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Oldenburg J J Institute for Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, - - 2014
The development of alloantibody inhibitors against factor VIII (FVIII) represents the most significant complication of haemophilia care. Inhibitors tend to develop early in the course of treatment in about 20-30% of patients with severe haemophilia who receive on-demand or prophylactic FVIII therapy. Many factors are associated with inhibitor formation, including ...
Hong Sung Jin SJ Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, - - 2014
We sought to evaluate the clinical usefulness of decision making by a multidisciplinary heart team for identifying potential candidates for transcatheter aortic valve implantation (TAVI) in patients with symptomatic severe aortic stenosis. The multidisciplinary team consisted of two interventional cardiologists, two cardiovascular surgeons, one cardiac imaging specialist, and two cardiac ...
Furubayashi Nobuki N Department of Urology, National Kyushu Cancer Center, Fukuoka 811-1395, - - 2014
This study aimed to evaluate the usefulness of ultra-sensitive prostate-specific antigen (PSA) following radical prostatectomy (RP). Between September, 2003 and March, 2009, a total of 311 prostate cancer patients underwent antegrade RP; following the exclusion of 111 patients due to prior hormonal therapy, 200 patients were finally included in this ...
Soverow Jonathan J Division of Cardiology, UCLA Medical Center, 100 UCLA Medical Plaza, Los Angeles, CA, 90095, USA, - - 2014
Randomized, controlled clinical trials have shown significant benefits of statin therapy in patients with or at risk for atherosclerotic cardiovascular disease (ASCVD). But these trials typically enroll patients for only 5 years or so, prompting some clinicians to ask what the longer term follow-up of these patients will show. While most ...
Wronski Sofia S Sofia Wronski is a nurse practitioner in a trauma/surgical critical care advanced practice fellowship at the Hospital of the University of Pennsylvania in Philadelphia, - - 2014
Postoperative ileus (POI), a common postoperative complication, increases length of stay and costs. Although bowel rest and delayed oral intake were once thought to help prevent POI, newer evidence shows that chewing gum can be beneficial. The literature was searched for the terms ileus, gum, chewing, and gum chewing for ...
Kavros Steven J SJ Steven J. Kavros, DPM, is an Associate Professor of Podiatric Medicine, Mayo Clinic College of Medicine, and holds appointments in the Department of Orthopedic Surgery, Sections of Vascular Medicine, and Occupational, Preventitive, and Aerospace Medicine at the Mayo Clinic, Rochester, Minnesota. Timothy Dutra, DPM, is an Assistant Clinical Professor, Department of Applied Biomechanics and Clinical Investigator for the California School of Podiatric Medicine at Samuel Merritt University in Oakland, California. Renier Gonzalez-Cruz, MD, is Director of the Wound Care Clinic at the Hospital Metropolitano Dr Pila in Ponce, Puerto Rico; consulting physician at Casa del Veterano and San Cristobal Medical Center in Juana Diaz, Puerto Rico; and Attending Physician at the Hospital Dr Pila, Family Medicine Residency in Ponce, Puerto Rico. Brock Liden, DPM, is the owner of Reynoldsburg Podiatry Center LLC in Reynoldsburg, Ohio, and owner of Circleville Foot & Ankle LLC in Circleville, Ohio. Belinda Marcus, MD, is the Medical Director at HyperbaRXs in Cumming, Georgia. James McGuire, DPM, is an Associate Professor and Director of the Leonard Abrams Center for Advanced Wound Healing at the Temple University School of Podiatric Medicine in Philadelphia, Pennsylvania. Luis Nazario-Guirau, MD, is the Medical Director at the Auxilio Centro de Heridas y Medicina Hiperbarica in San Juan, Puerto Rico. Dr McGuire has disclosed that he is a consultant for Devon Medical, Zeomedix, TEI Biosciences, Healthpoint LTD, Steadmed Medical, BSN Medical, Medline Inc, Hollister, and Shire Dermagraft; and his institution received study grants from Diapedia LLC and Drexel - - 2014
The objective of this multicenter study was to prospectively evaluate the healing outcomes of chronic diabetic foot ulcers (DFUs) treated with PriMatrix (TEI Biosciences, Boston, Massachusetts), a fetal bovine acellular dermal matrix. Inclusion criteria required the subjects to have a chronic DFU that ranged in area from 1 to 20 ...
Turner Carole L - - 2014
Prevention of cerebral vasospasm is the target of modern drug therapy, candidates of which include statins. The results of phase 11 studies have shown promise in this arena. STASH is an international multicentre randomised controlled phase 111 trial designed to assess the effects of Simvastatin 40 mg on the long ...
Naves Juan E JE *Hospital Universitari Germans Trias i Pujol and Ciberehd, Badalona, Spain; †Universitat Autònoma de Barcelona, Barcelona, Spain; ‡Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; and §Hospital Universitari de Bellvitge and IDIBELL, L'Hospitalet de Llobregat, Barcelona, - - 2014
The short-term efficacy of infliximab (IFX) and cyclosporine A (CsA) in steroid-refractory ulcerative colitis (SRUC) has been recently shown to be similar, but long-term outcomes are still unclear. Moreover, the need for further rescue therapies in patients treated with IFX or CsA for SRUC has not been reported. The aims ...
El-Beshlawy Amal A Cairo University, Cairo, Egypt, - - 2014
Hydroxycarbamide (hydroxyurea or HU) has been shown to increase fetal hemoglobin (HbF) in patients with β-thalassemia intermedia (TI). The reported effects of HU in increasing the total hemoglobin (Hb) have been inconsistent. Studies of long-term therapy with HU in pediatric TI are rather uncommon. A retrospective observational study was carried ...
Maleux Geert G Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium, - - 2014
To retrospectively analyse the technical and clinical outcomes of embolotherapy for post-biliary sphincterotomy bleeding refractory to medical and endoscopic therapy, and in addition, to analyse factors potentially influencing 30-day mortality. From November 1998 to November 2012, 34 patients underwent percutaneous embolotherapy for post-biliary sphincterotomy bleeding refractory to medical and endoscopic ...
Esmat Gamal G 1 Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University , Cairo, Egypt - - 2014
The current standard of care therapy (SOC) for chronic HCV is pegylated interferon/ribavirin (Peg-IFN/RBV). Many reports showed the possible role of vitamin D supplementation in augmenting the response to SOC. The aim of this study was to assess the role of vitamin D supplementation on the response to treatment in ...
Gölz Leonie L Department of Neurosurgery, Unfallkrankenhaus Berlin, - - 2014
Object Shunt therapy in idiopathic normal pressure hydrocephalus (iNPH) can improve symptoms in 84% of patients 1 year postoperatively. Therefore, implantation of a ventriculoperitoneal shunt (VPS) prevents or at least prolongs the time during which patients are not dependent on care from others because of gait disorder or dementia. In ...
Hardesty Douglas A DA Divisions of Neurological Surgery - - 2014
Object Coccidioidomycosis is a common fungal infection in the southwestern US. Hydrocephalus is a serious complication of cranial coccidioidomycosis, and the surgical management of coccidioidomycosis-related hydrocephalus has unique challenges. The authors reviewed their institutional experience with hydrocephalus in the setting of coccidioidomycosis. Methods The authors retrospectively identified 44 patients diagnosed ...
Seward Christopher J CJ Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Neurosurgery, Gates Vascular Institute-Kaleida Health, Buffalo, New York, - - 2014
Experience with endovascular therapy of extracranial carotid artery pseudoaneurysm (ECAP) has been growing, and various results suggest it as a suitable treatment option. We present a consecutive case series of patients with ECAPs treated with endovascular therapy, and a pertinent literature review. A prospectively maintained database of neuroendovascular procedures was ...
Natali A A Department of Urology, Uro-Andrological Unit, University of Florence, Florence, - - 2014
We retrospectively analyzed the effects on the erectile function (EF) of no treatment (NT), and an oral therapy (OT; on-demand therapy (OD) or a regimented rehabilitation (RR) program with phosphodiesterase type 5 inhibitors (PDE5-Is)), in a cohort of 196 consecutive patients following nerve-sparing radical retropubic prostatectomy (NSRRP). Patients undergoing bilateral ...
Doycheva Deshka D Centre for Ophthalmology, University of Tuebingen, Tuebingen, - - 2014
To assess the long-term efficacy and tolerability of both derivatives of mycophenolic acid, mycophenolate mofetil (MMF) and mycophenolate sodium (MPS), in the therapy of patients with birdshot chorioretinopathy (BSCR). Retrospective analysis of 24 patients (48 eyes) with BSCR, treated with MMF or MPS with a follow-up of at least 1 year. ...
Sibbald Cathryn C Department of Dermatology, University of Toronto, Toronto, Ontario, - - 2014
Cyclosporine is a systemic therapy used for control of severe atopic dermatitis (AD) in children. Although traditionally recommended at a dose of 5 mg/kg/day for 6 months, a longer duration of treatment may be necessary to bring a child with active and severe disease into remission. There are few data on the ...
Mungo B B Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Neoadjuvant therapy has proven to be effective in the reduction of locoregional recurrence and mortality for esophageal cancer. However, induction treatment has been reported to be associated with increased risk of postoperative complications. We therefore compared outcomes after esophagectomy for esophageal cancer for patients who underwent neoadjuvant therapy and patients ...
Yoshikawa Norishige N Department of Pediatrics, Wakayama Medical University, Wakayama City, - - 2014
In this multicenter, open-label, randomized controlled trial, we determined whether 2-month prednisolone therapy for steroid-sensitive nephrotic syndrome was inferior or not to 6-month therapy despite significantly less steroid exposure. The primary end point was time from start of initial treatment to start of frequently relapsing nephrotic syndrome. The pre-specified non-inferiority ...
Dressler Dirk D Movement Disorders Section, Department of Neurology, Hannover Medical School, Hannover, Germany, - - 2014
We sought to explore the therapeutic effect of botulinum toxin (BT) therapy by analysing the time between the BT application and the onset of its decrease (treatment duration, TD), the inter-injection interval (II), and the excess time (ET, ET = II-TD). For this we studied 59 patients (37 females, 22 males, age ...
von Scheidt W W I.Medizinische Klinik, Herzzentrum Augsburg-Schwaben, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany, - - 2014
Limited data exist regarding baseline characteristics and management of heart failure with reduced ejection fraction (EF) in tertiary care facilities. EVITA-HF comprises web-based case report data on demography, comorbidities, diagnostic and therapy measures, quality of life, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ...
Li L L Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, USA - - - 2014
Dysphagia is not uncommon after stroke. Dysphagia may delay the functional recovery and substantially affects the quality of life after stroke, mainly if lest untreated. To detect and treat dysphagia as early as possible is critical for patients' recovery after stroke. Electrical stimulation has been reported as a treatment for ...
Yoshioka Daisuke D Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Japan, - - 2014
The aim of this study was to evaluate our clinical experience with the Jarvik 2000 axial flow pump (Jarvik Heart, Inc, New York, NY, USA), a miniature axial flow left ventricular assist device (LVAD). The clinical results of eight patients, who underwent LVAD implantation with the Jarvik 2000 (median age ...
Haegeli Laurent M LM Clinic for Cardiology, University Heart Center, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, - - 2014
Catheter ablation of atrial fibrillation (AF) is now an important therapeutic modality for patients with AF. There is considerable evidence available from several prospective randomized trials demonstrating that catheter ablation of AF is superior to antiarrhythmic drug therapy in controlling AF and that AF ablation improves quality of life substantially. ...
Jódar-Sánchez Francisco F Technological Innovation Group, Virgen del Rocío University Hospital, Seville, Spain Andalusian Public Foundation for Health Research Management in Seville, Seville, - - 2014
We conducted a cost-utility analysis of a telehealth programme for patients with severe chronic obstructive pulmonary disease (COPD) compared with usual care. A randomized controlled trial was carried out over four months with 45 patients treated with long-term oxygen therapy, 24 in the telehealth group (TG) and 21 in the ...
Matin Marzieh - - 2014
Abstract Objectives: Usage of 308-nm excimer laser (EL) is an effective treatment in vitiligo. As genetic predispositions along with type of skin and sun exposure rate are known factor influencing the treatment outcomes we tried to evaluate treatment results of using 308nm-excimer laser alone in comparison with combined therapy of ...
Huang Congwu C Department of Gastroenterology, the Second Affiliated Hospital of Shantou University , Shantou , - - 2014
Abstract Context: Proton pump inhibitor (PPI) increases the risk of decrease in bone mineral density (BMD). However, whether calcitrol improves this situation is unknown. Objective: The current study investigates the effects of calcitriol on BMD in patients with esomeprazole therapy. Materials and methods: Three hundred and eighty-six participants with gastrointestinal ...
Zhou YuQian Y Department of Gastroenterology, The 2nd Affiliated Hospital of XiangYa Medical School, Central South University , Changsha, Hunan, China - - 2014
Abstract Introduction: This study aimed to assess the safety and effectiveness of covered self-expanding metal stents for the treatment of nonvariceal esophageal bleeding in patients for whom routine therapies have failed. Patients and Methods: A retrospective analysis was conducted on patients with esophageal bleeding in our hospital. Data on hemostatic ...
Erdei Annamaria A Division of Endocrinology, Insitute of Medicine, University of Debrecen , Debrecen , Hungary - - 2014
Abstract The aim of this investigations was to study the effectiveness of anti-CD20 antibody therapy in Graves' orbitopathy (GO) resistant to glucocorticoids. Five patients were entered in the study. The protocol required no improvement of orbital status after a recent course of glucocorticoids. Activity of GO was confirmed by three ...
Papadopoulos N N Division of Thoracic and Cardiovascular Surgery, University Frankfurt/Main, Germany - - 2014
Risk factors for adverse outcome after extracorporeal life support (ECLS) are yet to be defined. For this purpose, we reviewed our institutional data from more than a decade, focusing on patients with ECLS. Between December 2001 and June 2013, 360 consecutive cardiac surgical patients received ECLS for post-cardiotomy cardiogenic shock, ...
Lavery Lawrence A LA Department of Plastic Surgery, University of Texas Southwestern, Dallas, TX, - - 2014
In a randomised, controlled study, we compared the efficacy of Grafix(®) , a human viable wound matrix (hVWM) (N = 50), to standard wound care (n = 47) to heal diabetic foot ulcers (DFUs). The primary endpoint was the proportion of patients with complete wound closure by 12 weeks. Secondary endpoints included the time to ...
Suzuki Tomoyuki T Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, 980-8574, - - 2014
Once a replaced prosthetic graft is infected, it is usually necessary to re-replace the thoracic aorta to achieve complete resolution of the infection. It is, however, an exceedingly invasive approach to perform such a repeat surgery on patients in a poor condition. We have managed both re-replacement of an infected ...
Silva Geisa Badauy Lauria GB Hematopoietic Stem Cell Transplant Unit, Araújo Jorge Hospital, Associação de Combate ao Câncer de Goiás, Goiânia, Goiás, - - 2014
Patients undergoing hematopoietic stem cell transplantation (HSCT) are submitted to a conditioning regimen of high-dose chemotherapy, with or without radiation therapy, which usually results in oral ulcerations and mucosal barrier breakdown. Oral mucositis (OM) is a common and debilitating toxicity side effect of autologous and allogeneic HSCT. The aim of ...
Molander Pauliina P Maria Helsinki City Hospital and University of Helsinki, Helsinki, Finland. Electronic address: - - 2014
This prospective multicenter study examined whether elevated fecal calprotectin (FC) concentrations after stopping TNFα-blocking therapy can predict clinical or endoscopic relapse. In addition, we evaluated the impact of histological remission on the relapse risk. We enrolled inflammatory bowel disease (IBD) patients who were in clinical, endoscopic, and FC-based (<100μg/g) remission ...
Busetto Gian Maria - - 2014
Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers the quality of life, (QoL) because not only is it a physical condition but also a ...
Samy Nevien A NA Dermatology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt, - - 2014
Photodynamic therapy (PDT) is regarded as a treatment option for basal cell carcinoma (BCC). The aim of this study is to investigate the efficacy of methylene blue (MB)-based PDT in patients suffering from nodular or ulcerative BCCs. This study is a prospective clinical trial with a 6-months follow-up. The study ...
Saka Yosuke Y Department of Internal Medicine, Kasugai Municipal Hospital, 1-1-1 Takakicho, Kasugai, 486-8510, Aichi, Japan, - - 2014
Catheter malposition is one of the reasons for outflow failure in peritoneal dialysis (PD) patients. Fluoroscopic manipulation is a non-surgical treatment option for catheter malposition. We retrospectively analyzed the efficacy and safety of fluoroscopic manipulation using an alpha-replacer guidewire. The alpha-replacer (JMS Co. Ltd., Tokyo, Japan) is a guidewire for ...
Ragaie Al-Helow M M Department of Physical Medicine & Rehabilitation, Ain Shams University, Egypt - - - 2014
Modified constraint induced movement therapy (m--CIMT) discourages the use of the unaffected extremity and encourages the active use of the hemiplegic arm in order to restore the motor function. To assess the efficacy of modified constraint induced movement therapy (m--CIMT) on functional recovery of upper extremity (UE) in acute stroke ...
Bech Anneke P AP Department of Nephrology, Radboud University Medical Centre, Nijmegen, The Netherlands; and - - 2014
The optimal timing and duration of immunosuppressive therapy for idiopathic membranous nephropathy (iMN) have been debated. This study aimed to evaluate whether measuring the antibody against the phospholipase A2 receptor (PLA2R-ab) at start and end of therapy predicts long-term outcome and therefore may inform this debate.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: ...
Nagappa M M Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka 560 029, - - 2014
Myasthenia gravis (MG) is a chronic autoimmune disorder with a fluctuating clinical course. The aim of immunotherapy is to bring about long-term remission. We evaluated the safety and efficacy of cyclophosphamide in generalized MG. We also highlight the limitations of cyclophosphamide therapy in inducing long-term remission. Data from 22 patients ...
Yaşar Zehra Aşuk ZA The Department of Sleep Disorders, Dr Suat Seren Chest Diseases and Surgery Training and Research Hospital, Yenisehir, 35110, Izmir, Turkey, - - 2014
Urinary albumin is a marker of cardiovascular morbidity and mortality, and also it has been viewed as a marker for vascular endothelial dysfunction in both the kidneys and systemic vasculature. Lowering urinary albumin is associated with fewer cardiovascular and renal diseases. We investigated the change in urinary albumin after 1 month ...
Moreira Amanda C AC Institute of Medicine and Dermatology (ISMD), São Paulo, SP, - - 2014
Facial aging is a natural biological process with symptoms such as sagging tissue, accentuated lines, furrows, wrinkles, dyschromias, and loss of facial volume. Rhytidectomy alone often fails to achieve a patient's expected goals, which is why there is a high demand for adjunct laser skin treatment. From January 2007 to ...
Sinha Aditi A Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, - - 2014
While studies show that prolonged initial prednisone therapy reduces the frequency of relapses in nephrotic syndrome, they lack power and have risk of bias. In order to examine the effect of prolonged therapy on frequency of relapses, we conducted a blinded, 1:1 randomized, placebo-controlled trial in 5 academic hospitals in ...
Higgins Peter Dr PD Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States. Electronic address: - - 2014
& Aims: We investigated whether treatment of active inflammatory bowel disease with biologic agents is associated with a reduced risk of venous thromboembolic events (VTEs), compared with corticosteroid therapy. We performed a retrospective analysis of 15,100 adults with inflammatory bowel disease, identified from the Truven Health MarketScan® databases. We analyzed ...
Takayama Hiroo H Department of Surgery, Columbia University Medical Center, New York, NY - - 2014
-Mortality for refractory cardiogenic shock (RCS) remains high. In this patient cohort there have been mixed results in mechanical circulatory support device use as a bridge-to-decision therapy. We evaluated a continuous-flow external ventricular assist device (VAD), CentriMag VAD (Thoratec Corp., Pleasanton, CA), in patients with various etiologies of RCS. -This ...
Kahrilas P J PJ Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, - - 2014
Little is known regarding patient characteristics that influence the speed of reflux oesophagitis (RO) healing. To investigate patient characteristics that may influence RO healing rates. A post hoc analysis of clinical trial data for potent acid suppression treatment of RO (esomeprazole or AZD0865) was conducted. Group A underwent endoscopy at ...
Okamura Kenichi K Department of Cardiovascular Surgery, Tsukuba Memorial Hospital. Electronic address: - - 2014
Spontaneous isolated dissection of the superior mesenteric artery (SIDSMA) is a rare and potentially fatal disease. Several therapeutic options are available, including conservative therapy, endovascular repair, and open surgery. Herein, we report our experiences in the treatment of SIDSMA. Between February 2009 and June 2013, 17 patients were diagnosed as ...
Ji Sang Gu SG Department of Physical Therapy, Eulji University Hospital, Daejeon, Republic of - - 2014
To investigate the effect of mirror therapy on the gait of patients with subacute stroke. Randomized controlled experimental study. Outpatient rehabilitation hospital. Thirty-four patients with stroke were randomly assigned to two groups: a mirror therapy group (experimental) and a control group. The stroke patients in the experimental group underwent comprehensive ...
Meyer Jacob C JC The Retina Institute, 1600 S. Brentwood Blvd., Suite 800, St. Louis, MO, 63144, USA, - - 2014
The optimal management approach to retinal arterial macroaneurysms (RAM) is unknown. This paper compares long-term outcomes in RAM treated with laser therapy versus observation. This is an IRB-approved retrospective study of patients with symptomatic RAM. Charts of patients with a diagnosis of RAM causing symptomatic visual loss were reviewed. Patients ...
Ma Jinlan J Department of Heallth Care, Qilu Hospital of Shandong University, Jinan, - - 2014
To evaluate the effect of photodynamic therapy (PDT) on central serous chorioretinopathy (CSC) compared with laser therapy and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs, and to find the maximum treatment effect with minimal dose and fluence of PDT. A systematic electronic search was conducted in Feb 2013 ...
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