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van Geel N N Department of Dermatology, Ghent University Hospital, Ghent, - - 2014
Depigmentation therapy can be an option in adults with extensive and refractory vitiligo. Remaining pigmented patches can be removed using depigmentation creams (monobenzyl ether of hydroquinone 20%), laser therapy or cryotherapy. In contrast to cream treatment, laser therapy and cryotherapy are fast and targeted methods, capable of destroying melanocytes selectively ...
Petrovic-Lazic Mirjana M Faculty of Special Education and Rehabilitation, University of Belgrade, Belgrade, Serbia; ENT Clinic, Zvezdara Hospital and Clinical Centre, Belgrade, - - 2014
The aim of the study was to assess the effect of endolaryngeal phonomicrosurgery (EPM) and voice therapy in patients with vocal fold polyps using perceptual and acoustic analysis before and after both therapies. The acoustic tests and perceptual evaluation of voice were carried out on 41 female patients with vocal ...
Tristram Amanda A HPV Research Group, School of Medicine, Cardiff University, Cardiff, - - 2014
Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreated, can become cancerous. Currently, the standard treatment for patients with vulval intraepithelial neoplasia is surgery, but this approach does not guarantee cure and can be disfiguring, causing physical and psychological problems, particularly in women of reproductive ...
Trad Karim Sami - - 2014
The aim of this randomized, crossover study was to determine if transoral fundoplication (TF) could further improve clinical outcomes in partial responders to high-dose (HD) proton-pump inhibitor (PPI) therapy and to evaluate durability of TF. In seven United States centers, patients with hiatal hernia <=2 cm and abnormal esophageal acid ...
Kennedy N A NA Gastrointestinal Unit, Western General Hospital, Edinburgh, - - 2014
Thiopurines (azathioprine and mercaptopurine) remain integral to most medical strategies for maintaining remission in Crohn's disease (CD) and ulcerative colitis (UC). Indefinite use of these drugs is tempered by long-term risks. While clinical relapse is noted frequently following drug withdrawal, there are few published data on predictive factors. To investigate ...
Huttner Benedikt B VA Salt Lake City Health Care System, IDEAS Center, Salt Lake City, UT 84148, USA Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, - - 2014
To assess rates of starting or stopping antibiotics across different hospitals. We used barcode medication administration data to measure antibiotic use on acute-care wards in 128 Veterans Affairs medical centres (VAMCs) in 2010. A treatment day (TD) was defined as the administration of any antibiotic on a given day. A ...
Del Fresno M Rosa MR Pediatric Rheumatology Unit and - - 2014
Recurrent pericarditis is a troublesome complication of idiopathic acute pericarditis and occurs more frequently in pediatric patients after cardiac surgery (postpericardiotomy syndrome). Conventional treatment with nonsteroidal antiinflammatory drugs, corticosteroids, and colchicine is not always effective or may cause serious adverse effects. There is no consensus, however, on how to proceed ...
Reis Leonardo Oliveira LO Department of Urology, University of Campinas, Unicamp, Campinas, São Paulo, - - 2014
Purpose After a successful pyeloplasty at 3 to 6 months, the question remains whether children need a long follow-up. Methods The medical charts of patients with long-term follow-up (> 5 years), who underwent dismembered pyeloplasty for uretero-pelvic junction obstruction (UPJO) from May 1998 to May 2007, excluding those with bilateral UPJO, solitary ...
Ishikura Kenji K Department of Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan, - - 2014
To investigate the long-term outcome in children with frequently relapsing nephrotic syndrome (FRNS) we conducted a follow-up of a previous randomized controlled trial (RCT) 10 years after the initiation of the treatment protocol. We previously conducted an RCT on the efficacy of cyclosporine for treating children with FRNS. After 2 years of ...
Pereira Vitor Mendes VM Interventional Neuroradiology Unit, Service of Neuroradiology, University Hospitals of Geneva, Geneva, Switzerland Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, - - 2014
Flow diverter stents (FDS) have been described as a breakthrough in the treatment of intracranial aneurysms. Of the various flow diverter models, the Pipeline device has been the main approved and used device, with established and good long-term results. To present the first series of patients treated with its new ...
Tan Shu-Tao ST Department of Urology, Shengjing Hospital, China Medical University, China - - 2014
Bleeding stomal varices after ileal conduit urinary diversion are rare, but they can develop in patients with portal venous hypertension caused by cirrhosis. We report the case of a 68-year-old man who developed stomal haemorrhage two months after radical cystectomy and ileal conduit urinary diversion to treat invasive bladder cancer. ...
Batirel Ayse A Infectious Diseases and Clinical Microbiology, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Semsi Denizer Cd. E-5 Karayolu Cevizli Mevkii, 34890 Kartal, Istanbul, Turkey. Electronic address: - - 2014
To compare responses to tenofovir (TDF) and entecavir (ETV) therapy. This was a multicenter retrospective study including treatment-naïve patients with chronic hepatitis B (CHB) who received TDF or ETV. The primary end-points were undetectable HBV-DNA at 48 weeks and serological and biochemical responses. Out of 195 CHB patients, 90 (46%) ...
Maffi Paola P 1 Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy. 2 Department of Surgery, Cell Isolation and Transplantation Center, University of Geneva, Genève, Switzerland. 3 Department of Radiology and Center for Experimental Imaging, IRCCS San Raffaele Scientific Institute, Milan, Italy. 4 Vita-Salute San Raffaele University, Milan, Italy. 5 Correspondence to: Prof. Lorenzo Piemonti, MD, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Antonio Secchi, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, - - 2014
Our final objective is to develop an adoptive therapy with tolerogenic donor-specific type 1 T regulatory cells for patients with type 1 diabetes undergoing islet transplantation. The achievement of this objective depends on the availability of an immunosuppressive treatment compatible with the survival, function, and expansion of type 1 T ...
de Andrés-Nogales F F Pharmacoeconomics & Outcomes Research Iberia (PORIB), Pozuelo de Alarcón, Madrid, España. Electronic address: - - 2014
Oral anticoagulant therapy is complex due to the need for control and the hemorrhagic risk the therapy entails. This study aims to determine the standard clinical practice in the treatment for preventing stroke in patients with nonvalvular atrial fibrillation (NVAF) in Spain. The Real Evidence of Anti Coagulation Treatment in ...
Pradelli J J Infectiologie, Hôpital de l'Archet 1, Centre Hospitalier Universitaire de Nice, Université de Nice Sophia-Antipolis, BP 3079, 06202, Nice, - - 2014
Guidelines for inpatients with community-acquired pneumonia (CAP) propose to use respiratory fluoroquinolone (RFQ) and/or third-generation cephalosporins (Ceph-3). However, broad-spectrum antibiotic therapy is associated with the emergence of drug-resistant bacteria. We established a guideline in which RFQ and Ceph-3 were excluded as a first course. Our aim was to evaluate the ...
Ansari Julia G - - 2014
Atrial fibrillation affects approximately 5 million patients in the United States. The rate of stroke in adults with atrial fibrillation depending on their risk factors varies between 1-20% annually. Anticoagulation with vitamin K antagonists such as warfarin has been the mainstay therapy but it is cumbersome and requires close follow-up. ...
Silverman Steven H SH Department of Surgery, Florida State University Medical School, Sarasota, Fla. Electronic address: - - 2014
Renal artery in-stent restenosis (RAISR) is not an infrequent occurrence and may be in part responsible for the failure of renal stents to improve clinical outcome. A variety of treatments have been used to restore patency, with mixed results. These include repeated percutaneous transluminal renal angioplasty (PTRA), repeated PTRA with ...
Golden Matthew R MR From the *Center for AIDS and STD, University of Washington, Seattle, WA; and †Public Health-Seattle & King County, Seattle, - - 2014
US gonorrhea treatment guidelines recently changed to promote ceftriaxone as first-line therapy. Because ceftriaxone requires intramuscular administration, this could lead some patients to go untreated. We used an arithmetic model to compare the number of persons with gonorrhea who would be successfully treated with continued use of oral therapies versus ...
- - 2014
Surgery can present a management dilemma for gynecologists whose patients receive chronic antithrombotic therapy because the risk of hemorrhagic complications must be balanced against the risk of thromboembolic complications. Interruption of antithrombotic therapy to reduce perioperative bleeding poses a significant risk of recurrent thromboembolic events. Patients who receive chronic antithrombotic ...
Li Hui H Department Nephrology, The Xiangya Hospital of Central South University , Changsha, Hunan , China - - 2014
Abstract Objective: To investigate the treatment efficacy of adefovir dipivoxil combined with a corticosteroid on hepatitis B virus-associated glomerulonephritis (HBV-GN). A total of 38 patients with nephrotic syndrome induced by HBV-GN were treated for 36 weeks between 2010 and 2012. The efficacy analysis showed that 11 patients achieved complete remission ...
Pourmand Gholamreza G Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, - - 2014
To evaluate if addition of l-carnitine therapy to standard varicocelectomy adds any extra benefit in terms of improvement in semen parameters or deoxyribonucleic acid (DNA) damage. One hundred patients enrolled in this study and were randomly divided into 2 groups (50 patients in each group). In group 1, standard inguinal ...
Liu Xiangdong X Department of Ophthalmology, Jinshan Hospital, Fudan University, Shanghai 201508, - - 2014
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) drugs and corticosteroids are being widely used to treat diabetic macular edema (DME). The purpose of this study was to evaluate further the efficacy and safety of intravitreal bevacizumab (IVB) alone in comparison with intravitreal bevacizumab combined with triamcinolone acetonide (IVB/IVT) in the treatment ...
Greig Sarah L SL Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand, - - 2014
Dabigatran etexilate (Pradaxa(®), Prazaxa(®)) has recently been approved for the treatment of acute venous thromboembolism (VTE) and prevention of VTE recurrence. Dabigatran etexilate is an oral prodrug of dabigatran, a selective, reversible, competitive, direct thrombin inhibitor. Dabigatran etexilate has a wide therapeutic range that allows for fixed-dose administration without the ...
Jones Randolph Todd C RT New York University, NYU Vein Center, 530 1st Avenue, New York, NY 10016 USA. - - 2014
Fifteen years ago, radiofrequency ablation of the saphenous vein was introduced as a new and minimally invasive modality for the treatment of superficial venous insufficiency. Three years later, it was followed by endovenous laser ablation. These procedures have revolutionized the treatment of superficial venous insufficiency and have caused a dramatic ...
Barton Andrea L AL Department of Pharmacy, Texas Children's Hospital, Houston, - - 2014
To report our experience with high-dose propranolol monotherapy for prophylaxis and treatment of infant supraventricular arrhythmias (SAs). Patients <1 year of age initiated on enteral propranolol as inpatients for management of SA were identified during a 10-year time period from the Texas Children's Hospital pharmacy database. Patients were included if they ...
Michalewski Janusz J Ophthalmic Clinic Jasne Blonia, Rojna 90, Lodz, Poland; Third Municipal Hospital, K. Jonscher, Milionowa 14, Lodz, - - 2014
This study aimed to report on the efficacy of 1 dose of aflibercept in bevacizumab nonresponders. This was a retrospective, single-centre, interventional, noncomparative study. This study retrospectively analyzed 23 patients with persistent intraretinal or subretinal fluid treated with 6 or more monthly bevacizumab injections. Patients were switched to 1 dose ...
Sedal L L Neuroimmunology Clinic, Clinical Neurosciences, St Vincent's Hospital Melbourne, Melbourne, Victoria, - - 2014
Multiple sclerosis was without effective disease-modifying therapy for many years. The introduction of the injectable therapies (interferon and glatiramer acetate) some 20 years ago was considered a major advance. Recent years have heralded a revolution in treatment options with the introduction of intravenous natalizumab and, even more recently, three oral ...
Ehsani Amir Hooshang AH Razi Hospital, Tehran University of Medical Sciences, Tehran, - - 2014
The combination of pulsed dye laser (PDL) and topical propranolol are used with variable effectiveness for the treatment of infantile hemangiomas (IH), particularly for superficial lesions. The aim of this study was to investigate whether the therapeutic efficacy of prescribing topical propranolol along with PDL was superior to PDL therapy ...
Westendorp Willeke F - - 2014
Infections occur in 30% of stroke patients and are associated with unfavorable outcomes. Preventive antibiotic therapy lowers the infection rate after stroke, but the effect of preventive antibiotic treatment on functional outcome in patients with stroke is unknown. The PASS is a multicenter, prospective, phase three, randomized, open-label, blinded end-point ...
Patel Anup A New Haven and Hartford, Conn.; Charlottesville, Va.; Pittsburgh, Pa.; and DeKalb, Ill. From the Section of Plastic and Reconstructive Surgery, Yale University School of Medicine; the Craniofacial Surgery Center, Connecticut Children's Medical Center; the Department of Neurosurgery, University of Virginia School of Medicine; the University of Pittsburgh School of Medicine; and the Department of Psychology, Northern Illinois - - 2014
The relationship between surgical age and long-term neuropsychological outcomes in sagittal-suture craniosynostosis remains equivocal. Whole-vault cranioplasty and strip craniectomy are performed at various times in individuals with sagittal-suture craniosynostosis. This study used comprehensive neurological testing to examine the relationship between age at time of surgery and long-term neuropsychological function. Seventy ...
Hosseini Vahid V Inflammatory Diseases of the Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari, - - 2014
BACKGROUND Furazolidone has been used as an alternative for clarithromycin or metronidazole in Helicobacterpylori (H.pylori) eradication regimens. In Iran, 14-day Furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. Therefore, we designed a study to compare the efficacy of two 10-day triple regimens ...
Fang Yu-Qing YQ Centre for Liver Diseases and Department of Infectious Diseases (Y-QF, WJ, JL, Y-QD, YW, MY, G-QW), Peking University First Hospital, Xicheng District, Beijing; and Department of Infectious Diseases (D-XL), Sixth Hospital of Shenyang, Heping District, Shenyang, Liaoning, - - 2014
To the best of our knowledge, this is the first study to address the use of glucocorticoids in the comparatively special population of pure primary biliary cirrhosis (PBC) patients who have high levels of immunoglobulin G (IgG) and transaminases but do not have PBC-autoimmune hepatitis overlap syndrome. Ursodeoxycholic acid (UDCA) ...
Kim Sung Han SH Department of Neurosurgery, Gangnam Severance Hospital, The Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, - - 2014
To analyze the clinical courses and outcomes after anterior lumbar interbody fusion (ALIF) for the treatment of postoperative spondylodiscitis. A total of 13 consecutive patients with postoperative spondylodiscitis treated with ALIF at our institute from January, 1994 to August, 2013 were included (92.3% male, mean age 54.5 years old). The ...
Nair Velu V Dean & Deputy Commandant, Armed Forces Medical College, Pune 411040, - - 2014
The BCR-ABL tyrosine kinase is a well validated therapeutic target in Chronic Myeloid Leukemia (CML). Imatinib mesylate (IM), a tyrosine kinase inhibitor is highly effective in the treatment of chronic phase CML. BCR - ABL transcripts have been well established as a molecular marker to document response to therapy in ...
Zhu Hui H Department of Dermatology, Second Hospital of Tianjin Medical University, Tianjin, - - 2014
Pseudoepitheliomatous, keratotic, and micaceous balanitis (PKMB) is an extremely rare condition occurring over the glans in older men who undergo circumcision late in life. Its exact etiology is unknown. We report a patient with PKMB that involved the meatus and led to urinary obstruction. A 57-year-old, circumcised man presented with ...
Muram David D Lilly USA, LLC, Indianapolis, IN, - - 2014
Patterns of care following topical testosterone agent (TTA) initiation are poorly understood. This study aimed to characterize care following TTA initiation and compare results between patients with and without a serum testosterone (T) assay within 30 days before and including TTA initiation. Adult men (N = 4,146) initiating TTAs from ...
Hokari Masaaki M Department of Neurosurgery, Kushiro Rousai Hospital, Kushiro-shi, Hokkaido, Japan. Electronic address: - - 2014
Since the introduction of carotid stenting (CAS), a combined treatment for bilateral lesions using carotid endarterectomy (CEA) and CAS has been developed. However, there has been only 1 report about CEA then CAS. Herein we describe 2 patients with bilateral severe carotid stenosis who were treated by CEA for the ...
Omrani Ali S AS Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Saudi - - 2014
Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with high mortality and has no approved antiviral therapy. We aimed to compare ribavirin and interferon alfa-2a treatment for patients with severe MERS-CoV infection with a supportive therapy only. In this retrospective cohort study, we included adults (aged ≥16 years) with ...
Hamzeh Nabeel N Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver, CO, USA; Division of Pulmonary and Critical Care Sciences, Department of Medicine, University of Colorado, Aurora, CO, USA. Electronic address: - - 2014
Immunosuppressive (IS) therapy is indicated to treat progressive sarcoidosis, but randomized controlled trials to guide physicians in the use of steroid sparing agents are lacking. The aim of this retrospective study was to examine the role of mycophenolate mofetil (MMF) as an alternative therapy in the treatment of sarcoidosis. A ...
Galanis Taki T Department of Surgery, Jefferson Vascular Center, Jefferson Medical College, Thomas Jefferson University Hospitals, Philadelphia, - - 2014
Several novel oral anticoagulants have been studied for the prevention and treatment of venous thromboembolism (VTE) in different patient populations. Clinicians will increasingly encounter scenarios in which they must choose among these and conventional anticoagulants for the treatment of this potentially fatal condition. To review the results of Phase III ...
DeWitt Elizabeth S ES Department of Cardiology; Boston Children's Hospital & Department of Pediatrics, Harvard Medical School, Boston, - - 2014
-Implantable cardioverter-defibrillators (ICDs) used to prevent sudden cardiac arrest in children provide appropriate therapy in 25% of patients, but also result in a significant incidence of inappropriate shocks and other device complications. ICDs placed for secondary prevention have higher rates of appropriate therapy than those placed for primary prevention. Pediatric ...
Bonnet Delphine D Delphine Bonnet, Matthieu Guivarch, Anaïs Palacin, Laurent Alric, Internal Medicine-Digestive Department, Purpan University Hospital, 31059 Toulouse cedex 9, - - 2014
To assess, in a routine practice setting, the sustained virologic response (SVR) to telaprevir (TPV) or boceprevir (BOC) in hepatitis C virus (HCV) null-responders or relapsers with severe liver fibrosis. One hundred twenty-five patients were treated prospectively for 48 wk with TPV or BOC + pegylated-interferon (peg-INF) α2a + ribavirin ...
Glatz Andrew C AC Divisions of Cardiology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of - - 2014
Objectives: To describe the results of a clinical practice pathway (CPP) for the management of post-catheterization pulse loss in a children's hospital. Background: Standardized approaches to the diagnosis and management of post-catheterization arterial thrombus are lacking. As a result, substantial practice variation exists. Methods: Data collected prospectively for QI purposes ...
Ho M M Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, Hong - - 2014
AimTo report the visual outcome of polypoidal choroidal vasculopathy receiving combined treatment with photodynamic therapy using Visudyne and intravitreal ranibizumab injections, and to analyze the predictive factors of visual outcome at 1 year post treatment.MethodsSeventy-four consecutive patients with newly diagnosed polypoidal choroidal vasculopathy were treated with photodynamic therapy using Visudyne ...
Korkmaz Serdal S Division of Hematology, Kayseri Education and Research Hospital, Kayseri, - - 2014
We aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (TKI) therapy. Data including the clinical characteristics, therapeutic outcomes and compliance with TKI therapy of ...
Collins Peter W PW Arthur Bloom Haemophilia Centre, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom; - - 2014
This multinational, randomized, single-blind trial (NCT01333111 [www.clinicaltrials.gov]) investigated safety and efficacy of nonacog beta pegol, a recombinant glycoPEGylated factor IX (FIX) with extended half-life, in 74 previously treated hemophilia B patients (FIX activity ≤2 IU/dL). Patients received prophylaxis for 52 weeks, randomized to 10 IU/kg or 40 IU/kg once weekly, ...
Melo Mônica de Oliveira MD Exercise Research Laboratory, Federal University of Rio Grande do Sul, Porto Alegre, Brazil Núcleo de Pesquisa em Ciências e Arte do Movimento Humano, University of Caxias do Sul, Caxias do Sul, Brazil - - 2014
To determine the effects of low-level laser therapy in combination with neuromuscular electrical stimulation on the muscle architecture and functional capacity of elderly patients with knee osteoarthritis. A randomized, evaluator-blinded clinical trial with sequential allocation of patients to three different treatment groups. Exercise Research Laboratory. A total of 45 elderly ...
Pavone Vito V Department of Orthopedics, Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele, Catania, - - 2014
Developmental dysplasia of the hip is an anomaly of the hip joint. In patients with early diagnosis, within 3 to 6 months of life, the treatment is essentially conservative and involves the use of dynamic harness. The indication for the use of the Tubingen hip flexion splint is a dysplastic ...
Hägi Tobias T - - 2014
Objectives: To characterize the physical characteristics of a new low abrasive erythritol powder (EPAP) and to evaluate its influence on the clinical and microbiologic parameters over a period of 6 months in patients undergoing supportive periodontal therapy (SPT). Method and Materials: Prior to the clinical application, the particle size and ...
Simon J-C JC Department of Dermatology, Venereology and Allergology, University of Leipzig Medical Center, Leipzig, - - 2014
Actinic keratoses (AKs) are clinically significant and require therapy. Efficacy of low-dose (0.5%) 5-fluorouracil with 10% salicylic acid (5-FU/SA) has been shown in randomized comparative trials of hyperkeratotic lesions of various grades. To evaluate the efficacy, tolerability and safety of low-dose 5-FU/SA topical solution vs. cryosurgery in patients with moderate/severe ...
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