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Results 351 - 400 of 4750
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Ohrndorf S S Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, - - 2014
The objectives of this study are to evaluate a new semi-quantitative (0-5) musculoskeletal ultrasound (US) erosion score in patients with rheumatoid arthritis (RA) and to prove its usefulness in the detection of disease activity and success of therapy. Thirty-eight patients with RA (mean disease duration 10.1 ± 11.9 years) were enrolled. Start or ...
Kirchner Carmen C Department of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, - - 2014
Allogeneic blood products transfusion during liver transplantation (LT) can be associated with increased morbidity and mortality. Data on thromboelastometry (ROTEM)-guided coagulation management with coagulation factor concentrates (CFCs)-fibrinogen concentrate and/or prothrombin complex concentrate (PCC)-are sparse. We aimed to retrospectively evaluate the safety events observed with this approach in our clinic. LT ...
Gulati Sheffali S Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Electronic address: - - 2014
Neurocysticercosis, parasitic infestation of the central nervous system by the Taenia solium larvae, is a major public health problem, primarily in the developing countries. Seizures are the primary clinical manifestation which could be acute (secondary to active lesions) or remote symptomatic (due to calcified lesions). Cysticidal therapy is the standard ...
Hoshino Taro T Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama, 330-8503, - - 2014
Type 2 diabetic kidney disease (DKD) is frequently accompanied by uncontrollable hypertension due to the sodium sensitivity inherent in DKD and to diuretic-resistant edema. In general, diuretics are effective in treating this condition, but thiazide diuretics are thought to be innocuous in advanced chronic kidney disease (CKD). We examined the ...
Hogan Maurice M Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK - - 2014
Anaemia is common in patients with cardiac disease and also in those undergoing cardiac surgery. There is increasing evidence that preoperative anaemia is associated with increased patient morbidity and mortality following surgery. We performed a systematic literature review to assess the impact of anaemia and intravenous (IV) iron supplementation on ...
Riccio Lin M LM Department of Surgery, University of Virginia Health System , Charlottesville, - - 2014
Abstract Background: We hypothesized that a longer duration of antibiotic treatment for intra-abdominal infections (IAI) would be associated with an increased risk of extra-abdominal infections (EAI) and high mortality. Methods: We reviewed all IAI occurring in a single institution between 1997 and 2010. The IAI were divided into two groups ...
Zhang Xiongliang X Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, - - 2014
Endothelial progenitor cells (EPCs) have been used to revascularize ischemic tissues, but only limited effect can be achieved. Extracorporeal shock-wave therapy (ESWT) is a promising angiogenic strategy. We hypothesized that EPC transplantation combined with ESWT would greatly benefit the survival of ischemic skin flaps. Sixty-four male Sprague-Dawley rats were divided ...
Suzuki Makoto M Department of Cardiology, Kameda Medical Center, Chiba, - - 2014
Severe chronic kidney disease (CKD) is a risk factor for hemorrhagic events in atrial fibrillation (AF) patients on anticoagulation therapy. We postulated that even moderate CKD may be a risk factor for hemorrhage and this recognition would improve predictive capabilities of hemorrhagic risk stratification models in Japanese patients. In this ...
Elbaz Avi A AposTherapy Research Group, Herzliya 46733, - - 2014
To investigate the effect of a biomechanical therapy on gait, function and clinical condition in patients following total knee arthroplasty (TKA). Seventeen TKA patients participated in the study. Patients received a biomechanical therapy AposTherapy). Patients underwent a gait test, clinical examination and an assessment of pain, function and quality of ...
Chen Ling L Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, - - 2014
To evaluate safety and visual outcomes after proton beam irradiation (PBI) therapy for subfoveal choroidal neovascularisation (CNV) secondary to causes other than age-related macular degeneration (AMD). This study is a prospective, unmasked and randomised clinical trial using two dosage regimens, conducted in the Massachusetts Eye and Ear Infirmary. The study ...
Ter Wee Marieke M MM Department of Rheumatology, VU University Medical Center, Amsterdam, Noord Holland, The - - 2014
Recently, we documented the likely non-inferiority of Combinatietherapie Bij Reumatoïde Artritis (COBRA)-light therapy (methotrexate increased to 25 mg/week with initial prednisolone 30 mg/day) compared with the original COBRA therapy (methotrexate 7.5 mg/week, sulfasalazine 2 g/day, with initial prednisolone 60 mg/day) after 26 weeks in patients with early active rheumatoid arthritis ...
Beck Vance - - 2014
Despite recent advances in the management of septic shock, mortality remains unacceptably high. Earlier initiation of key therapies including appropriate antimicrobials and fluid resuscitation appears to reduce the mortality in this condition. This study examined whether early initiation of vasopressor therapy is associated with improved survival in fluid therapy-refractory septic ...
Johnson Sally S Great North Children's Hospital, Newcastle Upon Tyne, UK, - - 2014
In 2009, the European Paediatric Study Group for Haemolytic Uraemic Syndrome (HUS) published a clinical practice guideline for the investigation and initial therapy of diarrhea-negative HUS (now more widely referred to as atypical HUS, aHUS). The therapeutic component of the guideline (comprising early, high-volume plasmapheresis) was derived from anecdotal evidence ...
Brambilla Anna Maria AM Emergency Medicine Department, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, - - 2014
The efficacy of noninvasive continuous positive airway pressure (CPAP) to improve outcomes in severe hypoxemic acute respiratory failure (hARF) due to pneumonia has not been clearly established. The aim of this study was to compare CPAP vs. oxygen therapy to reduce the risk of meeting criteria for endotracheal intubation (ETI). ...
Mabuchi Tomotaka T Department of Dermatology, Tokai University School of Medicine, Kanagawa, - - 2014
Granulocyte monocyte apheresis (GMA) is an extracorporeal apheresis instrument that removes activated neutrophils and monocytes. Generalized pustular psoriasis (GPP) is characterized by neutrophil infiltration into the epidermis that causes Kogoj's spongiotic pustule. Thus, GMA is one of the useful therapies for GPP, and it was approved for the treatment in ...
Mayr Craig A CA Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery, University of Pittsburgh Medical Center, 513 Halket Street, Pittsburgh, PA 15213, - - 2014
Overactive bladder is a difficult to treat condition affecting a large proportion of adults resulting in considerable economic impact to society. First-line treatments such as behavioral therapy or antimuscarinic medication are frequently not effective in adequately controlling symptoms or have intolerable side effects. Patients subsequently require second-line therapy including, sacral ...
Goyal Mayank M Hotchkiss Brain Institute, University of Calgary, Calgary, AB, - - 2014
Meaningful delays occurred in the IMS III trial. Analysis of the workflow will identify factors contributing to the in-hospital delays. In the endovascular arm of the IMS III trial, these time intervals were calculated: stroke onset to ED arrival; ED to CT; CT to IV tPA start; IV tPA start ...
Mani-Babu Sethu S Centre for Sports and Exercise Medicine, Queen Mary University of London, London, - - 2014
BACKGROUND:There is accumulating evidence for the effectiveness of extracorporeal shock wave therapy (ESWT) when treating lower limb tendinopathies including greater trochanteric pain syndrome (GTPS), patellar tendinopathy (PT), and Achilles tendinopathy (AT). PURPOSE:To evaluate the effectiveness of ESWT for lower limb tendinopathies. STUDY DESIGN:Systematic review and meta-analysis. METHODS:PubMed (Medline), Embase, Web ...
Ekman Bertil - - 2014
Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93-140/million), secondary AI (estimated prevalence, 150-280/million, respectively) or congenital adrenal hyperplasia (estimated prevalence, approximately 65/million) may be due to the inability of typical glucocorticoid treatment regimens to reproduce the normal circadian profile ...
Thornby Krisy-Ann KA Palm Beach Atlantic University, West Palm Beach, FL, - - 2014
To review the literature evaluating the efficacy of dornase alfa for non-cystic fibrosis pediatric patients with pulmonary atelectasis. Articles were retrieved after a search of MEDLINE/PubMed (1946 to April 2014), and International Pharmaceutical Abstracts (1970-April 2014) was performed using the terms dornase alfa, recombinant human deoxyribonuclease, pulmonary, persistent, and atelectasis. ...
Torres Júnior Luiz Gonzaga LG Governador Israel Pinheiro Hospital, Belo Horizonte, Minas Gerais, Brazil, - - 2014
Curative treatment of upper gastrointestinal tract neoplasms is complex and associated with high morbidity and mortality. In general, the patients are already malnourished, and early postoperative enteral nutrition is recommended. However, there is no consensus concerning the best enteral access route in these cases. A prospective randomized trial was performed ...
Schroeder U U ENT, University Hospital of Schleswig-Holstein, Luebeck, - - 2014
The therapy of complicated Kaposiform hemangioendothelioma (KHE) is still difficult. We present the first case of laryngomalacia with simultaneous mammalian target of Rapamycin (mTOR)-positive KHE of the neck and thoracic inlet and concurrent Kasabach-Meritt Phenomenon (KMP) in an 11-month-old boy suffering life-threatening progress despite intravenous vincristine, corticosteroids, propranolol and local ...
Vermeire Séverine S University of Leuven, Leuven, Belgium. Electronic address: - - 2014
Etrolizumab is a humanised monoclonal antibody that selectively binds the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed to assess etrolizumab in patients with moderately-to-severely active ulcerative colitis. In this double-blind, placebo-controlled, randomised, phase 2 study, patients with moderately-to-severely active ulcerative colitis who had not responded to ...
De Vita Salvatore S Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital 'S. Maria della Misericordia' of Udine, Italy. - - 2014
The overexpression of B-cell activating factor (BAFF) in mucosa-associated lymphoid tissue (MALT) may decrease the efficacy of rituximab treatment in Sjögren's syndrome (SS). Anti-CD20 therapy was effective on marginal zone B cells, in the murine model for human CD20 expression only when preceded by anti-BAFF therapy. The possible efficacy of ...
Ozcan Emin Evren EE Heart Center, Semmelweis University, Gaál József Street 9, Budapest, 1122, - - 2014
Radiofrequency (RF) catheter ablation guided by electroanatomic mapping systems is an effective therapy for atrial fibrillation. However, it may be affected by respiration movements. The aim of this study was to determine the impact of respiratory gating on procedural parameters in patients undergoing catheter ablation of atrial fibrillation (AF). One-hundred ...
Gifford Janet J Edward Hospital, Naperville, - - 2014
There are insufficient data to guide perioperative implantable cardioverter-defibrillator (ICD) management for patients undergoing surgical procedures using electrocautery. We conducted a multicenter randomized controlled trial of patients with ICDs undergoing surgery with monopolar electrocautery. Subjects were randomized to an "Off" group (ICD therapy programmed off, then postoperatively programmed on) or ...
Chaudhary Manu M 1Wayne State University School of Medicine; Children's Hospital of Michigan, Detroit, MI, - - 2014
Background. Ethanol lock therapy (ELT) with systemic antimicrobial therapy (SAT) is a treatment for catheter-associated bloodstream infections (CABSI). However, its impact on hospital length of stay (LOS) is unknown. Objectives. Assess the impact of ELT on LOS, LOS attributable to CABSI (ALOS), and catheter salvage in pediatric hematology, oncology, stem ...
Joseph Bellal B Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, University of Arizona, 1501 N. Campbell Avenue, Room 5411, P.O. Box 245063, Tucson, AZ, 85724, US, - - 2014
The development of coagulopathy of trauma is multifactorial associated with hypoperfusion and consumption of coagulation factors. Previous studies have compared the role of factor replacement versus FPP for reversal of trauma coagulopathy. The purpose of our study was to determine the time to correction of coagulopathy and blood product requirement ...
Hillemanns Peter P Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, - - 2014
Non-surgical therapies are needed to reduce the rate of progression of low-grade cervical intraepithelial neoplasia (CIN 1) to high grade CIN (CIN 2/3). The aim of this study was to assess the efficacy and safety of hexaminolevulinate (HAL) photodynamic therapy (PDT) in the treatment of patients with CIN 1. This ...
Choi Jeong-Yoon JY From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., - - 2014
The objective of this study was to investigate the potential benefits of statin therapy on mortality and stroke recurrence after cardioembolic stroke. In this retrospective observational study, we analyzed data from 535 patients with first-ever cardioembolic stroke. Patients were classified into nonstatin, low-potency statin, and high-potency statin groups. The primary ...
Faria Inês I 1 Service of Pneumology, EPE North Lisbon Hospital Center , Pulido Valente Hospital, Lisbon, Portugal - - 2014
Abstract Background: Standard assessment of long-term oxygen therapy (LTOT) prescription involves hospital-based clinical tests. However, there is some evidence suggesting that oxygen demand during daily activities may not be correctly estimated by such tests, when compared with continuous ambulatory oximetry. The authors describe the results of a study aiming to ...
Hayakawa Kayoko K Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, - - 2014
Background:Vancomycin-resistant enterococci (VRE) are a growing health problem and uncertainties exist regarding the optimal therapy for bloodstream infection due to VRE. We conducted systematic comparative evaluations of the impact of different antimicrobial therapies on the outcomes of patients with bloodstream infections due to VRE.Methods:A retrospective study from 01/2008 to 10/2010 ...
Yang Deng-Fu DF Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, - - 2014
Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT on hamster buccal pouch precancerous lesions. Twenty hamster buccal pouch precancerous lesions were treated with either ...
Arshad Aysha A Arrhythmia Institute, Valley Health System, New York, New York and Ridgewood, New - - 2014
There are a variety of periprocedural anticoagulation strategies for atrial fibrillation (AF) ablation, including the use of dabigatran. It is unclear which strategy is superior. To compare the safety and efficacy of anticoagulation with uninterrupted warfarin, dabigatran, and warfarin with heparin bridging in patients undergoing ablation of AF at four ...
Otani Keisuke K Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, - - 2014
Radiation-induced organizing pneumonia (RIOP) is an important complication of postoperative radiotherapy for breast cancer. Unfortunately, conventional corticosteroid therapy is frequently associated with relapses. The aim of this retrospective study was to evaluate the outcomes of steroid treatment in patients with RIOP. In total, 26 patients diagnosed with RIOP from among ...
Yamamoto Kei K Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, - - 2014
The perioperative risk of non-cardiac surgery (NCS) in the patients on antiplatelet therapy after percutaneous coronary intervention (PCI) remains unclear. This study was a retrospective and single center study. Between January 2008 and December 2011, 198 patients who had already received PCI underwent NCS in our hospital. Among them, 63 ...
Maggio Angelo A Medical Physics, San Raffaele Scientific Institute, Milan, Italy. Electronic address: - - 2014
To evaluate the efficacy of sodium butyrate enemas (NABUREN) in prostate cancer radiation therapy (RT) in reducing the incidence, severity, and duration of acute RT-induced proctitis. 166 patients, randomly allocated to 1 of 4 groups (rectal sodium butyrate 1 g, 2 g, or 4 g daily or placebo), were treated with NABUREN during ...
Kwak Min Seob - - 2014
The natural course of Crohn's disease (CD), with continuing relapses and remissions, leads to irreversible intestinal damage. Early adoption of immunomodulator therapy has been proposed in order to address this; however, it is still uncertain whether early immunomodulator therapy could affect the natural course of the disease in real practice. ...
El-Hayek Georges G Department of Cardiology, Mount Sinai St. Luke's Hospital, New York, New - - 2014
Current guidelines recommend 12 months of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation in the absence of increased bleeding risk. Studies have suggested that early discontinuation of DAPT can result in an increased risk of stent thrombosis. However, given the potential for major bleeding, the optimal duration of DAPT ...
Deharo P P Département de cardiologie, CHU Timone, 13385 Marseille, France; Inserm, UMR1062, « Nutrition, Obesity and Risk of Thrombosis », 13385 Marseille, France; Faculté de médecine, Aix-Marseille université, 13385 Marseille, France. Electronic address: - - 2014
Statin therapy is a cornerstone therapy for secondary prevention after acute coronary syndrome (ACS). However, the use of these drugs can be limited by side effects, mainly muscular pain. Ezetimibe is a newer lipid-lowering agent, with fewer side effects. The present study was designed to compare a commercially available association ...
Chuah Sai Yee SY Department of Dermatology, National Skin Centre, - - 2014
We reviewed the clinical characteristics and therapeutic response in cases of newly diagnosed bullous pemphigoid at the National Skin Centre between June 2009 and December 2010. Most (76%, n = 68/90) achieved clinical remission within 6 months of commencement of therapy. Oral mucosal involvement was identified as a risk factor associated with ...
Kirchheiner Kathrin K Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna/General Hospital of Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria. Electronic address: - - 2014
Brachytherapy in the treatment of locally advanced cervical cancer has changed substantially because of the introduction of combined intracavitary/interstitial applicators and an adaptive target concept, which is the focus of the prospective, multi-institutional EMBRACE study (www.embracestudy.dk) on image-guided adaptive brachytherapy (IGABT). So far, little has been reported about the development ...
Dee Brian B Brian Dee, Pharm.D., BCPS, BCNSP, is Clinical Pharmacy Specialist-Critical Care/Nutrition Support; Lindsey Lombardi Thomas, Pharm.D., BCOP, is Clinical Pharmacy Specialist-Stem Cell Transplantation; and Alison Gulbis, Pharm.D., BCOP, is Clinical Pharmacy Specialist-Stem Cell Transplantation, Division of Pharmacy, University of Texas MD Anderson Cancer Center, - - 2014
The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented. A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep ...
Leal Nicole V NV Instituto Paraibano de Pesquisa, Campina Grande, Paraíba, - - 2014
The objective of this study was comparative use of magnesium sulfate for 12 compared with 24 hours in postpartum women with stable severe preeclampsia. An open, randomized clinical trial was conducted with 120 postpartum women with severe preeclampsia; 60 were allocated to receive magnesium sulfate for 24 hours and 60 ...
Spear Scott L SL Washington, D.C. From the Department of Plastic Surgery, Georgetown University - - 2014
Although it is well established that reconstruction of the irradiated breast is associated with diminished cosmetic results and more frequent complications, little is known about the specific effects of radiation therapy on the reconstructive outcomes after nipple-sparing mastectomy. Patients who had nipple-sparing mastectomy and had either previous radiation therapy for ...
Saglietti Giuseppe G Struttura Operativa Complessa di Diabetologia e Malattie Metaboliche, ASL VCO - Via Mazzini, 96, 28887, Omegna (VB), Italy, - - 2014
Diabetes mellitus is a complex, progressive disease that can lead to complications if it is not strictly controlled. The literature suggests that only 50 % of Italian patients with type 2 diabetes mellitus (T2DM) achieve guideline-recommended levels of glycaemic control, suggesting that treatment regimens need to be improved. The present study ...
Shaw Joshua J JJ 1 Department of Surgery, University of Massachusetts Medical School , Worcester, - - 2014
Abstract Background: The utility of hyperbaric oxygen therapy (HBOT) in the treatment of necrotizing soft tissue infections (NSTIs) has not been proved. Previous studies have been subject to substantial selection bias because HBOT is not available universally at all medical centers, and there is often considerable delay associated with its ...
Jones Douglas W DW Vascular and Endovascular Surgery, New York Presbyterian Hospital - Weill-Cornell Medical Center, New York, NY, - - 2014
After endovascular therapy, duplex ultrasound surveillance to detect restenosis guides clinical decisions and defines treatment failure. However, the correlation between duplex ultrasound and symptom recurrence remains unclear. We reviewed our institutional experience (2007-2010) to identify patients undergoing endovascular therapy for claudication. The association between post-intervention systolic velocity ratio and patient-reported ...
Kahloon Arslan A Department of Internal Medicine, University of Tennessee College of Medicine, Chattanooga, 979 East Third Street, Suite C-825, Chattanooga, TN, 37403, USA, - - 2014
Gastric variceal bleeding is associated with significant morbidity and mortality and limited endoscopic therapeutic options. The aim of this study was to evaluate the short- and long-term efficacy and safety of endoscopic therapy with 2-octyl-cyanoacrylate in patients with gastric variceal bleeding. A single-center retrospective review of patients receiving endoscopic therapy ...
Nammas Wail W Heart Center, Turku University Hospital and University of Turku , Turku , - - 2014
Abstract Background. The FinPAC trial showed that the strategy of uninterrupted oral anticoagulation (OAC) was non-inferior to interrupted OAC for the primary outcome of bleeding and thromboembolic complications in patients undergoing cardiac rhythm management device (CRMD) implantation. Methods. We conducted a post hoc analysis of the FinPAC data to explore ...
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