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Jeong Jin Hee JH From the *Department of Emergency Medicine, Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do; †Department of Emergency Medicine, Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggi-do; and ‡Department of Emergency Medicine, Seoul National University Hospital; and §Department of Emergency Medicine, Inje University College of medicine, Inje University Seoul Paik Hospital, Seoul, Republic of - - 2014
Patients with febrile seizures (FSs) are observed in emergency departments or admitted to hospitals because of the possibility of recurrence. There are no guidelines regarding the observation time for recurring FS. The aim of this study was to identify the rate, time, risk factors, and cumulative probability of early recurrence. ...
Wu Yuanxing Y - - 2014
Objective: We sought to evaluate the safety of imipenem and meropenem in the treatment of infections in neurosurgical patients. Methods: An observational retrospective study was conducted of consecutive cases treated with imipenem from Sept.2007 to Sept.2009 and meropenem within 1 year from Sept. 2008 in Beijing Tiantan Hospital,China. Data including ...
Thompson Atalie C AC School of Public Health, University of California Berkeley, Berkeley, California, U.S.A; Stanford University School of Medicine, Stanford, California, - - 2014
To determine whether adult minority patients with medically refractory temporal lobe epilepsy (TLE) experience significantly longer times to anterior temporal lobectomy (ATL) following presurgical evaluation. A retrospective cohort study of 223 adult patients with epilepsy (PWE) and unilateral mesial temporal sclerosis who completed presurgical evaluation in the epilepsy monitoring unit ...
Correia Fernando D FD Department of Neurology, Hospital Santo António-Centro Hospitalar do Porto, Largo Prof Abel Salazar, Oporto, Portugal. Electronic address: - - 2014
Eslicarbazepine acetate (ESL) is a new generation voltage-gated sodium channel blocker. It has completed one phase II clinical trial and three phase III clinical trials, two of which with 1-year open label extensions. ESL was approved in 2009 by the European Medicines Agency as adjunctive therapy in adults with partial-onset ...
Sun Zhenxing Z Department of Neurosurgery, Yuquan Hospital, Medical Center, Tsinghua University, Beijing 100049, - - 2014
Anterior temporal lobectomy (ATL) is the most common surgical treatment for temporal lobe epilepsy (TLE), although long-term prognosis is often less favorable than short-term outcomes. This study aimed to examine the outcomes of patients with TLE 5 years after undergoing ATL, and to seek possible predictors of prognosis. We examined ...
Sierra-Marcos Alba A Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV), and University of Lausanne, Lausanne, - - 2014
To evaluate an automated seizure detection (ASD) algorithm in EEGs with periodic and other challenging patterns. Selected EEGs recorded in patients over 1year old were classified into four groups: A. Periodic lateralized epileptiform discharges (PLEDs) with intermixed electrical seizures. B. PLEDs without seizures. C. Electrical seizures and no PLEDs. D. ...
Sillanpää Matti M Departments of Public Health and Child Neurology, University of Turku, Turku, - - 2014
Clinical conditions of long-term cure in childhood-onset epilepsy, defined as sustained remission off antiepileptic drug (AED) treatment, are not well known. To address that clinically important question, we determined clinical factors predictive of long-term seizure cure in a population-based cohort of 133 patients followed up since their first seizure before ...
Ulate-Campos A A Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España. Electronic address: - - 2014
Epilepsy, which is present in 0.5-1% of the paediatric population,is one of the most frequent childhood neurological disorders. Approximately 20% to 30% of these cases will be drug-resistant. The objective of this study is to describe the impact of vagal nerve stimulation (VNS) on seizures and quality of life in ...
Bowden Greg G Departments of Neurological Surgery - - 2014
Object Sylvian fissure arteriovenous malformations (AVMs) present substantial management challenges because of the critical adjacent blood vessels and functional brain. The authors investigated the outcomes, especially hemorrhage and seizure activity, after stereotactic radiosurgery (SRS) of AVMs within or adjacent to the sylvian fissure. Methods This retrospective single-institution analysis examined the ...
Zaccara Gaetano G Unit of Neurology, Department of Medicine, Florence Health Authority, Firenze, - - 2014
To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures. This was a randomized, double-blind, flexible-dose, parallel-group noninferiority study of pregabalin and levetiracetam (randomized 1:1) as adjunctive treatment in adult patients with refractory partial seizures. The study included ...
Karamchandani Rahul Ramesh RR Department of Neurology, The University of Texas Health Science Center at Houston Medical School, Houston, TX, - - 2014
Current guidelines recommend against the use of phenytoin following aneurysmal subarachnoid hemorrhage (aSAH) but consider other anticonvulsants, such as levetiracetam, acceptable. Our objective was to evaluate the risk of poor functional outcomes, delayed cerebral ischemia (DCI) and delayed seizures in aSAH patients treated with levetiracetam versus phenytoin. Medical records of ...
Yamada Keitaro K Department of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan. Electronic address: - - 2014
To evaluate the prognostic importance of electroencephalography (EEG) findings at cessation of epileptic spasms for seizure outcome. We reviewed 71 children with West syndrome (cryptogenic 14) who had obtained control of epileptic spasms with initial treatment (adrenocorticotropic hormone (ACTH) 37, high-dose vitamin B6 2, and antiepileptic drugs 32). According to ...
Bilginer Burcak B Department of Neurosurgery, Hacettepe University School of Medicine, Sıhhıye, 06100, Ankara, Turkey, - - 2014
Cavernous malformations (CMs) of the central nervous system (CNS) are angiographically occult vascular lesions that affect approximately 0.5 % of the general population, and one quarter of all CMs occurs in children. We retrospectively analyzed demographic, clinical, radiological, management, and follow-up data of 36 pediatric patients with CMs from a single ...
Haapaniemi Elena E Department of Neurology (E.H., D.S., J.P., T. Sipi, S.M., T. Sairanen, S.C., R.R., M.K., T.T., A.M.) and Department of Neurosurgery (J.S.), Helsinki University Central Hospital, Helsinki, Finland; Neurology Department, EA 1046, Université Lille Nord de France, CHU Lille, Lille, France (C.R., C.C.); and Departments of Medicine and the Florey, University of Melbourne, Melbourne, Australia - - 2014
Seizures are a common complication of intracerebral hemorrhage (ICH). We developed a novel tool to quantify this risk in individual patients. Retrospective analysis of the observational Helsinki ICH Study (n=993; median follow-up, 2.7 years) and the Lille Prognosis of InTra-Cerebral Hemorrhage (n=325; 2.2 years) cohorts of consecutive ICH patients admitted ...
Krauss Gregory L GL Johns Hopkins University, Baltimore, Maryland, - - 2014
To evaluate safety, tolerability, seizure frequency, and regional variations in treatment responses with the AMPA antagonist, perampanel, in a large extension study during up to 3 years of treatment. Patients ≥12 years old with partial-onset seizures despite treatment with 1-3 antiepileptic drugs at baseline completed a perampanel phase III trial and entered ...
Satishchandra P P Department of Neurology, National Institute of Mental Health and NeuroSciences [NIMHANS], Bangalore, India. Electronic address: - - 2014
To evaluate the role of intermittent prophylaxis with clobazam in the management of HWE in a long-term prospective study. Two hundred and sixty patients [M:F - 194:66] with HWE were recruited. Patients were divided into: (a) 'HWE alone' (n=198) - received intermittent clobazam prophylaxis, 1-1½h prior to hot water head ...
Heyman Eli E Department of Pediatric Neurology, Assaf Harofeh Medical Center, Zerifin, Israel; Sackler School of Medicine, Tel Aviv University, - - 2014
Despite the introduction of multiple new antiepileptic drugs in the past two decades, many patients with epilepsy continue to experience uncontrolled seizures or significant side effects. To present our experience with felbamate therapy in children with drug-resistant epilepsy. We retrospectively reviewed the medical charts and video-EEG recordings of all patients ...
Pugin Deborah - - 2014
Seizures refractory to third-line therapy are also labeled super-refractory status epilepticus (SRSE). These seizures are extremely difficult to control and associated with poor outcome. We aimed to characterize efficacy and side-effects of continuous infusions of pentobarbital (cIV-PTB) treating SRSE. We retrospectively reviewed continuous electroencephalography (cEEG) reports for all adults with ...
Kanemura Hideaki H Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Japan. Electronic address: - - 2014
The prognosis of rolandic epilepsy (RE) is considered favorable. Since a moderate proportion of cases presents with isolated seizures, continuous treatment should be considered only for frequent seizures. Clinical and electroencephalogram (EEG) markers to predict seizure recurrence need to be identified. The purpose of this study was to identify EEG ...
Arcos A A Neurosurgical Department, Carlos Haya Hospital, Málaga, - - 2014
Despite the introduction of new antiepileptic drugs and advances in the surgical treatment of epilepsy, an important group of patients still remains uncontrolled by any of these methods. The relatively recent introduction of vagus nerve stimulation is yet another possible treatment for refractory epilepsy. This safe, simple, and adjustable technique ...
Kim Jiha J Department of Neurosurgery, Kangwon National University Hospital, Chuncheon, Gangwon-Do, South - - 2014
Seizure is the most common presentation in patients with cerebral cavernous malformations (CCMs). Although many articles have documented seizure outcomes after resection of CCM, few have conducted long-term follow-ups; thus, the fluctuating seizure outcomes have been neglected. The purpose of this study is to describe long-term postoperative seizure outcomes in ...
von Podewils Felix F Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-University, Department of Neurology, Epilepsy Center, Sauerbruchstrasse, 17489 Greifswald, Germany. Electronic address: - - 2014
The spontaneous course of idiopathic generalized epilepsy (IGE) is still controversial. The aim of this study was both to investigate the long-term spontaneous course and to identify factors that are predictive for epilepsy remission in a small cohort of 15 IGE patients (9 women) who refused antiepileptic drug (AED) treatment ...
Nowomiejska Katarzyna - - 2014
The aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patientswith pretreatment baseline examination during 2-years of the follow-up. 29 epilepsy patients were included into the study, but 15 individuals were excluded due to ...
Thorbecke Rupprecht R Epilepsy Center Bethel, Clinic Mara, Bielefeld, - - 2014
To evaluate the effects of a postsurgical rehabilitation program on employment status 2 years after temporal lobe epilepsy surgery in relation to other predictors. Employment outcome 2 years after temporal lobe resection in a group of 232 adult patients with the offer of a 3-week inpatient rehabilitation program immediately after surgery ("Reha ...
Gobbi Giuseppe G Child Neurology Unit, IRCCS (Istituto delle Scienze Neurologiche di Bologna), Bellaria Hospital, - - 2014
Frontal lobe epilepsy is a common focal epilepsy in children and is often difficult to treat. Adrenocorticotropic hormone (ACTH) or steroids have been used for patients with several forms of medically intractable epilepsy. We evaluated the short, medium, and long-term evolution of patients with frontal lobe epilepsy and secondary bilateral ...
Semah Franck F Neuroimaging Department, University Hospital Roger Salengro, - - 2014
Aim. The aim of this study was to evaluate the impact of two different therapeutic strategies in patients with partial seizures who were intractable to the first prescribed antiepileptic drug (AED); alternative monotherapy vs early add-on treatment. Methods. We conducted an open, cluster-randomised, prospective, controlled trial in patients with persistent ...
Lee Kyung Yeon KY Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of - - 2014
Some full-term neonates presenting seizures show diffusion-restricted lesions in the cerebral white matter on brain diffusion-weighted imaging (DWI). The purpose of this study was to describe the clinical characteristics and DWI findings in a group of neonates with seizures, white matter lesions on DWI, and a high incidence of rotavirus ...
Granata Tiziana T Department of Pediatric Neuroscience, Carlo Besta Neurological Institute, Milan, Italy. Electronic address: - - 2014
Surgical disconnection of the affected hemisphere is considered the treatment of choice for Rasmussen encephalitis (RE), however few data on long-term outcomes after disconnective surgery are available. We report on long-term seizure, cognitive and motor outcomes after disconnective surgery in 16 (8 M, 8 F) RE patients. Pre- and post-operative ...
von der Brelie Christian C Departments of Neurosurgery - - 2014
Object Sufficient data on surgical treatment and seizure outcome of pediatric patients with different types of epilepsy, especially drug-resistant epilepsy and associated cerebral cavernous malformations, are scarce. The aim of this study was to carefully evaluate seizure outcome using the International League Against Epilepsy (ILAE) classification with regard to the ...
Lee Yun-Jeong YJ Division of Pediatric Neurology, Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, - - 2014
Hemispherectomy reportedly produces remarkable results in terms of seizure outcome and quality of life for medically intractable hemispheric epilepsy in children. We reviewed the neuroradiologic findings, pathologic findings, epilepsy characteristics, and clinical long-term outcomes in pediatric patients following a hemispheric disconnection. We retrospectively studied 12 children (8 males) who underwent ...
Taub Katherine S KS Division of Neurology, Departments of Pediatrics and Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, - - 2014
Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustained ...
Arntz Renate M - - 2014
The proportion of strokes occurring in younger adults has been rising over the past decade. Due to the far longer life expectancy in the young, stroke in this group has an even larger socio-economic impact. However, information on etiology and prognosis remains scarce.Methods/design: ODYSSEY is a multicentre prospective cohort study ...
Madžar Dominik D Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, - - 2014
Seizures are a common complication after intracerebral hemorrhage (ICH) but there is a substantial lack of information on the long-term incidence in ICH survivors and whether post-ICH seizures affect functional long-term outcome. Over a five-year period 464 consecutive patients with spontaneous ICH were analyzed. Focussing on 1-year ICH survivors, clinical, ...
Rohn Benjamin B Department of Neurosurgery, Heinrich-Heine-Universität, Düsseldorf, - - 2014
Background In ruptured and unruptured arteriovenous malformations (AVMs), bleeding and re-bleeding rate and efficacy of microsurgical, endovascular, and radiosurgical treatment to prevent hemorrhage are well known. Uncertainty exists concerning the benefit of therapy with regard to headache, epilepsy, and quality of life (QoL) in unruptured AVMs. The objective of the present ...
Sànchez Javier J Brain Research Centre, Institute of Neurosciences, Guayaquil Welfare Board, Guayaquil, Ecuador. Electronic address: - - 2014
There is a lack of information from South America regarding factors that predict the clinical outcomes of patients treated medically for mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). This study was conducted to determine which of these factors are the most important. This study included 110 South American patients ...
Willie Jon T JT 1Department of Neurosurgery, 2Department of Neurology, 3Interventional MRI Program, Emory University Hospital, Atlanta, GA 4Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 5Department of Neurology, University of Washington School of Medicine, Seattle, WA 6Visualase, Inc., Houston, TX 7Department of Pathology, 8Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, - - 2014
Open surgery effectively treats mesial temporal lobe epilepsy (MTLE), but carries risks of neurocognitive deficits, which may be reduced with minimally invasive alternatives. To describe technical and clinical outcomes of stereotactic laser amygdalohippocampotomy (SLAH) with real-time magnetic resonance thermal imaging (MRTI) guidance. Under general anesthesia and utilizing standard stereotactic methods, ...
Conry Joan A JA Children's National Medical Center, Washington, District of Columbia, - - 2014
To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS). Eligible patients from two randomized controlled trials (Phase II OV-1002 and Phase III OV-1012) were able to enroll in open-label extension (OLE) study OV-1004 beginning in December 2005 and received clobazam until they discontinued (mandatory ...
Mehta Sahil S Department of Neurology, Post Graduate Institute of Medical Science and Research, Chandigarh, - - 2014
Purpose: Although seizures are the most common presentation of neurocysticercosis (NCC), the electroclinical characteristics of the seizures have not been adequately studied. Materials and Methods: The study cohort included 308 consecutive patients presenting with a new-onset seizure, both acute symptomatic or unprovoked. They were divided into two groups: Group 1 ...
Sugano Hidenori H Department of Neurosurgery, Juntendo University, Tokyo, - - 2014
Some patients with Sturge-Weber syndrome (SWS) need epilepsy surgery for adequate seizure control and prevention of psychomotor deterioration. The majority of patients with SWS have leptomeningeal angioma located over the temporal, parietal, and occipital lobes. We applied posterior quadrant disconnection surgery for this type of SWS with intractable seizure. We ...
Braun Kees P J KP aDepartment of Child Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands bEpilepsy Research Group, Berlin, - - 2014
Based on the available evidence, we aim to balance risks and benefits of antiepileptic drug (AED) withdrawal in medically and surgically treated adults and children who achieved remission. We summarize risks and predictors of seizure relapse after AED withdrawal and chances of not regaining seizure freedom. Finally, we discuss how ...
Ansari Shaheryar F SF Department of Neurological Surgery, Goodman Campbell Brain and Spine, Indiana University, 355 W 16th St. Ste 5100, Indianapolis, IN, 46202, USA, - - 2014
The effectiveness of seizure prophylaxis in controlling postoperative seizures following craniotomy for tumor resection is unclear. Most patients are seizure-free before surgery. To prevent seizures, it is common to treat tumor craniotomy patients postoperatively with an antiepileptic drug (AED). The authors retrospectively analyzed seizure occurrence with and without postoperative prophylactic ...
Ladino Lady D LD Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada; Neurology Section, Hospital Pablo Tobón Uribe, Medellín, Colombia. Electronic address: - - 2014
No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. We searched MEDLINE and Embase using Medical Subject Headings ...
Cardamone Michael M Department of Neurology, Sydney Children's Hospital, Randwick, New South Wales, Australia; The School of Women's and Children's Health, Medicine UNSW, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: - - 2014
To evaluate the efficacy and side effects of oral mammalian target of rapamycin (mTOR) inhibitors in children and adolescents with tuberous sclerosis complex (TSC) and intractable epilepsy or subependymal giant cell astrocytoma (SEGA). Single-center series of 13 children and adolescents with TSC who received sirolimus or everolimus (mTOR inhibitors). The ...
Seinfeld Syndi S Neurology, Virginia Commonwealth University, Richmond, Virginia, - - 2014
Treatment of seizures varies by region, with no standard emergency treatment protocol. Febrile status epilepticus (FSE) is often a child's first seizure; therefore, families are rarely educated about emergency treatment. From 2002 to 2010, 199 subjects, age 1 month to 6 years, were recruited as part of a prospective, multicenter study of ...
Rizvi Syed A A SA Division of Neurology, Department of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, BOX 26, Room 1622, Saskatoon, SK S7N OW8, Canada. Electronic address: - - 2014
Video electroencephalographic monitoring (VEM) is used to record ictal and interictal epileptiform activity and to ascertain the level of concordance between the two. Often, taper or discontinuation of anti-epileptic (AED) therapy is needed to facilitate seizure occurrence. The safety of this practice is unclear and long-term sequelae have yet to ...
Sharma V - - 2014
Because of a lack of contemporary data regarding seizures after cardiac surgery, we undertook a retrospective analysis of prospectively collected data from 11 529 patients in whom cardiopulmonary bypass was used from January 2004 to December 2010. A convulsive seizure was defined as a transient episode of disturbed brain function ...
Cusmai Raffaella R Division of Neurology, "Bambino Gesù" Children's Hospital, IRCCS, Rome, - - 2014
To evaluate the efficacy and tolerability of add-on rufinamide in children with refractory epilepsy symptomatic of neuronal migration disorders. We recruited 69 patients in a prospective, open-label, add-on treatment study from six Italian and one German centers for pediatric and adolescent epilepsy care according to the following criteria: age 3 ...
Dewan Michael C MC Department of Neurological Surgery, Vanderbilt University, Nashville, Tennessee, - - 2014
The objective of this study was to determine current practices regarding seizure prophylaxis in aneurysmal subarachnoid hemorrhage (aSAH). An eight question survey was sent to 25 US centers with high volume aSAH cases (>100 annually). Respondents were asked about institutional practices regarding use, duration, and type of seizure prophylaxis. 13 ...
Jin Yichao Y Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, - - 2014
The objective of this study was to retrospectively review the postoperative seizure outcome in patients with short duration of epilepsy associated with cavernous malformations and analyze the effect of surgical methods on seizure outcome in such population. 36 patients with short duration of epilepsy (shorter than 12 months) associated with ...
Syvertsen Marte R MR Department of Neurology, Drammen Hospital, Drammen, Norway; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, - - 2014
The view that juvenile myoclonic epilepsy (JME) is a uniform and life-long disorder is currently being challenged. The aim of this study was to assess the seizure and psychosocial outcome of JME at least 20 years after onset. In 1992, 42 patients with JME were identified. In 2012, 37 agreed ...
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