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Witte Philip G PG Southern Counties Veterinary Specialists, Ringwood, United - - 2014
To report clinical experiences with tibial plateau leveling osteotomy (TPLO) to address cranial cruciate ligament (CCL) disease in small breed dogs with high tibial plateau angles (TPA) using a specific 4-hole locking T-plate. Retrospective case series. Small breed dogs (<15 kg) with high TPA (>30°): n = 19 (29 CCL ruptures). TPLO was ...
Bertone Alicia L AL Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH - - 2014
Objective-To evaluate intra-articular autologous protein solution (APS) for the treatment of osteoarthritis in horses. Animals-40 client-owned horses with naturally occuring osteoarthritis. Procedures-APS was generated from a dual-device system that concentrated plasma and WBC proteins and enriched platelet growth factors. Horses were randomly assigned to receive an intra-articular injection of 5 ...
Le Mar Karen Jane KJ Health Care Development, Midcentral District Health Board, Palmerston North, New - - 2013
To identify preoperative risk factors that potentially affect postoperative length of stay of patients undergoing total hip replacement. With limited health resources and an ageing population, alongside an increasing prevalence of osteoarthritis and the growing need for total hip replacement, reducing length of stay is a mainstay of effective and ...
Holler P J PJ Clinic of Small Animal Medicine, LMU University, Munich, - - 2014
E-point-to-septal-separation (EPSS) and the sphericity index (SI) are echocardiographic parameters that are recommended in the ESVC-DCM guidelines. However, SI cutoff values to diagnose dilated cardiomyopathy (DCM) have never been evaluated. To establish reference ranges, calculate cutoff values, and assess the clinical value of SI and EPSS to diagnose DCM in ...
Sullivan Sheena G - - 2013
Methadone maintenance treatment (MMT) in China was established in 2004. The purpose of the present study was to estimate client retention and identify client factors associated with longer times in treatment. Data were abstracted from the MMT Data System from April 2008 to March 2010. Clients were considered to have ...
Macdonald Tamara L - - 2013
This prospective study evaluated the effect of tibial tuberosity advancement (TTA) on lameness, thigh circumference, range of motion (ROM), and radiographic osteoarthritis (OA) scores at 6 wk, 6 mo, and 1 y after surgery in 24 client-owned dogs with cranial cruciate ligament (CrCL) deficiency. Complications associated with TTA were also ...
Christopher Scott A - - 2013
OBJECTIVE: To evaluate long-term (>1 year) outcomes with respect to function and complications in dogs undergoing TightRope (TR), tibial plateau leveling osteotomy (TPLO), or tibial tuberosity advancement (TTA) for treatment of cranial cruciate ligament (CCL) disease. STUDY DESIGN: Retrospective clinical cohort study. METHODS: Medical records from 2006 to 2009 were ...
Bentley Adrienne M - - 2013
OBJECTIVE: To characterize derangements in the hemostatic profiles of dogs with naturally occurring septic peritonitis and determine if such derangements were predictive of survival. DESIGN: Prospective, observational single cohort study. SETTING: University veterinary teaching hospital. ANIMALS: A total of 27 client-owned dogs with naturally occurring septic peritonitis. INTERVENTIONS: Standard treatment ...
Liebenberg C - - 2012
BACKGROUND: Babesiosis in dogs is associated with severe thrombocytopenia; yet infected dogs rarely show clinical signs of hemorrhage. HYPOTHESIS: Dogs with uncomplicated babesiosis have normal hemostatic capacity despite severe thrombocytopenia. ANIMALS: Nineteen client-owned dogs with uncomplicated babesiosis; 10 healthy controls. METHODS: A prospective, cross-sectional, observational study. Thromboelastography (TEG), prothrombin time ...
Zoia Andrea - - 2012
Objective-To determine whether dogs with ascites secondary to right-sided congestive heart failure (CHF) have bleeding disorders associated with hypofibrinogenemia and discordant plasma fibrin-fibrinogen degradation products (FDPs) and D-dimer assay results (ie, a circulating concentration of FDPs higher than the reference range and a circulating concentration of D-dimer within the reference ...
Fang Wen-tong - - 2012
Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia, and AF is associated with relatively higher all-cause mortality in both men and women. However, there are limited treatment options for AF. Statins are hypothesized to have a benefit against arrhythmias in addition to well-established secondary prevention benefit for ...
Mortensen Eric M EM VERDICT Research Program, and South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, USA. - - 2012
Studies suggest that statins and angiotensin-converting enzyme (ACE) inhibitors might be beneficial for the treatment of infections. Our purpose was to examine the association of statin, ACE inhibitor, and angiotensin II receptor blocker (ARB) use with pneumonia-related outcomes. We conducted a retrospective cohort study using Department of Veterans Affairs data ...
Mann Devin M DM Department of Medicine, Division of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02119, USA. - - 2013
Given the results of the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial, statin initiation may be considered for individuals with elevated high-sensitivity C-reactive protein (hsCRP). However, if followed prospectively, many individuals with elevated CRP may become statin eligible, limiting the impact ...
Warita Shunichiro - - 2012
Background: The aim of this prospective study was to determine whether statin therapy (pitavastatin) has a beneficial effect on the prevention of new-onset atrial fibrillation (AF) in elderly patients with hypertension (HTN) and to evaluate the relationships among statin treatment, the development of AF, and left atrial (LA) and ventricular (LV) ...
Tsai Nai-Wen - - 2012
BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their cholesterol-lowering effect. We investigated the effects of statins on serum hs-CRP level and clinical outcome of acute ischemic stroke (IS) patients. METHODS: This prospective cohort study consequently evaluated patients with acute IS in a single medical center. Serum hs-CRP levels were ...
Lee Stephen Wai Luen - - 2012
Background: While statin induces plaque regression, its effects, particularly with different doses on plaque virtual histology composition, remain unknown. Methods and Results: In this prospective, randomized, double-blinded study, 40 consecutive statin-naive patients with stable angina requiring percutaneous coronary intervention (PCI) were randomized to 2 arms (20 patients each) receiving 6 months of ...
Naji F - - 2012
Atrial fibrillation (AF) is the most common arrhythmia and one of the major causes of morbidity and hospitalization. It is an important risk factor for thromboembolic complications and cerebrovascular disease. In AF, extensive electrical and structural remodeling of atrial tissue takes place with the main underlying mechanisms being inflammation and ...
Buzková Helena - - 2012
CYP2C9*3 allele has been reported to correlate with increased plasma concentration of fluvastatin active form in healthy volunteers. We analyzed the correlation between the CYP2C9 genotype and cholesterol-lowering effect of fluvastatin in human hypercholesterolemic patients. The study was prospective, without any interventions to standard procedures of hypolipidemic treatment. CYP2C9 genotype ...
Capoulade Romain - - 2012
The aims of this study were to examine prospectively the relationship between metabolic syndrome (MetS) and aortic stenosis (AS) progression and to evaluate the effect of age and statin therapy on AS progression in patients with or without MetS. Despite the clear benefits of statin therapy in primary and secondary ...
Cougo-Pinto Pedro Telles - - 2012
Scarce data are available on the occurrence of symptomatic intracranial hemorrhage related to intravenous thrombolysis for acute stroke in South America. We aimed to address the frequency and clinical predictors of symptomatic intracranial hemorrhage after stroke thrombolysis at our tertiary emergency unit in Brazil. We reviewed the clinical and radiological ...
de Céniga Melina Vega - - 2012
Abdominal aortic aneurysm (AAA) is significant health problem in the elderly. Efforts to limit the mortality rate depend on early detection and elective AAA repair. The benefit of early detection of AAAs, by ultrasound screening is limited since early repair of small AAA has been shown to provide no clinical ...
Höglund Niklas - - 2012
BACKGROUND: The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180days after CV. METHODS: This was a prespecified substudy of 128 patients with ...
Nakagomi Akihiro - - 2012
Background: The effects of statin therapy on the production of monocyte pro-inflammatory cytokines, cardiac function and the long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear. Methods and Results: A total of 146 CHF patients with a mean left ventricular ejection fraction (LVEF) of 26.9±6.6% were divided into 2 ...
Ikeda Koji - - 2012
Background: Atherosclerosis often advances before symptoms appear. It remains uncertain whether intensive cholesterol-lowering therapy with statin is beneficial when compared with moderate cholesterol-lowering therapy in patients with subclinical carotid atherosclerosis.Methods: The PEACE study was a prospective, randomized, open-labeled, blinded end points, two-arm parallel treatment group comparison study conducted at 15 ...
Welch Meredith L - - 2012
Candidemia is an important cause of morbidity and mortality. As statins interfere with yeast membrane synthesis, we assessed whether use of statins during candidemia may cause differences in clinical outcomes. A retrospective review of 124 candidemia episodes during 2003-2008 in which all-cause and attributable mortality, length of stay and level ...
Vaduganathan Muthiah - - 2012
Recent data have suggested that statins are associated with reduced early mortality and cardiovascular events after valvular heart surgery. The midterm effects of preoperative statin therapy in the setting of valvular heart surgery are presently unclear. All patients (n = 2,120) who underwent a valvular procedure between April 2004 and ...
Argalious M Y - - 2012
BACKGROUND: /st>Acute kidney injury during endovascular aortic repair can result in a reduction in the postoperative glomerular filtration rate (GFR). The 'pleiotropic' effects of statins offer a potential mechanism of reducing the postoperative decline in the GFR. We therefore tested the hypothesis that in patients undergoing endovascular aortic repair, the ...
Nieuwkerk Pythia T - - 2012
Low levels of statin adherence may compromise treatment outcomes. The aim of this study was to investigate whether nurse-led cardiovascular risk-factor counseling could improve statin adherence and lipid levels without increasing patients' anxiety. Patients with indications for statin therapy for primary or secondary prevention of cardiovascular disease were randomly assigned ...
Nakahara Takashi T Departments of Medicine and Molecular Science, Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, - - 2012
  Statins, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are reported to be useful for the treatment of non-alcoholic steatohepatitis (NASH). Currently, there is no proven therapy for NASH. In this study, we assessed the efficacy of rosuvastatin in NASH patients with dyslipidemia.   Nineteen patients with biopsy-proven NASH with ...
Kamm Christian Philipp - - 2012
Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects. The present study evaluated the effect of atorvastatin added to interferon beta-1b in multiple sclerosis (MS) in a multicenter, randomized, parallel-group, rater-blinded study performed in eight Swiss hospitals. Seventy-seven patients with relapsing-remitting MS started interferon beta-1b every other day. ...
Kouvelos George N - - 2012
OBJECTIVE: Cardiovascular complications represent a major cause of morbidity and mortality in patients undergoing vascular surgery. This was a prospective randomized, open-label study to investigate the effect of lipid-lowering treatment by statin monotherapy or intensified by combining statin with ezetimibe on a 12-month prognosis after vascular surgery. METHODS: Patients were ...
Alford Julie C - - 2012
STUDY OBJECTIVE: To describe the prevalence of prescribing against-label statin-fibrate combination therapy. DESIGN: Retrospective cohort study. DATA SOURCE: Medstat MarketScan Commercial Claims and Encounter database. PATIENTS: Adults (aged 18-89 yrs) who were prescribed statin-fibrate combination therapy between January 1, 2003, and June 30, 2009, had pharmacy claims demonstrating two or ...
Mariscalco Giovanni - - 2012
Delirium after cardiac operations is associated with significant morbidity and death. Statins have been recently suggested to exert protective cerebral effects. This study investigated whether preoperative statins were associated with decreased incidence of postoperative delirium in patients undergoing coronary artery bypass grafting. The study enrolled 4,659 consecutive patients (21% women; ...
Ardehali Reza - - 2012
Although aortic sclerosis has been associated with an increase in adverse cardiovascular outcomes, no proven therapy has been shown to slow its progression to overt aortic stenosis (AS). Thus, the hypothesis was assessed that treatment with angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs) or statins may be associated with ...
Arimura Tadaaki - - 2012
Little is known about the efficacy and safety of intensive lowering of low-density lipoprotein cholesterol (LDL-C) with statin/ezetimibe therapy after coronary stent implantation in patients with stable angina. Fifty patients with stable angina were randomly divided into an atorvastatin (10mg/day) (A) group and an atorvastatin (10mg/day)/ezetimibe (10mg/day) (A+E) group after ...
Eindhoven Jannet A - - 2012
Aims: We aim to investigate the association between different types of statins, in particular simvastatin and atorvastatin, and long-term mortality after percutaneous coronary intervention (PCI). Methods and results: Between 2000 and 2005, a prospective cohort was constituted of 5,647 patients who underwent PCI. Type and doses of statin use were ...
Thompson Holly C - - 2012
To characterize the clinical and radiographic signs, endoscopic findings, treatment, and outcome for dogs that present with esophageal foreign bodies (EFBs), and to identify factors associated with the severity of secondary esophagitis and length of hospitalization (LOH). Retrospective case series. Private referral veterinary center. Client-owned dogs. None. Medical records for ...
Suh Hae Sun - - 2012
PURPOSE: Type 2 diabetes is associated with increased cardiovascular risk. The comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in reducing risk of cardiovascular disease in real-world settings is unknown. METHODS: A retrospective database analysis was performed using a large managed care claims database of patients identified ...
Dowlatshahi Dar - - 2012
BACKGROUND AND PURPOSE: Studies suggest a protective role for statins after intracerebral hemorrhage, but many failed to assess statin discontinuation, did not include postdischarge outcomes, or did not account for withdrawal of care. We studied the relationship between preintracerebral hemorrhage statin use and in-hospital statin discontinuation on stroke severity and ...
Nakamura Takamitsu - - 2012
BACKGROUND AND PURPOSE: It remains undetermined whether the addition of ezetimibe to ongoing statin therapy is more effective than increasing the dose of statin for reducing remnant lipoprotein levels in patients with remnant lipoproteinemia on previous statin treatment. This study examined whether combined ezetimibe and statin therapy resulted in a ...
Elis Avishay - - 2012
Statins are the treatment of choice for lowering LDL-C levels and reducing cardiovascular events. They have a remarkable safety profile, although some patients do not tolerate them. The aim of the study was to summarize the existing data on non-every day statin administration regimens. We searched the MEDLINE databases to ...
Shirakabe Akihiro - - 2012
BACKGROUND AND PURPOSE: We have reported that matrix metalloproteinase-2 (MMP-2) increased in acute heart failure (AHF) and better prognosis was found in patients with greater reduction in MMP-2. We assessed whether a statin decreased MMP-2 in AHF. METHODS AND RESULTS: The serum MMP-2 levels were measured on admission (Day 1), ...
Jose M Alvin - - 2012
The objective of the study was to evaluate the safety and efficacy of atorvastatin compared with simvastatin and pravastatin in patients of hyperlipidemia. This was a randomized, parallel group, open-label study conducted at KG hospital, Coimbatore, Tamilnadu, India. Twenty hyperlipidemia patients each taking atorvastatin 20 mg, pravastatin 20 mg and ...
Natsuaki Masahiro - - 2012
Therapeutic strategies preventing late target lesion revascularization (TLR) after drug-eluting stent implantation have not been yet adequately investigated. In 13,087 consecutive patients undergoing first percutaneous coronary intervention in the CREDO-Kyoto Registry Cohort-2, we identified 10,221 patients who were discharged alive after implantation of sirolimus-eluting stents (SESs) only (SES stratum 5,029) ...
Lim Sang Yup - - 2012
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated the effectiveness of statin therapy in reducing MACE in patients with acute myocardial infarction (AMI) and renal dysfunction (RD). In the present retrospective study of 12,853 patients with ...
Dupuis E C - - 2012
Background:  Methotrexate (MTX) is commonly used by dermatologists in treatment of psoriasis (PsO) and by rheumatologists for psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Guidelines on MTX use have been published in both specialties yet current use patterns remain unknown. Objective:  This study examined MTX use amongst Canadian dermatologists and ...
López-Farré Antonio J - - 2012
Background:  Stroke patients have a high risk of vascular recurrence. Biomarkers related to vascular recurrence, however, remain to be identified. Our aim was to identify, through proteomic analysis, plasma biomarkers associated with vascular recurrence within one year after the first ischemic stroke. Methods:  This is a substudy (n=134) of a ...
Angeli Fabio - - 2012
Background: Current guidelines for the treatment of patients with acute coronary syndrome (ACS) recommend the use of statins before hospital discharge. However, the prognostic impact of an early initiation of treatment is uncertain. Methods: We reviewed data from randomized controlled trials (RCTs) to test the hypothesis that differences in the ...
Nozue Tsuyoshi - - 2012
Systemic therapy with statin has been shown to lower the risk of coronary events; however, the in vivo effects of statin therapy on plaque volume and composition are less understood. We conducted a prospective, open-labeled, randomized, multicenter study in 11 centers in Japan. A total of 164 patients were randomized ...
Sasaki Junko - - 2012
We prospectively examined the additional effects of highly purified eicosapentaenoic acid (EPA) particularly on the vascular function of diabetic patients with hypercholesterolemia receiving statin therapy. We enrolled 28 patients with type 2 diabetes complicated by dyslipidemia who had been treated with statins for at least one year. The patients were ...
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