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Results 201 - 250 of 1510
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Hanon Olivier O Service de gérontologie, Hôpital Broca, Paris, - - 2013
Atrial fibrillation treatment relies on anticoagulation therapy that reduces the risk of stroke. Vitamin K antagonists (VKA) were the only oral anticoagulant drugs for more than 50 years, but they are difficult to manage especially in the elderly. In France, VKA are the main cause of iatrogenic hospitalizations with about ...
Lee Sang-Hoon SH Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, College of Dentistry, Yonsei University, Seoul, - - 2013
Alloplastic total replacement of the temporomandibular joint (TMJ) was developed in recent decades. In some conditions, previous studies suggested the rationale behind alloplastic TMJ replacement rather than reconstruction with autogenous grafts. Currently, three prosthetic products are available and approved by the US Food and Drug Administration. Among these products, customized ...
Matti Bassam Francis BF Baghdad Teaching Hospital, Clinical Hematology Department, Baghdad, - - 2013
Imatinib mesylate, a tyrosine kinase inhibitor, is presently the drug of choice for chronic myeloid leukemia (CML). During therapy, a few patients may develop hematological and non-hematological adverse effects. The aim of this study was to evaluate the safety of imatinib therapy in patients with CML. Between December 2007 and ...
Rachidi Saleh S Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, - - 2013
Venous thromboembolism is a common cause of morbidity and mortality among patients undergoing elective orthopedic surgery. Due to the high incidence of venous thromboembolism in this setting, perioperative anticoagulation is the recommended approach for thromboprophylaxis. Low molecular weight heparin (LMWH), fondaparinux and warfarin are the agents commonly used for thromboprophylaxis. ...
Tada Tomohisa T Deutsches Herzzentrum, Technische Universität, Munich, - - 2013
This study sought to compare the risk of stent thrombosis among patients treated with bare-metal stents (BMS), first-generation drug-eluting stents (G1-DES), and second-generation drug-eluting stents (G2-DES) for a period of 3 years. In patients undergoing coronary stenting, there is a scarcity of long-term follow-up data on cohorts large enough to ...
Waksman Ron - - 2013
THE DRUG-ELUTING ABSORBABLE METAL SCAFFOLD HAS DEMONSTRATED FEASIBILITY, SAFETY, AND PROMISING CLINICAL AND ANGIOGRAPHIC OUTCOMES AT 12 MONTHS IN HUMAN CORONARY ARTERIES. THIS STUDY AIMED TO EVALUATE THE DEGRADATION RATE AND LONG-TERM VASCULAR RESPONSES TO DRUG-ELUTING ABSORBABLE METAL SCAFFOLD.METHODS AND RESULTS: BIOSOLVE-I WAS A MULTICENTER, SINGLE-ARM, FIRST-IN-MAN TRIAL ASSESSING THE ...
Cañas-Ventura Alex A Alex Cañas-Ventura, Lucia Márquez, Xavier Bessa, Josep Maria Dedeu, Marc Puigvehí, Sílvia Delgado-Aros, Ines Ana Ibáñez, Agustin Seoane, Luis Barranco, Felipe Bory, Montserrat Andreu, Department of Gastroenterology, Hospital del Mar Research Institute, Pompeu Fabra University, 08003 Barcelona, - - 2013
To investigate the clinical impact of capsule endoscopy (CE) after an obscure gastrointestinal bleeding (OGIB) episode, focusing on diagnostic work-up, follow-up and predictive factors of rebleeding. Patients who were referred to Hospital del Mar (Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic ...
Berling I - - 2013
Objective. There is limited information on mirtazapine overdose, but cases of severe effects (seizures, serotonin toxicity and coma) have been reported. We aimed to investigate the clinical effects and complications of mirtazapine overdose. Methods. This was an observational case series of mirtazapine overdoses (> 120 mg) identified from admissions to ...
Otake Hironao - - 2013
Abstract Conclusion: The results indicate that oral administration of azithromycin (AZM) is equivalent to intravenous administration of cefazolin (CEZ) for preventing surgical site infection (SSI) in patients undergoing tonsillectomy, and should be used as cost-effective antimicrobial prophylaxis. Objective: Staphylococcus aureus, Streptococcus spp., and pharyngeal anaerobes have been described as major ...
Gray William A - - 2013
BACKGROUND Carotid artery stenting (CAS) was introduced in the US approximately a decade ago as a novel treatment of severe carotid stenosis. Voluminous and high quality prospective data permit analysis of longitudinal trends in CAS outcomes. METHODS Outcomes from all prospective trials with Food and Drug Administration (FDA) oversight from ...
de Belder Adam - - 2013
To determine whether drug-eluting stents (des) are superior to bare metal stents (bms) in octogenarian patients with angina. Patients aged ≥80 years frequently have complex coronary disease warranting des, but have a higher bleeding risk from prolonged dual antiplatelet treatment. This multicenter, randomized trial was conducted in 20 centers in ...
Kurasawa Takahiko - - 2013
Objectives. We examined whether the addition of another conventional disease-modifying anti-rheumatic drugs (DMARDs) to methotrexate (MTX) upon infliximab (IFX) discontinuation in well-controlled rheumatoid arthritis (RA) patients could suppress subsequent disease flare. Methods. RA patients maintaining DAS28-CRP (Disease Activity Score of 28 joints with C-reactive protein) scores < 2.6 for ≥ ...
Wang Sharon M - - 2013
Gout is a chronic rheumatic disease that can have serious sequelae, including persistent pain, nerve compression, joint destruction and deformities if left untreated. Febuxostat, initially introduced in the United States in 2009, was the first new treatment option for gout in over 40 years. With the introduction of a new ...
Norton Linda - - 2013
Background Intravenous amiodarone is an important treatment for arrhythmias, but peripheral infusion is associated with direct irritation of vessel walls and phlebitis rates of 8% to 55%. Objectives To determine the incidence and factors contributing to the development of amiodarone-induced phlebitis in the coronary care unit in an academic medical ...
Foroughipour Mohsen - - 2013
Migraine is one of the most common types of headache, with significant socioeconomic effects. Prophylactic drugs are used to prevent migraine headaches but are unpromising. To assess the effects of adding acupuncture to conventional migraine prophylaxis. One hundred patients with migraine (41 male, 59 female), in whom prophylactic drugs had ...
De Maat Gijs E GE From the *Department of Cardio-Thoracic Surgery, and †Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; ‡Cardiac Surgery Unit, San Raffaele Scientific Institute, Milan, Italy; §Department of Cardiology, Medisch Spectrum Twente, Enschede, The Netherlands; and ∥Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The - - 2013
Minimally invasive surgical pulmonary vein isolation (SMI-PVI) is an emerging therapy for the treatment of symptomatic drug-refractory atrial fibrillation (AF). Nevertheless, the midterm and long-term results of SMI-PVI remain unknown. The aim of this retrospective multicenter study was to report on midterm efficacy and safety of SMI-PVI. The study design ...
Goyal B K BK Interventional Cardiologist, Bombay Hospital of Medical Sciences, Mumbai 400020, India; Director, Medical Education and Research, Bombay Hospital, - - 2013
New generation DES are effectively used in all spectrum of coronary artery diseases (CAD) and are replacing earlier DES and BMS. Biolimus A9™-eluting stent is a new generation DES containing the anti-proliferative drug biolimus A9™ incorporating a biodegradable abluminal coating that leaves a polymer-free stent after drug release enhancing strut ...
- - 2013
About 80% of strokes are ischaemic. Approximately 12% of patients die within 3 months following stroke, and another 20% are institutionalised or become highly dependent. In early 2013, what is the harm-benefit balance of antithrombotic treatments used in the acute phase of ischaemic stroke? To answer this question, we reviewed ...
Cai Yuankun - - 2013
To study the pharmacokinetics of carbon nanoparticle-paclitaxel suspension (CNPS) in intraperitoneal chemotherapy. Thirty-three Wistar rats were randomly assigned to an experimental group (A) and a control group (B), to which intraperitoneal injections of CNPS and paclitaxel were administered, respectively. At time points ranging from 10 min to 7 days, we ...
Raveglia Federico - - 2013
Pain control after thoracotomy prevents postsurgical complications and improves respiratory function. The gold standard for post-thoracotomy analgesia is the epidural catheter. The aim of this study was to compare it with a new technique that involves placement of a catheter in the paravertebral space at the end of surgery under ...
Ahuja Rajeev B - - 2013
There is not much level 1 evidence based literature to guide management of hypertrophic scars and keloids despite an array of therapeutic modalities at disposal. Intralesional (i/l) triamcinolone injections have remained a gold standard in non surgical management. Sporadic reports on use of i/l verapamil suggest its efficacy. Since verapamil ...
Chiang Min-Hsien MH Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2013
The best anesthesia methods for analgesia and sedation during gastrointestinal endoscopy are still debated. The aim of this study was to compare the recovery time, clinical presentations, and satisfaction between target-controlled infusion (TCI) and manually controlled infusion (MCI) in same-day bidirectional endoscopy (esophagogastroduodenoscopy followed by colonoscopy). A total of 220 ...
Gasparini Maurizio M Electrophysiology and Pacing Unit, Humanitas Research Hospital, Rozzano, Italy. Electronic address: - - 2013
The purpose of this study is to determine whether, in patients with atrial fibrillation (AF) undergoing cardiac resynchronization therapy (CRT), atrioventricular junction ablation (AVJA) is associated with a better outcome than treatment with rate-slowing drugs. Different trials have demonstrated that CRT is effective in treating heart failure (HF) patients who ...
Demirel Ismail - - 2013
To evaluate and compare analgesic efficacy, drug consumption and patient satisfaction with the i.v. patient-controlled and continuous infusion modes of administration of tramadol. A total of 40 pregnant women in American Society of Anesthesiologists physical status classification system risk classes I-II scheduled for cesarean section were randomized into two groups ...
Hirayama Atsushi - - 2013
Background: A prospective, 3-year comparative observational study compared the risk of cardiovascular events in patients with osteoarthritis or rheumatoid arthritis prescribed celecoxib or a nonsteroidal antiinflammatory drug (NSAID). Methods and Results: Patients prescribed celecoxib (n=5,470) or NSAIDs (n=5,059) between November 1, 2007, and July 31, 2008 in 1,084 hospitals and clinics in ...
Wijemanne Subhashie - - 2013
Haloperidol and pimozide are the only drugs currently approved by the U.S. Food and Drug Administration for treatment of Tourette syndrome (TS), but their potential side effects, which include tardive dyskinesia (TD), limit their use. We performed a retrospective chart review of patients with TS treated with fluphenazine over a ...
Zhong Li - - 2013
It is unknown whether radiofrequency ablation (RFA) or antiarrhythmic therapy is superior when treating patients with symptomatic premature ventricular contractions. This single center retrospective study is designed to determine the relative efficacy of RFA and antiarrhythmic drugs (AADs) on decreasing PVC burden and improving left ventricular (LV) systolic function. Patients ...
Zhou Bo Rong - - 2013
Stroke victims often exhibit clopidogrel resistance (CR). This prospective study was undertaken to observe changes that influence CR in the secondary prevention of cerebral infarction (CI). The study included 56 cases at high risk of stroke (HRS), 147 cases of CI and 68 control subjects. The CI and HRS groups ...
Morgan Christopher Ll CL Pharma Research Centre, Cardiff MediCentre, School of Medicine, Institute of Primary Care and Public Health, Cardiff University, Cardiff CF14 4UJ, UK. - - 2014
The objective of this study was to examine the long-term safety of etanercept (ETN) in comparison with conventional DMARDs in a large observational cohort of RA patients in the UK. Data were made available from the British Society of Rheumatology Biologics Register for a cohort of patients with RA treated ...
Rajasekhar D - - 2013
This INDOLIMUS Registry sought to evaluate the safety and efficacy of the biodegradable polymer coated Indolimus(®) sirolimus-eluting coronary stent for the treatment of coronary artery disease across a wide range of patients treated in routine clinical practice, including those with high-risk characteristics and complex lesions. First-generation drug-eluting stents utilize non-biodegradable ...
Jafarzadeh Fatemeh - - 2013
Paraplegia is a rare but devastating complication, which may follow thoracoabdominal aortic surgery. Many adjuncts have been developed to reduce this risk including cerebrospinal fluid (CSF) drainage. Acetazolamide (carbonic anhydrase inhibitor) is a drug used to counteract mountain sickness and one of its effects is to reduce CSF production. Here, ...
Berruezo Antonio - - 2013
Perimitral flutter (PMF) is a common form of left atrial tachycardia (LAT) after atrial fibrillation (AF) ablation. The mitral isthmus (MI) is the standard ablation target. However, in some cases bidirectional block cannot be achieved. We describe the first experience using a transthoracic epicardial (TTE) approach to treat recurrent PMF ...
Loh Joshua P - - 2013
Drug-eluting stents (DES) are routinely used in complex patients, but the impact of 1st- versus 2nd-generation DES on clinical outcomes has not been well described. This study aimed to assess the efficacy and safety of 2nd-generation (everolimus-eluting) DES compared to 1st-generation (sirolimus- and paclitaxel-eluting) DES in a selected, higher-risk population ...
Pumberger Matthias - - 2013
A feared complication of spinal or epidural anesthesia is the development of epidural or spinal hematoma with subsequent neural element compression. Most available data are derived from the obstetric literature. Little is known about the frequency of hematoma occurrence among patients undergoing orthopedic joint arthroplasty, who are usually elderly and ...
Young Af - - 2013
Background: In trauma and orthopaedic surgery high flow oxygen can save lives by preventing severe hypoxaemia. Conversely, excessive oxygen can cause harm, and inadequate monitoring of its use has been reported in both pre-hospital and hospital audits. In 2008 the British Thoracic Society published guidelines on the use of emergency ...
Oliveira Flavio Roberto Azevedo de - - 2013
Small vessels represent a risk factor for restenosis in percutaneous coronary angioplasty (PCA). The Sparrow® self-expanding drug-eluting stent, which has a lower profile than the current systems, has never been tested in this scenario. To evaluate the late effectiveness of the Sparrow® drug-eluting stent, regarding in-stent late lumen loss (LLL). ...
Alipour Mohammad - - 2013
Some studies have proved that Tranexamic acid infusion is associated with a decrease in blood loss during and after surgery. Due to the availability of an oral form of the drug, the rapid and complete absorption of it and ease of administration without need for specific instruments, we evaluated the ...
Al-Haideri Yahya A A - - 2013
To evaluate the efficacy of local anesthesia using tramadol hydrochloride (HCl) with versus without adrenaline in the extraction of upper molar teeth. This was a double-blinded study that included 100 patients who required extraction of 1 upper molar by the conventional method and were allocated randomly into 1 of 2 ...
Li Mu-Xing - - 2013
Portal vein thrombosis (PVT) is a potential lethal complication and may have negative influence on the prognosis after splenectomy in patients with liver cirrhosis. Prevention and timely detection of PVT are quite significant. There is a lack of knowledge about the clinical features and risk factors of PVT. Our study ...
Herrador Juan A - - 2013
The origin of the side branch (SB) is the most common site for restenosis in coronary bifurcations. The end-point is to compare the results of SB dilation with drug-eluting balloon (DEB group) versus conventional balloon (BAL group) in bifurcations treated with provisional T stenting. Each group included 50 patients. In ...
Yue De-Bo - - 2013
Multimodal cocktail periarticular injection (MCPI) with a large volume of low concentration local anesthetics, adrenaline, and anti-inflammatory agents such as non-steroidal anti-inflammatory drug or steroids have shown good pain control and improvement in range of motion after surgery. This study compares the efficacy of pain control after total knee arthroplasty, ...
Faiz Seyed Hamid Reza - - 2013
Regional anesthesia is known to significantly impair thermoregulation and predispose patients to hypothermia. We hypothesized that the addition of an intrathecal injection of magnesium sulfate (MgSO4) to bupivacaine would improve perioperative shivering in female patients undergoing elective caesarean section. In a block-randomized, double-blinded, controlled trial 72 patients scheduled for elective ...
Goswami Upasana U Department of Anesthesiology, Deen Dayal Upadhyay Hospital, New Delhi, - - 2013
Postpartum hemorrhage (PPH) and anemia thereafter can be a life threatening condition in parturients undergoing lower segment cesarean section (LSCS), especially when anemia is present. The objective of this study was to assess two doses of Tranexamic acid (TXA) in reducing intra operative blood loss and incidence of PPH, in ...
Aghokeng Avelin F - - 2013
Background. The limited access to virological monitoring in developing countries is a major weakness of the current antiretroviral treatment (ART) strategy in these settings. We conducted a large cross-sectional study in Burkina-Faso, Cameroon, Cote d'Ivoire, Senegal, Togo, Thailand and Vietnam to assess virological failure (VF) and drug resistance mutations (DRMs) after ...
Yamaguchi Takanori - - 2013
To examine the impact of left atrial (LA) low-voltage zones (LVZs) on atrial fibrillation (AF) recurrence after pulmonary vein antrum isolation (PVAI) without LA substrate modification.METHODS AND RESULTS: Seventy-six patients with AF (paroxysmal/persistent 65/11) were prospectively enroled. Left atrial voltage maps were constructed during sinus rhythm using NavX to identify ...
Valgimigli Marco - - 2013
The use of drug-eluting stent (DES) instead of bare-metal stent (BMS) in patients at high stent thrombosis or bleeding risk as well as in those at low restenosis risk (ie, uncertain DES candidates) remains a matter of debate. Zotarolimus-Eluting Endeavor Sprint stent (E-ZES) (Santa Rosa, CA) is a hydrophilic polymer-based ...
Maldonado-Ávila Miguel - - 2013
To compare the efficacy and safety of tamsulosin and alfuzosin in patients with acute urinary retention (AUR) secondary to benign prostatic hyperplasia (BPH). Ninety men with AUR due to BPH underwent urinary catheterization and were randomly assigned to treatment groups with tamsulosin 0.4 mg (37 patients), alfuzosin 10 mg (34 patients), and ...
Kerner Arthur - - 2013
The current revascularization treatment recommendation is different according to lesion location and a higher recommendation is given to surgery for proximal LAD (pLAD) lesions over PCI. This is based on previous studies and expert opinion. We aimed to investigate whether indeed there is a difference in outcome with respect to ...
Solari Diana - - 2013
The prevalence and outcome of carotid sinus syndrome (CSS) reported in the literature vary owing to differences in indications and methods of carotid sinus massage (CSM).METHODS AND RESULTS: We performed CSM on all patients aged 40 years and above with unexplained syncope after the initial evaluation. Carotid sinus massage was ...
Ormiston John J Mercy Angiography Unit, Auckland, New Zealand; Auckland City Hospital, Auckland, New Zealand. Electronic address: - - 2013
This first-in-human multicenter study sought to examine prospectively the safety and efficacy of a new, cobalt chromium thin-strut, coronary absorbable polymer-coated, sirolimus-eluting stent. Bioabsorbable polymers on drug-eluting stents may lower the long-term risks of inflammation, delayed healing, and adverse events. We enrolled patients with symptomatic coronary artery disease with stable ...
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