vanesa V Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain. - - 2014
Hypersensitivity vasculitis (HV) and Henoch-Schönlein purpura (HSP) are the most common entities included within the category of cutaneous vasculitis (CV). Palpable purpura and histological changes characterised by the presence of leukocytoclastic vasculitis are common in both conditions. Therefore, considerable overlap between them is often seen. It is especially true when ...
Patanè Domenico D 1 Department of Diagnostic and Interventional Radiology, Azienda Ospedaliera per l'Emergenza "Cannizzaro", Catania - - - 2014
<sec id="st1"><title>ABSTRACT</title> <bold><italic>Purpose:</italic></bold> The purpose of this article is to report our experience with drug-eluting balloons for the treatment of juxta-anastomotic stenoses of failing radiocephalic hemodialytic arteriovenous shunt and to evaluate the primary and secondary patency (PP and SP). <bold><italic>Methods:</italic></bold> After approval by the local hospital's Ethical and Scientific Review ...
Gagne Joshua J JJ Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA, - - 2014
Methods for near-real-time monitoring of new drugs in electronic healthcare data are needed. In a novel application, we prospectively monitored ischemic, bleeding, and mortality outcomes among patients initiating prasugrel versus clopidogrel in routine care during the first 2 years following the approval of prasugrel. Using the HealthCore Integrated Research Database, we ...
Nakase Taizen T Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan. Electronic address: - - 2014
Our objective was to investigate the effect of cilostazol in acute therapy for small vessel stroke patients. The neurologic deficits in some patients of small vessel brain infarction will progress even if a patient takes immediate medical treatments including aspirin or other antiplatelet drugs. In Japan, cilostazol, presenting not only ...
Tian Feng F Department of Cardiology, Chinese PLA General Hospital, Beijing, PR - - 2014
Objective: This study aims to assess the characteristics of neointimal hyperplasia after drug-eluting stent (DES) implantation in patients with diabetes mellitus (DM) by optical coherence tomography (OCT). Methods: OCT was performed in 109 patients (45 with DM and 64 without DM) 1 year after DES implantation. Neointimal coverage and thickness ...
Alvarez-Sabín José J Department of Neurology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Background: The mean follow-up in the clinical trials of antiplatelet drugs in the secondary prevention of ischemic atherothrombotic stroke ranges from 1 to 5.5 years. Thus, the safety and efficacy of these drugs in the very long term is not totally documented. We have assessed the safety and effectiveness of ...
Liistro Francesco F 1 Cardiovascular Department - - 2014
Purpose : To test the ability of a drug-eluting balloon (DEB) to reduce recurrent in-stent restenosis (ISR) in diabetic patients with femoropopliteal stents. Methods : A prospective all-comers study [Drug-Eluting Balloon in Peripheral Intervention for In-Stent Restenosis (DEBATE-ISR); ClinicalTrials.gov identifier NCT01558531] of symptomatic diabetic patients with femoropopliteal ISR undergoing treatment ...
Chilipko Allison A AA MedStar Union Memorial Hospital, Baltimore, - - 2014
Objective: The purpose of this study was to evaluate warfarin management by pharmacists compared with physicians through an inpatient anticoagulation management service (AMS).Design: Retrospective cohort study.Setting: Community teaching hospital.Patients, Participants: Patients were randomly selected from the Inpatient AMS from January 1, 2009 to January 1, 2011. Patients were included if ...
Hijazi Omar M OM Department of Cardiac Sciences, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Kingdom of Saudi Arabia. Fax. +966 (11) 8011111 Ext. 16560. E-mail: - - 2014
To compare sedation outcomes for chloral hydrate (CH) and midazolam (MD) as sedative agents for diagnostic procedures in children. A prospective, randomized, double-blinded study conducted between July 2005 and October 2006, at the Pediatric Day Care Unit (DCU), King Abdulaziz Medical City, Riyadh, Saudi Arabia. After meeting the inclusion criteria ...
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