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Rayess Nadim N Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, - - 2014
To determine three year treatment outcomes after 1 to 3 years of ranibizumab or bevacizumab therapy using a "treat and extend" regimen for patients with neovascular age-related macular degeneration (AMD). Retrospective, interventional, consecutive case series. 212 eyes from 196 patients diagnosed with treatment naïve neovascular AMD between January 2009 till ...
Zarranz-Ventura Javier J Bristol Eye Hospital, Bristol, United Kingdom; Gloucestershire Hospitals National Health Service Trust, Cheltenham, United Kingdom; Institut Clínic d´Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain. Electronic address: - - 2014
To identify clinical outcomes and treatment patterns of intravitreal dexamethasone implant (Ozurdex®) in non-infectious uveitis in the clinical setting. Multicenter retrospective cohort study. 82 eyes (63 patients) receiving 142 implant injections over 35 months were included. Treatment indication, uveitis diagnosis, visual acuity, intraocular pressure, vitreous haze score, central retinal thickness ...
Mesquida Marina M Institut Clinic d'Oftalmologia, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, - - 2014
To report the long-term efficacy and safety of the interleukin-6 receptor antagonist tocilizumab for refractory uveitis-related macular edema (ME). Retrospective cohort study. Eyes with uveitis seen at a single tertiary referral center for which ME was the principal cause of reduced visual acuity. Data were obtained by standardized chart review. ...
Gajofatto Alberto A Department of Neurological and Movement Sciences, University of Verona, Verona, - - 2014
Background: It is unclear whether natalizumab and fingolimod have analogous efficacy for relapsing-remitting multiple sclerosis (RRMS). Objective: To compare the outcome of RRMS patients treated with either therapy. Methods: RRMS patients treated with natalizumab or fingolimod at Verona Hospital, Italy, were included. The study design was retrospective, based on prospectively ...
Pollack Charles V CV Jr Department of Emergency Medicine, Pennsylvania Hospital, University of - - 2014
Venous thromboembolism (VTE) is a disease spectrum that ranges from deep vein thrombosis (DVT) to pulmonary embolism (PE). Rapid diagnosis and treatment of VTE by emergency care providers are critical for decreasing patient mortality, morbidity, and the incidence of recurrent events. Recent American College of Chest Physicians guidelines recommend initial ...
Durão Ana Reis AR a Invited Assistant, Department of Dental Radiology, Faculty of Dental Medicine, University of Porto, - - 2014
Objective: To evaluate the impact of additional lateral cephalometric radiography in orthodontic diagnosis and treatment planning. Materials and Methods: Forty-three patients seeking orthodontic treatment, and for whom pretreatment diagnostic records were available, were randomly selected. Ten qualified orthodontists were involved in this study. The patients' records included three photographs of ...
Holz Frank G FG Department of Ophthalmology, University of Bonn, Bonn, - - 2014
Real-life anti-vascular endothelial growth factor (VEGF) therapy use in patients with wet age-related macular degeneration (wAMD) was assessed in a retrospective, observational study in Canada, France, Germany, Ireland, Italy, the Netherlands, UK and Venezuela. Medical records of patients with wAMD, who started ranibizumab treatment between 1 January 2009 and 31 ...
Casale Maddalena M Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Second University of Naples, Naples, - - 2014
Iron overload in β-thalassemia major typically results in iron-induced cardiomyopathy, liver disease and endocrine complications. We examined the incidence and progression of endocrine disorders (hypothyroidism, diabetes, hypoparathyroidism, hypogonadism), growth and pubertal delay, and bone metabolism disease during long-term deferasirox chelation therapy in a real clinical practice setting. We report a ...
Türkoğlu E B EB Akdeniz University, Department of Ophthalmology, 07100 Antalya, Turkey. Electronic address: - - 2014
To compare the outcomes in the management of traumatic hyphema treated with topical corticosteroid plus supportive therapy versus only supportive therapy. In this retrospective study, 206 patients were divided into two groups; group I, 98 eyes were treated with topical corticosteroid 12×1 and supportive therapy including bed rest, keeping the head elevated (45 degrees), ...
Siewe Jan - - 2014
The 360[degree sign] fusion of lumbar segments is a common and well-researched therapy to treat various diseases of the spine. But it changes the biomechanics of the spine and may cause adjacent segment disease (ASD). Among the many techniques developed to avoid this complication, one appears promising. It combines a ...
Korkmaz Levent L Kayseri Training and Research Hospital, Neonatology Unit, Kayseri, Turkey. E-ma-il: - - 2014
Congenital hypothyroidism (CH) is the most common endocrine pathology in neonates. Inappropriate treatment of CH is complicated by irreversible brain damage or low IQ score. Hormone replacement therapy with L-thyroxine (L-T4) is sufficient for a very large proportion of patients. However, during treatment, the patient needs to be carefully monitored ...
Johannsson Gudmundur G Department of Endocrinology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
Glucocorticoid replacement therapy in patients with adrenal insufficiency (AI), whether primary (Addison's disease) or secondary (due to hypopituitarism), has been established for some 50 years. The current standard treatment regimen involves twice- or thrice-daily dosing with a glucocorticoid, most commonly oral hydrocortisone. Based on previous small-scale studies and clinical perception, ...
Pan Szu-Yu SY Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, - - 2014
We aimed to examine the association between preoperative use of statins and postoperative acute kidney injury (AKI) in patients undergoing major surgery by performing a systemic review and meta-analysis. MEDLINE and EMBASE, from inception to April 2013, and the reference lists of related articles were searched for relevant studies. Trials ...
Xie Qing Q Shanghai Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai, - - 2014
 Treatment with peginterferon alfa-2a (40KD) results in hepatitis B 'e' antigen (HBeAg) seroconversion 6 months post-treatment in up to 36% of HBeAg-positive chronic hepatitis B patients. This study explored the efficacy of a novel combination of peginterferon alfa-2a and entecavir (ETV), a potent nucleoside analog.  In total, 218 treatment-naive Chinese ...
Ghanem Ramon Coral RC *Cornea Department, Sadalla Amin Ghanem Eye Hospital, Joinville, Brazil; and †Univille University, Joinville, - - 2014
To describe the use of topical 0.03% tacrolimus in patients with symptomatic corneal subepithelial infiltrates (SEIs) secondary to adenoviral keratoconjunctivitis (AK) that were resistant to tapering of corticosteroid eye drops. This was a prospective, nonrandomized, noncomparative interventional case series that included consecutive patients treated with tacrolimus for resistant SEIs after ...
Goldberg Naomi R NR Department of Ophthalmology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, - - 2014
To evaluate the success of single-agent immunosuppression for patients with the posterior uveitides, birdshot chorioretinitis, multifocal choroiditis with panuveitis, and punctate inner choroiditis. Retrospective case series. Setting: Tertiary care uveitis practices. Population: Patients initiated on immunomodulatory therapy. Intervention: Patients were treated with prednisone 1 mg/kg and mycophenolate 2 gm daily. ...
Hirschl Mirko M Department of Angiology, Hanusch Hospital, Vienna, - - 2014
For decades, heparins and vitamin K antagonists (VKAs) have been the gold standards in therapy of venous thromboembolism (VTE). The advent of factor IIa and Xa inhibitors provides new therapeutic options. The aim of this analysis is to compare the currently available new oral anticoagulants (NOACs) with VKAs and also ...
Forestier Romain J RJ Centre de recherche rhumatologique et thermal, Aix-les-Bains, - - 2014
Physical therapy has not been evaluated much for the treatment of chronic venous insufficiency before. The question is whether balneohydrotherapy and usual care combined is superior to usual care alone. In a randomized trial comparing spa therapy versus waiting list patients were treated on an out-patient basis in a private ...
Sood Ajit A Dayanand Medical College and Hospital, Punjab, - - 2014
Introduction. Standard treatment for patients with chronic hepatitis C genotype 1 (CHC G-1) infection includes pegylated interferon plus ribavirin (PEG-RBV) for 48 weeks. Shorter treatment regimen would be more acceptable due to lower cost and fewer side-effects. We aimed to compare the efficacy of 36 week PEG-RBV therapy with standard ...
Faisal Nabiha N Toronto General Hospital, University of Toronto. Ontario, - - 2014
Introduction. Hepatitis C (HCV) continues to be the leading indication for liver transplantation (LT). Sustained virological response (SVR) rates to pegylated interferon (PEG-IFN) and ribavirin (RBV) therapy for recurrent HCV in Genotype 1 (G1) LT recipients have been disappointing (30-40%). Experience with triple therapy using protease inhibitors (PI) boceprevir (BOC), ...
Vela M F MF Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ, - - 2014
Treatment options for achalasia include oral pharmacologic therapy, endoscopic injection of botulinum toxin, pneumatic dilation, and myotomy (conventionally by laparoscopy, but more recently by an endoscopic approach). Oral pharmacologic agents have fallen out of use because of insufficient efficacy and frequent side effects. Endoscopic injection of botulinum toxin is safe ...
Leybovich Martin - - 2014
This study compared two treatments for mild noncarious cervical lesions (NCCLs): a subepithelial connective tissue graft (CTG) versus a Class V composite resin restoration (CRR). Twenty-six sites with NCCLs were randomly assigned to be treated by CTG or CRR. Periodontal health parameters and dentinal hypersensitivity (DH) were recorded at baseline ...
Levy Jerrold H JH Duke University School of Medicine, Divisions of Cardiothoracic Anesthesiology and Critical Care, Duke University Hospital, 2301 Erwin Road, Durham, NC 27710, USA. Electronic address: - - 2014
Bleeding is a significant complication of anticoagulant therapy. With the emergence of new oral anticoagulants (NOACs; ie, direct factor IIa or Xa inhibitors), this risk is further compounded by the lack of validated reversal strategies for these agents. Emerging postmarketing evidence suggests that the bleeding risks are in line with ...
Zhao Dahang D Department of Pediatric Orthopaedics, Xin-Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
Ponseti clubfoot treatment has become more popular during the last decade because of its high initial correction rate. But the most common problem affecting the long-term successful outcome is relapse of the deformity. Non-compliance with Ponseti brace protocol is a major problem associated with relapse. Although more comfortable braces have ...
Gray M M Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, - - 2014
Historically, congenital pulmonary lymphangiectasia (CPL) has had poor treatment outcomes despite aggressive therapy. There are recent reports of ethiodized oil (Lipiodol) lymphangiography successfully treating lymphatic leakage in adults. In this report, we describe two infants with CPL complicated by chylothoraces successfully treated by instillation of ethiodized oil into the lymphatic ...
Wallace Carol A CA From the Seattle Children's Hospital and Research Institute, Seattle, Washington; University of Utah, Pediatrics, Salt Lake City, Utah; Cleveland Clinic, Cleveland, Ohio; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of California at San Francisco, San Francisco, California; Duke University Medical Center, Pediatrics, Durham, North Carolina; Ohio State University and Nationwide Children's Hospital, Pediatrics, Columbus, Ohio; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Steven and Alexandra Cohen Children's Medical Center of New York, New York; Stanford University School of Medicine, Palo Alto, California; Texas Scottish Rite Hospital, Dallas, Texas; Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA. Supported by grants from US National Institute of Arthritis and Musculoskeletal and Skin Diseases: 5R01AR049762-04; AMGEN; and the Howe Endowment for Juvenile Rheumatoid Arthritis Research. C.A. Wallace, MD; S. Ringold, MD, MS, Seattle Children's Hospital and Research Institute; J. Bohnsack, MD, University of Utah; S.J. Spalding, MD, Cleveland Clinic; H.I. Brunner, MD, MSc, Cincinnati Children's Hospital Medical Center; D. Milojevic, MD, University of California at San Francisco; L.E. Schanberg, MD, Duke University Medical Center; G.C. Higgins, PhD, MD, Ohio State University and Nationwide Children's Hospital; K.M. O'Neil, MD, Oklahoma University Health Science Center, now at Riley Hospital for Children, Indianapolis, Indiana; B.S. Gottlieb, MD, MS, Steven and Alexandra Cohen Children's Medical Center of New York; J. Hsu, MD, MS, Stanford University School of Medicine; M.G. Punaro, MD, Texas Scottish Rite Hospital; Y. Kimura, MD, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center; A. Hendrickson, MPH, Seattle Children's Hospital and Research Institute. Address correspondence to Dr. C.A. Wallace, Professor of Pediatrics, Division of Rheumatology, University of Washington and Seattle Children's Hospital, 4800 Sand Point Way NE, R-5420, Seattle, Washington 98105, USA. E-mail: cwallace@u.washington.edu. Accepted for publication June 25, - - 2014
To follow children with juvenile idiopathic arthritis (JIA) who had completed at least 6 months of the TRial of Early Aggressive Therapy (TREAT) clinical study for an additional 2 years, describing safety of early aggressive treatment, disease activity, function, and duration of clinical inactive disease (CID) during followup. Children were ...
Pauls Rachel N RN From the *Division of Urogynecology and Reconstructive Pelvic Surgery, TriHealth Good Samaritan Hospital, †Center for Pelvic Floor and Core Rehabilitation, and ‡Hatton Institute for Research and Education, TriHealth, Cincinnati, - - 2014
Pelvic floor physical therapy (PFPT) is often used as a treatment of pelvic floor disorders and may improve function after pelvic reconstructive surgery. However, the long-term impact of this modality is not understood. This randomized controlled trial compared PFPT to the standard care in women undergoing vaginal reconstruction. The intervention ...
Li Hongyang H Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing 100853, - - 2014
Optic neuritis (ON) is often the first symptom of multiple sclerosis (MS) and neuromyelitis optica (NMO) while there has been very little research reported on ON combined with Sjögren's syndrome (SS). The aim of this study is to provide different treatments and services for and NMO patients combined with SS. ...
Galvan Garcia Hector Ricardo HR Dermatology Hospital, Dermatosurgery, Guadalajara, Jalisco, - - 2014
Laser Treatment of onychomycosis is a quick and easy method without complications. Laser therapy is efficient for the Treatment of onychomycosis. One hundred and twenty patients with a KOH (+) confirmed clinical diagnosis of onychomycosis were included in this study, all of the patients were treated in a single sesión ...
Yoshizawa Naohiko N Department of Gastroenterology, Aichi Cancer Center - - 2014
A patient in her 60s was referred to our hospital with pancreatic enlargement. Laboratory data and endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) revealed a nonfunctioning pancreatic neuroendocrine tumor (WHO classification 2010 G2). Resection was contraindicated because of portal vein invasion and extensive collateral vascularization. Everolimus (10 mg/day) was started after ...
Güngör Sule S Department of Dermatology, Okmeydanı Training and Research Hospital, Istanbul, - - 2014
Striae distensae or stretch marks are atrophic linear dermal scars with epidermal atrophy. There are many therapeutic options for management, but no consistently effective modality is available yet. We compared the efficacy of 1064 nm long pulse (LP) Nd: YAG laser and 2940 nm variable square pulse (VSP) erbium: YAG ...
Esmaili Nafiseh N Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
Pemphigus is an autoimmune blistering mucocutaneous disorder. Common treatments include corticosteroids and immunosuppressive drugs. This study aimed to assess the therapeutic effects of oral prednisolone along with the common adjuvant therapy in pemphigus vulgaris.   Eighty-seven patients with pemphigus vulgaris from the first stage of a previously randomized clinical trial ...
Xiong Ji J Department of Gastroenterology, Institute of Surgery Research, Daping Hospital (JX, SL, PZ, QL, YW, YY, TW, LL, DC); Department of Epidemiology, College of Preventive Medicine (XM); and Center for Clinical Epidemiology and Evidence-Based Medicine, Third Military Medical University, Chongqing, People's Republic of China - - 2014
Proton pump inhibitor (PPI) was the main prescription for gastric ulcer after endoscopic submucosal dissection (ESD). Some randomized controlled trials showed that a combination of rebamipide and PPI appears to be more efficient than PPI alone for the treatment of ESD-induced gastric ulcer. However, the sample sizes in these trials ...
Serra Maíra Chiarelli MC Divisione Melanoma, Istituto Europeo di Oncologia, Milano, - - 2014
A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital ...
Hevia Oscar - - 2014
Utilizing a soft-tissue filler that is more fluid and less resistant to deformation may be advantageous for correction of infraorbital hollows.<BR /> The objective of this study was to determine the safety and efficacy of the latest hyaluronic acid filler, created with a cohesive polydensified matrix, with a low elasticity ...
Sundar Shyam S Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, - - 2014
India is home to 60% of the total global visceral leishmaniasis (VL) population. Use of long-term oral (e.g. miltefosine) and parenteral drugs, considered the mainstay for treatment of VL, is now faced with increased resistance, decreased efficacy, low compliance and safety issues. The authors evaluated the efficacy and safety of ...
Farber Alik A Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston, MA. Electronic address: - - 2014
Critical limb ischemia (CLI) is the most severe form of peripheral arterial disease and is associated with a significant risk of limb loss. It is currently treated with limb revascularization by a variety of specialists. Although both open vascular bypass and endovascular therapy are offered to patients with infrainguinal peripheral ...
Barth Jodi Maron JM National Rehabilitation Hospital, Regional Rehab at Montrose, Rockville, MD, - - 2014
We conducted a retrospective chart review to determine the effectiveness of treating idiopathic facial palsy with mirror book therapy in conjunction with facial physical rehabilitation. We compared outcomes in 15 patients who underwent mirror book therapy in addition to standard therapy with those of 10 patients who underwent standard rehabilitation ...
- - 2014
Background: The main clinical manifestations of autoimmune thyroid diseases are Graves' disease (GD) and Hashimoto's thyroiditis (HT). Graves' disease is the cause of most cases of hyperthyroidism in childhood. Indications for radical therapy (surgery or 131I treatment) in children are still a matter of discussion, as sustained (sometimes very long) ...
Salome G M GM Sapucaí Valley University (UNIVÁS), Pouso Alegre, MG, - - 2014
• To assess self-esteem in patients with venous leg ulcers treated with Unna's boot. • A descriptive, analytic, clinical study was conducted from June 2010 to May 2011 in an outpatient wound care clinic in São Paulo, Brazil. Patients of both sexes, aged ≥18 years, who had had a venous ...
Mummolo Stefano - - 2014
This study evaluated the efficacy of a xanthan-based chlorhexidine gel (Xan-CHX) used as antiseptic in periodontal pockets after scaling and root planing in patients with generalized mild-severe chronic periodontitis. 30 systemically healthy patients, 15 males and 15 females (mean age 54,1 ± 6,9 years), diagnosed for chronic periodontitis were enrolled ...
Hong Wandong W Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, - - 2014
There is no consensus regarding the most appropriate methods (i.e., the side-by-side versus the stent-in-stent technique) for placing bilateral stents for malignant hilar biliary obstructions. We aimed to perform a quantitative review of the published data regarding the clinical efficacy of the side-by-side and stent-in-stent bilateral drainage techniques for hilar ...
Teivelis Marcelo Passos MP Hospital Israelita Albert Einstein, Vascular Surgery, São Paulo, SP, - - 2014
Primary hyperhidrosis usually affects the hands, armpits, feet and cranio-facial region. Sweating in other areas is common in secondary hyperhidrosis (after surgery or in specific clinical conditions). Oxybutynin has provided good results and is an alternative for treating hyperhidrosis at common sites. Our aim was to evaluate the efficacy of ...
Ze EunYoung E Department of Internal Medicine, Chung-Ang University College of Mediciner, Seoul, - - 2014
Adefovir (ADV) and lamivudine (LAM) combination therapy (ADV+LAM) has been a useful option for patients with LAM-resistant (LAM-r) chronic hepatitis B (CHB). However, the long-term outcomes of LAM+ADV and 1-mg entecavir (ETV) rescue therapies have still been limited. The aim of this study was to determine the long-term outcomes of ...
Ahn Sung Soo SS Department of Internal Medicine, Yonsei University College of Medicine, Seoul, - - 2014
This study assessed the antiviral efficacy and safety of tenofovir disoproxil fumarate (TDF) for up to 12 months in Korean treatment-naïve chronic hepatitis B (CHB) patients. A total of 411 treatment-naïve CHB patients who had been treated with TDF for at least 3 months (median 5.6) were consecutively enrolled. Clinical, ...
Kim Jeong Han JH Department of Internal Medicine, Konkuk University School of Medicine, Seoul, - - 2014
Quantitation of hepatitis B surface antigen (HBsAg) is an increasingly popular method to determine the treatment response in chronic hepatitis B (CHB) patients. The clinical value of HBsAg level measurement during rescue therapy for lamivudine (LMV)-resistant CHB patients have not been evaluated to date. Therefore, this study investigated the correlation ...
De Bk B Department of Medicine, Medical College, Kolkata, West Bengal, - - 2014
Prednisolone and pentoxifylline (PTX) have been shown to be individually useful in severe alcoholic hepatitis with Maddrey discriminant function (MDF) score ≥32. Previous report suggests that PTX is probably superior to prednisolone alone. However the efficacy of PTX and prednisolone combination over PTX alone in the management of acute alcoholic ...
Pereira-Lima Júlio C JC Department of Gastroenterology and Hepatology, Santa Casa Hospital/Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil, - - 2014
Postoperative esophageal strictures frequently recur. We assessed the efficacy of injecting triamcinolone after bougie dilation in comparison to dilation alone. In a double-blind randomized fashion, 19 patients (68 % male with mean age of 53-years old) with non-dilated esophagogastric complex strictures after esophagectomy with gastric pull-up were assigned to receive dilation ...
Myers Kevin R KR Department of Orthopaedics, North Shore-Long Island Jewish Medical Center, New Hyde Park, New - - 2014
There are two scaffold products designed for meniscal reconstruction or substitution of partial meniscal defects that are currently available in the Europe: the collagen meniscal implant (CMI; Ivy Sports Medicine, Gräfelfing, Germany) and the polymer scaffold (PS; Actifit, Orteq Bioengineering, London, United Kingdom). The CMI has demonstrated improved clinical outcomes ...
Stone Scellig S D SS Department of Neurosurgery, Boston Children's Hospital, Boston, - - 2014
Object Combined endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) enhances the likelihood of shunt freedom over ETV alone, and thus avoidance of shunt-related morbidity, in hydrocephalic infants. To date, virtually all published reports describe experiences in Africa, thus hampering generalization to other parts of the world. Here, the authors ...
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