Search Results
Results 301 - 350 of 4163
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Regueiro Miguel M Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center. Electronic address: - - 2014
A previous randomized, placebo-controlled study showed that infliximab maintenance therapy prevented recurrence of Crohn's disease 1 year after an ileo-colonic resection. We evaluated recurrence of Crohn's disease, based on endoscopic examination and/or the need for additional surgical resection, beyond the first postoperative year. In a prospective, open-label, long-term follow-up study, ...
Cocero Nadia N Resident, Oral Surgery Section, Dental School of the University of Torino, Azienda Ospedaliera Città della Salute e della Scienza, Torino, Italy. Electronic address: - - 2014
Oral anticoagulant therapy (OAT) patients have international normalized ratio (INR) safety windows for oral surgery, the lower limit of which is determined by the thromboembolic risk, with the upper limit typically 3.0. We sought to assess whether these limits will also be true with comorbidities that favor bleeding, such as ...
Morici Nuccia N Divisione di Cardiologia 1-Emodinamica, Dipartimento Cardio-toraco-vascolare "A. De Gasperis", Azienda Ospedaliera Ospedale Niguarda Cà Granda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy, - - 2014
Patients needing surgery within 1 year after drug-eluting cardiac stent implantation are challenging to manage because of an increased thrombotic and bleeding risk. A "bridge therapy" with short-acting antiplatelet agents in the perioperative period is an option. We assessed the outcome and safety of such a bridge therapy in cardiovascular and ...
Takeda Toshikazu T Department of Urology, Keio University School of Medicine, Tokyo, - - 2014
The aim of this study was to investigate if neoadjuvant hormone therapy (NHT) is associated with surgical outcomes of laparoscopic radical prostatectomy. A total of 286 patients with organ-confined prostate cancer and a preoperative prostate volume that could be estimated by transrectal ultrasound underwent laparoscopic radical prostatectomy between 2006 and ...
Oleen-Burkey Merrikay - - 2014
Long-term persistence to treatment for chronic disease is difficult for patients to achieve, regardless of the disease or medication being used. The objective of this investigation was to examine treatment persistence with glatiramer acetate (GA) relative to available disease-modifying therapies (DMT) for multiple sclerosis (MS) over 12-, 24- and 36-month ...
Inokuchi Toshihiro T Toshihiro Inokuchi, Sakiko Hiraoka, Hideyuki Suzuki, Asuka Nakarai, Tomoko Hirakawa, Mitsuhiro Akita, Sakuma Takahashi, Keita Harada, Hiroyuki Okada, Kazuhide Yamamoto, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, - - 2014
To clarify the impact of cytomegalovirus (CMV) activation and antiviral therapy based on CMV antigen status on the long-term clinical course of ulcerative colitis (UC) patients. UC patients with flare-up were divided into CMV-positive and -negative groups according to the CMV antigenemia assay. The main treatment strategy provided for the ...
Fiedler K Anette KA Deutsches Herzzentrum, Technische Universität, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Electronic address: - - 2014
An increasing number of patients undergoing coronary stenting need lifelong anticoagulation and therefore require a triple therapy typically consisting of aspirin, clopidogrel, and a vitamin K antagonist. Triple therapy confers an elevated bleeding risk as compared with dual therapy; however, omission of either antiplatelet or anticoagulation therapy might increase the ...
Caffrey Aisling R AR Infectious Diseases Research Program, Veterans Affairs Medical Center, Providence, Rhode Island; Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston, Rhode - - 2014
As variability in vancomycin dosing, susceptibility, and tolerability has driven the need to compare newer agents with vancomycin in real-world clinical settings, we sought to quantify the effectiveness of linezolid compared with vancomycin on clinical outcomes for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Retrospective cohort study. Veterans Health ...
Manigandan J Bala JB Swami Vivekanand National Institute of Rehabilitation Training & Research, Cuttack Dt, Odisha, - - 2014
Glenohumeral subluxation is the most frequent complication in post stroke hemiplegia and its reduction has been considered an important goal. Though it has been demonstrated that cyclical electrical stimulation of posterior deltoid and supraspinatus muscles can reduce subluxation, the role biceps has not been given due consideration. The purpose of ...
Valentino L A LA Rush University Medical Center, Chicago, IL, - - 2014
Few randomized studies have reported on the use of factor IX (FIX) for secondary prophylaxis in haemophilia B patients. This study aimed to evaluate the efficacy and safety of two secondary prophylaxis regimens of recombinant coagulation FIX, nonacog alfa, compared with on-demand therapy. Male subjects aged 6-65 years with severe or ...
Joshi Lavnish L Moorfields Eye Hospital, London, United Kingdom; UCL Institute of Ophthalmology, London, United - - 2014
To evaluate the outcomes of changing immunosuppressive therapy for noninfectious uveitis after failure. Retrospective cohort study. Patients with noninfectious uveitis managed at 2 tertiary uveitis clinics in the United Kingdom and Australia. Participants with a history of using immunosuppressive therapy were identified in clinics, and notes were reviewed by doctors ...
Karimi Ashkan A Department of Medicine, University of Florida, Gainesville, FL, - - 2014
Bleeding is the most common complication of HeartMate II and is partially attributable to platelet dysfunction; however, antiplatelet therapy is arbitrary in most centres. We investigated how antiplatelet therapy adjustment with thrombelastography affects late-onset bleeding. Thrombelastography was used to adjust antiplatelet therapy in 57 HeartMate II recipients. Kaplan-Meier survival curves ...
Schotola Hanna H Department of Anesthesiology, Emergency and Intensive Care Medicine, Georg-August-University Goettingen, Goettingen, - - 2014
Ticagrelor (Brilique(®)) is a novel reversible platelet inhibitor at P2Y12 receptor used in patients with acute coronary syndrome and patients undergoing percutaneous coronary interventions. Unlike clopidogrel (Plavix(®)), ticagrelor has a quicker offset of action, and therefore, it seems that platelet function recovers faster on discontinuation of therapy. These drugs sometimes ...
Fabbri Cristiana C Odontology Division of São Paulo University, Faculdade de Medicina da Universidade de São Paulo, São Paulo, - - 2014
Periodontal disease (POD) may affect rheumatic diseases severity, but there are no data regarding the effect of its treatment on disease activity in SLE patients under immunosuppressive therapy. Forty-nine consecutive SLE patients (SLEDAI ≥ 2) with POD and under corticosteroid and cyclophosphamide pulse therapy (IVCYC) were selected. Periodontal assessment included bleeding gingival ...
Shibata S S Department of Pharmacy, Kitasato Institute Hospital, Tokyo, - - 2014
Itraconazole, a CYP3A inhibitor, is used for the treatment for onychomycosis with a three-cycle pulse therapy over 3 months, but its effects on in vivo CYP3A activity during the entire course remain unknown. Urinary 6β-hydroxycortisol/cortisol ratios were determined in 19 patients with onychomycosis, before therapy, during three cycles of itraconazole pulse ...
Castellucci Lana A LA Department of Medicine, The Ottawa Hospital Research Institute at the University of Ottawa, Ontario, - - 2014
The risk of major bleeding in patients who have completed anticoagulation therapy for unprovoked venous thromboembolism (VTE) is unknown. To report the major bleeding and fatal bleeding rates in patients randomized to placebo or observation (i.e. no anticoagulation therapy) for the secondary prevention of recurrent VTE. We performed a systematic ...
Preuss M M Department of Neurosurgery, University Hospital Leipzig, Leipzig, - - 2014
Introduction: Bevacizumab has been reported to effectively reduce cerebral edema caused by radiation therapy. However, only limited data with a short follow-up in tumor patients are available so far. Patients and Methods: Two children suffering from hemorrhage from arteriovenous malformation (AVM) have been treated with stereotactic radiotherapy and developed radiation-induced ...
Hetzer Sonja - - 2014
Bosentan is a dual endothelin receptor antagonist initially introduced for the treatment of pulmonary arterial hypertension and recently approved for the treatment of digital ulcers in patients with systemic sclerosis (SSc). Our clinical observations indicate that bosentan therapy may be associated with an increased frequency of centrofacial telangiectasia (TAE). Here, ...
P Costello J J MD, Division of Cardiovascular Surgery, Children’s National Health System, Washington DC, US, The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System, Washington DC, - - 2014
Objective: This study examines the efficacy of a comprehensive, multidisciplinary wound management team and negative pressure wound therapy (NPWT) for the treatment of sternal wound infections in congenital heart surgery patients. Method: A single-institution retrospective review of all congenital heart surgery patients with post-operative sternal wound infections who were treated ...
Uhlig Christopher - - 2014
In patients with acute respiratory distress syndrome (ARDS) fluid therapy might be necessary. The aim of this systematic review and meta-analysis is to determine the effects of colloid therapy compared to crystalloids on mortality and oxygenation in adults with ARDS. Randomized controlled trials (RCTs) identified through a systematic literature search ...
Li Xiangling X Renal Division, Peking University First Hospital, Beijing, China;, †Peking University Institute of Nephrology, Beijing, China;, ‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;, §Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China, ‖Department of Nephrology, Affiliated Hospital of Weifang Medical College, Shandong, - - 2014
Current therapy for IgA nephropathy mainly includes renin-angiotensin system inhibitors and adding steroids for patients with persistent proteinuria. This study aimed to evaluate kidney disease progression and its risk factors in a Chinese cohort under current therapy. Patients with IgA nephropathy followed up for at least 12 months from a ...
Palfi Stéphane S AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France. Electronic address: - - 2014
Parkinson's disease is typically treated with oral dopamine replacement therapies; however, long-term treatment leads to motor complications and, occasionally, impulse control disorders caused by intermittent stimulation of dopamine receptors and off-target effects, respectively. We aimed to assess the safety, tolerability, and efficacy of bilateral, intrastriatal delivery of ProSavin, a lentiviral ...
Sotomi Yohei Y Sakurabashi Watanabe Hospital, Cardiovascular Center, Osaka, Japan. Electronic address: - - 2014
Randomized controlled trials concerning pulmonary artery catheters (PACs) use have yielded little evidence of their beneficial effects on survival. This study aimed to evaluate the association between PACs and in-hospital mortality in patients with acute heart failure syndromes (AHFS). The Acute Decompensated Heart Failure Syndromes (ATTEND) Registry is a prospective, ...
Turan Yasemin Y Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey, - - 2014
This double-blind, randomized controlled study was conducted with the aim to investigate the effect of magnetic field therapy applied to the hip region on clinical and functional status in ankylosing spondylitis (AS) patients. Patients with AS (n = 66) who were diagnosed according to modified New York criteria were enrolled in this ...
Deroma Laura L Regional Coordinator Centre for Rare Diseases, University Hospital of Udine, Ple. Santa Maria della Misericordia 15, Udine, 33100, - - 2014
Glycogenosis type II, a genetic muscle-wasting disorder, results in a spectrum of clinical phenotypes. Enzyme replacement therapy is effective in the infantile form of the disease, while little is known about its effectiveness in late-onset disease, especially in juvenile patients. The purpose of this retrospective cohort study was to assess ...
Lichtenstein Gary R GR Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, - - 2014
OBJECTIVES:We assessed potential associations between malignancy and antitumor necrosis factor therapy in patients with Crohn's disease (CD), as this relationship is currently poorly defined.METHODS:Utilizing data from the Crohn's Therapy, Resource, Evaluation, and Assessment Tool (TREAT™) Registry, a prospective cohort study examining long-term outcomes of CD treatments in community and academic ...
Mintz Matthew L ML George Washington University School of Medicine, Washington, DC - - 2014
Abstract Objective: To compare characteristics of hypoglycemic episodes in patients with type 2 diabetes receiving saxagliptin or glipizide add-on therapy to metformin. Patients and Methods: This was a post hoc analysis of an international, randomized, parallel-group, double-blind, active-controlled, phase 3 trial. The 52-week trial and 52-week extension were conducted from ...
Lam Mindy Cw MC Mindy CW Lam, Kenneth Atkinson, Brian Bressler, Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC V6Z 2K5, - - 2014
To determine if early initiation of anti-tumor necrosis factor therapy affects the need for dose escalation. This was a retrospective review of patients receiving infliximab therapy for Crohn's disease (CD) at two outpatient gastroenterology clinics during July 2009 to October 2010. All patients included in the study were biologic agent ...
Wang Kai K Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Autonomous Region, - - 2014
Patent ductus arteriosus (PDA) remains a common congenital heart disease in pediatric patients, and the new trend of catheterization therapy is still associated with some potential risks and complications. Compared with surgical closure, the clinical effect of catheterization therapy in pediatric PDA patients requires meta-analysis. A systematic literature search of ...
Motta Francesco F Department of Paediatric Orthopaedics, "V. Buzzi" Children's Hospital, Milan, - - 2014
Object This single-center study investigated adverse events that occurred in children and adolescent patients treated with intrathecal baclofen (ITB) therapy for spasticity and/or dystonia. Methods In a 14-year period, 430 consecutive patients with a mean age of 13.3 ± 5.9 years received ITB over a mean follow-up period of 8.6 ...
Siegal Deborah M DM Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, - - 2014
Target specific oral anticoagulants (TSOACs) that directly inhibit thrombin (dabigatran) or factor Xa (rivaroxaban, apixaban) are effective and safe alternatives to vitamin K antagonists (VKA) and low molecular weight heparin (LMWH). While these agents have practical advantages compared to VKAs and LMWH, there are no antidotes that reverse their anticoagulant ...
Das Sudipto S Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, - - 2014
To evaluate the efficacy and safety of two different targeted approaches-abatacept or tocilizumab-after rituximab therapy in rheumatoid arthritis, and to explain observed difference in efficacy using blood and synovial studies of interleukin 6 (IL-6) and B cells in patients receiving rituximab therapy. Consecutive series of patients who had discontinued rituximab ...
Castilla-Guerra Luis L From the Department of Internal Medicine (L.C.-G.), Hospital de la Merced, Osuna, Seville, Spain; and the McKnight Brain Institute (R.L.S.), Jackson Memorial, Miller School of Medicine, University of Miami, - - 2014
Patients who develop a new or a recurrent ischemic stroke while taking aspirin, sometimes labeled as aspirin failures, represent a considerable proportion of stroke hospital admissions. In the United States alone, almost 185,000 recurrent strokes occur each year, and approximately a third to half of them develop while on antiplatelet ...
Elbaz Avi - - 2014
Previous studies have shown the effect of a unique therapy with a non-invasive biomechanical foot-worn device (AposTherapy) on Caucasian western population suffering from knee osteoarthritis. The purpose of the current study was to evaluate the effect of this therapy on the level of symptoms and gait patterns in a multi-ethnic ...
Hong Bujung B *Department of Neurosurgery, and †Department of Radiation Oncology, Hannover Medical School, Hannover, - - 2014
The purpose of this study is to compare the outcomes in patients who underwent microsurgical resection for recurrent vestibular schwannoma after microsurgical resection and previous radiation therapy. Retrospective study. University hospital. Fifteen patients, who underwent microsurgical resection for recurrent vestibular schwannoma after previous surgery (group A), and 5 patients, who ...
Merz M M Department of Medicine V, University Hospital of Heidelberg, - - 2014
High-dose therapy (HDT) with autologous stem cell transplantation (ASCT) is considered the standard of care for multiple myeloma (MM) patients <65 years. Safety and outcome of ASCT for patients >65 years is currently uncertain, especially since the introduction of novel agents for induction and maintenance therapy. Furthermore, there are no ...
Watanabe Jonathan H JH Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr., #0714, La Jolla, CA 92093, USA. - - 2014
Statins remain a fundamental component of pharmacologic therapy for hyperlipidemia. Health benefits of statin therapy are jeopardized when adherence is reduced. To (a) assess the association between copayment and copayment type on statin adherence using 2 different thresholds of adherence and (b) identify the incremental change in statin adherence associated ...
Li Taisheng T Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Email: - - 2014
An zidovudine (AZT)-substitution regimen containing 24-week stavudine (d4T) followed by long-term AZT for HIV therapy is potential to trade off short-term AZT-related anemia and long-term risks associated with d4T in resource-limited settings. However, evidence is scarce. This study aims to assess the efficacy and safety of AZT-substitution regimen, aiming to ...
Anderson Stuart J - - 2014
To determine whether field photodynamic therapy (PDT) of actinic keratoses (AKs) using a novel preparation of 5-aminolevulonic acid (ALA) would result in fewer subsequent invasive skin cancers developing on the face.<BR /> A prospective multi-center randomized controlled trial. The protocol was approved by the Bond University Human Research Ethics Committee ...
Castronovo Gaetano - - 2014
Objective: Immunosuppressive drugs may induce an increase of the gingival connective tissue in the extracellular matrix. The aim of this study was to assess the effectiveness of nonsurgical periodontal treatment in reducing gingival overgrowth (GO) in transplant patients taking cyclosporin A (CsA) or tacrolimus (Tcr). Method and Materials: An observational ...
Nevins Marc - - 2014
This investigation was designed and implemented as a single-center, prospective study to evaluate the clinical response to the Laser-Assisted New Attachment Procedure (LANAP). Eight patients with advanced periodontitis were enrolled and treated with full-mouth LANAP therapy and monitored for 9 months. Fullmouth clinical measurements, including clinical attachment level (CAL), probing ...
Truchetti Geoffrey G Département de Sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200 rue Sicotte, C.P. 5000, J2S 7C6, Saint-Hyacinthe, Québec (Truchetti, Bouchard, DesCôteaux, Roy); and College of Agriculture and Biological Sciences, Agricultural Hall, South Dakota State University, Box 2207 South Brookings, South Dakota 57007, USA - - 2014
Few studies have investigated the efficacy of extended ceftiofur therapy and none have focused on extended therapy for naturally occurring clinical mastitis. The objective of this study was to compare the efficacy of extended intramammary ceftiofur therapy of 8 d duration with a standard 2-day regimen for the treatment of ...
Wang Lily C LC Department of Urology, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York, - - 2014
A 64-year-old man with HIV on antiretroviral therapy (including atazanavir, a protease inhibitor) presented with left flank pain, nausea and vomiting. A kidney stone was suspected, and a CT scan demonstrated left hydronephrosis but failed to demonstrate nephrolithiasis or extrinsic compression. The patient had a ureteral stent placed which relieved ...
Vafaeimanesh Jamshid J Clinical Research Development Center, Qom University of Medical Sciences, Qom, - - 2014
To compare a triple-therapy regimen based on change of antibiotic (azithromycin and clarithromycin) for the eradication of Helicobacter pylori in hemodialysis (HD) patients, we studied in a prospective, randomized, double-blinded clinical trial 39 patients who had dyspepsia and showed two positive results from the diagnostic tests of H. pylori infection ...
Saito Eiko E Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, - - 2014
Aims: To evaluate the efficacy and safety of salvage therapy, and to identify risk factors of operative complications among hospitalized ulcerative colitis (UC) patients. Patients and Methods: We evaluated 88 UC patients hospitalized at our center between April 2010 and November 2012. We compared characteristics of corticosteroid-refractory patients treated with ...
Asher Gary N GN Department of Family Medicine, University of North Carolina at Chapel - - 2014
Not only was a shorter course of glucocorticoid therapy as effective as a 14-day regimen, but there was no difference in the time to next exacerbation.
Parma Marta - - 2014
Context • Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women during their fertile years. BV prevalence runs from 10%-50%, in part due to the high rate of recurrence after standard treatment. Women with BV may experience a decreased quality of life and are at risk ...
Kim Won W Department of Urology, Yonsei University Wonju College of Medicine, Wonju, - - 2014
To assess changes in lower urinary tract symptoms (LUTS), prostate volume, and serum prostate-specific antigen (PSA) after discontinuation of 5-alpha reductase inhibitor (5ARI) combination therapy in patients with benign prostatic hyperplasia (BPH). From December 2003 to December 2012, data were collected retrospectively from 81 men more than 40 years of ...
Koido Shigeo S Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, - - 2014
Previous work has demonstrated that intestinal bacteria, such as Fusobacterium varium (F. varium), contribute to the clinical activity in ulcerative colitis (UC); thus, an antibiotic combination therapy (amoxicillin, tetracycline, and metronidazole (ATM)) against F. varium can induce and maintain UC remission. Therefore, we investigated whether ATM therapy induces a long-term ...
Xia Huan H Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, - - 2014
Talc pleurodesis has been widely used to control malignant pleural effusion; however, it is still not clear whether talc pleurodesis is more effective than other local therapies. We performed a meta-analysis to evaluate the efficacy and safety of talc pleurodesis in the management of malignant pleural effusion. PubMed, Embase, and ...
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