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Cho Jang-Eun JE Department of Anesthesiology and Pain Medicine, Anam Hospital, Korea University, Seoul, - - 2014
Prolonged duration of cardiopulmonary bypass aggravates the degree of inflammation and coagulopathy. We investigated the influence of 6% hydroxyethyl starch (HES) 130/0.4 on coagulation and inflammation compared with albumin when used for both cardiopulmonary bypass priming and perioperative fluid therapy in patients undergoing complex valvular heart surgery. Fifty four patients ...
Sartorius Danièle - - 2014
Aims and Objectives: We assessed the clinical impact of goal-directed coagulation management based on rotational thromboelastometry (ROTEM) in patients undergoing emergent cardiovascular surgical procedures. Materials and Methods: Over a 2-year period, data from 71 patients were collected prospectively and blood samples were obtained for coagulation testing. Administration of packed red ...
Pichler Renate R Department of Urology, Medical University of Innsbruck , Innsbruck , - - 2014
Abstract Objective. The aim of this study was to evaluate the clinical outcome after endoscopic therapy by injection of bulking agent in the treatment of occult vesicoureteral reflux (VUR) [no VUR on standard voiding cystourethrography (VCUG), but positive (99m)Tc-2,3-dimercaptosuccinic acid (DMSA) scan] in females who have recurrent febrile urinary tract ...
Elmaagacli A H AH Department of Hematology and Oncology, Helios Klinik Schwerin, Schwerin, - - 2014
GVHD is a major complication following allogeneic hematopoietic SCT, and is associated with substantial morbidity and mortality. Based on the results of our previous clinical study with females treated with human chorionic gonadotropin (hCG) as preconditioning therapy for in vitro fertilization, we hypothesized that low-dose hCG stimulates indoleamine-2,3-dioxygenase (IDO), IL ...
Manaqibwala Moiz I MI Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ, 08901, USA, - - 2014
Clopidogrel (Plavix(®)) may influence patient safety during fracture surgery. Our study examines the incidence of complications for patients undergoing hemiarthroplasty on clopidogrel therapy. All patients, who underwent hemiarthroplasty between 2005 and 2011 were retrospectively reviewed. Patients were placed in two comparative groups based on the use of clopidogrel antiplatelet therapy. ...
Liu Fen - - 2014
Currently, there is no consensus on the efficacy and resistance of de novo combination therapy versus monotherapy for treatment naive patients of chronic hepatitis B (CHB).Objectives: The aim of this study was to evaluate the effectiveness and resistance of de novo combination of lamivudine (LAM) and adefovir dipivoxil (ADV) compared ...
Fox Robert J RJ From the Mellen Center for Multiple Sclerosis (R.J.F.), Cleveland Clinic, OH; University of California San Francisco Multiple Sclerosis Center (B.A.C.C.); Hopital Civil (J.D.S.), Strasbourg, France; St. Josef Hospital (R.G.), Ruhr University, Bochum; Department of Neurology (H.-P.H.), Heinrich-Heine-University, Düsseldorf, Germany; The MS Center at Advance Neurology at Cornerstone Health Care (D.J.), Advance, NC; Departments of Neurology and Biomedicine (L.K.), University Hospital Basel, Switzerland; MS Center (M.K.), Carolinas Medical Center, Charlotte, NC; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs MS Center and Pediatric MS Center of Excellence (B.W.-G.), Jacobs Neurological Institute, Buffalo, NY; Infusion Communications (B.A.), Haddam, CT; and Biogen Idec Inc. (A.N., B.T., P.D.), Weston, - - 2014
Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) was a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week interruption of natalizumab. Eligible patients were relapse-free through the prior year on natalizumab and had no gadolinium-enhancing lesions on screening brain MRI. Patients were randomized ...
Reitan Christian C Department of Cardiology, Arrhythmia Clinic, Lund University, Skane University Hospital, Getingevägen, Lund S-221 85, - - 2014
Cardiac resynchronization therapy (CRT) has a well-documented positive effect on mortality and heart failure morbidity. The aim of this study was to assess the long-term survival and the predictive value of self-assessed functional status on the long-term prognosis of patients treated with CRT-pacemaker (CRT-P).METHODS AND RESULTS: Data were retrospectively collected ...
Sfoungaristos Stavros S Urology Department, Hadassah University Hospital, Jerusalem, Israel. Electronic address: - - 2014
To evaluate the impact of early hospital admission and onset of medical expulsive therapy (MET) in spontaneous passage of ureteral stones causing renal colic. We recruited 392 patients referred to the emergency room with symptoms of renal colic. All patients received standard MET of oral tamsulosin 0.4 mg at the time ...
Lee Min Geun MG Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea; Department of Internal Medicine, Hanmaeum Hospital, Jeju-si, - - 2014
The effect of platelet aggregation inhibitors (PAI) on post-endoscopic sphincterotomy (ES) bleeding in patients who cannot discontinue PAI for sufficient time in urgent conditions has not been identified. The present study analyzed the effect of sustained use of PAI on post-procedural bleeding in patients undergoing ES. A total of 762 ...
Takayanagi Shunsaku S Department of Neurosurgery, Aizu Chuo - - 2014
There are still few studies of low-dose recombinant tissue plasminogen activator (rtPA) therapy (0.6 mg/kg) for acute ischemic stroke (AIS) patients ≥ 80 years old, though most strokes occur in elderly people. The safety and effectiveness of this form of thrombolysis without endovascular therapy were evaluated in AIS patients ≥ ...
Aydin Ufuk U Department of Cardiovascular Surgery, Kocaeli Derince Training and Research Hospital, Kocaeli, - - 2014
ObjectivesLymphatic complications, lymphocele and lymphorrhea being the leading, are generally encountered after vascular interventions and surgeries. The present study aimed to evaluate the outcomes of vacuum-assisted-closure (VAC) therapy, which we frequently prefer as the first-choice treatment for such complications.Materials and methodsAmong patients undergoing peripheral vascular intervention or surgery between January ...
Waldron Nathan H NH From the Departments of *Anesthesiology and †Surgery, Duke University, Durham, North - - 2014
Goal-directed fluid therapy (GDFT) is associated with improved outcomes after surgery. The esophageal Doppler monitor (EDM) is widely used, but has several limitations. The NICOM, a completely noninvasive cardiac output monitor (Cheetah Medical), may be appropriate for guiding GDFT. No prospective studies have compared the NICOM and the EDM. We ...
Hoy Sheridan M SM Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand, - - 2014
Oral zonisamide (Zonegran(®)) is a benzisoxazole derivative chemically unrelated to other antiepileptic drugs (AEDs). It is approved in the EU as an adjunct to other AEDs in the treatment of pediatric patients aged ≥6 years with partial seizures, with or without secondary generalization. In a randomized, double-blind, multinational, phase III study ...
Jiang L L Liver Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China, - - 2014
Many advanced hepatocellular carcinoma (HCC) cases can be successfully downstaged into the Milan criteria; however, immediate radical therapy cannot be applied to all such patients for various reasons. Of the patients who are not eligible for immediate radical therapy, some accept repeated downstaging therapies and some undergo persistent observation. The ...
Osinusi-Adekanmbi Olukemi O Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, - - 2014
There is limited information on efficacy and durability of second-line antiretroviral therapy (2NL) beyond 12 months in resource-limited settings. A total of 73 patients were enrolled into a prospective 2NL observational cohort in Nigeria. Second-line antiretroviral therapy consisted of lopinavir/ritonavir plus nucleoside reverse transcriptase inhibitors. Time on 2NL ranged from ...
Nguyen V V Liverpool Hospital, Sydney, NSW, - - 2014
Antepartum anti-viral therapy (AVT) is often administered to prevent perinatal transmission of hepatitis B virus (HBV) infection. Little is known about the effect of AVT on post-partum flare rates and severity. To examine whether extending AVT beyond birth influences the post-partum course. One hundred and one pregnancies in 91 women ...
Elderwy Ahmad A AA Pediatric Urology, Assiut University Hospital, Assiut University, Assiut, - - 2014
We prospectively evaluated the efficacy of dissolution therapy and standard shock wave lithotripsy as a noninvasive modality for radiolucent renal stones in children. A total of 87 children with radiolucent renal calculi were included in study. Median age was 2.5 years (range 0.5 to 13). Computerized tomography was done to ...
Saxena V V University of California San Francisco, San Francisco, CA, - - 2014
Risks and benefits of protease inhibitor (PI) (telaprevir or boceprevir) triple therapy in hepatitis C virus (HCV)-infected patients with mildly decompensated cirrhosis, including those wait-listed for liver transplantation (LT), are incompletely known. To assess virological responses and safety of PI triple therapy in patients with mildly decompensated Child-Pugh (CP) CP ...
Karam Jose A JA Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, - - 2014
● To evaluate the feasibility, safety, pathologic, radiologic and functional outcomes of salvage surgery after prior renal mass ablation therapy. ● After IRB approval, we reviewed our renal tumor database, and described characteristics and outcomes of patients who experienced a local recurrence after energy ablation for renal masses, and underwent ...
Ioffe Yevgeniya Jane Mikhailovna YJ *Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and Departments of †Radiology, ‡Statistics, and §Radiation Oncology, Washington University in St Louis School of Medicine, St Louis, - - 2014
Intensity-modulated radiation therapy (IMRT) is frequently utilized in the treatment of cervical cancer. Our study compared instances of pelvic fractures, osteonecrosis, and osteomyelitis posttreatment with conventional radiation therapy (RT) versus IMRT in patients with cervical carcinomas. Eighty-three patients primarily treated with IMRT were case matched with 83 historical control subjects ...
Sames-Dolzer Eva E Department of Cardiothoracic and Vascular Surgery, General Hospital Linz, Linz, - - 2014
The Norwood procedure is commonly used as first-step palliation in children with hypoplastic left heart syndrome or related congenital malformations. In most cases, the operation is carried out during the first week of life. Excessive pulmonary blood flow in univentricular physiology can soon lead to compromised cardiac function and pulmonary ...
Parodi Guido G The Invasive Cardiology, Careggi Hospital, Florence, - - 2014
There are very few clinical data concerning the safety of switching from clopidogrel to prasugrel in patients undergoing coronary stenting. However, in the daily activity, clinicians face the decision of switching patients at high-risk of thrombotic events from clopidogrel to prasugrel. Thus, we sought to evaluate clinical events in patients ...
Lardizabal Joel A JA The Multi-Disciplinary Structural Heart Disease Program of the University of Miami - Miller School of Medicine, Miami, - - 2014
OBJECTIVE. We explored the efficacy, safety, and clinical consequences of on-label and off-label TAVR in the real-world setting. BACKGROUND. The transcatheter heart valve (THV) was initially approved only for transfemoral (TF) delivery (on-label use) during transcatheter aortic valve replacement (TAVR) in inoperable patients with severe aortic stenosis. Because of lack ...
Varvyanskaya Anastasia A Ear, Nose, and Throat (ENT) Clinic, Sechenov First Moscow State Medical University, Moscow, - - 2014
This study assessed efficacy of clarithromycin "long-term" macrolide therapy as an adjunct to maintenance therapy with nasal corticosteroids to prevent recurrence of nasal polyps (NP) after functional endoscopic sinus surgery (FESS). A total of 66 patients with chronic rhinosinusitis and bilateral NP were randomized into 3 study arms, 22 patients ...
Hirayama Atsushi A Division of Cardiology, Department of Medicine, Nihon University School of - - 2014
Background: YUKAWA is a 12-week, randomized, double-blind, placebocontrolled, phase 2 study evaluating the efficacy and safety of evolocumab (AMG 145) in statin-treated Japanese patients at high cardiovascular risk. Methods and Results: 310 eligible patients receiving stable statin (±ezetimibe) therapy were randomized to 1 of 6 treatments: placebo every 2 weeks (Q2W) or ...
Maduell F F Departments of Nephrology and Renal Transplantation, Hospital Clínic Barcelona, Barcelona, - - 2014
Background: Unlike conventional hemodialysis treatments, which rely almost solely on diffusion-related mechanisms for solute removal, hemodiafiltration (HDF) allows more efficient removal of higher molecular weight toxins due to convective transport mechanisms. To facilitate the removal of these toxins in HDF treatment modalities, dialyzers with highly efficient high-flux membranes are necessary. ...
Hutcheson Katherine A KA Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1445, Houston, TX, 77030, USA, - - 2014
Summarize functional outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal cancer (OPC). A systematic review was conducted. The MEDLINE database was searched (MeSH terms: TORS, pharyngeal neoplasms, oropharyngeal neoplasms). Peer-reviewed human subject papers published through December 2013 were included. Exclusion criteria were as follows: (1) case report design (n < 10), ...
He L-Y LY Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, - - 2014
Chinese herbal medicine Jinlianqingre Effervescent Tablets (JET) are the recommended control measure for uncomplicated hand, foot, and mouth disease (HFMD) by the Ministry of Health of China. However, high-quality evidence to support this recommendation is limited. A total of 288 patients ranging in age from 1 to 13 years were randomly ...
van der Veen Erwin L EL Department of Otorhinolaryngology, Central Military Hospital, Utrecht, The - - 2014
In this rapid systematic review, we studied the clinical question, What is the effect of hyperbaric oxygen therapy on hearing thresholds in patients who suffered a recent acute acoustic trauma? After screening for eligible titles and abstracts and extracting duplicates, 6 original research papers could be found. The general methodology ...
Lamore Raymond F RF 3rd Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, - - 2014
IMPORTANCE High-dose glucocorticoids (GCs) are routinely given to surgical patients with a history of GC exposure to prevent perioperative acute adrenal insufficiency, but this practice is not well supported. OBJECTIVE To evaluate the variability of perioperative GC dosing among patients with inflammatory bowel disease (IBD) undergoing major abdominal surgery. DESIGN, ...
Jackson Christian S CS Division of Gastroenterology, Loma Linda VA Medical Center, Loma Linda, California, - - 2014
OBJECTIVES:Gastrointestinal angiodysplastic lesions (GIADs) are defined as pathologically dilated communications between veins and capillaries. The objective of this systematic review and meta-analysis was to determine the efficacy of available treatment modalities for GIADs.METHODS:We identified eligible studies by searching through PubMed, SCOPUS, and Cochrane central register of controlled trials. We searched ...
Fernández-Ruiz Mario M Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Hospital "12 de Octubre" (i+12), Madrid, - - 2014
Background. Concerns have arisen regarding the optimal antifungal regimen for Candida parapsilosis bloodstream infection (BSI) in view of its reduced susceptibility to echinocandins. Methods. The CANDIPOP Study is a prospective multicenter population-based surveillance program on Candida BSI conducted through a 12-month period in 29 Spanish hospitals. Clinical isolates were identified by DNA ...
Benhamed Lotfi L Department of Thoracic and Vascular Surgery, Valenciennes Hospital, Valenciennes, - - 2014
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether adjuvant antifungal therapy is useful after pulmonary surgery for aspergilloma. One hundred and sixteen papers were identified using the search described below, of which 5 papers presented the best evidence to ...
Brynskov Troels T *Department of Ophthalmology, Copenhagen University Hospital Roskilde, Roskilde, Denmark; and †Faculty of Health Sciences, University of Copenhagen, Copenhagen, - - 2014
To evaluate the efficacy and safety of intravitreal ranibizumab for branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) in daily clinical practice. A prospective study enrolling all patients diagnosed with BRVO or CRVO who received intravitreal ranibizumab therapy at our department. Fifty-seven patients had BRVO and 49 ...
Addison Christina L CL Division of Medical Oncology, Ottawa Hospital Cancer Centre, 501 Smyth Road, Box 912, Ottawa, ON, K1H 8L6, - - 2014
The optimal frequency of intravenous (IV) bisphosphonate administration is unclear. We thus performed a study evaluating the effects of switching from 3-4 to 12 weekly therapy in patients with biochemically defined low-risk bone metastases. Patients with serum C-telopeptide (CTx) levels ≤600 ng/L after ≥3 months of 3-4 weekly IV pamidronate were switched ...
Greaves M M College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United - - 2014
All anticoagulants increase the risk of bleeding, including fatal bleeds. Oral anticoagulants are in widespread use for long-term therapy because of their efficacy in reducing systemic thromboembolism, particularly ischaemic stroke in subjects with atrial fibrillation, and in protection from recurrent venous thromboembolism (VTE) after a first apparently unprovoked event. The ...
Ramanathan Ramnath Santosh - - 2014
To review our experience using methotrexate as a single long-term immunosuppressant (IS) therapy in neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD). We performed a retrospective chart review of all patients with a diagnosis of NMO/NMOSD, supported by a positive NMO-IgG testing, who were treated with methotrexate. A paired sample 2 tailed ...
Wallace Richard J RJ Jr The Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, 11937 U.S. Hwy 271, Tyler, TX 75708, - - 2014
We report the largest clinical experience using tigecycline-containing regimens for salvage treatment of patients with Mycobacterium abscessus and Mycobacterium chelonae. Data were collected from 52 patients on emergency/compassionate use (n = 38) or two open-label studies (n = 7 patients each). Based on information that was available, 46 (88.5%) of the subjects received antibiotic ...
Komatsu Takashi T Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine, Iwate Medical - - 2014
It remains unclear if the CHADS2 score or CHA2DS2-VASc score is more useful for the risk stratification of ischemic stroke/systemic thromboembolism in Japanese patients with non-valvular paroxysmal atrial fibrillation (NVPAF).We retrospectively investigated the incidence of ischemic stroke on the basis of CHADS2 and CHA2DS2-VASc scores in 332 NVPAF patients (224 ...
Yokoi Hiroyoshi H Department of Cardiology, Kokura Memorial - - 2014
Carotid intima-media thickness (IMT), a measure of atherosclerosis, is modulated by multiple risk factors. Accordingly, comprehensive control of risk factors is indispensable for management of atherosclerosis. In this study, as a posthoc analysis of the JART Study we planned two analyses. In the main analysis, we evaluated the effect of ...
Zabana Yamile Y Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), - - 2014
Thiopurines prevent Crohn's disease (CD) endoscopic recurrence (ER) at least in 50% of patients one year after surgery. To evaluate the value of adding mesalazine in patients with subclinical ER despite preventive thiopurine therapy. CD patients with ileocecal resection treated with thiopurines for post-surgical recurrence prevention in whom mesalazine was ...
Lee C H CH Department of Pathology and Molecular Medicine, McMaster University, St Joseph's Healthcare, 50 Charlton Avenue East, 424 Luke Wing, Hamilton, ON, L8N 4A6, Canada, - - 2014
Clostridium difficile infection (CDI) is one of the most frequent causes of healthcare-associated infections, and its rates are also increasing in the community. The management of CDI has become a major challenge, given growing rates of recurrences and failures with standard antibiotic therapy. Mounting evidence suggests that fecal microbiota transplantation ...
Izumi Namiki N Musashino Red-Cross Hospital, Tokyo, Japan, - - 2014
Efficacy of available therapies for patients with HCV who have previously failed treatment is limited. Two Phase III, open-label trials in Japan investigated efficacy and safety of simeprevir and peginterferon-α-2a/ribavirin (PR) combination therapy in treatment-experienced patients with genotype 1 HCV infection. In CONCERTO-2, prior non-responders to IFN-based therapy (N = 106) received ...
Ma Dan D Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of - - 2014
Behcet's disease (BD) accompanied by intestinal involvement is called intestinal BD. Although recent studies have attained positive feedback with the administration of anti-TNF-α agents in patients with BD, only a few reports on the study of etanercept in intestinal BD have been found. In this study, 35 cases of intestinal ...
Kato K K Division of Research Planning and Development, Nihon University School of Medicine, Tokyo, - - 2014
We previously demonstrated that antibiotic combination therapy is effective for induction and maintenance of ulcerative colitis (UC) remission. To assess whether antibiotic combination therapy is effective for active UC refractory to or dependent on steroids in a multicentre, open-label trial. We enrolled 30 patients with steroid-refractory and 64 with steroid-dependent ...
Vanicek J J Department of Diagnostic Imaging, St Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech - - 2014
Objective: Large artery occlusion (LAO) in patients with major stroke predicts poor revascularization by intravenous thrombolysis (IVT) and more likely results in a poor outcome. We focused on the effects of intra-arterial thrombolysis (IAT) and endovascular mechanical recanalization (EMR) as rescue therapies in major strokes refractory to IVT. Methods: A ...
Camenzind Edoardo E University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, - - 2014
To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES). Of 8709 patients in PROTECT, 4357 were randomized to E-ZES and 4352 to C-SES. Aspirin was ...
Sitbon Olivier O Faculté de Médecine, Le - - 2014
Patients with severe pulmonary arterial hypertension (PAH) in New York Heart Association (NYHA) functional class (FC) III/IV have a poor prognosis, despite survival benefits being demonstrated with intravenous epoprostenol. In this pilot study, the efficacy and safety of a triple combination therapy regimen in patients with severe PAH was investigated.Data ...
Shiner Christine T CT 1Neuroscience Research Australia and the University of New South Wales, Sydney, - - 2014
Motor deficits after a stroke are thought to be compounded by the development of asymmetric interhemispheric inhibition. Bilateral priming was developed to rebalance this asymmetry and thus improve therapy efficacy. This study investigated the effect of bilateral priming before Wii-based Movement Therapy to improve rehabilitation after stroke. Ten patients who ...
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