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Results 301 - 350 of 4821
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Santana Rafael Santos RS Universidade de - - 2014
To evaluate the improper use of antimicrobials during the postoperative period and its economic impact. We conducted a prospective cohort study by collecting data from medical records of 237 patients operated on between 01/11/08 and 31/12/08. from the 237 patients with the information collected, 217 (91.56%) received antimicrobials. During the ...
Clegg F F Gastroenterology, Aberdeen Royal Infirmary, Aberdeen, - - 2014
Hepatocellular cancer (HCC) is a recognised complication of liver cirrhosis.(1) The cause of liver cirrhosis is varied, but the prevalence of certain conditions like non-alcoholic fatty liver disease (NAFLD) is rising.(2) This study aimed to identify the time trends of HCC over the last 10 years focusing on the aetiopathology ...
Patel J J Watford General Hospital, Watford, - - 2014
Endoclot™ is a non-toxic topical haemostatic powder consisting of absorbable modified polymers. We previously described our early experience using Endoclot™ as an adjunct haemostatic endoscopic therapy in 6 patients undergoing elective/emergency upper or lower gastrointestinal (GI) endoscopy.(1) We now present the largest case series to date describing the use of ...
Harrow P P Department of Gastroenterology, Queen's Hospital, Romford, - - 2014
Leucocytapheresis, the extracorporeal removal of leucocytes from patient's blood, has conflicting evidence of benefit in ulcerative colitis (UC). Numerous studies have recorded short term clinical remission rates while few have examined the long term end-points of colectomy, death and steroid free remission. Queen's Hospital, Romford is one of the largest ...
Yang Jeong Hoon JH Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South - - 2014
This study sought to investigate the association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). Limited data are available on the efficacy of beta-blocker therapy for secondary prevention in STEMI patients. Between November 1, 2005 and September ...
Tofuku Katsuhiro K Department of Orthopaedic Surgery, Imakiire General Hospital, Kagoshima, - - 2014
A retrospective study. The purpose of this study was to evaluate outcomes in patients with pyogenic spondylitis accompanied by iliopsoas abscess who were treated by percutaneous drainage combined with hyperbaric oxygen (HBO) therapy. To the best of our knowledge, there have been no previous reports of the use of percutaneous ...
Augustine Daniel D Bristol Heart - - 2014
As part of the care of breast cancer patients considered for trastuzumab, the measurement of LV ejection fraction (EF) pre-treatment is required. Current protocols recommend that EF is then repeated at 3 monthly intervals following the commencement of treatment. We evaluated the use of mitral annular plane systolic excursion (MAPSE) ...
Davidson Bruce L BL Division of Pulmonary and Critical Care Medicine,University of Washington School of Medicine, Seattle, - - 2014
Combined anticoagulant and aspirin therapy is associated with increased bleeding risk in patients with atrial fibrillation, but the bleeding risk of combined use of anticoagulant and nonsteroidal anti-inflammatory drugs (NSAIDs) is poorly documented. To estimate the bleeding risk of combined anticoagulant (rivaroxaban or enoxaparin-vitamin K antagonist [VKA]) and NSAID or ...
Alfaqeeh S A - - 2014
Background: Gingival Crevicular Fluid (GCF) changes occur during orthodontic tooth movement and this could serve as a potential indicator to the response to active treatment. Aim: The objective of the study is to assess the changes in the GCF volume and the levels of Alkaline Phosphatase (ALP) during early phase ...
Sood R R Leeds Gastroenterology Institute, St James University Hospital, Leeds, - - 2014
Azathioprine (AZA) is an established treatment for ulcerative colitis (UC). However, controversy exists regarding its efficacy in inducing and maintaining clinical remission, particularly with the advent of biologics which, unlike AZA, have been tested in large, rigorously designed randomised controlled trials. We studied the effectiveness of AZA as second-line therapy ...
Churchhouse Am A GI Unit, Western General Hospital, Edinburgh, - - 2014
Patients with severe Ulcerative Colitis (UC) are commonly identified using the Truelove and Witts(1) criteria on presentation. The Travis(2) and Ho(3) scores are subsequently used to identify patients with severe UC who are at high risk of failing medical therapy and needing second line therapy or colectomy. To date there ...
Farouk Ridzuan R Department of Surgery, National University Hospital, - - 2014
To estimate the risk of recurrent fissure in ano after sphincter preserving treatments. A retrospective case note review, combined with a telephone survey was conducted for all patients treated for a chronic anal fissure between 1998 and 2008. Six hundred and twelve patients (303 women: mean age, 39 years; range, ...
Kennedy Na N GI Unit, Western General Hospital, Edinburgh, - - 2014
Infliximab and adalimumab have established roles in IBD therapy. NICE and SMC guidelines mandate reassessment of disease activity after 12 months. Therapy should ordinarily be discontinued where clinical remission and mucosal healing has been achieved. However, there are presently few data about outcomes of anti-TNF withdrawal. We conducted a retrospective ...
Imperatore Vittorio V Department of Urology, Buon Consiglio Fatebenefratelli Hospital, Naples. - - 2014
Objectives: To compare the efficacy and safety of tamsulosin and silodosin in the context of medical expulsive therapy (MET) of distal ureteric stones. Patients and methods: Observational data were collected retrospectively from patients who received silodosin (N = 50) or tamsulosin (N = 50) as MET from January 2012 to ...
Brain Matthew J MJ School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. - - 2014
The effectiveness of continuous renal replacement therapy (CRRT) increases when unplanned circuit failure is prevented. Adequate anticoagulation is an important component. Although heparin is the predominating anticoagulant, calcium chelation with citrate is an alternative, but systemic calcium monitoring and supplementation increase the complexity of CRRT. We assessed efficacy and safety ...
Danson Edward E King's College - - 2014
There is limited data describing outcomes in patients undergoing percutaneous coronary intervention (PCI) or medical therapy who have been turned down for surgical revascularisation (CABG) on the basis of prohibitive risk. The independent predictors of morbidity and mortality; and role of clinical or anatomical scoring systems in this patient group ...
Aggarwal D D Gastroenterology, Pennine Acute Hospitals NHS Trust, Manchester, - - 2014
Patients with Ulcerative Colitis [UC] may be exposed to ionising radiation for evaluation of disease with inherent risks from protracted exposure. Meanwhile, bolder definitions of disease control with evolving treatment paradigms have led to earlier introduction of biological therapy. Our aim was to compare the effective radiation dose prior to ...
Hanson Neil A NA From the *Department of Anesthesiology, Virginia Mason Medical Center; †Department of Anesthesiology, Physicians Anesthesia Service, Seattle, Washington; and ‡Axio Research, Seattle, - - 2014
Adductor canal blocks have shown promise in reducing postoperative pain in total knee arthroplasty patients. No randomized, controlled studies, however, evaluate the opioid-sparing benefits of a continuous 0.2% ropivacaine infusion at the adductor canal. We hypothesized that a continuous adductor canal block would decrease postoperative opioid consumption. Eighty subjects presenting ...
Toker Serdar S Meram Faculty of Medicine, Department of Orthopaedic Surgery, Konya Selcuk University, Konya, - - 2014
Nonadherence to postoperative therapy protocols can adversely affect the outcome after flexor tendon surgery. In this study, we hypothesize that patients with partial or no insurance coverage for their aftercare are less likely to attend postoperative therapy sessions and have a higher incidence of a poorer outcome than those who ...
Razavi Mahmood K MK St Joseph Hospital Heart & Vascular Center, 1140 West La Veta Ave, Suite 850, Orange, CA, 92868, USA, - - 2014
The basic treatment of deep vein thrombosis (DVT) over the past several decades has consisted of anticoagulation only, with inferior vena cava filtration for those who either failed or could not tolerate anticoagulation. Until recently no randomized trials had studied the efficacy of thrombolysis in DVT despite advances in techniques ...
Crosswell Ashley A Department of Intensive Care, The Alfred, Melbourne, VIC, Australia. - - 2014
To determine the influence of vascular access site on continuous renal replacement therapy (CRRT) filter survival. Retrospective study of the records of patients who received CRRT in The Alfred intensive care unit from June 2011 to May 2012. Filter run time. We matched filter run time to site and type ...
Johnson He H Gastroenterology, Royal Bournemouth Hospital, Bournemouth, - - 2014
Despite the advancement and introduction of new biological therapies, thiopurines remain effective treatment options for the maintenance of remission for both ulcerative colitis (UC) and Crohn's disease (CD). Once tolerated and therapeutic, thiopurines have many advantages over biologics for long-term maintenance therapy. However, it has been documented that intolerance and ...
Moulakakis Konstantinos G KG Department of Vascular Surgery, Athens University Medical School, Attikon University Hospital, Athens, - - 2014
Purpose : To review the published outcomes of aortic endograft infection treated with preservation of the stent-graft. Methods : An extensive electronic health database search was undertaken to identify all articles published up to May 2013 that reported endograft infection after endovascular aneurysm repair (EVAR) in which treatment included preservation ...
Oh Dong Hyun - - 2014
Recent prospective studies have shown that the sequential therapy has not achieved the target Helicobacter pylori eradication rate of > 80% in Korea. The aim of this study was to therefore assess the efficacy of the hybrid therapy as a first-line treatment for H. pylori eradication in a prospective trial. From ...
Reddy S V Krishna SV Department of Urology, Narayana Medical College and Hospital, Nellore, - - 2014
To study the effects of long-term treatment with potassium magnesium citrate and vitamin B-6 prophylaxis (Urikind-KM6; 1,100-mg potassium citrate, 375-mg magnesium citrate, and 20-mg pyridoxine hydrochloride/5 mL) every 8 hours over 3 years. A total of 247 patients with recurrent idiopathic hypocitraturia with or without hyperuricosuria and randomized controls were ...
Nishikawa Hiroki H Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan - - 2014
Aim: To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. Patients and Methods: A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: patients treated with non-transplant ...
Ray Kathryn J KJ F. I. Proctor Foundation, University of California, San Francisco2Department of Epidemiology and Biostatistics, University of California, San - - 2014
Scarring from bacterial keratitis remains a leading cause of visual loss. To determine whether topical corticosteroids are beneficial as an adjunctive therapy for bacterial keratitis if given early in the course of infection. The Steroids for Corneal Ulcers Trial (SCUT) was a randomized, double-masked, placebo-controlled trial that overall found no ...
Hackshaw Michelle D MD 5 Crescent Dr., Philadelphia, PA 19112. - - 2014
Pazopanib is an oral tyrosine kinase inhibitor with demonstrated efficacy and tolerability in patients with advanced renal cell carcinoma (RCC). To examine pazopanib persistence and compliance (adherence) and other drug utilization patterns in both treatment-naïve (first-line) patients and those previously treated with RCC therapy in the real-world setting. Key factors ...
Russo E E Medicine, Imperial College London, - - 2014
A common therapeutic strategy in events of failure of the first-line anti-TNFα biologic in Crohn's Disease (CD) is to switch to another biologic agent from the same class. There is a significant body of evidence to support using adalimumab (ADA) as second-line therapy following infliximab (IFX) intolerance or loss of ...
Holleran G G Department of Clinical Medicine, Trinity College Dublin, Tallaght, IrelandGastroenterology, Tallaght Hospital, Tallaght, - - 2014
Angiodysplasias account for up to 50% of causes of small bowel bleeding and due to their relative inaccessibility and the intermittent nature of their bleeding they present a particular therapeutic challenge. Endoscopic ablation with APC is the most efficacious at reducing re-bleeding rates, however; its effect is short-lived and not ...
Steed H H Gastroenterology, University Hospital North Staffordshire, Stoke-on-Trent, - - 2014
Prescription of a-TNF therapy in UC in the UK is limited to acute severe colitis by NICE. Increasingly physicians are under pressure from patients to offer an alternative to the traditional limited therapeutic options and this has resulted in the drug being used in the subacute setting, as it is ...
Shi Xuehui X Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Science Key Labratory, Beijing 100730, - - 2014
Photodynamic therapy (PDT) has been recommended as a main treatment for idiopathic choroidal neovascularization (I-CNV). But the visual results of PDT were inconsistent and variable, and PDT may bring severe damage to the retinal pigment epithelium and choriocapillaries. In recent years, intravitreal ranibizumab therapy, showing favorable visual outcomes, has developed ...
Wynn Gareth G Institute of Cardiovascular Medicine and Science, - - 2014
The most frequent complications of AF Ablation (AFA) are related to vascular access but there is little published evidence as to how these can be minimised. In 2012 the European Society of Cardiology clearly stated in their updated guidelines that "improving safety of catheter ablation should be a primary goal ...
Suzuki Satoshi S 1Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia. 2Australian and New Zealand Intensive Care Research Centre, Melbourne, VIC, - - 2014
To assess the feasibility and safety of a conservative approach to oxygen therapy in mechanically ventilated ICU patients. Pilot prospective before-and-after study. A 22-bed multidisciplinary ICU of a tertiary care hospital in Australia. A total of 105 adult (18 years old or older) patients required mechanical ventilation for more than ...
Patel Vc V Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, - - 2014
Rifaximin-α is a non-absorbable antibiotic increasingly being used for the secondary prevention of recurrent overt hepatic encephalopathy (HE) in the UK. The therapeutic mechanism of rifaximin has yet to be elucidated, with reduction in gut ammonia production postulated. We undertook a UK multi-centre retrospective audit of patients receiving rifaximin therapy ...
Park Seong Doo SD Graduate School of Physical Therapy, Daejeon University, Daejeon, - - 2014
The purpose of this study is to investigate that effect of action observation training (AOT) on knee joint function and balance in total knee replacement (TKR) patients. The subjects consisted of eighteen post-TKR patients. All participants underwent conventional physical therapy. In addition, patients in the AOT group (n= 9) were ...
Blaker Pa P Gastroenterology, Guys and St Thomas Hospitals' NHS Foundation Trust, London, - - 2014
15% of patients with inflammatory bowel disease (IBD) prescribed azathioprine (AZA)/mercaptopurine (MP) demonstrate a skewed drug metabolism with low thioguanine nucleotides (TGN) and unexpectedly high methylmercaptopurine (MeMP) levels. This predicts a lack of treatment efficacy and excess adverse events; however studies on the effect of thiopurine hypermethylation (TH) in adult ...
Chauvin Armelle A Assistance Publique-Hôpitaux de Paris (APHP), Paris Est Creteil University (UPEC), Henri Mondor Hospital, Department of Gastroenterology, Creteil, - - 2014
Infliximab withdrawal in patients with Crohn's disease on concomitant antimetabolite therapy is considered to be superior if obtained after a maintenance therapy period compared to induction alone. We retrospectively analyzed the outcome of Crohn's disease patients treated with infliximab and an antimetabolite after infliximab was withdrawn using induction alone or ...
Nardone Gerardo G Department of Clinical Medicine and Surgery, Gastroenterology Unit, University "Federico II", Naples, Italy. Electronic address: - - 2014
Gastrointestinal angiodysplasias are an important cause of bleeding difficult to manage especially in older patients. To retrospectively evaluate the long-term efficacy of long acting release-octreotide in controlling angiodysplasia bleeding. 98 patients with a history of bleeding due to gastrointestinal angiodysplasias lasting over 2 years were retrospectively selected among those treated ...
Hata Masayuki M Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, - - 2014
To investigate the 2-year outcomes of photodynamic therapy (PDT) combined with intravitreal injections of ranibizumab for polypoidal choroidal vasculopathy (PCV). Ninety-five eyes with subfoveal PCV treated with combined therapy were followed for ≥24 months. The association between visual outcomes and single nucleotide polymorphisms in ARMS2 A69S and CFH I62V genes were ...
Vorhies Erika E EE Division of Pediatric Cardiology, Department of Pediatrics, University of Calgary, Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, AB, T3B 6A8, Canada, - - 2014
Inhaled nitric oxide (iNO) is considered standard therapy for pediatric postcardiac surgical pulmonary hypertension (PH). Limited data suggest that inhaled iloprost (inIlo), an aerosolized prostacyclin, may be a feasible and more affordable therapeutic alternative. The goal of this study was to determine if significant hemodynamic change or adverse events would ...
Giehl Kathrin A KA Department of Dermatology and Allergology Ludwig-Maximilian University Munich Frauenlobstr. 9-11 80337 Munich, - - 2014
Background: Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) with red light is well established for actinic keratosis (AK). Differences have been observed concerning pain and efficacy rates with different red light sources. Objectives: To compare pain scores, short- and long-term efficacy rates of PDT of multiple AKs when employing different ...
Chua Horng-Ruey HR Department of Intensive Care, Austin Hospital, Melbourne, Australia; Division of Nephrology, Department of Medicine, National University Hospital, National University Health System, - - 2014
The risk of catheter-related infection or bacteremia, with initial and extended use of femoral versus nonfemoral sites for double-lumen vascular catheters (DLVCs) during continuous renal replacement therapy (CRRT), is unclear. Retrospective observational cohort study. Critically ill patients on CRRT in a combined intensive care unit of a tertiary institution. Femoral ...
Verstraelen F U FU Viecuri Medical Centre, Tegelseweg 210, 5912 BL, Venlo, The Netherlands, - - 2014
There are several treatment options for calcifying tendinitis of the shoulder. The next step treatment after conservative treatment fails is still a matter of dispute. Extracorporeal shock wave therapy (ESWT) has been shown to be a good alternative to surgery, but the best treatment intensity remains unknown. High-energy ESWT is ...
Takebayashi Takashi T Department of Rehabilitation, The Hospital of Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. Electronic address: - - 2014
Botulinum toxin type A (BtxA) injection, constraint-induced movement therapy (CIMT) and robotic therapy (RT) each represent promising approaches to enhance arm motor recovery after stroke. To provide more effective treatment for a 50-year-old man with severe left spastic hemiparesis, we attempted to facilitate CIMT with adaptive approaches to extend the ...
Galland-Girodet Sigolène S Department of Radiation Oncology, Massachusetts General Hospital, Boston, - - 2014
To present long-term outcomes of a prospective feasibility trial using either protons or 3-dimensional conformal photon-based (accelerated partial-breast irradiation [APBI]) techniques. From October 2003 to April 2006, 98 evaluable patients with stage I breast cancer were treated with APBI (32 Gy in 8 fractions given twice daily) on a prospective clinical trial: ...
Turner DeAnna W DW University Health System, San Antonio, TX, USA University of the Incarnate Word Feik School of Pharmacy, San Antonio, TX, - - 2014
During respiratory and metabolic acidosis, the vasoconstrictive effects of epinephrine may be blunted, whereas the response to vasopressin remains unchanged. The impact of this effect during advanced cardiac life support (ACLS) remains unclear. Determine if vasopressin therapy in combination with epinephrine was associated with improved outcomes in patients with cardiac ...
Tagami Takashi T Department of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan, - - 2014
Although prophylactic triple-H therapy has been used in a number of institutions globally to prevent delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH), limited evidence is available for the effectiveness of triple-H therapy on hemodynamic variables. Recent studies have suggested an association between low global end-diastolic volume index (GEDI), measured ...
De Caridi Giovanni G Cardiovascular and Thoracic Department, 'Policlinico G. Martino' Hospital, University of Messina, Messina, - - 2014
Vacuum-assisted closure (VAC) therapy is a new emerging non-invasive system in wound care, which speeds up wound healing by causing vacuum, improving tissue perfusion and suctioning the exudates, and facilitating the removal of bacteria from the wound. The application of sub-atmospheric pressure on the lesions seems to alter the cytoskeleton ...
Mastropasqua Rodolfo R Ophthalmology Unit Department of Neurological Neuropsychological Morphological and Movement Sciences, University of Verona, Verona, - - 2014
To analyze, using in vivo laser scanning confocal microscopy (LSCM), the conjunctival features in glaucomatous patients receiving prostaglandin analogues (PGA). Eighty eyes of 80 consecutive glaucomatous patients naive for therapy were enrolled; 30 eyes of 30 healthy subjects served as a control. Patients were randomized to: preservative-free (PF) and preserved ...
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