Search Results
Results 301 - 350 of 2577
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Tivers M S - - 2011
A variety of surgical treatments and medical therapies are recommended for dogs with extrahepatic congenital portosystemic shunts (CPSS). The objective of this review was to assess the evidence base for the management of extrahepatic CPSS in dogs. An online bibliographic search was performed in November 2010 to identify articles relating ...
Tkacz Joseph J Health Analytics, LLC, 9200 Rumsey Road, Columbia, MD 21045, USA. - - 2012
Opioid dependence (OD), often characterized as a chronic relapsing disorder, affects millions of people worldwide. The purpose of this study was to examine the effect of compliance with buprenorphine on reducing relapse among a sample of patients in treatment for OD. Patients new to buprenorphine (N = 703) completed the Addiction ...
Dooley Mary Anne - - 2011
Maintenance therapy, often with azathioprine or mycophenolate mofetil, is required to consolidate remission and prevent relapse after the initial control of lupus nephritis. We carried out a 36-month, randomized, double-blind, double-dummy, phase 3 study comparing oral mycophenolate mofetil (2 g per day) and oral azathioprine (2 mg per kilogram of ...
Shah Dharmesh - - 2011
Background:  Octreotide, a somatostatin analogue, is used for the management of patients with refractory chylothorax although its safety and efficacy in neonates has not been evaluated in controlled clinical trials. We present one of the largest case series about the use of octreotide in congenital idiopathic chylothorax. Methods:  Six cases ...
Behzad M - - 2011
Background:  Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune bullous disorder which is characterized by blisters and erosions of the skin and mucous membranes. A frequently applied first-line therapy of PV consists of systemic corticosteroids (CS) combined with immunosuppressive agents. In refractory cases, novel therapeutic strategies such as immunoadsorption (IA) ...
Al Bakri Ayman - - 2011
PURPOSE: While there are a number of studies documenting a positive effect of varicocelectomy on semen parameters, the length of time required following varicocelectomy for semen quality to improve is not well established. Therefore, in this study we identified the changes with time in semen parameters after varicocelectomy. MATERIALS AND ...
Mazzola Clarisse R - - 2011
Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen deprivation therapy significantly reduces erectile ...
Ayala Marcelo M Department of Glaucoma, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden. - - 2012
Reducing intraocular pressure (IOP) seems to be the only treatment that slows progression in glaucoma. The IOP can be decreased by pharmaceutical treatment, laser [selective laser trabeculoplasty (SLT)] treatment, or surgery. Prostaglandin analogues have been postulated to share action mechanisms with SLT and to possibly diminish the effects of SLT ...
Hedrich C M - - 2011
Systemic onset juvenile idiopathic arthritis (SoJIA) is a rare inflammatory disorder. It can result in disease and treatment-related disability. SoJIA is characterized by remitting fevers, evanescent rash, generalized lymphadenopathy, hepatomegaly/splenomegaly, and/or serositis. Non-responsiveness to standard therapy with corticosteroids and disease modifying antirheumatic drugs is not uncommon. IL-1β has been shown ...
Schaefer Betti - - 2011
BACKGROUND: Cholestatic pruritus may severely compromise quality of life. The Molecular Adsorbents Recirculating System (MARS) allows removal of pruritogenic substances without exposure to foreign proteins. Pediatric data, however, are scant. METHODS: We retrospectively analyzed the efficacy of MARS in three boys with severe cholestatic pruritus. They received a total of ...
Ha Minghao - - 2012
Adefovir is usually applied for therapy of chronic hepatitis B (CHB), but its effectiveness after cessation is still unknown. This study was to evaluate the effectiveness of adefovir treatment with strict cessation criteria in hepatitis B e antigen (HBeAg)-negative patients and to identify potentially important factors. One hundred forty-five HBeAg-negative ...
Chuan-Xing Li - - 2011
The purpose of this study is to analyze the safety and clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with portal vein stent and ¹²⁵I implantation for the treatment of portal vein tumor thrombus (PVTT) in hepatocellular carcinoma. Fifty-six patients from our department diagnosed with advanced hepatocellular carcinoma with PVTT ...
Schulman Sam S McMaster University, Thrombosis and Atherosclerosis Research Institute, and Ontario Clinical Oncology Group, Hamilton, Ontario, Canada. - - 2011
Guidelines recommend that patients receiving warfarin undergo international normalized ratio (INR) monitoring every 4 weeks. To investigate whether assessment of warfarin dosing every 12 weeks is as safe as assessment every 4 weeks. Noninferiority randomized trial. The randomization schedule (in a 1:1 ratio) was computer-generated, and allocation was concealed until ...
Kang Diana C - - 2011
PURPOSE: We critically assessed the methodological and reporting quality of published studies of ablative techniques for small renal masses. MATERIALS AND METHODS: We performed a systematic PubMed® and EMBASE® literature search from January 1966 to March 2010 to identify all full text, original research publications on ablative therapy for renal ...
McBeth John J Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, England. - - 2012
The clinical impact of telephone-delivered cognitive behavioral therapy (TCBT), exercise, or a combined intervention in primary care patients with chronic widespread pain (CWP) is unclear. A total of 442 patients with CWP (meeting the American College of Rheumatology criteria) were randomized to receive 6 months of TCBT, graded exercise, combined ...
Gupta Sumit - - 2011
BACKGROUND: Cure rates in paediatric acute myeloid leukaemia in low-income countries lag behind those in high-income countries, in part secondary to higher rates of treatment-related mortality. Patterns of treatment-related mortality are likely to differ between low and high-income centres. Understanding low-income setting patterns is necessary before effective interventions aimed at ...
Blizzard Robert M - - 2011
The first human to receive GH therapy was in 1956; it was of bovine origin and was given for 3 wk for metabolic balance studies revealing no effects. By 1958, three separate laboratories utilizing different extraction methods retrieved hGH from human pituitaries, purified it and used for clinical investigation. By ...
Begna Kebede H - - 2012
Ninety-four Mayo Clinic patients with myelofibrosis (MF) participated in two consecutive clinical trials of pomalidomide (0.5-3.5 mg/day), with or without prednisone. Overall anemia response was 27% and increased to 53% in JAK2V617F-positive patients with <10 cm palpable splenomegaly and <5% circulating blasts; response rate was 0% in mutation-negative patients with ...
Ruiz Salas V - - 2012
To evaluate the efficacy of ustekinumab in a series of patients with moderate to severe psoriasis treated according to the European Medicines Agency (EMA) label and to identify factors such as dose, baseline PASI or previous treatment potentially related to therapeutic outcome. Retrospective review of the clinical records from 36 ...
Landy Stephen H - - 2011
Objective.- The objective of this study is to investigate migraines, both longitudinally and cross-sectionally, to understand the impact that time of treatment has on migraine duration and the patients' return to daily functioning. Background.- Several studies have explored the relationship between migraine treatment and its impact on migraine duration; however, ...
White William B - - 2011
J Clin Hypertens (Greenwich). 2011;13:910-916. ©2011 Wiley Periodicals, Inc. Anti-inflammatory and pain therapies have been associated with blood pressure (BP) destabilization. Hence, the effects on BP of sumatriptan/naproxen sodium in fixed-dose combination, sumatriptan 85 mg, and naproxen sodium 500 mg administered intermittently for the acute treatment of migraine attacks were assessed. Patients ...
Cameron Sharon T - - 2011
BACKGROUND: Subcutaneous depo-medroxyprogesterone acetate (DMPA-SC) offers the possibility of self-administration. STUDY DESIGN: This is a pilot study of self-administration of DMPA-SC. Existing users of the intramuscular preparation (DMPA-IM) who wished to self-inject (n=64) were taught self-administration using DMPA-SC. The main outcome was the continuation rate of the method at 12 ...
Saito Masaaki - - 2012
To clarify the efficacy of combined therapy with intravitreal ranibizumab injections and photodynamic therapy (PDT) in patients with symptomatic retinal angiomatous proliferation. Retrospective, interventional, consecutive case series. We retrospectively reviewed 20 treatment-naïve eyes of 16 patients (8 men, 8 women; age range, 79 to 92 years; mean age, 84.8 years) ...
Yamada Norikazu - - 2011
Untreated acute pulmonary thromboembolism (APTE) is associated with high mortality, which is reduced by prompt treatment. Anticoagulation is fundamental in the treatment of APTE and should be initiated from suspicion. The efficacy and safety of novel anticoagulant drugs, such as oral anti-Xa and anti-IIa inhibitors, are topics in the treatment ...
Salvarani Carlo - - 2011
Objective. Treatment of large-vessel vasculitis (LVV) remains challenging. Patients usually respond to glucocorticoid (GC) therapy, but often relapse on tapering of the GC dose or after GC withdrawal. In addition, GCs are fraught with numerous adverse events. The aim of this study was to assess the efficacy and safety of ...
Martinelli V - - 2011
To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics. We performed a multicenter retrospective cohort study of patients treated with MTX in MS centers under the Italian national health care system between 1998 and 2008. Demographic, disease, ...
Fujioka Toshio - - 2012
In recent years in Japan, the rate of clarithromycin (CAM) resistance in Helicobacter pylori has risen to around 30%, and the eradication rate with triple therapy [proton pump inhibitor + amoxicillin (AMPC) + CAM] has been trending downward to around 70%. In 2007, rabeprazole (RPZ)-based triple therapy (RPZ + AMPC ...
Alehan Dursun - - 2011
BACKGROUND: We performed a retrospective analysis of patients with pulmonary arterial hypertension receiving inhaled iloprost in a single centre to evaluate long-term tolerability, safety, and efficacy of chronic inhaled iloprost therapy in children. METHODS: A total of 20 patients with either idiopathic or associated pulmonary arterial hypertension were treated with ...
Kemper Markus J - - 2011
BACKGROUND: In patients with refractory steroid-sensitive nephrotic syndrome (SSNS), treatment with rituximab has shown encouraging results; however, long-term follow-up data are not available.METHODS: We performed a retrospective analysis of 37 patients (25 boys) with steroid-dependent nephrotic syndrome who were treated with rituximab (375 mg/m(2) given weekly for one to four ...
Broussard Karen Chen - - 2011
BACKGROUND: Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory disorder of unknown origin characterized by pustules, erosions, and crusting in areas of alopecia that tend to be atrophic, actinically damaged, or both. The most common treatments reported include antibiotics and topical anti-inflammatories, which can be ineffective. In the ...
Mauskopf Josephine A - - 2011
Abstract Objective: Decision-makers in the US may be interested in the applicability to their populations of cost-effectiveness results generated from clinical trial populations. Methods: An economic model estimating the cost-effectiveness of prasugrel plus aspirin relative to clopidogrel plus aspirin for patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention ...
von Renteln Daniel - - 2012
Endoscopic balloon dilatation and laparoscopic myotomy are established treatments for achalasia. Recently, a new endoscopic technique for complete myotomy was described. Herein, we report the results of the first prospective trial of peroral endoscopic myotomy (POEM) in Europe. POEM was performed under general anesthesia in 16 patients (male:female (12:4), mean ...
Kajbafzadeh Abdolmohammad - - 2011
Purpose:To present the results of our experience with combined endoureterotomy and endoscopic injection of dextranomer/hyaluronic acid (Deflux?) for the treatment of primary obstructive megaureter (PORM). Materials and methods:18 children (12 female, 6 male; mean age of 14 months) with 20 PORM units underwent concomitant endoureterotomy and endoscopic subureteric Deflux? injection. ...
Velat Gregory J - - 2011
OBJECTIVE: Cerebral venous sinus thrombosis (CVST) is a rare cause of stroke. A 21 year-old female presented to our institution in a rapidly deteriorating neurological state following failed systemic heparin therapy for treatment of superior sagittal sinus (SSS) thrombosis. METHODS: The patient underwent emergent mechanical thrombectomy of the thrombosed SSS ...
Kemta Lekpa Fernando - - 2011
BACKGROUND: There is no standardized therapeutic protocol for relapsing polychondritis (RP). Emergence of biologics holds much hope in the management of this connective tissue disease. OBJECTIVES: To evaluate the efficacy and safety of biologics in patients with active RP. METHODS: A systematic review of the literature using PubMed was performed ...
Moffatt C J - - 2011
Objective:  To investigate efficacy and safety of the 3M™Coban™ 2 compression system (Coban 2 system) with different application frequencies in comparison to short-stretch bandaging Methods:  A multi-centre, randomised, prospective study was performed with 82 patients suffering from arm or leg lymphoedema stage II or late stage II. Patients were allocated to ...
Marin David - - 2011
PURPOSEWe studied BCR-ABL1 transcript levels in patients with chronic myeloid leukemia in chronic phase (CML-CP) at 3, 6, and 12 months after starting imatinib to identify molecular milestones that would predict for overall survival (OS) and other outcomes more reliably than serial marrow cytogenetics. PATIENTS AND METHODSWe analyzed 282 patients ...
Sardana Niti - - 2011
Context:Hereditary angioedema (HAE) is a rare autosomal-dominant disease characterized by recurrent self-limiting episodes of skin and mucosal edema. Morbidity and mortality are significant, and new and pending therapies are now available to reduce the risk associated with the disease.Objective:To update the reader on new advances in HAE to improve patient ...
Rodrigues Ariana S - - 2012
The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis. Fifteen individuals with aggressive periodontitis received non-surgical periodontal treatment and 45 days after completion of treatment were treated with antibiotics. Clinical ...
Park Jae Jun - - 2011
BACKGROUND: Little is known about the factors that predict clinical relapse in Crohn's disease patients receiving thiopurine therapy to maintain remission. The objective of this study was, therefore, to investigate these factors. METHODS: A total of 82 Crohn's disease patients who received their first course of azathioprine or 6-mercaptopurine treatment ...
Tyagi Pallavi - - 2011
Ocular decompression retinopathy (ODR) is a rare complication of sudden lowering of intraocular pressure (IOP) in glaucoma and ocular hypertension. An 80-year-male, a known case of chronic open-angle glaucoma for 13 years, had his IOP controlled by multiple topical antiglaucoma medications. There was an increase in IOP, progression of optic disc ...
Suoqiang Zhai - - 2011
Microcirculatory disturbance of inner ear is probably one of the important etiological factors of sudden deafness. The purpose of this study was to evaluate the effect of retreatment on the end-stage sudden deafness. For this purpose, the patients who met with the criteria for sudden deafness and showed poor response ...
Moore Joshua L - - 2012
Pedal neuroma is a common disorder. The authors undertook a review of 32 feet in 29 patients with a symptomatic neuroma treated between January 2007 and January 2010 to evaluate the effectiveness of radiofrequency thermoneurolysis therapy in alleviating symptoms. Overall relief of symptoms was rated as complete by 24 (83%) patients, ...
Shin J - - 2011
Background:  Vitiligo is a common acquired depigmentation disorder caused by the loss of melanocytes. Despite the numerous treatment modalities that are available for vitiligo, responses to treatment are still unsatisfactory. For this reason, new treatment modalities and approaches are needed. Objectives:  The effects of fractional CO2 laser therapy followed by ...
Rodríguez-Baño Jesús - - 2011
Background. Extended-spectrum ß-lactamase-producing Escherichia coli (ESBL-EC) is an important cause of invasive infections. Alternatives to carbapenems-considered the drugs of choice-are needed because of the emergence of carbapenemase-producing enterobacteria. The efficacy of ß-lactam/ß-lactam inhibitors (BLBLI) in such infections is controversial.Methods. The authors performed a post hoc analysis of patients with bloodstream infections due ...
Marcocci Claudio - - 2011
Objective The objective of this study was to investigate side effects of glucocorticoid (GC) therapy observed by European thyroidologists during the treatment of Graves orbitopathy (GO).Design A questionnaire-based survey among members of the European Thyroid Association (ETA) who treat GO.Results A response was obtained from 128 ETA members; 115 used ...
Vescovi Paolo P Oral Medicine, Pathology and Laser-Assisted Surgery Unit, University of Parma, Parma, - - 2012
The management of bisphosphonate-related osteonecrosis of the jaws (BRONJ) is still controversial. The purpose of this study was to compare surgical and nonsurgical approaches to the treatment of BRONJ and the possible usefulness of Nd:YAG and Er:YAG lasers. One hundred and twenty-eight patients (33 males, 95 females; 52 with diagnosis ...
Steinle Nathan C - - 2011
Chronic central serous retinopathy (CSR) is characterised by frequent exacerbations and a poor visual prognosis. Very few therapies exist for chronic CSR, and the existing therapies are often ineffective. Thus, novel therapies to combat this frustrating disorder are needed. Presented here is a case detailing a patient with chronic CSR ...
Lu Yuan-Gang - - 2011
Abstract Objective: The purpose of this study was to evaluate the treatment outcome and safety of topical photodynamic therapy (PDT) with aminolevulinic acid (5-ALA) combined with surgical curettage for perianal condyloma acuminata. Background data: Condyloma acuminata is the most common sexually transmitted disease, with a high relapse rate, especially in ...
Le Quan Sang Kim-Hanh - - 2011
ContextCongenital hyperinsulinism (HI) is a common cause of hypoglycaemia in infancy. The medical treatment of diazoxide-unresponsive HI is based on a somatostatin analogue.ObjectiveThis study aims at replacing 3 daily subcutaneous octreotide (Sandostatine®, Novartis) injections by a single and monthly intramuscular injection of long-acting release (LAR) octreotide (Sandostatine LAR®, Novartis) in ...
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