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Sherif Camillo C Department of Neurosurgery, Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030, Vienna, Austria, - - 2015
Delayed vasospasm (VSP) following aneurysmal subarachnoid hemorrhage (aSAH) remains a major source of morbidity. Milrinone was recently suggested as an invasive VSP treatment option. It is a phosphodiesterase III inhibitor with vasodilating and additional positive inotrope and anti-inflammatory effects. In this preliminary series, we included patients with severe VSP and ...
Nakagawa Ai A aDivision of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai bDivision of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Chiba cCore Research Facilities for Basic Science, Research Center for Medical Sciences, Jikei University School of Medicine, Minato-ku dJikei University School of Medicine Katsusika Medical Center, Division of Gastroenterology and Hepatology, Katsushika-ku eDivision of Gastroenterology and Hepatology, Nippon Medical School, Bunkyo-ku, Tokyo, - - 2014
This study investigated the relationship between hepatitis C virus (HCV) dynamics and sustained virological response (SVR), as well as the efficacy of an extended treatment with telaprevir-based triple therapy among patients with chronic hepatitis C genotype 1b. Among 220 patients receiving triple therapy for 24 weeks, the SVR rate was ...
Pellicano R R Department of Gastroenterology and Hepatology San Giovanni Battista (Molinette) Hospital Turin, Italy - - - 2014
Functional dyspepsia, though benign, leads to deterioration of the quality of life and high costs for healthcare systems. The optimal therapy for functional dyspepsia is still to be defined because of its multifactorial pathogenesis. In an open multicentric study of patients with functional dyspepsia, we prospectively evaluated the benefit of ...
Wolosker Nelson N Hospital Israelita Albert Einstein, São Paulo, SP, - - 2014
Facial hyperhidrosis can lead to serious emotional distress. Video-assisted thoracic sympathectomy resolves symptoms effectively, though it may be associated with compensatory hyperhidrosis, which may be more common in patients undergoing resection of the second thoracic ganglion. Oxybutynin has been used as a pharmacological approach to facial hyperhidrosis but the long-term ...
Truchuelo Maria Teresa MT Dermatology Department, University Hospital Ramón y Cajal Hospital, Madrid, - - 2014
Melasma is a dermatosis with significant repercussions on patients' quality of life, and there is currently no standard treatment. Hydroquinone is deemed the treatment of choice, but its safety has been questioned in certain cases. To determine the efficacy and safety of a new combination of retinoids in the improvement ...
Belhassen S S Division of Otolaryngology-Head and Neck Surgery,University of - - 2014
Objective: To determine the efficacy of intratympanic methylprednisolone injections for treating sudden sensorineural hearing loss. Method: A retrospective chart review was performed to identify patients suffering from sudden sensorineural hearing loss with no recovery after oral steroids. Patients were given up to three intratympanic methylprednisolone injections at one-week intervals. They ...
Berman Casey Melissa CM Goryeb Children's Hospital at Morristown Medical Center, 100 Madison Ave., Morristown, NJ, 07960, USA, - - 2014
Intrathecal baclofen therapy (ITB) has been used in the treatment of spasticity and dystonia. In our pediatric movement disorder clinic, we noted a delay in referral of patients for consideration of ITB. Often, only after years of failed medical therapy, a baclofen pump is considered. This study attempts to investigate ...
Mauri Laura L The authors' affiliations are listed in the - - 2014
Background Dual antiplatelet therapy is recommended after coronary stenting to prevent thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain. Methods Patients were enrolled after they had undergone a coronary stent procedure in which a drug-eluting stent was placed. After 12 months of treatment with ...
Tan Jun J The People's Hospital of Hunan Province, Department of Plastic & Laser Aesthetic Surgery, 1st Affiliated Hospital of Hunan Normal University, Chang-Sha, Hunan, 410005, P.R. - - 2014
The purpose of this clinical paper is to explore the therapeutic effects, healing times, adverse effects, and maintenance periods of using a CO2 fractional laser in the treatment of photoaging in Asian skin. One fractional CO2 laser procedure was performed on the full face in 56 patients with photoaging. Based ...
Garratt Kirk N KN Lenox Hill Hospital, New York, NY - - 2014
-The Dual Antiplatelet Therapy Study (DAPT) compared 12 and 30 months thienopyridine plus aspirin therapy after drug-eluting stents. The TAXUS Libertē Post Approval Study (TL-PAS) contributed TAXUS Liberté paclitaxel-eluting stent (PES) patients treated with prasugrel. -Outcomes for 2191 TL-PAS patients enrolled into DAPT were assessed. The DAPT co-primary composite endpoint ...
Mansouri A A The National Retina Institute, Towson, MD, - - 2014
PurposeTo determine if the severity of diabetic macular edema influences the effectiveness of subthreshold micropulse (STMP) laser treatment.MethodsA total of 63 eyes of 58 patients with diabetic macular edema were divided into two groups based on their initial central foveal thickness (CFT). Group 1 had CFT ≤400 μm, group 2 had ...
Nakagawa Koji K Division of Reproductive Medicine, Sugiyama Clinic, Tokyo, - - 2014
We evaluated the clinical efficacy of immunosuppressive treatment with tacrolimus for repeated implantation failure (RIF) patients who have elevated in T helper (Th1)/Th2 cytokine producing cell ratios. This was a prospective cohort study of treatment for RIF patients (n = 42) with elevated peripheral blood Th1 (CD4(+) /IFN-γ(+) )/Th2 (CD4(+) /IL-4(+) ) ...
Chiou Shang-Ming SM Department of Neurosurgery, China Medical University Hospital, 2, Yuh-Der Road, Taichung, Taiwan, - - 2014
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can improve the life quality of patients with advanced Parkinson disease (PD). However, previous studies have stemmed mainly from Western centers. Present study analyzed the 6-month outcomes of bilateral STN-DBS therapy that were observed during a 9-year period at a Taiwanese ...
Cagnin Annachiara A Department of Neurosciences SNPSRR, University of Padova Medical School, Via Giustiniani 5, 35128, Padova, Italy, - - 2014
Oral donepezil and rivastigmine are two commonly used cholinesterase inhibitors (ChEIs) used in Alzheimer's disease (AD). The rivastigmine transdermal patch formulation has high tolerability profile, allowing patients to achieve optimal therapeutic doses and providing potential advantages over oral ChEIs. This is a 6-month, multicentre, observational efficacy and tolerability study of ...
Bouras Theodoros T Orthopaedic Department, General Hospital of Patras, Tsertidou 1, 26335, Patras, - - 2014
To provide evidence-based data about the aetiology, incidence, diagnosis and treatment of isthmic lumbar spondylolysis and low-grade spondylolisthesis and return to athletic activities in fine athlete. This is a comprehensive literature review. A thorough MEDLINE search in the period from 1973 to 2014 with the keywords: athlete, spondylolysis, low-grade spondylolisthesis, ...
Jeong Byeong-Ho BH Samsung Medical Center, Sungkyunkwan University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Seoul, Korea, Republic of ; - - 2014
Rationale: Although intermittent, three-times-weekly therapy is recommended for the initial treatment of non-cavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. Objectives: To evaluate the clinical efficacy of intermittent therapy compared with daily therapy for nodular bronchiectatic MAC lung disease. Methods: A retrospective cohort study of ...
Simonneau Gérald G Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, and INSERM Unité 999, Le Kremlin-Bicêtre, France - - 2014
Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of inoperable and persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH). In the 16-week CHEST-1 study, riociguat showed a favourable benefit-risk profile and improved several clinically relevant end-points in patients with CTEPH. The CHEST-2 open-label extension evaluated the long-term safety and ...
Park Jung-Min JM Department of Dermatology, School of Medicine, Pusan National University, Busan, - - 2014
Doxycycline is the standard systemic treatment for rosacea. Recently, there have been a few reports on β-adrenergic blockers such as nadolol, carvedilol and propranolol for suppressing flushing reactions in rosacea. To our knowledge, there are no comparative studies of propranolol and doxycycline, and combination therapy using both. The aim of ...
Ierardi Anna Maria AM Interventional Radiology-Department of Radiology, University of Insubria, Viale Borri 57, 21100, Varese, - - 2014
To evaluate safety and clinical efficacy of percutaneous transcatheter embolization (PTE) in the treatment of spontaneous bleedings (SBs) in patients submitted to chronic anticoagulation therapy. From January 2007 to December 2012, 20 patients (mean age 75.8 years, range 68-91 years) with 23 SBs were retrospectively evaluated. Active bleeding was documented by contrast ...
Das Shinjita S Department of Dermatology, Harvard Medical School, Boston, MA, - - 2014
Acne pathogenesis is a multifactorial process that occurs at the level of the pilosebaceous unit. While acne was previously perceived as an infectious disease, recent data have clarified it as an inflammatory process in which Propionibacterium acnes and innate immunity play critical roles in propagating abnormal hyperkeratinization and inflammation. Alterations ...
Chocova Z Z Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, U nemocnice 2, 128 08, Prague, Czech Republic, - - 2014
Rituximab (RTX) was reported effective in ANCA-associated vasculitis (AAV). We aimed to evaluate clinical efficacy of RTX in AAV along with its impact on immunological parameters. Eighteen RTX-treated AAV patients (M/F 11/7; median age 37.5; 15× PR3-ANCA, 3× MPO-ANCA; 16× relapsing/refractory, 2× first-line therapy) were enrolled. Clinical response, ANCA, total ...
Sastre-Garriga J J Servei de Neurologia / Neuroimmunologia, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain - - 2014
A pseudoatrophy effect has been held responsible for the lack of net impact of natalizumab on brain volume outcomes in 2-year trials, but no data are available beyond 24 months. We aimed to investigate brain volume dynamics in natalizumab-treated patients in up to 3 years after therapy initiation with clinical ...
Abdulaal Marwan R - - 2014
To assess the efficacy and safety of early one-step transepithelial photorefractive keratectomy (PRK) with mitomycin C as treatment for buttonhole formation during LASIK. Eight patients who developed a buttonhole during LASIK with mechanical or femtosecond flap creation underwent one-step transepithelial PRK a few days after the formation of the buttonhole. ...
Parodi M Battaglia MB Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milano, Italy, - - 2014
To compare the effects of subthreshold grid laser treatment (SGLT) and intravitreal bevacizumab injection (IVBI) for the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO) recurring after conventional grid laser photocoagulation. Thirty-five eyes were considered in this prospective, randomised, interventional study and treated with micropulse diode ...
Liu Zhihong - - 2014
Treatment of lupus nephritis (LN) remains challenging. To assess the efficacy and safety of a multitarget therapy consisting of tacrolimus, mycophenolate mofetil, and steroid compared with intravenous cyclophosphamide and steroid as induction therapy for LN. 24-week randomized, open-label, multicenter study (ClinicalTrials.gov number: NCT00876616). 26 renal centers in China. Adults (age ...
Zhang Wenwen W Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, People's Republic of - - 2014
Several observational studies have demonstrated that lipid-modifying therapy may improve long-term survival in abdominal aortic aneurysm (AAA) patients after repair. We carried out a systematic review and meta-analysis of studies evaluating the effect of lipid-modifying therapy on long-term mortality. We conducted a systematic search of multiple databases up to April ...
Bor Renáta R First Department of Medicine, University of Szeged , Szeged , - - 2014
Abstract Background and aims. Recently, anti-TNF-alpha therapy has increasingly been used in the treatment of perianal Crohn's disease (PCD), but there is only limited data regarding its short- and long-term efficacy. Material and methods. The medical records of 68 patients treated with anti-TNF-alpha for PCD were assessed retrospectively. Rate of ...
Oksiuta Marzanna M Medical University of Bialystok, Pediatric Surgery Department, Waszyngtona 17, 15-274 Białystok, - - 2014
Abstract Infantile hemangiomas (IH) are neoplastic proliferations of endothelial cells which occur with an incidence of 10 to 12%. IH rapidly growing and found in cosmetically sensitive areas or complicated with ulcerations are of special concern of parents. Methods: A review of medical charts was performed for newborns treated with ...
Ota Kazuhiro K Second Department of Internal Medicine, Osaka Medical College , Takatsuki, Osaka , - - 2014
Abstract Objectives: Although drug treatment is the usual first-line therapy for gastroesophageal reflux disease (GERD), not all patients receive satisfactory relief from drug therapy, alone. We developed an endoscopic fundoplication technique using endoscopic submucosal dissection (ESD); the technique is referred to as ESD for GERD (ESD-G). This study investigated the ...
Mermerkaya Musa Ugur - - 2014
Various treatment strategies for low-grade chondrosarcomas with variable outcomes have been reported in the literature. The aim of this study was to assess the oncological and functional outcomes associated with intralesional curettage followed by adjuvant therapy comprising high-speed burring, thermal cauterization, and bone cementation with polymethylmethacrylate. We performed a retrospective ...
Yang Jun J Hangzhou, China ; - - 2014
Background: Antithyroid drug (ATD)-induced severe hepatotoxicity is a rare but serious complication of ATD therapy. The characteristics of severe hepatotoxicity have been reported in only a small number of patients. Method: We studied 90 patients with ATD-induced severe hepatotoxicity presenting during a 13 year period (2000-2013) who were about to ...
Riordan John J Department of Anaesthesia, Intensive Care and Pain Medicine, St. Vincent's University Hospital, Dublin, - - 2014
Intrathecal baclofen is an established method of treating spasticity. However, this therapy is not without significant morbidity and mortality. The known morbidity associated with intrathecal pumps includes death, infection, and sepsis including central nervous system infection, accidental overdose, wrong drug administration as well as technical failures such as pump or ...
Garcia Rodrigue R LIRYC, L'Institut de rythmologie et modélisation cardiaque, Avenue du Haut-Lévêque, Bordeaux Pessac Cedex, 33400, France, - - 2014
Little is presently known about the outcome of atrial lesions performed with high-intensity focused ultrasound (HIFU) for atrial fibrillation ablation. We aimed to assess endocardial atrial lesions 6 months after epicardial HIFU ablation (Epicor(™)) and to evaluate the benefit of a combined ablation approach. Thirty patients (21 males, mean age 68 ± 12 years ...
Tschugg Anja - - 2014
Cervical radiculopathy caused by spondylotic foraminal stenosis may require surgical treatment. Surgical options include anterior cervical foraminotomy and fusion or posterior cervical foraminotomy. Controversy remains regarding the preferable surgical approach. Pertinent clinical evidence is limited to low-quality observational reports. Therefore, treatment decisions are predominantly based on the individual surgeon's preference ...
Wenzl Heimo H HH Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria, - - 2014
Many patients with quiescent Crohn's disease are maintained on long-term treatment with azathioprine (AZA), but controlled data are limited. We aimed to evaluate the efficacy of AZA therapy for more than 4 years to maintain clinical remission. We performed a randomized double-blind placebo-controlled AZA withdrawal trial with a follow-up period of ...
Gianniou C C Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, - - 2014
PurposeThe purpose of this study was to report the 2-year outcome of an individually tailored 'observe-and-plan' treatment regimen for neovascular age-related macular degeneration (nAMD), and to investigate its clinical value in terms of functional outcome. This regimen aimed to reduce the clinical burden (visits) by employing individually fixed injection intervals, ...
Secher Rikke Gry RG Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, - - 2014
Introduction : Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. Aim : To examine the effect of 2 years of ...
Geetha Duvuru D Division of Nephrology and Division of Rheumatology, Johns Hopkins University, Baltimore, - - 2014
Rituximab (RTX) is non-inferior to cyclophosphamide (CYC) followed by azathioprine (AZA) for remission-induction in severe ANCA-associated vasculitis (AAV), but renal outcomes are unknown. This is a post hoc analysis of patients enrolled in the Rituximab for ANCA-Associated Vasculitis (RAVE) Trial who had renal involvement (biopsy proven pauci-immune GN, red blood ...
Stemberger M M Dr. med. Michaela Stemberger, Haemophilia Treatment Centre, University of Munich, Ziemssenstr.1, 80336 Munich, Germany, Tel. +49/(0)89/51 60 76 96, Fax +49/(0)89/51 60 75 56, E-mail: - - 2014
Climbing has a low risk of injury and strengthens the entire musculature. Due to its benefits in physical and mental health as well as its high fun factor climbing is an established way of therapy. So far, the usefulness of climbing therapy has not been shown for people with haemophilia ...
Holstein K K Dr. Katharina Holstein, II. Medizinische Klinik und Poliklinik, Universitätsklinikum Eppendorf, Martinistr. 52, 20246 Hamburg, Germany, Tel. +49/(0)40/741 05-24 53, Fax -5193, E-mail: - - 2014
Immune tolerance induction (ITI) in patients with haemophilia B and inhibitors may be complicated by anaphylactic reactions and nephrotic syndrome with lower success rates than in haemophilia A (25% vs. 50-90%). According to case reports, immunosuppressive therapy in addition to high doses of factor IX (FIX) appears to be promising. ...
Scalone G G Thorax Institute. Department of Cardiology. IDIBAPS: Institut d'Investigacions BiomediquesAgust Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona - - - 2014
Bioresorbable vascular scaffolds (BVS) are considered the fourth revolution in Interventional Cardiology, thus promising to address some of the pending issues with current--generation drug eluting stents (DES). Notably, most of the potential advantages of BVS over other current devices are due to a peculiar vascular response, called "vascular restoration therapy". ...
Lim Jennifer I JI Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Illinois Eye and Ear Infirmary, Marion Schenk Esq Chair, Chicago, Illinois, - - 2014
To investigate safety and evidence of efficacy of IBI-20089, an intravitreal, liquid, sustained drug delivery system formulated with triamcinolone acetonide (TA) in combination with ranibizumab (Lucentis) for neovascular age related macular degeneration. Patients received a single intravitreal injection of IBI-20089 containing either 6.9 mg (25 µL) TA or 13.8 mg (50 µL) TA followed ...
Lygidakis N N NN Private Paediatric Dental Clinic, 2 Papadiamantopoulou Street, 11528, Athens, - - 2014
To evaluate the clinical outcome of a treatment protocol performed in children with unerupted permanent maxillary central incisors, including surgical removal of any related obstruction and traction initiation in one stage, under fully repositioned flap, combined with pre- and post-operative orthodontics for space creation and final alignment. Forty-six patients aged ...
Wang Hongfei H No.1 Hospital of China Medical University, Dermatology, Shenyang, China. - - 2014
This meta-analysis was designed to compare the efficacy, cosmetic outcome and safety of photodynamic therapy (PDT) with other procedures for the treatment of primary basal cell carcinoma (BCC). A computerized search through electronic databases was performed to search for relevant randomized controlled trials (RCTs) published before October 2013. Only RCTs ...
Akinwande Olaguoke K OK Department of Interventional Radiology, University of Louisville Hospital, Louisville, KY, USA, - - 2014
To compare the feasibility, safety, and efficacy with small and large irinotecan drug-eluting beads (DEBIRI) for treating hepatic colorectal metastases. Using our prospectively maintained, multi-center, intra-arterial therapy registry, we identified 196 patients treated with a combination of large beads (100-300 to 500-700 μm) and patients treated with a combination of small ...
Sheedy Kellen C KC Loyola - - 2014
Objective: Injectable osteoporosis drugs are increasing in popularity due to their efficacy and convenient administration. In this retrospective comparison of the two available treatments, denosumab (Prolia®) and zoledronic acid (ZA, Reclast®), we aimed to determine and compare the efficacy and tolerability of denosumab and ZA.Methods: The charts of patients who ...
Poerner Tudor C TC From the 1st Department of Medicine, Division of Cardiology, University Hospital of Jena, Jena, Germany (T.C.P., S.O., J.G., K.N., F.J., B.G., C.J., H.R.F.); and Clinical and Experimental Interventional Cardiology, Internal Medicine III, University of Saarland, Saarbrücken, Germany - - 2014
In this randomized trial, strut coverage and neointimal proliferation of a therapy of bare metal stents (BMSs) postdilated with the paclitaxel drug-eluting balloon (DEB) was compared with everolimus drug-eluting stents (DESs) at 6-month follow-up using optical coherence tomography. We hypothesized sufficient stent coverage at follow-up. A total of 105 lesions ...
Yoon Kichul K Department of Internal medicine, Seoul National University Bundang Hospital, Seongnam, - - 2014
Resistance rates of H. pylori to clarithromycin, metronidazole and quinolone are over 30% in S. Korea. Aim of this prospective study was to evaluate the ultimate eradication rate of H. pylori after 1st, 2nd or 3rd line therapy in Korea. A cohort of 2,202 patients with H. pylori was treated ...
Bano Maria M Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, - - 2014
Tricuspid annular plane systolic excursion (TAPSE) has emerged as a novel and reliable measure of right ventricular (RV) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function. A ...
Chandrasekar Thenappan T UC Davis Medical Center, Urology , 4860 Y Street , Suite 3500 , Sacramento, California, United States, 95817 , 916-816-0711 , 916-734-8094 ; - - 2014
Purpose: We created an internet-based survey of patients treated for urolithiasis to evaluate for trends in treatment, outcomes and patient satisfaction, and to establish internet surveys as a feasible medium for future research of patient urolithiasis treatment experiences. Methods and Materials: We used the website "kidneystoners.org" to disseminate the online ...
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