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Saito Tsukasa T Division of Cardiovascular, Respiratory and Neurology, Department of Internal Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan, - - 2014
Segmental craniocervical dystonia is characterized by blephalospasm and oromandibular dystonia and is also called Meige syndrome. The current treatment strategy including botulinum toxin (BTX) injections has not yet attained an acceptable level. We describe a long-term favorable response of a novel combination therapy with aripiprazole (ARP), trihexyphenidyl (THP), and BTX ...
Yildiz B S BS Department of Internal Medicine, Dr Lutfi Kirdar Kartal Educational and Research Hospital, Istanbul, Turkey. - - 2014
In case of coronary stenting in patients taking long-term oral anticoagulants (OAC), addition of both aspirin and clopidogrel in the drug regimen (so-called triple antiplatelet therapy) is recommended. However such triple therapy increases the risk of serious bleeding events. Comparative data on the efficacy and safety of the triple therapy ...
Morgia Giuseppe G Department of Urology, University of Catania, Catania, - - 2014
Phytotherapy has been used to treat patients with lower urinary tract symptoms (LUTS). We evaluated the efficacy and tolerability of combination therapy between Serenoa Repens (SeR), Lycopene (Ly), and Selenium (Se) + tamsulosin versus single therapies. PROCOMB trial (ISRCTN78639965) was a randomized double-blinded, double-dummy multicenter study of 225 patients between 55 and ...
Vlachaki Efthymia E Hematological Laboratory, Second Department of Internal Medicine, General Hospital Hippokrateon, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
Background/Aim: Thrombopoietin receptor agonists (romiplostim and eltrombopag) have recently been licensed for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenia (ITP) with an insufficient response to corticosteroids, immunoglobulins or splenectomy. In the present case series, we present 4 nonresponding patients with chronic ITP who achieved maintenance of complete ...
Das-Gupta Emma E Nottingham University Hospitals NHS Trust, Nottingham, - - 2014
Second-line therapy for corticosteroid-refractory or dependent acute graft-versus-host disease remains ill-defined, due to limited efficacy of drugs and evolving clinical trial endpoints. Six month freedom from treatment failure has been proposed as a novel clinical trial endpoint and is defined by the absence of death, malignancy relapse/progression, or addition of ...
Seitz Anna-Theresa - - 2014
Abstract Background and Objective: Q-switched laser treatments are considered the standard method for removing both regular and traumatic tattoos. Recently, the removal of tattoo ink using ablative fractional lasers has been reported. Ablative fractional CO2-laser and q-switched-ruby laser treatments were used in a split-face mode to compare the safety and ...
Sandborn W J WJ Division of Gastroenterology, University of California San Diego School of Medicine, La Jolla, CA, - - 2014
The efficacy and safety of certolizumab pegol (CZP) in moderate-to-severe Crohn's disease were demonstrated in two 26-week double-blind studies (PRECiSE 1 & 2). To report the safety and efficacy outcomes of long-term, CZP therapy from PRECiSE 3, in which patients received treatment up to 7 years treatment. Patients completing PRECiSE 1 ...
Cosma Dan I DI Department of Paediatric Orthopaedics, University of Medicine and Pharmacy 'Iuliu Haţieganu', Cluj-Napoca, - - 2014
Manipulation and casting according to the Ponseti method are the 'gold standard' for clubfoot treatment, and this method is endorsed by the American Association of Orthopaedic Surgeons. We conducted a retrospective study from January 2004 to December 2012 in our institution. All patients with idiopathic clubfoot were included, and a ...
Onol Fikret Fatih FF Ümraniye Training and Research Hospital, Clinic of Urology, Istanbul, Turkey. Electronic address: - - 2014
We aimed to compare long-term success of desmopressin lyophilisate (DESM-melt) and enuretic alarm (EA) in primary monosymptomatic nocturnal enuresis (PMNE), and to determine predictive factors for success. 142 children with PMNE were randomized to receive DESM-melt or EA treatment for 6 months. Treatment compliance and response were reviewed monthly in ...
Taudorf Elisabeth H EH Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, - - 2014
Non-ablative fractional laser-treatment is evolving for burn scars. The objective of this study was to evaluate clinical and histological long-term outcome of 1,540 nm fractional Erbium: Glass laser, targeting superficial, and deep components of mature burn scars. Side-by-side scar-areas were randomized to untreated control or three monthly non-ablative fractional laser-treatments using ...
Premchand Rajendra K RK Krishna Institute of Medical Sciences, Secunderabad, - - 2014
ANTHEM-HF evaluated a novel autonomic regulation therapy (ART) via either left or right vagus nerve stimulation (VNS) in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Sixty subjects (NYHA class II-III, LVEF≤40%, LVEDD≥50 mm and <80 mm) receiving optimal pharmacological therapy were randomized at 10 sites. VNS systems ...
Zhang Huabin F - - 2014
IntroductionThis study aimed to describe treatment changes (discontinuation, switching, and therapy add-on) following the initiation of a biologic or nonbiologic oral disease-modifying antirheumatic drugs (DMARDs) in psoriatic arthritis (PsA) patients.MethodsAdult patients with ¿2 PsA diagnoses from physician office visits, initiated on a biologic or non-biologic oral DMARD, were selected from ...
Keestra J A J JA Department of Oral Health Sciences, Periodontology, KU Leuven & University of Leuven, Leuven, Belgium; Department of Periodontology, University Hospitals Leuven, Leuven, - - 2014
The purpose of this meta-analysis is to evaluate the effectiveness of different systemic antibiotics in combination with scaling and root planing (SRP) when compared to SRP alone in patients with untreated chronic periodontitis. Although chronic periodontitis is mostly treated without adjunctive systemic antibiotics, some recent meta-analyses have shown clinical benefit ...
Rollan Antonio A Antonio Rollan, Pablo Cortés, Luisa Durán, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7650568, - - 2014
To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature. Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was ...
Marcellin Patrick P Service d'Hépatologie, INSERM-CRB3, Hôpital Beaujon, Clichy, France. Electronic address: - - 2014
This study investigated the antiviral efficacy and safety of telbivudine in combination with pegylated interferon (PegIFN) alpha-2a in chronic hepatitis B (CHB). This was a randomized, open-label, multicenter study, in treatment-naïve patients with HBeAg-positive CHB, comparing the efficacy and safety of telbivudine in combination with PegIFN alpha-2a with telbivudine monotherapy ...
Pisani Antonio A Nephrology, Department of Public Health, University Federico II, Naples, - - 2014
Proteinuria is the predominant risk factor for renal disease progression in Fabry disease (FD). When urine protein excretion is controlled to <0.50 g/24 h, the rate loss of glomerular filtration rate (GFR) is not significantly different from 0. However, enzyme replacement therapy (ERT) alone does not decrease proteinuria and it ...
McMillan Catherine C Division of Plastic and Reconstructive Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, - - 2014
To compare long-term outcomes and retreatment rates for patients with Dupuytren disease who underwent needle aponeurotomy (NA) combined with a series of triamcinolone acetonide injections or underwent NA alone as part of a prior randomized controlled trial. During this follow-up study, 44 of 47 participants in the original study were ...
Inui Takehiko T Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, 20 Shishioto, Akiu Yumoto, Taihaku-ku, Sendai-shi, Miyagi 982-0241, - - 2014
Background: Adrenocorticotropic hormone (ACTH) therapy is the first-line therapy for infantile spasms, and is effective for many other intractable epilepsies. While spasms may respond to ACTH for weeks, a substantial proportion of patients develop recurrent seizures over a yearly period. To maintain efficacy, we treated two children with intractable epilepsy ...
Neoh Sandra L SL Department of Endocrinology, Austin Health, Melbourne, VIC, Australia. - - 2014
To investigate the safety, tolerability and efficacy of combination phentermine and topiramate therapy for maintenance of weight loss. Retrospective audit of patients attending the Austin Health Weight Control Clinic who were dispensed phentermine-topiramate between 22 January 2010 and 16 July 2012 and after reaching a target weight by following a ...
Cheng Jun J Beijing Ditan Hospital, Capital Medical University, No. 8 East Jingshun Street, Beijing 100015, China. Electronic address: - - 2014
In mainland China, peginterferon (PEG-IFN) alfa-2b 1.0μg/kg/wk for 24 weeks is the approved treatment for HBeAg-positive chronic hepatitis B. This multicenter, randomized trial evaluated the safety and efficacy of regimens utilizing increased dose or treatment duration in treatment-naive Chinese patients with chronic hepatitis B. 670 HBeAg-positive patients from China, Malaysia, ...
Tvrdy Peter P Department of Oral and Maxillofacial Surgery, University Hospital Olomouc, Czech - - 2014
Arthrocentesis of the temporomandibular joint is a minimally invasive method of treatment located at the boundary between conservative and surgical therapy. It is usually performed on an out-patient basis under local anaesthesia. These days, arthrocentesis of the temporomandibular joint is used not only in cases of acute closed lock but ...
Gordon Jessica J Hospital for Special Surgery, New York, USA. - - 2014
We aimed to assess the long-term safety and tolerability of imatinib in diffuse cutaneous systemic sclerosis (dcSSc). In this open-label, single-arm, extension-phase clinical trial, patients continued imatinib for 24 months following 12 months of initial treatment. Seventeen patients enrolled. Forty of 92 adverse events (AE) and 0/6 serious (S) AE ...
Haro Josep M JM Parc Sanitari Sant Joan de Deu, CIBERSAM, Barcelona, Spain. Electronic address: - - 2014
This analysis aimed to examine the association between remission and quality of life (QOL) in schizophrenia. In post-hoc analyses of the 3-year, prospective, observational Schizophrenia Outpatients Health Outcomes (SOHO) study, we compared the QOL of patients who achieved symptomatic and clinical remission with those who did not, and the factors ...
Javois Alexander J AJ Advocate Children's Hospital, Oak Lawn, Illinois; University of Illinois Medical College, Chicago, Illinois. Electronic address: - - 2014
This report describes the immediate, 1-, and 5-year follow-up results of the U.S. Food and Drug Administration Continued Access clinical trial of the GORE HELEX Septal Occluder (W. L. Gore & Associates, Inc., Flagstaff, Arizona) for closure of secundum atrial septal defect. The trial was conducted between May 2003 and ...
Park So-Young SY Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, - - 2014
Korean red ginseng (KRG) has hypoglycemic, antioxidant, antithrombotic, and other beneficial effects in human. The present study evaluate the therapeutic effects of KRG on hearing recovery and glucocorticoid-induced hyperglycemia in patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing systemic steroid therapy. The patients were divided into 2 groups: the ...
McNaught Melinda K - - 2014
In 2001, the red imported fire ant (Solenopsis invicta Buren) was identified in Brisbane, Australia. An eradication program involving broadcast bait treatment with two insect growth regulators and a metabolic inhibitor began in September of that year and is currently ongoing. To gauge the impacts of these treatments on local ...
Yoon Jin A JA Department of Rehabilitation Medicine, Pusan National University School of Medicine, Busan, - - 2014
To evaluate the effectiveness of constraint-induced movement therapy (CIMT) and combined mirror therapy for inpatient rehabilitation of the patients with subacute stroke. Twenty-six patients with subacute stroke were enrolled and randomly divided into three groups: CIMT combined with mirror therapy group, CIMT only group, and control group. Two weeks of ...
Choi Jun Hwan JH Department of Rehabilitation Medicine, Jeju National University Hospital, Jeju, - - 2014
To investigate the effectiveness of commercial gaming-based virtual reality (VR) therapy on the recovery of paretic upper extremity in subacute stroke patients. Twenty patients with the first-onset subacute stroke were enrolled and randomly assigned to the case group (n=10) and the control group (n=10). Primary outcome was measured by the ...
Park Jong-Wan JW Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, - - 2014
To investigate the long-term effect of low-energy extracorporeal shock wave therapy (ESWT) for plantar fasciitis (PF) according to ultrasonography (US) findings. Thirty feet of 25 patients with clinical diagnosis of PF were enrolled and divided into two groups (Apparent-US and Uncertain-US) according to US findings, such as plantar fascia thickening ...
Parida Amrita A Postgraduate, Department of Pharmacology, Kasturba Medical College , Manipal, Manipal University, Karnataka, India - - 2014
Directly observed treatment short course (DOTS) and self-administered therapy (SAT) are the treatment options available for tuberculosis (TB). Studies conducted worldwide have shown difference in treatment outcome with these two treatment modalities. The study was undertaken to compare treatment outcome of DOTS and SAT in patients of pulmonary TB taking ...
Lazzaro Marc A MA Department of Neurology, Medical College of Wisconsin/Froedtert Hospital, Milwaukee, Wis., USA ; Department of Neurosurgery, Medical College of Wisconsin/Froedtert Hospital, Milwaukee, Wis., - - 2014
In the Solitaire With the Intention For Thrombectomy (SWIFT) trial, rescue therapy was used when the Solitaire or Merci device was unable to restore vessel patency. Markers for nonrecanalization in acute stroke have been reported for intravenous tissue plasminogen activator; however, similar predictors are not known for endovascular therapy. We ...
Golfam Farzaneh F Department of Surgery, Mostafa Khomeini Hospital, Shahed University, Tehran, IR - - 2014
Medical sphincterotomy has gained popularity as a treatment for anal fissure. Calcium channel blockers in topical forms could also be appropriate with low adverse effects. This was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. A prospective randomized controlled trial ...
Jayakody Himali H Division of Child Neurology, Department of Pediatrics, University of Iowa Children's Hospital, 200, Hawkins Drive, Iowa City, Iowa 52242. Electronic address: - - 2014
Optic neuritis is an important pediatric disorder causing visual impairment. Because of the absence of pediatric-specific studies, data extrapolated from the adult-based optic neuritis treatment trial are used to guide management of pediatric patients. Recent literature promotes a prolonged course of oral steroids to prevent relapses. However, there are no ...
- - 2014
When severe gout with tophi persists despite treatment with allopurinol, a xanthine oxidase inhibitor, the hypouricaemic drug of choice is probenecid, a uricosuric agent, in the absence of a better alternative. Pegloticase is a pegylated recombinant uricase. This enzyme catabolises uric acid into allantoin, a water-soluble substance that is excreted ...
de Molon Rafael Scaf RS Department of Diagnosis and Surgery, School of Dentistry at Araraquara, University of Estadual Paulista, Araraquara, São Paulo, - - 2014
Extensive intraosseous lesions represent a clinical challenge for the periodontist. Sites with bone defects have been shown to be at higher risk of periodontitis progression in patients who had not received periodontal therapy. Thus, the aim of this case report was to describe a novel approach for the treatment of ...
Nagalakshmi S S Department of Orthodontics, Vivekananda Dental College for Women, Tiruchengode, Namakkal, Tamil Nadu, - - 2014
The aim of our study is to evaluate the changes in quality of life among patients treated for maxillary midline diastema by fixed orthodontic appliances. This prospective longitudinal study consists of 40 patients of age group 20-30 years who underwent orthodontic correction of midline diastema. The patient's quality of life ...
Lü Peng-Hua PH Department of Radiology, First Hospital Affiliated to Nanjing Medical University, Nanjing, China Department of Interventional Radiology, Northern Jiangsu People's Hospital, Yangzhou, - - 2014
Spontaneous isolated superior mesenteric artery dissection (ISMAD) is exceedingly rare. The therapeutic options range from observation to medical treatment to surgery or endovascular repair. We present our experience of the clinical management of ISMADs. Sixteen patients with ISMAD from January 2008 to July 2012 were retrospectively analyzed. The decision to ...
Shui Shao-Feng SF Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, - - 2014
This study aimed to investigate the efficacy and safety of balloon dilatation and thrombus extraction for the treatment of cerebral venous sinus thrombosis (CVST). Twenty-six cases of digital subtraction angiography-confirmed CVST were treated with balloon dilatation and thrombus extraction. Active treatment of primary disease was carried out after cerebral venous ...
Bell Simon N SN Department of Surgery, Melbourne Shoulder and Elbow Centre, Monash University, Melbourne, - - 2014
It is agreed that it is important to anatomically reproduce the proximal humeral anatomy when performing a prosthetic shoulder replacement. This can be difficult with a long stemmed prosthesis, in particular if there is little relationship of the metaphysis to the humeral shaft. The 'short stem' prosthesis can deal with ...
Krasny Marta - - 2014
Cardiovascular conditions, apart from neoplastic diseases, remain the major cause of death in developed countries; therefore, the number of patients receiving oral anticoagulants is constantly increasing. Anticoagulant therapy considerably reduced mortality in patients with history of myocardial infarction among others. Although many interventions may be performed without withdrawal of the ...
Souza Thiago Ferreira TF Gastrointestinal Endoscopy Unit, Departmentof Gastroenterology, University of São Paulo. São Paulo, - - 2014
Background: Barrett's esophagus (BE) is the main risk factor for esophageal adenocarcinoma. Its therapeutic approach is controversial and surgical treatment in the presence of high-grade intraepithelial neoplasia may be indicated. Endoscopic approach is an alternative with lower mortality and morbidity rates and favorable results. Objective: To define the best option, ...
Sharwani A A Department of Oral and Maxillofacial Surgery, Eastman Dental Institute for Oral Healthcare Sciences, London, - - 2014
Photodynamic therapy (PDT) utilizing aminolevulinic acid (ALA) as a photosensitiser has been used to ablate premalignant/malignant skin conditions including superficial basal cell carcinoma (BCC) with acceptable cosmetic outcome. Clinicians continue however to face difficulties in determining the exact dose that is sufficient to achieve a complete healing from the condition ...
Bogaz Eduardo Amaro EA Department of Otorhinolaryngology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, - - 2014
Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) is defined when a loss of at least 30 dB occurs in over 3 continuous frequencies, in up to 72 hours, of which etiology is not established, despite adequate investigation. Different types of treatment regimens have been proposed, but only glucocorticoids have shown some ...
Qiu Yongbin Y Shandon Medical University, Shandong, - - 2014
To investigate the effect of spa adjuvant therapy on diabetic lower extremity arterial disease (LEAD). 128 patients with type II diabetes were separated into three groups according to the degree of lower extremity vascular stenosis. Patients within each group were then randomly divided to receive no treatment (control) or spa ...
Capistrano Anderson - - 2014
Orthodontics, just as any other science, has undergone advances in technology that aim at improving treatment efficacy with a view to reducing treatment time, providing patients with comfort, and achieving the expected, yet hardly attained long-term stability. The current advances in orthodontic technology seem to represent a period of transition ...
Pardhan Amyn - - 2014
To further resolve the clinical equipoise on the choice of chemical sphincterotomy agent for early symptomatic relief of anal fissure by comparing the effectiveness of 2% Diltiazem gel with 0.2% Glyceryl TriNitrate. The randomized clinical trial was conducted at Aga Khan University Hospital, Karachi, from February 1, to July 30, ...
Baspinar Osman - - 2014
To determine in paediatric patients with atrial septal defects whether differences in P wave dispersion occurred with transcatheter closures using the Amplatzer septal occluder. A total of 31 children who had undergone transcathater closures were evaluated. P maximum, P minimum, and P dispersion were measured with 12-lead surface electrocardiography, before ...
Coaccioli Stefano S General Medical Clinic and Medical Therapy, Rheumatology and Medical Therapy of the Pain, University of Perugia, "Polo di Terni", "AO Santa Maria" of Terni, Terni, - - 2014
Since low adherence to a long-term therapy results in a poor clinical outcome and significantly increases healthcare costs, adherence to the treatment of chronic disorders is an issue of great interest. This is particularly true of the treatment of osteoporosis (OP). Adherence to the osteoporosis therapy in patients treated with ...
Santner Wolfram W Department of Radiology, Kantonsspital Baden, - - 2014
Recombinant human erythropoietin (rhuEPO) has received considerable attention because of its neuroprotective properties. It has recently been reported that rhuEPO increases frataxin levels in combination with clinical improvement in rhuEPO treated patients with Friedreich ataxia (FRDA). To determine possible therapy dependent intracranial volume changes after treatment with rhuEPO using voxel-based ...
Mlachkova Antoaneta M - - 2014
Chronic periodontitis is defined as an inflammatory disease of the supporting tissues of teeth caused by microorganisms in the dental biofilm, resulting in progressive destruction of the periodontal ligament and alveolar bone with pocket formation and gingival recession. Treatment of chronic periodontitis aims at arresting the inflammation and stopping the ...
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