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Shami Paul J - - 2012
With the development of tyrosine kinase inhibitors (TKIs), the management and outlook for patients with chronic myelogenous leukemia (CML) have completely changed over the past 10 years. Imatinib was the first TKI approved to treat CML in the chronic phase. After their initial approval as second-line agents, dasatinib and nilotinib ...
Dai Wei-Qi - - 2012
This study aimed to compare the 7d triple therapy with 3d and 5d triple therapies, to observe the effect of eradicating Helicobacter pylori (Hp) on treating duodenal ulcers. One hundred and sixteen patients who were confirmed duodenal ulcer active period and Hp positive were enrolled in the study. All the ...
Utrilla-Rodríguez Elia María - - 2012
: To evaluate the efficacy of a modified Copenhagen physical therapy method in reducing surgery rates for congenital idiopathic clubfoot. : This research is a retrospective descriptive study of 82 patients (123 clubfeet). All patients were younger than 2 months at the beginning of the treatment and were initially evaluated ...
Akaishi Satoshi - - 2012
Pathological cutaneous scars such as keloids and hypertrophic scars (HSs) are characterized by a diffuse redness that is caused by the overgrowth of capillary vessels due to chronic inflammation. Our group has been using long-pulsed, 1064-nm Nd:YAG laser in noncontact mode with low fluence and a submillisecond pulse duration to ...
Chu Alice - - 2012
The Ponseti method of clubfoot correction is now widely practiced worldwide. Initial correction rates are nearly 100%, but subsequent relapses may occur in up to one-third of patients. Very little has been written by anyone other than Dr Ponseti about the characterization and treatment of recurrent clubfoot deformity following use ...
Gupta Divya - - 2012
Depigmentation therapy in vitiligo is an option in those with extensive vitiligo who have failed to respond to medical therapy and have obvious cosmetic disfigurement due to intervening patchy pigmented areas. Various aspects of this therapy such as the cost, treatment time, course, permanency of depigmentation, side effects, and the ...
Batra Ruchika - - 2012
We sought to evaluate the efficacy of topical 3% diclofenac gel in the management of periocular actinic keratosis. Four consecutive patients with periocular actinic keratosis who were treated with topical 3% diclofenac gel twice daily for up to 4 months were included in the study. Patients were reviewed at 1 ...
Sugawara Junji - - 2012
Despite the known influence of early treatment on the facial appearance of growing patients with skeletal Class III malocclusion, few comparative reports on the long-term effects of different treatment regimens (1-phase vs 2-phase treatment) have been published. Uncertainty remains regarding the effects of early intervention on jaw growth and its ...
Pietrzak Radosław - - 2012
Background and aim: To analyse selected electrocardiographic (ECG) parameters in children after correction of tetralogy of Fallot (TOF). Methods: The study group consisted of 65 patients with surgically corrected TOF aged 6 to 18 years, and the time since surgical correction ranged from 6 to 18 years. The patients were ...
Bogner Johannes R - - 2012
Non-nucleoside antiretroviral combination therapy is the standard of care with a robust virologic efficacy and a good safety profile. One of the most frequently used non-nucleosides, nevirapine (NVP), has been available as a every 12 h, immediate-release (IR) tablet since 1996. In order to enhance convenience and adherence, a new ...
Hassan Megahed M - - 2012
To evaluate the long-term efficacy of arytenoid adduction (AA) combined with ansa cervicalis-recurrent laryngeal nerve anastomosis (ACN-RLN) in the treatment of unilateral vocal fold paralysis. Retrospective review of clinical records. Institutional practice. Nine patients with severe paralytic dysphonia with large glottal gap were included. Voice outcome was followed up over ...
Oida Takatsugu - - 2012
Background/Aims: The management of peptic ulcers has dramatically changed and the incidence of elective surgery for gastroduodenal peptic ulcers has markedly decreased; hence, the incidence of emergency surgery for perforated peptic ulcers has slightly increased. In select cases, conservative therapy can be used as an alternative for treating perforated gastroduodenal ...
Aydogan Kenan - - 2012
Background  Chronic ordinary urticaria (COU) can severely reduce quality of life and be difficult to control. Ultraviolet (UV) A and UVB phototherapy has been reported to decrease the release of histamine from either mast cells and/or basophils. Previous small studies have suggested that UVB phototherapy is a good alternative treatment ...
Haag-Weber Marianne - - 2012
Background: HX575 is a biosimilar version of epoetin-α that is approved for the treatment of anemia associated with chronic kidney disease (CKD) using the intravenous route of administration. Here we report data from a study of anemic pre-dialysis patients to assess the safety, immunogenicity and efficacy of subcutaneous (s.c.) administration ...
Yagci Ayse - - 2012
To report the long-term results of tarsal margin rotation with extended posterior lamellae advancement in the management of cicatricial entropion, trichiasis, and accompanying misdirected metaplastic lashes of the upper eyelid due to trachoma. Tarsal margin rotation and extended advancement of posterior lamellae were performed in 27 eyelids of 15 consecutive ...
Froissart Antoine - - 2012
To assess the efficacy and safety of rituximab in adults responding poorly to standard treatment for severe autoimmune thrombotic thrombocytopenic purpura. Open-label prospective study. Outcomes in the survivors were compared to those of 53 historical survivors who were given therapeutic plasma exchange alone or with vincristine. Hospitals belonging to the ...
Stefanou Amalia - - 2012
We designed a prospective, randomized study to evaluate the effects of iontophoresis delivery of dexamethasone versus corticosteroid injection therapy on patient outcomes. We randomized 82 patients to 10 mg dexamethasone via iontophoresis using a self-contained patch with a 24-hour battery; 10 mg dexamethasone injection; or 10 mg triamcinolone injection. All ...
Shea Paul F - - 2012
To evaluate the hearing changes and quality-of-life outcomes of 393 cases of streptomycin/dexamethasone inner ear perfusion performed by the primary author on 312 ears of 299 patients with Meniere's disease between July 2002 and May 2010. Retrospective chart review. Objective arm: A database was used to compile pretreatment and post-treatment ...
Ferenci P - - 2012
Summary.  The rapidity of viral disappearance on antiviral treatment of chronic hepatitis C with peginterferon/ribavirin correlates with the cure rate. The earlier the virus becomes undetectable, the higher are the response rates. This observation is the basis of response-guided therapy. Viral clearance within the first 4 weeks of treatment is ...
Miyamoto Hidenori - - 2012
Background/Aims: Aluminum potassium sulfate and tannic acid (ALTA) is a new sclerosing therapy for internal hemorrhoids. This injection therapy is a four-step direct injection sclerosing procedure intended to shrink and harden internal hemorrhoids to eliminate hemorrhoidal prolapse and bleeding. The aim of this study was to assess the short term ...
Hodgkinson J A - - 2012
Although there has been growing concordance over what constitutes best practice in recent guidelines for treatment of atrial fibrillation (AF), notably regarding anticoagulant use, it remains unclear whether patients are being treated accordingly. The aims of this study were to explore the pattern of treatment pathways - i.e. how patients ...
Tong Guang-Dong - - 2012
To observe the efficacy of ursodeoxycholic acid (UDCA) combined with Tongdan: Decoction () on immunological indices and histopathological changes in patients with primary biliary cirrhosis (PBC) of IIor III histological stage. Sixty PBC patients were assigned randomly and equally: to the control group treated with UDCA alone and the treatment ...
Pessôa Mario G - - 2012
A large number of patients with chronic hepatitis C have not been cured with interferon-based therapy. Therefore, we evaluated the efficacy of amantadine combined with the standard of care(pegylated interferon plus ribavirin) in patients who had not responded to or had relapsed after ≥ 24 weeks of treatment with conventional ...
Lim Young-Suk - - 2012
The combination of entecavir, a nucleoside analogue, and adefovir, a nucleotide analogue, would be a promising salvage treatment for chronic hepatitis B (CHB) patients who fail nucleoside/nucleotide analogue (NA) regimens. A total of 89 CHB patients who had failed NA regimens and were treated with entecavir plus adefovir combination for ...
Avila Marcos P - - 2012
To evaluate the long-term safety and visual acuity outcomes associated with epimacular strontium 90 brachytherapy combined with intravitreal bevacizumab for the treatment of subfoveal choroidal neovascularization because of age-related macular degeneration. Thirty-four treatment-naive patients with predominantly classic, minimally classic, and occult subfoveal choroidal neovascularization lesions participated in this prospective, 2-year, ...
Veritti Daniele - - 2012
To investigate the effect of the combination of photodynamic therapy with verteporfin and subconjunctival bevacizumab and triamcinolone acetonide on corneal neovascularization secondary to corneal graft failure. A patient with extensive deep and superficial corneal neovascularization underwent same day triple therapy with subconjunctival bevacizumab (1.25 mg), subconjunctival triamcinolone acetonide (40 mg), ...
Laws P M - - 2012
There are limited data on the use of ustekinumab outside of clinical trials. To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 dermatology centres in the U.K. and Ireland. A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab. Baseline Psoriasis Area ...
Saito Takefumi - - 2012
The use of budesonide/formoterol as both maintenance and reliever therapy in asthma is recommended in many countries; however, there are limited data available for the Asian patient population. This study aimed to evaluate the short-term safety and tolerability of a fixed high-dose combination of the inhaled corticosteroid budesonide and the ...
Sy Aileen - - 2012
To compare the clinical course and effect of adjunctive corticosteroid therapy in Pseudomonas aeruginosa with those of all other strains of bacterial keratitis. Subanalyses were performed on data collected in the Steroids for Corneal Ulcers Trial (SCUT), a large randomized controlled trial in which patients were treated with moxifloxacin and ...
Kim Won Ho - - 2012
Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 play a key role in the pathogenesis of in-stent restenosis. We investigated the effect of a short-term therapy of celecoxib, a COX-2 inhibitor, with or without doxycycline, an MMP inhibitor, after coronary stenting on inflammatory biomarkers and neointimal hyperplasia. A total of 75 patients ...
Kim Jin-Bae - - 2012
Hybrid therapy with catheter ablation of the cavo-tricuspid isthmus (CTI) and continuation of anti-arrhythmic drugs (AAD), or electrical cardioversion with AADs might be alternative treatments for patients with persistent atrial fibrillation (AF). The goal of study was to assess the long term success rate of hybrid therapy for persistent AF ...
Nahm Dong-Ho - - 2012
The clinical efficacy of subcutaneous allergen immunotherapy (SCIT) for the treatment of patients with severe atopic dermatitis (AD) using house dust mite (HDM) extract has been reported. Cyclosporin has been regarded as an effective medication for treatment of severe AD. In this study, we investigated a clinical usefulness of combined ...
Kim Seung Young - - 2012
We compared three times daily dual therapy with standard triple therapy for effectiveness and safety in H. pylori infection. Two hundred and four H. pylori positive patients with peptic ulcer were randomly assigned to one of two regimens: (i) triple therapy with amoxicillin, clarithromycin and lansoprazole twice daily for 2 weeks or ...
Nelson David R - - 2012
Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). This phase 2, double-blind international trial evaluated the optimal treatment regimen of balapiravir plus peginterferon alfa-2a (40KD)/ribavirin. Treatment-naive genotype 1 patients (N = 516) were randomized to one ...
Qureshi Adnan I AI Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA. - - 2012
The results of prematurely terminated stenting and aggressive medical management for preventing recurrent stroke in intracranial stenosis (SAMMPRIS) due to excessively high rate of stroke and death in patients randomized to intracranial stent placement is expected to affect the practice of endovascular therapy for intracranial atherosclerotic disease. The purpose of ...
Kircik Leon H LH Mount Sinai Medical Center, New York, NY, USA. - - 2012
Clinical studies as well as histologic data maintain that tretinoin improves the appearance of photodamage; however, the long-term benefits of tretinoin 0.02% in moderate to severe photodamage have not been established. We performed independent assessments to demonstrate the long-term safety and efficacy of tretinoin emollient cream 0.02% for moderate to ...
Attumi Taraq A TA Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, - - 2012
Helicobacter pylori infections have become increasingly difficult to treat as antimicrobial resistance has increased. The aim of this study was to test the hypothesis that a 6-week dual regimen of amoxicillin 1 gm and omeprazole 20 gm therapy b.i.d. would cure at least 90% of treatment-naïve H. pylori infections. This ...
Gupta Seema R SR From the Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, - - 2012
To report the results of intravitreal use of ranibizumab in a patient with macular edema due to Eales disease. This was an open-label, Phase 1, 6-month study of the safety and efficacy of intravitreally administered ranibizumab in patients with macular edema due to Eales disease. A single patient was eligible ...
Park Sang Woo - - 2011
BACKGROUND: Percutaneous ablation of incompetent perforators has been introduced as a safe and efficacious alternative. OBJECTIVE: To compare two methods of treating incompetent thigh perforator and great saphenous veins (GSV). MATERIALS AND METHODS: Patients with varicose veins of CEAP C2 and C3 with incompetent perforating veins (IPVs) in the thigh ...
Nuño-González A - - 2011
BACKGROUND AND OBJECTIVES: Treatment of mucosal vascular lesions is a challenge for dermatologists, although various approaches have proven efficacy, including surgery, sclerotherapy, intralesional injection of corticosteroids, transfixion, and laser therapy. The aim of this study was to describe the results of treatment with neodymium:yttrium-aluminum-garnet (Nd:YAG) laser in 11 patients with ...
McLeod Michelle M - - 2011
CONTEXT: Arthroscopic partial meniscectomy (APM) following meniscal tear has been widely accepted and associated with quick return to activity. Unfortunately, meniscectomy is associated with risk for knee osteoarthritis, which may be attributed to post-surgical quadriceps weakness. This has important implications as the quadriceps play a prominent role in knee stabilization ...
Kobayashi Shigeto - - 2012
We evaluated the efficacy, pharmacokinetics, and safety of adalimumab in Japanese patients with active ankylosing spondylitis (AS) who had an inadequate response to, or who were intolerant of, treatment with ≥1 nonsteroidal anti-inflammatory drugs (NSAIDs). This phase 3, multicenter, open-label trial assessed the percentage of patients with a 20% response ...
Berruezo Antonio - - 2012
Ventricular tachycardia (VT) ablation in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) has a low success rate. A more extensive epicardial (Epi) arrhythmogenic substrate could explain the low efficacy. We report the results of combined endocardial (Endo) and Epi VT ablation and conducting channel (CC) elimination. Eleven consecutive patients with ...
Fytagoridis Anders - - 2011
PurposeThe ventral intermediate nucleus of thalamus is the standard target for deep brain stimulation (DBS) in essential tremor (ET). However, favourable data have recently highlighted the caudal zona incerta (cZi) as an alternative target. Reports concerning the long-term results are however lacking, and we have therefore evaluated the long-term effects ...
Hughes Stella - - 2011
BackgroundThe Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires ...
Valentino Leonard A - - 2011
Background: Prophylaxis with factor VIII (FVIII) is considered the optimal treatment for managing hemophilia A patients without inhibitors. Objectives: To compare the efficacy of two prophylaxis regimens (primary outcome) and of on-demand and prophylaxis treatments (secondary outcome), and to continue the evaluation of immunogenicity and overall safety of ADVATE Antihemophilic ...
Gc Rajkumar - - 2011
OBJECTIVE: The purpose of this study was to eliminate orthodontic treatment in mild to moderate cases of condylar hyperplasia in its early stages by condylectomy. PATIENTS AND METHODS: A total of five patients (two females and three males) aged between 17 and 40 years were treated with unilateral condylectomy of ...
Matsuzaki Juntaro - - 2012
Sitafloxacin-based triple therapy achieved 83.6% (per-protocol) and 78.2% (intention-to-treat) success in eradicating Helicobacter pylori among 78 Japanese patients after clarithromycin-based first-line and metronidazole-based second-line triple therapies failed. Eradication succeeded in 32 out of 43 patients, even with gyrA mutation-positive Helicobacter pylori (per protocol). The position of the gyrA mutation (N87 ...
Janmohamed Sherief R - - 2012
Haemangioma of infancy (HOI) is the most frequently occurring benign tumour of infancy. Alarming HOI require treatment. Current therapy is empirically based; corticosteroids are often administered but in recent publications propranolol was reported to be more effective. Peri-ocular HOI are highly sensitive to corticosteroids. Our goal was to evaluate the ...
Cho Hyun Hee HH Department of Dermatology, Seoul National University Boramae Hospital, Seoul, - - 2013
Recently, tranexamic acid (TNA) containing oral medication has gained public attention, claiming for whitening effects. This study was performed to evaluate the clinical efficacy and safety of oral TNA as an adjuvant to intense pulsed light (IPL) and laser treatment in melasma. A total of 51 patients were included in ...
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