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von der Brelie Christian C Departments of Neurosurgery - - 2014
Object Sufficient data on surgical treatment and seizure outcome of pediatric patients with different types of epilepsy, especially drug-resistant epilepsy and associated cerebral cavernous malformations, are scarce. The aim of this study was to carefully evaluate seizure outcome using the International League Against Epilepsy (ILAE) classification with regard to the ...
Taub Katherine S KS Division of Neurology, Departments of Pediatrics and Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, - - 2014
Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustained ...
Arntz Renate M - - 2014
The proportion of strokes occurring in younger adults has been rising over the past decade. Due to the far longer life expectancy in the young, stroke in this group has an even larger socio-economic impact. However, information on etiology and prognosis remains scarce.Methods/design: ODYSSEY is a multicentre prospective cohort study ...
Madžar Dominik D Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, - - 2014
Seizures are a common complication after intracerebral hemorrhage (ICH) but there is a substantial lack of information on the long-term incidence in ICH survivors and whether post-ICH seizures affect functional long-term outcome. Over a five-year period 464 consecutive patients with spontaneous ICH were analyzed. Focussing on 1-year ICH survivors, clinical, ...
Rohn Benjamin B Department of Neurosurgery, Heinrich-Heine-Universität, Düsseldorf, - - 2014
Background In ruptured and unruptured arteriovenous malformations (AVMs), bleeding and re-bleeding rate and efficacy of microsurgical, endovascular, and radiosurgical treatment to prevent hemorrhage are well known. Uncertainty exists concerning the benefit of therapy with regard to headache, epilepsy, and quality of life (QoL) in unruptured AVMs. The objective of the present ...
Sànchez Javier J Brain Research Centre, Institute of Neurosciences, Guayaquil Welfare Board, Guayaquil, Ecuador. Electronic address: - - 2014
There is a lack of information from South America regarding factors that predict the clinical outcomes of patients treated medically for mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). This study was conducted to determine which of these factors are the most important. This study included 110 South American patients ...
Willie Jon T JT 1Department of Neurosurgery, 2Department of Neurology, 3Interventional MRI Program, Emory University Hospital, Atlanta, GA 4Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 5Department of Neurology, University of Washington School of Medicine, Seattle, WA 6Visualase, Inc., Houston, TX 7Department of Pathology, 8Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, - - 2014
Open surgery effectively treats mesial temporal lobe epilepsy (MTLE), but carries risks of neurocognitive deficits, which may be reduced with minimally invasive alternatives. To describe technical and clinical outcomes of stereotactic laser amygdalohippocampotomy (SLAH) with real-time magnetic resonance thermal imaging (MRTI) guidance. Under general anesthesia and utilizing standard stereotactic methods, ...
Conry Joan A JA Children's National Medical Center, Washington, District of Columbia, - - 2014
To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS). Eligible patients from two randomized controlled trials (Phase II OV-1002 and Phase III OV-1012) were able to enroll in open-label extension (OLE) study OV-1004 beginning in December 2005 and received clobazam until they discontinued (mandatory ...
Sugano Hidenori H Department of Neurosurgery, Juntendo University, Tokyo, - - 2014
Some patients with Sturge-Weber syndrome (SWS) need epilepsy surgery for adequate seizure control and prevention of psychomotor deterioration. The majority of patients with SWS have leptomeningeal angioma located over the temporal, parietal, and occipital lobes. We applied posterior quadrant disconnection surgery for this type of SWS with intractable seizure. We ...
Braun Kees P J KP aDepartment of Child Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands bEpilepsy Research Group, Berlin, - - 2014
Based on the available evidence, we aim to balance risks and benefits of antiepileptic drug (AED) withdrawal in medically and surgically treated adults and children who achieved remission. We summarize risks and predictors of seizure relapse after AED withdrawal and chances of not regaining seizure freedom. Finally, we discuss how ...
Ansari Shaheryar F SF Department of Neurological Surgery, Goodman Campbell Brain and Spine, Indiana University, 355 W 16th St. Ste 5100, Indianapolis, IN, 46202, USA, - - 2014
The effectiveness of seizure prophylaxis in controlling postoperative seizures following craniotomy for tumor resection is unclear. Most patients are seizure-free before surgery. To prevent seizures, it is common to treat tumor craniotomy patients postoperatively with an antiepileptic drug (AED). The authors retrospectively analyzed seizure occurrence with and without postoperative prophylactic ...
Ladino Lady D LD Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada; Neurology Section, Hospital Pablo Tobón Uribe, Medellín, Colombia. Electronic address: - - 2014
No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. We searched MEDLINE and Embase using Medical Subject Headings ...
Cardamone Michael M Department of Neurology, Sydney Children's Hospital, Randwick, New South Wales, Australia; The School of Women's and Children's Health, Medicine UNSW, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: - - 2014
To evaluate the efficacy and side effects of oral mammalian target of rapamycin (mTOR) inhibitors in children and adolescents with tuberous sclerosis complex (TSC) and intractable epilepsy or subependymal giant cell astrocytoma (SEGA). Single-center series of 13 children and adolescents with TSC who received sirolimus or everolimus (mTOR inhibitors). The ...
Seinfeld Syndi S Neurology, Virginia Commonwealth University, Richmond, Virginia, - - 2014
Treatment of seizures varies by region, with no standard emergency treatment protocol. Febrile status epilepticus (FSE) is often a child's first seizure; therefore, families are rarely educated about emergency treatment. From 2002 to 2010, 199 subjects, age 1 month to 6 years, were recruited as part of a prospective, multicenter study of ...
Rizvi Syed A A SA Division of Neurology, Department of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, BOX 26, Room 1622, Saskatoon, SK S7N OW8, Canada. Electronic address: - - 2014
Video electroencephalographic monitoring (VEM) is used to record ictal and interictal epileptiform activity and to ascertain the level of concordance between the two. Often, taper or discontinuation of anti-epileptic (AED) therapy is needed to facilitate seizure occurrence. The safety of this practice is unclear and long-term sequelae have yet to ...
Sharma V - - 2014
Because of a lack of contemporary data regarding seizures after cardiac surgery, we undertook a retrospective analysis of prospectively collected data from 11 529 patients in whom cardiopulmonary bypass was used from January 2004 to December 2010. A convulsive seizure was defined as a transient episode of disturbed brain function ...
Cusmai Raffaella R Division of Neurology, "Bambino Gesù" Children's Hospital, IRCCS, Rome, - - 2014
To evaluate the efficacy and tolerability of add-on rufinamide in children with refractory epilepsy symptomatic of neuronal migration disorders. We recruited 69 patients in a prospective, open-label, add-on treatment study from six Italian and one German centers for pediatric and adolescent epilepsy care according to the following criteria: age 3 ...
Dewan Michael C MC Department of Neurological Surgery, Vanderbilt University, Nashville, Tennessee, - - 2014
The objective of this study was to determine current practices regarding seizure prophylaxis in aneurysmal subarachnoid hemorrhage (aSAH). An eight question survey was sent to 25 US centers with high volume aSAH cases (>100 annually). Respondents were asked about institutional practices regarding use, duration, and type of seizure prophylaxis. 13 ...
Jin Yichao Y Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, - - 2014
The objective of this study was to retrospectively review the postoperative seizure outcome in patients with short duration of epilepsy associated with cavernous malformations and analyze the effect of surgical methods on seizure outcome in such population. 36 patients with short duration of epilepsy (shorter than 12 months) associated with ...
Syvertsen Marte R MR Department of Neurology, Drammen Hospital, Drammen, Norway; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, - - 2014
The view that juvenile myoclonic epilepsy (JME) is a uniform and life-long disorder is currently being challenged. The aim of this study was to assess the seizure and psychosocial outcome of JME at least 20 years after onset. In 1992, 42 patients with JME were identified. In 2012, 37 agreed ...
Gloss David D Neurology MC14-05, 100 N Academy Ave, Geisinger Medical Center, Danville, USA, PA - - 2014
Epilepsy is a serious brain disorder characterized by recurrent unprovoked seizures. Approximately two-thirds of seizures can be controlled with antiepileptic medications (Kwan 2000). For some of the others, surgery can completely eliminate or significantly reduce the occurrence of disabling seizures. Localization of epileptogenic areas for resective surgery is far from ...
Al-Otaibi Faisal F Division of Neurosurgery, Neuroscience Department, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi - - 2014
Introduction. The common surgical approach for standard temporal lobectomy is a question-mark skin incision and a frontotemporal craniotomy. Herein, we describe minicraniotomy approach through a linear skin incision for standard temporal lobectomy. Methods. A retrospective observational cohort study was conducted for a group of consecutive 21 adult patients (group I) ...
Hodges Joseph C JC Baylor College of Medicine and Texas Children's Hospital, 6701 Fannin Street No. 1250, Houston, TX 77030, USA ; University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, - - 2014
Background. Antiepileptic drugs (AEDs) noncompliance is associated with increased risk of seizures and morbidity in seizure disorder patients. Objective. To identify risk factors that correlated to higher levels of morbidity, measured by emergency room (ER) utilization by seizure disorder members taking AED. Methods. Patients with primary or secondary diagnosis of ...
Steiger Hans-Jakob HJ Department of Neurosurgery, Heinrich-Heine-Universität, Moorenstr. 5, Geb. 13.71, Düsseldorf, D-40225, Germany, - - 2014
The therapeutic benefits of microsurgery for cerebral arteriovenous malformations (AVM) with regard to headache and epilepsy are not well known. The objective of the present review is to discuss the available evidence and our own experience, which showed that two-thirds of the patients with preoperative epilepsy experienced long-term improvement, one-sixth ...
Stigsdotter-Broman Lina L Epilepsy Research Group, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, - - 2013
Analyze the long-term outcome of callosotomies with regard to seizure types and frequencies and antiepileptic drug treatment. This longitudinal observational study is based on data from the prospective Swedish National Epilepsy Surgery Register. Thirty-one patients had undergone callosotomy in Sweden 1995-2007 and had been followed for 2 and 5 or ...
Chen David K DK Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.; Neurology Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, - - 2014
To evaluate therapeutic efficacy upon augmenting the initial communication to patients regarding the diagnosis of psychogenic nonepileptic seizures (PNES) with a novel, brief group psychoeducation administered by the same team that provided the video-electroencephalography (VEEG) confirmed diagnosis and within 4 weeks of the diagnosis. Prior to discharge from the epilepsy monitoring ...
Dragoumi Pinelopi - - 2013
Idiopathic epilepsies and epileptic syndromes predominate childhood and adolescence epilepsy. The aim of the present study was to investigate the clinical course and outcome of idiopathic childhood epilepsy and identify variables determining both early and long-term prognosis. We followed 303 children with newly diagnosed idiopathic epilepsy aged 1--14 years old, ...
Helmstaedter C - - 2013
In the epilepsy community, there is talk that the number of classical patients with early onset temporal lobe epilepsy (TLE) and Ammon's horn sclerosis (AHS) is decreasing. This is counterintuitive, considering the success story of epilepsy surgery, improved diagnostic methods and the current recommendation of early admission to surgery. In ...
Baranoski Jacob F - - 2013
Seizures are a common presenting sign of intracranial arteriovenous malformations (AVMs). The object of this meta-analysis was to determine if the modality selected to treat AVMs affects the rate of seizure outcomes. All published data describing seizure status as an outcome goal over the past 20 years were included in ...
Arya Ravindra - - 2013
This study explored predictors of response to vagus nerve stimulation in childhood-onset epilepsy. This retrospective chart review included all patients with new vagus nerve stimulator insertion between January 1, 2006, and December 31, 2011. Primary outcome was change in seizure frequency classified on the International League Against Epilepsy scale. Overall, ...
Ius Tamara - - 2013
Object Although a number of recent studies on the surgical treatment of insular low-grade glioma (LGG) have demonstrated that aggressive resection leads to increased overall patient survival and decreased malignant progression, less attention has been given to the results with respect to tumor-related epilepsy. The aim of this investigation was ...
An Dongmei - - 2013
Simultaneous electroencephalography/functional magnetic resonance imaging (EEG/fMRI) recording can noninvasively map in the whole brain the hemodynamic response following an interictal epileptic discharge. EEG/fMRI is gaining interest as a presurgical evaluation tool. This study aims to determine how hemodynamic responses related to epileptic activity can help predict surgical outcome in patients ...
Terra Vera C - - 2013
Vagus nerve stimulation (VNS) seems to be effective in the management of selected cases of pharmacoresistant epilepsy in children. This was a case-control prospective study of children with refractory epilepsy submitted to vagal nerve stimulator implantation and a control group with epilepsy treated with antiepileptic drugs. Patients under 18years of ...
Goellner Eduardo - - 2013
Seizure recurrence after epilepsy surgery has been classified as either early or late depending on the recurrence time after operation. However, time of recurrence is variable and has been arbitrarily defined in the literature. We established a mathematical model for discriminating patients with early or late seizure recurrence, and examined ...
Belcastro Vincenzo - - 2013
Early-onset absence epilepsy refers to patients with absence seizures beginning before age 4 and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a boy with absence seizures with onset at age 11 months, whose seizures increased in ...
Kunieda Takeharu - - 2013
Surgical intervention is expected to improve the quality of life in patients with intractable epilepsy by providing adequate seizure control. Although many previous studies showed various rates of seizure freedom, definite conclusions have not yet been made regarding outcomes. In order to clarify the long-term postoperative outcome for a period ...
Yu Camilla - - 2013
To evaluate the efficacy of vagus nerve stimulation (VNS) in pediatric patients with medically refractory epilepsy. We reviewed the medical records of 252 consecutive patients who underwent VNS implantation at a single center over a 5-year period. Patients with complete 6- and 12-month follow-up data were included. Analysis was also ...
Kuang Yongqin - - 2013
Background. Temporal lobe epilepsy (TLE) is a recurrent chronic nervous system disease. The conventional treatment is medicine. So far, anterior temporal lobectomy (ATL) and selective amygdalohippocampectomy (SAH) are becoming the two main approaches. Methods.To compare the therapeutic effects between SAH and ATL in the treatment of temporal lobe epilepsy, we ...
Behbahani Soroor - - 2013
The purpose of the present study was to analyze the effects of epilepsy on the autonomic control of the heart in pre-ictal phase in order to find an algorithm of early detection of seizure onset. Overall 133 epileptic seizures were analyzed from 12 patients with epilepsy (seven males and five ...
Kwan Patrick - - 2013
To evaluate the safety and tolerability of adjunctive brivaracetam (BRV), a high-affinity synaptic vesicle protein 2A (SV2A) ligand, in adults with uncontrolled epilepsy. Efficacy was also assessed in patients with focal seizures as a secondary objective, and explored by descriptive analysis in patients with generalized seizures. This was a phase ...
Dorfer Christian - - 2013
The current concept for hemispherotomy includes various lateral techniques and the vertical perithalamic hemispherotomy introduced by Delalande in 1992. We have chosen the vertical approach because of advantages that possibly influence outcome: the possibility to completely disconnect the hemisphere at the level of the thalamus obviating both the need to ...
Beghi Ettore - - 2013
The Italian League Against Epilepsy has issued evidence-based guidelines to help practicing physicians in their decision to stop or withhold antiepileptic drugs (AEDs) in patients achieving a prolonged period of seizure freedom. Six adult and two child neurologists, divided into four pairs, critically appraised 128 published reports and provided graded ...
Caballero G Christina GC PGY1 Pharmacy - - 2013
Phenytoin is standard of care for seizure prophylaxis following traumatic brain injury (TBI). Levetiracetam, an alternative antiepileptic drug, is utilized for seizure prophylaxis despite limited data supporting its use. Our primary outcome was post-TBI seizure activity measured by electroencephalogram (EEG) for levetiracetam versus phenytoin. Secondary outcomes were length of intensive ...
Gokhale Sankalp S Department of Neurology, Division of Neurocritical Care, Duke University Medical Center, Durham, North Carolina 27710, - - 2013
The risk of developing immediate postoperative seizures in patients undergoing supratentorial brain tumor surgery without anti-epileptic drug (AED) prophylaxis is 15-20%. Patients who present with pre-operative seizures and patients with supratentorial meningioma or supratentorial low grade gliomas are at significantly higher risk. There is little data on the efficacy of ...
Rathore Chaturbhuj - - 2013
To study the usefulness of the Wada test for predicting seizure outcome following anterior temporal lobectomy (ATL). From 1996 to 2002, all patients with left mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) and selected patients with right MTLE-HS underwent the Wada test before ATL at our center. Patients were ...
Shorvon Simon D - - 2013
Longitudinal cohort studies of prognosis in epilepsy have been carried out since the late 1970s and these have transformed our understanding of prognosis in epilepsy. This paper reviews the contribution of such studies and focuses particularly on the National General Practice Study of Epilepsy, a prospective population-based cohort study of ...
Dhiman Vikas - - 2013
To analyze the seizure outcome of lesionectomy for refractory epilepsy secondary to non-mesial temporal sclerosis (non-MTS) lesions. Sixty-eight patients with non-MTS lesions (M:F=42:26; age at onset: 11.7±9.6 years; age at surgery: 21.1±9.4 years), who underwent lesionectomy for refractory epilepsy were analyzed. The age at onset, frequency/type of seizure, MRI findings, ...
Berthet Jean-Philippe - - 2013
The purpose of this study was to evaluate surgical outcomes of extended sleeve lobectomy (ESL) in centrally located non-small-cell lung cancer (NSCLC), sparing lung tissue and aggressively avoiding pneumonectomy. Patients who underwent ESL between January 2006 and January 2013 were included prospectively. An atypical bronchial anastomosis was used for sleeve lobectomy involving additional ...
Bower Regina S - - 2013
Medically intractable epilepsy involving drop attacks can be difficult to manage and negatively impact quality of life. Most studies investigating the effect of corpus callosotomy (CC) on seizures have been limited, focusing on the pediatric population, or drop seizures alone, with little attention to other factors influencing seizure outcome. To ...
Ryvlin Philippe - - 2013
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in people with chronic refractory epilepsy. Very rarely, SUDEP occurs in epilepsy monitoring units, providing highly informative data for its still elusive pathophysiology. The MORTEMUS study expanded these data through comprehensive evaluation of cardiorespiratory arrests encountered in epilepsy ...
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