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Ogura Koichi K Department of Orthopaedic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, - - 2014
Although the elderly population is increasing rapidly, little information is available regarding how the risk of postoperative mortality and morbidity increases when combined with age and comorbidity burden in patients undergoing musculoskeletal tumor surgery. We evaluated the effect of age and comorbidity burden on the (1) postoperative complication rate and ...
Coskuner Enis Rauf ER Department of Urology, School of Medicine, YeniYuzyil University, Bagdat Cad. no. 448 Kat: 1, 81070, Suadiye-Istanbul, - - 2014
Bipolar plasma kinetic (BP) transurethral resection of prostate (TURP) has been proved to be a safe and effective treatment for benign prostatic enlargement (BPE). However, the role of bipolar TURP on large prostates over 100 g compared with open suprapubic prostatectomy (SP) in elderly patients (>65 years) has not ever been studied ...
Nozawa Akinori A Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan, - - 2014
We evaluated the preoperative and postoperative characteristics and prognosis of super-elderly patients with hepatocellular carcinoma (HCC). Four hundred and thirty-one patients who underwent hepatic resection for HCC were classified into three groups according to their age at the time of surgery: super-elderly (≥80 years; n = 20), elderly (70-80 years; n = 172) and younger (<70 years; ...
Robinson Thomas N TN Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Surgery, Denver Veteran's Affairs Medical Center, Denver, - - 2014
To determine whether the postoperative administration of tryptophan would be beneficial for elderly adults undergoing surgery who are at risk of developing postoperative delirium. Randomized, double-blind, placebo-controlled trial. Denver Veterans Affairs Medical Center. Individuals aged 60 and older undergoing major elective operations requiring a postoperative intensive care unit (ICU) admission ...
Raccah Denis D Department of Diabetology, University Hospital Sainte Marguerite, Marseille, - - 2014
The objective of this paper is to evaluate the pharmacokinetics (PK), efficacy and safety of lixisenatide (subcutaneous injection) in elderly (≥65 years) and very elderly (≥75 years) patients with type 2 diabetes mellitus (T2DM). We conducted a Phase I, single-centre, open-label study to evaluate the safety and pharmacokinetics of a single lixisenatide ...
Liao Jen-Chung JC Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kweishian, Taoyuan, 333, Taiwan, - - 2014
The vacuum phenomenon within an intervertebral disc is not an uncommon radiographic finding in the elderly. However, no reports in the English literature have focused on the effect of an anterior vacuum disc in relation to surgical outcome of same-segment spondylolisthesis. We hypothesized that instrumented posterolateral fusion is not adequate ...
Olsha Oded O Department of Surgery and Vascular Access Center, Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Hebrew University), Jerusalem, - - 2014
There is a worldwide surge in numbers of elderly people requiring hemodialysis accompanying the prevailing increase in longevity. There is a trend for central venous catheters to be preferentially placed in elderly patients, whereas others recommend routine use of grafts for surgical access. In our center, age has not been ...
Yamamoto Shuhei S Graduate School of Medical Sciences, Kitasato - - 2014
The purpose of this study was to clarify the effect of standing balance training on walking speed (short-term outcome) and cardiac events (long-term outcome) in elderly ischemic heart disease (IHD) patients. This was a retrospective cohort study. Ninety-two elderly (≥ 65 years) IHD patients who underwent an inpatient cardiac rehabilitation ...
Lee Soo Eon SE Department of Neurosurgery, Seoul National University - - 2014
Object Spinal stenosis with degenerative lumbar scoliosis (DLS) mostly occurs in the elderly population (typically > 65 years old), causing pain in the legs and back, claudication, and spinal deformity. The surgical strategy for DLS is controversial concerning the surgical approach, fusion area, decompression area, correction methods, and ideal angle ...
Rossi Ariane A From the *Department of Anesthesia, Lausanne University Hospital, Lausanne, Switzerland; †Department of Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland; ‡Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Centre for Addiction and Mental Health, Toronto, Canada; and §Memory Clinic, University Center for Medicine of Aging, Felix Platter Hospital, Basel, - - 2014
Cerebral cholinergic transmission plays a key role in cognitive function, and anticholinergic drugs administered during the perioperative phase are a hypothetical cause of postoperative cognitive dysfunction (POCD). We hypothesized that a perioperative increase in serum anticholinergic activity (SAA) is associated with POCD in elderly patients. Seventy-nine patients aged >65 years ...
Kanto Kari K Department of Orthopedics, Hatanpää Hospital, Hatanpäänkatu 24, P.O.Box 487, 33101, Tampere, - - 2014
The choice between unipolar and bipolar hemiarthroplasty for treatment of displaced intracapsular femoral neck fractures in elderly patients still remains controversial. Our objective was to compare series of elderly individuals with a displaced femoral neck fracture treated with either a cemented, modular unipolar or bipolar prosthesis with the same femoral ...
Grimaldi David D 1Medical Intensive Care Unit, Cochin University Hospital, Hopitaux Universitaires Paris Centre, AP-HP, Paris, France. 2Paris Descartes University, Sorbonne Paris Cité-Medical School, Paris, France. 3INSERM U970, Paris Cardiovascular Research Center, Paris, France. 4Emergency Department, Cochin University Hospital, Hopitaux Universitaires Paris Centre, AP-HP, Paris, France. 5Cardiology Department, Cochin University Hospital, Hopitaux Universitaires Paris Centre, AP-HP, Paris, France. 6SAMU 75, Necker University Hospital, AP-HP, Paris, - - 2014
Determinants of outcome and long-term survival are unknown in elderly patients successfully resuscitated after out-of-hospital cardiac arrest. Our aim was to identify factors associated with short- and long-term neurologic outcome in such patients. Retrospective cohort study. Tertiary hospital in Paris, France. Patients aged over 75 admitted in our ICU after ...
Errando C L CL Servicio de Anestesiología, Reanimación y Tratamiento del Dolor, Consorcio Hospital General Universitario de Valencia, Valencia, Spain. Electronic address: - - 2014
Single shot spinal anesthesia is used worldwide for hip fracture repair surgery in the elderly. Arterial hypotension is a frequent adverse effect. We hypothesized that lowering local anesthetics dose could decrease the incidence of arterial hypotension, while maintaining quality of surgical anesthesia. In a randomized double blinded study, 66 patients ...
Bjerke Trine T Digestive Disease Center, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark, - - 2014
We report the clinical and anal manometric results of elderly patients treated with laparoscopic ventral rectopexy (LVR) for full-thickness rectal prolapse. From March 2009 to June 2012, patients were consecutively included. A modified laparoscopic Orr-Loygue procedure with posterior mobilisation was used. The patients were evaluated preoperatively, 2 months postoperatively and after ...
Lee Ling Hong LH Ling Hong Lee, Aravind Desai, Specialist Registrar, Trauma and Orthopaedics, Northern Deanery, Newcastle Upon Tyne, NE12 8RF, United - - 2014
Shoulder replacement in cuff tear arthropathy (CTA) is an unsolved challenge. CTA poses a soft tissue deficiency in an arthritic glenohumeral joint which the anatomical total shoulder replacement and hemiarthroplasty cannot reliably provide stability, range of movement, function or satisfactory long term outcome. In the past two decades since the ...
Oishi Hidenori H Department of Neuroendovascular Therapy, Juntendo University School of Medicine, Tokyo, - - 2014
We report the results of endosaccular coil embolization of asymptomatic unruptured intracranial aneurysms (UIAs) in elderly patients (≥65 years). There were 375 elderly patients with 400 asymptomatic UIAs. Patients were divided into two groups: group A included patients aged 65-74 years and group B patients aged ≥75 years. Endovascular procedures were completed ...
Bircan Huseyin Yuce - - 2014
Surgical procedures with curative or palliative intentions in subjects aged over 70 represent a colorectal surgical challenge due to the issue they raise: Benefits versus increased morbidity. In this study, we proposed to compare the impact of surgery with the surgical intervention short-term results and analyze the factors that may ...
Barsoum Emad A EA Department of Medicine, Staten Island University Hospital, Staten Island, NY, - - 2014
Ischaemic heart disease is the leading cause of death in the elderly population. Coronary artery bypass graft (CABG) surgery via sternotomy remains the standard of care for patients with multivessel coronary artery disease (CAD). Minimally invasive cardiac surgery (MICS)-CABG via left thoracotomy has been used as an alternative to sternotomy. ...
Conti D D Anaesthesia and Intensive Care Unit, Santa Maria Annunziata Hospital, Florence, - - 2014
Patient sex is known to influence the response to general and regional anaesthesia and recovery after surgery. However, most studies come from analyses carried out on middle-aged patients. As most of the patients admitted to the post-anaesthesia recovery room in our institution are elderly, we took the opportunity to investigate ...
Tang Yuan-Zhang YZ From the *Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing; and †Department of anesthesiology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, - - 2014
The incidence of trigeminal neuralgia (TN) in elderly patients is higher. However, for those with poor fitness, the optimal surgical treatment for those refractory to medical treatment is controversial. The aim of current study was to investigate the long-term outcome of computed tomography (CT)-guided percutaneous radiofrequency thermocoagulation (PRT) for 304 ...
Senbaklavaci O O Department of Cardiothoracic and Vascular Surgery, Johannes Gutenberg University, Mainz, - - 2014
Abstract The aim of this study was to evaluate the impact of chronic obstructive pulmonary disease (COPD) on the perioperative morbidity and mortality after lobar lung resection for non-small cell lung cancer (NSCLC) in patients aged 70 years and older. The medical records of 73 patients ≥70 years who underwent ...
Drews Tanja T From the Department of Anaesthesiology and Surgical Intensive Care Medicine, Campus-Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany *Both Tanja Drews and Martin Franck contributed - - 2014
Posttraumatic stress disorder (PTSD) may appear after hospitalisation for surgery with general anaesthesia in elderly patients. Prevalence and risk factors in this setting are unknown. Postoperative delirium could be a risk factor. The purpose of this study was to identify the prevalence of, and risk factors for, PTSD 3 months ...
Park Chan Hyuk CH Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South - - 2014
Little is known about the clinical and oncologic outcomes of endoscopic submucosal dissection (ESD) compared with surgery in elderly patients with early gastric cancer (EGC). To evaluate the clinical and oncologic outcomes of ESD compared with surgery in elderly patients with EGC of an expanded indication. Retrospective study with propensity-matched ...
Fiorelli Alfonso A Department of Thoracic Surgery, Second University of Naples, Naples, - - 2014
Background The aim of the study was to evaluate the influence of nutritional status on outcome of elderly patients resected for lung cancer. Materials and Methods A total of 117 consecutive patients aged ≥ 70 years undergoing lung cancer resection were enrolled. In addition to routine preoperative evaluations, other variables such as body mass ...
Feliu J J Hospital Universitario La Paz, 28046 Madrid, - - 2014
Background:Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the efficacy and safety of bevacizumab plus XELOX, followed by bevacizumab plus capecitabine in elderly patients with mCRC.Methods:Patients aged ⩾70 years with Eastern ...
Hamel-Desnos C C French Society of Phlebology, Paris, France - - 2014
To investigate the tolerance and safety of thermal ablation (TA), consisting of radiofrequency or endovenous laser (EVLA) of saphenous veins (SV) in elderly (group 1 ≥75 years), compared with a control group (group 2 <75 years). An Observational multicenter-prospective study was conducted, under the aegis of the French and Swiss ...
Wong Chih M CM BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Clydebank, Glasgow, UK - - 2014
Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients. Patients were stratified into six age ...
Wang Linlin L Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, People's Republic of - - 2014
We investigated whether daily supplementation with low-dose B vitamins in the healthy elderly population improves the Framingham risk score (FRS), a predictor of cardiovascular disease risk. Between 2007 and 2012, a double-blind randomized controlled trial was conducted in a rural area of North China. In all, 390 healthy participants aged ...
Wie Seong-Heon SH Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of - - 2014
Aminoglycosides may serve as fluoroquinolone-sparing or cephalosporin-sparing agents if the clinical effectiveness of aminoglycoside monotherapy is demonstrated. The purposes of this study were to investigate the clinical efficacy of gentamicin as an initial empirical antimicrobial agent and to evaluate the effects of gentamicin resistance on clinical outcomes in women with ...
Schmidt J F JF Copenhagen Centre for Team Sport and Health, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Department of Cardiology, Gentofte Hospital, Hellerup, - - 2014
The study examined the effects of 1 year of football or strength training on cardiovascular function in 65- to 75-year-old men. Twenty-six untrained men (age: 68.2 ± 3.2 years) were randomized to football training (FTG; n = 9), strength training (STG; n = 9), or control (CG; n = 8). In FTG, left ventricular (LV) internal diastolic diameter, ...
Zhang Yan Y 1 Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou, China - - 2014
Abstract Objective: To retrospectively evaluate the safety and feasibility of endoscopic submucosal dissection (ESD) for the treatment of early gastric cancer (EGC) in elderly patients ≥75 years of age. Patients and Methods: One hundred seventy-one patients (187 lesions) treated with ESD from January 2010 to September 2013 were enrolled in ...
Son Doo Kyung DK Department of Neurosurgery, Pusan National University Yangsan Hospital, Yangsan, - - 2014
The purpose of this study is to evaluate clinical and radiological outcomes analysis of the laminoplasty in the elderly patients, and to compare with the non-elderly patients. A retrospective study of the short term result in patients who had treated with the laminoplasty for cervical spondylotic myelopathy (CSM) was performed. ...
Takama Takehiro T Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, - - 2014
The incidence of gastric cancer has been increasing among elderly persons in Japan. This study aimed to clarify risk factors for postoperative complications in oldest old patients with gastric cancer. One-hundred ninety patients more than 75 years old with gastric cancer underwent gastrectomy between 2000 and 2011. Patients were classified ...
Capelli Debora D Hematology Department, University of Ancona, Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona, Via Conca 71, 60126 Torrette di Ancona - - 2014
We prospectively evaluated two post-consolidation strategies, administered according to the mobilization outcome, in 72 AML fit elderly patients, achieving CR after the 1st high-dose Cytarabine-based induction. Autologous Stem Cell Transplantation (ASCT) was performed in patients collecting ≥3x10(6) CD34+/kg and low-dose Gemtuzumab-Ozogamicin (GO) in poor mobilizers (collecting<3x10(6) CD34+/kg). Fifty-five patients (76,3%) ...
Kimata Ryoji R Department of Urology, Nippon Medical School, Musashi Kosugi Hospital, Kanagawa, Japan; Department of Urology, Kitamurayama Hospital, Yamagata, - - 2014
To investigate whether the insertion of a thermoexpandable metallic prostate stent (Memokath) facilitates the removal of Foley catheters in elderly patients ineligible for urethral obstruction surgery because of the potential complications involved in long-term catheter management. A total of 37 male patients (mean age 79.8 ± 6.2 years) ineligible for surgery under ...
Pettinari Matteo M Department of Cardiac Surgery, Ziekenhuis Oost Limburg, Genk, - - 2014
Bilateral internal thoracic artery (BITA) grafting is extensively underused in coronary artery bypass graft surgery and it is mostly preserved for patients under the age of 70. The purpose of the present study was to compare outcomes in propensity score-matched patients aged 70 years or greater using a BITA, with ...
Yanagisawa Ryoji R Division of Cardiology, Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, - - 2014
Percutaneous transluminal pulmonary angioplasty (PTPA) is a recently developed catheter-based therapy for chronic thromboembolic pulmonary hypertension (CTEPH). The aim of the present study was to investigate the safety and efficacy of PTPA in elderly patients with CTEPH. In all, 257 PTPA sessions in 70 patients (median age 63years) were analyzed. ...
Aguirre Jason J Case Western Reserve University School of Medicine, Cleveland, - - 2014
Transapical transcatheter aortic valve replacement (TA-TAVR) is a viable treatment option for selected high-risk elderly patients. We analyzed the 30-day mortality and perioperative complications, focusing on the "learning curve" since our first TA procedure in 2007. We also introduce unique cases, demonstrating new possibilities for alternate access sites and concurrent ...
Prudon I I Department of Anesthesiology, Nijmegen, The Netherlands - - - 2014
Is gait speed an incremental predictor for mortality and/or major morbidity in combination with EuroSCORE II? A single center prospective study cohort of 150 patients, 70 years or older, undergoing cardiac surgery between August 2012 and April 2013. Slow gait speed was defined as a time taken to walk 5 ...
Höke Ulas U From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands - - 2014
Limited data are available on efficacy, safety, and long-term prognosis after cardiac resynchronization therapy (CRT) in elderly patients. We aimed at evaluating the effect of CRT, device-related adverse events, and long-term outcome after CRT among elderly patients. A total of 798 CRT recipients (208 elderly: age, ≥75 years; 590 nonelderly: ...
Shoji Hirotaka H Gerodontology and Oral Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, - - 2014
Several reports have recently been published regarding dysphagia in very elderly patients, and centenarian dysphagia patients have become more common in Japan. The aim of this study was to assess the prognosis of dysphagia in very elderly patients. Participants were 24 centenarian dysphagia patients. For each patient, we collected information ...
Krenk Lene L From the *Section of Surgical Pathophysiology and †Department of Anesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen; ‡The Lundbeck Centre for Fast-Track Hip and Knee Arthroplasty, Copenhagen; §Department of Orthopaedic Surgery, Holstebro Hospital, Holstebro; ‖Department of Orthopaedic Surgery, Gentofte Hospital, Gentofte; ¶Department of Orthopaedic Surgery, Århus University Hospital, Århus; and #Department of Anesthesia, Centre of Head and Orthopaedics, University Hospital of Copenhagen, Copenhagen, - - 2014
Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in as many as 20% of patients, elderly patients may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. ...
Park Sang Hi SH Department of Anesthesiology and Pain Medicine, Chungbuk National University College of Medicine, Cheongju, - - 2014
As the number of elder patients grows, spinal anesthesia for such patients are increasing significantly. Any effort is needed to use the least anesthetic drug for maintaining the anesthesia while avoiding hazards of cardio-pulmonary complications. American Society of Anesthesiologists physical status classification I and II, Forty five elderly patients (≥ ...
Brown Charles H CH 4th From the *Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions; and †Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, - - 2014
Low intraoperative Bispectral Index (BIS) values may be associated with increased mortality. In a previously reported trial to prevent delirium, we randomized patients undergoing hip fracture repair under spinal anesthesia to light (BIS >80) or deep (BIS approximately 50) sedation. We analyzed survival of patients in the original trial. Among ...
Yusuf Imran H IH Department of Ophthalmology, Oxford Eye Hospital, Headley Way, Headington , Oxford , OX3 9DU United Kingdom - - 2014
Abstract Introduction: Toxoplasma chorioretinitis is a leading cause of infectious posterior uveitis worldwide. Methods: We report an atypical presentation of Toxoplasma chorioretinitis presenting after uneventful cataract surgery in an 81-year-old male, with known hypernephroma and rheumatoid arthritis, treated with prednisolone and methotrexate. Results: He was treated for acute retinal necrosis ...
Oh Sung-Hee - - 2014
This study aimed to investigate national prescription trends of benzodiazepines (BZD) for adults between 2007 and 2011 using Health Insurance Review and Assessment Service (HIRA) database in South Korea. Data analysis was performed by claim unit or patient unit. For the analysis of patient unit, each claim was merged by ...
Tonozuka Ryosuke R Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan, - - 2014
Minimally invasive interventions for choledocholithiasis are preferable in elderly patients because they tend to have multiple underlying disorders or a decreased activity of daily living. Endoscopic sphincterotomy and endoscopic papillary balloon dilation have been recognized as first-line treatments for choledocholithiasis excluding difficult cases such as large stones or multiple stones. ...
Milano Aldo Domenico AD Division of Cardiac Surgery, Department of Surgery, University of Verona Medical School, Verona, - - 2014
To evaluate if pulsatile cardiopulmonary bypass (CPB) has any protective influence on renal function in elderly patients undergoing aortic valve replacement (AVR). Forty-six patients (≥75 years old) with aortic valve stenosis underwent AVR with either pulsatile perfusion (PP) or non-pulsatile perfusion (NP) during CPB. Haemodynamic efficacy of the blood pump ...
Kim Ki-Han - - 2014
With an increase in life expectancy, very elderly patients are presenting with gastric cancer more commonly than ever. The present study retrospectively analyzed the surgical outcomes of laparoscopy-assisted gastrectomy for gastric cancer in the young, elderly, and very elderly age groups. The study group consisted of 1,055 patients who underwent ...
Li Linda T LT *Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX †VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, TX ‡Department of Medicine, Baylor College of Medicine, Houston, TX §Operative Care Line, Michael E. DeBakey VA Medical Center, Houston, - - 2014
To characterize transitional care needs (TCNs) after colorectal cancer (CRC) surgery and examine their association with age and impact on overall survival (OS). TCNs after cancer surgery represent additional burden for patients and are associated with higher short-term mortality. They are not well-characterized in CRC patients, particularly in the context ...
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