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Gola M M Allergological and Occupational Dermatology Department of Surgery and Translational MedicineUniversity of Florence, Florence, Italy - - - 2014
We examined and evaluated the clinical characteristics of patients who had come to the Allergological and Occupational Dermatology unit in Florence with severe CHE refractory to potent topical corticosteroids. We evaluated the efficacy and safety of alitretinoin and we analyzed the response in the three months of follow-up in the ...
Fabbrocini G G Section of Clinical Dermatology Allergology and Venereology, Department of Clinical Medicine and Surgery University of Naples Federico II, Naples, Italy - - - 2014
The purpose of the study was to analyze the potential capacity of a dietary supplement, based on gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10 and Vitis Vitifera, to reduce side effects, in particular the dry skin, erythema and desquamation, due to treatment with oral isotretinoin, and evaluate ...
Cerim Alma A Eye Department, 2Department of Internal Medicine; Cantonal Hospital Zenica, Zenica, Bosnia and - - 2014
Aim To determine the occurrence and morphological characteristics of cataracts and the impact of general steroid therapy on its occurrence. Methods A retrospective/prospective study was conducted on 90 patients who had been treated at the Cantonal Hospital Zenica with general steroid therapy. There were 30 patients whose general steroid therapy ...
Sadibašić Belma B 1Department of Psychiatry, Cantonal Hospital Zenica, 2Department of Internal Medicine, General Hospital Sarajevo, Sarajevo; Bosnia and - - 2014
Aim To investigate the incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with antipsychotics of new generation compared to conventional therapy. Methods This retrospective study included 116 chronic psychiatric patients divided into two groups: a test group who were on treatment with antipsychotics of the new generation and a ...
Neisius Andreas A Department of Urology, Universitätsmedizin Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany, - - 2014
Following its introduction in 1980, shock wave lithotripsy (SWL) rapidly emerged as the first-line treatment for the majority of patients with urolithiasis. Millions of SWL therapies have since been performed worldwide, and nowadays, SWL still remains to be the least invasive therapy modality for urinary stones. During the last three ...
Liu Yu-Hua YH Department of Infectious Diseases, the First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China, - - 2014
Currently available monotherapies of oral nucleoside/nucleotide analogs or interferon are unable to achieve a sustained and effective response in most of patients with chronic hepatitis B (CHB). The objective of the present study was to compare the efficacy and safety of pegylated interferon (Peg-IFN) alpha-2b plus adefovir dipivoxil combination therapy ...
Millen A A Clinical Research Fellow, Royal Liverpool University Hospital; - - 2014
Lower limb ulcers that are resistant to standard forms of treatment place a significant burden on both patients and health services. There is no widely agreed definition of a recalcitrant ulcer but failure to heal following 6-12 months of focused treatment would identify a small group of patients with highly ...
Olímpio Hugo de Oliveira Hde O Campinas State University (UNICAMP), Surgery, Campinas/SP, - - 2014
Here, we describe our experience with different therapeutic modalities used to treat cystic lymphangiomas in children in our hospital, including single therapy with OK-432, bleomycin and surgery, and a combination of the three modalities. We performed a retrospective, cross-sectional study including patients treated from 1998 to 2011. The effects on ...
Kedia Margaret M Campbell Clinic, Southaven, MS, - - 2014
Single-blind, randomized, clinical trial. The effect of eccentric training for mid-portion Achilles tendinopathy is well documented; however, its effect on insertional Achilles tendinopathy is inconclusive. The primary purpose of this study was to investigate the effect of eccentric training on pain and function for individuals with insertional Achilles tendinopathy. All ...
Wang Zheng-Xu ZX Biotherapy Center, the General Hospital of Beijing Military - - 2014
Aim: Peripheral arterial disease (PAD), particularly critical limb ischemia (CLI), is a severe cause of amputation and mortality. More than 50% of diabetic patients with CLI die within four to five years. The development of novel stem cell therapies may bring new hope to these patients. We aimed to assess ...
Brinjikji W W From the Departments of Radiology (W.B., H.J.C., D.F.K.) and Neurosurgery (S.F.M.-V., H.J.C., D.F.K.) and Center for Science of Healthcare Delivery (M.H.M.), Mayo Clinic, Rochester, Minnesota. - - 2014
Intraprocedural thrombus formation during endovascular treatment of intracranial aneurysms is often treated with glycoprotein IIb/IIIa inhibitors and, in some instances, fibrinolytic therapy. We performed a meta-analysis evaluating the safety and efficacy of GP IIb/IIIa inhibitors compared with fibrinolysis. We also evaluated the safety and efficacy of abciximab, an irreversible inhibitor, ...
Ritter Markus M Department of Ophthalmology, Medical University of Vienna, Vienna, - - 2014
To investigate the impact of antiangiogenic monotherapy and photodynamic therapy (PDT) as add-on strategy on retinal morphology, and to analyse prognostic biomarkers for visual outcome and retreatment frequency in neovascular age-related macular degeneration (nAMD). 255 patients participating in the MONT BLANC study were evaluated. Patients were randomised to receive as-needed ...
Gibson D J DJ Centre for Colorectal Disease, St Vincent's University Hospital, and School of Medicine and Medical Science, University College Dublin, Ireland. Electronic address: - - 2014
& Aims: Administration of infliximab to patients with acute severe ulcerative colitis (ASUC, rescue therapy) can reduce the rate of early colectomy (within 12 months), but long-term rates of colectomy are the same as those of the pre-biologic era for these patients. The half-life of infliximab is shorter in patients ...
Ghatnekar Gautam G FirstString Research, Inc., Mount Pleasant, SC, - - 2014
The gap junction protein, connexin43 (Cx43) has critical roles in the inflammatory, edematous and fibrotic processes following dermal injury and during wound healing and is abnormally upregulated at the epidermal wound margins of venous leg ulcers. Targeting Cx43 with ACT1, a peptide mimetic of the carboxyl-terminus of Cx43, accelerates fibroblast ...
Yadav Hemang H From the *Departments of Pulmonary and Critical Care Medicine, †Health Sciences Research, ‡Anesthesiology, §Division of Vascular Surgery, Department of Surgery, and ‖Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, - - 2014
Statins have been shown to possess antiinflammatory and immunomodulatory effects. In this study, we sought to determine if preoperative statin therapy is associated with a reduced frequency of postoperative acute respiratory distress syndrome (ARDS) in surgical populations at increased risk of developing ARDS. We performed a retrospective cohort evaluation of ...
Timmer Margriet R MR Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The - - 2014
Endoscopic therapy for the treatment of high-grade dysplasia (HGD) and intramucosal cancer (IMC) in Barrett's esophagus (BE) may not always result in complete remission of dysplasia (CRD). To determine whether genetic alterations in the Barrett's mucosa can predict response to endoscopic therapy. Retrospective cohort study. Tertiary-care institution. Selected patients who ...
Vajpayee Rasik B RB Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi-110029, India; Centre for Eye Research Australia, University of Melbourne, - - 2014
To report the treatment outcomes of mycotic keratitis with collagen crosslinking (CXL). Retrospective study PARTICIPANTS: Patients with smear-positive moderate mycotic keratitis METHODS: A retrospective case-file analysis was performed to identify cases of moderate mycotic keratitis treated with and without additional CXL in addition to intensive topical antifungal therapy. Patients in ...
Sebastiani Marco M Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address: - - 2014
Rituximab (RTX) is a monoclonal anti-CD20 antibody approved for the treatment of rheumatoid arthritis (RA) in association with methotrexate (MTX). To evaluate the efficacy and safety of RTX-MTX combination therapy compared with RTX alone in the treatment of RA. We analyzed data from a prospective cohort study, the Italian biologic ...
El-Beshlawy Amal A Cairo University, Cairo, Egypt, - - 2014
Hydroxycarbamide (hydroxyurea or HU) has been shown to increase fetal hemoglobin (HbF) in patients with β-thalassemia intermedia (TI). The reported effects of HU in increasing the total hemoglobin (Hb) have been inconsistent. Studies of long-term therapy with HU in pediatric TI are rather uncommon. A retrospective observational study was carried ...
Mercimek-Mahmutoglu Saadet S Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada; Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: - - 2014
Pyridoxine dependent epilepsy (PDE) due to mutations in the ALDH7A1 gene (PDE-ALDH7A1) is caused by α-aminoadipic-semialdehyde-dehydrogenase enzyme deficiency in the lysine pathway resulting in the accumulation of α-aminoadipic acid semialdehyde (α-AASA). Classical presentation is neonatal intractable seizures with a dramatic response to pyridoxine. Pyridoxine therapy does not prevent developmental delays ...
Maleux Geert G Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium, - - 2014
To retrospectively analyse the technical and clinical outcomes of embolotherapy for post-biliary sphincterotomy bleeding refractory to medical and endoscopic therapy, and in addition, to analyse factors potentially influencing 30-day mortality. From November 1998 to November 2012, 34 patients underwent percutaneous embolotherapy for post-biliary sphincterotomy bleeding refractory to medical and endoscopic ...
Esmat Gamal G 1 Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University , Cairo, Egypt - - 2014
The current standard of care therapy (SOC) for chronic HCV is pegylated interferon/ribavirin (Peg-IFN/RBV). Many reports showed the possible role of vitamin D supplementation in augmenting the response to SOC. The aim of this study was to assess the role of vitamin D supplementation on the response to treatment in ...
Gölz Leonie L Department of Neurosurgery, Unfallkrankenhaus Berlin, - - 2014
Object Shunt therapy in idiopathic normal pressure hydrocephalus (iNPH) can improve symptoms in 84% of patients 1 year postoperatively. Therefore, implantation of a ventriculoperitoneal shunt (VPS) prevents or at least prolongs the time during which patients are not dependent on care from others because of gait disorder or dementia. In ...
Hardesty Douglas A DA Divisions of Neurological Surgery - - 2014
Object Coccidioidomycosis is a common fungal infection in the southwestern US. Hydrocephalus is a serious complication of cranial coccidioidomycosis, and the surgical management of coccidioidomycosis-related hydrocephalus has unique challenges. The authors reviewed their institutional experience with hydrocephalus in the setting of coccidioidomycosis. Methods The authors retrospectively identified 44 patients diagnosed ...
Seward Christopher J CJ Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Neurosurgery, Gates Vascular Institute-Kaleida Health, Buffalo, New York, - - 2014
Experience with endovascular therapy of extracranial carotid artery pseudoaneurysm (ECAP) has been growing, and various results suggest it as a suitable treatment option. We present a consecutive case series of patients with ECAPs treated with endovascular therapy, and a pertinent literature review. A prospectively maintained database of neuroendovascular procedures was ...
Lee Seong Tae ST Division of Gastroenterology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, - - 2014
Bismuth-containing quadruple and moxifloxacin-based triple regimens are recommended as second-line therapy for Helicobacter pylori infection. The aim of this study was to compare the efficacy of each regimen. From August 2004 to October 2012, a total of 949 patients (mean age, 54.32±12.08 years; male, 49.4%) who failed H. pylori eradication ...
Natali A A Department of Urology, Uro-Andrological Unit, University of Florence, Florence, - - 2014
We retrospectively analyzed the effects on the erectile function (EF) of no treatment (NT), and an oral therapy (OT; on-demand therapy (OD) or a regimented rehabilitation (RR) program with phosphodiesterase type 5 inhibitors (PDE5-Is)), in a cohort of 196 consecutive patients following nerve-sparing radical retropubic prostatectomy (NSRRP). Patients undergoing bilateral ...
Doycheva Deshka D Centre for Ophthalmology, University of Tuebingen, Tuebingen, - - 2014
To assess the long-term efficacy and tolerability of both derivatives of mycophenolic acid, mycophenolate mofetil (MMF) and mycophenolate sodium (MPS), in the therapy of patients with birdshot chorioretinopathy (BSCR). Retrospective analysis of 24 patients (48 eyes) with BSCR, treated with MMF or MPS with a follow-up of at least 1 year. ...
Sibbald Cathryn C Department of Dermatology, University of Toronto, Toronto, Ontario, - - 2014
Cyclosporine is a systemic therapy used for control of severe atopic dermatitis (AD) in children. Although traditionally recommended at a dose of 5 mg/kg/day for 6 months, a longer duration of treatment may be necessary to bring a child with active and severe disease into remission. There are few data on the ...
Mungo B B Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Neoadjuvant therapy has proven to be effective in the reduction of locoregional recurrence and mortality for esophageal cancer. However, induction treatment has been reported to be associated with increased risk of postoperative complications. We therefore compared outcomes after esophagectomy for esophageal cancer for patients who underwent neoadjuvant therapy and patients ...
Yoshikawa Norishige N Department of Pediatrics, Wakayama Medical University, Wakayama City, - - 2014
In this multicenter, open-label, randomized controlled trial, we determined whether 2-month prednisolone therapy for steroid-sensitive nephrotic syndrome was inferior or not to 6-month therapy despite significantly less steroid exposure. The primary end point was time from start of initial treatment to start of frequently relapsing nephrotic syndrome. The pre-specified non-inferiority ...
Dressler Dirk D Movement Disorders Section, Department of Neurology, Hannover Medical School, Hannover, Germany, - - 2014
We sought to explore the therapeutic effect of botulinum toxin (BT) therapy by analysing the time between the BT application and the onset of its decrease (treatment duration, TD), the inter-injection interval (II), and the excess time (ET, ET = II-TD). For this we studied 59 patients (37 females, 22 males, age ...
von Scheidt W W I.Medizinische Klinik, Herzzentrum Augsburg-Schwaben, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany, - - 2014
Limited data exist regarding baseline characteristics and management of heart failure with reduced ejection fraction (EF) in tertiary care facilities. EVITA-HF comprises web-based case report data on demography, comorbidities, diagnostic and therapy measures, quality of life, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ...
Li L L Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, USA - - - 2014
Dysphagia is not uncommon after stroke. Dysphagia may delay the functional recovery and substantially affects the quality of life after stroke, mainly if lest untreated. To detect and treat dysphagia as early as possible is critical for patients' recovery after stroke. Electrical stimulation has been reported as a treatment for ...
Samuelkamaleshkumar Selvaraj S Christian Medical College Vellore, Tamil Nadu, INDIA. Electronic address: - - 2014
To investigate the effectiveness of MT combined with bilateral arm training and graded activities to improve motor performance in the paretic upper limb following stroke. Randomized, controlled, assessor - blinded study. Inpatient stroke rehabilitation center of a tertiary care teaching hospital. Twenty patients with first time ischemic or hemorrhagic stroke, ...
Micek Scott T ST Division of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, - - 2014
Inappropriate initial therapy for Candida-related septic shock is common and associated with a high mortality rate. This before-after pilot study was conducted to determine the feasibility of using empiric therapy for reducing the time to appropriate antifungal therapy in patients with Candida-related septic shock. Patients aged 18-99years with septic shock ...
Nussbaum Daniel P DP Duke University, Department of Surgery, USA. Electronic address: - - 2014
Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on perioperative outcomes, most of which come from small, single-institution series. The purpose of this study was to evaluate ...
Oscroft Nicholas S NS Respiratory Support & Sleep Centre, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridgeshire CB23 3RE, United Kingdom. Electronic address: - - 2014
The addition of domiciliary non-invasive ventilation (NIV) to standard therapy in chronic obstructive pulmonary disease (COPD) patients with compensated ventilatory failure (CVF) is reported to have beneficial effects. Compliance with NIV is an important factor. Volume assured NIV (va-NIV) may improve compliance and ventilation during sleep by automatically titrating ventilatory ...
Yoshioka Daisuke D Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Japan, - - 2014
The aim of this study was to evaluate our clinical experience with the Jarvik 2000 axial flow pump (Jarvik Heart, Inc, New York, NY, USA), a miniature axial flow left ventricular assist device (LVAD). The clinical results of eight patients, who underwent LVAD implantation with the Jarvik 2000 (median age ...
Haegeli Laurent M LM Clinic for Cardiology, University Heart Center, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, - - 2014
Catheter ablation of atrial fibrillation (AF) is now an important therapeutic modality for patients with AF. There is considerable evidence available from several prospective randomized trials demonstrating that catheter ablation of AF is superior to antiarrhythmic drug therapy in controlling AF and that AF ablation improves quality of life substantially. ...
Jódar-Sánchez Francisco F Technological Innovation Group, Virgen del Rocío University Hospital, Seville, Spain Andalusian Public Foundation for Health Research Management in Seville, Seville, - - 2014
We conducted a cost-utility analysis of a telehealth programme for patients with severe chronic obstructive pulmonary disease (COPD) compared with usual care. A randomized controlled trial was carried out over four months with 45 patients treated with long-term oxygen therapy, 24 in the telehealth group (TG) and 21 in the ...
Gomes Beatriz Fiuza BF Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, - - 2014
To investigate the mean intraocular pressure (IOP) of patients with connective tissue disease (CTD) on low-dose chronic systemic corticosteroid therapy and compare with control subjects. Cross-sectional comparative study. A total of 86 patients with CTD were grouped according to corticosteroid therapy. Group 1 (n = 27) was composed of patients ...
Matin Marzieh - - 2014
Abstract Objectives: Usage of 308-nm excimer laser (EL) is an effective treatment in vitiligo. As genetic predispositions along with type of skin and sun exposure rate are known factor influencing the treatment outcomes we tried to evaluate treatment results of using 308nm-excimer laser alone in comparison with combined therapy of ...
Huang Congwu C Department of Gastroenterology, the Second Affiliated Hospital of Shantou University , Shantou , - - 2014
Abstract Context: Proton pump inhibitor (PPI) increases the risk of decrease in bone mineral density (BMD). However, whether calcitrol improves this situation is unknown. Objective: The current study investigates the effects of calcitriol on BMD in patients with esomeprazole therapy. Materials and methods: Three hundred and eighty-six participants with gastrointestinal ...
Zhou YuQian Y Department of Gastroenterology, The 2nd Affiliated Hospital of XiangYa Medical School, Central South University , Changsha, Hunan, China - - 2014
Abstract Introduction: This study aimed to assess the safety and effectiveness of covered self-expanding metal stents for the treatment of nonvariceal esophageal bleeding in patients for whom routine therapies have failed. Patients and Methods: A retrospective analysis was conducted on patients with esophageal bleeding in our hospital. Data on hemostatic ...
Erdei Annamaria A Division of Endocrinology, Insitute of Medicine, University of Debrecen , Debrecen , Hungary - - 2014
Abstract The aim of this investigations was to study the effectiveness of anti-CD20 antibody therapy in Graves' orbitopathy (GO) resistant to glucocorticoids. Five patients were entered in the study. The protocol required no improvement of orbital status after a recent course of glucocorticoids. Activity of GO was confirmed by three ...
Papadopoulos N N Division of Thoracic and Cardiovascular Surgery, University Frankfurt/Main, Germany - - 2014
Risk factors for adverse outcome after extracorporeal life support (ECLS) are yet to be defined. For this purpose, we reviewed our institutional data from more than a decade, focusing on patients with ECLS. Between December 2001 and June 2013, 360 consecutive cardiac surgical patients received ECLS for post-cardiotomy cardiogenic shock, ...
Lavery Lawrence A LA Department of Plastic Surgery, University of Texas Southwestern, Dallas, TX, - - 2014
In a randomised, controlled study, we compared the efficacy of Grafix(®) , a human viable wound matrix (hVWM) (N = 50), to standard wound care (n = 47) to heal diabetic foot ulcers (DFUs). The primary endpoint was the proportion of patients with complete wound closure by 12 weeks. Secondary endpoints included the time to ...
Pekyavaş Nihan Özünlü NO Baskent University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Baglıca 06810, Ankara, Turkey. Electronic address: - - 2014
The purpose of our study was to investigate the effects of Kinesio Taping(®) Application with Complex Decongestive Therapy (CDT) in patients with lymphedema. 45 patients were randomly divided into 3 groups (CDT including Bandage, CDT including Bandage + Kinesio Tape(®), CDT including Kinesio Tape(®) without bandage). Assessments included the severity of the ...
Llaó Jordina J Hospital de la Santa Creu i Sant Pau (Barcelona), Universitat Autònoma de Barcelona, Catalonia, - - 2014
Oral corticosteroids remain the mainstay of treatment for moderately active ulcerative colitis (UC). In patients who fail to respond to oral corticosteroids, attempting the intravenous route before starting rescue therapies is an alternative, although no evidence supports this strategy. To evaluate clinical outcomes after a course of intravenous corticosteroids for ...
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