Search Results
Results 451 - 500 of 1398
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Hreinsson Jóhann P - - 2012
OBJECTIVES: To investigate the incidence and outcomes of acute lower gastrointestinal bleeding (ALGIB) in a population-based setting and examine the role of drugs potentially associated with GIB. METHODS: The study was prospective and population based. The cohort included all patients who underwent colonoscopy during the year 2010 at the National ...
Silva Rufino - - 2013
To evaluate long-term safety of intravitreal ranibizumab 0.5-mg injections in neovascular age-related macular degeneration (nAMD). Twenty-four-month, open-label, multicenter, phase IV extension study. Two hundred thirty-four patients previously treated with ranibizumab for 12 months in the EXCITE/SUSTAIN study. Ranibizumab 0.5 mg administered at the investigator's discretion as per the European summary ...
Takahashi Daisuke - - 2012
OBJECTIVES: Non-steroidal anti-inflammatory drugs play a major role in the management of osteoarthritis (OA). However, it remains unknown whether these drugs affect cartilage and synovial metabolism in osteoarthritic joints. The aim of this study was to evaluate the effects of a selective cyclooxygenase (COX)-2 inhibitor, celecoxib, on synovial fluids and ...
Chiba Miho - - 2012
AIM: Liver cirrhosis is often accompanied by zinc deficiency. The exact mechanisms underlying zinc deficiency remain unclear. This study was undertaken to clarify the influence of diuretics on blood zinc levels and zinc excretion in urine in liver cirrhosis. METHODS: Seventy-nine outpatients with liver cirrhosis were divided into four groups: ...
Chevalier Bernard - - 2012
Objectives : We compared the efficacy of the Cypher Select™ (Cordis Corporation, Bridgewater, NJ, USA) sirolimus-eluting stent (SES) versus balloon angioplasty (BA) in in-stent restenosis (ISR) of Taxus™ or Taxus Liberté™ paclitaxel-eluting stents (PES; Boston Scientific, Natick, MA, USA) or Cypher/Cypher Select SES. Background : Optimal treatment strategies have not been identified ...
Gaztañaga Larraitz - - 2012
BACKGROUND: Outcome after atrial fibrillation (AF) recurrence following ablation remains poorly characterized. OBJECTIVE: To determine whether the time to recurrence of AF after catheter ablation impacts outcome. METHODS: 439 consecutive patients with AF following catheter ablation were categorized as early recurrence (E) (3-6 months after ablation, 245 patients), late (L) ...
Weimar Timo - - 2012
BACKGROUND: Percutaneous catheter ablation has been the preferred treatment strategy for many patients with symptomatic drug-refractory atrial fibrillation (AF). However, incomplete ablation lines and varying success rates remain a problem in certain subgroups. This article evaluates the feasibility and efficacy of endoscopically performed left atrial ablation in patients with lone ...
Lopez-Olivo Maria A MA University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, - - 2012
Concerns exist regarding the potential development of malignancies in patients with rheumatoid arthritis (RA) who are receiving biologic response modifiers (BRMs). To assess the risk of malignancy in patients with RA enrolled in randomized controlled trials (RCTs) of BRMs. Electronic databases, conference proceedings, and websites of regulatory agencies were searched ...
Lee Min Ho - - 2012
Objective: To investigate the hepatoprotective effect, safety and tolerability of oral preparation comprising dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) plus garlic oil (GO) in chronic hepatitis patients. Methods: In this double-blind, placebo-controlled clinical trial conducted for 6 weeks with 1-week follow-up, a total of 88 patients with histologically confirmed chronic hepatitis and persistently ...
Räber Lorenz - - 2012
This study sought to assess stent strut coverage, malapposition, protrusion, and coronary evaginations as markers of healing 5 years after implantation of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES), by optical coherence tomography (OCT). Early-generation drug-eluting stents have been shown to delay vascular healing. A total of 88 event-free patients ...
Baudemont Céline - - 2012
Background: Behavioral and psychological symptoms of dementia (BPSD) are frequent and belong to the natural evolution of the disease. Specialized cognitive-behavioral units (Unités cognitivo-comportementales) were created, in France (plan Alzheimer 2008-2012), to cope with this problem. Despite a stay in such a unit, some patients have to be rehospitalized. The ...
Welle Mary Kay - - 2012
Patients who have major orthopaedic surgery are at high risk for developing venous thromboembolism (VTE). Assessment of risk and treatment to prevent VTE are considered standard of care due to its significant morbidity, potential mortality, and clinical burden and cost. Guidelines are available aiding orthopaedic surgeons to choose the best ...
Sim Yang-Won - - 2012
Chronic subdural hematoma (CSDH) is a typical disease that is encountered frequently in neurosurgical practice. The medications which could cause coagulopathies were known as one of the risk factors of CSDH, such as anticoagulants (ACs) and antiplatelet agents (APs). Recently, the number of patients who are treated with ACs/APs is ...
Garcia-Pagán J C - - 2012
BACKGROUND: In a recent randomized international clinical trial (RCT) in high-risk cirrhotic patients with acute variceal bleeding, the early use of transjugular intrahepatic portosystemic shunt (TIPS) was associated with marked and significant reductions both in treatment failure and in mortality. The aim of this study was to confirm these results ...
Neuner Elizabeth A - - 2012
Fosfomycin has shown promising in vitro activity against multidrug-resistant (MDR) urinary pathogens; however, clinical data are lacking. We conducted a retrospective chart review to describe the microbiological and clinical outcomes of urinary tract infections (UTIs) with MDR pathogens treated with fosfomycin tromethamine. Charts for 41 hospitalized patients with a urine ...
Weisz Giora - - 2012
BACKGROUND: The provisional approach for bifurcation stenting with side-branch balloon angioplasty is associated with dissections and suboptimal results requiring kissing balloon techniques or bailout stenting. We hypothesized that employing a scoring balloon for the side-branch and a drug-eluting stent for the main vessel might improve outcomes of true bifurcation lesions. ...
Seth Ashok A Escorts Heart Institute & Research Centre, New Delhi, - - 2012
Despite considerable benefits associated with current drug-eluting stents, continued attention to the safety, efficacy, and deliverability of available drug-eluting stent has led to the development of newer stent. This study was a single-centre, prospective, non-randomized, first-in-man study which included clinical follow-up data was collected at 1, 8 and 12 months ...
Abshire T C - - 2013
The bleeding patterns of severe von Willebrand's disease (VWD) adversely affect quality of life, and may be life threatening. There is a presumed role for prophylaxis with VWF-containing concentrates, but data are scarce. The von Willebrand Disease Prophylaxis Network (VWD PN) was formed to investigate the role of prophylaxis in ...
Manickam P - - 2012
We conducted randomized double-blind trial for single-dose of Rifampicin, Ofloxacin and Minocycline (ROM) compared to WHO-PB-MDT among paucibacillary (PB) leprosy patients with 2-5 skin lesions. We enrolled 1526 patients from five centres (ROM=762; WHO-PB-MDT=764) and followed them for 36 months posttreatment during 1998-2003. We generated information on clearance of skin ...
Arora Vikramjeet - - 2012
Narcotics have been used since long as a component of balanced anaesthesia, thus minimizing the anaesthetic requirement both during induction and maintenance as well as attenuating the pressor response during laryngoscopy and intubation. Equally significant is their role in provision of smoother recovery period by minimizing postoperative pain. Other than ...
Mansourian Afshin A Resident, Department of Anesthesiology, Kerman University of Medical Sciences, Kerman, - - 2012
Duration of spinal anesthesia depends on the type of anesthetic agent, dosage and additive materials such as epinephrine, ephedrine and opioid. We compared the duration of spinal anesthesia with lidocaine 5% with or without epinephrine in addict and non-addict patients undergoing inferior limb fracture surgery. This single blinded randomized clinical ...
Karimi-Mobarake Mahmood M Associate Professor, Department of Orthopedic Surgery, School of Medicine, Kerman University of Medical Sciences, Kerman, - - 2012
Osteonecrosis is common after taking Temgesic and Norgesic. This study intended to suggest the preferable surgical treatment in osteonecrosis patients who use these drugs. Twenty tree patients with hip osteonecrosis who were hospitalized in the Kerman hospitals after using Temgesic and Norgesic were followed for about 14 months from 2008 ...
Yang Hua - - 2012
Objective: This study was designed to investigate the relation between plasma von Willebrand factor (VWF) or endothelin-1 (ET-1) and post-carotid artery stenting (CAS) restenosis. Materials and Methods: Plasma levels of VWF and ET-1 were measured in 61 patients (36 males, mean age 64.4 ± 6.8 years) before and after CAS. ...
Salesi Mansour - - 2012
Patients with rheumatoid arthritis may be resistant to conventional treatment with disease-modifying antirheumatic drugs (DMARDs). On the other hand, biologic therapy is costly and may be inconvenient for many patients. Pamidronate is a potent bisphosphonate with the capacity of modifying the biological activity of the immune system cells. It may ...
Ruangsin Sakchai - - 2012
To evaluate the effectiveness of two-different doses of prophylactic dexamethasone intravenous administration in reducing the prevalence of postoperative sore throat following general endotracheal anesthesia. All patients (105 cases) of different procedures of elective surgery scheduled to have general anesthesia performed with endotracheal intubations were included. The subjects randomized into three ...
Fujii Shiro - - 2012
H(2) blockers have been reported to be responsible for drug-induced delirium. We compared the incidence of delirium between two groups of patients who were treated with H(2) blockers (H(2) group) or proton pump inhibitors (PPI group) for anastomotic ulcer prevention following surgical treatment of esophageal cancer. The incidence and severity ...
Rafiei Mohammad Reza - - 2012
The most common complications after tracheal intubation during general anesthesia are sore throat, hoarseness, and laryngospasm which can cause severe discomfort to patients. Several methods have been suggested to prevent these complications. In this study, the effects of intracuff dexamethasone, lidocaine, and normal saline in reducing post-extubation reactions were compared. ...
Faruqui Arif A - - 2012
Acute diarrhoea in adults is one of the most commonly encountered medical emergency in general practice and is responsible for considerable morbidity around the world. To evaluate the efficacy and tolerability of fixed dose combination of ofloxacin with ornidazole infusion (infusion O2) in the management of diarrhoea and dysentery, a ...
Kaan Nil - - 2012
The goal of this study is to investigate the incidence and risk factors of residual paralysis associated with single-dose intermediate-acting muscle relaxants (atracurium, vecuronium, rocuronium) during early postoperative period. Adult patients (ASA I and II) who received a single dose of vecuronium, atracurium or rocuronium during general anesthesia for elective ...
Abdulla Susanne - - 2012
In a randomized, double-blind trial, the synergistic action of intravenous parecoxib, metamizol or paracetamol on postoperative piritramide consumption was compared in patients recovering from total thyroidectomy during the first 24 h while evaluating pain intensity and patient satisfaction. 120 patients were randomly allocated to four patient groups treated with normal ...
Mehta Rupa R Department of Otorhinolaryngology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 - - 2013
Management of invasive fungal sinusitis includes both surgery and antifungal chemotherapy. To compare the efficacy of amphotericin B and itraconazole used alone in the management of chronic invasive fungal sinusitis. A prospective randomized unblinded study was conducted in the Department of Otolaryngology, Postgraduate Institute of Medical Education and Research, Chandigarh, ...
Ghazipour Ali A ENT Department, Ahvaz Jondi Shapour Medical University, Ahwaz, - - 2013
Clonidine is an antihypertensive drug which acts through facilitation of Alph-2 post-synaptic receptors and in addition to its antihypertensive, anti-anxiety and analgesic effects, its beneficial effects in reducing the bleeding during Neurosurgery and Orthopedics surgeries, delicate surgeries of ear and nasal and sinus endoscopy have been proved. In this study ...
Dua Naresh N Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi, 110060 - - 2014
The objective is to evaluate the prophylactic profile, efficacy of granisetron and ondansetron to prevent postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double blind trial, one hundred patients undergoing middle ear surgery received either granisetron 1 mg or ondansetron 8 mg in equal volume (n = 50 for each) ...
Otsuka Fumiyuki - - 2012
Several randomized and observational studies have reported steady increase in cumulative incidence of late and very late ST (LST/VLST) following first-generation drug-eluting stents (DES: sirolimus-(SES) and paclitaxel-(PES)) up to 5 years. Pathologic studies have identified uncovered struts as the primary substrate responsible for LST/VLST following DES, where delayed arterial healing ...
Jaya A R - - 2012
The purpose of this study is to evaluate and compare the clinical and radiographic effectiveness of Ciprofloxacin, Minocycline, Metronidazole combination with Ciprofloxacin, Minocycline and Tinidazole combination when used for Lesion Sterilization and Tissue Repair in primary teeth. 25 healthy children, visiting Dept. of Pediatric & Preventive Dentistry, D.A.P.M.R.V. Dental College, ...
Annandale D - - 2012
Three-drug regimens are routinely recommended in the UK for PEP after possible high-risk exposure to HIV. The current Department of Health and British Association for Sexual Health and HIV first-line regimen is lopinavir/ritonavir, tenofovir and emtricitabine (Truvada). Raltegravir-based regimens may be used as an alternative. This is a review of ...
Cozzi-Lepri A - - 2012
Atripla is a fixed-dose drug combining FTC/TDF/EFV into a single pill and may increase adherence. To our knowledge, there is little data comparing the durability of Atripla vs. other regimens. Our first aim was to compare the durability of Truvada (TVD)/EFV or TVD/PIr or Atripla started when ART-naïve, in terms ...
Rockstroh J - - 2012
Purpose of the study: The primary Week 48 analysis of this ongoing, randomized, double-blind, double-dummy, active-controlled Phase 3 international trial of elvitegravir/cobicistat/emtricitabine/tenofovir DF (Quad) in treatment-naïve patients demonstrated that Quad was non-inferior to atazanavir boosted by ritonavir (ATV/r) + FTC/TDF with a differentiated safety profile. We report the Week 96 ...
Dibajnia Parvin - - 2012
Ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. In psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms. The purpose of this study was to compare tear film stability between patients who use these drugs ...
Ataei Behrooz - - 2012
Introduction. The pathogenicity and transmission routes of Transfusion Transmitted Virus (TTV) remain unclear. The aim of this study was to determine the prevalence of TTV in hemodialysis patients, injecting drug users (IDUs), and healthy blood donors, in Isfahan, Iran. Method. In a case-control study, a total of 108 subjects were ...
Souvignet Julien - - 2012
Signal detection in pharmacovigilance should take into account all terms related to a medical concept rather than a single term. We built an OWL-DL file with formal definitions of MedDRA and SNOMED-CT concepts and performed two queries, Query 1 and 2, to retrieve narrow and broad terms within the Standard ...
Yang Caixia - - 2012
Drug-induced anesthesia combined with electroacupuncture (EA) in patients has been put into practice in recent years in China. In this study, we showed the effectiveness of EA on the speed of post-operative recovery of patients undergoing supratentorial craniotomy and the potential clinical mechanism of EA. Dual channel electrical stimulator made ...
Zolopa A - - 2012
Purpose of the study: The primary Week 48 analysis of this ongoing, randomized, double-blind, double-dummy, active-controlled Phase 3 trial of elvitegravir/cobicistat/emtricitabine/tenofovir DF (Quad) in treatment-naïve patients demonstrated that Quad was non-inferior to efavirenz/emtricitabine/tenofovir DF (EFV/FTC/TDF) with a differentiated safety profile. We report the Week 96 interim data. Methods: Key eligibility ...
Khan Subir Kumar - - 2012
The common nutritional deficiency, iron deficiency, causes Iron Deficiency Anemia (IDA) throughout the world especially in the developing countries. In Ayurveda, different herbal, mineral or herbomineral drugs have been emphasized to combat anemia (Panduroga). Trikatrayadi Lauha and Fersolate-CM (a modern medicine taken as standard control) were administered to the patients ...
Jabalameli Mitra - - 2012
Bupivacaine, tramadol, and pethidine has local anesthetic effect. The aim of this study was to compare effect of subcutaneous (SC) infiltration of tramadol, pethidine, and bupivacaine on postoperative pain relief after cesarean delivery. 120 patient, scheduled for elective cesarean section under spinal anesthesia, were randomly allocated to 1 of the ...
Junqueira Daniela R G - - 2012
Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction presenting as a prothrombotic disorder related to antibody-mediated platelet activation. It is a poorly understood paradoxical immune reaction resulting in thrombin generation in vivo, which leads to a hypercoagulable state and the potential to initiate venous or arterial thrombosis. A number of ...
Soleimanpour Hassan - - 2012
There are many drugs recommended for pain relief in patients with migraine headache. In a prospective double blind randomized clinical trial, 90 patients (age ≥ 18) presenting to Emergency medicine Department with Migraine headache were enrolled in two equal groups. We used intravenous propofol (10 mg every 5-10 minutes to a maximum ...
Kadic L - - 2012
Pain reduction is important for early mobilization after total knee arthroplasy. Recent studies show that local infiltration analgesia and addition of anti-hyperalgesic drugs (pregabalin and s-ketamine) may improve postoperative analgesia and mobilization. This pilot study was meant to evaluate if this new method of analgesia might improve patients' ability to ...
Amegbor K - - 2012
Vitex doniana is traditionally used in Togo to treat various diseases including wounds. The aim of this work was to evaluate the efficiency of Vitex doniana on cutaneous wound healing. Wounds were induced in ICR mice divided into four groups as following: Group I received carbopol 974P NF empty gel, ...
Gharibnaseri Zahra - - 2012
Intractable seizures are a subgroup of epileptic disorders challenging the physicians' skills to become controlled. Showing resistance towards common pharmacotherapy, they demand newer antiepileptic drugs acquired at higher costs. 0.06% of children around the world are estimated to suffer from epilepsy and its consequences. The aim of the present study ...
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