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Merola Aristide A Department of Neuroscience, University of Turin, Via Cherasco 15, 10124, Turin, Italy, - - 2014
This observational study reports the long-term follow-up of 184 Parkinson's disease (PD) patients treated with subthalamic deep brain stimulation (STN-DBS), retrospectively analyzing the outcomes of subjects with pre-surgical mild cognitive impairment (MCI) compared to those of patients with normal cognition. Patients were divided into PD-MCI or normal cognition groups at ...
Jiang Yawen Y Department of Clinical Pharmacy, Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Schaeffer Center for Health Policy and Economics, University Park Campus, UGW-Unit A, Los Angeles, CA, 90089-7273, USA, - - 2014
Ziprasidone is increasingly used for the treatment of schizophrenia and bipolar disorder. The purpose of this study was to compare healthcare costs and use associated with ziprasidone and olanzapine. Ziprasidone and olanzapine treatment episodes of schizophrenia and bipolar disorder patients were identified in the 01/2007-12/2010 IMS LifeLink™ Database. The period ...
Atkins Susan - - 2014
Depot antipsychotic injections are an important tool for the management of patients with schizophrenia who have difficulty with adherence to oral medication. However, pain and discomfort at the injection site can be a potential impediment to the use of these long-acting formulations. We report here the results of a pooled ...
Williams Richard R Vancouver Island Health Authority, Victoria, BC, - - 2014
To assess outcomes over 24 months in Canadian patients with schizophrenia initiated on risperidone long-acting injection (RLAI) and participating in the electronic Schizophrenia Treatment Adherence Registry (e-STAR). Patients with schizophrenia or schizoaffective disorder were enrolled from 24 sites after an independent decision to initiate RLAI. Subsequent patient management was based ...
Warikoo Nisha N Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
Despite a large body of evidence, the issue of differences in adherence and continuation of treatment with first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) in schizophrenia remains unresolved. This study compared adherence and continuation of treatment between patients on SGAs and FGAs and examined the influence of several socio-demographic and ...
Ahmadkhaniha Hamid-Reza HR Assistant Professor, Department of Psychiatry, Mental Health Research Center, Tehran Psychiatry Institute, Tehran University of Medical Sciences and Health Services, Tehran, - - 2014
Objective: The present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, SDAs) and depot preparation of conventional (typical) antipsychotics. Methods: In this historical cohort study, mean relapse per month (MRM) index, duration between initiation of antipsychotic treatment and ...
Huang Shiau-Shian - - 2013
OBJECTIVE The authors compared the efficacy of long-acting injectable antipsychotics and oral antipsychotics on rehospitalization rate of community-dwelling patients with schizophrenia who had frequent admissions. METHODS The cohort study of 14,610 patients was conducted by analyzing the Taiwan National Health Research Institutes data. The patients were divided into groups that ...
Midbari Yael - - 2013
Abstract Objective: There are very few studies in the literature regarding clozapine use in children <13 years of age. In this retrospective chart review, we compared the safety of clozapine - as determined by hematological and cardiometabolic changes - to that of non-clozapine antipsychotics used in the treatment of childhood-onset ...
Attard A - - 2013
To follow-up patients prescribed paliperidone palmitate long-acting injection (PP) over 1 year to determine factors predicting continuation with PP treatment. Naturalistic observation of patients registered as starting PP in a single healthcare unit in London, UK. Monovariate and multivariate (Cox regression) analysis of factors predicting continuation at 1 year. Data were available ...
Aykut Koray - - 2013
In elderly patients with mild cognitive impairment, noncompliance with respiratory exercises, ineffective expectoration, reluctance in mobilization, and difficulty in learning the use of drugs such as inhalers were observed in the early postoperative period after coronary artery bypass graft surgery. It was hypothesized that respiratory complications may be more frequent ...
Naber Dieter - - 2013
This randomised 12-month open study analysed the effectiveness of quetiapine XR (400-800mg) versus risperidone (2-6mg) on subjective well-being in schizophrenia (NCT00600756). Primary objective was to demonstrate non-inferiority of quetiapine XR to risperidone in 6-month responder rate using the Subjective Well-Being under Neuroleptics scale (SWN-K) (per-protocol at Month 6 [PP 6] ...
Chien Wai Tong - - 2013
OBJECTIVE This study was conducted to test the effects of a nine-month family-led peer support group for Chinese people with schizophrenia in Hong Kong over a three-year follow-up and to compare outcomes with those of psychoeducation and standard psychiatric outpatient care. METHODS A randomized controlled trial of 106 Chinese families ...
Divakaran Anjith A Department of Psychiatry and Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, - - 2013
This study aims at examining "parent-of-origin effect" (POE) in dermatoglyphic patterns among patients with schizophrenia and non-affective psychoses. Dermatoglyphic comparison was carried out for schizophrenia patients (n=200) and healthy controls (HC) (n=100). In addition, the effect of family history and POE was examined in the dermatoglyphic pattern. Schizophrenia patients compared ...
Uchida Takahito - - 2013
Long-term follow-up data of patients with schizophrenia on depot antipsychotics have been few and the longest follow-up period has been up to 7 years. We carried out a systematic chart review to examine 10-year outcomes for outpatients with schizophrenia who were receiving a conventional depot antipsychotic. Maintenance of outpatient status ...
Hong Jihyung - - 2013
OBJECTIVE: This study assessed the impact of depot formulations on adherence and treating costs in the naturalistic treatment of previously non-adherent outpatients with schizophrenia. METHODS: Data were taken from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Medication adherence and treating costs during an 18-month follow-up were assessed and compared ...
Trives Mehdi Ziadi - - 2013
We sought to assess the effect of the addition of a fixed dose of 5 mg daily of aripiprazole on hyperprolactinemia induced by risperidone long-acting injectable (RLAI) treatment in patients with chronic psychoses and the adverse events related to the addition of aripiprazole and its impact on the disease.This is ...
Hui Christy L-M - - 2013
Objective:Relapses in psychosis are costly and may have irreversible consequences. Relapse prevention is thus critical in the treatment of schizophrenia. Apart from medication discontinuation, a consistent relapse predictor has not been identified due to limitations in previous studies. We aim to investigate relapse predictors in a large cohort of patients ...
Suzuki Yutaro - - 2013
OBJECTIVE: We examined sex differences in the effect of olanzapine (OLZ), risperidone (RIS), aripiprazole (ARP), or quetiapine (QTP) on mean corrected QT (QTc) intervals among 222 patients with schizophrenia. METHODS: Subjects were patients with schizophrenia who were treated with either OLZ (n = 69), RIS (n = 60), ARP (n = 62), or QTP (n = 31). Electrocardiographic ...
Chung S-D - - 2013
BACKGROUND: No prior study has investigated the possibility that scabies patients may be at an increased risk for developing pemphigoid. OBJECTIVE: To evaluate the risk of pemphigoid following scabies during a 3-year follow-up period using a Taiwanese population-based claims database and taking clinical and demographic characteristics into consideration. METHODS: This ...
Nakamura Mitsuhiro - - 2013
Differences in effectiveness between haloperidol injection and oral atypical antipsychotics in the acute-phase treatment of schizophrenia are not well examined. We retrospectively investigated whether these treatment options affected the length of mechanical restraint. We used the Japanese Diagnosis Procedure Combination Database to identify schizophrenia patients who were involuntarily hospitalized and ...
Bitter István - - 2013
We conducted a nationwide, full-population based investigation to evaluate the comparative effectiveness of all marketed second generation antipsychotic drugs (SGA) prescribed for outpatients with the diagnosis of schizophrenia in Hungary. Using the national central register, our observational follow-up study included all patients with schizophrenia or related disorder between 01/01/2006 and ...
Monteiro Fabíola P - - 2013
The 22q11.2 deletion is the most frequent interstitial deletion in humans and presents a wide phenotypic spectrum, with over 180 clinical manifestations described. Distinct studies have detected frequencies of the deletion ranging from 0 % to 75 %, depending on the studied population and selection criteria adopted. Due to the lack of ...
Kanahara Nobuhisa - - 2013
Although the duration of untreated psychosis (DUP) plays an important role in the short-term prognosis of patients with schizophrenia, their long-term prognosis generally is not determined by DUP alone. It is important to explore how other clinical factors in the early stage are related to DUP and consequent disease courses. ...
Ciudad Antonio - - 2013
A considerable proportion of patients suffering from schizophrenia show suboptimal responses to oral antipsychotics due to inadequate adherence. Hence, they are likely to benefit from switching to a long-acting injectable formulation. These post hoc analyses assessed the clinical effects of switching to olanzapine long-acting injection (OLAI) from either oral olanzapine ...
Cechnicki Andrzej - - 2012
BACKGROUND: The level of expressed emotions in the family (EE) and components thereof (emotional over-involvement EOI, and critical comments CC) have been found to be related to treatment outcomes in psychotic patients. One point of interest is the dynamic of various outcomes in relation to initial EE, CC and EOI ...
Bayram Huseyin - - 2012
BACKGROUND: In the present study, we aimed to investigate the effects of off-pump coronary artery bypass grafting and on-pump cardiopulmonary bypass on the serum S-100 beta (S-100B) protein levels and neurocognitive functions of the patients. MATERIALS AND METHODS: Sixty-four patients undergoing coronary artery bypass grafting (CABG) were enrolled in the ...
Stargardt Tom - - 2012
This study investigates the effectiveness and cost of typical versus atypical antipsychotics in a nationwide German cohort of patients with schizophrenia. The study sample consisted of patients insured with 4 sickness funds (n = 8,610) who were followed up for 12 months after hospital discharge with a diagnosis of schizophrenia ...
Lazibat Ines - - 2012
The purpose of our study was to investigate the association between perioperative cerebral microembolization, expressed as high-intensity transient signals (HITS) and postoperative dynamics of the neuromarker S100P in patients operated using cardiopulmonary bypass, and to assess their impact upon the neurocognitive function in the early postoperative stage. The study involved ...
Takahashi Sakae - - 2012
Blonanserin is a relatively new atypical antipsychotic drug, and has been used in Korea and Japan for 1 and 3 years, respectively. Therefore, the clinical characteristics of blonanserin remain unclear. In this study, to clarify the features of blonanserin, we performed prospective and long-term comparative investigations of patients treated with ...
Rangaswamy Thara - - 2012
To determine the 25 year follow-up of subjects originally enrolled in the Study of factors associated with course and outcome of schizophrenia (SOFACOS) at Chennai. All subjects who were followed up were administered the same research tools which were done at inclusion, namely the PSE & PPHS. At the end ...
Clemmensen Lars - - 2012
The current review analyzes the long-term outcome and prognosis of early onset schizophrenia based on previously published studies in 1980. A systematic search of articles published in the English-language literature after 1980 identified a total of 21 studies, which included 716 patients who were either suffering from early onset schizophrenia ...
Kasanuki Koji - - 2011
We performed a quantitative neuropathological examination of the hypometabolic regions on FDG PET in dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and control cases. When the DLB cases were divided into two groups according to concomitant AD pathology (ADP), neuronal loss in the temporo-parietal association area was milder in ...
Li Fangcai - - 2011
Forty-six patients with degenerative lumbar scoliosis, and treated with selective segmental transforaminal lumbar interbody fusion (TLIF), were studied retrospectively. To investigate the surgery outcomes of the posterior-only approach with selective segmental TLIF for the treatment of degenerative lumbar scoliosis. Degenerative lumbar scoliosis usually occurs late in the life of patients ...
Dalal Aliasgar - - 2011
Retrospective radiographic outcome analysis. To compare residual postoperative apical vertebral rotation between uniplanar versus polyaxial bilateral pedicle screw constructs in thoracic adolescent idiopathic scoliosis (AIS). Vertebral rotation is a component of the 3-dimensional deformity of AIS. The correction of vertebral rotation is an important goal of surgery. A comparison of ...
Denuncio Pablo - - 2011
Plastic debris (PD) ingestion was examined in 106 Franciscana dolphins (Pontoporia blainvillei) incidentally captured in artisanal fisheries of the northern coast of Argentina. Twenty-eight percent of the dolphins presented PD in their stomach, but no ulcerations or obstructions were recorded in the digestive tracts. PD ingestion was more frequent in ...
Smith Justin S - - 2011
Retrospective review of a prospective, multicenter database. The purpose of this study was to assess whether elderly patients undergoing scoliosis surgery had an incidence of complications and improvement in outcome measures comparable with younger patients. Complications increase with age for adults undergoing scoliosis surgery, but whether this impacts the outcomes ...
Lee Chong Suh - - 2011
A retrospective study. To determine whether angular mismatch between the vertebral endplate and prosthetic endplate during lumbar total disc replacement (L-TDR) affects the radiological and clinical outcomes. A prosthesis anchored to the vertebral body by using a large central keel carries an inherent risk of angular mismatch between the vertebral ...
Zhang Hong - - 2011
Unilateral pedicle screw epiphysiodesis of the neurocentral synchondrosis (NCS) can produce asymmetric growth of the synchondrosis to create scoliosis in an immature animal model. We asked whether a preexisting experimentally created scoliosis could be limited and corrected by modulating the growth of the faster-growing NCS by a similar method. Nine ...
Scholz M - - 2011
Several studies suggest fusion rates are higher with anterior cervical discectomy and fusion procedures if supplemented with a plate. However, plates may be associated with higher postoperative morbidity and higher rates of dysphagia. This led to the development of a cervical stand-alone cage with integrated fixation for zero-profile segmental stabilization. ...
Djurasovic Mladen - - 2011
STUDY DESIGN.: Retrospective cohort analysis. OBJECTIVE.: To investigate health-related quality of life improvements in patients undergoing lumbar fusion to revise a previous lumbar spine surgery. SUMMARY OF BACKGROUND DATA.: Spinal fusion is often used as a surgical intervention in patients who have previously undergone lumbar surgery. Prior studies suggest results ...
Chen Hong - - 2011
A retrospective study. To analyze and compare the sagittal spinopelvic alignment variation after implantation of purely dynamic and hybrid pedicle screw-based stabilization systems, seeking for its clinical implication. Numerous studies have investigated the kinematic features of pedicle screw-based dynamic stabilization systems since their clinical application. However, there is a lack ...
Moon Eun Su - - 2011
retrospective comparative study (Level III). to compare the operative results of posterior fusion and a 2-stage anterior L5-S1 fusion followed by posterior fusion in neuromuscular scoliosis patients with significant pelvic obliquity (PO). PO in neuromuscular scoliosis is common and a challenging problem that affects proper sitting balance, necessarily addressing the ...
Newton Peter O - - 2011
in vivo analysis in an immature porcine model. to evaluate the effect of intraoperative tensioning of an anterolateral flexible spinal tether on growth modulation manifested as deformity creation, disc response, spinal motion, and screw fixation using radiographs, computed tomography, magnetic resonance imaging, biomechanical testing, and histology. spinal growth modulation using ...
Singh Pankaj - - 2011
Vertebral hemangiomas (VH) are the most common lesions of the vertebral column. To evaluate the role of intraoperative ethanol embolization, surgical decompression, and instrumented fusion in VH presenting with myelopathy. This is was a prospective study of single-level symptomatic VH with cord compression. Exclusions were as follows: pathological fractures, deformity, ...
Ravi Bheeshma - - 2011
Clinical case series. The primary objective of this study was to evaluate the clinical accuracy of computer-assisted two-dimensional fluoroscopy (2D-CAS) for the percutaneous placement of lumbosacral pedicle screws. Loss of visual anatomic landmarks and reduced tactile feedback increases the risk of pedicle screw misplacement by when using minimally invasive (MIS) ...
Jalanko Tuomas - - 2011
A retrospective comparative study of prospectively collected data. To compare clinical, radiographic, and health-related quality of life (Scoliosis Research Society [SRS]-24) outcomes in patients undergoing hemivertebra excision by simultaneous anteroposterior (AP) or posterolateral only approach (PL). AP hemivertebra resection for congenital scoliosis has provided reliable and safe long-term outcomes with ...
Roland Gerstmeier - - 2011
An "Orthrius-group" of genera is proposed, and defined to include Aphelochroa Quedenfeldt, 1885; Caridopus Schenkling, 1908; Dozocolletus Chevrolat, 1842; Gyponyx Gorham, 1883; Languropilus Pic, 1940; Orthrius Gorham, 1876; Pieleus Pic, 1940; Xenorthrius Gorham, 1892; plus three new genera Neorthriusgen. n., Nonalatusgen. n. and Pseudoastigmusgen. n. A phylogeny of the 11 ...
Sarlak Ahmet Yilmaz - - 2010
Retrospective study. To evaluate the radiologic results of fusion with segmental pedicle screw fixation in neglected thoracic congenital curves with a mean follow-up of 51.3 months (range: 24 to 108 mo). Segmental pedicle screw fixation has been shown to be effective both in correcting and controlling the idiopathic spinal deformities. ...
Bae Jun Seok - - 2010
Although favorable clinical outcomes have been reported for instrumented lumbar interbody fusion (LIF), adjacent segment degeneration (ASD) has been reported as a long-term complication after LIF. To investigate ASD after instrumented LIF performed at a single level and only for the homogeneous disease of adult low-grade isthmic spondylolisthesis. A total ...
Greggi Tiziana - - 2010
Retrospective case series review. To compare two similar groups of adolescents surgically treated for their spinal deformity either by posterior segmental fusion alone (PSF) or by posterior spinal fusion and thoracoplasty (PSF+T); attention was focused on the long-term effects of thoracoplasty on pulmonary function in the surgical treatment of adolescent ...
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