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Chilipko Allison A AA MedStar Union Memorial Hospital, Baltimore, - - 2014
Objective: The purpose of this study was to evaluate warfarin management by pharmacists compared with physicians through an inpatient anticoagulation management service (AMS).Design: Retrospective cohort study.Setting: Community teaching hospital.Patients, Participants: Patients were randomly selected from the Inpatient AMS from January 1, 2009 to January 1, 2011. Patients were included if ...
Hijazi Omar M OM Department of Cardiac Sciences, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Kingdom of Saudi Arabia. Fax. +966 (11) 8011111 Ext. 16560. E-mail: - - 2014
To compare sedation outcomes for chloral hydrate (CH) and midazolam (MD) as sedative agents for diagnostic procedures in children. A prospective, randomized, double-blinded study conducted between July 2005 and October 2006, at the Pediatric Day Care Unit (DCU), King Abdulaziz Medical City, Riyadh, Saudi Arabia. After meeting the inclusion criteria ...
Aghdaii Nahid N Rajaei Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, - - 2014
Sedation after open heart surgery is important in preventing stress on the heart. The unique sedative features of propofol prompted us to evaluate its potential clinical role in the sedation of post-CABG patients. To compare propofol-based sedation to midazolam-based sedation after coronary artery bypass graft (CABG) surgery in the intensive ...
Gupta Mahima M Resident, Department of Anaesthesiology, Father Muller Medical College , Mangalore, India - - 2014
Background: The supplementation of local anaesthetics with adjuvants to improve the efficacy of subarachnoid block has been recognised since long. The most preferred drug has been opioids, but newer drugs like dexmedetomidine has also been introduced and investigated as an effective adjuvant. Aim: This study was conducted to evaluate and ...
Shohrati Majid M Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR - - 2014
Ischemic heart disease is the leading cause of death in most societies. In a pathophysiologic point of view, it chiefly results from the formation of thrombus in coronary arteries which could not be only prevented by aspirin. Many of clinical trials have shown the long-term benefits of antiplatelet drugs in ...
Christofaki M M University Hospital of Heraklion, Department of Anesthesiology , P.O. Box 1352, 71110, Crete , - - 2014
Introduction: Postoperative nausea and vomiting (PONV) is associated with poor patient satisfaction and delayed recovery after general anesthesia. Multiple neurotransmitters are involved in the mediation of PONV but despite the introduction of new antiemetics, no completely effective drug exists for its prevention or treatment. Areas covered: This review provides a ...
Thachil Jecko J Central Manchester University Hospitals NHS Foundation Trust, Manchester, - - 2014
Recurrent venous thromboembolism (VTE) occurs in some patients despite treatment with the standard drugs, warfarin and low-molecular-weight heparin (LMWH). Fondaparinux is currently licensed by the Food and Drug Administration for the prophylaxis of deep-vein thrombosis in patients undergoing orthopedic or abdominal surgery and also in the treatment of VTE. Well-documented ...
Chierchia Gian-Battista GB Heart Rhythm Management Center, UZ Brussel-VUB, Laarbbeklaan 101, 1090 Brussels, - - 2014
The novel cryoballoon Advance (CB-A) has proven to achieve significantly lower temperatures and faster pulmonary vein isolation (PVI) times in comparison with the first-generation device. Although acutely very effective, to the best of our knowledge, data on mid-term clinical follow-up is lacking.AIMS: The aim of the study was to analyse ...
Malmi H H Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, - - 2014
The characteristics of peptic ulcer disease (PUD) are changing. To evaluate time trends in the incidence of PUD and its complications in hospitalised patients at the beginning of the 21st century, drug therapies in out-patient care as a risk factor for recurrent PUD, and medication used by PUD patients compared ...
Kim Dong-Kee DK Department of Otolaryngology-Head & Neck Surgery, The Catholic University of Korea, College of Medicine , Seoul , Republic of Korea - - 2014
Abstract Context: Local delivery systems for treatment of intractable inner ear disorders have been attempted by many investigators. Objective: To evaluate the permeability and safety of a drug delivery system for the inner ear using a poly(2-hydroxyethyl aspartamide) (PHEA) polymersome. Materials and methods: One-month-old male C57/BL6 mice were used. We ...
Nie Yuyan Y From the Department of Anesthesiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, - - 2014
Few studies have investigated the use of dexmedetomidine in obstetric anaesthesia. To evaluate the effect of dexmedetomidine combined with sufentanil for patient-controlled analgesia (PCA) after caesarean section under spinal anaesthesia. An interventional, randomised, double-blinded, placebo-controlled clinical study. Department of Anaesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. One ...
Nishio Shoji S Department of Orthopedic Surgery, Hyogo College of Medicine , - - 2014
Thirty-six patients who underwent primary unilateral total hip arthroplasty (THA) were randomly allocated to 4 groups with different pain control protocols; continuous femoral nerve block (FNB group), single-shot caudal epidural block with morphine (EB group), intravenous patient-controlled analgesia with fentanyl (IV-PCA group), and systemic administration of nonsteroidal anti-inflammatory drugs (NSAIDs ...
Sardi Gabriel L GL Division of Cardiology, MedStar Washington Hospital Center, Washington, - - 2014
Patients requiring chronic hemodialysis (HD) are at high risk for restenosis after percutaneous coronary intervention (PCI) with bare metal stents. Outcome data on drug-eluting stent (DES) implantation in HD patients are limited and suggest superiority of paclitaxel-eluting stents (PES) over limus-eluting stents (LES). In total, 218 consecutive patients were prospectively ...
Enriquez Andres A Division of Cardiology, Queen's University, Kingston, Ontario, - - 2014
Management of atrial fibrillation (AF) is hampered by frequent recurrences after restoration of sinus rhythm. Delayed interatrial conduction has been associated with the development of AF in different clinical settings. The aim of our study was to assess whether advanced interatrial block (aIAB) was associated with AF recurrence after pharmacological ...
Puskas John J Department of Cardiothoracic Surgery, Emory University, Atlanta, Ga. Electronic address: - - 2014
Under Food and Drug Administration investigational device exemption, the Prospective Randomized On-X Anticoagulation Clinical Trial (PROACT) has been testing the safety of less aggressive anticoagulation than recommended by the American College of Cardiology/American Heart Association guidelines after implantation of an approved bileaflet mechanical valve. In this first limb of the ...
Owens Christopher D CD Division of Vascular and Endovascular Surgery, University of California San Francisco Medical Center, San Francisco, Calif. Electronic address: - - 2014
Restenosis following endovascular treatment of the femoropopliteal segment is associated with the inflammatory response produced in the artery wall at the time of the procedure. Although local drug delivery to the superficial femoral and popliteal arteries promises improved patency, data are currently limited. We hypothesized that improved percutaneous delivery of ...
Wu Lingmin L State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of - - 2014
The long-term outcome of radiofrequency catheter ablation in persistent atrial fibrillation (AF) patients remains controversial due to different procedural strategies. This study aimed to present the clinical outcome of a pure linear ablation approach without circumferential pulmonary vein isolation (CPVI) over an extended (> 5 years) follow-up period. From January ...
Park Seung-Jung - - 2014
As compared with bare-metal stents, drug-eluting stents (DESs) reduce restenosis in every clinical situation and every type of lesion studied. Therefore, DESs have been in widespread use for more than a decade and are used in the majority of patients receiving intracoronary stents. However, several studies have suggested that early ...
Valente Jonathan H JH Jonathan H. Valente, MD, is an Associate Professor in the Department of Emergency Medicine at The Alpert Medical School of Brown University and Rhode Island Hospital, and Hasbro Children's Hospital, Providence, Rhode Island. Gregory D. Jay, MD, PhD, is a Professor in the Department of Emergency Medicine at The Alpert Medical School of Brown University and Rhode Island Hospital in Providence, Rhode Island. He has received grant/research funding from the NIH and AHRQ in the past and is receiving funding from those same organizations currently. He is a consultant/advisor to Covidien (Mansfield, Massachusetts). Christopher P. Zabbo, DO, is the Program Director of the Emergency Medicine Residency at Kent Hospital in Warwick, Rhode Island, and a Clinical Assistant Professor at the University of New England College of Osteopathic Medicine in the Department of Emergency Medicine at Kent Hospital in Warwick, Rhode Island. Steven E. Reinert, MS, is a Research Analyst at Lifespan Information Services in Providence, Rhode Island. Karina Bertsch, MSW, is the Clinical Research Program Administrator at Rhode Island Hospital in - - 2014
The purpose of this study was to compare cosmesis at 3 to 4 months and infection in simple lacerations irrigated with normal saline (NS) versus activated chlorine dioxide (CD). This was a prospective, randomized trial of a convenience sample of patients. This study was approved by the institutional review board ...
Divoky Laura L Department of Internal Medicine, Summa Health System, 75 Arch St, Suite #501, Akron, OH 44304-1424. - - 2014
Myopericarditis occurs in 15% of patients with pericarditis. Recurrent myopericarditis occurs in 15% to 30% of patients after partial or complete recovery from acute myopericarditis. Relapse often occurs within 1 month of an initial episode. The standard of care for pericarditis or myopericarditis is initial treatment with nonsteroidal anti-inflammatory drugs ...
Gilbert Erin - - 2014
There are numerous dermal fillers available to injectors in the US and Europe for the correction of age-related volume loss in the midface and perioral regions. Product availability differs between these two aesthetic markets due to US Food and Drug Administration (FDA) regulatory requirements. The purpose of this study is ...
Obal Detlef D Department of Anesthesiology and Perioperative Medicine and the Center for Diabetes and Obesity Research, University of Louisville, Louisville, KY. Electronic address: - - 2014
To test the primary hypothesis that ondansetron or dolasetron extends the rate-corrected QT electrocardiographic interval (QTc) greater than 60 milliseconds or increases the fraction of patients with QTc greater than 500 milliseconds in patients having noncardiac surgery, and the secondary hypothesis that QTc prolongation is worse in diabetic patients. We ...
Cevik Arif A AA Department of Emergency Medicine, Eskisehir Osmangazi University, Meselik, Eskisehir, - - 2014
The aim of our study was to evaluate the effect of lactate level (LL) and shock index (SI) on the outcome in nontraumatic hypotensive patients in the emergency department, and also to show the significance of the combined usage of these two parameters. This is a prospective, observational study. Elevated ...
Ascioglu Sibel S Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of - - 2014
Both caspofungin and voriconazole were initially approved by the FDA with very narrow indications. Our aim was to evaluate the utilization patterns and comparative effectiveness of these agents early after marketing before any labeling change occurred. This was a retrospective cohort study utilizing a large healthcare database in the United ...
Sivrikoz Nükhet N Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul, - - 2014
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. The purpose of this study was to evaluate the postoperative pain relief and opioid-sparing effects of dexketoprofen and lornoxicam after major orthopedic surgery. Methods: After obtaining ethical committee approval and informed consent, 120 patients undergoing elective hip or ...
Eris Cuneyt C Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Education and Research Hospital Bursa, - - 2014
Levosimendan (LS) is a new inotropic drug which belongs to the group of drugs known as calcium sensitizers. It is different from other inotropic agents by its inotropic and vasodilatory actions without an increase in myocardial oxygen consumption and considered as a good choice in high-risk patients undergoing cardiac surgery. ...
Mandal Pragnadyuti P Department of Pharmacology, Midnapore Medical College, Paschim Medinipur, West Bengal, - - 2014
Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. The study was carried out to compare the efficacy of ginger (Zingiber officinale) added to Ondansetron in preventing PONV after ambulatory surgery. It was a prospective, double blinded, and ...
Isitemiz Ilke I Department of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, - - 2014
Background In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. Material and Methods This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia ...
Shah B B Chief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, - - 2014
Levosimendan is a calcium sensitizer drug which has been used in cardiac surgery for the prevention of postoperative low cardiac output syndrome (LCOS) and in difficult weaning from cardiopulmonary bypass (CPB). This study aims to evaluate perioperative hemodynamic effects of levosimendan pretreatment in patients for off-pump coronary artery bypass graft ...
Deshpande N V NV Director-Cardiac Cath Lab, Spandan Heart Institute and Research Center, Nagpur, - - 2014
Drug eluting stents have remarkably improved results of percutaneous coronary angioplasty. Most of the currently available drug eluting stents uses a durable polymer as drug carrier which has been implicated in local inflammatory response and continued incidence of late and very late stent thrombosis. The Pronova XR stent is one ...
Robati Shibby S Department of Trauma and Orthopaedics, East Kent University Hospitals, Margate, - - 2014
A 72-year-old woman was admitted for a routine elective total knee replacement. By day 1 postoperative, she became hyponatraemic following an Addisonian crisis, leading to an admission into the intensive therapy unit (ITU). It was later during this stay in the ITU and on a retrospective drug history review that ...
Kuramitsu Shoichi S Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, - - 2014
Stent fracture (SF) after drug-eluting stent implantation has become an important concern. The aim of this study was to assess the incidence, predictors, and clinical impact of SF after biolimus-eluting stent. A total of 1026 patients with 1407 lesions undergoing the Nobori biolimus-eluting stent implantation and follow-up angiography within 9 ...
Fallah Razieh R Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ; Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, - - 2014
Infantile spasms (IS) are among the most catastrophic epileptic syndromes of infancy. The purpose of this study was to compare efficacy and safety of topiramate (TPM) and nitrazepam (NZP) as first-line drugs in the treatment of IS. In a parallel single-blinded randomized clinical trial, 50 patients with IS referred to ...
Kaja Sriramamurthy S Department of Anesthesia, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, - - 2014
Post-operative nausea and vomiting is one of the most common and distressing complications after anesthesia and surgery. It may lead to serious post-operative complications. Ramosetron is a newer 5-HT3 receptor antagonist and has more potent and longer duration of antiemetic effects compared to first generation 5HT3 receptor antagonists. The purpose ...
Casaroli-Marano Ricardo R 0000-0002-1431-4874 Instituto Clinic de Oftalmología, Hospital Clínic de Barcelona, Universitat de Barcelona, Carrer Sabino Arana 1, 08028 Barcelona, - - 2014
Purpose. To survey the management of patients with neovascular age-related macular degeneration (nvAMD) in Spain. Methods. An observational retrospective multicenter study was conducted. The variables analyzed were sociodemographic characteristics, foveal and macular thickness, visual acuity (VA), type of treatment, number of injections, and the initial administration of a loading dose ...
Tewari Anurag A Department of Anesthesiology, Dayanand Medical College, Ludhiana, - - 2014
Under regional anesthesia, geriatric patients are prone to shivering induced perioperative complications that Anesthesiologists should prevent rather than treat. We investigated the prophylactic efficacy of oral tramadol 50 mg to prevent the perioperative shivering after transurethral resection of prostate (TURP) surgery under subarachnoid blockade (SAB). Shivering is usually overlooked in ...
Yoganarasimha N N Department of Anaesthesiology, Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka, - - 2014
Spinal anaesthesia requires a small volume of drug to produce profound reproducible sensory analgesia and motor blockade, but has limited duration of action. A properly chosen adjuvant to local anaesthetic agent produces the best way to achieve a better quality regional block. Hence, a study was conducted to compare the ...
Durand Eric E From the Cardiology Department, European Georges Pompidou Hospital, Paris Centre de Recherche Cardiovasculaire, INSERM U 970, Université Paris-Descartes, Paris, France (E.D., M.R., A.L.); Faculty of Pharmacy, Institut Charles Gherardt, MACS (T.S.) UMR CNRS 5253 and Faculty of Pharmacy, Research Center for Artificial Biopolymers, Institut de Biomolecules Max Mousseron, University Montpellier 1-CNRS, Montpellier, France (M.V.); AccelLAB Inc, Boisbriand, Quebec, Canada (G.L.); and Arterial Remodeling Technologies, Noisy le Roi, France - - 2013
We aimed to evaluate a new drug-free fully bioresorbable lactic acid-based scaffold designed to allow early dismantling synchronized with artery wall healing in comparison with a bare metal stent (BMS). Twenty-three BMS (3.0×12 mm) and 36 lactic acid-based bioresorbable scaffolds (BRS, 3.0×11 mm) were implanted in porcine coronary arteries. QCA ...
Alfonso Fernando F Hospital Universitario de la Princesa, Madrid, Spain; Hospital Universitario Clínico San Carlos, Madrid, Spain. Electronic address: - - 2013
We sought to compare the efficacy of drug-eluting balloons (DEB) and everolimus-eluting stents (EES) in patients with bare-metal stent (BMS) in-stent restenosis (ISR). Treatment of patients with ISR remains a challenge. This was a prospective, multicenter, randomized trial comparing DEB and EES in patients with BMS-ISR. The primary end-point was ...
van Zellem Lennart L 1Division of Paediatric Intensive Care, Department of Paediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. 2Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The - - 2013
To investigate whether analgesic and sedative drug use during PICU treatment is associated with long-term neurodevelopmental outcome in children who survived meningococcal septic shock. This study concerned a secondary analysis of data from medical and psychological follow-up of a cross-sectional cohort of all consecutive surviving patients with septic shock and ...
Villwock Jennifer A JA Department of Otolaryngology, SUNY Upstate Medical University, Syracuse, New - - 2013
The timing of tracheostomy in stroke patients unable to protect their airway has become a topic of debate. Proponents for early tracheostomy (ET) cite benefits including less ventilation-associated pneumonia, less sedative drug use, shorter length of stay, and reduced mortality in comparison with late tracheostomy (LT). We examined the timing ...
Zhang Peng P Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, 050051, - - 2013
To determine the outcome and safety of surgical treatment of thoracic and lumbar spinal tuberculosis in patients without obvious clinical and laboratory improvement after preoperative short-time chemotherapy. Data of 86 patients with single-level thoracic and lumbar tuberculosis, treated by one-stage posterior instrumentation combined with anterior radical debridement and fusion, were ...
Baek Chung Hee CH Division of Nephrology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine, Seoul, Republic of - - 2014
Cardiovascular disease is an important cause of death in patients with end-stage renal disease. Although coronary artery bypass graft (CABG) surgery and drug-eluting stent (DES) implantation have been compared in chronic hemodialysis patients, the results are unclear. The study population consisted of chronic hemodialysis patients (dialysis duration >6 months) with coronary ...
Puustinen Juha J Department of Family Medicine, University of Turku, Lemminkäisenkatu 1, 20014, Turku, Finland, - - 2013
The aim of this study was to assess the effect of withdrawal from the long-term use of temazepam, zopiclone or zolpidem as hypnotics drugs (here referred to as BZD) on cognitive performance. Ninety-two adults (age ≥55 years) with primary insomnia and who were long-term daily users of BZD volunteered to participate ...
Hajjej Zied Z Intensive Care Unit, Military Hospital of Tunis, 1008 Montfleury, Tunis, Tunisia. Electronic address: - - 2013
Although there are many studies about catheter related infection in industrialized countries, very few have analyzed it in emerging countries. The aim of our study was to determine the incidence, microbiological profile and risk factors for catheter-related bloodstream infection (CRBSI) in a Tunisian medical intensive care unit. Over eight months ...
Tercan Mehmet M Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, - - 2014
We aimed to investigate the effects of metoclopramide and ondansetrone on mivacurium neuromuscular blockade. Seventy five, ASA I-II patients, aged 18-65 and scheduled for elective surgery requiring tracheal intubation were included in the study. The patients received metoclopramide 10mg, ondansetrone 4mg or normal saline 5mL; group M, group O, group ...
Kimmons Lauren A - - 2013
Dabigatran etexilate, an oral direct thrombin inhibitor, was approved by the Food and Drug Administration to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation based on the outcomes of the Randomized Evaluation of Long-term anticoagulant therapY (RE-LY) study. Although this study provides robust data ...
Vreden Stephen Gs SG Foundation for Scientific Research Suriname, Suriname, - - 2013
The emerging resistance to artemisinin derivatives that has been reported in South-East Asia led us to assess the efficacy of artemether-lumefantrine as the first line therapy for uncomplicated Plasmodium falciparum infections in Suriname. This drug assessment was performed according to the recommendations of the World Health Organization in 2011. The ...
Valgimigli Marco M Cardiology Department, University of Ferrara, Ferrara, Italy. Electronic address: - - 2013
This study sought to assess device-specific outcomes after implantation of bare-metal stents (BMSs), zotarolimus-eluting Endeavor Sprint stents (ZES-Ss), paclitaxel-eluting stents (PESs), or everolimus-eluting stents (EESs) (Medtronic Cardiovascular, Santa Rosa, CA) in all-comer patients undergoing percutaneous coronary intervention. Few studies have directly compared second-generation drug-eluting stents with each other or with ...
Holland Professor Richard - - 2013
Supervised consumption of opioid maintenance treatment (OMT) is standard in many drug centres reducing drug diversion, but is costly. We aimed to determine whether supervised consumption of OMT improved retention and other measures of drug use. Pragmatic randomised controlled trial comparing three months of daily supervised consumption of OMT with ...
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