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Shetty Vanaja P - - 2011
Sixty two patients with relapsed leprosy seen between Jan 2004 and Dec 2009 were studied using clinical, bacteriological and histopathological parameters. The findings thus obtained were correlated to parameters such as trend and source of referral, clinical characteristics at diagnosis, treatment received, other events during or after RFT and duration ...
Karanikolas George N - - 2011
To assess the efficacy and safety of adalimumab or cyclosporine (CYC) as monotherapy or combination therapy for patients with active psoriatic arthritis (PsA), despite methotrexate (MTX) therapy. A prospective 12-month, nonrandomized, unblinded clinical trial of 57, 58, and 55 patients who received CYC (2.5-3.75 mg/kg/day), adalimumab (40 mg every other ...
Gupta Ramji - - 2011
Treatment of plantar warts caused by human papilloma virus (HPV) strain types 1, 2 and 4 is often difficult and a challenging problem. Various therapeutic modalities available for treating this problem have not been uniformly successful. The purpose of present study is to evaluate the efficacy of adapalene applied locally ...
Chi Byung Hoon - - 2011
Sexual adverse events (AEs), a major cause for discontinuing 5α-reductase inhibitor (5ARI) therapy for benign prostatic hyperplasia (BPH), are known to occur most frequently early in therapy and appear to decline over time. The aim of this study was to investigate the changes in sexual function occurring with dutasteride treatment ...
Frega Antonio - - 2011
VIN usual type appears to be related to the HPV's oncogenic types. The aim of this prospective multicenter study was to evaluate the re-infection rate of high-risk HPV and the recurrence rate of VIN usual type after surgical treatment. The study enrolled 103 women affected by VIN usual type. They ...
Małgorzata Figurska - - 2011
The aim of this paper was to evaluate functional and anatomical results of intravitreal ranibizumab injections and the course of exudative age-related macular degeneration (AMD) treatment over a 12-month observation period. In 25 patients with active dominantly classic exudative AMD, treatment was performed according to the following schedule: 3 intravitreal ...
Lustenberger David P - - 2011
Trochanteric bursitis (TB) is a self-limiting disorder in the majority of patients and typically responds to conservative measures. However, multiple courses of nonoperative treatment or surgical intervention may be necessary in refractory cases. The purpose of this systematic review was to evaluate the efficacy of the treatment of TB. A ...
Karatapanis S - - 2011
Increasing data suggests that the efficiency of standard triple therapies of 7-10-14 days duration has fallen below the threshold for acceptability (80% cure rates in intention to treat analysis). Use of rabeprazole, a PPI less influenced by CYP2C19 gene polymorphisms is reported to lead to improved eradication rates. This study ...
Amr Yasser Mohamed YM Anesthesia Department, Tanta University Hospital, Tanta, Egypt. - - 2011
Treating sciatica with epidural steroid injection has been a common practice worldwide. N-methyl-D-aspartate (NMDA) receptors are an important component of pain pathways. The aim of this study was to evaluate the safety and efficacy of epidurally administered NMDA receptor antagonists (ketamine) for the treatment of chronic low back pain secondary ...
Hurtuk Agnes M - - 2011
Objective. To report long-term, health-related quality-of-life (HRQOL) outcomes in patients treated with transoral robotic surgery (TORS).Study Design. Prospective, longitudinal, clinical study on functional and HRQOL outcomes in TORS.Setting. University tertiary care facility.Subjects and Methods. Patients who underwent TORS were asked to complete a Head and Neck Cancer Inventory before treatment ...
Kane Sunanda V - - 2011
BACKGROUND: Patients receiving 5-aminosalicylic acid (5-ASA) require long-term therapy to achieve good outcomes. Persistency (duration of time from initiation to discontinuation of therapy) is therefore an important consideration. AIM: To evaluate persistency in patients receiving various oral 5-ASA formulations. METHODS: This retrospective, 12-month, cohort study examined new-starter patients (any age ...
Kwan Patrick P Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China. - - 2011
Efficacious and safe monotherapy options are needed for adult patients with newly diagnosed epilepsy. As an adjunctive treatment for partial seizures, pregabalin compares favourably with lamotrigine and is an effective, approved treatment. We studied the efficacy and safety of pregabalin as monotherapy, using a design that complied with European regulatory ...
Kostecki Jacek - - 2011
OBJECTIVE: In this study, the mid-term results (6 month follow-up) of the endovascular treatment in patients with Chronic Cerebro-Spinal Venous Insufficiency (CCSVI) and multiple sclerosis (MS) were prospectively evaluated. METHODS: Thirty-six patients with confirmed MS and CCSVI underwent endovascular treatment by the means of the uni- or bilateral jugular vein ...
Mutschler Jochen - - 2011
OBJECTIVES:: Disulfiram is effective in relapse prevention in alcoholism. However, the optimal therapeutic aftercare regimen for patients is still unclear, and disulfiram is associated with numerous adverse events. Also, it is not clear if supervised long-term disulfiram treatment is safe and sufficiently efficient in the long run. METHODS:: We evaluated ...
Koh Kyoung Hwan - - 2011
BACKGROUND: Some studies have shown that rotator cuff tendon (RCT) retears occur early after surgery and ultimate failure strength is reached at between 3 and 6 months. However, few clinical studies have been reported to support their theory. The purpose of this study was to determine whether the RCT integrity ...
Thrumurthy S G - - 2011
The role of Thoracic Endovascular Repair (TEVAR) in chronic type B aortic dissection remains controversial and its mid-term success as an alternative to open repair or best medical therapy remains unknown. The aim of the present study was to provide a systematic review of mid-term outcomes of TEVAR for chronic ...
Snider Kenneth R - - 2011
To evaluate the use of budesonide for the treatment of autoimmune hepatitis (AIH). Literature was accessed through PubMed/MEDLINE (1966-June 2011) and Web of Science (1965-June 2011) using the terms autoimmune hepatitis and budesonide. Literature was limited to English-language publications. In addition, references from publications identified were reviewed. All articles in ...
Doss Brian D - - 2011
Premature termination (PT) has been identified as widespread in individual, family, and couple therapy. Unfortunately, research on PT utilizes numerous definitions of PT without providing guidance on which definition may be most clinically useful. The current study investigated seven definitions of PT (three based on therapist ratings and four based ...
Qiu Haixia - - 2011
BACKGROUND Port wine stains (PWS) are congenital capillary malformations of the skin and are difficult to treat without scarring. Since January 1991, our group has performed a new modality of vascular-targeted photodynamic therapy (PDT) for PWS treatment. OBJECTIVE To summarize our clinical experiences with vascular-targeted PDT for PWS at Chinese ...
Turgeon Alexis F - - 2011
Severe traumatic brain injury often leads to death from withdrawal of life-sustaining therapy, although prognosis is difficult to determine. To evaluate variation in mortality following the withdrawal of life-sustaining therapy and hospital mortality in patients with critical illness and severe traumatic brain injury, we conducted a two-year multicentre retrospective cohort ...
Makdoumi Karim - - 2012
The aim of this work as to investigate the photochemical interaction used in corneal crosslinking (CXL) as the primary therapy for bacterial keratitis. A prospective non-randomized study was conducted including 16 patients with a clinical diagnosis of bacterial keratitis. No patient had any prior antibiotic treatment for the current infection. ...
Borowitz Drucy - - 2011
OBJECTIVES:: Patients with cystic fibrosis (CF) who have exocrine pancreatic insufficiency (EPI) require treatment with pancreatic enzyme replacement therapy (PERT) to maintain adequate nutrition and age-appropriate growth and weight gain. Liprotamase, a non-porcine, highly purified biotechnology-derived PERT has demonstrated significant efficacy in fat and protein malabsorption in EPI patients compared ...
Chitnis Shilpa - - 2011
ABSTRACT Background: When rotigotine patch was withdrawn from the US market, we prospectively gathered data on efficacy, side effects, and daytime sedation on patients while taking rotigotine and following the switch to alternate therapies. Methods: Patients rated the efficacy of rotigotine on a scale of 0-5 (ineffective to extremely effective) ...
Patel Atul T - - 2011
BACKGROUND AND PURPOSE:/b>Poststroke spasticity often negatively affects functional activities and daily living and frequently is accompanied by pain, abnormal limb postures, and contractures. The purpose of this case report is to describe the long-term benefit of botulinum toxin A in a patient with poststroke spasticity. CASE DESCRIPTION: /b>A 35-year-old woman ...
Lozoya-González Diego - - 2011
BACKGROUND: The American Society for Gastrointestinal Endoscopy (ASGE) has published recommendations in regards to anticoagulant (AC) and antiplatelet (AP) therapy management during endoscopic procedures. So far, no study has assessed either ASGE recommendation compliance during percutaneous endoscopic gastrostomy (PEG) placement or procedure-associated complication rates as related to the observance of ...
Lee Joo Yong - - 2011
This prospective study evaluated the safety of tadalafil 5 mg taken once a day (OAD) in terms of hypotensive side effects and whether it improves lower urinary tract symptoms (LUTS) and restores sexual function in patients with erectile dysfunction (ED) who are receiving concomitant α-blocker (AB) therapy for benign prostatic ...
Cohen Meryl D - - 2011
BACKGROUND AND PURPOSE:/b>This case report describes a patient who developed lower-extremity lymphedema secondary to orthopedic trauma and surgery and reports the response to complete decongestive physical therapy (CDP), with 8 treatment sessions over 3 months. CASE DESCRIPTION: /b>The patient was a 56-year-old man who sustained a right ankle displaced fibular ...
Knekt Paul - - 2011
BACKGROUND: The need for treatment is, despite of its obvious usefulness, a scarcely used measure of effectiveness in psychotherapy trials. This study considers changes in the need for auxiliary psychiatric treatment after starting short- and long-term psychotherapy and psychoanalysis. METHODS: Altogether 326 psychiatric outpatients with mood or anxiety disorder were ...
Lorente-Velázquez Amalia - - 2011
PURPOSE.: To compare intraocular straylight and contrast sensitivity determined before corneal refractive therapy and after 15 days and 1 month of treatment. METHODS.: A single-center, prospective, and longitudinal study was performed in 30 subjects undergoing corneal refractive therapy. In each subject, high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA), straylight, ...
Kinsella Janette J Urology Centre, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, Great Maze Pond, London, UK. - - 2012
To determine whether preoperative demonstrations of intracavernosal and vacuum therapies for erectile dysfunction (ED) influence the decision of treatment choice, reducing long-term regret. In all, 82 consecutive men with localized prostate cancer, scheduled for radical prostatectomy and reporting an International Index of Erectile Function score of >21, were prospectively enrolled ...
Eerenberg Elise S - - 2011
Abstract Vitamin K antagonists (VKA) are the only registered oral anticoagulants for the treatment of venous thromboembolism (VTE). VKA have an unpredictable and highly variable effect on coagulation, with a high risk of under- and over-treatment. Novel anticoagulants, such as dabigatran and rivaroxaban, could be a very welcome replacement for ...
Benedik-Dolničar M - - 2011
Background:  Gaucher disease type 1 (GD1) was the first lysosomal storage disorder for which an effective enzyme replacement therapy, was developed. We describe the management of eight GD1 patients in Slovenia who were diagnosed between the ages of 2 to 15 years. Methods:  Patients were individually assessed to establish initial ...
Ong A - - 2011
In chronic hepatitis B (CHB) patients, adefovir is commonly used as a rescue therapy for lamivudine resistance, but often results in incomplete virological suppression. To study the factors predicting response to adefovir rescue, and the treatment response of tenofovir and entecavir in suboptimal responders to adefovir in CHB patients. Chronic ...
Kiss L S - - 2011
Adalimumab is a fully human monoclonal antibody targeting tumour necrosis factor with proven efficacy in the treatment of Crohn's disease (CD). To investigate the predictors of medium-term clinical efficacy and mucosal healing during adalimumab therapy, in patients with CD, in specialised centres approved for biological therapy in Hungary. Data capture ...
Harrison Daniel M - - 2012
Previous studies have described stabilization of aggressive multiple sclerosis (MS) with one-time induction therapy with high-dose cyclophosphamide (HiCy). The long-term benefit of this stabilization followed by conventional therapy has not been explored. The objective of this study was to evaluate the safety and clinical outcomes following treatment of relapsing-remitting MS ...
Eastell Richard - - 2011
Determining how quickly bisphosphonate treatment effects begin to regress is crucial when considering termination of treatment. Our objective was to assess the effects of 1 yr discontinuation of risedronate use in postmenopausal women with osteoporosis who had previously received risedronate for 2 or 7 yr. Before initiation of the current ...
Dennis Madison M University of Toronto, School of Medicine, Toronto, ON, - - 2013
The Goeckerman regimen, consisting of the application of crude coal tar combined with exposure to ultraviolet radiation, was formulated in 1925 for the treatment of psoriasis. While some centers have adapted the Goeckerman regimen for the treatment of eczema, there are no published reports of its efficacy in this condition. ...
Bates David - - 2011
Natalizumab treatment significantly reduced the annualised relapse rate and MRI activity over 2&emsp14;years compared with placebo in phase III trials when administered as monotherapy in AFFIRM or in combination with interferon β-1a (IFNβ) in SENTINEL. The post hoc analyses reported here sought to determine the effect of natalizumab treatment on ...
Mabrouk Dalia - - 2011
  Pemphigus vulgaris (PV) is a rare, potentially fatal chronic autoimmune disease of the skin and mucous membrane. The objective of this study was to analyze the clinical outcomes and side effects associated with treatment of childhood PV (CPV). A retrospective review of the English language literature was conducted through ...
Lee Seung Ah - - 2011
The age distribution of breast cancer patients in Korea, where most are less than 60 years of age and have recently entered menopause, differs from that in the West. The aim of this study was to evaluate bone mineral density (BMD) changes in Korean breast cancer patients treated with an aromatase ...
Bodar E J - - 2011
BACKGROUND: Mevalonate kinase deficiency (MKD) is a hereditary autoinflammatory syndrome marked by recurrent attacks of fever and inflammation. Severe enzyme deficiency results in mevalonic aciduria (MA) and milder deficiency in hyperimmunoglobulin D syndrome (HIDS). Treatment remains a challenge. OBJECTIVE: To observe the effect of the recombinant interleukin-1 receptor antagonist anakinra ...
Flaxel Christina - - 2011
PURPOSE:: To evaluate whether bromfenac eyedrops and ranibizumab intravitreal injections would provide added efficacy over ranibizumab alone. METHODS:: This was a single-site, multiinvestigator, prospective, open-label, interventional, Phase II study of patients with new or recurrent exudative/neovascular age-related macular degeneration. Thirty eyes were enrolled consecutively and were randomized in a ratio ...
Coskunseven Efekan - - 2011
PURPOSE:To present visual and refractive outcomes in 11 eyes that underwent femtosecond LASIK and subsequent retreatment with flap lifting using only side cutting. METHODS:Seven patients (11 eyes) with a mean age of 30.55±5.42 years (range: 24 to 39 years) underwent retreatment 18.18±5.41 months (range: 12 to 26 months) after primary ...
Vlastarakos Petros V - - 2011
Over 60 years since its first report, sudden sensorineural hearing loss (SSNHL) still represents an ill-explained condition, with potentially devastating effects for the quality of life of previously well patients. The present study critically reviewed the available evidence regarding the efficacy of intra-tympanic steroid administration in the treatment of SSNHL. Factors ...
Kassem Riad - - 2011
BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disease that can significantly affect the patient's quality of life. OBJECTIVE: We sought to demonstrate the therapeutic efficacy of local ultraviolet (UV) B phototherapy in OLP. METHODS: Patients with biopsy-confirmed erosive OLP recalcitrant to previous medical therapy were treated with the ...
Feldmeyer Laurence - - 2011
Background: Erythroplasia of Queyrat (EQ) is an intra-epithelial carcinoma of the penis. Progression to invasive carcinoma may occur. Its cause is unknown but some evidence suggests infection with human papillomavirus in the pathogenesis of EQ; however, recent data do not confirm this. Therapy is difficult and associated with important recurrence ...
Sakamoto F H - - 2011
Background:  Photodynamic therapy (PDT) is a non-surgical alternative to conventional tumour excision for non-melanoma skin cancers (NMSC). Objective:  We evaluated whether patients with field cancerization (multiple NMSC) treated with aminolevulinic acid (ALA) or methyl-ester of ALA (MAL) for that indication had PDT-induced changes in surgical scars in the treatment field. ...
Katzka D A - - 2011
Background  Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up. Aim  To summarise and analyse 29 available studies evaluating pneumatic dilation for achalasia with focus on efficacy, rate or ...
Waiser Johannes - - 2011
BACKGROUND: Antibody-mediated rejection (ABMR) following kidney transplantation is associated with poor allograft survival. Conventional treatment based on plasmapheresis (PPH) and the administration of intravenous immunoglobulins (IVIG) is not satisfactory. Two compounds, more specifically targeting B cells and plasma cells, may help to improve the prognosis: rituximab, a B-cell-depleting monoclonal antibody, ...
Maruko Ichiro - - 2011
PURPOSE: To retrospectively evaluate choroidal thickness 1 year after photodynamic therapy in eyes with central serous chorioretinopathy using optical coherence tomography. METHODS: Central serous chorioretinopathy was diagnosed using fluorescein angiography, and indocyanine green angiography was used to evaluate choroidal vascular hyperpermeability. We measured the subfoveal choroidal thickness using enhanced depth ...
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