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Sherif Camillo C Department of Neurosurgery, Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030, Vienna, Austria, - - 2015
Delayed vasospasm (VSP) following aneurysmal subarachnoid hemorrhage (aSAH) remains a major source of morbidity. Milrinone was recently suggested as an invasive VSP treatment option. It is a phosphodiesterase III inhibitor with vasodilating and additional positive inotrope and anti-inflammatory effects. In this preliminary series, we included patients with severe VSP and ...
Adachi Nobuo N aDepartment of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University bFukuhara Orthopaedic Hospital, Hiroshima, - - 2015
Forty-six severe clubfeet in 29 patients were treated by serial castings, followed by a newly developed dynamic splint. The mean period of splint usage was 59.9 months and the mean period of follow-up was 81.5 months. Of the patients, 76.1% were satisfied, 87.0% had no functional deficit, and 84.8% had ...
Chung M Kyu MK Cooper Medical School of Rowan University, Camden, New Jersey (Dr Chung); Chung Institute of Integrative Medicine (Dr Chung) and Won Sook Chung Foundation (Drs Chung and LaRiccia), Moorestown, New Jersey; New Jersey Chapter of the American Academy of Medical Acupuncture, Morganville, New Jersey (Dr Chung); Center for Clinical Epidemiology and Biostatistics of the Perelman School of Medicine at the University of Pennsylvania, Philadelphia (Dr LaRiccia); Penn-Presbyterian Medical Center and the Hospital of the University of Pennsylvania in the departments of Medicine and Rehabilitation Medicine (Dr - - 2015
Chronic nausea and vomiting of uncertain etiology can be debilitating and uncomfortable for patients while frustrating for clinicians. This article presents the case of a young woman with chronic nausea and vomiting of unknown etiology resulting from body piercing and tattoo scars on body areas that Chinese Medicine asserts are ...
Gupta G G Department of Dermatology, Monklands Hospital, Airdrie, Lanarkshire, - - 2015
Lmax, the maximum lesion count during treatment, is a new concept for evaluating the efficacy of field-directed treatments for actinic keratosis (AK) against clinical and subclinical lesions. Imiquimod 3.75% is a field-directed AK treatment, which can detect and clear clinical and subclinical lesions across an entire sun-exposed field such as ...
Akl Elie A EA Department of Internal Medicine, American University of Beirut, Riad El Solh St, Beirut, - - 2014
Anticoagulation may improve survival in patients with cancer through an antitumor effect in addition to the perceived antithrombotic effect. To evaluate the efficacy and safety of parenteral anticoagulants in ambulatory patients with cancer who, typically, are undergoing chemotherapy, hormonal therapy or radiotherapy, but otherwise have no standard therapeutic or prophylactic ...
Villanueva Vicente V Hospital Universitario y Politécnico La Fe, Bulevard Sur, s/n, Carretera de Malilla, 46026, Valencia, Spain, - - 2014
Many patients with epilepsy are treated with antiepileptic drug (AED) polytherapy. Several factors influence the choice of early add-on therapy, and deciding on the most appropriate drug can be difficult. This study aimed to assess the efficacy and tolerability of lacosamide as early add-on therapy in patients with partial-onset seizures. ...
van Asten Freekje F Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The - - 2014
The HELIOS (Health Economics with Lucentis in Observational Settings) study was designed on request of the Dutch Health Authority for an observational study to assess the effectiveness and safety of ranibizumab for neovascular age-related macular degeneration (wet AMD) in daily practice. The HELIOS study was a 2-year prospective, observational, open-label, ...
Jajarm Hasan Hoseinpour HH Department of Oral Medicine and Dental Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, - - 2014
Recently, photodynamic therapy (PDT) has been suggested as a new treatment option that is free from side effects for erosive-atrophic oral lichen planus (OLP). The purpose of this study was to compare the effect of toluidine blue-mediated photodynamic therapy (TB-PDT) with local corticosteroids on treatment of erosive-atrophic OLP. In this ...
Buzzard Katherine A KA Department of Neurology, Concord Repatriation General Hospital, Concord West, New South Wales, - - 2014
Introduction: Myasthenia gravis (MG) can be refractory to conventional immunotherapy. We report on the efficacy and durability of intravenous remission-induction cyclophosphamide (CYC) followed by oral immunosuppression in refractory MG. Methods: We identified 8 patients from our medical records with moderate or severe refractory MG who were treated with 6 cycles ...
Kranke P P Department of Anaesthesia and Critical Care, University Hospitals of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany - - 2014
Postoperative nausea and vomiting (PONV) is common; ondansetron is often used as prophylaxis or for breakthrough episodes. Vestipitant is a neurokinin 1 (NK-1) receptor antagonist that is effective for prophylaxis, but its efficacy for treating established PONV is unknown. This study was performed to evaluate the efficacy and safety of ...
Lv Peng-Hua PH Peng-Hua Lv, Li-Fu Wang, Department of Interventional Radiology, Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu Province, - - 2014
To evaluate our experience of the clinical management of spontaneous isolated superior mesenteric artery dissection (ISMAD). From January 2008 to July 2013, 18 patients with ISMAD were retrospectively analyzed, including 7 patients who received conservative therapy, 9 patients who received reconstruction with bare stents, and 2 patients who underwent surgical ...
Siramolpiwat Sith S Sith Siramolpiwat, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, - - 2014
Portal hypertension (PH) plays an important role in the natural history of cirrhosis, and is associated with several clinical consequences. The introduction of transjugular intrahepatic portosystemic shunts (TIPS) in the 1980s has been regarded as a major technical advance in the management of the PH-related complications. At present, polytetrafluoroethylene-covered stents ...
Testoni Pier Alberto PA Unit of Gastroenterology and Gastrointestinal Endoscopy, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute - Vita-Salute San Raffaele University, Milan, Italy, - - 2014
Transoral incisionless fundoplication (TIF) with the EsophyX™ device creates an antireflux valve with good functional results in patients with gastro-esophageal reflux disease (GERD). The aim of this study was to assess the long-term effect of TIF 2.0 on pathological reflux and symptoms in GERD patients with daily dependence on proton ...
Hikichi Taiichi T Department of Ophthalmology, Ohtsuka Eye Hospital, Sapporo, - - 2014
To determine predictors of 2-year outcomes after three, monthly, intravitreal ranibizumab (IVR) injections followed by as-needed injections for treatment-naive polypoidal choroidal vasculopathy (PCV). This trial included 85 Japanese patients with symptomatic treatment-naive PCV who received one 0.5 mg IVR injection monthly for 3 months followed by as-needed retreatments. PCV with subfoveal ...
Villa Alessandro A Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, and Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston MA. Electronic address: - - 2014
The mTOR inhibitor sirolimus is effective in reducing incidence of graft-versus-disease (GVHD) following allogeneic hematopoietic stem cell transplantation (HSCT). Agents that inhibit the mTOR pathway are known to be associated with significant and potentially dose-limiting toxicities, including stomatitis. The objective of this study was to report the clinical features and ...
Patrizi Annalisa A Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
Management of patients affected by mastocytoma (MS) includes avoiding triggering factors of mast cell degranulation, and administration of symptomatic treatment. We evaluated topical steroid treatment efficiency on the clinical course of MS in a group of patients, comparing the results with another untreated group.We retrospectively evaluated clinical data of 176 ...
Kim Tae-Hoon TH Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, - - 2014
The efficacy of heparin bridging therapy during the initiation of oral anticoagulation therapy (OAC) in nonvalvular atrial fibrillation (NVAF) is unclear. Objectives: To evaluate the efficacy and the safety of heparin bridging therapy during OAC initiation in NVAF patients. This study included 5,327 consecutive warfarin-naïve NVAF patients who received OAC ...
Reisman Y Y Men's Health Clinic, Amstelland Hospital, Amsterdam, The - - 2014
Low-intensity shockwaves (LISW) are known to produce revascularization and have been in evaluation and in use to treat erectile dysfunction (ED). The present single-arm pilot study is aimed to assess the safety and efficacy of a dedicated shockwave device (Renova) on vasculogenic ED patients. Fifty-eight patients with mild to severe ...
Cavalié Marine M Department of Dermatology, University Hospital of Nice, Nice, - - 2014
Topical or intralesional corticosteroids are referred to as gold standard treatments for keloids. Recent studies showed that ablative fractional laser (AFL) treatment facilitates delivery of topical drug deeply into the skin by creating vertical channels. The objective of the present study was to assess the ablative erbium laser in fractionated ...
Rah Yoon Chan YC Department of Otorhinolaryngology-Head and Neck Surgery, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South - - 2014
To investigate the long-term outcomes of accompanying tinnitus after steroid therapy for patients with sudden sensorineural hearing loss (SSNHL). Retrospective chart review and survey. Fifty patients diagnosed with SSNHL accompanied by tinnitus were enrolled and divided into two groups-satisfied and unsatisfied-according to the degree of improvement of tinnitus after SSNHL ...
Paine Kaitlyn Marie KM From the Department of Plastic Surgery, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, - - 2014
We present a case of multiplanar distraction osteogenesis for the simultaneous treatment of sagittal and unicoronal craniosynostosis in a nonsyndromic 2-month-old boy. Unilateral fronto-orbital advancement and sagittal suturectomy were performed. Distracters were fixed orthogonally in the sagittal and coronal positions to distract the affected coronal and sagittal sutures. The devices ...
Seo Hyun-Min HM *All the authors are affiliated with the Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, - - 2014
Childhood nevus of Ota is likely to be more superficial than the adult nevus, therefore early laser treatment of nevus of Ota might have some beneficial effects in children. To evaluate the beneficial effects of early treatment of nevus of Ota with a low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet ...
Dubey Divyanshu D Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, - - 2014
We evaluated the outcome of multimodality treatment in autoimmune limbic epilepsy in 3 consecutive patients (2 male and 1 female; age 33-55 years) presenting with a combination of focal non-convulsive status epilepticus, memory impairment, and psychosis. MRI showed right or bitemporal T2 or FLAIR hyperintensity. Video-EEG showed seizures of right ...
Wight Sheila S Newcastle upon Tyne NHS Foundation Hospitals Trust, Newcastle upon Tyne, - - 2014
Speaking louder/more intensely represents a longstanding technique employed to manage voice and intelligibility changes in people with Parkinson's. This technique has been formalized into a treatment approach and marketed as the Lee Silverman Voice Treatment (LSVT®) programme. Evidence for its efficacy has been published. Studies to date are dominated by ...
Stuyt Elizabeth B EB Department of Psychiatry, University of Colorado, Denver, Colorado; Circle Program, Colorado Mental Health Institute at Pueblo, Pueblo, - - 2014
Although the prevalence of tobacco use in those in substance abuse treatment is known to be quite high, most treatment programs do not address tobacco. The purpose of this study was to determine substance abuse recovery rates a year after treatment in a fully integrated, 90-day inpatient, dual diagnosis treatment ...
Conti Fabrizio F Lupus Clinic, Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155, 00161, Rome, - - 2014
In the present study, we performed a retrospective study on the indication, efficacy and causes of withdrawal of mycophenolate mofetil (MMF) in patients with systemic lupus erythematosus (SLE). Moreover, a review of the literature concerning the use of MMF in the real life was performed. We recorded data about indications, ...
Britt Nicholas S NS Department of Pharmacy Practice, University of Kansas School of Pharmacy, 3901 Rainbow Boulevard, MS 4047, Kansas City, KS, USA, - - 2014
Clostridium difficile infection (CDI) is a common cause of nosocomial diarrhea. Metronidazole and vancomycin are the primary treatment options for CDI, but increasing rates of antimicrobial resistance and severe, refractory disease have prompted the need for alternative agents. Tigecycline has previously demonstrated favorable in vitro activity against C. difficile isolates, ...
Tepe Gunnar G RodMed Klinikum, Rosenheim, - - 2014
-Drug-coated balloons (DCB) have shown promise in improving outcomes for patients with peripheral artery disease. We compared a paclitaxel-coated balloon with percutaneous transluminal angioplasty (PTA) for the treatment of symptomatic superficial femoral and/or popliteal artery disease. -The IN.PACT SFA Trial is a prospective, multicentre, single-blinded, randomized trial in which 331 ...
Bekker Margreet W A MW Department of Cardiothoracic Surgery, Radboud University Medical Centre, Nijmegen, Netherlands - - 2014
In 2012, the Netherlands Association of Cardiothoracic Surgery accepted the new guidelines of the European Association for Cardio-Thoracic Surgery on antiplatelet and anticoagulation management in cardiac surgery. The aim of our study was to evaluate knowledge and implementation of these guidelines in Dutch cardiothoracic centres 8 months later, specifically after ...
Sherman Joshua M JM From the *Children's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, CA; †Cohen Children's Medical Center of New York, NSLIJ Health System, New Hyde Park, NY; and ‡Connecticut Children's Medical Center, Hartford, - - 2014
Well-managed pain is associated with faster recovery, fewer complications, and decreased use of resources. In children, pain relief is also associated with higher patient and parent satisfaction. Studies have shown that there are deficiencies in pediatric pain management. LET gel (lidocaine 4%, epinephrine 0.1%, and tetracaine 0.5%) is a topical ...
Alberici Federico F Department of Medicine, University of Cambridge School of Clinical Medicine, Vasculitis and Lupus Service, Addenbrooke's Hospital, Cambridge, UK, Department of Clinical and Experimental Medicine, University of Parma, Italy and Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. Department of Medicine, University of Cambridge School of Clinical Medicine, Vasculitis and Lupus Service, Addenbrooke's Hospital, Cambridge, UK, Department of Clinical and Experimental Medicine, University of Parma, Italy and Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. Department of Medicine, University of Cambridge School of Clinical Medicine, Vasculitis and Lupus Service, Addenbrooke's Hospital, Cambridge, UK, Department of Clinical and Experimental Medicine, University of Parma, Italy and Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. - - 2014
ANCA-associated vasculitis (AAV) is characterized by a chronic relapsing course. Rituximab (RTX) is an effective maintenance treatment; however, the long-term outcomes after its discontinuation are unclear. The aim of this study was to explore the long-term outcomes of AAV patients treated with repeat-dose RTX maintenance therapy. AAV patients receiving a ...
Verheye Stefan S Middelheim Hospital, Antwerp, - - 2014
Aims: Renal denervation has emerged as a treatment option for patients with drug-resistant hypertension. This study was designed to assess the safety and effectiveness of the OneShot™ Renal Denervation System. Methods and results: RAPID is a prospective, multicentre, single-arm study which enrolled 50 patients at 11 clinical sites in Europe ...
El-Darouti Mohammad A MA Dermatology Department, Faculty of Medicine, Cairo University, 13th Abrag Othman, Kornish El Maadi, Cairo, 11431, - - 2014
T helper (Th)1 insufficiency was recently found to be related to the pathogenesis of pemphigus vulgaris (PV). Decreased Th1 response was particularly noticed in the early stages of PV. Therefore, administration of interferon alpha in the early stages of aggressive PV may lead to rapid control of the acute stage ...
Yeo Andrea A St George's Hospital, Blackshaw Road, Tooting, London, SW17 0QT, UK, - - 2014
Chronic Achilles tendinopathy is a common overuse injury. There are several modalities of treatment, reflecting difficulties in management. In particular, due to the well-recognised surgical morbidity, treatment has steered towards less invasive routes. Previous studies have targeted pathology either inside or outside the tendon in isolation with varying results. This ...
Dilla Tatiana - - 2014
BackgroundIn schizophrenia, medication adherence is critical to achieve better patient outcomes and to avoid relapses, which are responsible for a significant proportion of total healthcare costs for this chronic illness. The aim of this study was to assess the cost-effectiveness of olanzapine long-acting injection (OLAI) compared with risperidone long-acting injection ...
Mohammad A J AJ Department of Renal Medicine, Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, UK Department of Clinical Sciences, Rheumatology, Lund University, Lund, - - 2014
Conventional treatment of eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss) with glucocorticoids, with or without additional immunosuppressive drugs, is limited by partial efficacy, frequent toxicity and a high relapse rate. Rituximab is a licensed treatment for granulomatosis with polyangiitis and microscopic polyangiitis and is of potential benefit to patients with EGPA. ...
Gao Yang Y Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, P. R. China; Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, the Third Military Medical University, Chongqing, 400037, P. R. China. Electronic address: - - 2014
Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers in clinical practice. More and more doctors use PDT to cure the patients with skin cancer, especially in the elder. The purpose of this study was to evaluate the efficacy and safety of topical PDT using aminolevulinic acid (5-ALA) ...
Hollawell Shane S Associate Clinical Professor, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, and Orthopedic Institute of Central Jersey, Manasquan, NJ. Electronic address: - - 2014
More than 20% of acute Achilles tendon injuries are misdiagnosed, leading to chronic or neglected ruptures. Some controversy exists regarding how to best manage an acute Achilles tendon rupture. However, a general consensus has been reached that chronic rupture with ≥3 cm of separation is associated with functional morbidity and, therefore, ...
Nakagawa Ai A aDivision of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai bDivision of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Chiba cCore Research Facilities for Basic Science, Research Center for Medical Sciences, Jikei University School of Medicine, Minato-ku dJikei University School of Medicine Katsusika Medical Center, Division of Gastroenterology and Hepatology, Katsushika-ku eDivision of Gastroenterology and Hepatology, Nippon Medical School, Bunkyo-ku, Tokyo, - - 2014
This study investigated the relationship between hepatitis C virus (HCV) dynamics and sustained virological response (SVR), as well as the efficacy of an extended treatment with telaprevir-based triple therapy among patients with chronic hepatitis C genotype 1b. Among 220 patients receiving triple therapy for 24 weeks, the SVR rate was ...
Pellicano R R Department of Gastroenterology and Hepatology San Giovanni Battista (Molinette) Hospital Turin, Italy - - - 2014
Functional dyspepsia, though benign, leads to deterioration of the quality of life and high costs for healthcare systems. The optimal therapy for functional dyspepsia is still to be defined because of its multifactorial pathogenesis. In an open multicentric study of patients with functional dyspepsia, we prospectively evaluated the benefit of ...
Wolosker Nelson N Hospital Israelita Albert Einstein, São Paulo, SP, - - 2014
Facial hyperhidrosis can lead to serious emotional distress. Video-assisted thoracic sympathectomy resolves symptoms effectively, though it may be associated with compensatory hyperhidrosis, which may be more common in patients undergoing resection of the second thoracic ganglion. Oxybutynin has been used as a pharmacological approach to facial hyperhidrosis but the long-term ...
Truchuelo Maria Teresa MT Dermatology Department, University Hospital Ramón y Cajal Hospital, Madrid, - - 2014
Melasma is a dermatosis with significant repercussions on patients' quality of life, and there is currently no standard treatment. Hydroquinone is deemed the treatment of choice, but its safety has been questioned in certain cases. To determine the efficacy and safety of a new combination of retinoids in the improvement ...
Atik O Sahap OS Department of Orthopedics and Traumatology, Medicine Faculty of Gazi University, 06500 Beşevler, Ankara, Turkey. - - 2014
There are still some controversial issues regarding total hip arthroplasty including cemented vs. cementless, short stem vs. long stem. A literature review on the currently published survival results of short stems is encouraging and appears to be comparable with that of traditional uncemented stems. However, only few mid-term and long-term ...
Baraf Herbert S B HS From the *Center for Rheumatology & Bone Research, Wheaton, MD; †Reliant Medical Group, Worcester, MA; ‡Savient Pharmaceuticals, Inc, Bridgewater, NJ; §Duke University Medical Center, Durham, NC; and ║The University of Chicago, Chicago, - - 2014
In clinical trials of pegloticase, a PEGylated uricase developed for treatment of gout refractory to conventional therapy, infusion-related reactions (IRs) were the second most frequent adverse event reported. The objective of this study was to provide a detailed account of IRs with pegloticase therapy. Data from 2 replicate, 6-month randomized ...
Sadick Neil S NS *Weill Medical College of Cornell University, New York, New York; †Sadick Research Group, New York, New York; ‡Yale University School of Medicine, New Haven, - - 2014
The increased demand for anti-aging treatments over the past decade has fueled the development of multimodality devices. This allows for more efficacious treatment of dermal defects, excess adiposity, and skin laxity. Radiofrequency (RF) devices are constantly evolving and consequently adding multiple indications for their use. In this article, the authors ...
Suh Dong-Woo DW Department of Dermatology, College of Medicine, Kyunghee University, Seoul, - - 2014
Diphenylcyclopropenone (DPCP) immunotherapy has been used to treat warts, particularly in patients, such as children, who cannot endure treatment-related pain and in patients with large numbers of warts. However, the efficacy of DPCP immunotherapy remains subject to much controversy. Specifically, cure rates and treatment durations have varied across reports, primarily ...
Kosilov Kirill V KV Department of Adaptive Medicine, Humanities Institute of Social Sciences, Far Eastern Federal University, Ayax 10, corp. F-733, Vladivostok, Russian - - 2014
The aim of the study was to increase the efficiency of treatment for severe symptoms of overactive bladder (OAB) with antimuscarinic drugs in elderly men and women. A total of 341 patients over 65 years of age (average age 69.9; 186 women and 155 men) with severe symptoms of OAB ...
Naylor Justine M JM Orthoapedic, Liverpool Hospital, 1871 Sydney, Australia. - - 2014
Objective: To determine whether total knee arthroplasty recipients demonstrating comparatively poor mobility at entry to rehabilitation and who received supervised therapy, had better rehabilitation outcomes than those who received less supervision. Design: Retrospective analysis of randomized trial data. Patients: Total knee arthroplasty participants randomized to supervised (n = 159) or home-based therapy ...
Cerrati Eric W EW Department of Otolaryngology, New York University, New York, New York, USA - - 2014
Infantile hemangiomas are well known for their rapid growth during the first 6 to 9 months of life, followed by a spontaneous but slow involution. The standard of care is to treat these lesions at an early age with propranolol to expedite the involution process; however, surgery still remains an ...
Yegin Ender G EG Department of Gastroenterology, Marmara University Faculty of Medicine, Istanbul, Turkey. - - 2014
The definition of partial virological response (PVR) was proposed because of its clinical relevance. PVR relates to subsequent therapeutic failure which results in the modification of the regimen. Whether this rationale can be applied to all nucleotide analogues (NA) is not clear. This study was undertaken to analyze PVR influence ...
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