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Watts John A - - 2011
Pulmonary embolism (PE) causes pulmonary hypertension by mechanical obstruction and constriction of non-obstructed vasculature. We tested if experimental PE impairs pulmonary vascular endothelium-dependent dilation via activation of arginase II. Experimental PE was induced in male Sprague-Dawley rats by infusing 25μm microspheres in the right jugular vein, producing moderate pulmonary hypertension. ...
Zeng Z Z Department of Mechanical Engineering and Materials Sciences, University of Pittsburgh, Pennsylvania, 15261, - - 2011
Animal models provide a mechanism for fundamental studies of the coupling between hemodynamics and pathophysiology in diseases such as saccular aneurysms. In this work, we evaluated the capability of an elastase-induced saccular aneurysm model in rabbits to reproduce the anatomic and hemodynamic features typical for human intracranial aneurysms. Saccular aneurysms ...
Wideman Robert F RF - - 2011
Idiopathic pulmonary arterial hypertension (IPAH) is a disease of unknown cause that is characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance attributable to vasoconstriction and vascular remodeling of small pulmonary arteries. Vascular remodeling includes hypertrophy and hyperplasia of smooth muscle (medial hypertrophy) accompanied in up to 80% of ...
Safdar Zeenat - - 2011
Pulmonary arterial hypertension is a progressive, fatal disease characterized by elevated pulmonary arterial pressure ≥25mmHg and normal pulmonary capillary wedge pressure ≤15mmHg. Physiological features of pulmonary arterial hypertension are characterized clinically by the presence of pre-capillary pulmonary hypertension not caused by other conditions such as lung diseases or chronic thromboembolic ...
Bass John L - - 2011
OBJECTIVES:: This study assessed the feasibility and efficacy of implanting a new miniaturized nitinol device to occlude the patent ductus arteriosus (PDA) in a newborn porcine model. BACKGROUND:: Transcatheter device closure is the standard of care for PDA in older children and adults. Currently available technology is not designed for ...
Turpie A G G - - 2011
Thromboembolic disorders are major causes of morbidity and mortality. It is well-recognised that the pathogenesis is different for arterial and venous thrombosis; however, both involve coagulation activation. Anticoagulants are used for the prevention and treatment of a wide variety of thromboembolic and related conditions. Agents with anti-inflammatory properties in addition ...
Chan Andrew L - - 2011
Idiopathic pulmonary fibrosis (IPF) is a disease of the elderly with a mean age at presentation of 66 years. It is the most common type of idiopathic lung fibrosis, and the most lethal, with a median survival of 3 to 5 years after diagnosis. Abnormalities in fibroblast and humoral response mechanisms may ...
Onal Mehmet Bulent - - 2011
cerebral vasospasm (CVS) is one of the most considerable complications of subarachnoid hemorrhage (SAH). The aim of this study was to assess and to compare the ability of intrathecal dotarizine and nimodipine to prevent and treat vasospasm in a rabbit model of subarachnoid hemorrhage. thirty male New Zealand white rabbits ...
Vaglio Augusto - - 2011
Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic periaortitis may also involve other arteries and present with features of auto-immune diseases. ...
Clevert D A - - 2011
Purpose: To evaluate neovascularisation within carotid atherosclerotic plaques with contrast enhanced ultrasound. Methods: We used contrast-enhanced ultrasound to examine 33 patients with carotid atherosclerotic plaques. Plaque size and echogenicity were analyzed and we correlated neovascularization within the plaques. Results: There were 41 atherosclerotic plaques, 27 plaques enhanced after the injection ...
Lazoura Olga - - 2011
ABSTRACT Purpose: To develop a new rabbit model of arterial stenosis using endovascular radiofrequency (RF) energy. Materials and Methods: Ten rabbits were used for multiple endovascular RF applications to the aorta and left common carotid artery through the Habib™ VesCoag™ catheter. Angiography and color Doppler ultrasound were used to assess ...
Civelek Erdinc - - 2011
the aim of this study was to assess and to compare the ability of intrathecal flunarizine and nimodipine to prevent vasospasm in a rabbit model of subarachnoid hemorrhage (SAH). forty male New Zealand white rabbits were allocated into 5 groups randomly. The treatment groups were as follows: (1) control (no ...
Lefèvre Arnaud - - 2011
Patients with ulcerative colitis are at increased risk for venous thrombosis. We report herein the case of a 28-year-old woman who developed multiple intraabdominal venous thrombosis, including partial Budd-Chiari syndrome in association with intracranial venous thrombosis and pulmonary embolism during the relapse of a known ulcerative colitis. Multidetector-row computed tomography ...
Skóra Jan - - 2011
In order to determine the processes arising during the healing in vascular grafts the following experiment was desinged in 16 dogs. The animals underwent implantation of unilateral bypass aorto-femoral (straight prosthesis from politetrafluoroethylrne--PTFE). After the 6 months all the animals sacrificed and vascular grafts were dissected and exam in electron ...
Dasari Papa - - 2011
A 30-year-old woman, para 2, who underwent an uneventful repeat elective lower segment caesarean section with sterilisation presented on the 23rd postnatal day to our Obstetric Emergency department with profuse bleeding per vaginum. She had a similar bout of bleeding on the 19th postnatal day and was treated elsewhere with ...
Chiang Terrance - - 2011
Stroke is the most common fatal neurological disease in the United States. The majority of strokes (88%) result from blockage of blood vessels in the brain (ischemic stroke). Since most ischemic strokes (~80%) occur in the territory of middle cerebral artery (MCA), many animal stroke models that have been developed ...
Blanco Ignacio - - 2011
Up to now alpha 1-antitrypsin (AAT) augmentation therapy has been approved only for commercial use in selected adults with severe AAT deficiency-related pulmonary emphysema (i.e. PI*ZZ genotypes as well as combinations of Z, rare and null alleles expressing AAT serum concentrations <11 μmol/L). However, the compassionate use of augmentation therapy ...
Moatti Zoe Z Obstetrics and Gynaecology Department, Barnet General Hospital, London, UK. - - 2011
A 29-year-old woman (gravida 1, para 1) had an uneventful first pregnancy and a delivery by emergency caesarean section at term. The caesarean section was complicated by a massive obstetric haemorrhage of 5000 ml. After closure, an immediate re-laparotomy was indicated due to heavy vaginal bleeding. The site of bleeding ...
Sharma Ankur M AM College of Medicine, University of Saskatchewan, Saskatoon, SK, - - 2011
Postpartum hemorrhage is a major cause of maternal mortality. Though uncommon, uterine artery pseudoaneurysm can follow uterine dilatation and curettage (D + C) and needs to be considered in the differential diagnosis. This 30-year-old G1P1 woman presented with right upper quadrant pain and vaginal bleeding. She was afebrile but her ...
Hiraki Takao T Takao Hiraki, Department of Radiology, Okayama University Medical School, Shikatacho 2-5-1, Okayama 700-8558, - - 2010
Dr. Takao Hiraki is a scientist carrying out interventional radiology research in the Department of Radiology at Okayama University Medical School, Japan. He has conducted animal and human clinical studies on interventional radiology for various conditions. For example, he clarified the hepatic hemodynamic changes caused by hepatic venous occlusion. He ...
Reynolds Paul N - - 2011
The management and understanding of pulmonary arterial hypertension (PAH) has undergone something of a revolution in the last 10 years, with new pharmacological agents entering routine clinical practice and significantly improving outcomes. Nevertheless many patients ultimately progress, and additional new treatment approaches are needed. There is now greater understanding of ...
Chaib E - - 2011
The swine is an essential model for carrying out preclinical research and for teaching complex surgical procedures. There is a lack of experimental models describing anatomical and surgical aspects of total pancreatectomy in the pig. The experiments were performed on 10 white male swine weighing 27-33 kg. The animals were ...
Schwartz Arthur E - - 2010
Hypothermia is known to provide neuroprotection from focal ischemia. However, lethal cardiovascular complications resulting from total body cooling have greatly restricted hypothermia as a therapy for stroke. This study determined whether selective cerebral cooling induced after reversible cerebral artery occlusion would decrease the infarct volume. Under general anesthesia, 8 baboons ...
Xavier S G - - 2011
Thrombotic complications are a main concern in patients with myeloproliferative neoplasms. Recently, a gain-of-function mutation of the gene encoding the JAK2 tyrosine kinase that results in a valine-to-phenylalanine substitution at position 617 (V617F) has been described. Since the description of the JAK2-V617F mutation and its finding in patients with splanchnic ...
Bălăceanu Alice - - 2010
During the virus C infection the presence of cirrhosis is the major risk factor for the development of hepatocellular carcinoma. In the absence of cirrhosis the estimated prevalence hepatocellular carcinoma ranged from 6.7% to 50.1%. We present the case of a 64 year-old-man admitted to the hospital with 3-days history ...
Ryerson Lindsay M - - 2010
We present the clinical course and management of two infants with idiopathic infantile arterial calcification. Both had coronary artery involvement and presented with ischaemic cardiac failure. Neither responded well to conventional therapy with inotropic agents, glyceryl trinitrate, diuretic and mechanical ventilation, nor to short-term biphosphonates. One was treated with levosimendan ...
Detering Sabine M - - 2011
Central venous lines are of particular importance in seriously ill children that require parenteral nutrition, chemotherapy, or other medications. The jugular or subclavian veins are ordinarily used for primary access. Alternatives include the femoral veins, the intercostal veins, and transhepatic approaches. If the use of these standard sites of placement ...
de Oliveira Ivanilson Alves - - 2011
Experimental saccular aneurysms can be created with surgical techniques of the arterial wall or by injecting pancreatic elastase. Papain is an enzyme with properties similar to those of elastase, and it has not been tested for this purpose. The objective of this study was to determine whether papain produces saccular ...
Zwirner Kerstin - - 2010
In acute liver failure (ALF) hyperammonemia plays a mayor role in the pathogenesis of hepatic encephalopathy (HE) but does not always correlate with the severity of mental deterioration and intracranial pressure (ICP). The aim of our study was to evaluate the association with extracellular brain ammonia, ICP and the therapeutical ...
Bai Yuan - - 2010
Pulmonary regurgitation leads to progressive right ventricular dysfunction, susceptibility to arrhythmias, and sudden cardiac death. Percutaneous valve replacement has been developed in recent years, providing patients with an alternative option. Percutaneous pulmonary valve replacement has been recently introduced into clinical practice. The goal of this study was to evaluate the ...
Rasmussen Randall L - - 2010
Tunneled dialysis catheters (TDC) become dysfunctional because of placement problems, infection, thrombosis, and fibrin sheath formation. Occasional patients who are catheter dependant develop frequent catheter dysfunction because of thrombosis or thrombosis associated with fibrin sheath formation. This article attempts to define which dysfunctional catheters because of thrombosis and thrombosis associated ...
Kundu Somenath - - 2010
Arteriovenous malformations of the lung are rare pulmonary vascular disorders which can suddenly lead to life threatening complications. Haemothorax due to rupture of a pulmonary arteriovenous malformation (PAVM) is very rare. We report here a case of a 39 year-old lady who presented with an acute onset of shortness of ...
Kansal Mayank M - - 2011
In patients with hypertrophic obstructive cardiomyopathy and dynamic left ventricular outflow tract obstructions, an additional fixed obstruction may uncommonly coexist. In these situations, flow through the aortic valve is usually delayed but typically still throughout the entire ejection period. We describe a case of marked reduction in aortic flow during ...
Whittaker Carrie - - 2010
Cardiopulmonary bypass (CPB) protocols of the baboon (Papio cynocephalus anubis) are limited to obtaining experimental data without concern for long-term survival. In the evaluation of pulmonary artery tissue engineered heart valves (TEHVs), pediatric CPB methods are adapted to accommodate the animals' unique physiology enabling survival up to 6 months until ...
Buch Mamta H - - 2010
Atherosclerosis is a diffuse, systemic disorder of the large and medium-sized arterial vessels, affecting the coronary, cerebral and peripheral circulation. Chronic inflammatory processes are the central pathophysiological mechanism largely driven by lipid accumulation, and provide the substrate for occlusive thrombus formation. The clinical sequelae of acute arterial thrombosis, heart attack ...
Espinosa Gerard - - 2010
Behçet's disease is a systemic vasculitis characterised by recurrent mouth and genital ulcers and uveitis. About 25% of patients suffer from vascular involvement. We describe a patient with Behçet's disease who suffered recurrent pulmonary embolism and developed severe chronic thromboembolic pulmonary hypertension. The patient was successfully treated with pulmonary endarterectomy ...
Navarro Fábio Binhara - - 2010
The cryopreserved homograft is a good valve substitute due attributes like excellent hemodynamics, low incidence of thromboembolic events, infection resistance and good mid-term durability. However, progressive homograft degeneration and fibrocalcification may occur, particularly in the childhood and young adults. Their antigenicity triggers an immunological reaction that plays an important role ...
Chang Dong Woo - - 2010
In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental aneurysm and selective angiography on the common carotid artery in rabbits and to determine the size of experimental aneurysm after ...
Scacciatella Paolo - - 2010
Acute coronary syndrome because of left main coronary artery (LMCA) occlusion is a catastrophic event associated with poor prognosis and high in-hospital mortality. The most common cause for LMCA thrombosis is an atherosclerotic plaque rupture with subsequent superimposed thrombus formation. If this cause is excluded, rare causes should be investigated ...
Heuser Cara C - - 2010
BACKGROUND: Idiopathic infantile arterial calcification is a rare disorder that often results in fetal or neonatal demise. Few reports have detailed an early diagnosis, complete antenatal and postnatal imaging, and postmortem findings. CASE: A patient presented at 33 weeks of gestation with hydrops fetalis. Idiopathic infantile arterial calcification was diagnosed ...
Slezák P - - 2010
Wire myograph is a device for the in vitro investigation of both, active and passive properties of arteries. Arteries from a variety of animal species, pathological states, and vascular beds were investigated using this method. We focus on the normalization procedure which is aimed to standardize experimental settings and, in ...
Olopade James O - - 2010
The report of the occurrence of additional renal arteries in domestic animals is rare in the literature. We report a case of an additional renal artery in the left kidney found in a Red Sokoto goat cadaver. The additional renal artery originated from the abdominal aorta 3.80 cm cranial to ...
Yamakoshi Ken-Ichi - - 2010
This paper discussed physiological measurement instrumentation for ambulatory/wearable physiological monitoring, cardio-pulmonary monitoring, activity monitoring, and biochemical monitoring. Future aspects also were discussed.
Chen Chao-Chin - - 2009
We presented an unique case of apical hypertrophic cardiomyopathy concomitant with subaortic obstruction, apical sequestration, and valvular aortic stenosis. The echocardiographic findings were conflicting and characterized by quadruple pressure gradients within the left ventricle, which were compatible with the findings of 64-slice computed tomography imaging and cardiac catheterization.
Brouwers A G A - - 2009
Nitric oxide (NO) is an important mediator of biological functions. Absence or shortage of NO plays a role in the pathogenesis of both hypertrophic pyloric stenosis and persistent pulmonary hypertension. We present a neonate diagnosed with pulmonary hypertension after birth caused by meconium-aspiration syndrome eventually treated with extracorporal membrane oxygenation ...
Mottaghi Hassan - - 2009
Pulmonary arteriovenous malformation (PAVM) is a rare condition in which there is abnormal connection between pulmonary arteries and veins. The disorder usually appears in late childhood or early adult life, with dyspnea on exertion, clubbing or cyanosis. We present two patients with severe cyanosis and their work-up to diagnosis of ...
Mottaghi Hassan - - 2009
Pulmonary arteriovenous malformation (PAVM) is a rare condition in which there is abnormal connection between pulmonary arteries and veins. The disorder usually appears in late childhood or early adult life, with dyspnea on exertion, clubbing or cyanosis. We present two patients with severe cyanosis and their work-up to diagnosis of ...
Stoica L - - 2008
Surgery of the hypertrophic cardiomyopathy remains controversial. The safest procedure and the simples procedure is the mitral valve replacement. Septal myomectomy is difficult because of the poor surgical exposure and complications: incomplete resection, complete heart block, ventricular septal defect. A 56 years old man with hypertrophic cardiomyopathy, double coronary stenosis ...
Sotgia Barbara B Department of Clinical Physiopathology-Nuclear Medicine Unit, Azienda Ospedaliera Universitaria Careggi, Florence, - - 2008
To clarify the spatial relationship between coronary microvascular dysfunction and myocardial fibrosis in hypertrophic cardiomyopathy (HCM), we compared the measurement of hyperemic myocardial blood flow (hMBF) by PET with the extent of delayed contrast enhancement (DCE) detected by MRI. In 34 patients with HCM, PET was performed using (13)N-labeled ammonia ...
Wykrzykowska Joanna J - - 2008
Among the aging population, hypertrophic cardiomyopathy and aortic stenosis often coexist. Distinguishing the contributions of these two pathologies to the patient's symptoms of congestive heart failure, chest pain and syncope is often challenging. Furthermore, the appropriate treatment is highly dependent on a clear determination of pathophysiology. Here, we present a ...
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