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Results 301 - 350 of 4645
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Arshad Aysha A Arrhythmia Institute, Valley Health System, New York, New York and Ridgewood, New - - 2014
There are a variety of periprocedural anticoagulation strategies for atrial fibrillation (AF) ablation, including the use of dabigatran. It is unclear which strategy is superior. To compare the safety and efficacy of anticoagulation with uninterrupted warfarin, dabigatran, and warfarin with heparin bridging in patients undergoing ablation of AF at four ...
Otani Keisuke K Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, - - 2014
Radiation-induced organizing pneumonia (RIOP) is an important complication of postoperative radiotherapy for breast cancer. Unfortunately, conventional corticosteroid therapy is frequently associated with relapses. The aim of this retrospective study was to evaluate the outcomes of steroid treatment in patients with RIOP. In total, 26 patients diagnosed with RIOP from among ...
Yamamoto Kei K Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, - - 2014
The perioperative risk of non-cardiac surgery (NCS) in the patients on antiplatelet therapy after percutaneous coronary intervention (PCI) remains unclear. This study was a retrospective and single center study. Between January 2008 and December 2011, 198 patients who had already received PCI underwent NCS in our hospital. Among them, 63 ...
Maggio Angelo A Medical Physics, San Raffaele Scientific Institute, Milan, Italy. Electronic address: - - 2014
To evaluate the efficacy of sodium butyrate enemas (NABUREN) in prostate cancer radiation therapy (RT) in reducing the incidence, severity, and duration of acute RT-induced proctitis. 166 patients, randomly allocated to 1 of 4 groups (rectal sodium butyrate 1 g, 2 g, or 4 g daily or placebo), were treated with NABUREN during ...
Kwak Min Seob - - 2014
The natural course of Crohn's disease (CD), with continuing relapses and remissions, leads to irreversible intestinal damage. Early adoption of immunomodulator therapy has been proposed in order to address this; however, it is still uncertain whether early immunomodulator therapy could affect the natural course of the disease in real practice. ...
El-Hayek Georges G Department of Cardiology, Mount Sinai St. Luke's Hospital, New York, New - - 2014
Current guidelines recommend 12 months of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation in the absence of increased bleeding risk. Studies have suggested that early discontinuation of DAPT can result in an increased risk of stent thrombosis. However, given the potential for major bleeding, the optimal duration of DAPT ...
Deharo P P Département de cardiologie, CHU Timone, 13385 Marseille, France; Inserm, UMR1062, « Nutrition, Obesity and Risk of Thrombosis », 13385 Marseille, France; Faculté de médecine, Aix-Marseille université, 13385 Marseille, France. Electronic address: - - 2014
Statin therapy is a cornerstone therapy for secondary prevention after acute coronary syndrome (ACS). However, the use of these drugs can be limited by side effects, mainly muscular pain. Ezetimibe is a newer lipid-lowering agent, with fewer side effects. The present study was designed to compare a commercially available association ...
Chuah Sai Yee SY Department of Dermatology, National Skin Centre, - - 2014
We reviewed the clinical characteristics and therapeutic response in cases of newly diagnosed bullous pemphigoid at the National Skin Centre between June 2009 and December 2010. Most (76%, n = 68/90) achieved clinical remission within 6 months of commencement of therapy. Oral mucosal involvement was identified as a risk factor associated with ...
Kirchheiner Kathrin K Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna/General Hospital of Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Austria. Electronic address: - - 2014
Brachytherapy in the treatment of locally advanced cervical cancer has changed substantially because of the introduction of combined intracavitary/interstitial applicators and an adaptive target concept, which is the focus of the prospective, multi-institutional EMBRACE study (www.embracestudy.dk) on image-guided adaptive brachytherapy (IGABT). So far, little has been reported about the development ...
Dee Brian B Brian Dee, Pharm.D., BCPS, BCNSP, is Clinical Pharmacy Specialist-Critical Care/Nutrition Support; Lindsey Lombardi Thomas, Pharm.D., BCOP, is Clinical Pharmacy Specialist-Stem Cell Transplantation; and Alison Gulbis, Pharm.D., BCOP, is Clinical Pharmacy Specialist-Stem Cell Transplantation, Division of Pharmacy, University of Texas MD Anderson Cancer Center, - - 2014
The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented. A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep ...
Leal Nicole V NV Instituto Paraibano de Pesquisa, Campina Grande, Paraíba, - - 2014
The objective of this study was comparative use of magnesium sulfate for 12 compared with 24 hours in postpartum women with stable severe preeclampsia. An open, randomized clinical trial was conducted with 120 postpartum women with severe preeclampsia; 60 were allocated to receive magnesium sulfate for 24 hours and 60 ...
Spear Scott L SL Washington, D.C. From the Department of Plastic Surgery, Georgetown University - - 2014
Although it is well established that reconstruction of the irradiated breast is associated with diminished cosmetic results and more frequent complications, little is known about the specific effects of radiation therapy on the reconstructive outcomes after nipple-sparing mastectomy. Patients who had nipple-sparing mastectomy and had either previous radiation therapy for ...
Saglietti Giuseppe G Struttura Operativa Complessa di Diabetologia e Malattie Metaboliche, ASL VCO - Via Mazzini, 96, 28887, Omegna (VB), Italy, - - 2014
Diabetes mellitus is a complex, progressive disease that can lead to complications if it is not strictly controlled. The literature suggests that only 50 % of Italian patients with type 2 diabetes mellitus (T2DM) achieve guideline-recommended levels of glycaemic control, suggesting that treatment regimens need to be improved. The present study ...
Shaw Joshua J JJ 1 Department of Surgery, University of Massachusetts Medical School , Worcester, - - 2014
Abstract Background: The utility of hyperbaric oxygen therapy (HBOT) in the treatment of necrotizing soft tissue infections (NSTIs) has not been proved. Previous studies have been subject to substantial selection bias because HBOT is not available universally at all medical centers, and there is often considerable delay associated with its ...
Jones Douglas W DW Vascular and Endovascular Surgery, New York Presbyterian Hospital - Weill-Cornell Medical Center, New York, NY, - - 2014
After endovascular therapy, duplex ultrasound surveillance to detect restenosis guides clinical decisions and defines treatment failure. However, the correlation between duplex ultrasound and symptom recurrence remains unclear. We reviewed our institutional experience (2007-2010) to identify patients undergoing endovascular therapy for claudication. The association between post-intervention systolic velocity ratio and patient-reported ...
Kahloon Arslan A Department of Internal Medicine, University of Tennessee College of Medicine, Chattanooga, 979 East Third Street, Suite C-825, Chattanooga, TN, 37403, USA, - - 2014
Gastric variceal bleeding is associated with significant morbidity and mortality and limited endoscopic therapeutic options. The aim of this study was to evaluate the short- and long-term efficacy and safety of endoscopic therapy with 2-octyl-cyanoacrylate in patients with gastric variceal bleeding. A single-center retrospective review of patients receiving endoscopic therapy ...
Nammas Wail W Heart Center, Turku University Hospital and University of Turku , Turku , - - 2014
Abstract Background. The FinPAC trial showed that the strategy of uninterrupted oral anticoagulation (OAC) was non-inferior to interrupted OAC for the primary outcome of bleeding and thromboembolic complications in patients undergoing cardiac rhythm management device (CRMD) implantation. Methods. We conducted a post hoc analysis of the FinPAC data to explore ...
Kido Larissa Akemi LA Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, - - 2014
The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. 90 male FVB mice were divided into: Young (18weeks old) and Senile (52weeks old) groups; Finasteride group: Finasteride (20mg/kg); SU5416 group: SU5416 (6mg/kg); TNP-470 group: ...
Gupta Aditya K - - 2014
Background:Topical therapies for onychomycosis are associated with less adverse events than systemic therapies, but poor nail penetration limits their efficacy. Consequently, an efinaconazole 10% nail solution was developed.Objective:To review the evidence supporting the usefulness of efinaconazole monotherapy in onychomycosis management.Methods:PubMed and clinicaltrials.gov databases and abstracts from the 2013 annual meeting ...
Jin Chunlan C Chunlan Jin, MD, L.Ac., Attending physician, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, and Division of Gynecology, Hospital of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Dong Cheng District, Beijing, China. Xinyao Zhou, MD, Attending physician, Division of Internal Medicine, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Xi Cheng District, Beijing, China. Ran Pang, MD, Attending surgeon, Division of Urology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Xi Cheng District, Beijing, China, and Visiting scientist, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, - - 2014
To examine the effectiveness of combination therapy of electroacupuncture and tolterodine in treating female patients with mixed urinary incontinence. Seventy-one women with mixed urinary incontinence were recruited to receive electroacupuncture therapy or combination therapy with electroacupuncture and tolterodine 2 mg orally twice a day for 8 weeks. In electroacupuncture therapy, ...
Abe Tatsuya T Department of Proctology, Kunimoto Hospital, Asahikawa, - - 2014
Aluminum potassium sulfate and tannic acid is a sclerosant used for sclerosing therapy in the treatment of hemorrhoids, and a Leeds-Keio artificial ligament is a new anal-encircling material for the management of rectal prolapse. The aim of this study was to evaluate clinical data and recurrence rates in patients with ...
Ahmed Wasim W Department of Medicine, King Abdul Aziz Medical City, National Guard Health Affairs, Al Ahsa, Saudi - - 2014
Acute kidney injury (AKI) in the intensive care unit (ICU) is commonly caused by severe sepsis and septic shock. There is limited data regarding the incidence and outcomes of patients developing AKI treated with early goal-directed therapy (EGDT). Our aim was to observe the incidence and outcomes of patients with ...
Scarano Antonio A From the *Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy; †Department of Oral Rehabilitation, School of Dental Medicine, Tel-Aviv University, Israel; and ‡Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara, - - 2014
The aim of this study was to evaluate the use of calcium sulfate (CaS) as a hemostatic agent after tooth extraction in patients with anticoagulant drug therapy.A total of 30 patients undergoing anticoagulant therapy (22 women and 8 men) with a mean age of 54.6 years (SD = 9.2 years), ...
Leow O M - - 2014
This study aimed to evaluate the efficacy and safety of intra-articular glucocorticoid (IAG) injections in our institution in children with juvenile idiopathic arthritis (JIA). This is a retrospective assessment of IAG injections performed by the Department of Paediatrics, National University Hospital, Singapore, from October 2009 to October 2011. A total ...
Liberini P P Division of Neurology, Brescia General Hospital, Piazza Spedali Civili 1, Brescia, Italy, - - 2014
In 2013 the Italian Pharmacy Agency (AIFA) approved onabotulinumtoxin A injection to prevent headaches in adult patients with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine) that has not responded to at least three prior pharmacological prophylaxis therapies and whose condition ...
Chedid Victor V University of Pittsburgh Medical Center, Department of Internal Medicine, Pittsburgh, Pennsylvania (Dr Chedid), United - - 2014
Patients with small intestine bacterial overgrowth (SIBO) have chronic intestinal and extraintestinal symptomatology which adversely affects their quality of life. Present treatment of SIBO is limited to oral antibiotics with variable success. A growing number of patients are interested in using complementary and alternative therapies for their gastrointestinal health. The ...
Bron Morgan M Takeda Pharmaceuticals International, Inc., Deerfield, - - 2014
Current type 2 diabetes mellitus (T2DM) treatment involves progressive interventions from lifestyle changes to pharmacological therapies. Previous studies found that combination therapy with a dipeptidyl peptidase-4 inhibitor (DPP-4i) and pioglitazone (PIO) is more effective than monotherapies in treating poorly controlled T2DM, but there is no consensus on whether these drugs ...
Cerezo-Manchado Juan Jose JJ Hospital Universitario Morales Meseguer & Centro Regional de Hemodonacion, University of Murcia, Ronda de Garay s/n, 30003, IMIB, Murcia, - - 2014
Aim: To analyze VKORC1, CYP2C9 and CYP4F2 polymorphisms in relation to the main outcomes in the first stages of acenocoumarol therapy. Patients & methods: Nine hundred and forty one patients who had started therapy and in whom time to stable dosage, time to over-anticoagulation and adverse events occurred during 3 ...
Akcan Alper A Department of General Surgery, Erciyes University School of Medicine, Kayseri, - - 2014
Idiopathic granulomatous mastitis (IGM) is an uncommon chronic inflammatory disease of the breast with uncertain optimal treatment regimen. In this study, our purpose was to report our clinical experience with 74 IGM patients who were treated wide local excision with or without steroid therapy. 74 cases diagnosed histologically as IGM ...
Sharifi Seyed Hossein Hosseini SH Shahid Labbafinejad Medical Center, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, I.R. - - 2014
Objective: To compare the safety and efficacy of combined therapy using sildenafil and tamsulosin for management of acute urinary retention (AUR) with tamsulosin alone in patients with benign prostate hyperplasia (BPH). Materials and Methods: 101 patients were enrolled in a randomized placebo-controlled study from June 2009 to April 2012. Patients ...
Falahatkar Siavash S Urology Research Center, Razi Hospital, Guilan University of Medical - - 2014
Objective: To compare the outcomes of bipolar transurethral vaporization of the prostate (TUVP) with bipolar transurethral resection of the prostate (TURP). Materials and Methods: In a prospective randomized trial, 88 patients with moderate to severe lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH) underwent bipolar TUVP (N = ...
de Jong P H PH Department of Rheumatology, University Medical Center, Rotterdam, The - - 2014
To compare 1-year clinical efficacy of (1) initial triple disease-modifying antirheumatic drug therapy (iTDT) with initial methotrexate (MTX) monotherapy (iMM) and (2) different glucocorticoid (GC) bridging therapies: oral versus a single intramuscular injection in early rheumatoid arthritis. In a single-blinded randomised clinical trial patients were randomised into three arms: (A) ...
Baros Duka Ninković - - 2014
Psoriasis is a chronic, inflammatory, immune-mediated skin disease. In addition to standard therapeutic modalities (antibiotics, cytostatics, phototherapy, photochemotherapy and retinoids), nonstandard methods can be used in the treatment of psoriasis. This includes balneotherapy which is most commonly used in combination with therapeutic resources. The aim of this research was to ...
Nguyen Harrison P HP Baylor College of Medicine, Houston, - - 2014
Infantile hemangiomas (IH) are common benign vascular tumors seen in children. Although the majority will improve spontaneously without treatment, a small subset will require therapy due to a variety of complications. Less than a decade ago, propranolol replaced corticosteroids as first-line treatment for most IH and it has proven to ...
Gompelmann Daniela D Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, and Translational Research Center Heidelberg, Member of the German Center for Lung Research, Heidelberg, - - 2014
Background: Patients who achieve significant target lobe volume reduction (TLVR) following endobronchial valve (EBV) treatment may experience substantial improvements in clinical outcome measures. However, in cases of rapid TLVR, the risk of pneumothorax increases due to parenchymal rupture of the adjacent untreated lobe. Target lobe collapse may be more likely ...
Min Yang Won YW Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
The occurrence of gastroesophageal reflux disease (GERD) is known to be associated with lower post-treatment lower esoph-ageal sphincter pressure in patients with achalasia. This study aimed to elucidate whether GERD after pneumatic balloon dilata-tion (PD) has a prognostic role and to investigate how the clinical course of GERD is. A ...
van Zeller Mafalda M Drs van Zeller and Almeida and Ms Eusébio are affiliated with the Department of Pulmonology, Centro Hospitalar de São João, Porto, - - 2014
Treatment adherence is widely recognized as a critical problem in long-term oxygen therapy, particularly in ambulatory liquid oxygen (LOX) systems. Adherence-monitoring strategies may be helpful in managing patients. We evaluated subjects' adherence to LOX using VisionOx and compared these results with the subjects' own adherence diaries and self-reported perceptions of ...
Zeisberg A A Department of Ophthalmology, Charité University Medicine Berlin, Campus Benjamin Franklin, 12200, Berlin, - - 2014
The aim of this retrospective study was to determine the efficacy of proton beam irradiation in choroidal hemangioma in a long-term follow-up. A total dose of 20 Cobalt Gray equivalent (CGE) was administered to 50 eyes of 50 patients from September 1998 to September 2010. All treated patients presented with ...
Varkonyi Istvan I Kenezy Gyula Hospital and Outpatient Facility, Debrecen, - - 2014
We completed a prospective study of 164 patients involved in a Clostridium difficile surveillance program, evaluating a range of variables such as disease severity, treatment regimen, and known clinical risk factors, for their effect on case lethality. The aim of this study was to determine if there are any additional ...
Yeon Gyu-Min GM 1 Department of Pediatrics, College of Medicine, Kosin University , Busan, - - 2014
Abstract Objective: Few studies have been conducted among pediatric patients to examine clinical outcomes associated with the combined use of Oriental medicine and other therapies to treat epilepsy. The purpose of this study was to examine the clinical and laboratory characteristics of children with epilepsy being treated with traditional Korean ...
Yang Na Rae NR Department of Neurosurgery, Ewha Womans University School of Medicine, Mokdong Hospital, 911-1 Mok-dong, Yangcheon-gu, Seoul, 158-710, - - 2014
Problems that the risk of using antiplatelet/anticoagulant may overwhelm its benefits have been raised. We analyzed patients with spontaneous intracerebral hemorrhage who had received antiplatelet/anticoagulant therapy. A consecutive series of patients with spontaneous intracerebral hemorrhage who underwent brain computed tomographic (CT) scans within 48 h from attack. We analyzed the clinical ...
Flury Baharak Babouee - - 2014
Vertebral osteomyelitis (VO) may lead to disabling neurologic complications. Little evidence exists on optimal antibiotic management. All patients with primary, non-implant VO, admitted from 2000-2010 were retrospectively analyzed. Patients with endocarditis, immunodeficiency, vertebral implants and surgical site infection following spine surgery were excluded. Persistence of clinical or laboratory signs of ...
Song Gi-Won GW 1 Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 2 Address correspondence to: Sung-Gyu Lee, M.D., F.A.C.S., 388-1 Pungnab2-dong, Songpa-gu, Seoul, - - 2014
The use of rituximab (Rit) to prevent antibody-mediated rejection (AMR) of ABO-incompatible (ABOi) adult living donor liver transplants (ALDLTs) has raised questions about the role of local graft infusion therapy (LGIT) and splenectomy (SPN); however, they are still regarded as essential components of the desensitization (DSZ) protocol. The DSZ protocol ...
Mizobe Michio M Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, - - 2014
The aim of this study was to examine the impact of CYP2C19 genotype on clinical outcome in coronary artery disease (CAD) patients with or without diabetes mellitus (DM). CYP2C19 polymorphism and DM are associated with increased risk of cardiovascular events during antiplatelet therapy following stent implantation. Platelet reactivity during clopidogrel ...
Kanji Hussein D HD Department of Critical Care Medicine, University of British Columbia; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, - - 2014
The purpose of the study was to compare the effect of limited echocardiography (LE)-guided therapy to standard management on 28-day mortality, intravenous fluid prescription, and inotropic dosing following early resuscitation for shock. Two hundred twenty critically ill patients with undifferentiated shock from a quaternary intensive care unit were included in ...
Morgan C Ll CL Global Epidemiology, Pharmatelligence, Cardiff, - - 2014
To compare the risk of major adverse cardiovascular events (MACE) and mortality for combination therapies with metformin and either sulfonylurea (SU) or DPP-4 inhibitor (DPP-4i). Data were from the UK Clinical Practice Research Datalink (CPRD). Patients with type 2 diabetes were selected if initiated with combination therapies comprising metformin plus ...
Sulz Michael C MC Department of Gastroenterology and Hepatology, Kantonspital St. Gallen, - - 2014
Hemospray (Cook Medical, Winston-Salem, North Carolina, USA) is a hemostatic agent recently introduced for the management of upper gastrointestinal bleeding (GIB). To date, there is little experience with this fairly new hemostatic tool. The aim of this case series was to reflect the use and effectiveness of Hemospray as a ...
Cahn Pedro P Clinical Research Department, Fundación Huésped, Buenos Aires, Argentina. Electronic address: - - 2014
Daily oral triple therapy is effective at halting HIV disease progression, but can have toxic effects and is costly. We investigated whether dual therapy with lopinavir and ritonavir plus lamivudine is non-inferior to standard triple therapy. The GARDEL study (Global AntiRetroviral Design Encompassing Lopinavir/r and Lamivudine vs LPV/r based standard ...
Schroeder A S AS Department of Paediatric Neurology and Developmental Medicine, Hauner Children's Hospital, University of Munich, Germany; German Center for Vertigo and Balance Disorders, IFB(LMU), University of Munich, Germany. Electronic address: - - 2014
Robot-enhanced therapies are increasingly being used to improve gross motor performance in patients with cerebral palsy. To evaluate gross motor function, activity and participation in patients with bilateral spastic cerebral palsy (BS-CP) after Robot-enhanced repetitive treadmill therapy (ROBERT) in a prospective, controlled cohort study. Participants trained for 30-60 min in each of ...
Chon Min Ku MK Division of Cardiology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, - - 2014
Pulmonary thromboembolism (PTE) is a common clinical condition related to significant mortality. Furthermore, patients with PTE presenting with right heart thrombus show higher mortality due to rapid hemodynamic deterioration. But the optimal treatment of massive PTE is controversial although various methods have been developed and improved. Here, we presented a ...
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