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Mg Rajanandh R Department of Pharmacy Practice, SRM College of - - 2014
Many patients with persistent asthma could not achieve the treatment goal for asthma with a single controller medication. The study aimed to assess the lung function and rescue medication usage in asthmatic patients receiving four different categories of drugs in combination with an inhaled corticosteroid. Recruited patients were randomized into ...
Kagohashi Katsunori K Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, - - 2014
The long-term safety of budesonide/formoterol (BUD/FM) inhalation has not been fully evaluated, particularly in elderly patients with bronchial asthma. To evaluate the 12-month safety of BUD/FM inhalation for elderly asthmatic patients, the changes in serum potassium levels and pulse rate were examined. A retrospective chart review was conducted of consecutive ...
Long Aidan A Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, and Harvard Medical School, Cambridge. Electronic address: - - 2014
The Epidemiologic Study of Xolair (omalizumab): Evaluating Clinical Effectiveness and Long-term Safety in Patients with Moderate-to-Severe Asthma (EXCELS) assessed the long-term safety of omalizumab in a clinical practice setting as part of a phase IV US Food and Drug Administration postmarketing commitment. We sought to evaluate long-term safety in omalizumab-treated ...
Santos N N Centro Hospitalar São João, E.P.E., Serviço de Imunoalergologia, Porto, Portugal. Electronic address: - - 2014
Systemic reactions (SR) to subcutaneous immunotherapy (SCIT) are rare but potentially severe. The use of different definitions and classifications hampered comparability between studies. To determine the frequency of SR to SCIT with airborne allergens, and to characterise and classify them according to the WAO 2010 recommendations. Cross-sectional, retrospective study. Data ...
Rajanandh Muhasaparur G MG Department of Pharmacy Practice, SRM College of Pharmacy, Tamil Nadu, - - 2014
There is no comparative study among asthma patients receiving first-line versus various second-line treatment regimens for mild to moderate persistent asthma. We assessed the pulmonary function in asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide in a pilot group. Patients were recruited as per the study criteria and randomly ...
Acquaviva Michael A MA Riley Hospital for Children at IU Health. 1Contribution: This author helped design the study, conduct the study, analyze the data, and write the - - 2014
This study examined the safety and efficacy of a laryngeal mask airway (LMA), compared to an endotracheal tube (ETT) for children undergoing elective esophagogastroduodenoscopy (EGD). Eighty-four ASA I-III patients were randomly assigned to receive an ETT or LMA. All participants were premedicated with midazolam 0.5 mg/kg (up to 15 mg). ...
Molimard M M INSERM, Unité 657, IFR 99, Université de Bordeaux, Département de Pharmacologie, CHU de Bordeaux, 33076 Bordeaux Cedex, France. Electronic address: - - 2014
Severe persistent asthma represents a major and costly public health issue. There is evidence that long-term treatment with omalizumab might have disease-modifying activity but data on the consequences of discontinuing treatment after a positive response are limited. The purpose of this study was to investigate-in real-life prescribing conditions-what happens when ...
Steurer-Stey Claudia C 1 Department of General Practice and Health Services Research, University of Zurich, Zurich, - - 2014
Background: Adherence to self-management in asthma is poor. Aim: To investigate the effect of disease-unspecific motivational training on self-management adherence in addition to asthma-specific patient education. Methods: We randomized patients with partly controlled asthma to asthma education, with or without the Zurich Resource Model (ZRM) training. Main elements of the ...
Adaba Franklin F Department of Upper Gastrointestinal Surgery, Worcestershire Acute Hospitals NHS Trust, Charles Hastings Way, Worcester WR5 1DD, UK. Electronic address: - - 2014
Patients with refractory respiratory symptoms related to gastro-oesophageal reflux disease (GORD) such as asthma and cough are being referred for laparoscopic fundoplication (LFP), as recommended by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). However there are limited data regarding symptomatic response to fundoplication in this group of patients. ...
Yalcin Arzu Didem AD Genomics Research Center, Allergy and Clinical Immunology, Internal Medicine, Academia Sinica , 11529 Taipei , Taiwan adidyal@yahoo.com , - - 2013
Background: D-dimer (DD), a fibrin degradation product formed during the lysis of a thrombus, is also detected in high levels in patients with active chronic urticaria (CU). Severe persistent allergic asthma (SPA) is associated with a procoagulant state in the bronchoalveolar space, further aggravated by impaired local activities of the ...
Masuda Yoshiki - - 2013
We encountered a 2-year-old child with life-threatening hypercapnia, with a PaCO2 of 238 mm Hg and severe respiratory and metabolic acidosis, due to status asthmaticus that was refractory to steroid and bronchodilator therapy. Suspecting ventilatory failure and excessive ventilation-induced obstructive shock, we started respiratory physiotherapy in synchrony with her respiration, to ...
Bush Carrie M - - 2013
Background/Aim: To evaluate the role of epidemiologic factors in surgical outcomes for patients with nasal polyposis (NP) and asthma. Methods: Data was prospectively collected on patients who underwent endoscopic sinus surgery over a 7-year period. Among patients with chronic rhinosinusitis (CRS) with NP and asthma, surgical outcomes were analyzed according ...
Passali Giulio Cesare - - 2013
Abstract Conclusion: Early intervention may change the natural course of allergic rhinitis, preventing the progression to asthma. In particular, immunotherapy guarantees remission of local symptoms and valid protection against local and bronchial complications. Symptomatic treatment represents a valid alternative; it is always to be preferred to abstention from any treatment. ...
Pavord Ian D - - 2013
Patients with severe refractory asthma treated with bronchial thermoplasty (BT), a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle, were followed up for 5 years to evaluate long-term safety of this procedure. To assess long-term safety of BT for 5 years. Patients with asthma aged 18 ...
Topal Erdem - - 2013
Wheezing phenotypes may not be stable, and phenotype transitions may occur over time. This study investigates the natural course of episodic viral wheezing (EVW) and identifies the risk factors that predict persistence of wheezing through short-term follow-up. The medical records of children <3 years of age at hospital admission and ...
Yasin F F Department of Paediatric Emergency Medicine, AMNCH, Tallaght, Dublin 24. - - 2013
Asthma guidelines should be followed closely to ensure improvement and consistency of outcome. In order to measure compliance with local acute asthma protocols, we reviewed notes of children presenting to our ED with acute asthma. We noted clinical assessment of severity of asthma exacerbation, compared management of cases with local ...
Ater Dorit - - 2013
Most preschoolers with viral wheezing exacerbations are not atopic. To test in a prospective controlled trial whether wheezing preschoolers presenting to the ED are different from the above in three different domains defining asthma: the atopic characteristics based on stringent asthma predictive index (S-API), the characteristics of bronchial hyper-responsiveness (BHR), ...
Shimoda Terufumi - - 2013
Background: Bronchial asthma is mainly controlled by inhaled corticosteroid (ICS) treatment, and discontinuation of ICS treatment can worsen asthma symptoms and reduce respiratory function. However, the longitudinal impact of ICS on lung function in adult patients is unknown. Methods: To determine whether regular ICS treatment can prevent long-term lung function ...
Fırıncı Fatih - - 2013
Atorvastatin is a statin group medicine that reduces the level of serum cholesterol; thus it is used to treat hypercholesterolaemia. Independent of the cholesterol-lowering property of statins they also have anti-inflammatory and immunomodulating effects. This study aimed to investigate the effect of atorvastatin on histological changes in the lungs in ...
Maspero Jorge J Fundación Cidea Allergy and Respiratory Research Unit, Buenos Aires, Argentina. Electronic address: - - 2013
Associations of inhaled corticosteroids (ICS) with bone mineral density (BMD) loss have not been characterized consistently. This randomized, double-blind study assessed effects of mometasone furoate (MF) administered via dry powder inhaler on BMD of patients with persistent asthma. Adults with mild-moderate persistent asthma who did not receive ICS for ≥3 ...
Batra Pete S - - 2013
Objectives/Hypothesis: The objective of this study was to construct the clinical profile of patients with chronic rhinosinusitis (CRS) with/without polyposis undergoing revision sinus surgery and to evaluate the relationship of polyposis, asthma, aspirin (ASA) sensitivity, inhalant allergies, and previous sinus surgery on disease severity as measured by objective parameters. Study ...
Alansari Khalid - - 2013
Determine whether dexamethasone treatment added to salbutamol reduces time to readiness for discharge in patients with bronchiolitis and possible asthma.METHODS:We compared efficacy and safety of dexamethasone, 1 mg/kg, then 0.6 mg/kg for 4 more days, with placebo for acute bronchiolitis in patients with asthma risk, as determined by eczema or ...
Wechsler Michael E ME Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colo. Electronic address: - - 2013
Bronchial thermoplasty (BT) has previously been shown to improve asthma control out to 2 years in patients with severe persistent asthma. We sought to assess the effectiveness and safety of BT in asthmatic patients 5 years after therapy. BT-treated subjects from the Asthma Intervention Research 2 trial (ClinicalTrials.govNCT01350414) were evaluated ...
Maselli Diego Jose - - 2013
BACKGROUND: Omalizumab is approved for patients with poorly controlled asthma with serum IgE levels between 30 and 700 IU/mL and positive test results for perennial allergens. Its efficacy in patients with IgE levels greater than 700 IU/mL is unclear. OBJECTIVE: To evaluate the response of asthmatic patients treated with omalizumab ...
Chen Feng-Hong - - 2013
Objective: The aims of this interventional were to evaluate the efficacy of functional endoscopic sinus surgery (FESS) -oriented multimodality treatment in chronic rhinosinusitis (CRS) patients with asthma and its impact on asthma. Study Design: Prospective, non-randomized cohort. Methods: Twenty-seven CRS patients with asthma who underwent FESS with postoperative topical corticosteroid ...
Busaba Nicolas Y - - 2013
OBJECTIVE: To determine the change in the clinical presentation of inflammatory paranasal sinus disease as a function of a patient's age. STUDY DESIGN AND METHODS: This is a prospective study of 514 adult patients who presented with inflammatory paranasal sinus disease. The patients were divided into three age groups: group ...
Alcoforado Luciana - - 2013
While administration of medical aerosols with heliox and positive airway pressure are both used clinically to improve aerosol delivery, few studies have differentiated their separate roles in treatment of asthmatics. The aim of this randomized, double blinded study is to differentiate the effect of heliox and oxygen with and without ...
Myers Robert P - - 2013
OBJECTIVES:Rituximab, an anti-CD20 monoclonal antibody that selectively depletes B cells, has shown promise in autoantibody-associated, immune-mediated disorders. As ursodeoxycholic acid (UDCA) is not successful in all patients with primary biliary cirrhosis (PBC), additional treatment options are necessary. The objective of this study was to assess the safety and efficacy of ...
Barnes Neil - - 2013
Objective: To evaluate the 'real world' effects of the monoclonal antibody omalizumab when used to treat severe persistent allergic asthma in UK clinical practice. Methods: A 10 centre retrospective observational study compared oral corticosteroid (OCS) use and exacerbation frequency in 12 months pre- vs 12 months post-omalizumab (OMB) initiation in ...
Peng Hua - - 2013
ObjectiveAlthough the effect of specific immunotherapy (SIT) on allergic rhinitis (AR) has been well documented in developed countries, its long-term efficacy in patients in developing countries (such as China) is poorly understood. This study investigated the long-term therapeutic and preventive effects of SIT on house dust mite (HDM)-induced AR in ...
Azadeh Natalya - - 2013
OBJECTIVE: Primary pulmonary coccidioidomycosis can often be associated with hypersensitivity symptoms treatable with a short course of palliative corticosteroids. Long-term use of corticosteroids is a known risk factor for severe or disseminated infection but the effects of short-term use are not known. METHODS: A retrospective review was conducted of immunocompetent ...
Ozgür Eylem Sercan - - 2013
Objective: Several clinical studies have demonstrated omalizumab effectiveness in patients with severe allergic asthma but the treatment period has always been relatively short (4-12 months). Only a few data is present for long-term omalizumab therapy. We aimed to assess the long-term clinical and functional effectiveness of omalizumab treatment in severe ...
Hossain A S - - 2013
The use of nebulized Ipratropium bromide, quaternary anticholinergic bronchodilators in combination with beta-agonist for the treatment of acute asthma in adults is controversial. In a view of different recommendation the present study is undertaken in Bangladeshi patients. Combination of inhaled Ipratropium bromide and Salbutamol provides greater bronchodilatation than mono therapy ...
Bandyopadhyay Ankan - - 2013
Currently treatment decisions in asthma are governed by clinical assessment and spirometry. Sputum eosinophil, being a marker of airway inflammation, can serve as a tool for assessing severity and response to treatment in asthma patients. To establish correlation between change in sputum eosinophil count and forced expiratory volume in one ...
Agrawal Sanjay - - 2013
Obstructive sleep apnea (OSA) is often not diagnosed in patients presenting for surgical procedures thereby increasing the incidence of adverse perioperative course. Early diagnosis of this disease is important in modifying anesthetic management as well as utilizing specific means which may decrease the complications and improve the patient outcome. Patients ...
Papi Alberto - - 2013
According to international treatment guidelines, inhaled rapid-acting β2 agonists should be used for the control of symptoms in patients with asthma. We compared the efficacy and safety of an extrafine combination inhaler containing a corticosteroid (beclometasone) plus a rapid-onset, long-acting β2 agonist (formoterol) with a short-acting β2 agonist (salbutamol) as ...
Nagaoka Eiki - - 2013
Purpose: Postoperative atrial fibrillation (AF) is a common complication of cardiac surgery that is associated with an increased incidence of other complications. The goal of this prospective randomized study was to evaluate the effect of ultra-low dose landiolol hydrochloride for prevention of AF after off-pump coronary artery bypass grafting (CABG).Methods: ...
Busse William W WW Department of Medicine, University of Wisconsin, Madison, WI, USA. - - 2013
The inhaled corticosteroid fluticasone furoate (FF) in combination with the long-acting β2 agonist vilanterol (VI) is in development for asthma and chronic obstructive pulmonary disease. To assess the safety and tolerability of FF/VI over 52 weeks in patients with asthma. Patients (aged ≥12 years; on inhaled corticosteroid) were randomised (2:2:1) ...
Frati Franco - - 2013
Evaluation of: Stelmach I, Sobocinska A, Majak P, Smejda C, Jerzynska J, Stelmach W. Comparison of the long-term efficacy of 3- and 5-year house dust mite allergen immunotherapy. Ann. Allergy Asthma Immunol. 109, 274-278 (2012). Allergen-specific immunotherapy (SIT) is the only treatment of allergic diseases able to maintain its efficacy ...
Krebs Steven E - - 2013
OBJECTIVES: This study aimed to assess the safety and efficacy of a high-dose continuous nebulized albuterol (CNA) protocol for treatment of asthma in the pediatric emergency department (ED). A secondary objective included a cost-benefit analysis of protocol use. METHODS: In this retrospective chart review, we compared cohorts of patients treated ...
Rodríguez-Martínez Carlos E - - 2013
Introduction: The choice between the different treatments available can have a great impact on the costs of asthma. Objectives: The objective of this study was to estimate the incremental cost-utility ratio of three inhaled corticosteroids (ICs): budesonide (BUD), fluticasone propionate (FP) and ciclesonide, compared to beclomethasone dipropionate (BDP) (the only ...
de Llano Luis Pérez - - 2013
Aim. To evaluate the effectiveness of omalizumab in non-atopic asthma. Methods. Using data from a multicenter registry of severe asthma, we evaluated and compared the clinical outcome of 29 omalizumab-treated severe non-atopic asthmatics with 266 omalizumab-treated severe allergic asthmatics. Effectiveness was assessed by considering severe exacerbations, pulmonary function, the Global ...
Talini D - - 2013
Background: Long-term follow-up of diisocyanate-induced occupational asthma has been occasionally reported. Methods: We studied the outcome of toluene diisocyanate (TDI)-induced asthma in 46 patients at diagnosis and after a follow-up of 11 ± 3.6 years. Symptoms, anti-asthma therapy, forced expiratory volume in 1 s (FEV(1)) and bronchial hyperresponsiveness to methacholine ...
Cresta Federico - - 2013
The aim of the paper is to report the case of a boy affected by cystic fibrosis, with non-ABPA-related recurrent wheezing and frequent pulmonary exacerbation during childhood, who had been  inhaling 7% NaCl+0.1% hyaluronic acid (HA) as a maintenance therapy. We reviewed patient database and, analysing a 7-year follow-up, considered ...
Ahmed S - - 2013
This study compared the efficacy and safety of nebulized magnesium sulphate with salbutamol to normal saline with salbutamol as the initial treatment of severe acute asthma patients. The present study was designed as a randomized open controlled clinical trial. The study was conducted Mymensingh Medical College Hospital over a period ...
Nishiyama Tomoki - - 2013
Some reports showed allergic reaction to propofol. However, propofol has bronchodilating effect. The purpose of this study was to elucidate whether propofol is safely used for patients with allergy or bronchial asthma. Seventy females with bronchial asthma or allergic diseases and 70 females without any allergic diseases for mastectomy were ...
Li-Dong Sun - - 2013
To study the clinical effect of body mass index (BMI) in the optimal time of weaning from sequential invasive-noninvasive mechanical ventilation (MV) by treating severity chronic obstructive pulmonary disease (COPD) patients. 94 patients with severity COPD were divided into the control group (BMI<21) and the study group (BMI>21). These two ...
Cheng Shih-Lung SL Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, - - 2013
Uncontrolled asthma is characterized by considerable variability. Well controlled asthma is associated with less unplanned use of health care resources and fewer acute exacerbations. In this study, we attempted to increase inhaled corticosteroid (ICS) doses initially in suboptimally controlled asthmatics, hypothesizing that early achievement of asthma control using this strategy ...
Gao Shao-Yong - - 2012
This study investigated the rapid onset of bronchodilation effect and compared lung function changes following budesonide/formoterol (Symbicort Turbuhaler®) inhalation in Chinese patients with moderate-severe chronic obstructive pulmonary disease (COPD) and bronchial asthma. In this open-label, parallel-group clinical study, patients eligible for study were divided into COPD group (n=62, mean age ...
Qi Guang-Sheng - - 2012
Objective. Although spirometry is the most common method for evaluating the airway obstruction stage in asthma patients, it is difficult to perform in some patients. The aim of this study was to evaluate whether impulse oscillometry, an easy-to-perform technique, can detect asthmatic airway obstruction stage. Methods. A total of 80 ...
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