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Hirschl Mirko M Department of Angiology, Hanusch Hospital, Vienna, - - 2014
For decades, heparins and vitamin K antagonists (VKAs) have been the gold standards in therapy of venous thromboembolism (VTE). The advent of factor IIa and Xa inhibitors provides new therapeutic options. The aim of this analysis is to compare the currently available new oral anticoagulants (NOACs) with VKAs and also ...
Forestier Romain J RJ Centre de recherche rhumatologique et thermal, Aix-les-Bains, - - 2014
Physical therapy has not been evaluated much for the treatment of chronic venous insufficiency before. The question is whether balneohydrotherapy and usual care combined is superior to usual care alone. In a randomized trial comparing spa therapy versus waiting list patients were treated on an out-patient basis in a private ...
Sood Ajit A Dayanand Medical College and Hospital, Punjab, - - 2014
Introduction. Standard treatment for patients with chronic hepatitis C genotype 1 (CHC G-1) infection includes pegylated interferon plus ribavirin (PEG-RBV) for 48 weeks. Shorter treatment regimen would be more acceptable due to lower cost and fewer side-effects. We aimed to compare the efficacy of 36 week PEG-RBV therapy with standard ...
Faisal Nabiha N Toronto General Hospital, University of Toronto. Ontario, - - 2014
Introduction. Hepatitis C (HCV) continues to be the leading indication for liver transplantation (LT). Sustained virological response (SVR) rates to pegylated interferon (PEG-IFN) and ribavirin (RBV) therapy for recurrent HCV in Genotype 1 (G1) LT recipients have been disappointing (30-40%). Experience with triple therapy using protease inhibitors (PI) boceprevir (BOC), ...
Vela M F MF Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ, - - 2014
Treatment options for achalasia include oral pharmacologic therapy, endoscopic injection of botulinum toxin, pneumatic dilation, and myotomy (conventionally by laparoscopy, but more recently by an endoscopic approach). Oral pharmacologic agents have fallen out of use because of insufficient efficacy and frequent side effects. Endoscopic injection of botulinum toxin is safe ...
Leybovich Martin - - 2014
This study compared two treatments for mild noncarious cervical lesions (NCCLs): a subepithelial connective tissue graft (CTG) versus a Class V composite resin restoration (CRR). Twenty-six sites with NCCLs were randomly assigned to be treated by CTG or CRR. Periodontal health parameters and dentinal hypersensitivity (DH) were recorded at baseline ...
Levy Jerrold H JH Duke University School of Medicine, Divisions of Cardiothoracic Anesthesiology and Critical Care, Duke University Hospital, 2301 Erwin Road, Durham, NC 27710, USA. Electronic address: - - 2014
Bleeding is a significant complication of anticoagulant therapy. With the emergence of new oral anticoagulants (NOACs; ie, direct factor IIa or Xa inhibitors), this risk is further compounded by the lack of validated reversal strategies for these agents. Emerging postmarketing evidence suggests that the bleeding risks are in line with ...
Stone Scellig S D SS Department of Neurosurgery, Boston Children's Hospital, Boston, - - 2014
Object Combined endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) enhances the likelihood of shunt freedom over ETV alone, and thus avoidance of shunt-related morbidity, in hydrocephalic infants. To date, virtually all published reports describe experiences in Africa, thus hampering generalization to other parts of the world. Here, the authors ...
Lorenz Katrin K Johannes Gutenberg-University Mainz, Mainz University Medical Center, Department of Ophthalmology , Langenbeckstr. 1, 55131 Mainz , Germany +49 6131 174069 ; +49 6131 1747 4069 ; - - 2014
Introduction: Lowering intraocular pressure (IOP) is at present the only therapeutic approach to the treatment of glaucoma proven to be successful. The choice of therapy must take into account efficacy, tolerability, safety, quality of life, adherence and cost. Monotherapy fails to achieve a satisfactory IOP reduction in 40 - 75% ...
Taveira-DaSilva Angelo M - - 2014
Background.Combined simvastatin and sirolimus therapy reduce TSC2-null lesions and alveolar destruction in a mouse model of lymphangioleiomyomatosis (LAM), suggesting that therapy with both drugs may benefit LAM patients. Methods.To determine whether simvastatin changed the prevalence of adverse events or altered the therapeutic effects of sirolimus, we recorded adverse events and ...
Ernst M M Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Haus Ost 22 (O 22), Martinistr. 52, 20246, Hamburg, Germany, - - 2014
The treatment mode in acute vertebrobasilar occlusion (VBO) remains uncertain. We analyzed efficacy and safety of intravenous glycoprotein IIb/IIIa inhibitor (IV GPI) plus subsequent intra-arterial thrombolysis with or without additional endovascular mechanical therapy (percutaneous transluminal angioplasty/stenting or thrombus aspiration) and sought treatment factors that predict good clinical outcome. We retrospectively ...
Liang Chih-Ming - - 2014
Background: Quinolone-containing triple therapy is recommended as an option for non-bismuth containing second-line Helicobacter pylori eradication. Current available Taiwanese reports in the literature used 7-day quinolone-containing triple therapy. As a result, some physicians still prescribe 7-day regimens in real-world practice in Taiwan. This study aimed to further assess the appropriateness ...
Huizinga T W J TW Department of Rheumatology, Leiden University Medical Center, Leiden, The - - 2014
To assess the efficacy and safety of tocilizumab (TCZ) plus methotrexate/placebo (MTX/PBO) over 2 years and the course of disease activity in patients who discontinued TCZ due to sustained remission. ACT-RAY was a double-blind 3-year trial. Patients with active rheumatoid arthritis despite MTX were randomised to add TCZ to ongoing MTX ...
Reddy Ashvini K AK *Department of Ophthalmology, University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, Florida; and †Department of Ophthalmology, Emory University, Atlanta, - - 2014
To determine whether serial ranibizumab injections are effective in the treatment of cystoid macular edema in patients with chronic controlled noninfectious uveitis. Five eyes of 5 patients were included in a prospective noncomparative therapeutic trial. They received intravitreal injections of ranibizumab at Day 0 and were followed monthly for 1 ...
Dinglas Victor D VD Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine , 1800 East Monument St. , 5th Floor, Pulmonary , Baltimore, Maryland, United States, 21205, Johns Hopkins University, Outcomes After Critical Illness and Surgery (OACIS) Group, Baltimore, Maryland, United States ; - - 2014
Rehabilitation started early during an intensive care unit (ICU) stay is associated with improved outcomes and is the basis for many quality improvement (QI) projects showing important changes in practice. However, little evidence exists regarding whether such changes are sustainable in real-world practice. To evaluate the sustained effect of a ...
Stoppe Christian - - 2014
Cardiac surgery has been shown to result in a significant decrease of the antioxidant selenium, which is associated with the development of multiorgan dysfunction and increased mortality. Thus, a large-scale study is needed to investigate the effect of perioperative selenium supplementation on the occurrence of postoperative organ dysfunction. We plan ...
Nguyen Nghia H NH School of Medicine at University of California, San Diego, San Diego, CA, - - 2014
Suboptimal viral suppression with adefovir (ADV) poses a challenge in managing chronic hepatitis B (CHB). Few studies have evaluated the efficacy of entecavir (ETV) in ADV-experienced patients. Our aim is to assess treatment effectiveness of ETV in ADV-experienced patients. ADV-experienced patients switched to ETV were enrolled from six U.S. clinics. ...
Nakada Toshimasa T Department of Pediatrics, Aomori Prefectural Central Hospital, Higashi-Tukurimiti 2-1-1, Aomori City, Aomori Prefecture, 030-8553, Japan, - - 2014
This retrospective study aimed to investigate the effects of anti-inflammatory drugs (ADs) on intravenous immunoglobulin (IVIG) therapy in the acute phase of Kawasaki disease. In total, 182 pediatric patients who received IVIG therapy for Kawasaki disease between 1999 and 2013 at the Department of Pediatrics, Aomori Prefectural Central Hospital were ...
Choi Hyo Jin HJ Division of Rheumatology, Department of Internal Medicine, Gachon University Gil Hospital, Incheon, - - 2014
To evaluate treatment patterns and clinical factors affecting gout flare in South Korea. We retrospectively examined data from 401 patients seen at nine rheumatology multicenter clinics, under urate lowering therapy (ULT) more than 6 months after stopping prophylactic medication. Demographic data, clinical and laboratory features were collected at the initiation of ...
Jahangiri Azadeh A Department of Physical Medicine and Rehabilitation, Islamic Republic of Iran Army University of Medical Sciences, Tehran, Iran, - - 2014
To compare the advantages of prolotherapy in the treatment of first carpometacarpal osteoarthritis (OA) with those of corticosteroid local injection in the short and long term. We performed a randomized controlled trial from March 2010 to March 2011 in an outpatient clinic at a university hospital. Sixty participants (60 hands) ...
Shah Rachit M RM Cardiac Electrophysiology, Department of Cardiology, Virginia Commonwealth University Hospital, Gateway Building, 3rdFl, PO Box 980053, Richmond, VA 23298-0053, - - 2014
Cardiac-resynchronization therapy (CRT) reduces morbidity and mortality in patients with chronic systolic heart failure (SHF) and a wide QRS complex. It is unclear whether the same benefit extends to patients with QRS duration (QRSd) <130 ms. Our aim was to perform a meta-analysis of all randomized controlled trial (RCTs) and ...
Colombel Md Jean-Frederic JF Department of Gastroenterology, Icahn School of Medicine at Mt Sinai, New York, New York, - - 2014
OBJECTIVES:The safety and efficacy of adalimumab for patients with moderately to severely active ulcerative colitis (UC) has been reported up to week 52 from the placebo-controlled trials ULTRA (Ulcerative Colitis Long-Term Remission and Maintenance with Adalimumab) 1 and 2. Up to 4 years of data for adalimumab-treated patients from ULTRA ...
Kargas K K Department of Preventive Dentistry Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
To assess the efficacy of subgingival glycine powder air polishing (GPAP) during supportive periodontal therapy (SPT). Each quadrant of 25 subjects was randomly assigned to the following treatments: subgingival scaling with hand instruments (SRP), GPAP, subgingival ultrasonic debridement (UD) and no subgingival treatment (NT). Clinical recordings included the following: probing ...
Chishimba Livingstone L The University of Manchester; Manchester Academic Health Science Centre; University Hospital South Manchester NHS Foundation Trust, Manchester, - - 2014
Abstract Background And Rationale: Antifungal therapy for severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA) remains poorly studied. We assessed the efficacy and safety of NAB as second and third line therapy in SAFS and ABPA. Methods: 21 adult asthmatics with SAFS (n=11) and ABPA (n=10) who ...
Sun Mou-Jong MJ Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Changhua Christian - - 2014
Data on 32 consecutive women with demonstrable urinary tract dysfunction for at least 6 months following radical hysterectomy (RH) for uterine cervical cancer, who received 24 sessions of extracorporeal magnetic innervation (ExMI) treatment twice-weekly were collected. The 1-h pad test weight decreased from 27.2 g pre-treatment to 12.1 g post-treatment ...
Choi Chun Pil - - 2014
Abstract Background:Despite the effectiveness of low-fluence Q-switched Nd:YAG laser (QSNY) treatment in melasma, adverse events, including mottled hypopigmentation (MH) and rebound hyperpigmentation (RH) have been reported. Objective: To compare the effectiveness and safety of combination therapy using low-fluence QSNY and long-pulse Nd:YAG laser (LPNY) (Dual toning) with low-fluence QSNY monotherapy ...
Lavinsky Daniel D *Department of Ophthalmology, Federal University Rio Grande do Sul, Porto Alegre, Brazil; and †Department of Ophthalmology and Hansen Experimental Physics Laboratory, Stanford University, Stanford, - - 2014
To assess safety and clinical efficacy of the nondamaging photothermal therapy for the macula for the treatment of chronic central serous retinopathy. Sixteen eyes of 16 patients with persistent central serous retinopathy (>4 months of duration) were treated with the PASCAL Streamline) at 577-nm wavelength, using 200-μm retinal spot sizes. ...
Saito Tsukasa T Division of Cardiovascular, Respiratory and Neurology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan, - - 2014
Segmental craniocervical dystonia is characterized by blephalospasm and oromandibular dystonia and is also called Meige syndrome. The current treatment strategy including botulinum toxin (BTX) injections has not yet attained an acceptable level. We describe a long-term favorable response of a novel combination therapy with aripiprazole (ARP), trihexyphenidyl (THP), and BTX ...
Morgia Giuseppe G Department of Urology, University of Catania, Catania, - - 2014
Phytotherapy has been used to treat patients with lower urinary tract symptoms (LUTS). We evaluated the efficacy and tolerability of combination therapy between Serenoa Repens (SeR), Lycopene (Ly), and Selenium (Se) + tamsulosin versus single therapies. PROCOMB trial (ISRCTN78639965) was a randomized double-blinded, double-dummy multicenter study of 225 patients between 55 and ...
Vlachaki Efthymia E Hematological Laboratory, Second Department of Internal Medicine, General Hospital Hippokrateon, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
Background/Aim: Thrombopoietin receptor agonists (romiplostim and eltrombopag) have recently been licensed for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenia (ITP) with an insufficient response to corticosteroids, immunoglobulins or splenectomy. In the present case series, we present 4 nonresponding patients with chronic ITP who achieved maintenance of complete ...
Das-Gupta Emma E Nottingham University Hospitals NHS Trust, Nottingham, - - 2014
Second-line therapy for corticosteroid-refractory or dependent acute graft-versus-host disease remains ill-defined, due to limited efficacy of drugs and evolving clinical trial endpoints. Six month freedom from treatment failure has been proposed as a novel clinical trial endpoint and is defined by the absence of death, malignancy relapse/progression, or addition of ...
Zhang Huabin F - - 2014
IntroductionThis study aimed to describe treatment changes (discontinuation, switching, and therapy add-on) following the initiation of a biologic or nonbiologic oral disease-modifying antirheumatic drugs (DMARDs) in psoriatic arthritis (PsA) patients.MethodsAdult patients with ¿2 PsA diagnoses from physician office visits, initiated on a biologic or non-biologic oral DMARD, were selected from ...
Seitz Anna-Theresa - - 2014
Abstract Background and Objective: Q-switched laser treatments are considered the standard method for removing both regular and traumatic tattoos. Recently, the removal of tattoo ink using ablative fractional lasers has been reported. Ablative fractional CO2-laser and q-switched-ruby laser treatments were used in a split-face mode to compare the safety and ...
Sandborn W J WJ Division of Gastroenterology, University of California San Diego School of Medicine, La Jolla, CA, - - 2014
The efficacy and safety of certolizumab pegol (CZP) in moderate-to-severe Crohn's disease were demonstrated in two 26-week double-blind studies (PRECiSE 1 & 2). To report the safety and efficacy outcomes of long-term, CZP therapy from PRECiSE 3, in which patients received treatment up to 7 years treatment. Patients completing PRECiSE 1 ...
Cosma Dan I DI Department of Paediatric Orthopaedics, University of Medicine and Pharmacy 'Iuliu Haţieganu', Cluj-Napoca, - - 2014
Manipulation and casting according to the Ponseti method are the 'gold standard' for clubfoot treatment, and this method is endorsed by the American Association of Orthopaedic Surgeons. We conducted a retrospective study from January 2004 to December 2012 in our institution. All patients with idiopathic clubfoot were included, and a ...
Onol Fikret Fatih FF Ümraniye Training and Research Hospital, Clinic of Urology, Istanbul, Turkey. Electronic address: - - 2014
We aimed to compare long-term success of desmopressin lyophilisate (DESM-melt) and enuretic alarm (EA) in primary monosymptomatic nocturnal enuresis (PMNE), and to determine predictive factors for success. 142 children with PMNE were randomized to receive DESM-melt or EA treatment for 6 months. Treatment compliance and response were reviewed monthly in ...
Taudorf Elisabeth H EH Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, - - 2014
Non-ablative fractional laser-treatment is evolving for burn scars. The objective of this study was to evaluate clinical and histological long-term outcome of 1,540 nm fractional Erbium: Glass laser, targeting superficial, and deep components of mature burn scars. Side-by-side scar-areas were randomized to untreated control or three monthly non-ablative fractional laser-treatments using ...
Keestra J A J JA Department of Oral Health Sciences, Periodontology, KU Leuven & University of Leuven, Leuven, Belgium; Department of Periodontology, University Hospitals Leuven, Leuven, - - 2014
The purpose of this meta-analysis is to evaluate the effectiveness of different systemic antibiotics in combination with scaling and root planing (SRP) when compared to SRP alone in patients with untreated chronic periodontitis. Although chronic periodontitis is mostly treated without adjunctive systemic antibiotics, some recent meta-analyses have shown clinical benefit ...
Rollan Antonio A Antonio Rollan, Pablo Cortés, Luisa Durán, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7650568, - - 2014
To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature. Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was ...
Marcellin Patrick P Service d'Hépatologie, INSERM-CRB3, Hôpital Beaujon, Clichy, France. Electronic address: - - 2014
This study investigated the antiviral efficacy and safety of telbivudine in combination with pegylated interferon (PegIFN) alpha-2a in chronic hepatitis B (CHB). This was a randomized, open-label, multicenter study, in treatment-naïve patients with HBeAg-positive CHB, comparing the efficacy and safety of telbivudine in combination with PegIFN alpha-2a with telbivudine monotherapy ...
Pisani Antonio A Nephrology, Department of Public Health, University Federico II, Naples, - - 2014
Proteinuria is the predominant risk factor for renal disease progression in Fabry disease (FD). When urine protein excretion is controlled to <0.50 g/24 h, the rate loss of glomerular filtration rate (GFR) is not significantly different from 0. However, enzyme replacement therapy (ERT) alone does not decrease proteinuria and it ...
McMillan Catherine C Division of Plastic and Reconstructive Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, - - 2014
To compare long-term outcomes and retreatment rates for patients with Dupuytren disease who underwent needle aponeurotomy (NA) combined with a series of triamcinolone acetonide injections or underwent NA alone as part of a prior randomized controlled trial. During this follow-up study, 44 of 47 participants in the original study were ...
Inui Takehiko T Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, 20 Shishioto, Akiu Yumoto, Taihaku-ku, Sendai-shi, Miyagi 982-0241, - - 2014
Background: Adrenocorticotropic hormone (ACTH) therapy is the first-line therapy for infantile spasms, and is effective for many other intractable epilepsies. While spasms may respond to ACTH for weeks, a substantial proportion of patients develop recurrent seizures over a yearly period. To maintain efficacy, we treated two children with intractable epilepsy ...
Neoh Sandra L SL Department of Endocrinology, Austin Health, Melbourne, VIC, Australia. - - 2014
To investigate the safety, tolerability and efficacy of combination phentermine and topiramate therapy for maintenance of weight loss. Retrospective audit of patients attending the Austin Health Weight Control Clinic who were dispensed phentermine-topiramate between 22 January 2010 and 16 July 2012 and after reaching a target weight by following a ...
Gordon Jessica J Hospital for Special Surgery, New York, USA. - - 2014
We aimed to assess the long-term safety and tolerability of imatinib in diffuse cutaneous systemic sclerosis (dcSSc). In this open-label, single-arm, extension-phase clinical trial, patients continued imatinib for 24 months following 12 months of initial treatment. Seventeen patients enrolled. Forty of 92 adverse events (AE) and 0/6 serious (S) AE ...
Javois Alexander J AJ Advocate Children's Hospital, Oak Lawn, Illinois; University of Illinois Medical College, Chicago, Illinois. Electronic address: - - 2014
This report describes the immediate, 1-, and 5-year follow-up results of the U.S. Food and Drug Administration Continued Access clinical trial of the GORE HELEX Septal Occluder (W. L. Gore & Associates, Inc., Flagstaff, Arizona) for closure of secundum atrial septal defect. The trial was conducted between May 2003 and ...
Jayakody Himali H Division of Child Neurology, Department of Pediatrics, University of Iowa Children's Hospital, 200, Hawkins Drive, Iowa City, Iowa 52242. Electronic address: - - 2014
Optic neuritis is an important pediatric disorder causing visual impairment. Because of the absence of pediatric-specific studies, data extrapolated from the adult-based optic neuritis treatment trial are used to guide management of pediatric patients. Recent literature promotes a prolonged course of oral steroids to prevent relapses. However, there are no ...
- - 2014
When severe gout with tophi persists despite treatment with allopurinol, a xanthine oxidase inhibitor, the hypouricaemic drug of choice is probenecid, a uricosuric agent, in the absence of a better alternative. Pegloticase is a pegylated recombinant uricase. This enzyme catabolises uric acid into allantoin, a water-soluble substance that is excreted ...
Bogaz Eduardo Amaro EA Department of Otorhinolaryngology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, - - 2014
Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) is defined when a loss of at least 30 dB occurs in over 3 continuous frequencies, in up to 72 hours, of which etiology is not established, despite adequate investigation. Different types of treatment regimens have been proposed, but only glucocorticoids have shown some ...
Qiu Yongbin Y Shandon Medical University, Shandong, - - 2014
To investigate the effect of spa adjuvant therapy on diabetic lower extremity arterial disease (LEAD). 128 patients with type II diabetes were separated into three groups according to the degree of lower extremity vascular stenosis. Patients within each group were then randomly divided to receive no treatment (control) or spa ...
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