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Costa D D Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra 08193, Barcelona, - - 2014
The objective of this study was to describe and compare the efficacy and duration of topical anaesthesia induced by 2 per cent lidocaine (L), 0.5 per cent bupivacaine (B) and 1 per cent ropivacaine (R) in the dog using 24 clinically healthy beagles with normal ocular examination. Dogs were randomly ...
Yamamoto Hiroyuki H Department of Medicine, Division of Cardiology, Faculty of Medicine, Kinki University, Osaka, - - 2014
This study was carried out to examine the difference in effects between rosuvastatin and pravastatin on neointimal formation after the placement of a drug-eluting stent (DES). Forty patients who underwent placement of a DES in our hospital were prospectively randomized to receive rosuvastatin (n=20) or pravastatin (n=20), and analyzed by ...
Plitt Anna A 1Harvard Medical School, Boston, MA, - - 2014
Vitamin K antagonists (VKAs) remain the standard therapy for anticoagulation in prevention and treatment of venous thromboembolism (VTE) and for the prevention of stroke in atrial fibrillation (AF). Due to numerous limitations of VKAs, target-specific oral anticoagulants have been developed. Edoxaban is a direct activated factor X inhibitor with attractive ...
Letsas Konstantinos P KP Second Department of Cardiology, Laboratory of Cardiac Electrophysiology, Evangelismos General Hospital of Athens, 10676, Athens, - - 2014
Previous studies have underscored the importance of the interpulmonary isthmus in the initiation and maintenance of atrial fibrillation (AF). The efficacy of additional radiofrequency energy delivery in the interpulmonary isthmus following pulmonary vein antral isolation (PVAI) was investigated. A total of 76 patients (49 males, mean age 56.8±10.3) with drug-resistant ...
Abu Daya Hussein H Department of Internal Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States; Division of Gastroenterology and Hepatology, American University of Beirut Medical Center, Beirut, - - 2014
he aim of this study was to determine the effect of antithrombotics on in-hospital mortality and morbidity specifically in patients with peptic ulcer disease (PUB)-related upper gastrointestinal bleeding (UGIB). Patients with PUD-related UGIB, defined as bleeding due to ulcers or erosion in esophagus, stomach and duodenum, were selected from a ...
Hylek Elaine M EM Boston University Medical Center, Boston, MA. Electronic address: - - 2014
We sought to characterize major bleeding based on the components of the major bleeding definition, explore major bleeding by location, define 30-day mortality after a major bleeding event, and identify factors associated with major bleeding. Apixaban was shown to reduce the risk of major hemorrhage among individuals with atrial fibrillation ...
Fanelli F F Vascular and Interventional Radiology Unit, Department of Radiological Sciences,"Sapienza" University of Rome, Rome, Italy - - - 2014
Aim: Report 12month clinical outcomes of DEBELLUM (DrugElutingBalloonEvaluationforLowerLimbmUltileveltreatMent) randomized trial. Methods: From September 2010 to March 2011, 50 patients were randomized between drug eluting balloon (DEB-N=25) and conventional angioplasty balloon (PTA-N=25). Patients were symptomatic for claudication and critical limb ischemia, with denovo stenosis or occlusion in the femoropopliteal (SFA) and ...
de la Torre Hernandez Jose M JM Unidad de Cardiología Intervencionista, Servicio de Cardiología, Hospital Marques de Valdecilla, Santander, Spain. Electronic address: - - 2014
This study sought to investigate the clinical impact of the use of intravascular ultrasound (IVUS) during revascularization of patients with left main coronary artery (LM) disease with drug-eluting stents (DES). Whether the use of IVUS during the procedure adds a clinical benefit remains unclear. There is only 1 previous observational ...
Filingeri V V Department of Experimental Medicine and Surgery, University "Tor Vergata", Rome, Italy. v.filingeri@tiscali.it - - 2014
Control of postoperative symptoms is of paramount importance in proctologic surgery. Phlebotropic activity, protective effect on the capillaries and anti-inflammatory properties of the flavonoids have been reported in several studies. They have been used to treat a variety of conditions including chronic venous insufficiency, lymphedema and hemorrhoids. Numerous trials, assessing the ...
Martín-Carbonero L L Infectious Disease Department, Hospital Carlos III, Madrid, - - 2014
Background: Drug intolerance is one of the main reasons for switching antiret-roviral therapy in HIV-infected patients. Etravirine (ETR) has demonstrated good tolerability in clinical trials and may be an option for patients who switch therapy due to adverse events. Methods: We retrospectively reviewed all patients who had switched to an ...
Lee Mi Hyeon MH Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, - - 2014
Remifentanil is a short-acting drug with a rapid onset that is useful in general anesthesia. Recently, however, it has been suggested that the use of opioids during surgery may cause opioid-induced hyperalgesia (OIH). Researchers have recently reported that esmolol, an ultra-short-acing β1 receptor antagonist, reduces the postoperative requirement for morphine ...
Ad Niv N Cardiac Surgery Research, Inova Heart and Vascular Institute, Falls Church, VA, - - 2014
Reporting methods for surgical ablation (SA) of atrial fibrillation (AF) were standardized by the Heart Rhythm Society Guidelines, stating that results should be reported only for the first 2 years following SA. The purpose of this study was to assess the outcome of SA over 5 years and determine predictors ...
Xu Bo B Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, - - 2014
Aims: The SYNTAX score has been proposed as a valuable tool to characterise coronary anatomy prospectively based on its complexity. This study evaluated the prognostic value on adverse outcomes of the residual SYNTAX score (rSS) in patients with complex lesions treated with an everolimus-eluting stent (EES). Methods and results: One ...
Meissner Brian B Bristol-Myers Squibb , Missoula, MT , - - 2014
Abstract Objectives: This study examined total healthcare costs and rates of patients with rheumatoid arthritis (RA) who switch biologic disease-modifying anti-rheumatic drug (bDMARD) therapy in a real world setting. Methods: A retrospective longitudinal analysis was conducted in patients with RA using IMS PharMetrics Plus database from 1/1/2004 to 3/31/2010. The ...
Targownik Laura E LE Section of Gastroenterology, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, - - 2014
Corticosteroids are widely used in the management of inflammatory bowel disease (IBD) and are associated with significant side effects. The real world effectiveness of newer drug therapies at reducing corticosteroid use is yet to be reported. The overall burden of corticosteroid use is poorly characterized. We used a population-based IBD ...
Wang Yuqing Y Cardiovascular Disease Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, - - 2014
Degradable polymer drug-eluting stents (DP-DES) represent a promising strategy to improve the delayed healing and hypersensitive reaction in the vessel. However, the efficacy and safety of DP-DES vs. permanent polymer drug-eluting stents (PP-DES) are less well defined. The aim of this meta-analysis was to compare the total, short (<30days), mid ...
Ejima Koichiro K Department of Cardiology, Tokyo Women's Medical - - 2014
Background: Both the left atrial volume index (LAVI) and estimated total atrial conduction time measured using tissue Doppler imaging of the atria (PA-TDI duration) are echocardiographic parameters reflecting atrial remodeling. We investigated their prognostic value for atrial tachyarrhythmia (AF/AT) recurrence after radiofrequency catheter ablation (RFCA) of paroxysmal atrial fibrillation (PAF). Methods ...
Sherwood Matthew W MW Duke University Medical Center, Duke Clinical Research Institute, Durham, - - 2014
During long-term anticoagulation in atrial fibrillation, temporary interruptions(TI) of therapy are common, but the relationship between patient outcomes and TI has not been well studied. We aimed to determine reasons for TI, the characteristics of patients undergoing TI, and the relationship between anticoagulant and outcomes among patients with TI. In ...
Morillo Carlos A CA McMaster University, Population Health Research Institute, Hamilton Health Sciences, Hamilton, - - 2014
Atrial fibrillation (AF) is the most common rhythm disorder seen in clinical practice. Antiarrhythmic drugs are effective for reduction of recurrence in patients with symptomatic paroxysmal AF. Radiofrequency ablation is an accepted therapy in patients for whom antiarrhythmic drugs have failed; however, its role as a first-line therapy needs further ...
Batirel A A Infectious Diseases and Clinical Microbiology, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Semsi Denizer Cd. E-5 Karayolu Cevizli Mevkii, 34890, Kartal, Istanbul, Turkey, - - 2014
The purpose of this investigation was to compare the efficacy of colistin-based therapies in extremely drug-resistant Acinetobacter spp. bloodstream infections (XDR-ABSI). A retrospective study was conducted in 27 tertiary-care centers from January 2009 to August 2012. The primary end-point was 14-day survival, and the secondary end-points were clinical and microbiological ...
Niu Xiaowei X Lanzhou University. - - 2014
Whether drug-eluting stents with biodegradable polymers (BP-DES) improve safety, especially with respect to stent thrombosis (ST) compared with permanent polymers DES (PP-DES), remains uncertainty. We aimed to compare the short- and long-term outcomes and the ST risk in patients treated with BP-DES versus PP-DES. : METHODS: We searched Medline, Embase, ...
Holmaas Gunhild - - 2014
BACKGROUNDDiagnosis of rare adverse effects of drugs is particularly difficult in the presence of multiple organ failure. We present a patient who developed severe adverse effects from linezolid after 23 days' treatment with the recommended dose.CASE PRESENTATIONA male in his seventies with cardiac disease and diabetic nephropathy was admitted to ...
Calvo-Río Vanesa V Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain. - - 2014
Hypersensitivity vasculitis (HV) and Henoch-Schönlein purpura (HSP) are the most common entities included within the category of cutaneous vasculitis (CV). Palpable purpura and histological changes characterised by the presence of leukocytoclastic vasculitis are common in both conditions. Therefore, considerable overlap between them is often seen. It is especially true when ...
Patanè Domenico D 1 Department of Diagnostic and Interventional Radiology, Azienda Ospedaliera per l'Emergenza "Cannizzaro", Catania - - - 2014
<sec id="st1"><title>ABSTRACT</title> <bold><italic>Purpose:</italic></bold> The purpose of this article is to report our experience with drug-eluting balloons for the treatment of juxta-anastomotic stenoses of failing radiocephalic hemodialytic arteriovenous shunt and to evaluate the primary and secondary patency (PP and SP). <bold><italic>Methods:</italic></bold> After approval by the local hospital's Ethical and Scientific Review ...
Gagne Joshua J JJ Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA, - - 2014
Methods for near-real-time monitoring of new drugs in electronic healthcare data are needed. In a novel application, we prospectively monitored ischemic, bleeding, and mortality outcomes among patients initiating prasugrel versus clopidogrel in routine care during the first 2 years following the approval of prasugrel. Using the HealthCore Integrated Research Database, we ...
Nakase Taizen T Department of Stroke Science, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan. Electronic address: - - 2014
Our objective was to investigate the effect of cilostazol in acute therapy for small vessel stroke patients. The neurologic deficits in some patients of small vessel brain infarction will progress even if a patient takes immediate medical treatments including aspirin or other antiplatelet drugs. In Japan, cilostazol, presenting not only ...
Tian Feng F Department of Cardiology, Chinese PLA General Hospital, Beijing, PR - - 2014
Objective: This study aims to assess the characteristics of neointimal hyperplasia after drug-eluting stent (DES) implantation in patients with diabetes mellitus (DM) by optical coherence tomography (OCT). Methods: OCT was performed in 109 patients (45 with DM and 64 without DM) 1 year after DES implantation. Neointimal coverage and thickness ...
Alvarez-Sabín José J Department of Neurology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Background: The mean follow-up in the clinical trials of antiplatelet drugs in the secondary prevention of ischemic atherothrombotic stroke ranges from 1 to 5.5 years. Thus, the safety and efficacy of these drugs in the very long term is not totally documented. We have assessed the safety and effectiveness of ...
Liistro Francesco F 1 Cardiovascular Department - - 2014
Purpose : To test the ability of a drug-eluting balloon (DEB) to reduce recurrent in-stent restenosis (ISR) in diabetic patients with femoropopliteal stents. Methods : A prospective all-comers study [Drug-Eluting Balloon in Peripheral Intervention for In-Stent Restenosis (DEBATE-ISR); ClinicalTrials.gov identifier NCT01558531] of symptomatic diabetic patients with femoropopliteal ISR undergoing treatment ...
Chilipko Allison A AA MedStar Union Memorial Hospital, Baltimore, - - 2014
Objective: The purpose of this study was to evaluate warfarin management by pharmacists compared with physicians through an inpatient anticoagulation management service (AMS).Design: Retrospective cohort study.Setting: Community teaching hospital.Patients, Participants: Patients were randomly selected from the Inpatient AMS from January 1, 2009 to January 1, 2011. Patients were included if ...
Hijazi Omar M OM Department of Cardiac Sciences, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Kingdom of Saudi Arabia. Fax. +966 (11) 8011111 Ext. 16560. E-mail: - - 2014
To compare sedation outcomes for chloral hydrate (CH) and midazolam (MD) as sedative agents for diagnostic procedures in children. A prospective, randomized, double-blinded study conducted between July 2005 and October 2006, at the Pediatric Day Care Unit (DCU), King Abdulaziz Medical City, Riyadh, Saudi Arabia. After meeting the inclusion criteria ...
Aghdaii Nahid N Rajaei Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, - - 2014
Sedation after open heart surgery is important in preventing stress on the heart. The unique sedative features of propofol prompted us to evaluate its potential clinical role in the sedation of post-CABG patients. To compare propofol-based sedation to midazolam-based sedation after coronary artery bypass graft (CABG) surgery in the intensive ...
Shohrati Majid M Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR - - 2014
Ischemic heart disease is the leading cause of death in most societies. In a pathophysiologic point of view, it chiefly results from the formation of thrombus in coronary arteries which could not be only prevented by aspirin. Many of clinical trials have shown the long-term benefits of antiplatelet drugs in ...
Nikbakht Roshan R Department of Obstetrics and Gynecology, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, - - 2014
Preterm labor is the leading cause of infant morbidity and mortality so it may be necessary to administer tocolytics for treatment of it. The aim of this study was to compare the efficacy and safety of magnesium sulfate and nifedipine in the management of preterm labor. 100 women with documented ...
Gupta Mahima M Resident, Department of Anaesthesiology, Father Muller Medical College , Mangalore, India - - 2014
The supplementation of local anaesthetics with adjuvants to improve the efficacy of subarachnoid block has been recognised since long. The most preferred drug has been opioids, but newer drugs like dexmedetomidine has also been introduced and investigated as an effective adjuvant. This study was conducted to evaluate and compare the ...
Afolayan Jide Michael - - 2014
Subarachnoid administration of opioids such as pethidine and fentanyl had been proven safe but that oftramadol has been controversial. Tramadol is cheap and readily available, hence the need to further evaluate its intrathecal safety. The study aimed at determining the hemodynamic and side effect profile of intrathecal tramadol. One hundred ...
Christofaki M M University Hospital of Heraklion, Department of Anesthesiology , P.O. Box 1352, 71110, Crete , - - 2014
Introduction: Postoperative nausea and vomiting (PONV) is associated with poor patient satisfaction and delayed recovery after general anesthesia. Multiple neurotransmitters are involved in the mediation of PONV but despite the introduction of new antiemetics, no completely effective drug exists for its prevention or treatment. Areas covered: This review provides a ...
Thachil Jecko J Central Manchester University Hospitals NHS Foundation Trust, Manchester, - - 2014
Recurrent venous thromboembolism (VTE) occurs in some patients despite treatment with the standard drugs, warfarin and low-molecular-weight heparin (LMWH). Fondaparinux is currently licensed by the Food and Drug Administration for the prophylaxis of deep-vein thrombosis in patients undergoing orthopedic or abdominal surgery and also in the treatment of VTE. Well-documented ...
Chierchia Gian-Battista GB Heart Rhythm Management Center, UZ Brussel-VUB, Laarbbeklaan 101, 1090 Brussels, - - 2014
The novel cryoballoon Advance (CB-A) has proven to achieve significantly lower temperatures and faster pulmonary vein isolation (PVI) times in comparison with the first-generation device. Although acutely very effective, to the best of our knowledge, data on mid-term clinical follow-up is lacking.AIMS: The aim of the study was to analyse ...
Malmi H H Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, - - 2014
The characteristics of peptic ulcer disease (PUD) are changing. To evaluate time trends in the incidence of PUD and its complications in hospitalised patients at the beginning of the 21st century, drug therapies in out-patient care as a risk factor for recurrent PUD, and medication used by PUD patients compared ...
Kim Dong-Kee DK Department of Otolaryngology-Head & Neck Surgery, The Catholic University of Korea, College of Medicine , Seoul , Republic of Korea - - 2014
Abstract Context: Local delivery systems for treatment of intractable inner ear disorders have been attempted by many investigators. Objective: To evaluate the permeability and safety of a drug delivery system for the inner ear using a poly(2-hydroxyethyl aspartamide) (PHEA) polymersome. Materials and methods: One-month-old male C57/BL6 mice were used. We ...
Nie Yuyan Y From the Department of Anesthesiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, - - 2014
Few studies have investigated the use of dexmedetomidine in obstetric anaesthesia. To evaluate the effect of dexmedetomidine combined with sufentanil for patient-controlled analgesia (PCA) after caesarean section under spinal anaesthesia. An interventional, randomised, double-blinded, placebo-controlled clinical study. Department of Anaesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. One ...
Nishio Shoji S Department of Orthopedic Surgery, Hyogo College of Medicine , - - 2014
Thirty-six patients who underwent primary unilateral total hip arthroplasty (THA) were randomly allocated to 4 groups with different pain control protocols; continuous femoral nerve block (FNB group), single-shot caudal epidural block with morphine (EB group), intravenous patient-controlled analgesia with fentanyl (IV-PCA group), and systemic administration of nonsteroidal anti-inflammatory drugs (NSAIDs ...
Sardi Gabriel L GL Division of Cardiology, MedStar Washington Hospital Center, Washington, - - 2014
Patients requiring chronic hemodialysis (HD) are at high risk for restenosis after percutaneous coronary intervention (PCI) with bare metal stents. Outcome data on drug-eluting stent (DES) implantation in HD patients are limited and suggest superiority of paclitaxel-eluting stents (PES) over limus-eluting stents (LES). In total, 218 consecutive patients were prospectively ...
Enriquez Andres A Division of Cardiology, Queen's University, Kingston, Ontario, - - 2014
Management of atrial fibrillation (AF) is hampered by frequent recurrences after restoration of sinus rhythm. Delayed interatrial conduction has been associated with the development of AF in different clinical settings. The aim of our study was to assess whether advanced interatrial block (aIAB) was associated with AF recurrence after pharmacological ...
Puskas John J Department of Cardiothoracic Surgery, Emory University, Atlanta, Ga. Electronic address: - - 2014
Under Food and Drug Administration investigational device exemption, the Prospective Randomized On-X Anticoagulation Clinical Trial (PROACT) has been testing the safety of less aggressive anticoagulation than recommended by the American College of Cardiology/American Heart Association guidelines after implantation of an approved bileaflet mechanical valve. In this first limb of the ...
Owens Christopher D CD Division of Vascular and Endovascular Surgery, University of California San Francisco Medical Center, San Francisco, Calif. Electronic address: - - 2014
Restenosis following endovascular treatment of the femoropopliteal segment is associated with the inflammatory response produced in the artery wall at the time of the procedure. Although local drug delivery to the superficial femoral and popliteal arteries promises improved patency, data are currently limited. We hypothesized that improved percutaneous delivery of ...
Wu Lingmin L State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of - - 2014
The long-term outcome of radiofrequency catheter ablation in persistent atrial fibrillation (AF) patients remains controversial due to different procedural strategies. This study aimed to present the clinical outcome of a pure linear ablation approach without circumferential pulmonary vein isolation (CPVI) over an extended (> 5 years) follow-up period. From January ...
Park Seung-Jung - - 2014
As compared with bare-metal stents, drug-eluting stents (DESs) reduce restenosis in every clinical situation and every type of lesion studied. Therefore, DESs have been in widespread use for more than a decade and are used in the majority of patients receiving intracoronary stents. However, several studies have suggested that early ...
Valente Jonathan H JH Jonathan H. Valente, MD, is an Associate Professor in the Department of Emergency Medicine at The Alpert Medical School of Brown University and Rhode Island Hospital, and Hasbro Children's Hospital, Providence, Rhode Island. Gregory D. Jay, MD, PhD, is a Professor in the Department of Emergency Medicine at The Alpert Medical School of Brown University and Rhode Island Hospital in Providence, Rhode Island. He has received grant/research funding from the NIH and AHRQ in the past and is receiving funding from those same organizations currently. He is a consultant/advisor to Covidien (Mansfield, Massachusetts). Christopher P. Zabbo, DO, is the Program Director of the Emergency Medicine Residency at Kent Hospital in Warwick, Rhode Island, and a Clinical Assistant Professor at the University of New England College of Osteopathic Medicine in the Department of Emergency Medicine at Kent Hospital in Warwick, Rhode Island. Steven E. Reinert, MS, is a Research Analyst at Lifespan Information Services in Providence, Rhode Island. Karina Bertsch, MSW, is the Clinical Research Program Administrator at Rhode Island Hospital in - - 2014
The purpose of this study was to compare cosmesis at 3 to 4 months and infection in simple lacerations irrigated with normal saline (NS) versus activated chlorine dioxide (CD). This was a prospective, randomized trial of a convenience sample of patients. This study was approved by the institutional review board ...
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