Search Results
Results 201 - 250 of 4643
< 1 2 3 4 5 6 7 8 9 10 >
Alfaqeeh S A - - 2014
Background: Gingival Crevicular Fluid (GCF) changes occur during orthodontic tooth movement and this could serve as a potential indicator to the response to active treatment. Aim: The objective of the study is to assess the changes in the GCF volume and the levels of Alkaline Phosphatase (ALP) during early phase ...
Farouk Ridzuan R Department of Surgery, National University Hospital, - - 2014
To estimate the risk of recurrent fissure in ano after sphincter preserving treatments. A retrospective case note review, combined with a telephone survey was conducted for all patients treated for a chronic anal fissure between 1998 and 2008. Six hundred and twelve patients (303 women: mean age, 39 years; range, ...
Imperatore Vittorio V Department of Urology, Buon Consiglio Fatebenefratelli Hospital, Naples. - - 2014
Objectives: To compare the efficacy and safety of tamsulosin and silodosin in the context of medical expulsive therapy (MET) of distal ureteric stones. Patients and methods: Observational data were collected retrospectively from patients who received silodosin (N = 50) or tamsulosin (N = 50) as MET from January 2012 to ...
Patel Vc V Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, - - 2014
Rifaximin-α is a non-absorbable antibiotic increasingly being used for the secondary prevention of recurrent overt hepatic encephalopathy (HE) in the UK. The therapeutic mechanism of rifaximin has yet to be elucidated, with reduction in gut ammonia production postulated. We undertook a UK multi-centre retrospective audit of patients receiving rifaximin therapy ...
Harrow P P Department of Gastroenterology, Queen's Hospital, Romford, - - 2014
Leucocytapheresis, the extracorporeal removal of leucocytes from patient's blood, has conflicting evidence of benefit in ulcerative colitis (UC). Numerous studies have recorded short term clinical remission rates while few have examined the long term end-points of colectomy, death and steroid free remission. Queen's Hospital, Romford is one of the largest ...
Clegg F F Gastroenterology, Aberdeen Royal Infirmary, Aberdeen, - - 2014
Hepatocellular cancer (HCC) is a recognised complication of liver cirrhosis.(1) The cause of liver cirrhosis is varied, but the prevalence of certain conditions like non-alcoholic fatty liver disease (NAFLD) is rising.(2) This study aimed to identify the time trends of HCC over the last 10 years focusing on the aetiopathology ...
Holleran G G Department of Clinical Medicine, Trinity College Dublin, Tallaght, IrelandGastroenterology, Tallaght Hospital, Tallaght, - - 2014
Angiodysplasias account for up to 50% of causes of small bowel bleeding and due to their relative inaccessibility and the intermittent nature of their bleeding they present a particular therapeutic challenge. Endoscopic ablation with APC is the most efficacious at reducing re-bleeding rates, however; its effect is short-lived and not ...
Steed H H Gastroenterology, University Hospital North Staffordshire, Stoke-on-Trent, - - 2014
Prescription of a-TNF therapy in UC in the UK is limited to acute severe colitis by NICE. Increasingly physicians are under pressure from patients to offer an alternative to the traditional limited therapeutic options and this has resulted in the drug being used in the subacute setting, as it is ...
Kennedy Na N GI Unit, Western General Hospital, Edinburgh, - - 2014
Infliximab and adalimumab have established roles in IBD therapy. NICE and SMC guidelines mandate reassessment of disease activity after 12 months. Therapy should ordinarily be discontinued where clinical remission and mucosal healing has been achieved. However, there are presently few data about outcomes of anti-TNF withdrawal. We conducted a retrospective ...
Churchhouse Am A GI Unit, Western General Hospital, Edinburgh, - - 2014
Patients with severe Ulcerative Colitis (UC) are commonly identified using the Truelove and Witts(1) criteria on presentation. The Travis(2) and Ho(3) scores are subsequently used to identify patients with severe UC who are at high risk of failing medical therapy and needing second line therapy or colectomy. To date there ...
Russo E E Medicine, Imperial College London, - - 2014
A common therapeutic strategy in events of failure of the first-line anti-TNFα biologic in Crohn's Disease (CD) is to switch to another biologic agent from the same class. There is a significant body of evidence to support using adalimumab (ADA) as second-line therapy following infliximab (IFX) intolerance or loss of ...
Aggarwal D D Gastroenterology, Pennine Acute Hospitals NHS Trust, Manchester, - - 2014
Patients with Ulcerative Colitis [UC] may be exposed to ionising radiation for evaluation of disease with inherent risks from protracted exposure. Meanwhile, bolder definitions of disease control with evolving treatment paradigms have led to earlier introduction of biological therapy. Our aim was to compare the effective radiation dose prior to ...
Blaker Pa P Gastroenterology, Guys and St Thomas Hospitals' NHS Foundation Trust, London, - - 2014
15% of patients with inflammatory bowel disease (IBD) prescribed azathioprine (AZA)/mercaptopurine (MP) demonstrate a skewed drug metabolism with low thioguanine nucleotides (TGN) and unexpectedly high methylmercaptopurine (MeMP) levels. This predicts a lack of treatment efficacy and excess adverse events; however studies on the effect of thiopurine hypermethylation (TH) in adult ...
Sood R R Leeds Gastroenterology Institute, St James University Hospital, Leeds, - - 2014
Azathioprine (AZA) is an established treatment for ulcerative colitis (UC). However, controversy exists regarding its efficacy in inducing and maintaining clinical remission, particularly with the advent of biologics which, unlike AZA, have been tested in large, rigorously designed randomised controlled trials. We studied the effectiveness of AZA as second-line therapy ...
Johnson He H Gastroenterology, Royal Bournemouth Hospital, Bournemouth, - - 2014
Despite the advancement and introduction of new biological therapies, thiopurines remain effective treatment options for the maintenance of remission for both ulcerative colitis (UC) and Crohn's disease (CD). Once tolerated and therapeutic, thiopurines have many advantages over biologics for long-term maintenance therapy. However, it has been documented that intolerance and ...
Patel J J Watford General Hospital, Watford, - - 2014
Endoclot™ is a non-toxic topical haemostatic powder consisting of absorbable modified polymers. We previously described our early experience using Endoclot™ as an adjunct haemostatic endoscopic therapy in 6 patients undergoing elective/emergency upper or lower gastrointestinal (GI) endoscopy.(1) We now present the largest case series to date describing the use of ...
Nardone Gerardo G Department of Clinical Medicine and Surgery, Gastroenterology Unit, University "Federico II", Naples, Italy. Electronic address: - - 2014
Gastrointestinal angiodysplasias are an important cause of bleeding difficult to manage especially in older patients. To retrospectively evaluate the long-term efficacy of long acting release-octreotide in controlling angiodysplasia bleeding. 98 patients with a history of bleeding due to gastrointestinal angiodysplasias lasting over 2 years were retrospectively selected among those treated ...
Chauvin Armelle A Assistance Publique-Hôpitaux de Paris (APHP), Paris Est Creteil University (UPEC), Henri Mondor Hospital, Department of Gastroenterology, Creteil, - - 2014
Infliximab withdrawal in patients with Crohn's disease on concomitant antimetabolite therapy is considered to be superior if obtained after a maintenance therapy period compared to induction alone. We retrospectively analyzed the outcome of Crohn's disease patients treated with infliximab and an antimetabolite after infliximab was withdrawn using induction alone or ...
Hata Masayuki M Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, - - 2014
To investigate the 2-year outcomes of photodynamic therapy (PDT) combined with intravitreal injections of ranibizumab for polypoidal choroidal vasculopathy (PCV). Ninety-five eyes with subfoveal PCV treated with combined therapy were followed for ≥24 months. The association between visual outcomes and single nucleotide polymorphisms in ARMS2 A69S and CFH I62V genes were ...
Verstraelen F U FU Viecuri Medical Centre, Tegelseweg 210, 5912 BL, Venlo, The Netherlands, - - 2014
There are several treatment options for calcifying tendinitis of the shoulder. The next step treatment after conservative treatment fails is still a matter of dispute. Extracorporeal shock wave therapy (ESWT) has been shown to be a good alternative to surgery, but the best treatment intensity remains unknown. High-energy ESWT is ...
Vorhies Erika E EE Division of Pediatric Cardiology, Department of Pediatrics, University of Calgary, Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, AB, T3B 6A8, Canada, - - 2014
Inhaled nitric oxide (iNO) is considered standard therapy for pediatric postcardiac surgical pulmonary hypertension (PH). Limited data suggest that inhaled iloprost (inIlo), an aerosolized prostacyclin, may be a feasible and more affordable therapeutic alternative. The goal of this study was to determine if significant hemodynamic change or adverse events would ...
Giehl Kathrin A KA Department of Dermatology and Allergology Ludwig-Maximilian University Munich Frauenlobstr. 9-11 80337 Munich, - - 2014
Background: Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) with red light is well established for actinic keratosis (AK). Differences have been observed concerning pain and efficacy rates with different red light sources. Objectives: To compare pain scores, short- and long-term efficacy rates of PDT of multiple AKs when employing different ...
Chua Horng-Ruey HR Department of Intensive Care, Austin Hospital, Melbourne, Australia; Division of Nephrology, Department of Medicine, National University Hospital, National University Health System, - - 2014
The risk of catheter-related infection or bacteremia, with initial and extended use of femoral versus nonfemoral sites for double-lumen vascular catheters (DLVCs) during continuous renal replacement therapy (CRRT), is unclear. Retrospective observational cohort study. Critically ill patients on CRRT in a combined intensive care unit of a tertiary institution. Femoral ...
Mastropasqua Rodolfo R Ophthalmology Unit Department of Neurological Neuropsychological Morphological and Movement Sciences, University of Verona, Verona, - - 2014
To analyze, using in vivo laser scanning confocal microscopy (LSCM), the conjunctival features in glaucomatous patients receiving prostaglandin analogues (PGA). Eighty eyes of 80 consecutive glaucomatous patients naive for therapy were enrolled; 30 eyes of 30 healthy subjects served as a control. Patients were randomized to: preservative-free (PF) and preserved ...
Tagami Takashi T Department of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan, - - 2014
Although prophylactic triple-H therapy has been used in a number of institutions globally to prevent delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH), limited evidence is available for the effectiveness of triple-H therapy on hemodynamic variables. Recent studies have suggested an association between low global end-diastolic volume index (GEDI), measured ...
De Caridi Giovanni G Cardiovascular and Thoracic Department, 'Policlinico G. Martino' Hospital, University of Messina, Messina, - - 2014
Vacuum-assisted closure (VAC) therapy is a new emerging non-invasive system in wound care, which speeds up wound healing by causing vacuum, improving tissue perfusion and suctioning the exudates, and facilitating the removal of bacteria from the wound. The application of sub-atmospheric pressure on the lesions seems to alter the cytoskeleton ...
Turner DeAnna W DW University Health System, San Antonio, TX, USA University of the Incarnate Word Feik School of Pharmacy, San Antonio, TX, - - 2014
During respiratory and metabolic acidosis, the vasoconstrictive effects of epinephrine may be blunted, whereas the response to vasopressin remains unchanged. The impact of this effect during advanced cardiac life support (ACLS) remains unclear. Determine if vasopressin therapy in combination with epinephrine was associated with improved outcomes in patients with cardiac ...
Takebayashi Takashi T Department of Rehabilitation, The Hospital of Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. Electronic address: - - 2014
Botulinum toxin type A (BtxA) injection, constraint-induced movement therapy (CIMT) and robotic therapy (RT) each represent promising approaches to enhance arm motor recovery after stroke. To provide more effective treatment for a 50-year-old man with severe left spastic hemiparesis, we attempted to facilitate CIMT with adaptive approaches to extend the ...
Galland-Girodet Sigolène S Department of Radiation Oncology, Massachusetts General Hospital, Boston, - - 2014
To present long-term outcomes of a prospective feasibility trial using either protons or 3-dimensional conformal photon-based (accelerated partial-breast irradiation [APBI]) techniques. From October 2003 to April 2006, 98 evaluable patients with stage I breast cancer were treated with APBI (32 Gy in 8 fractions given twice daily) on a prospective clinical trial: ...
Wang Q Q Shandong Provincial Hospital affiliated to Shandong University, Jinan, - - 2014
Hypogonadotropic hypogonadism (HH) is common in pituitary stalk interruption (PSI) patients. However, the optimal timing and effective regimen in the management of the pituitary-gonadal axis deficiency is still controversial. This study involved a retrospective review of 38 male patients with HH resulting from PSI. The HH patients were subdivided according ...
Cutro Scott R SR Division of Infectious Diseases, New York University School of Medicine, New York, New York, USAThe Southeast Permanente Medical Group, Atlanta, Georgia, USA - - 2014
Piperacillin-tazobactam (PTZ) is frequently used as both empiric and targeted therapy for Gram-negative sepsis. Time-dependent killing properties of PTZ support the use of extended-infusion (EI) dosing, however studies have shown inconsistent benefits of EI PTZ on clinical outcomes. We performed a retrospective cohort study of adult patients who received EI ...
Garanito Marlene Pereira MP Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Electronic address: - - 2014
to evaluate the outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine as first-line treatment at this institution. retrospective analysis of 26 pediatric patients with aplastic anemia, treated between 1996 and 2011 with rabbit antithymocyte globulin plus cyclosporine. the overall response rate at six ...
Sabino Flávio D FD Department of Abdominal and Pelvic Surgery, National Cancer Institute, Rio de Janeiro, Brazil; Department of General Surgery, Federal Hospital of Rio de Janeiro State Civil Servers, Rio de Janeiro, Brazil. Electronic address: - - 2014
The administration of intraperitoneal (IP) 5-fluorouracil (5-FU) during the early postoperative period after cytoreductive surgery can decrease local cancer recurrence but may also cause impairment of the anastomotic healing. This study examined the effects of the use of this therapy and of the anastomotic sealing with TachoSil, a fibrin-thrombin coated ...
Wang Yanhuang Y School and Hospital of Stomatology, Fujian Medical - - 2014
Enterococcus faecalis poses a challenge to the efficacy of traditional root canal disinfection methods. This study was aimed to establish a synergistic root canal disinfection strategy combining ultrasonic irrigation with photodynamic therapy (PDT) together and to test its antibacterial efficacy against E. faecalis. Twenty-seven bovine root canals infected with E. ...
Piaggesi Alberto A Diabetic Foot Section, Department of Medicine, Azienda Ospedaliero-Universitaria Pisana, Via Paradisa, Pisa, Italy - - 2014
We evaluated the safety and efficacy of sulodexide, a biocompound of glycosamin-glicans, as adjunct medical therapy to percutaneous transluminal angioplasty (PTA) in diabetes mellitus (DM) patients with critical limb ischemia (CLI). We studied 27 consecutive DM patients with CLI successfully subjected to PTA who, on top of standard antiplatelet therapy, ...
Marco Helena - - 2014
Rituximab is a B cell depleting anti-CD20 monoclonal antibody. CD20 is not expressed on mature plasma cells and accordingly rituximab does not have immediate effects on immunoglobulin levels. However, after rituximab some patients develop hypogammaglobulinaemia. We performed a single centre retrospective review of 177 patients with multisystem autoimmune disease receiving ...
La Torre Francesco - - 2014
Juvenile idiopathic arthritis is a relatively common chronic disease of childhood, and is associated with persistent morbidity and extra-articular complications, one of the most common being uveitis. The introduction of biologic therapies, particularly those blocking the inflammatory mediator tumor necrosis factor-alpha, provided a new treatment option for juvenile idiopathic arthritis ...
Stryjewski Martin E - - 2014
Staphylococcus aureus bacteremia is a common infection associated with significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide active against Gram-positive pathogens, including methicillin-resistant S. aureus (MRSA). We conducted a randomized, double-blind, Phase 2 trial in patients with uncomplicated S. aureus bacteremia. Patients were randomized to either telavancin or standard ...
Malani Anurag N AN Department of Internal Medicine Section of Infectious - - 2014
 Voriconazole was 1 of 2 antifungal agents recommended for treatment of fungal infections associated with injection of contaminated methylprednisolone. Alopecia and nail changes are not commonly reported side effects of voriconazole. Having noted increasing hair loss among our patients treated with voriconazole, we sought to determine the prevalence and characteristics ...
Arnoldner Michael A MA *Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Boston, MA; †Corneal and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA; ‡Department of Ophthalmology, Cogan Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA; and §Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
To report a case of successful medical treatment with oral posaconazole in refractory fungal keratitis caused by Paecilomyces lilacinus. Case report. A 57-year-old male, soft contact lens wearer presented with irritation, pain, photophobia, and reduced vision. Slit-lamp examination showed a large corneal epithelial defect with a peripheral infiltrate. The patient ...
Jaspers Aurélie A Department of Medicine, Division of Hematology, CHU of Liege and University of Liege, Liege, - - 2014
We conducted a prospective randomized trial to assess hemoglobin (Hb) response to recombinant human erythropoietin (rhEPO) therapy after hematopoietic cell transplantation (HCT). Patients (n=131) were randomized (1:1) between no treatment (control arm) or erythropoietin (Neorecormon®) at 500 U/kg/week (EPO arm). Patients were also stratified in 3 cohorts: patients undergoing myeloablative ...
Florescu Cosmin C Diagnostic Imaging, Monash Health, Melbourne, Victoria, - - 2014
The literature suggests that endovenous laser is less efficacious in great saphenous veins (GSVs) with a diameter of greater than 1 cm. This paper describes the efficacy of endovenous laser therapy (EVLT) in ablating GSV with a diameter greater than 1.0 cm. Retrospective review of consecutive patients undergoing GSV EVLT between 15 ...
Nomura Hideyuki H The Center for Liver Disease, Shin-kokura Hospital, Kitakyushu, Japan. Electronic address: - - 2014
This study aims to evaluate the efficacy and safety of interferon-beta plus ribavirin therapy in older Japanese patients. This study enrolled 132 older patients (age, ≥65 years) with chronic hepatitis C who received 24-48 weeks of interferon-beta plus ribavirin (FR; n = 66) or pegylated interferon-alpha plus ribavirin (PR; n = 66) therapy. Patients ...
Nenu Iuliana I Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 1 Clinicilor Street, 400006 Cluj-Napoca, - - 2014
The aim of our study was to assess the effect of the combined treatment of Metformin (Metf) and 5, 10, 15, 20-tetra-sulfophenyl-porphyrin (TSPP)-mediated photodynamic therapy (PDT) on an in vivo tumour model. Wistar male rats were divided in 6 groups: group 1, treated with TSPP; groups 2 and 4 treated ...
Kim Bong Jik BJ Department of Otolaryngology-Head & Neck Surgery, Dankook University College of Medicine, Cheonan, Korea. ; Department of Otorhinolaryngology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, - - 2014
The purpose of this study was to evaluate the therapeutic effect of three different types of sounds on tinnitus patients undergoing tinnitus retraining therapy (TRT). This is a single-institution retrospective study, performed in one tertiary otological referral center. Thirty-eight adults with subjective idiopathic tinnitus who were followed for at least ...
Rodger Marc M Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, - - 2014
Patients who experience venous thromboembolism (VTE) are at important risk for recurrent VTE[1]. When it occurs, recurrent VTE may have serious consequences. Recurrent VTE is fatal in more than 1 in 10 patients if experienced in the first 3 months of therapy and after the initial 3 months of therapy, ...
Takazono Takahiro T Department of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan; Department of Respiratory Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: - - 2014
The novel biological agent recombinant human thrombomodulin (rhTM) has been used clinically in Japan to treat disseminated intravascular coagulation (DIC) since 2008. Previous studies have shown the efficacy of rhTM versus heparin therapy or non-rhTM therapy. We retrospectively evaluated and compared the efficacies of rhTM and gabexate mesilate (GM) in ...
Maessen-Visch M Birgitte MB Rijnstate Ziekenhuis, Arnhem, the Netherlands - - 2014
The revised guideline of 2013 is an update of the 2005 guideline "venous leg ulcer". In this special project four separate guidelines (venous leg ulcer, varicose veins, compression therapy and deep venous disorders) were revised and developed simultaneously. A meeting was held including representatives of any organisation involved in venous ...
van der Velden Sk S Department of Dermatology, Erasmus MC, Rotterdam, the Netherlands - - 2014
Compression therapy is still the cornerstone in the treatment of PTS. The therapy is primarily focused on the decrease of the AVP, enhancement of the microcirculation and reduction of the edema. In our practice, most patients are initially treated with short stretch bandage to reduce the edema. Medical Elastic Compression ...
Bouman Ac A Laboratory for Thrombosis and Hemostasis, Maastricht University Medical Centre, Maastricht, the Netherlands Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands - - 2014
After deep vein thrombosis (DVT) 20-50%, of patients develop post thrombotic syndrome (PTS). Up till now, there is no effective treatment for PTS and prevention is therefore of major importance. Compression therapy after DVT, with elastic compression stockings (ECS), is the only available preventive measure for PTS. However, the usefulness, ...
< 1 2 3 4 5 6 7 8 9 10 >