Search Results
Results 251 - 300 of 4749
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Hernigou Philippe P Orthopaedic Surgery, Hopital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France, - - 2014
The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were correlated with the number of MSCs received at the tendon-to-bone interface. Forty-five patients in the ...
Lee Hye-Suk HS Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, South - - 2014
Objective: The aim of this study was to investigate the prevalence and causes of early discontinuation and non-adherence to upfront and extended adjuvant letrozole therapy in breast cancer patients. Methods: Adherence was assessed using medical charts and longitudinal pharmacy records of 609 patients who initiated adjuvant letrozole between January 2002 ...
Vern-Gross Tamara Z TZ Department of Radiation Oncology, University of Florida Proton Therapy Institute, Jacksonville, Florida (T.Z.V.-G.); Department of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee (J.E.S.); Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee (A.B.); Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee (S.W., X.X.); Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee - - 2014
A phase II trial of conformal radiotherapy (CRT) for pediatric high-grade glioma (HGG) was performed to evaluate disease control and late effects. Between July 1997 and January 2003, 34 pediatric patients (median age, 13.2 ± 6.7 years) with HGG were enrolled on an International Commission on Radiation Units and Measurements ...
Andrijević Derk B B University Clinical Centre 'Sestre milosrdnice', University Department of Ophthalmology, Zagreb, - - 2014
PurposeTo report a case series of three patients with bilateral uveal effusion syndrome (UES), treated conservatively with oral carbonic anhydrase inhibitors and topical prostaglandin analogues (PAs).MethodsThree patients with bilateral UES were treated with the same initial therapy. Topical PA latanoprost 0.005% and acetazolamide 250 mg were administered in order to reduce ...
Kim Hae Rim HR Department of Internal Medicine, Korea University College of - - 2014
This study compared the antiviral efficacy of telbivudine (TBV) and entecavir (ETV) in hepatitis B virus (HBV)-related liver cirrhosis. ETV is effective in the treatment of chronic HBV infections, even in patients with underlying cirrhosis. However, there is little information on the effect of TBV in chronic hepatitis B patients ...
Haak C S CS Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Photodynamic therapy (PDT) is approved for selected nodular basal cell carcinomas (nBCC) but efficacy is reduced for large and thick tumours. Ablative fractional lasers (AFXL) facilitate uptake of methyl aminolevulinate (MAL) and may thus improve PDT outcome. Evaluate efficacy and safety of AFXL-mediated PDT (AFXL-PDT) compared to conventional PDT (PDT) ...
Cholongitas Evangelos E 4th Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, - - 2014
New nucleos(t)ide agents (NAs) [entecavir (ETV) and tenofovir (TDF)] have made hepatitis B immunoglobulin (HBIG)-sparing protocols an attractive approach against hepatitis B virus (HBV) recurrence after liver transplantation (LT). Twenty eight patients transplanted for HBV cirrhosis in our centre were prospectively evaluated. After LT, each patient received HBIG (1,000IU IM/day ...
Kane Katherine K Division of Vascular Surgery, Baylor University Medical Center, Dallas, - - 2014
Endovenous laser ablation (EVLA) of the saphenous vein has become one of the preferred treatments for treating saphenous vein reflux that has resulted in symptomatic lower extremity venous insufficiency or varicose veins. This procedure was noted during initial reports to have a low incidence of postoperative thrombosis of the femoral ...
Wang Raymond Y RY Division of Metabolic Disorders, CHOC Children's, Orange, CA, USA. Electronic address: - - 2014
Treatment with intravenous enzyme replacement therapy and hematopoietic stem cell transplantation for mucopolysaccharidosis (MPS) type I does not address joint disease, resulting in persistent orthopedic complications and impaired quality of life. A proof-of-concept study was conducted to determine the safety, tolerability, and efficacy of intra-articular recombinant human iduronidase (IA-rhIDUA) enzyme ...
Kolek Matthew J MJ Department of Medicine, Vanderbilt University, Nashville, - - 2014
For many patients with atrial fibrillation, ventricular rate control with atrioventricular (AV) nodal blockers is considered first-line therapy, although response to treatment is highly variable. Using an extreme phenotype of failure of rate control necessitating AV nodal ablation and pacemaker implantation, we conducted a genome-wide association study (GWAS) to identify ...
Scott Dgi D Norfolk and Norwich University Hospital , Norwich , - - 2014
Objectives: To retrospectively evaluate continuation rates in patients with rheumatoid arthritis (RA) who failed to respond to or tolerate oral methotrexate (MTX) and were subsequently switched to subcutaneous MTX (SC MTX) in routine clinical practice. Method: We conducted a retrospective review of all patients with RA who had been prescribed ...
Brown Ashley L AL Department of Dermatology, University of Texas Southwestern-Austin, Austin, Texas, - - 2014
Primary focal hyperhidrosis is a common condition that negatively impacts quality of life for many pediatric patients and can be challenging to treat. Standard treatments for hyperhidrosis can be used with success in many patients, and newer therapies and techniques offer options that have demonstrated efficacy and safety. This review ...
Bose Abhishek A Cardiac Arrhythmia Service, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, - - 2014
Cardiac valve surgery (CVS) has been implicated as a potential barrier to optimal response after cardiac resynchronization therapy (CRT) though prospective data regarding outcome remains limited. We sought to determine CRT response in patients with a prior history of CVS. We performed a retrospective analysis of a prospectively acquired cohort ...
Kukreja Kamlesh U KU Departments of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229. Electronic address: - - 2014
To evaluate the technical feasibility and safety of percutaneous endovascular thrombolysis for extremity deep venous thrombosis (DVT) in children < 24 months old. A retrospective chart review of a clinical and imaging database was performed for pediatric patients who underwent endovascular therapy for DVT between January 2010 and July 2013. ...
Boucher Helen W HW From the Division of Infectious Diseases and Geographic Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston (H.W.B.); the Department of Microbiology, Leeds Teaching Hospital and University of Leeds, Old Medical School, Leeds, United Kingdom (M.W.); Talbot Advisors, Anna Maria, FL (G.H.T.); Durata Therapeutics, Branford, CT (S.P., M.W.D.); and InClin, San Mateo, CA - - 2014
Dalbavancin, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. DISCOVER 1 and DISCOVER 2 were identically designed noninferiority trials of dalbavancin for the treatment of acute bacterial skin and skin-structure infection. We randomly assigned patients to receive dalbavancin intravenously ...
Archdeacon Michael T MT Department of Orthopaedic Surgery, University of Cincinnati, PO Box 670212, Cincinnati, OH, 45267-0212, USA, - - 2014
Prophylactic approaches to prevent heterotopic ossification after acetabular fracture surgery have included indomethacin and/or single-dose external beam radiation therapy administered after surgery. Although preoperative radiation has been used for heterotopic ossification prophylaxis in the THA population, to our knowledge, no studies have compared preoperative and postoperative radiation therapy in the ...
Yap Sing-Chien SC Department of Cardiology, Erasmus Medical Center, Rotterdam, The - - 2014
It is not clear whether patients who received an implantable cardioverter-defibrillator (ICD) for primary prevention should undergo device replacement if they never experienced an appropriate ICD therapy during the first generator longevity. This study evaluated the incidence and predictors of appropriate ICD therapy after device replacement in this specific population. ...
Al-Khatib Sana M - - 2014
The comparative effectiveness of treatments for atrial fibrillation (AF) is uncertain. To evaluate the comparative effectiveness of rate- and rhythm-control therapies. English-language studies in PubMed, EMBASE, and the Cochrane Database of Systematic Reviews between January 2000 and November 2013. Two reviewers independently screened citations to identify comparative studies that assessed ...
Palma Juan Carlos JC a Adjunct Professor, Department of Orthodontics, Faculty of Odontology, University Complutense, Madrid, - - 2014
Objective: To analyze the long-term stability of rapid maxillary expansion (RME) and protraction from chincup therapy in girls with Class III malocclusion. Materials and Methods: Twenty-two girls (mean age  =  9.1 ± 0.6 years) with Class III malocclusion were treated with combined RME and protraction from a chincup, followed by fixed ...
Xin Wei W Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, - - 2014
The role of B-type natriuretic peptide (BNP) in the management of patients with chronic heart failure (CHF) was uncertain. The aim of this meta-analysis was to comprehensively evaluate the effect of BNP-guided therapy in CHF. Relevant randomized controlled trials were identified by searching of Pubmed, Embase and the Cochrane Library ...
Washam Jeffrey B JB Duke Heart Center, Duke University Medical Center, DUMC 3943, Durham, NC, 27710, USA, - - 2014
Currently, there is a lack of consensus among guidelines for the postdischarge treatment of patients presenting with acute coronary syndrome (ACS) who have a long-term indication for anticoagulation. We conducted a systematic review comparing the safety and effectiveness of dual antiplatelet therapy (DAPT) and triple therapy (TT; defined as DAPT ...
Srivastava Rajeshwar N RN Department of Orthopaedic Surgery, King George's Medical University (KGMU), Lucknow, - - 2014
The conventional methods of treatment of pressure ulcers (PUs) by serial debridement and daily dressings require prolonged hospitalisation, associated with considerable morbidity. There is, however, recent evidence to suggest that negative pressure wound therapy (NPWT) accelerates healing. The commercial devices for NPWT are costly, cumbersome, and electricity dependent. We compared ...
Jayant Kumar K Department of Urology, Sudha Hospital and Medical Research Centre, Kota, Rajasthan, - - 2014
To compare the efficacy of tamsulosin versus tamsulosin plus tadalafil as medical expulsive therapy for lower ureteric stones. Between January 2013 and December 2013, 244 patients presenting with distal ureteric stones (size 5-10 mm) were randomized equally to tamsulosin (group A) or tamsulosin plus tadalafil (group B). Therapy was given for ...
McCarty Morgan M Dermatology Residency Program, Saint Joseph Mercy Health System, Ann Arbor, - - 2014
The twin goals of long-term disease control and minimizing toxicities related to immunosuppression necessitate efforts to find effective steroid-sparing agents in the management of patients with autoimmune bullous diseases. Pemphigus especially requires a long view, because the disease can persist throughout a patient's lifetime, yet few clinical trial reports exist ...
Rodríguez-Pardo D D Infectious Diseases Division, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Catheter-related bacteraemia (CRB) is a cause of death in hospitalized patients, and parenteral nutrition (PN) is a risk factor. We aim to describe the prognosis of PN-CRB and the impact of catheter extraction within 48h from bacteraemia. All consecutive hospitalized adult patients with CRB (2007-2012) were prospectively enrolled. Factors associated ...
Smith Matthew R MR Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, - - 2014
Endoscopic human thrombin injection appears to be a technically simple and efficacious alternative to tissue adhesives with fewer complications; however, data remain limited. We analysed our experience using endoscopic human thrombin injection for gastric varices in a tertiary referral liver unit. Thirty patients received thrombin injection for gastric varices between ...
Battaglia Alex A *Department of Otolaryngology, Head and Neck Surgery, Southern California Permanente Medical Group, San Diego; and †Department of Research and Evaluation, Regional Offices of Southern California Permanente Medical Group, Pasadena, California, - - 2014
To compare combination therapy (high-dose prednisone taper (HDPT) + intratympanic dexamethasone (IT-Dex)) hearing recovery results in ISSNHL patients with those treated with HDPT alone. Prospective, multicentered trial. Tertiary referral center. Eighty ISSNHL patients with class C or D hearing. Eighty qualifying patients were treated with IT-Dex (10 mg/ml) every week ...
Ruddy Kathryn J KJ Department of Oncology, Mayo Clinic, Rochester, MN. Electronic address: - - 2014
In premenopausal women with breast cancer, standard adjuvant endocrine therapy has been 5 years of tamoxifen. This study sought to investigate the safety and feasibility of treating patients who remain premenopausal after adjuvant tamoxifen with gonadotropin-releasing hormone agonist (GnRH-a) concurrent with an aromatase inhibitor, mimicking the strategy that has proven ...
Razavi Mahmood K MK St Joseph Hospital Heart & Vascular Center, 1140 West La Veta Ave, Suite 850, Orange, CA, 92868, USA, - - 2014
The basic treatment of deep vein thrombosis (DVT) over the past several decades has consisted of anticoagulation only, with inferior vena cava filtration for those who either failed or could not tolerate anticoagulation. Until recently no randomized trials had studied the efficacy of thrombolysis in DVT despite advances in techniques ...
Hanson Neil A NA From the *Department of Anesthesiology, Virginia Mason Medical Center; †Department of Anesthesiology, Physicians Anesthesia Service, Seattle, Washington; and ‡Axio Research, Seattle, - - 2014
Adductor canal blocks have shown promise in reducing postoperative pain in total knee arthroplasty patients. No randomized, controlled studies, however, evaluate the opioid-sparing benefits of a continuous 0.2% ropivacaine infusion at the adductor canal. We hypothesized that a continuous adductor canal block would decrease postoperative opioid consumption. Eighty subjects presenting ...
Mancini Nicasio N Laboratory of Microbiology and Virology, University "Vita-Salute" San Raffaele, Milan, - - 2014
We evaluated the costs and clinical outcomes of episodes of suspected sepsis in hematological patients. A propensity score-matched study was planned, comparing a retrospective cohort managed with standard assays and a prospective cohort managed with the addition of a molecular assay. Diagnostic procedures and therapy were considered as costs variables. ...
Grauhan Onnen O Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, - - 2014
Skin breakdown and infiltration of skin flora are key causative elements in poststernotomy wound infections. We hypothesised that surgical incision management (SIM) using negative pressure wound therapy over closed surgical incisions for 6-7 days would reduce wound infections in a comprehensive poststernotomy patient population. 'All comers' undergoing median sternotomy at our ...
Toker Serdar S Meram Faculty of Medicine, Department of Orthopaedic Surgery, Konya Selcuk University, Konya, - - 2014
Nonadherence to postoperative therapy protocols can adversely affect the outcome after flexor tendon surgery. In this study, we hypothesize that patients with partial or no insurance coverage for their aftercare are less likely to attend postoperative therapy sessions and have a higher incidence of a poorer outcome than those who ...
Hackshaw Michelle D MD 5 Crescent Dr., Philadelphia, PA 19112. - - 2014
Pazopanib is an oral tyrosine kinase inhibitor with demonstrated efficacy and tolerability in patients with advanced renal cell carcinoma (RCC). To examine pazopanib persistence and compliance (adherence) and other drug utilization patterns in both treatment-naïve (first-line) patients and those previously treated with RCC therapy in the real-world setting. Key factors ...
Brain Matthew J MJ School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. - - 2014
The effectiveness of continuous renal replacement therapy (CRRT) increases when unplanned circuit failure is prevented. Adequate anticoagulation is an important component. Although heparin is the predominating anticoagulant, calcium chelation with citrate is an alternative, but systemic calcium monitoring and supplementation increase the complexity of CRRT. We assessed efficacy and safety ...
Crosswell Ashley A Department of Intensive Care, The Alfred, Melbourne, VIC, Australia. - - 2014
To determine the influence of vascular access site on continuous renal replacement therapy (CRRT) filter survival. Retrospective study of the records of patients who received CRRT in The Alfred intensive care unit from June 2011 to May 2012. Filter run time. We matched filter run time to site and type ...
Moulakakis Konstantinos G KG Department of Vascular Surgery, Athens University Medical School, Attikon University Hospital, Athens, - - 2014
Purpose : To review the published outcomes of aortic endograft infection treated with preservation of the stent-graft. Methods : An extensive electronic health database search was undertaken to identify all articles published up to May 2013 that reported endograft infection after endovascular aneurysm repair (EVAR) in which treatment included preservation ...
Nishikawa Hiroki H Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan - - 2014
Aim: To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. Patients and Methods: A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: patients treated with non-transplant ...
Shi Xuehui X Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Science Key Labratory, Beijing 100730, - - 2014
Photodynamic therapy (PDT) has been recommended as a main treatment for idiopathic choroidal neovascularization (I-CNV). But the visual results of PDT were inconsistent and variable, and PDT may bring severe damage to the retinal pigment epithelium and choriocapillaries. In recent years, intravitreal ranibizumab therapy, showing favorable visual outcomes, has developed ...
Yang Jeong Hoon JH Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South - - 2014
This study sought to investigate the association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). Limited data are available on the efficacy of beta-blocker therapy for secondary prevention in STEMI patients. Between November 1, 2005 and September ...
Oh Dong Hyun - - 2014
Recent prospective studies have shown that the sequential therapy has not achieved the target Helicobacter pylori eradication rate of > 80% in Korea. The aim of this study was to therefore assess the efficacy of the hybrid therapy as a first-line treatment for H. pylori eradication in a prospective trial. From ...
Reddy S V Krishna SV Department of Urology, Narayana Medical College and Hospital, Nellore, - - 2014
To study the effects of long-term treatment with potassium magnesium citrate and vitamin B-6 prophylaxis (Urikind-KM6; 1,100-mg potassium citrate, 375-mg magnesium citrate, and 20-mg pyridoxine hydrochloride/5 mL) every 8 hours over 3 years. A total of 247 patients with recurrent idiopathic hypocitraturia with or without hyperuricosuria and randomized controls were ...
Tofuku Katsuhiro K Department of Orthopaedic Surgery, Imakiire General Hospital, Kagoshima, - - 2014
A retrospective study. The purpose of this study was to evaluate outcomes in patients with pyogenic spondylitis accompanied by iliopsoas abscess who were treated by percutaneous drainage combined with hyperbaric oxygen (HBO) therapy. To the best of our knowledge, there have been no previous reports of the use of percutaneous ...
Alfaqeeh S A - - 2014
Background: Gingival Crevicular Fluid (GCF) changes occur during orthodontic tooth movement and this could serve as a potential indicator to the response to active treatment. Aim: The objective of the study is to assess the changes in the GCF volume and the levels of Alkaline Phosphatase (ALP) during early phase ...
Farouk Ridzuan R Department of Surgery, National University Hospital, - - 2014
To estimate the risk of recurrent fissure in ano after sphincter preserving treatments. A retrospective case note review, combined with a telephone survey was conducted for all patients treated for a chronic anal fissure between 1998 and 2008. Six hundred and twelve patients (303 women: mean age, 39 years; range, ...
Imperatore Vittorio V Department of Urology, Buon Consiglio Fatebenefratelli Hospital, Naples. - - 2014
Objectives: To compare the efficacy and safety of tamsulosin and silodosin in the context of medical expulsive therapy (MET) of distal ureteric stones. Patients and methods: Observational data were collected retrospectively from patients who received silodosin (N = 50) or tamsulosin (N = 50) as MET from January 2012 to ...
Park Seong Doo SD Graduate School of Physical Therapy, Daejeon University, Daejeon, - - 2014
The purpose of this study is to investigate that effect of action observation training (AOT) on knee joint function and balance in total knee replacement (TKR) patients. The subjects consisted of eighteen post-TKR patients. All participants underwent conventional physical therapy. In addition, patients in the AOT group (n= 9) were ...
Santana Rafael Santos RS Universidade de - - 2014
To evaluate the improper use of antimicrobials during the postoperative period and its economic impact. We conducted a prospective cohort study by collecting data from medical records of 237 patients operated on between 01/11/08 and 31/12/08. from the 237 patients with the information collected, 217 (91.56%) received antimicrobials. During the ...
Suzuki Satoshi S 1Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia. 2Australian and New Zealand Intensive Care Research Centre, Melbourne, VIC, - - 2014
To assess the feasibility and safety of a conservative approach to oxygen therapy in mechanically ventilated ICU patients. Pilot prospective before-and-after study. A 22-bed multidisciplinary ICU of a tertiary care hospital in Australia. A total of 105 adult (18 years old or older) patients required mechanical ventilation for more than ...
Ray Kathryn J KJ F. I. Proctor Foundation, University of California, San Francisco2Department of Epidemiology and Biostatistics, University of California, San - - 2014
Scarring from bacterial keratitis remains a leading cause of visual loss. To determine whether topical corticosteroids are beneficial as an adjunctive therapy for bacterial keratitis if given early in the course of infection. The Steroids for Corneal Ulcers Trial (SCUT) was a randomized, double-masked, placebo-controlled trial that overall found no ...
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