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Kuenzig M Ellen ME Department of Medicine, University of Calgary, Calgary, AB, - - 2014
Corticosteroids are effective for induction, but not maintenance of remission in Crohn's disease. Significant concerns exist regarding the risk for adverse events, particularly when corticosteroids are used for long treatment courses. Budesonide is a glucocorticoid with limited systemic bioavailability due to extensive first-pass hepatic metabolism and is effective for induction ...
Aubin François F Université de Franche Comté, EA3181, SFR4234 and Service de Dermatologie, Centre Hospitalier Universitaire, Besançon, - - 2014
Retrospective data have suggested the effectiveness of intravenous immunoglobulins (IVIG) for solar urticaria (SU). We sought to prospectively assess the efficacy of IVIG for SU. We conducted a multicentric phase II study to test the efficacy of a single course of IVIG (2 g/kg) in patients with severe and refractory ...
Vogl Matthias M Institute of Health Economics and Health Care Management (IGM), Helmholtz Zentrum München, German Research Center for Environmental Health, P.O. Box 1129, 85758, Neuherberg, Munich, Germany, - - 2014
We compare pre- and post-operative health-related quality of life (HRQoL) and length of stay after total hip replacement (THR) in matched German and English patient cohorts to test for differences in admission thresholds, clinical effectiveness and resource utilisation between the healthcare systems. German data (n = 271) were collected in a large ...
Pezzella A Thomas AT Cardiac Surgery Research, Inova Heart and Vascular Institute, Inova Fairfax Hospital, Falls Church, - - 2014
Glycemic control in the perioperative period decreases mortality and morbidity, but data are scarce with regard to the effects of glucose control approaches on survival. We assessed long-term survival in patients treated with 2 strategies of glucose control after first-time isolated coronary artery bypass graft. In a previously published trial, ...
Vashi Pankaj G - - 2014
In cancer patients where gastrointestinal function is marginal and malnutrition significant enough to result in the requirement for intensive nutrition support, parenteral nutrition (PN) is indicated. This longitudinal study examined the quality of life (QoL) and nutritional outcomes in advanced cancer patients receiving home PN (HPN). Fifty-two adult cancer patients ...
Bogaard Kjell K Department of Cardiology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands, - - 2014
High-pitch prospective ECG-triggered helical (PTH) protocols for coronary computed tomography angiography (CCTA) have demonstrated adequate image quality (IQ) in small-scaled studies and highly selected patients. Clinical applicability in a general clinical population is uncertain. This study evaluated the implementation of a PTH protocol in a routine clinical cohort, focusing on ...
Alradwan Hussain H Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; Saudi Ministry of Higher Education, Riyadh, Saudi - - 2014
Lower extremity and pelvis kinematics have been shown to be abnormal in patients with femoroacetabular impingement (FAI). We conducted this systematic review to evaluate the current status of gait and lower extremity kinematics as an outcome measure in patients treated surgically for FAI. We searched the Embase, Medline, and PubMed ...
Sabadotto Mélanie M Skin Research Center Pierre Fabre Dermo-cosmétique, 2 rue viguerie BP 3071, 31025 Toulouse Cedex 03, - - 2014
Wound healing studies require standardised methods for evaluating wounding and skin repair. Our study aimed to demonstrate the suitability of the erbium-YAG (Er-YAG) laser method to produce reliable epidermal lesions for evaluation of different skin repair creams. Skin de-epidermised by Er-YAG laser (four uniform epidermal ablations, area 8 × 8mm, in 21 ...
Yasar Bulent B Department of Gastroenterohepatology, Camlica Erdem Hospital, Alemdag Yanyol Street, 34696, Üsküdar, Istanbul, Turkey, - - 2014
Polypectomy with jumbo forceps (JF) and polypectomy with hot biopsy forceps (HBF) are still widely used techniques for removal of diminutive colorectal polyps (DCPs). JF may be more effective for the removal of DCPs because of their larger size. To evaluate the histological quality and adequacy of DCPs resected using ...
Filipozzi Pierre P Department of Nephrology, Dialysis, and Transplantation, CHU Nancy, F-54 511, Vandoeuvre-les-Nancy, France; CHU Nancy, Pôle S2R, Epidémiologie et Evaluation Cliniques, Nancy, F-54 000, France; INSERM, CIC-EC, CIC 1433, Nancy, F-54 000, - - 2014
The goal of this study is to compare patient-reported quality of life (PRQOL) evolution between two groups of end-stage renal disease patients with secondary hyperparathyroidism (SHPT). The first with a cinacalcet prescription within 3 months after a diagnosis of SHPT (early group) and a second group of patients with a later ...
Geavlete Bogdan B Saint John Emergency Clinical Hospital, Department of Urology, Bucharest, Romania ; - - 2014
Objectives: The study compared the transurethral resection in saline (TURis), transurethral vaporization in saline (TUVis), bipolar plasma enucleation of the prostate (BPEP) and open prostatectomy (OP) in a single center, prospective, randomized controlled clinical setting exclusively involving large prostate patients. Patients and Methods: During a 4½ year' enrollment period, 320 ...
Granel Brigitte B Internal Medicine Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, Marseilles, France Vascular Research Center Marseille, INSERM UMRS-1076, Aix-Marseilles University, Marseilles, - - 2014
In patients with systemic sclerosis (scleroderma, SSc), impaired hand function greatly contributes to disability and reduced quality of life, and is insufficiently relieved by currently available therapies. Adipose tissue-derived stromal vascular fraction (SVF) is increasingly recognised as an easily accessible source of regenerative cells with therapeutic potential in ischaemic or ...
Hutt Jonathan R B JR Epsom General Hospital, Dorking Road, Epsom, Surrey, KT18 7EG, UK, - - 2014
The place of knee arthroscopy as a therapeutic option for osteoarthritis (OA) has been the subject of some debate. The hypothesis for this study was that arthroscopic debridement is beneficial in patients with OA who have significant mechanical symptoms. Forty-three patients with radiological OA on plain radiographs and mechanical symptoms ...
Large Michael C MC Department of Surgery, Section of Urology, The University of Chicago Medical Center, Chicago, IL; Urology of Indiana, Greenwood, - - 2014
To better define health-related quality of life (HRQOL) for patients undergoing radical cystectomy (RC) and urinary diversion. Patients undergoing RC and urinary diversion for urothelial carcinoma by 1 of 2 surgeons (G.D.S. or N.D.S.) had a HRQOL assessment at baseline and at follow-up using the validated, bladder cancer-specific Functional Assessment ...
Randall J J University Hospitals - - 2014
The study assessed the efficacy of laparoscopic ventral mesh rectopexy (LVMR) for full thickness external rectal prolapse (ERP), including recurrent prolapse. A prospective database identified all patients undergoing LVMR for ERP over the 16yr period to December 2013. Clinical outcome, Cleveland Clinic Incontinence Score (CCIS), quality of life (QOL) and ...
Verim L L Department of Urology, Haydarpasa Numune Research and Training Hospital, Istanbul, - - 2014
Aortoiliac occlusive disease (AIOD) can occur anywhere from the distal abdominal aorta to the common femoral arteries. Patients with AIOD may be asymptomatic or may have intermittent claudication or critical limb ischemia. ED in the young males may be the first symptom of aortoiliac disease. The aims of this study ...
Maldonado Pedro A PA Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, - - 2014
Patient-reported outcomes and satisfaction are recognized as being equally important as traditional objective measures of success following midurethral sling (MUS) procedures. The objective of this article is to review the success after MUSs in the context of patient satisfaction. Patient satisfaction for both transobturator and retropubic MUSs at 2 years ...
Lindqvist M M Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden; Institution for Physiology & Pharmacology, Karolinska Institute, Stockholm, - - 2014
The impact of anaesthetic agents on cognitive recovery during the first post-operative week in a middle-aged population undergoing general anaesthesia is insufficiently studied. We hypothesised that patients receiving anaesthesia based on desflurane would have a quicker recovery and regain cognitive capacity faster than patients receiving anaesthesia based on propofol. We ...
Cvetanovich Gregory L GL Division of Sports Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.. Electronic address: - - 2014
To compare outcomes of anterior cruciate ligament (ACL) reconstruction with hamstring autograft versus soft-tissue allograft by systematic review and meta-analysis. A systematic review of randomized controlled studies comparing hamstring autograft with soft-tissue allograft in ACL reconstruction was performed. Studies were identified by strict inclusion and exclusion criteria. Descriptive statistics were ...
Better Hadar - - 2014
Objective: Patients' perceptions of recovery following sinus augmentation procedures have scarcely been documented. The aim of the present prospective pilot clinical study was to evaluate the patient's perception of immediate postoperative recovery after sinus augmentation, using a minimally invasive implant device. Method and Materials: Eighteen patients (8 men, 10 women), ...
Nijenhuis Vincent J VJ From the Department of Cardiology (V.J.N., M.J.S., M.C.P., J.M.t.B.) and Department of Cardiothoracic Surgery (R.H.H., T.L.d.K.), St. Antonius Hospital, Nieuwegein, The - - 2014
Significant prosthetic paravalvular leakage (PVL) could have serious clinical consequences and impairs survival. Reoperation is associated with a high mortality rate, and transcatheter closure is a new treatment modality for high-risk patients. The goal of this study was to determine safety and midterm clinical efficacy of transcatheter PVL closure using ...
Gordon Adam A Department of Urology, University of California, Irvine, Orange, - - 2014
To address a major concern driving treatment intervention, we studied incontinence and urinary quality of life (QOL) before and after robotic-assisted radical prostatectomy (RARP). In men with severe lower urinary tract symptoms (LUTS), this is the first observational study analyzing short- and long-term urinary outcomes of RARP. RARP was performed ...
Fizazi Karim K Institut Gustave Roussy, University of Paris Sud, Villejuif, France. Electronic address: - - 2014
In the AFFIRM trial of patients with metastatic castration-resistant prostate cancer after progression with docetaxel treatment, enzalutamide significantly increased overall survival compared with placebo. Here we present the prospectively defined analyses of some secondary endpoints, including occurrence of skeletal-related events, measures of pain control, and patient-reported health-related quality of life ...
Matthews D D Department of Trauma and Orthopedic Surgery London Hospital University College, London, UK - - - 2014
Amputation in athletes has a substantial impact on lifestyle and sporting activity, as well as self-perception and quality of life. The impact of limb loss on athletic ability will vary depending on the cause of amputation and the anatomical location of the amputation. The use of sporting activity for rehabilitation ...
Rampersaud Y Raja YR The Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, and the Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital University Health Network, University of Toronto, Toronto, - - 2014
Decompression alone (D) is a well-accepted treatment for patients with lumbar spinal stenosis (LSS) causing neurogenic claudication; however, D is controversial in patients with LSS who have degenerative spondylolisthesis (DLS). Our goal was to compare the outcome of anatomy-preserving D with decompression and fusion (DF) for patients with grade I ...
Gordon Morris M School of Medicine and Dentistry, University of Central Lancashire, Preston, - - 2014
Crohn's disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions. Purine analogues have been used to maintain surgically-induced remission in CD, but the effectiveness of these agents is unclear. The objectives were to evaluate the efficacy and safety ...
van der Heijden L L Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the - - 2014
We retrospectively reviewed 30 patients with a diffuse-type giant-cell tumour (Dt-GCT) (previously known as pigmented villonodular synovitis) around the knee in order to assess the influence of the type of surgery on the functional outcome and quality of life (QOL). Between 1980 and 2001, 15 of these tumours had been ...
Ouyang Yun Y Department of Urology, Navy General Hospital of the Chinese People's Liberation Army , Haidian District, Beijing, China - - 2014
Abstract Objective: Our aim was to evaluate the impact of 160 W Greenlight laser vaporization of the prostate on erectile function by the International Index of Erectile Function (IIEF-5) in 1-year follow-up in patients with lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). Background data: Although high-power ...
Nakajima Ayako A Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan, - - 2014
To clarify the impact of comorbidities on treatment strategies and outcomes in patients with rheumatoid arthritis (RA) using a large observational RA cohort, the presence of comorbidities was assessed using the Charlson Comorbidity Index (CCI). Changes in medication, disease activity by Disease Activity Score-28 joint count (DAS28) over 6 months, disability ...
Nast A A Division of Evidence-Based Medicine (dEBM), Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
Background Management of anticoagulation and anti-platelet drugs during cutaneous surgery is still a challenge for many dermatologists and standards of care with respect to stopping, continuing or bridging vary widely. Methods We performed a systematic review (Medline, Cochrane Library, until August 27th, 2013) of studies assessing the risk of complications ...
He Mao Lin ML Division of Spinal Surgery, 1st Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, China, - - 2014
Total knee arthroplasty (TKA) is a common form of orthopaedic surgery. Venous thromboembolism (VTE), which consists of deep venous thrombosis (DVT) and pulmonary embolism (PE), is a major and potentially fatal complication after TKA. The incidence of DVT after TKA is 40% to 80% and the incidence of PE is ...
Sophie Galanth G Physical Medicine and Rehabilitation Department, University Hospital, 97159 Pointe à Pitre, Guadeloupe, - - 2014
To evaluate functional outcome and quality of life one year post stroke in a Caribbean population. Caribbean stroke patients are younger than those in North American/European countries. Therefore, their functional outcome cannot be predicted on the basis of studies on other populations. Prospective study of patients with a first hemispheric ...
Lee Seung Soo SS *Department of Surgery, Kyungpook National University Hospital †Gastric Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of - - 2014
The study assessed long-term shifting patterns in quality of life (QoL) after distal subtotal gastrectomy relative to an estimated healthy QoL, and compared them to shifting patterns interpreted in terms of a preoperative QoL baseline. QoL data from 127 gastric cancer patients who underwent open distal subtotal gastrectomy were obtained ...
Gronda Edoardo E Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni (Milan), - - 2014
Heart failure (HF) pathophysiology is believed to be mediated by autonomic dysfunction, including chronic sympathoexcitation and diminished baroreflex sensitivity, which correlate with mortality risk. Baroreflex activation therapy (BAT) is a device-based treatment providing chronic baroreflex activation through electrical stimulation of the carotid sinus. BAT chronically reduces sympathetic activity in resistant ...
Hauser C C Department of General Surgery and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, - - 2014
To evaluate the cancer patients' quality of life (QoL) following esophagectomy the focus was placed on the impact of neoadjuvant treatment before surgery. For patients undergoing oncologic surgery, the QoL is generally accepted as an important outcome parameter in addition to clinical parameters. This prospective nonrandomized study evaluated QoL in ...
Diakomi Maria M From the *Department of Anesthesiology, Asklepieion Hospital of Voula; and †Department of Microbiology, University of Athens School of Medicine, Aretaieio Hospital, Athens, - - 2014
Appropriate pain management may positively affect outcome following hip fractures. Positioning patients for spinal anesthesia (SA) can be extremely painful. Peripheral nerve blockades are gaining popularity in this setting. This prospective, randomized study compares the efficacy of fascia iliaca compartment block (FICB) to intravenous (IV) fentanyl for positioning hip fracture ...
Delgado-Corcoran Claudia C 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Primary Children's Hospital, University of Utah, Salt Lake City, UT. 2Department of Systems Improvement, Primary Children's Hospital, Salt Lake City, - - 2014
To safely optimize blood testing and costs for pediatric cardiac surgical patients without adversely impacting patient outcomes. This is a quality improvement cohort project with pre- and postintervention groups. University-affiliated pediatric cardiac ICU in a tertiary care children's hospital. All patients were surgical patients for whom Risk Adjustment for Congenital ...
Helito Camilo Partezani CP Institute of Orthopedics and Traumatology, University of São Paulo, São Paulo, Brazil - - 2014
Patients who undergo transfemoral amputation after infection of a total knee arthroplasty do not have good functional outcomes and have major difficulty walking. To evaluate the quality of life and walking ability among patients who underwent amputation and among those who refused to undergo amputation following infection of a total ...
Ruckenstuhl Paul - - 2014
This study aimed to present functional results and patient's health related quality of life (HRQOL) data ten years after volar locked plate fixation (VPF) of unstable intra-articular distal radial fractures (DRF). Thirty-nine patients with a mean age of sixty-one years were operatively treated with VPF after intra-articular distal radial fractures. ...
Phan Kevin K The Collaborative Research (CORE) Group, Macquarie University, Sydney, New South Wales, - - 2014
Minimally invasive aortic valve replacement (AVR) is increasingly used as an alternative to conventional AVR, despite limited randomized evidence available. To assess the evidence base, a systematic search identified 50 comparative studies with a total of 12,786 patients. A meta-analysis demonstrated that minimally invasive AVR is associated with reduced transfusion ...
Gonzalez Saenz de Tejada Marta - - 2014
Patient expectations regarding surgery may be related to outcomes in total joint replacement (TJR). The aim of this study was to determine the association of patient expectations with health related quality of life (HRQoL) outcomes measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short Form 12 (SF-12) ...
Rogers S N SN Evidence-Based Practice Research Centre (EPRC), Faculty of Health and Social Care, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK, - - 2014
Consequences of treating head and neck cancer are reflected in health-related quality of life (HRQOL) patient-reported outcomes. HRQOL is an important outcome alongside survival and recurrence. However, relatively little HRQOL information is in a format that patients and oncology teams can easily interpret as a guide to likely outcomes following ...
Rosato Lodovico L Department of Surgery - Endocrine Surgical Unit, Ivrea Hospital, School of Medicine, ASL TO4, University of Turin, Turin, - - 2014
There is clinical evidence that post-total thyroidectomy (TT) patients can present persistent asthenia. The aim of this study was to evaluate the prevalence of asthenia symptoms in such patients, assess whether a chronic asthenia syndrome could be caused by TT or become evident after it. An observational study was carried ...
Duchalais Emilie E Institute of Digestive Disease, University Hospital of Nantes, 44093, Nantes, France, - - 2014
The percutaneous endoscopic ceacostomy (PEC) for antegrade colonic enemas (ACE) has recently been proposed as a less invasive alternative to the Malone procedure in chronic constipated patients. Although the feasibility and safety of this innovative approach has been demonstrated, its functional results remain unknown. The aim of this study was ...
Uhm Jieun J Allogeneic Blood And Marrow Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of - - 2014
Sclerotic chronic graft-versus-host disease (sclGVHD) is associated with significant morbidity and a poor quality of life. We reviewed a total of 502 patients diagnosed with chronic graft-versus-host disease (cGVHD) and analyzed the incidence and risk factors of sclGVHD, and long-term outcomes and immunosuppressive therapy (IST) cessation in patients with sclGVHD. ...
Lynch Susanna K SK Division of Vascular Surgery, Eastern Virginia Medical School, Norfolk, - - 2014
Our institutional quality-improvement (QI) initiative instituted a well-defined office follow-up schedule after arteriovenous fistula (AVF) creation, including an office visit within 30 days, fistulogram within 40 days, if indicated, and a second office visit within 55 days. In addition, a patient liaison contacted patients and dialysis units to improve follow-up. The purpose of ...
Zurstrassen Charles Edouard CE Interventional Radiology Department, A.C. Camargo Cancer Center , Sao Paulo, SP , - - 2014
Abstract Introduction: Placement of self-expanding metallic stents has been a standard palliative treatment for patients with inoperable biliary malignancy, aiming at improving quality of life via a minimally invasive procedure. This study aimed to evaluate the efficacy of percutaneous placement of expanded polytetrafluoroethylene/fluorinated ethylene propylene-covered metallic stents for palliation of ...
Wynn Gareth J GJ The Institute of Cardiovascular Medicine and Science, Research Unit, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, UK Imperial College London, London, SW7 2AZ, - - 2014
The recently published SARA study was a prospective, multi-centre randomized controlled trial that compared CA to antiarrhythmic drug therapy (ADT) in 146 patients with persistent atrial fibrillation (AF). The study found that recurrence of AF or atrial flutter occurred significantly less often in the CA arm compared to the ADT ...
Lee Sun-Young SY Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of - - 2014
Background and study aims: Pronase, a proteolytic enzyme, is known to improve mucosal visibility during esophagogastroduodenoscopy (EGD), but little is known about its effects on gastric biopsy. This study assessed whether endoscopic flushing with pronase improves the quality of gastric biopsy. Patients and methods: Consecutive patients who underwent EGD were ...
Chung Jae Seung JS Department of Urology, Haeundae Paik Hospital, Inje University, Busan, - - 2014
To compare the efficacy and safety of vaporesection without a morcellator, and vapoenucleation with a morcellator in thulium laser prostatectomy for the treatment of benign prostatic obstruction. Between March 2010 and January 2013, 405 patients underwent thulium:yttrium-aluminium-garnet laser prostatectomy. Among these patients, 150 patients who underwent thulium:yttrium-aluminium-garnet laser prostatectomy without ...
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