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López Mínguez José Ramón JR Hospital Universitario Infanta Cristina, Badajoz, - - 2014
Aims: Paclitaxel drug-eluting balloons (pDEB) could be an attractive option to minimise side branch (SB) restenosis in bifurcated coronary lesions. We compared angiographic and clinical outcomes with pDEB plus bare metal stent (BMS) versus drug-eluting stents (DES) in de novo bifurcated lesions. Methods and results: This multicentre randomised trial included ...
Wójcik Maciej M Department of Cardiology, Kerckhoff Heart and Thorax - - 2014
Background:We analyzed the procedural experience cryoballoon ablation (CBA) of atrial fibrillation (AF) gained over 8 years in a high-volume centre to understand the influence of the learning curve on feasibility, safety and clinical outcome.Methods and Results:In 424 patients (62% male) with drug-refractory AF, CBA was performed between 2005 and 2012. The analyzed ...
Cassinerio E E Rare Disease Center, Department of Medicine and Medical Specialities, "Ca' Granda" Foundation IRCCS Ospedale Maggiore Policlinico, University of Milan, - - 2014
The availability of three iron chelators improved the scenario of chelation therapy for transfusion-dependent thalassemia (TDT) patients, allowing tailoring of drugs according to the goals expected for each patient. The use of Deferiprone/Deferoxamine (DFP/DFO) combined in different schemes has been reported since many years. Only recently data from combination of ...
Liu Junhui J Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, PR - - 2014
Objective: The systematic pro-inflammatory responses after percutaneous coronary intervention with drug-eluting stents (DES) remain poorly defined. Therefore, we compared the systematic pro-inflammatory state of circulating mononuclear cells (MNCs) between DES and bare metal stent (BMS) implantation. Methods: Patients with indications for treatment with stents were randomized in a 1:1 ratio ...
Ota Hideaki H Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United - - 2014
Longitudinal stent deformation (LSD) in drug-eluting stents (DES) has been described as a disruption of stent structure. This study aimed to compare first- versus second-generation DES with respect to their actual stent length post deployment. A total of 617 DES for de novo coronary lesions in 552 patients were analyzed. ...
Willy Mary E ME Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, - - 2014
The objective of this study was to develop metrics to assess opioid prescribing behavior as part of the evaluation of the Extended-Release/Long-Acting (ER/LA) Opioid Analgesic Risk Evaluation and Mitigation Strategies (REMS). Candidate metrics were selected using published guidelines, examined using sensitivity analyses, and applied to cross-sectional rolling cohorts of Medicare ...
Villanueva V V Hospital Universitario y Politécnico La Fe, Valencia, Spain. Electronic address: - - 2014
Eslicarbazepine acetate (ESL) is a new antiepileptic drug (AED) licensed as adjunctive therapy in adults with partial-onset or focal seizures. To evaluate in a clinical practice setting the long-term efficacy and safety of ESL in patients with focal seizures. ESLIBASE was a retrospective study that included all patients with focal ...
Oosterhuis Ingrid I Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH, 's-Hertogenbosch, The Netherlands, - - 2014
Although a concise overview of adverse drug reactions (ADRs) to varenicline is available, little is known about the use of varenicline in daily practice and time-related information about ADRs. The aim of this study was to gain insight in the safety and use of varenicline in daily practice. A prospective, ...
Spirkoska Ana A 1Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, - - 2014
The aim of this study was to follow the thrombus progression and regression in superficial veins of lower limbs in patients with superficial vein thrombosis (SVT) treated with low-molecular-weight heparin. Patients (n = 68) with a first symptomatic SVT of the lower limbs received 2 different dosages of dalteparin. The ...
Shiratori Yoshitaka Y From the Thorax Institute, Department of Cardiology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain (Y.S., S.B., M.S.); Cardiology Department, Interventional Cardiology Unit, Sant Pau Hospital, Barcelona, Spain (C.C., L.A.-C., V.M.-Y., V.M., J.G.-P.); Cardiology Department, Interventional Cardiology Unit, Vall d'Hebron Hospital, Barcelona, Spain (B.G.d.B.); Cardiology Department, Interventional Cardiology Unit, Virgen de Macarena Hospital, Sevilla, Spain (R.R.-S.); Cardiology Department, Interventional Cardiology Unit, Juan Ramon Jimenez Hospital, Huelva, Spain (J.D.); and Cardiology Department, Interventional Cardiology Unit, Virgen de la Arrixaca Hospital, Murcia, Spain - - 2014
Most drug-eluting stents currently in use are coated with a polymer carrying the drug that is released for several weeks. However, a durable polymer may provoke hypersensitive reaction, delayed artery healing, and eventually stent thrombosis. The aim of this study was to investigate the safety and efficacy of a polymer-free ...
Czarny Matthew J MJ Cardiology Division, Department of Medicine, Johns Hopkins Hospital, Baltimore, - - 2014
Adherence to dual antiplatelet therapy (DAPT) is critical after coronary stenting. Although adherence rates are frequently assessed in clinical trials, adherence rates in the unselected population recommended for treatment but beyond clinical trials are largely unknown. Therefore, we performed a systematic review of published observational studies to describe rates of ...
Lo Nathan N Department of Internal Medicine, VA North Texas Healthcare System and University of Texas Southwestern Medical Center, Dallas, - - 2014
The perioperative outcomes of noncardiac surgery in patients who have received second-generation drug-eluting stents (DESs) have received limited study. We reviewed the medical records of 1,748 consecutive patients who received DES at our institution (1,789 procedures) from January 1, 2009, to July 1, 2012, to determine the outcomes of subsequent ...
Mittal Geeta G Department of Anaesthesia, Dayanand Medical College and Hospital, Ludhiana, Punjab, - - 2014
Dexmedetomidine (α2 adrenergic agonist) has been used for prevention of post anaesthesia shivering. Its use for the treatment of post-spinal anaesthesia shivering has not been evaluated. The aim of this study was to evaluate and compare the efficacy, haemodynamic and adverse effects of dexmedetomidine with those of tramadol, when used ...
Sato Kastsumasa K Interventional Cardiology Unit, EMO-GVM Centro Cuore Columbus, Milan, Italy; Fukuyama Cardiovascular Hospital, Fukuyama, Japan. Electronic address: - - 2014
To evaluate the role of integrated backscatter intravascular ultrasound (IB-IVUS) in assessing the morphology of neointima in bare-metal stent (BMS) and drug-eluting stent (DES) restenosis as compared to the gold-standard, optical coherence tomography (OCT). A total of 120 cross-sections were evaluated by IB-IVUS and OCT at five cross-sections from 24 ...
Araki Tadashi T Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan. Electronic address: - - 2014
It is known that drug-eluting stents (DESs) are associated with in-stent restenosis (ISR). However, the characteristics of neointimal tissue components according to the mechanism and time course of DES ISR have not been fully examined. The aim of this study was to characterize the in-stent neointimal tissue components according to ...
Ząbkowski Tomasz T Urology Clinic of the Military Medical Institute, Warszawa, Poland. Electronic address: - - 2014
Benign prostatic hyperplasia (LUTS/BPH) is one of the most common urinary disorders in elderly men. The symptoms of the disease include prostate gland enlargement, bladder outlet obstruction, and lower urinary tract symptoms (LUTSs). BPH predisposes patients to bladder infections and bladder stone formation and increases their risk of urinary retention, ...
Fexer Johannes J Institute of General Practice, Klinikum rechts der Isar der TU M¨nchen, National Association of Statutory Health Insurance Physicians of Bavaria, Munich, Institute of Medical Biometrics, Epidemiology, and Medical Informatics (IMBEI) of the Saarland University, Homburg/Saar, F. Fexer and E. Donnachie share primary authorship of this - - 2014
Theophylline is often used to treat chronic obstructive pulmonary disease (COPD). Current evidence leaves the effectiveness and safety of this drug open to question. Thus, we evaluated the effectiveness of theophylline on the rate of hospitalizations and disease exacerbations by examining routine data from the ambulatory disease management program for ...
Ribeiro Expedito E EE Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, - - 2014
Aims: The INSPIRON-I trial is a first-in-man evaluation of the safety and efficacy of the Inspiron drug-eluting stent, a sirolimus-eluting stent with abluminal biodegradable polymer coating and thin cobalt-chromium alloy. Methods and results: This is a randomised, multicentre comparison between Inspiron and a stent with the same metallic structure but ...
Wang Yifan Y Department of Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, - - 2014
Background: Matrix metalloproteinases (MMPs) are supposed to be potential drug targets to prevent leakage after colonic anastomosis. A method of colonic anastomosis by using a stent coated with doxycycline, a MMP inhibitor, was developed and its safety and feasibility, as well as the effect of locally regulating MMPs, were evaluated ...
Blomquist J J Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway; Department of Surgery, Haraldsplass Deaconess Hospital, Bergen, - - 2014
To achieve pain control after arthroscopic shoulder surgery, nonsteroidal anti-inflammatory drugs (NSAIDs) are a complement to other analgesics. However, experimental studies have raised concerns that these drugs may have a detrimental effect on soft tissue-to-bone healing and, thus, have a negative effect on the outcome. We wanted to investigate if ...
Curtis Jeffrey R JR University of Alabama at Birmingham, Birmingham, - - 2014
Abstract Objectives: To estimate biologic cost per effectively treated patient with rheumatoid arthritis (RA) using a claims-based algorithm for effectiveness. Methods: Patients with RA aged 18 to 63 years in the IMS PharMetrics(™) Plus database were categorized as effectively treated if they met all six criteria: (1) a medication possession ...
Chamberlain Marc C MC Seattle Cancer Care Alliance, Fred Hutchinson Cancer Center, University of Washington, 825 Eastlake Ave E, MS: G4-940, Seattle, WA, 98109, USA, - - 2014
Treatment options are limited for recurrent glioblastoma (GBM). Verubulin is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals. Adults with recurrent GBM who failed prior standard therapy were eligible. The primary endpoint was 1-month progression-free survival (PFS-1) for bevacizumab refractory (Group ...
Doosti Afsaneh A Audiology Department, University of Social Welfare and Rehabilitation Sciences, P.O. Box 1985713834, Velenjak, Tehran, - - 2014
Distortion product otoacoustic emission (DPOAE) appears to be an objective sensitive test of cochlear function. The aim of this study was to investigate whether DPOAE is an appropriate tool for assessment of minute changes in cochlea due to usage of antioxidant material. 48 workers exposed to continuous noise in a ...
Marmagkiolis Konstantinos K Citizens Memorial Hospital Heart and Vascular Institute, Bolivar, - - 2014
Background: Endovascular approach to superficial femoral artery (SFA) disease, the most common cause of symptomatic PAD, remains fraught with high failure rates. Newer devices including second-generation nitinol stents, drug-coated stents, drug-coated balloons, covered stents, cryo-therapy, LASER and directional atherectomy, have shown promising results. Clinical equipoise still persists regarding the optimal ...
Park Ji Young JY Division of Gastroenterology, Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Republic of - - 2014
Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). The aim of this prospective trial was to compare the effect of ulinastatin and nafamostat on the prophylaxis of post-ERCP complications. A total of 159 patients who underwent ERCP were divided into ulinastatin (n = 53), nafamostat (n = 53) and control (n = 53) ...
Juma James M - - 2014
In Tanzania, routine individual-level testing for HIV drug resistance (HIVDR) using laboratory genotyping and phenotyping is not feasible due to resource constraints. To monitor the prevention or emergence of HIVDR at a population level, WHO developed generic strategies to be adapted by countries, which include a set of early warning ...
Englberger Lars L From the *Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland; †Department of Anesthesiology, Working Group of Perioperative Hemostasis, University of Munich, Munich, Germany; and ‡Department of Anesthesiology and Pain Therapy, University Hospital Berne, Berne, - - 2014
Antifibrinolytics have been used for 2 decades to reduce bleeding in cardiac surgery. MDCO-2010 is a novel, synthetic, serine protease inhibitor. We describe the first experience with this drug in patients. In this phase II, double-blind, placebo-controlled study, 32 patients undergoing isolated primary coronary artery bypass grafting with cardiopulmonary bypass ...
Hayashi Meiso M Department of Cardiovascular Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, - - 2014
Atrial tachyarrhythmias (AT) commonly recur within the first 3 months after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF), and the influence of antiarrhythmic drugs (AADs) on the recurrences has not been fully elucidated. We sought to evaluate the efficacy of a 3-month lower-dose flecainide regime on early and late ...
Incorvaia C C Pulmonary Rehabilitation Unit, Istituti Clinici di Perfezionamento, Presidio Ospedaliero CTO, Milan, Italy - - - 2014
Chronic obstructive pulmonary disease (COPD) causes an impairment of respiratory function, well reflected by the progressive decrease in forced expiratory volume in 1 second (FEV1). The only interventions able to slow down the FEV1 decline are smoking cessation and drug treatment. Pulmonary rehabilitation (PR), is claimed to improve exercise tolerance, ...
Fanelli F F Unit of Vascular and Interventional Radiology Department of Radiological Sciences "Sapienza" University of Rome, Rome, Italy - - - 2014
The aim of the present paper was to make a report of the 12-month clinical outcomes of the DEBELLUM (Drug-Eluting-Balloon-Evaluation-for-Lower-Limb- mUltilevel-treatMent) randomized trial. From September 2010 to March 2011, 50 patients were randomized between drug eluting balloon (DEB, N.=25) and conventional angioplasty balloon (PTA, N.=25). Patients were symptomatic for claudication ...
De Luca Giuseppe G Division of Cardiology, Ospedale "Maggiore della Carità", Eastern Piedmont University, C.so Mazzini, 18, 24100, Novara, Italy, - - 2014
Several concerns have emerged on the higher risk of in-stent thrombosis after drug-eluting stent (DES) implantation, especially in the setting of STEMI patients. Few data have even been reported in high-risk patients, such as those with anterior MI. Therefore this represents the aim of the current study. The literature was ...
Kim Kyungmi K Department of Anaesthesia and Pain Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of - - 2014
The efficacy and side-effects of nefopam were prospectively compared with those of fentanyl for patient-controlled analgesia (PCA) following cardiac surgery. Patients scheduled to undergo cardiac surgery were randomly assigned between three PCA groups (nefopam, fentanyl or nefopam + fentanyl). Pain was assessed at rest and during movement at 12, 24, ...
Barbash Israel M IM MedStar Washington Hospital Center, 110 Irving Street, NW, Suite 4B-1, Washington, DC 20010 USA. - - 2014
This study aimed to assess the long-term safety and clinical effectiveness of the Xience V everolimus-eluting stent (EES) compared to both Taxus paclitaxel-eluting stent (PES) and Cypher sirolimus-eluting stent (SES) in an unselected patient population. There are limited long-term data comparing Xience V EES vs the first-generation Cypher SES. This ...
Romaguera Rafael R Hospital Universitari de Bellvitge, Heart Diseases Institute, Feixa Llarga s/n, Barcelona, 08907, Spain. - - 2014
Some modifications introduced in the design of the new generation of drug-eluting stent (DES) to improve their flexibility may entail a reduction in their longitudinal strength. This study sought to evaluate the longitudinal deformation of DESs by multislice computed tomography (MSCT). This study included DESs that could have been potentially ...
Kiviniemi Tuomas T Heart Center, Turku University Hospital and University of Turku, Finland. Electronic address: - - 2014
The hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, and drugs/alcohol (HAS-BLED); anticoagulation and risk factors in atrial fibrillation (ATRIA); modified Outpatient Bleeding Risk Index (mOBRI); and reduction of atherothrombosis for continued health (REACH) schemes are validated bleeding risk-prediction tools, but their predictive performance ...
Potdar Meenoti Pramod MP Department of Anaesthesia, Dr. Lakhumal Hiranand Hiranandani Hospital, Powai, Mumbai, Maharashtra, - - 2014
Cost and environmental pollution are two prime concerns with general anesthesia. We hypothesized that target-controlled (TC) anesthesia drug delivery system also called as end-tidal (ET) control is an effective and safe system that would reduce the cost and also environmental pollution. We studied 200 patients undergoing laparoscopic abdominal and pelvic ...
Choudhary Sanjiv V SV Department of Dermatology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, - - 2014
To study and compare the efficacy and safety of topical terbinafine hydrochloride 1% cream and eberconazole nitrate 1% cream in localized tinea corporis and cruris. Patients were randomized after considering various inclusion and exclusion criteria into two groups. Group A (treated with terbinafine 1% cream for 3 weeks) and group ...
Gottumukkala Sruthima N V S SN Department of Periodontics, Vishnu Dental College, Bhimavaram, Andhra Pradesh, - - 2014
To comparatively evaluate the therapeutic efficacy of chlorhexidine (CHX) chips (Periocol-CG) and indigenous curcumin (CU) based collagen as adjuncts to scaling and root planning in the nonsurgical management of chronic periodontitis. A total of 120 sites from 60 patients presenting with chronic periodontitis (age group 25-55 years) of both sexes, ...
Abtahi M M Department of Orthodontics and Dental Material Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, - - 2014
Introduction: While there are a growing number of studies on the effects of medications on orthodontic tooth movement (OTM), only few studies have investigated the role of corticosteroids, despite their widespread use. The aim of the current study was to evaluate the effects of triamcinolone acetonide injection on OTM in ...
Natarajan Surendar M M Department of Pedodontics and Preventive Dentistry, From King George's Medical University, Lucknow, - - 2014
Objectives: To evaluate and compare the efficacy and safety of Intranasal (IN) Dexmedetomidine, Midazolam and Ketamine in producing moderate sedation among uncooperative pediatric dental patients. Study Design: This randomized triple blind comparative study comprises of eighty four ASA grade I children of both sexes aged 4-14 years, who were uncooperative ...
Bhangu Aneel A Department of Colorectal Surgery, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK, - - 2014
Enhanced recovery programs following colorectal resection recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) as part of multimodal analgesia. The present study aimed to assess whether postoperative NSAID use increased the risk of anastomotic leak. A systematic review of published literature was performed for studies comparing anastomotic leak following NSAID ...
Carretero G G Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, - - 2014
Biobadaderm is the Spanish registry of psoriasis patients receiving systemic treatment in clinical practice. To compare the safety of biologics and classic systemic treatment. Prospective cohort of patients receiving biologics and classic systemic therapies between 2008 and 2013 in 12 hospitals are included. We registered demographic data, diagnoses, comorbidities, treatments ...
Bassaw B B Department of Obstetrics and Gynaecology, Mt. Hope Maternity Hospital , Trinidad , West - - 2014
The aim of this randomised prospective study was to investigate the impact of preoperative gonadotrophin-releasing hormone agonist (GnRHa) compared with a control group with myomectomy. A total of 36 women (n = 36, group 1) with fibroids were randomised to receive either 2 monthly doses (n = 18/36, group 1a) ...
Murgier J J Service d'orthopédie-traumatologie, institut de l'appareil locomoteur, hôpital Pierre-Paul-Riquet, 308, avenue de Grande-Bretagne, 31059 Toulouse, France. Electronic address: - - 2014
Cryotherapy is a useful adjunctive analgesic measure in patients with postoperative pain following anterior cruciate ligament (ACL) surgery. Either static permanent compression or dynamic intermittent compression can be added to increase the analgesic effect of cryotherapy. Our objective was to compare the efficacy of these two compression modalities combined with ...
García-García Hector M HM Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The - - 2014
To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. In a multi-centre study, 141 patients ...
Giovanni Giacomo DI GD From the Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, - - 2014
With respect to the first generation Cryoballoon (CB), the second generation (Cryoballoon Advance; Medtronic, USA; CB-A) was designed with technical modifications resulting in a larger and more uniform zone of freezing on the balloons surface aiming at procedural outcome improvement in the setting of atrial fibrillation (AF) ablation. However a ...
Jim Man-Hong MH Cardiac Medical Unit, Grantham Hospital, 125 Wong Chuk Hang Road, Hong Kong, China, - - 2014
The aim of this study was to examine the mid-term angiographic result of T-stenting with small protrusion (TAP) as the bailout strategy for treating coronary bifurcation lesions. From 2009 to 2012, symptomatic patients who had severe coronary bifurcation stenoses were treated with one-stent strategy using drug-eluting stents, with kissing balloon ...
Maeng Michael M Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark. Electronic address: - - 2014
In head-to-head comparisons of coronary drug-eluting stents, the primary endpoint is traditionally assessed after 9-12 months. However, the optimum timepoint for this assessment remains unclear. In this study, we assessed clinical outcomes at up to 5 years' follow-up in patients who received two different types of drug-eluting stents. We undertook ...
Zhang Lei L Department of Cardiology, Shenyang Northern Hospital, Shenyang, - - 2014
The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation remains controversial. The primary aim of our study was to evaluate the impact of optimal DAPT duration on bleeding events between 6 and 12 months after biodegradable polymer-coated DES implantation. The secondary aim is to determine the ...
Costa D D Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra 08193, Barcelona, - - 2014
The objective of this study was to describe and compare the efficacy and duration of topical anaesthesia induced by 2 per cent lidocaine (L), 0.5 per cent bupivacaine (B) and 1 per cent ropivacaine (R) in the dog using 24 clinically healthy beagles with normal ocular examination. Dogs were randomly ...
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