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Gozdzik J J 1] Department of Clinical Immunology and Transplantation, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland [2] Department of Transplantation, Children's University Hospital in Krakow, Krakow, - - 2014
The aim of this study was to analyse the experience of Polish Pediatric Group for Hematopoietic Stem Cell Transplantation in respect to donor lymphocyte infusion procedure. The study included 51 pediatric patients with malignant (45) and non-malignant (6) diseases treated with DLI in the period 1993-2012. The indications for DLI ...
Hunter John G JG Oregon Health & Science University, Portland, Oregon. Electronic address: - - 2014
& Aims: Transoral esophagogastric fundoplication (TF) can decrease or eliminate features of gastroesophageal reflux disease (GERD) in some patients whose symptoms persist despite proton pump inhibitor (PPI) therapy. We performed a prospective, sham-controlled trial to determine if TF reduced troublesome regurgitation to a greater extent than PPIs in patients with ...
Raad Issam I II Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. Electronic address: - - 2014
Invasive aspergillosis (IA) is a life-threatening infection in severely immunocompromised haematological malignancy patients. In this study, the efficacy and safety of caspofungin, voriconazole or the combination as primary and salvage therapy in patients with IA were compared. The study included 181 patients with haematological malignancies and IA who received primary ...
Agarwal Sugandha S Departments of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital/University of Ottawa, Ottawa, Ontario, - - 2014
A 38-year-old woman was found to have a deep 3.3-cm endometriotic nodule of the bladder, confirmed by cystoscopic resection and imaging. Ultrasound also confirmed a 2.6-cm vaginal fornix implant with similar appearance to the bladder mass. The patient's primary symptoms were mild dysmenorrhea, catamenial dysuria and hematuria. The patient conceived ...
Dobesh Paul P PP University of Nebraska Medical Center, 986045 Nebraska Medical Center, Omaha, NE, 68198-6045, USA, - - 2014
Venous thromboembolism (VTE) is a major cause of morbidity, mortality, and healthcare expenditure. In the United States, approximately 0.1 % of the population experiences an initial VTE event each year. Anticoagulation therapy is the cornerstone of acute VTE treatment and for prevention of recurrent VTE events. Conventional anticoagulants, including heparin, low-molecular-weight ...
El Ghazaly Sherif A SA Orthopedic Surgery Department, Ain Shams University Hospital, Ain Shams University, Cairo, Egypt, - - 2014
Meniscus injuries are the most commonly reported in athletes. Meniscectomy is the most common treatment. Stable peripheral tears may heal, while degenerative tears do well with physical therapy. However, the exact role of physical therapy in treating symptomatic unstable meniscal tears is not known. We aimed to identify the role ...
Herten Monika M Department of Vascular and Endovascular Surgery, University of Münster, Münster, Germany. Electronic address: - - 2014
Although drug-eluting balloons (DEBs) have shown promising results treating de novo (DN) atherosclerotic lesions and appear to have been widely adopted in Europe, their long-term efficacy in the broad spectrum of femoropopliteal restenosis (RE) remains to be proven. The purpose of the study was to assess the efficacy of paclitaxel-DEBs ...
Figueira Eduardo Aleixo EA Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, 59056-000, - - 2014
This study aimed to systematically evaluate the long-term results of periodontal tissues in regenerated infrabony and furcation defects. A search of the Medline database was performed (1960 to 2012), complimented by an additional hand search. For inclusion in the review, clinical trials had to include the long-term evaluation of infrabony ...
Rothrock John F JF Department of Neurology, Renown Neurosciences Institute, Reno, NV, - - 2014
To determine whether the utilization of healthcare resources is reduced after chronic migraine patients are treated for 6 months with onabotulinumtoxinA. OnabotulinumtoxinA is indicated for headache prophylaxis in patients with chronic migraine, but its effect on healthcare resource use is unknown. We analyzed data from an open-label study of 230 ...
Glaser D A DA Department of Dermatology, Saint Louis University, St. Louis, MO, - - 2014
Bimatoprost ophthalmic solution 0.03% is approved in several countries for treating eyelash hypotrichosis. Previous trials were limited to 4 months of treatment and primarily idiopathic hypotrichosis. Evaluate long-term safety and efficacy of bimatoprost among subjects with idiopathic or chemotherapy-induced hypotrichosis. This multicentre, double-masked, randomised, parallel-group study included two 6-month treatment ...
Truchuelo M T MT University Ramón y Cajal Hospital, Madrid, Spain. Electronic address: - - 2014
The high rate of relapse of acne lesions following oral isotretinoin treatment is a common problem which remains unsolved. To avoid or minimize relapses, topical retinoids have been used for many years as maintenance treatment. However, adverse effects frequently occur. To determine the efficacy and safety of a new retinoid ...
Piccolo Francesco F Swan District Hospital, Department of Medicine, Perth, Western Australia, Australia ; - - 2014
Rationale: Intrapleural tPA/DNase therapy for pleural infection given at the time of diagnosis has been shown to significantly improve radiological outcomes. Published cases are limited to a single randomized control trial and few case reports only. Objective: Multinational observation series to evaluate the pragmatic "real-life" application of tPA/DNase treatment for ...
Ross S A SA University of Calgary, LMC Endocrinology Centres, Calgary, Alberta, - - 2014
Individuals newly diagnosed with type 2 diabetes commonly have marked hyperglycaemia. We evaluated glucose-lowering treatment strategies with linagliptin and metformin in this prevalent population, for which few dedicated studies of oral antidiabetes drugs have been conducted. Patients (n = 316) diagnosed ≤12 months with HbA1c 8.5-12.0% were randomised 1:1 to double-blind, free-combination treatment ...
Hill Robert H RH 3rd *Plastic Surgery Ohio, The Eye Center of Columbus; †Department of Ophthalmology, The Ohio State University; ‡Section of Oculofacial Plastic and Reconstructive Surgery, Ohio Health Doctors Hospital, Ohio University, Columbus Ohio; §Department of Ophthalmology, Drexel University; and ‖Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennysylvania, - - 2014
The aim of this study is to investigate whether volumetric enhancement of the infraorbital rim area or, alternatively, of the deep medial cheek, results in greater improvement of tear trough deformity. This prospective, single-blind study recruited 12 patients seeking correction of tear trough deformity. Pretreatment standardized photographs were obtained after ...
Barnes Darryl E DE Department of Orthopedics and Sports Medicine, Mayo Clinic Health System, Austin, MN, - - 2014
Elbow tendinopathy is the most common cause of elbow pain affecting active populations. Surgical excision is reserved for patients with refractory symptoms. Percutaneous ultrasonic tenotomy performed under local anesthesia also removes degenerated tissue and therefore provides an alternative treatment option to surgical excision. This investigation prospectively documented the safety and ...
van Geel N N Department of Dermatology, Ghent University Hospital, Ghent, - - 2014
Depigmentation therapy can be an option in adults with extensive and refractory vitiligo. Remaining pigmented patches can be removed using depigmentation creams (monobenzyl ether of hydroquinone 20%), laser therapy or cryotherapy. In contrast to cream treatment, laser therapy and cryotherapy are fast and targeted methods, capable of destroying melanocytes selectively ...
Petrovic-Lazic Mirjana M Faculty of Special Education and Rehabilitation, University of Belgrade, Belgrade, Serbia; ENT Clinic, Zvezdara Hospital and Clinical Centre, Belgrade, - - 2014
The aim of the study was to assess the effect of endolaryngeal phonomicrosurgery (EPM) and voice therapy in patients with vocal fold polyps using perceptual and acoustic analysis before and after both therapies. The acoustic tests and perceptual evaluation of voice were carried out on 41 female patients with vocal ...
Tristram Amanda A HPV Research Group, School of Medicine, Cardiff University, Cardiff, - - 2014
Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreated, can become cancerous. Currently, the standard treatment for patients with vulval intraepithelial neoplasia is surgery, but this approach does not guarantee cure and can be disfiguring, causing physical and psychological problems, particularly in women of reproductive ...
Ng Ka Ying Bonnie KY Gastroenterology Department, Ealing Hospital, Southall, - - 2014
Refractory coeliac disease (RCD) is characterised by recurrent or persistent malabsorptive symptoms and villous atrophy, despite strict adherence to a gluten-free diet for at least 6 months and where other causes of malabsorption including malignancy have been excluded. There is limited evidence and guidance on the effective management of these ...
Trad Karim Sami - - 2014
The aim of this randomized, crossover study was to determine if transoral fundoplication (TF) could further improve clinical outcomes in partial responders to high-dose (HD) proton-pump inhibitor (PPI) therapy and to evaluate durability of TF. In seven United States centers, patients with hiatal hernia <=2 cm and abnormal esophageal acid ...
Kennedy N A NA Gastrointestinal Unit, Western General Hospital, Edinburgh, - - 2014
Thiopurines (azathioprine and mercaptopurine) remain integral to most medical strategies for maintaining remission in Crohn's disease (CD) and ulcerative colitis (UC). Indefinite use of these drugs is tempered by long-term risks. While clinical relapse is noted frequently following drug withdrawal, there are few published data on predictive factors. To investigate ...
Huttner Benedikt B VA Salt Lake City Health Care System, IDEAS Center, Salt Lake City, UT 84148, USA Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, - - 2014
To assess rates of starting or stopping antibiotics across different hospitals. We used barcode medication administration data to measure antibiotic use on acute-care wards in 128 Veterans Affairs medical centres (VAMCs) in 2010. A treatment day (TD) was defined as the administration of any antibiotic on a given day. A ...
Del Fresno M Rosa MR Pediatric Rheumatology Unit and - - 2014
Recurrent pericarditis is a troublesome complication of idiopathic acute pericarditis and occurs more frequently in pediatric patients after cardiac surgery (postpericardiotomy syndrome). Conventional treatment with nonsteroidal antiinflammatory drugs, corticosteroids, and colchicine is not always effective or may cause serious adverse effects. There is no consensus, however, on how to proceed ...
Schomacher Markus M Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Berlin, - - 2014
Surgical treatment of a pyogenic spondylodiscitis (PSD) involves a fixation and debridement of the affected segment combined with a specific antibiotic therapy. To achieve a proper stability and to avoid pseudarthrosis and kyphotic malposition many surgeons favour the interposition of an anterior graft. Besides autologous bone grafts titanium (TTN) cages ...
Reis Leonardo Oliveira LO Department of Urology, University of Campinas, Unicamp, Campinas, São Paulo, - - 2014
Purpose After a successful pyeloplasty at 3 to 6 months, the question remains whether children need a long follow-up. Methods The medical charts of patients with long-term follow-up (> 5 years), who underwent dismembered pyeloplasty for uretero-pelvic junction obstruction (UPJO) from May 1998 to May 2007, excluding those with bilateral UPJO, solitary ...
Ishikura Kenji K Department of Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan, - - 2014
To investigate the long-term outcome in children with frequently relapsing nephrotic syndrome (FRNS) we conducted a follow-up of a previous randomized controlled trial (RCT) 10 years after the initiation of the treatment protocol. We previously conducted an RCT on the efficacy of cyclosporine for treating children with FRNS. After 2 years of ...
Pereira Vitor Mendes VM Interventional Neuroradiology Unit, Service of Neuroradiology, University Hospitals of Geneva, Geneva, Switzerland Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, - - 2014
Flow diverter stents (FDS) have been described as a breakthrough in the treatment of intracranial aneurysms. Of the various flow diverter models, the Pipeline device has been the main approved and used device, with established and good long-term results. To present the first series of patients treated with its new ...
Tan Shu-Tao ST Department of Urology, Shengjing Hospital, China Medical University, China - - 2014
Bleeding stomal varices after ileal conduit urinary diversion are rare, but they can develop in patients with portal venous hypertension caused by cirrhosis. We report the case of a 68-year-old man who developed stomal haemorrhage two months after radical cystectomy and ileal conduit urinary diversion to treat invasive bladder cancer. ...
Batirel Ayse A Infectious Diseases and Clinical Microbiology, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Semsi Denizer Cd. E-5 Karayolu Cevizli Mevkii, 34890 Kartal, Istanbul, Turkey. Electronic address: - - 2014
To compare responses to tenofovir (TDF) and entecavir (ETV) therapy. This was a multicenter retrospective study including treatment-naïve patients with chronic hepatitis B (CHB) who received TDF or ETV. The primary end-points were undetectable HBV-DNA at 48 weeks and serological and biochemical responses. Out of 195 CHB patients, 90 (46%) ...
Maffi Paola P 1 Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy. 2 Department of Surgery, Cell Isolation and Transplantation Center, University of Geneva, Genève, Switzerland. 3 Department of Radiology and Center for Experimental Imaging, IRCCS San Raffaele Scientific Institute, Milan, Italy. 4 Vita-Salute San Raffaele University, Milan, Italy. 5 Correspondence to: Prof. Lorenzo Piemonti, MD, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Antonio Secchi, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, - - 2014
Our final objective is to develop an adoptive therapy with tolerogenic donor-specific type 1 T regulatory cells for patients with type 1 diabetes undergoing islet transplantation. The achievement of this objective depends on the availability of an immunosuppressive treatment compatible with the survival, function, and expansion of type 1 T ...
de Andrés-Nogales F F Pharmacoeconomics & Outcomes Research Iberia (PORIB), Pozuelo de Alarcón, Madrid, España. Electronic address: - - 2014
Oral anticoagulant therapy is complex due to the need for control and the hemorrhagic risk the therapy entails. This study aims to determine the standard clinical practice in the treatment for preventing stroke in patients with nonvalvular atrial fibrillation (NVAF) in Spain. The Real Evidence of Anti Coagulation Treatment in ...
Pradelli J J Infectiologie, Hôpital de l'Archet 1, Centre Hospitalier Universitaire de Nice, Université de Nice Sophia-Antipolis, BP 3079, 06202, Nice, - - 2014
Guidelines for inpatients with community-acquired pneumonia (CAP) propose to use respiratory fluoroquinolone (RFQ) and/or third-generation cephalosporins (Ceph-3). However, broad-spectrum antibiotic therapy is associated with the emergence of drug-resistant bacteria. We established a guideline in which RFQ and Ceph-3 were excluded as a first course. Our aim was to evaluate the ...
Ansari Julia G - - 2014
Atrial fibrillation affects approximately 5 million patients in the United States. The rate of stroke in adults with atrial fibrillation depending on their risk factors varies between 1-20% annually. Anticoagulation with vitamin K antagonists such as warfarin has been the mainstay therapy but it is cumbersome and requires close follow-up. ...
Silverman Steven H SH Department of Surgery, Florida State University Medical School, Sarasota, Fla. Electronic address: - - 2014
Renal artery in-stent restenosis (RAISR) is not an infrequent occurrence and may be in part responsible for the failure of renal stents to improve clinical outcome. A variety of treatments have been used to restore patency, with mixed results. These include repeated percutaneous transluminal renal angioplasty (PTRA), repeated PTRA with ...
Golden Matthew R MR From the *Center for AIDS and STD, University of Washington, Seattle, WA; and †Public Health-Seattle & King County, Seattle, - - 2014
US gonorrhea treatment guidelines recently changed to promote ceftriaxone as first-line therapy. Because ceftriaxone requires intramuscular administration, this could lead some patients to go untreated. We used an arithmetic model to compare the number of persons with gonorrhea who would be successfully treated with continued use of oral therapies versus ...
- - 2014
Surgery can present a management dilemma for gynecologists whose patients receive chronic antithrombotic therapy because the risk of hemorrhagic complications must be balanced against the risk of thromboembolic complications. Interruption of antithrombotic therapy to reduce perioperative bleeding poses a significant risk of recurrent thromboembolic events. Patients who receive chronic antithrombotic ...
Li Hui H Department Nephrology, The Xiangya Hospital of Central South University , Changsha, Hunan , China - - 2014
Abstract Objective: To investigate the treatment efficacy of adefovir dipivoxil combined with a corticosteroid on hepatitis B virus-associated glomerulonephritis (HBV-GN). A total of 38 patients with nephrotic syndrome induced by HBV-GN were treated for 36 weeks between 2010 and 2012. The efficacy analysis showed that 11 patients achieved complete remission ...
Pourmand Gholamreza G Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, - - 2014
To evaluate if addition of l-carnitine therapy to standard varicocelectomy adds any extra benefit in terms of improvement in semen parameters or deoxyribonucleic acid (DNA) damage. One hundred patients enrolled in this study and were randomly divided into 2 groups (50 patients in each group). In group 1, standard inguinal ...
Liu Xiangdong X Department of Ophthalmology, Jinshan Hospital, Fudan University, Shanghai 201508, - - 2014
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) drugs and corticosteroids are being widely used to treat diabetic macular edema (DME). The purpose of this study was to evaluate further the efficacy and safety of intravitreal bevacizumab (IVB) alone in comparison with intravitreal bevacizumab combined with triamcinolone acetonide (IVB/IVT) in the treatment ...
Greig Sarah L SL Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand, - - 2014
Dabigatran etexilate (Pradaxa(®), Prazaxa(®)) has recently been approved for the treatment of acute venous thromboembolism (VTE) and prevention of VTE recurrence. Dabigatran etexilate is an oral prodrug of dabigatran, a selective, reversible, competitive, direct thrombin inhibitor. Dabigatran etexilate has a wide therapeutic range that allows for fixed-dose administration without the ...
Jones Randolph Todd C RT New York University, NYU Vein Center, 530 1st Avenue, New York, NY 10016 USA. - - 2014
Fifteen years ago, radiofrequency ablation of the saphenous vein was introduced as a new and minimally invasive modality for the treatment of superficial venous insufficiency. Three years later, it was followed by endovenous laser ablation. These procedures have revolutionized the treatment of superficial venous insufficiency and have caused a dramatic ...
Barton Andrea L AL Department of Pharmacy, Texas Children's Hospital, Houston, - - 2014
To report our experience with high-dose propranolol monotherapy for prophylaxis and treatment of infant supraventricular arrhythmias (SAs). Patients <1 year of age initiated on enteral propranolol as inpatients for management of SA were identified during a 10-year time period from the Texas Children's Hospital pharmacy database. Patients were included if they ...
Michalewski Janusz J Ophthalmic Clinic Jasne Blonia, Rojna 90, Lodz, Poland; Third Municipal Hospital, K. Jonscher, Milionowa 14, Lodz, - - 2014
This study aimed to report on the efficacy of 1 dose of aflibercept in bevacizumab nonresponders. This was a retrospective, single-centre, interventional, noncomparative study. This study retrospectively analyzed 23 patients with persistent intraretinal or subretinal fluid treated with 6 or more monthly bevacizumab injections. Patients were switched to 1 dose ...
Sedal L L Neuroimmunology Clinic, Clinical Neurosciences, St Vincent's Hospital Melbourne, Melbourne, Victoria, - - 2014
Multiple sclerosis was without effective disease-modifying therapy for many years. The introduction of the injectable therapies (interferon and glatiramer acetate) some 20 years ago was considered a major advance. Recent years have heralded a revolution in treatment options with the introduction of intravenous natalizumab and, even more recently, three oral ...
Ehsani Amir Hooshang AH Razi Hospital, Tehran University of Medical Sciences, Tehran, - - 2014
The combination of pulsed dye laser (PDL) and topical propranolol are used with variable effectiveness for the treatment of infantile hemangiomas (IH), particularly for superficial lesions. The aim of this study was to investigate whether the therapeutic efficacy of prescribing topical propranolol along with PDL was superior to PDL therapy ...
Westendorp Willeke F - - 2014
Infections occur in 30% of stroke patients and are associated with unfavorable outcomes. Preventive antibiotic therapy lowers the infection rate after stroke, but the effect of preventive antibiotic treatment on functional outcome in patients with stroke is unknown. The PASS is a multicenter, prospective, phase three, randomized, open-label, blinded end-point ...
Patel Anup A New Haven and Hartford, Conn.; Charlottesville, Va.; Pittsburgh, Pa.; and DeKalb, Ill. From the Section of Plastic and Reconstructive Surgery, Yale University School of Medicine; the Craniofacial Surgery Center, Connecticut Children's Medical Center; the Department of Neurosurgery, University of Virginia School of Medicine; the University of Pittsburgh School of Medicine; and the Department of Psychology, Northern Illinois - - 2014
The relationship between surgical age and long-term neuropsychological outcomes in sagittal-suture craniosynostosis remains equivocal. Whole-vault cranioplasty and strip craniectomy are performed at various times in individuals with sagittal-suture craniosynostosis. This study used comprehensive neurological testing to examine the relationship between age at time of surgery and long-term neuropsychological function. Seventy ...
Hosseini Vahid V Inflammatory Diseases of the Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari, - - 2014
BACKGROUND Furazolidone has been used as an alternative for clarithromycin or metronidazole in Helicobacterpylori (H.pylori) eradication regimens. In Iran, 14-day Furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. Therefore, we designed a study to compare the efficacy of two 10-day triple regimens ...
Fang Yu-Qing YQ Centre for Liver Diseases and Department of Infectious Diseases (Y-QF, WJ, JL, Y-QD, YW, MY, G-QW), Peking University First Hospital, Xicheng District, Beijing; and Department of Infectious Diseases (D-XL), Sixth Hospital of Shenyang, Heping District, Shenyang, Liaoning, - - 2014
To the best of our knowledge, this is the first study to address the use of glucocorticoids in the comparatively special population of pure primary biliary cirrhosis (PBC) patients who have high levels of immunoglobulin G (IgG) and transaminases but do not have PBC-autoimmune hepatitis overlap syndrome. Ursodeoxycholic acid (UDCA) ...
Kim Sung Han SH Department of Neurosurgery, Gangnam Severance Hospital, The Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, - - 2014
To analyze the clinical courses and outcomes after anterior lumbar interbody fusion (ALIF) for the treatment of postoperative spondylodiscitis. A total of 13 consecutive patients with postoperative spondylodiscitis treated with ALIF at our institute from January, 1994 to August, 2013 were included (92.3% male, mean age 54.5 years old). The ...
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