Search Results
Results 401 - 450 of 2920
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Cianchini Giuseppe - - 2012
BACKGROUND: Rituximab induces depletion of B cells and has shown efficacy in antibody-mediated autoimmune disorders. In studies on small series of patients with pemphigus, rituximab administration results in significant improvement. However, differences in inclusion criteria, treatment protocols, and follow-up make it difficult to derive uniform conclusions. OBJECTIVES: We sought to ...
Santini Massimo - - 2012
Minimally invasive surgical ablation for atrial fibrillation (AF) has shown good results and low complications incidence. Our objective was to evaluate feasibility and efficacy of this technique in our center. The procedure included pulmonary vein isolation, ganglionic plexi ablation, ligament of Marshall resection, and left atrial appendage exclusion through beating ...
Folvik Geir - - 2012
Abstract Objective. Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive inherited disorder characterized by intermittent episodes of cholestatic jaundice. For the patients, the disease is a physical and psychological challenge. There is no curable treatment, but symptomatic relief is described following treatment with rifampicin or plasmapheresis. Material and ...
Mitjà Oriol - - 2012
BACKGROUND: Yaws-an endemic treponematosis and, as such, a neglected tropical disease-is re-emerging in children in rural, tropical areas. Oral azithromycin is effective for syphilis. We assessed the efficacy of azithromycin compared with intramuscular long-acting penicillin to treat patients with yaws. METHODS: We did an open-label, non-inferiority, randomised trial at Lihir ...
Lurati Massimo - - 2012
Background: Dermatophytes are the main cause of onychomycosis, but various non-dermatophyte moulds (NDMs) are often the infectious agents in abnormal nails. In particular, Fusarium spp. and other NDMs are mostly insensitive to standard onychomycosis treatment with topical agents as well as with oral terbinafine and itraconazole. Objective: The aim of ...
Makhlouf Mona - - 2012
Abstract Objective: The aim of this split-mouth, double blinded, short-term, controlled clinical trial was to study the effect of low-level laser therapy (LLLT) as an adjunct to scaling and root planing (SRP) for treatment of chronic periodontitis. Background data: LLLT is reported to improve the outcome of traditional SRP, but ...
Connick Peter P Department of Clinical Neurosciences, University of Cambridge, Cambridge, - - 2012
More than half of patients with multiple sclerosis have progressive disease characterised by accumulating disability. The absence of treatments for progressive multiple sclerosis represents a major unmet clinical need. On the basis of evidence that mesenchymal stem cells have a beneficial effect in acute and chronic animal models of multiple ...
Carey Brenda - - 2012
Aim This Phase I clinical trial explored the viability of webcam Internet delivery of the Camperdown Program for adolescents who stutter. Methods and Procedures Participants were three adolescents aged 13, 15, and 16 years with moderate-severe stuttering. Each was treated with the Camperdown Program delivered by webcam with no clinic ...
Rovin Brad H BH Ohio State University, Columbus, OH 43210, USA. - - 2012
To evaluate the efficacy and safety of rituximab in a randomized, double-blind, placebo-controlled phase III trial in patients with lupus nephritis treated concomitantly with mycophenolate mofetil (MMF) and corticosteroids. Patients (n = 144) with class III or class IV lupus nephritis were randomized 1:1 to receive rituximab (1,000 mg) or ...
Serra-Guillén Carlos - - 2012
BACKGROUND: Photodynamic therapy (PDT) and imiquimod are the treatments of choice for actinic keratosis (AK). As they have different mechanisms of action, it seems reasonable to assume that applying both treatments sequentially would be efficacious. OBJECTIVES: We sought to determine which of these therapeutic modalities provides a better clinical and ...
Igic M - - 2012
The purpose of this study was to determine the level of gingival inflammation and the prevalence of periodontopathogenic microorganisms in adolescents with chronic gingivitis, as well as to compare the effectiveness of two approaches in gingivitis treatment-basic therapy alone and basic therapy + adjunctive low-level laser therapy (LLLT). After periodontal ...
Kay Alastair T - - 2012
OBJECTIVE: To describe the characteristics of osteomyelitis lesions of the patella and to report short- and long-term outcome after treatment in 8 foals. STUDY DESIGN: Retrospective case series. ANIMALS: Foals (n = 8). METHODS: Medical records (2003-2007) and radiographs of foals that had osteomyelitis of the patella were reviewed. Inclusion ...
Lee Sang-Hak - - 2012
OBJECTIVE: The aim of this study is to compare the non-lipid effects of rosuvastatin-fenofibrate combination therapy with rosuvastatin monotherapy in high-risk Asian patients with mixed hyperlipidemia. METHODS: A total of 236 patients were initially screened. After six weeks of diet and life style changes, 180 of these patients were randomly ...
Kwon Y-D - - 2012
To review the effect of teriparatide as an adjunctive modality for bisphosphonate-related osteonecrosis of the jaws (BRONJ), we describe a series of cases of teriparatide therapy for the treatment of BRONJ and serial changes of serum osteoclacin (s-OC) and serum C-terminal telopeptide cross-link of type I collagen (s-CTX). INTRODUCTION: Management ...
Simini Bruno - - 2012
To the Editor: In the article by Granger et al. describing the results of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) study (Sept. 15 issue),(1) it was disappointing that patients with atrial fibrillation who were treated with warfarin had an international normalized ratio ...
- - 2012
To the Editor: In the article by Granger et al. describing the results of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) study (Sept. 15 issue),(1) it was disappointing that patients with atrial fibrillation who were treated with warfarin had an international normalized ratio ...
Zorn Kevin C - - 2012
Study Type - RCT (randomized trial) Level of Evidence 2b What's known on the subject? and What does the study add? In a previous randomized controlled trial, barbed polyglyconate suture for vesico-urethral anastomosis was associated with more frequent cystogram leaks, longer mean catheterization times and greater suture costs per case. In ...
Vassiliou Vassilios S - - 2012
To the Editor: In the article by Granger et al. describing the results of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) study (Sept. 15 issue),(1) it was disappointing that patients with atrial fibrillation who were treated with warfarin had an international normalized ratio ...
Mateen F J - - 2012
Background and purpose:  There are few clinical studies on the attempted treatments and outcomes in patients with Susac syndrome (SS) (retinocochleocerebral vasculopathy). Methods:  A retrospective review was performed of all patients presenting with SS at the Mayo Clinic in Rochester, Minnesota, USA (1 January 1998-1 October 2011). Results:  There were ...
Okazaki Shunichiro - - 2012
Aim of the study is to determine the relationship between liver function and the incidence of ONF after steroid therapy in AID patients. The present study investigated 58 AID patients who had received high-dose systemic steroid therapy to determine whether a correlation exists between parameters of hepatic function and steroid-induced ...
Hirst Claire L - - 2012
Background: Relapse is a characteristic clinical feature of multiple sclerosis (MS) and is commonly employed as a measure of efficacy following therapeutic intervention. However, less is known about the temporal evolution of subsequent disability or factors predicting recovery.Objectives: The objective of this study was to assess the pattern of recovery ...
Chen YongFa - - 2012
The aim of the current study was to compare the effectiveness of adefovir dipivoxil (ADV) monotherapy with that of combination ADV and lamivudine (LAM) therapy in the treatment of LAM-resistant chronic hepatitis B (CHB). Publications on the effectiveness of ADV monotherapy versus the combination of ADV and LAM therapy for ...
Ricci Federico - - 2012
PURPOSE: We performed a prospective noncomparative study to report the results of reduced fluence photodynamic therapy (PDT) combined with intravitreal ranibizumab in patients with polypoidal choroidal vasculopathy with active exudation and hemorrhage. METHODS: Seventeen polypoidal choroidal vasculopathy eyes were treated, and follow-up for all patients was 12 months. Photodynamic therapy ...
Shami Paul J - - 2012
With the development of tyrosine kinase inhibitors (TKIs), the management and outlook for patients with chronic myelogenous leukemia (CML) have completely changed over the past 10 years. Imatinib was the first TKI approved to treat CML in the chronic phase. After their initial approval as second-line agents, dasatinib and nilotinib ...
Dai Wei-Qi - - 2012
This study aimed to compare the 7d triple therapy with 3d and 5d triple therapies, to observe the effect of eradicating Helicobacter pylori (Hp) on treating duodenal ulcers. One hundred and sixteen patients who were confirmed duodenal ulcer active period and Hp positive were enrolled in the study. All the ...
Utrilla-Rodríguez Elia María - - 2012
: To evaluate the efficacy of a modified Copenhagen physical therapy method in reducing surgery rates for congenital idiopathic clubfoot. : This research is a retrospective descriptive study of 82 patients (123 clubfeet). All patients were younger than 2 months at the beginning of the treatment and were initially evaluated ...
Akaishi Satoshi - - 2012
Pathological cutaneous scars such as keloids and hypertrophic scars (HSs) are characterized by a diffuse redness that is caused by the overgrowth of capillary vessels due to chronic inflammation. Our group has been using long-pulsed, 1064-nm Nd:YAG laser in noncontact mode with low fluence and a submillisecond pulse duration to ...
Chu Alice - - 2012
The Ponseti method of clubfoot correction is now widely practiced worldwide. Initial correction rates are nearly 100%, but subsequent relapses may occur in up to one-third of patients. Very little has been written by anyone other than Dr Ponseti about the characterization and treatment of recurrent clubfoot deformity following use ...
Gupta Divya - - 2012
Depigmentation therapy in vitiligo is an option in those with extensive vitiligo who have failed to respond to medical therapy and have obvious cosmetic disfigurement due to intervening patchy pigmented areas. Various aspects of this therapy such as the cost, treatment time, course, permanency of depigmentation, side effects, and the ...
Batra Ruchika - - 2012
We sought to evaluate the efficacy of topical 3% diclofenac gel in the management of periocular actinic keratosis. Four consecutive patients with periocular actinic keratosis who were treated with topical 3% diclofenac gel twice daily for up to 4 months were included in the study. Patients were reviewed at 1 ...
Sugawara Junji - - 2012
Despite the known influence of early treatment on the facial appearance of growing patients with skeletal Class III malocclusion, few comparative reports on the long-term effects of different treatment regimens (1-phase vs 2-phase treatment) have been published. Uncertainty remains regarding the effects of early intervention on jaw growth and its ...
Pietrzak Radosław - - 2012
Background and aim: To analyse selected electrocardiographic (ECG) parameters in children after correction of tetralogy of Fallot (TOF). Methods: The study group consisted of 65 patients with surgically corrected TOF aged 6 to 18 years, and the time since surgical correction ranged from 6 to 18 years. The patients were ...
Bogner Johannes R - - 2012
Non-nucleoside antiretroviral combination therapy is the standard of care with a robust virologic efficacy and a good safety profile. One of the most frequently used non-nucleosides, nevirapine (NVP), has been available as a every 12 h, immediate-release (IR) tablet since 1996. In order to enhance convenience and adherence, a new ...
Hassan Megahed M - - 2012
To evaluate the long-term efficacy of arytenoid adduction (AA) combined with ansa cervicalis-recurrent laryngeal nerve anastomosis (ACN-RLN) in the treatment of unilateral vocal fold paralysis. Retrospective review of clinical records. Institutional practice. Nine patients with severe paralytic dysphonia with large glottal gap were included. Voice outcome was followed up over ...
Oida Takatsugu - - 2012
Background/Aims: The management of peptic ulcers has dramatically changed and the incidence of elective surgery for gastroduodenal peptic ulcers has markedly decreased; hence, the incidence of emergency surgery for perforated peptic ulcers has slightly increased. In select cases, conservative therapy can be used as an alternative for treating perforated gastroduodenal ...
Aydogan Kenan - - 2012
Background  Chronic ordinary urticaria (COU) can severely reduce quality of life and be difficult to control. Ultraviolet (UV) A and UVB phototherapy has been reported to decrease the release of histamine from either mast cells and/or basophils. Previous small studies have suggested that UVB phototherapy is a good alternative treatment ...
Haag-Weber Marianne - - 2012
Background: HX575 is a biosimilar version of epoetin-α that is approved for the treatment of anemia associated with chronic kidney disease (CKD) using the intravenous route of administration. Here we report data from a study of anemic pre-dialysis patients to assess the safety, immunogenicity and efficacy of subcutaneous (s.c.) administration ...
Yagci Ayse - - 2012
To report the long-term results of tarsal margin rotation with extended posterior lamellae advancement in the management of cicatricial entropion, trichiasis, and accompanying misdirected metaplastic lashes of the upper eyelid due to trachoma. Tarsal margin rotation and extended advancement of posterior lamellae were performed in 27 eyelids of 15 consecutive ...
Froissart Antoine - - 2012
To assess the efficacy and safety of rituximab in adults responding poorly to standard treatment for severe autoimmune thrombotic thrombocytopenic purpura. Open-label prospective study. Outcomes in the survivors were compared to those of 53 historical survivors who were given therapeutic plasma exchange alone or with vincristine. Hospitals belonging to the ...
Stefanou Amalia - - 2012
We designed a prospective, randomized study to evaluate the effects of iontophoresis delivery of dexamethasone versus corticosteroid injection therapy on patient outcomes. We randomized 82 patients to 10 mg dexamethasone via iontophoresis using a self-contained patch with a 24-hour battery; 10 mg dexamethasone injection; or 10 mg triamcinolone injection. All ...
Shea Paul F - - 2012
To evaluate the hearing changes and quality-of-life outcomes of 393 cases of streptomycin/dexamethasone inner ear perfusion performed by the primary author on 312 ears of 299 patients with Meniere's disease between July 2002 and May 2010. Retrospective chart review. Objective arm: A database was used to compile pretreatment and post-treatment ...
Ferenci P - - 2012
Summary.  The rapidity of viral disappearance on antiviral treatment of chronic hepatitis C with peginterferon/ribavirin correlates with the cure rate. The earlier the virus becomes undetectable, the higher are the response rates. This observation is the basis of response-guided therapy. Viral clearance within the first 4 weeks of treatment is ...
Miyamoto Hidenori - - 2012
Background/Aims: Aluminum potassium sulfate and tannic acid (ALTA) is a new sclerosing therapy for internal hemorrhoids. This injection therapy is a four-step direct injection sclerosing procedure intended to shrink and harden internal hemorrhoids to eliminate hemorrhoidal prolapse and bleeding. The aim of this study was to assess the short term ...
Hodgkinson J A - - 2012
Although there has been growing concordance over what constitutes best practice in recent guidelines for treatment of atrial fibrillation (AF), notably regarding anticoagulant use, it remains unclear whether patients are being treated accordingly. The aims of this study were to explore the pattern of treatment pathways - i.e. how patients ...
Tong Guang-Dong - - 2012
To observe the efficacy of ursodeoxycholic acid (UDCA) combined with Tongdan: Decoction () on immunological indices and histopathological changes in patients with primary biliary cirrhosis (PBC) of IIor III histological stage. Sixty PBC patients were assigned randomly and equally: to the control group treated with UDCA alone and the treatment ...
Pessôa Mario G - - 2012
A large number of patients with chronic hepatitis C have not been cured with interferon-based therapy. Therefore, we evaluated the efficacy of amantadine combined with the standard of care(pegylated interferon plus ribavirin) in patients who had not responded to or had relapsed after ≥ 24 weeks of treatment with conventional ...
Lim Young-Suk - - 2012
The combination of entecavir, a nucleoside analogue, and adefovir, a nucleotide analogue, would be a promising salvage treatment for chronic hepatitis B (CHB) patients who fail nucleoside/nucleotide analogue (NA) regimens. A total of 89 CHB patients who had failed NA regimens and were treated with entecavir plus adefovir combination for ...
Avila Marcos P - - 2012
To evaluate the long-term safety and visual acuity outcomes associated with epimacular strontium 90 brachytherapy combined with intravitreal bevacizumab for the treatment of subfoveal choroidal neovascularization because of age-related macular degeneration. Thirty-four treatment-naive patients with predominantly classic, minimally classic, and occult subfoveal choroidal neovascularization lesions participated in this prospective, 2-year, ...
Veritti Daniele - - 2012
To investigate the effect of the combination of photodynamic therapy with verteporfin and subconjunctival bevacizumab and triamcinolone acetonide on corneal neovascularization secondary to corneal graft failure. A patient with extensive deep and superficial corneal neovascularization underwent same day triple therapy with subconjunctival bevacizumab (1.25 mg), subconjunctival triamcinolone acetonide (40 mg), ...
Laws P M - - 2012
There are limited data on the use of ustekinumab outside of clinical trials. To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 dermatology centres in the U.K. and Ireland. A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab. Baseline Psoriasis Area ...
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