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Results 201 - 250 of 4164
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Chen Bing-Wei BW Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, 167 Beilishilu, Beijing, 100037, People's Republic of - - 2014
Although dual-chamber (DC) cardioverter defibrillators (ICDs) offer theoretical advantage over single-chamber (SC) ICDs, clinical studies showed conflicting results. The aim of this systematic review and meta-analysis was to compare DC and SC ICDs. A systematic search of publications in PubMed, Embase, and the Cochrane Library without language restriction was performed. ...
Russo Giulia G aCentro cardiovascolare ASS-1 Triestina bVilla Bianca Hospital, Trento cS. Cuore-Don Calabria Hospital- Negrar-Verona dOspedale Civile 'S. Martino', Belluno eOspedale 'S. Camillo', Roma fAzienda ospedaliera 'S. Maria', Terni gCRO, IRCCS Aviano hIRCCS Istituto tumori 'Pascale', Napoli iIRCCS Istituto tumori 'Giovanni Paolo II', Bari jSpedali civili, Brescia, - - 2014
Adjuvant trastuzumab therapy improves the survival of human epidermal growth factor receptor 2 (HER2)-positive women with early breast cancer (EBC). Trastuzumab-induced cardiotoxicity is not uncommon. In the setting of community patients, the incidence, timing and phenotype of new onset congestive heart failure (CHF) is unknown. Four hundred and ninety-nine consecutive ...
Mustafa Mahiran M Department of Medicine, Hospital Raja Perempuan Zainab II, 15000 Kota Bharu, Kelantan, Malaysia. Electronic address: - - 2014
Doripenem is approved in the Asia-Pacific (APAC) region for treating nosocomial pneumonia (NP) including ventilator-associated pneumonia (VAP), complicated intra-abdominal infections (cIAIs) and complicated urinary tract infections (cUTIs). Clinical usage of doripenem (500mg intravenously, infused over 1h or 4h every 8h for 5-14 days) in APAC was evaluated in a prospective, ...
Kiany Farin F Oral and Dental Health Care Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, - - 2014
The present study investigated the effect of non-surgical periodontal therapy on serum level of anti-cardiolipin antibodies (aCLA), which are potentially involved in the pathogenesis of cardiovascular diseases in periodontal patients. Twenty volunteers (11 females and 9 males) with the mean age of 40.55 years participated in this study. Generalized chronic periodontitis ...
Arai Keiko K 1 Arai Clinic , Yokohama, Japan - - 2014
Abstract Background: In a previous single-center, open-label randomized 3-month study of triple oral antidiabetes drug (OAD) therapy, we investigated factors affecting the glycemic control afforded by sitagliptin, high-dose metformin, and low-dose glimepiride. Patients were prospectively assigned to either Group 1 (50% reduction in metformin) or Group 2 (discontinuation of glimepiride) ...
Pourabbas Reza R Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
Background: There are limited clinical experiments addressing the effects of photodynamic therapy (PDT) as an adjunct to conventional scaling/root planing (SRP) on clinical and biological features of periodontitis. This trial compares the clinical parameters and cytokine profiles in gingival crevicular fluids of patients with moderate to severe chronic periodontitis who ...
Motzer Robert J RJ Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: - - 2014
An unmet medical need exists for patients with metastatic renal cell carcinoma who have progressed on VEGF-targeted and mTOR-inhibitor therapies. Fibroblast growth factor (FGF) pathway activation has been proposed as a mechanism of escape from VEGF-targeted therapies. Dovitinib is an oral tyrosine-kinase inhibitor that inhibits VEGF and FGF receptors. We ...
Bauman Nancy M NM Department of Otolaryngology, Children's National Medical Center, Washington, - - 2014
IMPORTANCE While propranolol is touted as superior to prednisolone for treating infantile hemangiomas (IH), a randomized clinical trial (RCT) comparing the outcome and tolerability of these medications for symptomatic, proliferating IH has not been reported. OBJECTIVES To determine if oral propranolol is more efficacious and better tolerated than prednisolone in ...
Lam Byron L BL Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, - - 2014
IMPORTANCE Establishing the natural history of G11778A Leber hereditary optic neuropathy (LHON) is important to determine the optimal end points to assess the safety and efficacy of a planned gene therapy trial. OBJECTIVE To use the results of the present natural history study of patients with G11778A LHON to plan ...
Farkas Klaudia K First Department of Medicine, University of Szeged, Szeged, Hungary. Electronic address: - - 2014
The effects of short course of corticosteroids on the metabolic processes and bone formation has not been well studied. Our aim was to compare the efficacy, the side effects and the bone and lipid metabolisms in IBD patients using bolus or conventional tapering of methylprednisolone for 12weeks. Nineteen IBD patients ...
Kosiuk Jedrzej J Department of Electrophysiology, Heart Center, Leipzig 04289, - - 2014
Atrial fibrillation (AF) is associated with frequent appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapies. Catheter ablation of AF has been shown to reduce AF burden and improve left ventricular function in heart failure patients but the impact on ICD therapies has not yet been studied. The aim of this ...
Cerón I I Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, - - 2014
Enterococcus spp. account for 10% of infective endocarditis (IE). Although daptomycin is a bactericidal drug with in vitro activity against Enterococcus, there is little experience of its use in IE. We analysed the effectiveness of daptomycin in the treatment of enterococcal IE (EIE). This was a retrospective descriptive study comparing ...
Crandley Edwin F EF Department of Radiation Oncology, University of Virginia, Charlottesville, - - 2014
Intensity-modulated radiation therapy (IMRT) is frequently utilized after prostatectomy without strong evidence for an improvement in outcomes compared to conformal radiation therapy (RT). We analyzed a large group of patients treated with RT after radical prostatectomy (RP) to compare complications after IMRT and CRT. The Surveillance, Epidemiology and End Results ...
Pajardi Giorgio G Unità Operativa Complessa di Chirurgia della Mano, Università degli Studi di Milano, Ospedale San Giuseppe Milan /IRCCS MultiMedica, Milano, - - 2014
Chronic wounds are an expression of underlying complex pathologies and have a high incidence. Skin substitutes may represent an alternative approach to treat chronic ulcers. The aim of this retrospective observational study was to evaluate the wound reduction using skin substitutes based on allogenic fibroblasts or keratinocytes in 30 patients ...
Chiono Julien J From the Department of Anesthesiology and Critical Care Medicine, University Montpellier I, and Lapeyronie University Hospital, Montpellier, - - 2014
The authors investigated the efficacy of bilateral suprazygomatic maxillary nerve block (SMB) for postoperative pain relief in infants undergoing cleft palate repair. In this prospective, double-blind, single-site, randomized, and parallel-arm controlled trial, 60 children were assigned to undergo bilateral SMB with general anesthesia with either 0.15 ml/kg of 0.2% ropivacaine (Ropi ...
Scott Paul A PA Department of Cardiology, King's College Hospital NHS Foundation Trust, London, UK. Electronic address: - - 2014
Programming long arrhythmia detection times can reduce the incidence of ICD shock therapy. However potential concerns exist regarding the impact on mortality and incidence of syncope. We performed a meta-analysis to better gauge the impact of prolonged arrhythmia detection times on the rates of ICD shock therapy and other adverse ...
Apollonio Alessandro A Operative Unit of Angiology, Belcolle Hospital, Viterbo, - - 2014
An observational study of 2 years was promoted by the Italian Association for Cutaneous Ulcers (AIUC) in order to monitor the epidemiology of leg ulcers, the trend of healing and the more frequent therapeutic approaches in lower limb ulcers. Fifty-nine sites in 14 different Italian regions involved in the study, with ...
de Paula Eduardo Fernanda F Unit of Bone Marrow Transplantation, Hospital Israelita Albert Einstein, São Paulo, - - 2014
Melphalan followed by hematopoietic stem-cell transplantation (HSCT) is the standard treatment for multiple myeloma and other hematopoietic neoplasms. However, high doses of melphalan cause severe oral mucositis (OM). The objective was to verify the efficacy of cryotherapy plus laser therapy on reduction of OM severity. HSCT patients undergoing melphalan chemotherapy ...
Pitt Kathryn A KA Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, - - 2014
To report experience with negative pressure wound therapy (NPWT) in 45 consecutive dogs admitted with extensive cutaneous wounds and to determine if NPWT is feasible in veterinary hospital practice. Prospective descriptive study. Dogs (n = 45). Collected data were organized into 6 categories: patient data, wound data, NPWT data, adjunctive treatments, complications, ...
Bishop Bryan M BM Summa Health System, Akron City Hospital, Akron, OH, - - 2014
Utilizing procalcitonin (PCT) levels to limit antimicrobial overuse would be beneficial from a humanistic and economic perspective. To assess whether introducing PCT at a teaching hospital reduced antimicrobial exposure in critically ill patients. Patients wereadmitted to the intensive care unit (ICU) for >72 hours with sepsis and/or pneumonia. PCT levels ...
Akasheh Goudarz G Kashan University of Medical Sciences, Kashan, - - 2014
To investigate the effects of sertraline on semen parameters and comparison of its effect with behavioral therapy (BT) in men with primary premature ejaculation. In this single-blinded clinical trial, a total of 60 married men with primary premature ejaculation were randomly divided into 2 groups: the sertraline group (n = 30, ...
Almeida Nuno N Gastroenterology Department, Coimbra University Hospital, Coimbra, - - 2014
Helicobacter pylori resistance to antibiotics is steadily increasing and multidrug-resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable. To evaluate the efficacy and safety of a triple therapy with proton-pump inhibitor (PPI), amoxicillin, and doxycycline in patients with multidrug-resistant H. pylori. ...
Krebbel Holger H Department of Anaesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Charité Mitte and Campus Charité Virchow-Klinikum, Berlin, - - 2014
To investigate changes in standard base excess (SBE) when administering two different infusion regimens for elective hip replacement within a goal-directed haemodynamic algorithm. This prospective, double-blind, randomized, controlled study enrolled patients scheduled for primary hip replacement surgery, who were randomized to receive either an unbalanced crystalloid (chloride: 155.5 mmol/l) or a ...
Harivenkatesh Natarajan N 1Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, - - 2014
Introduction:The long half-life of atorvastatin and fenofibrate makes them suitable for alternate day therapy. Hence, we aimed to study the efficacy, safety, and cost-effectiveness of alternate day therapy with atorvastatin and fenofibrate combination in mixed dyslipidemia. Eligible patients with mixed dyslipidemia were randomly allotted into 2 equal parallel groups-alternate day ...
Akdag Arzu A Department of Neonatology, Zekai Tahir Burak Maternity and Teaching Hospital Ankara, - - 2014
Objective To investigate the effectivity of pentoxifylline (PTX) and immunoglobulin M (IgM)-enriched intravenous immunoglobulin (IVIG) therapy in the treatment of neonatal sepsis (NS), alone or in combination. Study design This was a prospective, double-blind, controlled study. Newborns with suspicion of sepsis were enrolled in the study. The patients were separated into four ...
Zhou Peiyang P Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, People's Republic of China; Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang 441000, Hubei Province, People's Republic of - - 2014
The purpose of this study is to validate the efficacy of intensive statin therapy for patients with atherosclerotic intracranial arterial stenosis (AICAS). In this study, we performed a single-center, randomized, single-blind, parallel-group clinical trial. A total of 120 Chinese patients with AICAS were enrolled and randomly divided into three groups ...
Demirkol Nermin N Department of Prosthodontics, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey, - - 2014
The present study was designed to evaluate the effects of low-level laser (Nd:YAG) therapy and occlusal splints in patients with signs and symptoms of temporomandibular disorders (TMD) characterized with myofascial pain (MP). A total of 30 patients were selected after being diagnosed with MP according to the Research Diagnostic Criteria ...
Keam Jennifer J Departments of Radiation - - 2014
Object Radiation therapy is known to impair wound healing. Higher dose per fraction is believed to increase this risk. This study sought to quantify rates of wound complication in patients receiving preoperative conventionally fractionated radiotherapy (XRT) or high-dose hypofractionated image-guided radiation therapy (IGRT) for spinal metastasis, and to identify predictors ...
Silber Sigmund S Heart Center at the Isar, Am Isarkanal 36, D-81379 Munich, - - 2014
The optimal duration of dual antiplatelet therapy (DAPT) following the use of new generation drug-eluting stents is unknown. The association between DAPT interruption and the rates of stent thrombosis (ST) and cardiac death/target-vessel myocardial infarction (CD/TVMI) in patients receiving a Resolute zotarolimus-eluting stent (R-ZES) was analysed in 4896 patients from ...
Moroni Gabriella G Divisione di Nefrologia & Dialisi, IRCCS Fondazione Ca' Granda, Ospedale Maggiore, Mangiagalli, Regina Elena, Divisone di Nefrologia e Immunologia clinica, Ospedale San Carlo Borromeo, Dipartimento di Reumatologia, Unita' Operativa di Day Hospital, Istituto G. Pini and Dipartimento di Reumatologia, Istituto G. Pini and IRCCS Istituto Auxologico Italiano, Milano, - - 2014
Objective. We report the first comparison between rituximab (RTX) and either MMF or CYC pulses in the treatment of active LN.Methods. Fifty-four patients with active LN received three methylprednisolone pulses for 3 consecutive days followed by oral prednisone and RTX 1 g at days 3 and 18 (17 patients) or ...
Crews Deidra C DC Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD. Electronic address: - - 2014
Previous observational studies examining outcomes associated with the timing of dialysis therapy initiation in the United States have often been limited by lead time and survivor bias. Retrospective cohort study comparing the effectiveness of early versus later (conventional) dialysis therapy initiation in advanced chronic kidney disease (CKD). The analysis used ...
Yaroustovsky M M Bakoulev Scientific Centre for Cardiovascular Surgery, Moscow, - - 2014
Introduction: Sepsis still represents an obstacle in modern medicine. The aim of this study was to evaluate the effectiveness and safety of the combined use of lipopolysaccharide adsorption and haemodialysis (HD) with high cut-off haemofilters as part of the complex intensive care of patients with severe sepsis after cardiac surgery. ...
Brown Jessica J *CHOC Children's Hospital †Department of Psychology CHOC Children's Hospital of Orange County ‡Department of Rehabilitation CHOC Children's Hospital §Department of Clinical Nutrition and Lactation CHOC Children's Hospital of Orange County ||Department of Rehabilitation CHOC Children's Hospital of Orange County ¶Department of Social Services CHOC Children's Hospital of Orange County #Division of Pediatric Gastroenterology and Nutrition CHOC Children's Hospital of Orange - - 2014
The current study evaluated the effectiveness of a multidisciplinary intensive inpatient model for gastrostomy tube (GT) weaning. A retrospective chart review was completed on 30 GT dependent children, ages 3.9 (±1.4) years, admitted to the inpatient feeding program (length of stay 19 days) from May 2009 to December 2011. Administered ...
Arweiler Nicole Birgit NB Department of Periodontology, Philipps-University, 35039, Marburg, Germany, - - 2014
The use of antibacterial photodynamic therapy (aPDT) additionally to scaling and root planing (SRP) has been shown to positively influence the clinical outcomes. However, at present, it is unknown to what extent aPDT may represent a potential alternative to the use of systemic antibiotics in nonsurgical periodontal therapy in patients ...
Kobayashi Yoshihisa Y Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, - - 2014
Spinal epidural hematoma (SEH) is rare but causes neurological disorders. Rapid diagnosis and treatment maximize neurological recovery. We present the case of SEH after lung cancer surgery under epidural and general anesthesia. A 64-year-old man underwent right upper lobectomy. Pulmonary embolism occurred on postoperative day 2. Anticoagulant therapy with fondaparinux ...
Selinger Christian P CP Gastroenterology and Liver Services, Concord Hospital and Bankstown Hospital, Sydney, - - 2014
Aminosalicylate (5-ASA) is effective treatment for inflammatory bowel diseases (IBDs) but requires continuous maintenance therapy. This study determines persistence of 5-ASA in IBD using national population-based data for Australia from 2002 to 2011 with follow up for 36 months. Non-persistence was defined as failing to fill a prescription for 3 ...
Nakayama Masaaki M Research of Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, - - 2014
Introduction: Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD). Over the past decade in Japan, a multidisciplinary approach has been adopted to minimize the incidence and improve outcomes of EPS. This strategy includes planned PD discontinuation for high-risk patients and the introduction of biocompatible solutions. This ...
Kearon C C Professor, Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, - - 2014
It takes about 3 months to complete "active treatment" of venous thromboembolism (VTE), with further treatment serving to prevent new episodes of thrombosis ("pure secondary prevention"). Consequently, VTE should generally be treated for either 3 months or indefinitely (see text for exceptions). The decision to stop anticoagulants at 3 months ...
de Joode Anoek A E AA Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The - - 2014
Objective: We evaluated 26 patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) with progressive disease despite treatment with cyclophosphamide and steroids treated with additional plasmapheresis and compared outcome with 50 matched-disease controls. Methods: Patients diagnosed with AAV and treated with cyclophosphamide from January 1990 to December 2009 (n = 272) were included ...
Steinberg Jonathan S JS The Arrhythmia Institute, Valley Health System, New York, NY and Ridgewood, NJ. Electronic address: - - 2014
Ablation of atrial fibrillation (AF) using pulmonary vein isolation is employed when patients do not respond favorably to medical therapy. Successful procedures are accomplished in the majority of patients, but the outcome after many years of follow-up after ablation is unknown. To describe the long-term recurrence rate and pattern of ...
Park Hyoung-Chul HC Department of Surgery, Hallym University College of Medicine, Anyang, - - 2014
Although many patients received antibiotic therapy for appendicitis, it is unclear if this treatment can be administered to elderly patients. We aimed to assess the outcomes of antibiotic therapy for appendicitis in elderly patients aged ≥ 80 years. During this 4-year study, we enrolled 26 elderly patients who initially received ...
Fukami Y Y Department of Surgery, Toyota Kosei Hospital, 500-1 Josui-cho, Toyota, Aichi, 470-0396, - - 2014
Hyperbaric oxygen (HBO) therapy is a controversial treatment for adhesive postoperative small bowel obstruction, with only a few small studies reported. The aim of this study was to assess the clinical value of HBO therapy in the treatment of adhesive postoperative small bowel obstruction. Between April 2006 and March 2012, ...
Schulz-Juergensen Sebastian S Department of General Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, Haus 9, 24105, Kiel, Germany, - - 2014
Alarm therapy is a long-established first-line therapy for nocturnal enuresis (NE). Desamino-arginine vasopressin (dDAVP) as alternative first-line therapy was shown to increase the prepulse inhibition (PPI) of startle reflexes, thus supporting the hypothesis of a maturational delay of reflex inhibition in NE. Effects of alarm therapy on PPI have not ...
Koshy Aaron A Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, - - 2014
Primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is a therapeutic success when supported by dual antiplatelet therapy. Prasugrel has been introduced as a potential alternative to clopidogrel alongside aspirin. We aimed to assess prasugrel versus clopidogrel mortality outcomes in patients admitted with STEMI undergoing PPCI. Retrospective ...
Gao Feng F Department of Aesthetic, Plastic and Burn Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shangdong 250021, - - 2014
Maxillary anterior segmental distraction osteogenesis (MASDO) is a recently used method for correction of severe maxillary retrusion in cleft lip and palate (CLP) patients. In this article, we evaluated the feasibility of MASDO using rigid external distraction (RED) and rapid orthodontic tooth movement to correct severe maxillary retrusion in CLP ...
Xu Qianghong Q Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang 310007, - - 2014
Few studies have reported the effect of different volume responsiveness evaluation methods on volume therapy results and prognosis. This study was carried out to investigate the effect of two volume responsiveness evaluation methods, stroke volume variation (SVV) and stroke volume changes before and after passive leg raising (PLR-ΔSV), on fluid ...
Wang Jian-Min JM Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, ChongQing, - - 2014
Atherosclerosis and accompanying cardiovascular disease are the first causes of mortality in patients undergoing maintenance hemodialysis. Anti-atherosclerotic effects of hemodiafiltration (HDF) have been reported. Our study aimed to investigate the effect of serum derived from a healthy group (n = 23), before and after hemodialysis (HD) therapy (n = 23), and before and after ...
Aihara Hideaki H 1 Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, - - 2014
Purpose : To report long-term outcomes of endovascular therapy (EVT) for aortoiliac bifurcation lesions. Methods : Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who underwent EVT for de novo aortoiliac disease between January 2005 and December 2009, 190 ...
Baldo A A Section of Clinical, Allergological and Venerological Dermatology Department of Clinical Medicin and Surgery University of Naples Federico II, Naples, Italy - - - 2014
Aim: The aim of the present study was to evaluate the efficacy and safety of narrowband UVB (NB-UVB) compared with tacrolimus ointment 0.1% in patients with bilateral vitiligo. Methods: In this comparative study, four groups of patients were randomized. Each group was composed by 12 patients with bilateral vitiligo; in ...
Jandourek Alena A Director, Clinical Development; Cerexa, Inc., Oakland, CA. - - 2014
Objectives: Few publications of prospective studies have described patient outcomes in community-acquired bacterial pneumonia (CABP)-associated bacteremia. Our objective, in performing this subgroup analysis, was to assess outcomes in subjects with CABP-associated bacteremia in 2 randomized, double-blind clinical studies comparing treatment with ceftaroline fosamil versus ceftriaxone. Methods: Our analysis summarizes baseline ...
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