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Tutela John Paul JP Division of Plastic and Reconstructive Surgery, University of Louisville School of Medicine, Louisville, - - 2014
Oral incompetence is a problem frequently experienced after free-flap reconstruction of the oral cavity for patients with oral carcinoma. We describe an interesting treatment modality to deal with this pathology. A 60-year-old woman diagnosed with squamous cell carcinoma of her oral floor was treated with chemoradiation with complete response, and ...
Alizadeh M M . - - 2014
Peyronie's disease described as penile curvature, fibromathosis and pain that occur most often in men aged 40 to 60 years. The main complaint that caused the patient to visit the clinic is nodules on the upper surface of the penis, causing curvature and distortion particularly during erection, but they don't ...
Boettiger David Charles DC The Kirby Institute, UNSW Australia, Sydney, New South Wales, - - 2014
Antiretroviral therapy (ART) has evolved rapidly since its beginnings. This analysis describes trends in first-line ART use in Asia and their impact on treatment outcomes. Patients in the TREAT Asia HIV Observational Database receiving first-line ART for ≥6 months were included. Predictors of treatment failure and treatment modification were assessed. ...
Dimopoulos M A MA Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, - - 2014
Data from two randomized pivotal, phase 3 trials evaluating the combination of lenalidomide and dexamethasone in relapsed/refractory multiple myeloma (RRMM) were pooled to characterize the subset of patients who achieved long-term benefit of therapy (progression-free survival ⩾3 years). Patients with long-term benefit of therapy (n=45) had a median duration of ...
Piekarska Anna - - 2014
The aim of this study is to assess the efficacy of an initial dose of ribavirin administered before a 48-week course of treatment with peg-IFN + ribavirin in treatment-naïve patients and in patients after previous failure of CHC treatment. A total of 103 patients with chronic hepatitis C infected with ...
Karamichos Dimitrios D Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, DMEI PA-409, Oklahoma City, OK 73104, USA. - - 2014
Keratoconus (KC) is a bilateral, asymmetric, corneal disorder that is characterized by progressive thinning, steepening, and potential scarring. The prevalence of KC is stated to be 1 in 2000 persons worldwide; however, numbers vary depending on size of the study and regions. KC appears more often in South Asian, Eastern ...
Dong Lin L Department of Clinical Immunology and Rheumatology, The Affiliated Hospital of Guilin Medical College Guilin 541001, - - 2014
The objective of the study was to investigate whether subclinical hypothyroidism is a risk factor for a delayed clinical complete response in patients with SLE. This study included 363 patients with SLE classified according to the ACR classification criteria. These patients were divided into three groups: those who had subclinical ...
Huet Sarah S Laboratoire d'hématologie, Centre de Biologie Sud, Centre Hospitalier Lyon Sud, Pierre-Benite, France; Unité Mixte de Recherche 5239 Centre National de la Recherche Scientifique, Faculté de médecine Lyon Sud, Oullins, - - 2014
Recent studies demonstrate that early molecular response to tyrosine-kinase inhibitors is strongly predictive of outcome in chronic myeloid leukemia patients and that early response landmarks may identify patients at higher risk for transformation who would benefit from an early switch to second-line therapy. In this study, we evaluated the ability ...
Angadi Savita S SS P.G. Department of Shalakya Tantra, Shri J.G.C.H.Society's Ayurvedic Medical College, Ghataprabha, Belgaum, - - 2014
Vyanga is one of the Kshudraroga, characterized by the presence of Niruja (painless) and Shavavarna Mandalas (bluish-black patches) on face. It is one of the most common diseases as regards the face is concerned. On the basis of clinical features, it can be compared with facial melanosis, one of the ...
Yang Bo B Kidney institute of CPLA, Division of Nephrology, Changzheng hospital, Second Military Medical University, Shanghai, - - 2014
This study was aimed at determining the effects and safety of Da-Cheng-Qi decoction (DCQD) or DCQD combined with conservative therapy in patients with intestinal obstruction. PubMed, EMBASE, Cochrane Controlled Trials Register, and several other databases were searched. Randomised controlled trials (RCTs) of DCQD or DCQD plus conservative therapy in patients ...
Bhatnagar Rahul R http://orcid.org/0000-0003-3906-1997 Respiratory Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, UK Academic Respiratory Unit, University of Bristol, Bristol, - - 2014
The management of recurrent malignant pleural effusions (MPE) can be challenging. Various options are available, with the most efficacious and widely used being talc pleurodesis. Talc can either be applied via a chest drain in the form of slurry, or at medical thoracoscopy using poudrage. Current evidence regarding which method ...
Rezaieyazdi Zahra Z Rheumatic Diseases Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, - - 2014
Mycophenolate mofetil (MMF) has long been used to manage lupus nephritis. Despite research on its long-term efficacy, it is still warranted to conduct further investigation regarding its indications, safety and outcome. This study was intended to evaluate our proposed protocol in maintenance therapy with MMF. Twenty-four lupus nephritis patients were ...
Ismail Sohair S National Hepatology and Tropical Medicine Research Institute (Sohair Ismail, Kamal Hassan Kamal), Cairo University, - - 2014
Lamivudine monotherapy is effective in suppressing hepatitis B virus (HBV) replication to undetectable levels by PCR, in ameliorating liver disease and to some extent in achieving HBsAg seroconversion. This study aimed at assessing the virological and biochemical responses as well as breakthrough in HBeAg-negative chronic HBV (CHB) Egyptian patients receiving ...
Gaskell Katherine M KM Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, United - - 2014
We have previously reported high ten-week mortality from cryptococcal meningitis in Malawian adults following treatment-induction with 800mg oral fluconazole (57% [33/58]). National guidelines in Malawi and other African countries now advocate an increased induction dose of 1200mg. We assessed whether this has improved outcomes. This was a prospective observational study ...
Fernando Ruchira S W - - 2014
To assess the effectiveness of adopting endovenous laser treatment (EVLT) as the primary treatment modality for varicose veins at Auckland City Hospital (Auckland, New Zealand). The outcomes of 354 consecutive EVLT procedures performed between 2007 and 2013 were reviewed. Data was collected from a prospectively maintained procedural database and by ...
Salma Umme U Department of Gynecology, Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan 410013, - - 2014
The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations ...
Goljan-Geremek Anna A - - 2014
The first-line therapy in chronic sarcoidosis, according to WASOG/ATS/ERS recommendations, is GCS. This therapy is associated with significant adverse effects and finally does not alter the natural history of the disease. The objective of our study was to evaluate the efficacy and safety of monotherapy with MTX, as an alternative ...
Helbling Peter P Federal Office of Public Health, Bern, - - 2014
To assess outcomes 24 months after treatment start for multidrug-resistant tuberculosis (MDR-TB). Cohort study of all culture-positive MDR-TB cases notified in Switzerland from 01/2003 to 07/2010. Fifty-one cases were observed, with a median age of 26 years (range 2-56). Twenty-seven were male, five of Swiss origin, 46 of foreign origin ...
Sterr Annette A School of Psychology, University of Surrey , Guildford , - - 2014
CI therapy is effective in patients with relatively good levels of residual arm function but its applicability to patients with low-functioning hemiparesis is not entirely clear. In the present study, we examined the feasibility and efficacy of the CI therapy concept in patients with very limited upper arm function prior ...
Ten Cate-Hoek Arina J AJ Laboratory for Thrombosis and Hemostasis, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The - - 2014
Post-thrombotic syndrome (PTS) is a serious complication of deep vein thrombosis (DVT) of the leg that affects 20-50% of patients. Once a patient experiences PTS there is no treatment that effectively reduces the debilitating complaints. Two randomised controlled trials showed that elastic compression stocking (ECS) therapy after DVT for 24 months ...
Hashemi Mostafa M Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, - - 2014
This study was done to evaluate the effect of itraconazole on clinical symptoms and radiologic findings in patients with chronic rhinosinusitis and nasal polyposis after surgery. In a clinical trial which was conducted in Alzahra and Kashani hospitals, from November 2011 to December 2012, 22 patients with recurrent postsurgical chronic ...
Emami Mohammad Hassan MH Poursina Hakim Research Center Institute, Isfahan University of Medical Sciences, Isfahan, - - 2014
Increasing antibiotic resistance of Helicobacter pylori (H. pylori) which is associated with diseases of the upper gastrointestinal tract, has made alternative treatments necessary. This study compares the efficacy of adding N-acetyl cysteine (NAC) to standard regimen for H. pylori eradication. We conducted a randomized, open-label trial, comparing the efficacy of ...
Wiesmann Frank F HIV & Hepatitis Research, PZB Aachen, Aachen, - - 2014
Introduction: An association of persistent low level viremia (LLV) below 500 copies/mL and a higher risk of therapy failure is still point of controversial discussion. Furthermore, it seems that LLV occurs more frequently in patients with protease-inhibitor regimens than in NNRTI- / or integrase-inhibitor containing therapies. The focus of this ...
Vas Krisztina K Department of Dermatology and Allergology Clinic, University of Szeged, Korányi Fasor 6, Szeged 6720, - - 2014
The aim of this study was to investigate the efficacy of the sequential combined 585 nm PDL and the 1064 nm neodymium:yttrium-aluminium-garnet laser (PDL/Nd:YAG) in the treatment of surgical scars and to evaluate the short-term effects by in vivo confocal microscopy (RCM) and the long-term effects by clinical assessment of the scars. ...
Bedi Pallavi P Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, - - 2014
Background:We introduced domiciliary intravenous (IV) antibiotic therapy in patients with bronchiectasis to promote patient-centred domiciliary treatment instead of hospital inpatient treatment.Aim:To assess the efficacy and safety of domiciliary IV antibiotic therapy in patients with non-cystic fibrosis bronchiectasis.Methods:In this prospective study conducted over 5 years, we assessed patients' eligibility for receiving ...
Manabe Yasuaki Y Department of Dermatology, Tokai University School of Medecine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. - - 2014
A 7-year-old boy, taking lessons at a yacht school at Enoshima in Kanagawa prefecture in Japan, recognized a linear eruption on his left lower leg during practice in August 2012. As it gradually enlarged, he visited a local medical clinic. The eruption initially improved with topical treatment but exacerbated in ...
Samarei R R . - - 2014
Chronic media otitis is a common cause of reference to ear, nose and throat clinics and the treatment is one of the health problems among ENT specialists. Ciprofloxacin drop that is of fluoroquinolone drug class due to good treatment effect is now widely used in the treatment of chronic media ...
Rana Zaker Z Department of Radiation Medicine, Georgetown University Hospital , Washington, DC , - - 2014
Irritative voiding symptoms are common in elderly men and following prostate radiotherapy. There is limited clinical data on the impact of hypofractionated treatment on irritative voiding symptoms. This study sought to evaluate urgency, frequency, and nocturia following stereotactic body radiation therapy (SBRT) for prostate cancer. Patients treated with SBRT monotherapy ...
Bjørn M E ME Department of Hematology, Roskilde University Hospital, Køgevej 7-13, 4000 Roskilde, - - 2014
We report a 55 year old woman with post-ET PV for 12 years, who experienced resolution of severe constitutional symptoms within 3 days, a marked reduction in splenomegaly and a rapid decline in the JAK2V617F allele burden during combination therapy with interferon-alpha2a and ruxolitinib. Within 4 weeks the patient achieved ...
Perera Gayan G King's College London (Institute of Psychiatry), London, United - - 2014
Acetylcholinesterase inhibitors (AChEIs) are widely used to delay cognitive decline in Alzheimer's disease. Observational studies in routine clinical practice have shown cognitive improvement in some groups of patients receiving these agents but longitudinal trajectories before and after AChEI initiation have not previously been considered. To compare trajectories of cognitive function ...
Lin Lung-Huang LH Departments of Pediatrics, Cathay General Hospital, Taipei, Taiwan School of Medicine, FuJen Catholic University, New Taipei City, - - 2014
To assess the effectiveness of conservative treatment for adhesive small bowel obstruction (ASBO) in children. Systematic review of studies involved children with ASBO who received initial conservative/non-operative treatment. The search was performed in April 2013 using PubMed (see online supplementary file 1), current contents, and the Cochrane database. Children with ...
Osmonov Daniar Kurmanbekovich DK Department of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, - - 2014
This paper reports treatment of a 76-hour low-flow priapism with a shunting procedure that was first described by Barry in 1976. We were able to observe the preservation of erectile function despite the long period of ischemia. A review of the literature shows that there are few reports of erectile ...
Luo Ru-Bin RB Department of Emergency Medicine, Research Institute of Emergency Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China - - 2014
Abstract Osteonecrosis or avascular osteonecrosis (AVN) of the femoral head is a devastating multifactorial disease that affects 20 000 persons each year in the United States. The purpose of this systematic review was to determine the efficacy and safety of alendronate for adult AVN during short- and long-term follow-up. Electronic ...
Shamir Reuben R - - 2014
Deep brain stimulation (DBS) is an established therapy for the management of advanced Parkinson's disease (PD). However, the coupled adjustment of pharmacologic therapy and stimulation parameter settings is a time-consuming process and treatment outcomes are not always optimal. In this study, we develop a linear function that relates the DBS ...
Antinori Andrea A Infectious Diseases, National Institute of Infectious Diseases, Rome, - - 2014
In previous studies, protease inhibitor (PI) monotherapy has shown trends for higher low-level elevations in HIV-1 RNA compared to triple therapy, but no increase in the risk of drug resistance. A total of 273 patients with HIV-1 RNA <50 copies/mL for over 24 weeks on current antiretrovirals switched to DRV/r ...
Chang Rita Yuk-Kwan RY Department of Surgery, The University of Hong Kong, Hong - - 2014
Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves' disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12-18 ...
Denoël Paule P 0000-0003-0735-4664 Emergency Service, Europe Hospital, 1040 Brussels, - - 2014
Several studies have reported underprescription of anticoagulants in atrial fibrillation (AF). We conducted an observational study on 142 out of a total of 995 consecutive ≥75 years old patients presenting AF (14%) when admitted in an emergency unit of a general hospital, in search of geriatric characteristics that might be ...
Fujita Tetsuo T Department of Respirology, Graduate School of Medicine, Chiba University, - - 2014
Pulmonary arterial hypertension (PAH) is a rare complication, but a significant prognostic factor in patients with Sjögren's syndrome (SjS). Despite its efficacy, the long-term use of intravenous epoprostenol is sometimes complicated by adverse effects, such as catheter-related infection. This case involves a 38-year-old woman with PAH associated with SjS (PAH-SjS) ...
Fosså Sophie D SD National Resource Center for Late Effects after Cancer Treatment, Norwegian Radium Hospital, Oslo University Hospital, Radiumhospital, Oslo, - - 2014
In patients with metastatic castration-resistant prostate cancer (mCRPC), the finding of less than five circulating tumor cells (CTCs)/7.5 mL blood before start of cytotoxic treatment or shortly thereafter indicates prolonged survival. In this descriptive pilot study, we investigated whether this association depends on the sequence of the therapeutic attempts. CTCs ...
Mirbehbahani Nb N Golestan University of Medical Sciences, Taleghani hospital, Janbazan Boulevard, Gorgan, - - 2014
Hemangiomas, usually, present at the first few months of life and are the most common benign tumor in children. There are various therapeutic methods for hemangioma. Capillary hemangioma is a type of hemangiomas. The steps of treatment of a child with capillary hemangioma in Taleghani Hospital of Gorgan, Iran, are ...
Weitz Jeffrey I JI Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University and the Thrombosis and Atherosclerosis Research Institute 237 Barton Street East, Hamilton, ON, L8L 2X2 - - 2014
New, non-vitamin K antagonist oral anticoagulants (NOACs) have been developed to overcome the limitations of warfarin. These include dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, and edoxaban, which inhibit factor Xa. In the US, rivaroxaban and apixaban are licensed for thromboprophylaxis after elective hip or knee arthroplasty, and rivaroxaban and ...
Dincă Octavian O Department of Oral and Maxillofacial Surgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; - - 2014
The authors report their experience using platelet-rich fibrin (PRF) therapy for the treatment of ten patients presenting bisphosphonate-related osteonecrosis of the jaw (BRONJ). The aim of our study was to evaluate the effect of this therapy on recurrent BRONJ and to describe the clinical and histopathological÷immunohistochemical staining features of PRF ...
Badawy Shawky Z A SZ Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, SUNY, Upstate Medical University, Syracuse, NY, - - 2014
A 42-year-old multiparous patient presented for consultation as a referral for management of recurrent catamenial pneumothorax. Evaluation by a pulmonologist failed to reveal any chest masses. She was treated for endometriosis using Danazol 800 mg daily for 6 months. Pneumothorax did not recur during treatment and during follow-up visits.
Jeger Raban R Cardiology, University Hospital Basel, - - 2014
During the last years, the numbers of interventions in structural heart disease such as transcatheter aortic valve implantation (TAVI), percutaneous treatment of mitral regurgitation using the MitraClip, closure of atrial septal defects (ASD) and others have constantly increased. While the 20th century was called the century of surgery, it appears ...
Iizuka Masahiro M Department of Gastroenterology, Akita Red Cross Hospital, - - 2014
A 29-year-old woman with ulcerative colitis underwent total colectomy with ileal-pouch-anal canal anastomosis in 1999. After the surgery, she developed refractory pouchitis. We administered metronidazole, mesalamine and ciprofloxacin; however, her clinical symptoms improved only very slightly. We initiated treatment with infliximab in June 2011 and discontinued the antibiotics. Thereafter, the ...
Mavija Milka - - 2014
Age-related macular degeneration (AMD) is a leading cause of irreversible serious vision damage in persons over 50 years of age. In treating AMD many medicaments are applied such as inhibitors of vascular endothelial growth factor (VEGF), have been very carefully included over the last few years after a series of ...
Takeda Sakurako S Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan ; Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women's Medical University, Tokyo, - - 2014
We aimed to evaluate the effect on the intraocular pressure (IOP) of a dorzolamide/timolol (1%/0.5%) fixed combination (DTFC) ophthalmic agent for 3 years. A total of 19 consecutive patients who had previously been treated with mono-therapy or any combination of a beta-blocker, carbonic anhydrase inhibitor, or prostaglandin analog, for primary ...
Naeini Farahnaz Fatemi FF Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, - - 2014
No ideal treatment has been established for Striae distensae (SD), particularly in the late phase (Striae Alba (SA)). Various types of lasers have been recently proposed as treatment options for SD. This study aims to compare the clinical efficacy of a fractional CO2 laser as well as a combination of ...
Ansari Julia G - - 2014
Atrial fibrillation affects approximately 5 million patients in the United States. The rate of stroke in adults with atrial fibrillation depending on their risk factors varies between 1-20% annually. Anticoagulation with vitamin K antagonists such as warfarin has been the mainstay therapy but it is cumbersome and requires close follow-up. ...
Nomura Hideyuki H Center for Liver Disease, Shin-kokura Hospital, - - 2014
Objective The sustained virological response (SVR) rate has improved to >70% for patients with hepatitis C virus genotype 1 treated with the triple therapy of telaprevir (TVR), pegylated interferon (PEG-IFN)-α, and ribavirin (RBV). However, this therapy has various adverse effects, although there have been no reports of it decreasing body ...
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