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Mabuchi Tomotaka T Department of Dermatology, Tokai University School of Medicine, Kanagawa, - - 2014
Granulocyte monocyte apheresis (GMA) is an extracorporeal apheresis instrument that removes activated neutrophils and monocytes. Generalized pustular psoriasis (GPP) is characterized by neutrophil infiltration into the epidermis that causes Kogoj's spongiotic pustule. Thus, GMA is one of the useful therapies for GPP, and it was approved for the treatment in ...
Brambilla Anna Maria AM Emergency Medicine Department, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, - - 2014
The efficacy of noninvasive continuous positive airway pressure (CPAP) to improve outcomes in severe hypoxemic acute respiratory failure (hARF) due to pneumonia has not been clearly established. The aim of this study was to compare CPAP vs. oxygen therapy to reduce the risk of meeting criteria for endotracheal intubation (ETI). ...
Mayr Craig A CA Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery, University of Pittsburgh Medical Center, 513 Halket Street, Pittsburgh, PA 15213, - - 2014
Overactive bladder is a difficult to treat condition affecting a large proportion of adults resulting in considerable economic impact to society. First-line treatments such as behavioral therapy or antimuscarinic medication are frequently not effective in adequately controlling symptoms or have intolerable side effects. Patients subsequently require second-line therapy including, sacral ...
Ekman Bertil - - 2014
Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93-140/million), secondary AI (estimated prevalence, 150-280/million, respectively) or congenital adrenal hyperplasia (estimated prevalence, approximately 65/million) may be due to the inability of typical glucocorticoid treatment regimens to reproduce the normal circadian profile ...
Mani-Babu Sethu S Centre for Sports and Exercise Medicine, Queen Mary University of London, London, - - 2014
BACKGROUND:There is accumulating evidence for the effectiveness of extracorporeal shock wave therapy (ESWT) when treating lower limb tendinopathies including greater trochanteric pain syndrome (GTPS), patellar tendinopathy (PT), and Achilles tendinopathy (AT). PURPOSE:To evaluate the effectiveness of ESWT for lower limb tendinopathies. STUDY DESIGN:Systematic review and meta-analysis. METHODS:PubMed (Medline), Embase, Web ...
Goyal Mayank M Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada (M.G., M.A.A., B.K.M., A.M.D., M.D.H., M.E.); Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia (M.A.A.); Department of Public Health Sciences, Medical University of South Carolina, Charleston (L.F., S.D.Y.); Departments of Neurology and Radiology, University of Cincinnati, Cincinnati, OH (T.T., P.K., J.P.B.); Department of Radiology, Medical College of Wisconsin, Milwaukee (O.O.Z.); Division of Emergency Medicine, Medical University of South Carolina, Charleston (E.C.J.); and Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA (T.G.J.). - - 2014
Meaningful delays occurred in the Interventional Management of Stroke (IMS) III trial. Analysis of the work flow will identify factors contributing to the in-hospital delays. In the endovascular arm of the IMS III trial, the following time intervals were calculated: stroke onset to emergency department arrival; emergency department to computed ...
Thornby Krisy-Ann KA Palm Beach Atlantic University, West Palm Beach, FL, - - 2014
To review the literature evaluating the efficacy of dornase alfa for non-cystic fibrosis pediatric patients with pulmonary atelectasis. Articles were retrieved after a search of MEDLINE/PubMed (1946 to April 2014), and International Pharmaceutical Abstracts (1970-April 2014) was performed using the terms dornase alfa, recombinant human deoxyribonuclease, pulmonary, persistent, and atelectasis. ...
Vermeire Séverine S University of Leuven, Leuven, Belgium. Electronic address: - - 2014
Etrolizumab is a humanised monoclonal antibody that selectively binds the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed to assess etrolizumab in patients with moderately-to-severely active ulcerative colitis. In this double-blind, placebo-controlled, randomised, phase 2 study, patients with moderately-to-severely active ulcerative colitis who had not responded to ...
Schroeder U U ENT, University Hospital of Schleswig-Holstein, Luebeck, - - 2014
The therapy of complicated Kaposiform hemangioendothelioma (KHE) is still difficult. We present the first case of laryngomalacia with simultaneous mammalian target of Rapamycin (mTOR)-positive KHE of the neck and thoracic inlet and concurrent Kasabach-Meritt Phenomenon (KMP) in an 11-month-old boy suffering life-threatening progress despite intravenous vincristine, corticosteroids, propranolol and local ...
Torres Júnior Luiz Gonzaga LG Governador Israel Pinheiro Hospital, Belo Horizonte, Minas Gerais, Brazil, - - 2014
Curative treatment of upper gastrointestinal tract neoplasms is complex and associated with high morbidity and mortality. In general, the patients are already malnourished, and early postoperative enteral nutrition is recommended. However, there is no consensus concerning the best enteral access route in these cases. A prospective randomized trial was performed ...
De Vita Salvatore S Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital 'S. Maria della Misericordia' of Udine, Italy. - - 2014
The overexpression of B-cell activating factor (BAFF) in mucosa-associated lymphoid tissue (MALT) may decrease the efficacy of rituximab treatment in Sjögren's syndrome (SS). Anti-CD20 therapy was effective on marginal zone B cells, in the murine model for human CD20 expression only when preceded by anti-BAFF therapy. The possible efficacy of ...
Chaudhary Manu M 1Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, - - 2014
Background. Ethanol lock therapy (ELT) with systemic antimicrobial therapy (SAT) is a treatment for catheter-associated bloodstream infections (CABSI). However, its impact on hospital length of stay (LOS) is unknown. Objectives. Assess the impact of ELT on LOS, LOS attributable to CABSI (ALOS), and catheter salvage in pediatric hematology, oncology, stem ...
Ozcan Emin Evren EE Heart Center, Semmelweis University, Gaál József Street 9, Budapest, 1122, - - 2014
Radiofrequency (RF) catheter ablation guided by electroanatomic mapping systems is an effective therapy for atrial fibrillation. However, it may be affected by respiration movements. The aim of this study was to determine the impact of respiratory gating on procedural parameters in patients undergoing catheter ablation of atrial fibrillation (AF). One-hundred ...
Gifford Janet J Edward Hospital, Naperville, - - 2014
There are insufficient data to guide perioperative implantable cardioverter-defibrillator (ICD) management for patients undergoing surgical procedures using electrocautery. We conducted a multicenter randomized controlled trial of patients with ICDs undergoing surgery with monopolar electrocautery. Subjects were randomized to an "Off" group (ICD therapy programmed off, then postoperatively programmed on) or ...
Choi Jeong-Yoon JY From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., - - 2014
The objective of this study was to investigate the potential benefits of statin therapy on mortality and stroke recurrence after cardioembolic stroke. In this retrospective observational study, we analyzed data from 535 patients with first-ever cardioembolic stroke. Patients were classified into nonstatin, low-potency statin, and high-potency statin groups. The primary ...
Hillemanns Peter P Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, - - 2014
Non-surgical therapies are needed to reduce the rate of progression of low-grade cervical intraepithelial neoplasia (CIN 1) to high grade CIN (CIN 2/3). The aim of this study was to assess the efficacy and safety of hexaminolevulinate (HAL) photodynamic therapy (PDT) in the treatment of patients with CIN 1. This ...
Joseph Bellal B Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, University of Arizona, 1501 N. Campbell Avenue, Room 5411, P.O. Box 245063, Tucson, AZ, 85724, US, - - 2014
The development of coagulopathy of trauma is multifactorial associated with hypoperfusion and consumption of coagulation factors. Previous studies have compared the role of factor replacement versus FPP for reversal of trauma coagulopathy. The purpose of our study was to determine the time to correction of coagulopathy and blood product requirement ...
Hayakawa Kayoko K Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, - - 2014
Background:Vancomycin-resistant enterococci (VRE) are a growing health problem and uncertainties exist regarding the optimal therapy for bloodstream infection due to VRE. We conducted systematic comparative evaluations of the impact of different antimicrobial therapies on the outcomes of patients with bloodstream infections due to VRE.Methods:A retrospective study from 01/2008 to 10/2010 ...
Faria Inês I 1 Service of Pneumology, EPE North Lisbon Hospital Center , Pulido Valente Hospital, Lisbon, Portugal - - 2014
Abstract Background: Standard assessment of long-term oxygen therapy (LTOT) prescription involves hospital-based clinical tests. However, there is some evidence suggesting that oxygen demand during daily activities may not be correctly estimated by such tests, when compared with continuous ambulatory oximetry. The authors describe the results of a study aiming to ...
Yang Deng-Fu DF Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, - - 2014
Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT on hamster buccal pouch precancerous lesions. Twenty hamster buccal pouch precancerous lesions were treated with either ...
Arshad Aysha A Arrhythmia Institute, Valley Health System, New York, New York and Ridgewood, New - - 2014
There are a variety of periprocedural anticoagulation strategies for atrial fibrillation (AF) ablation, including the use of dabigatran. It is unclear which strategy is superior. To compare the safety and efficacy of anticoagulation with uninterrupted warfarin, dabigatran, and warfarin with heparin bridging in patients undergoing ablation of AF at four ...
Maggio Angelo A Medical Physics, San Raffaele Scientific Institute, Milan, Italy. Electronic address: - - 2014
To evaluate the efficacy of sodium butyrate enemas (NABUREN) in prostate cancer radiation therapy (RT) in reducing the incidence, severity, and duration of acute RT-induced proctitis. 166 patients, randomly allocated to 1 of 4 groups (rectal sodium butyrate 1 g, 2 g, or 4 g daily or placebo), were treated with NABUREN during ...
Yamamoto Kei K Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, - - 2014
The perioperative risk of non-cardiac surgery (NCS) in the patients on antiplatelet therapy after percutaneous coronary intervention (PCI) remains unclear. This study was a retrospective and single center study. Between January 2008 and December 2011, 198 patients who had already received PCI underwent NCS in our hospital. Among them, 63 ...
Otani Keisuke K Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, - - 2014
Radiation-induced organizing pneumonia (RIOP) is an important complication of postoperative radiotherapy for breast cancer. Unfortunately, conventional corticosteroid therapy is frequently associated with relapses. The aim of this retrospective study was to evaluate the outcomes of steroid treatment in patients with RIOP. In total, 26 patients diagnosed with RIOP from among ...
Kwak Min Seob - - 2014
The natural course of Crohn's disease (CD), with continuing relapses and remissions, leads to irreversible intestinal damage. Early adoption of immunomodulator therapy has been proposed in order to address this; however, it is still uncertain whether early immunomodulator therapy could affect the natural course of the disease in real practice. ...
El-Hayek Georges G Department of Cardiology, Mount Sinai St. Luke's Hospital, New York, New - - 2014
Current guidelines recommend 12 months of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation in the absence of increased bleeding risk. Studies have suggested that early discontinuation of DAPT can result in an increased risk of stent thrombosis. However, given the potential for major bleeding, the optimal duration of DAPT ...
Deharo P P Département de cardiologie, CHU Timone, 13385 Marseille, France; Inserm, UMR1062, « Nutrition, Obesity and Risk of Thrombosis », 13385 Marseille, France; Faculté de médecine, Aix-Marseille université, 13385 Marseille, France. Electronic address: - - 2014
Statin therapy is a cornerstone therapy for secondary prevention after acute coronary syndrome (ACS). However, the use of these drugs can be limited by side effects, mainly muscular pain. Ezetimibe is a newer lipid-lowering agent, with fewer side effects. The present study was designed to compare a commercially available association ...
Menetti Federico F Stroke Unit, Department of Neuroscience, "S. Agostino Estense" Hospital; Modena, Italy - - - 2014
The purpose of this study was to evaluate the efficacy and safety of intra-arterial therapy as a rescue strategy after clinically failed intravenous thrombolysis (IVT) in acute ischaemic stroke patients. We conducted a retrospective analysis of consecutive acute ischaemic stroke patients treated with rescue therapy. The results from this study ...
Falahatkar Siavash S Urology Research Center, Razi Hospital, Guilan University of Medical - - 2014
Objective: To compare the outcomes of bipolar transurethral vaporization of the prostate (TUVP) with bipolar transurethral resection of the prostate (TURP). Materials and Methods: In a prospective randomized trial, 88 patients with moderate to severe lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH) underwent bipolar TUVP (N = ...
Saglietti Giuseppe G Struttura Operativa Complessa di Diabetologia e Malattie Metaboliche, ASL VCO - Via Mazzini, 96, 28887, Omegna (VB), Italy, - - 2014
Diabetes mellitus is a complex, progressive disease that can lead to complications if it is not strictly controlled. The literature suggests that only 50 % of Italian patients with type 2 diabetes mellitus (T2DM) achieve guideline-recommended levels of glycaemic control, suggesting that treatment regimens need to be improved. The present study ...
Chuah Sai Yee SY Department of Dermatology, National Skin Centre, - - 2014
We reviewed the clinical characteristics and therapeutic response in cases of newly diagnosed bullous pemphigoid at the National Skin Centre between June 2009 and December 2010. Most (76%, n = 68/90) achieved clinical remission within 6 months of commencement of therapy. Oral mucosal involvement was identified as a risk factor associated with ...
Jin Chunlan C Chunlan Jin, MD, L.Ac., Attending physician, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, and Division of Gynecology, Hospital of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Dong Cheng District, Beijing, China. Xinyao Zhou, MD, Attending physician, Division of Internal Medicine, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Xi Cheng District, Beijing, China. Ran Pang, MD, Attending surgeon, Division of Urology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Xi Cheng District, Beijing, China, and Visiting scientist, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, - - 2014
To examine the effectiveness of combination therapy of electroacupuncture and tolterodine in treating female patients with mixed urinary incontinence. Seventy-one women with mixed urinary incontinence were recruited to receive electroacupuncture therapy or combination therapy with electroacupuncture and tolterodine 2 mg orally twice a day for 8 weeks. In electroacupuncture therapy, ...
Liberini P P Division of Neurology, Brescia General Hospital, Piazza Spedali Civili 1, Brescia, Italy, - - 2014
In 2013 the Italian Pharmacy Agency (AIFA) approved onabotulinumtoxin A injection to prevent headaches in adult patients with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine) that has not responded to at least three prior pharmacological prophylaxis therapies and whose condition ...
Marenzi Giancarlo G Centro Cardiologico Monzino, I.R.C.C.S., Milan, Italy. - - 2014
Background: There are limited data comparing ultrafiltration with standard medical therapy as first-line treatment in patients with severe congestive heart failure (HF). We compared ultrafiltration and conventional therapy in patients hospitalized for HF and overt fluid overload.Methods and Results: Fifty-six patients with congestive HF were randomized to receive standard medical ...
Kirchheiner Kathrin K Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna/General Hospital of Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria. Electronic address: - - 2014
Brachytherapy in the treatment of locally advanced cervical cancer has changed substantially because of the introduction of combined intracavitary/interstitial applicators and an adaptive target concept, which is the focus of the prospective, multi-institutional EMBRACE study (www.embracestudy.dk) on image-guided adaptive brachytherapy (IGABT). So far, little has been reported about the development ...
Ahmed Wasim W Department of Medicine, King Abdul Aziz Medical City, National Guard Health Affairs, Al Ahsa, Saudi - - 2014
Acute kidney injury (AKI) in the intensive care unit (ICU) is commonly caused by severe sepsis and septic shock. There is limited data regarding the incidence and outcomes of patients developing AKI treated with early goal-directed therapy (EGDT). Our aim was to observe the incidence and outcomes of patients with ...
Shaw Joshua J JJ 1 Department of Surgery, University of Massachusetts Medical School , Worcester, - - 2014
Abstract Background: The utility of hyperbaric oxygen therapy (HBOT) in the treatment of necrotizing soft tissue infections (NSTIs) has not been proved. Previous studies have been subject to substantial selection bias because HBOT is not available universally at all medical centers, and there is often considerable delay associated with its ...
Bron Morgan M Takeda Pharmaceuticals International, Inc., Deerfield, - - 2014
Current type 2 diabetes mellitus (T2DM) treatment involves progressive interventions from lifestyle changes to pharmacological therapies. Previous studies found that combination therapy with a dipeptidyl peptidase-4 inhibitor (DPP-4i) and pioglitazone (PIO) is more effective than monotherapies in treating poorly controlled T2DM, but there is no consensus on whether these drugs ...
Spear Scott L SL Washington, D.C. From the Department of Plastic Surgery, Georgetown University - - 2014
Although it is well established that reconstruction of the irradiated breast is associated with diminished cosmetic results and more frequent complications, little is known about the specific effects of radiation therapy on the reconstructive outcomes after nipple-sparing mastectomy. Patients who had nipple-sparing mastectomy and had either previous radiation therapy for ...
Chedid Victor V University of Pittsburgh Medical Center, Department of Internal Medicine, Pittsburgh, Pennsylvania (Dr Chedid), United - - 2014
Patients with small intestine bacterial overgrowth (SIBO) have chronic intestinal and extraintestinal symptomatology which adversely affects their quality of life. Present treatment of SIBO is limited to oral antibiotics with variable success. A growing number of patients are interested in using complementary and alternative therapies for their gastrointestinal health. The ...
Leal Nicole V NV Instituto Paraibano de Pesquisa, Campina Grande, Paraíba, - - 2014
The objective of this study was comparative use of magnesium sulfate for 12 compared with 24 hours in postpartum women with stable severe preeclampsia. An open, randomized clinical trial was conducted with 120 postpartum women with severe preeclampsia; 60 were allocated to receive magnesium sulfate for 24 hours and 60 ...
Akcan Alper A Department of General Surgery, Erciyes University School of Medicine, Kayseri, - - 2014
Idiopathic granulomatous mastitis (IGM) is an uncommon chronic inflammatory disease of the breast with uncertain optimal treatment regimen. In this study, our purpose was to report our clinical experience with 74 IGM patients who were treated wide local excision with or without steroid therapy. 74 cases diagnosed histologically as IGM ...
de Jong P H PH Department of Rheumatology, University Medical Center, Rotterdam, The - - 2014
To compare 1-year clinical efficacy of (1) initial triple disease-modifying antirheumatic drug therapy (iTDT) with initial methotrexate (MTX) monotherapy (iMM) and (2) different glucocorticoid (GC) bridging therapies: oral versus a single intramuscular injection in early rheumatoid arthritis. In a single-blinded randomised clinical trial patients were randomised into three arms: (A) ...
Sharifi Seyed Hossein Hosseini SH Shahid Labbafinejad Medical Center, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, I.R. - - 2014
Objective: To compare the safety and efficacy of combined therapy using sildenafil and tamsulosin for management of acute urinary retention (AUR) with tamsulosin alone in patients with benign prostate hyperplasia (BPH). Materials and Methods: 101 patients were enrolled in a randomized placebo-controlled study from June 2009 to April 2012. Patients ...
Nguyen Harrison P HP Baylor College of Medicine, Houston, - - 2014
Infantile hemangiomas (IH) are common benign vascular tumors seen in children. Although the majority will improve spontaneously without treatment, a small subset will require therapy due to a variety of complications. Less than a decade ago, propranolol replaced corticosteroids as first-line treatment for most IH and it has proven to ...
Abe Tatsuya T Department of Proctology, Kunimoto Hospital, Asahikawa, - - 2014
Aluminum potassium sulfate and tannic acid is a sclerosant used for sclerosing therapy in the treatment of hemorrhoids, and a Leeds-Keio artificial ligament is a new anal-encircling material for the management of rectal prolapse. The aim of this study was to evaluate clinical data and recurrence rates in patients with ...
Dee Brian B Brian Dee, Pharm.D., BCPS, BCNSP, is Clinical Pharmacy Specialist-Critical Care/Nutrition Support; Lindsey Lombardi Thomas, Pharm.D., BCOP, is Clinical Pharmacy Specialist-Stem Cell Transplantation; and Alison Gulbis, Pharm.D., BCOP, is Clinical Pharmacy Specialist-Stem Cell Transplantation, Division of Pharmacy, University of Texas MD Anderson Cancer Center, - - 2014
The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented. A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep ...
Leow O M - - 2014
This study aimed to evaluate the efficacy and safety of intra-articular glucocorticoid (IAG) injections in our institution in children with juvenile idiopathic arthritis (JIA). This is a retrospective assessment of IAG injections performed by the Department of Paediatrics, National University Hospital, Singapore, from October 2009 to October 2011. A total ...
Scarano Antonio A From the *Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy; †Department of Oral Rehabilitation, School of Dental Medicine, Tel-Aviv University, Israel; and ‡Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara, - - 2014
The aim of this study was to evaluate the use of calcium sulfate (CaS) as a hemostatic agent after tooth extraction in patients with anticoagulant drug therapy.A total of 30 patients undergoing anticoagulant therapy (22 women and 8 men) with a mean age of 54.6 years (SD = 9.2 years), ...
Gupta Aditya K - - 2014
Background:Topical therapies for onychomycosis are associated with less adverse events than systemic therapies, but poor nail penetration limits their efficacy. Consequently, an efinaconazole 10% nail solution was developed.Objective:To review the evidence supporting the usefulness of efinaconazole monotherapy in onychomycosis management.Methods:PubMed and clinicaltrials.gov databases and abstracts from the 2013 annual meeting ...
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