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Sheffield W P WP Department of Pathology and Molecular Medicine, HSC 4N66, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, - - 2014
The leech protein hirudin is a potent natural thrombin inhibitor. Its potential as an antithrombotic agent is limited by its promotion of bleeding. We attempted to modify this profile by positioning albumin and a plasmin cleavage site on its N-terminus, in recombinant protein HSACHV3 [comprising hirudin variant 3 (HV3) fused ...
Chettimada Sukrutha S Dana-Farber Cancer - - 2014
Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-year life expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and remodeling of the pulmonary arteries. We now know that pulmonary arterial remodeling is a consequence of hyperplasia and hypertrophy of pulmonary artery smooth muscle (PASM), ...
Grytsan Andrii - - 2014
We propose a model for abdominal aortic aneurysms that considers the wall (solid), the blood (fluid) and the wall growth within a three-dimensional finite element framework. The arterial wall is considered as a thick-walled nonlinearly elastic circular cylindrical tube consisting of two layers corresponding to the media-intima and adventitia, where ...
Zwierzak Iwona I Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield - - - 2014
To quantify variability of in vitro and in vivo measurement of 3D device geometry using 3D and biplanar imaging. Comparison of stent reconstruction is reported for in vitro coronary stent deployment (using micro-CT and optical stereo-photogrammetry) and in vivo pulmonary valve stent deformation (using 4DCT and biplanar fluoroscopy). Coronary stent ...
Pei H H Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100037, People's Republic of - - 2014
In this study the role of microRNA-145 expression in ascending aortic aneurysm wall media remodeling was examined. Aortic wall samples were obtained from 10 patients who had undergone surgery for ascending aortic aneurysm. Control aortic tissue samples were obtained from 10 patients who had undergone coronary artery bypass graft. The ...
Kessler Alexander A From the Department of Imaging Sciences, University of Rochester Medical Center, Rochester, - - 2014
A 53-year old woman suspicious for having pulmonary embolism on enhanced chest CT was proven to have metabolically active tumor in her pulmonary arteries on F-FDG PET/CT. Through biopsy and surgery, this turned out to be a pulmonary artery angiosarcoma. This case demonstrates that PET/CT is very useful in differentiating ...
Luo Ying Y From the Department of Pathology, Xijing Hospital (Y.L., M.-Q.D., Z.-C.L.), Department of Pathology and Pathophysiology (Y.L, H.-Y.D., B.Z., Y.L., M.-Q.D., Z.-C.L.), Lung Injury and Repair Center (Y.L., H.-Y.D., B.Z., Y.L., M.-Q.D., Z.-C.L.), and Department of Respiratory, Xijing Hospital (Z.F.), Fourth Military Medical University, Xi'an, People's Republic of China; and Department of Pathophysiology and High Altitude Physiology, Third Military Medical University, Chongqing, China - - 2014
Activation of pulmonary adventitial fibroblasts plays a key role in the pulmonary vascular remodeling in hypoxic pulmonary hypertension. Previous studies showed that miRNAs participated in the regulation of fibroblast activation. This study explored the role of miR-29 in the activation of pulmonary adventitial fibroblasts and the therapeutic potential in hypoxic ...
Hempenstall Allison A School of Health Science, Bond University, Robina, - - 2014
The effects of the Pseudomonas aeruginosa virulence factor pyocyanin (PCN) on contractile function of porcine coronary arteries was investigated in vitro. Artery rings (5 mm) were suspended in organ baths containing Krebs solution for the measurement of isometric tension. The effect of PCN on resting and precontracted coronary arteries was ...
Sousa Joana B JB REQUIMTE/FARMA, Laboratório de Farmacologia, Departamento de Ciências do Medicamento, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal; MedinUP- Centro de Investigação Farmacológica e Inovação Medicamentosa, - - 2014
The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact and denuded) or exhibiting some degree of endothelium dysfunction (spontaneously hypertensive arteries), pre-incubated with [(3)H]-noradrenaline in the presence of enzymes (nitric oxide synthase (NOS); nicotinamide adenine dinucleotide ...
Ishihara Tomoaki T Faculty of Pharmacy, Keio University, Tokyo 105-8512, - - 2014
Prostaglandin I2 (PGI2) and its analogues (such as beraprost sodium, BPS) are beneficial for the treatment of pulmonary arterial hypertension (PAH). The encapsulation of BPS in nanoparticles to provide sustained release and targeting abilities would improve both the therapeutic effect of BPS on PAH and the quality of life of ...
Marbacher Serge S From the Department of Neurosurgery, Neurosurgery Research Group, Biomedicum Helsinki, Helsinki University Central Hospital, Helsinki, Finland (S.M., J.F., J.M., P.H., J.H., M.N.); Wihuri Research Institute, Translational Cancer Biology Program, Biomedicum Helsinki (A.A.) and Department of Neurology, Institute of Biomedicine, Experimental MRI Laboratory (U.A.-R.), University of Helsinki, Helsinki, Finland; and Institute of Pathology Laenggasse, Bern, Switzerland (M.v.G.). - - 2014
Aneurysm occlusion by intraluminal thrombus formation is the desired effect of all endovascular treatments. Intraluminal thrombus may, however, recanalize and be absorbed, unless it is infiltrated by cells that turn it into fibrous tissue (neointima). Because ruptured aneurysm walls are characterized by loss of smooth muscle cells, we assessed the ...
Chen Joseph - - 2014
Calcific aortic valve disease is a significant cardiovascular disorder characterized by the formation of calcific nodules on the valve. In vitro assays studying the formation of these nodules were developed and have led to many significant mechanistic findings; however, the biophysical properties of calcific nodules have not been clearly defined. ...
Chen Jiwang J 1 Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, Department of - - 2014
Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of the bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that promotes cell proliferation, migration, and angiogenesis. We aimed to examine whether SphKs and their product, S1P, play a role in the development of pulmonary arterial hypertension (PAH). SphK1(-/-), SphK2(-/-), and ...
Stein Richard A RA From the Division of Cardiology, Department of Medicine (R.A.S., J.S.B.), Division of Vascular Surgery, Department of Surgery (C.B.R., M.A.A., T.R., J.S.B.), Division of Biostatistics, Department of Population Health (Y.G.), New York University Langone Medical Center, New York; and Division of Cardiology, Department of Medicine, University of Colorado School of Medicine and CPC Clinical Research, Aurora - - 2014
Although the relationship between physical activity and coronary heart disease is well characterized, a paucity of data exists on physical activity and vascular disease in other arterial territories. This study examined the prevalence of peripheral artery disease (PAD) and carotid artery stenosis (CAS) in association with physical activity. The association ...
Emrich Fabian C FC From the Department of Cardiothoracic Surgery (F.C.E., H.O., A.R.D., K.P., D.R.M., J.T.C., M.O.M., A.J.P., J.K.C., T.K.K, M.P.F.), Department of Cardiovascular Medicine (H.O., U.R.), Department of Pediatrics (J.K.H., C.M.A, M.R.), Department of Radiology (F.G.B.), and Department of Pathology (A.J.C.), Stanford University, CA; Department of Cardiothoracic Surgery, Heart Center, Leipzig University, Leipzig, Germany (F.C.E., K.P., D.R.M., F.W.M.); and Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan - - 2014
Rupture and dissection of aortic root aneurysms remain the leading causes of death in patients with the Marfan syndrome, a hereditary connective tissue disorder that affects 1 in 5000 individuals worldwide. In the present study, we use a Marfan mouse model (Fbn1(C1039G/+)) to investigate the biological importance of apoptosis during ...
Salomone Salvatore S Department of Clinical and Molecular Biomedicine, Catania University, Catania, Italy. Electronic address: - - 2014
Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S) modulate vascular tone. In view of their therapeutic potential for ocular diseases, we examined the effect of exogenous CO and H2S on tone of isolated rabbit ophthalmic artery and their interaction with endogenous and exogenous NO. Ophthalmic artery segments mounted ...
Odelin Gaëlle G Aix Marseille Université, GMGF UMR_S910, Faculté de Médecine, 27 Bd Jean Moulin 13385, Marseille, France Inserm, U910, Faculté de Médecine, 27 Bd Jean Moulin, 13005, Marseille, - - 2014
Heart valve maturation is achieved by organization of extracellular matrix and distribution of valvular interstitial cells. However, the factors that regulate matrix components required for valvular structure and function are unknown. Based on the discovery of its specific expression in cardiac valves, we aimed to uncover the role of Krox20 ...
Tolva Valerio V Surgical Department, Istituto Auxologico Italiano Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Presidio Ospedaliero Capitanio, Milan, Italy; Dipartimento di Scienze della Salute, University of Milan-Bicocca, Milan, Italy. Electronic address: - - 2014
Restenosis due to intimal hyperplasia is a major clinical problem that compromises the success of angioplasty and endovascular surgery. Resveratrol (RSV) has demonstrated a beneficial effect on restenosis from angioplasty. Unfortunately, the physicochemical characteristics of RSV reduce the practicality of its immediate clinical application. This work proposes an experimental model ...
Gupta Nilesh N Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter Drive, Amarillo, TX-79106, - - 2014
In this study, we tested the hypothesis that a cell permeable peptide, CARSKNKDC (CAR), conjugated nanoerythrosomes (NERs) containing fasudil, a rho-kinase (ROCK) inhibitor, produces prolonged pulmonary preferential vasodilation. CAR conjugated NERs containing fasudil were prepared by hypotonic lysis and extrusion method, optimized for various physicochemical properties in-vitro. The formulations were ...
Kim Jongmin J Yale University School of Medicine, New Haven, CT & Sookmyung Women's University, Seoul, - - 2014
-Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary arterioles, characterized by increased pulmonary arterial pressure and right ventricular failure. The etiology of PAH is complex, but aberrant proliferation of the pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) is thought to play an ...
Nahar Kamrun - - 2014
We have proposed a liposomal delivery system of fasudil - an investigational drug for the treatment of pulmonary arterial hypertension (PAH) - that preferentially accumulates in the pulmonary arterial hypertensive lungs. Liposomal fasudil was prepared by film hydration method and the drug was encapsulated by active loading. Liposome surface was ...
Moran Corey S CS From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia (C.S.M., R.J.J., E.B., J.G.); and Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Queensland, Australia - - 2014
Mounting evidence links osteoprotegerin with cardiovascular disease. Elevated serum and aortic tissue osteoprotegerin are associated with the presence and growth of abdominal aortic aneurysm in humans; however, a role for osteoprotegerin in abdominal aortic aneurysm pathogenesis remains to be shown. We examined the functional significance of osteoprotegerin in aortic aneurysm ...
Su Xianming X 1First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China 2Shaanxi General Hospital of Chinese People's Armed Police Forces, Xi'an 710054, China 3China Resources Sanjiu Medical & Pharmaceutical Co. Ltd, Shenzhen 518110, China 4College of Life Science, Northwest University, Xi'an 710069, China 5Medical College of Xi'an Jiaotong University, Xi'an 710061, - - 2014
Previous studies have found that Danhong injection (DHI), an extensively used herbal extract preparation in China, might be a powerful vasodilator. The aims of the present study were to determine the vascular activity of DHI and its effects on arteries of different sizes. The results showed that DHI significantly inhibited ...
Cushing Leah L The Columbia Center for Human Development, Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, Columbia University, College of Physicians & Surgeons, 630 West 168th Street, BB 8-810, New York, NY 10032, - - 2014
Pulmonary fibrosis is a pathological condition in which lungs become scarred due to the excess extracellular matrix (ECM) deposition and structural alterations in the interstitium of lung parenchyma. Many patients with interstitial lung diseases (ILDs) caused by long-term exposure to toxic substances, chronic infections, or autoimmune responses develop fibrosis. Etiologies ...
Nowicki Kamil W KW From the Departments of Neurosurgery (K.W.N., K.H., B.L.H.), Surgery (Y.H.), Biomedical Engineering (P.S.M.), and Molecular Genetics and Microbiology (E.W.S.), University of Florida, - - 2014
Cerebral aneurysms are thought to develop at locations of hemodynamic shear stress, via an inflammatory process. The molecular mechanism that links shear stress to inflammation, however, is not completely understood. Progress in studying this disease is limited by a lack of a suitable in vitro model. To address this, we ...
Becker Mike O MO Charité University Hospital, Rheumatology and Clinical Immunology, Berlin, Germany ; - - 2014
Objective: Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin-1 (ET-1) and angiotensin II (Ang II) via endothelin receptor type A (ETAR) and angiotensin receptor type-1 (AT1R) activation are implicated in PAH pathogenesis. We hypothesized that stimulating ...
Kruangtip Oraya O Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, - - 2014
Phosphodiesterase (PDE)-5 inhibitors are useful as vasodilators for the treatment of pulmonary arterial hypertension. We aimed to study curcumin analogues for PDE5 inhibitory activity and vasorelaxation of rat pulmonary arteries. Three natural curcuminoids (1-3) and six synthetic analogues (4-9) were tested for PDE5 and PDE6 inhibitory activities using enzymatic radioassay. ...
Ergun Onur O Dışkapı Yildirim Beyazit Training and Research Hospital; Ankara, Turkey - - - 2014
A 64-year-old man was admitted with massive hemoptysis caused by oropharyngeal carcinoma. Angiography revealed active extravasation from the left carotid bulb. Covered stent-graft placement resolved the bleeding, but the patient presented with recurrent hemorrhage two hours later and was treated with another stent-graft.
Moraga Fa F Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte - UCN, Campus Guayacán, Coquimbo, - - 2014
Preliminary studies showed that dorsal artery contraction mediated by acetylcholine (ACh) is blocked with indomethacin in intertidal fish (Girella laevifrons). Our objective was to characterise the cholinergic pathway in several artery vessels of the G. laevifrons. Afferent and efferent branchial, dorsal and mesenteric arteries were dissected of 6 juvenile specimens, ...
Sousa Joana Beatriz JB REQUIMTE/FARMA, Departamento de Ciências do Medicamento, Laboratório de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal; MedInUP- Centro de Investigação Farmacológica e Inovação Medicamentosa, Universidade do Porto, Porto, - - 2014
Increased sympathetic activity has been implicated in hypertension. Adenosine has been shown to play a role in blood flow regulation. In the present study, the endogenous adenosine neuromodulatory role, in mesenteric arteries from normotensive and spontaneously hypertensive rats, was investigated. The role of endogenous adenosine in sympathetic neurotransmission was studied ...
Li Jie - - 2014
C-reactive protein (CRP) is a biomarker of systemic inflammation, which is also associated with pulmonary artery disease. However, the impact of CRP on cell proliferation of the pulmonary arterial wall has been investigated less. We, therefore, examined the effects and potential mechanisms of CRP on proliferation in human pulmonary artery ...
Zelenák K - - 2012
Hemorrhagic complications are usually manifestations of the progress of severe pancreatitis. In major arterial hemorrhage resulting from pancreatic inflammatory disease, visceral angiography is valuable in localizing the site of bleeding, and hemostasis can be achieved by transcatheter arterial embolization. Successful transcatheter embolization of bleeding in the anterior superior pancreaticoduodenal artery ...
Arora Anil - - 2012
Pseudoaneurysms occurring in patients with chronic pancreatitis are associated with significant morbidity and mortality. These pseudoaneurysms occur more commonly in the splenic, pancreaticoduodenal, and gastroduodenal arteries. Upper gastrointestinal bleeding (UGIB) due to pseudoaneurysms in patients with pancreatitis with pseudocyst usually presents as hemosuccus pancreaticus. However, pseudoaneurysm directly perforating the gastrointestinal ...
Fukatsu Kazuhiro - - 2012
Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsatile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized ...
Yang Jae Do - - 2012
To investigate the factors affecting the development of the ligament of Treitz, we examined sagittal and frontal histological sections of 35 human fetuses with a crown-rump length of 100-300 mm (approximately 16-38 weeks of gestation). The retropancreatic fascia consistently extended in a layer behind the pancreatic body and the splenic artery and ...
Rudominer Rebecca - - 2012
A 55-year-old woman was diagnosed with endocarditis involving the aortic valve and resulting in moderate aortic insufficiency. Transesophageal and transthoracic echocardiography demonstrated an unusually accentuated diastolic anterior motion of the anterior mitral valve leaflet toward the interventricular septum. The anterior leaflet remained within a few millimeters of the septum throughout ...
Gürses Cemil - - 2012
A 9-year-old child with a left humerus fracture also had minor skin cuts on the right knee, which were closed with a skin stapler. After 1 week, a medial superior genicular artery pseudoaneurysm developed, which was treated by ultrasound-guided compression. This case illustrates a unique complication of the use of ...
Mitkov Mario - - 2012
Multiple aneurysms involving the celiac axis are extremely rare. Celiac artery aneurysms account for only 4% of all visceral aneurysms with 40% having concomitant aneurysms such as gastroduodenal artery (GDA) aneurysms. Development of a GDA aneurysm is associated with pancreatitis. If a GDA aneurysm ruptures, traditional repair is through open ...
Minamiguchi Hiroki H Hiroki Minamiguchi, Nobuyuki Kawai, Morio Sato, Akira Ikoma, Munehisa Sawa, Tetsuo Sonomura, Shinya Sahara, Kouhei Nakata, Isao Takasaka, Motoki Nakai, Department of Radiology, Wakayama Medical University 811-1 Kimiidera, Wakayama Shi, Wakayama 641-8510, - - 2012
Gastric varices are usually associated with a gastro-renal (G-R) shunt. However, the gastric varices described in this case report were not associated with a G-R shunt. The inflow vessel was the posterior gastric vein and the outflow vessels were the narrow inferior phrenic vein and the dilated cardio-phrenic vein. First, ...
Maclay John D JD ELEGI Colt Laboratory, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. - - 2012
Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation. To investigate whether patients with COPD have evidence of systemic elastin degradation in the skin. The authors measured cutaneous elastin degradation using immunohistochemistry ...
Zhang Qing Q Department of Internal medicine, Clinical Medical college of Yangtze University, Jingzhou 434000, Hubei Province, China. - - 2012
Acute pancreatitis is an inflammatory disease characterized by local tissue injury which can trigger a systemic inflammatory response. So vascular complications of pancreatitis are a major cause of morbidity and mortality. Pulmonary embolism in acute pancreatitis has been reported to be very rare. We reported a case of pulmonary embolism ...
Molitch Mark E - - 2012
There is a clinical impression that when tumors invade the cavernous sinus, compression of the internal carotid artery is rare with pituitary adenomas and more common with other types of lesions but there are no actual data to support this impression. To confirm the impression that the finding of internal ...
Tsuji Yoshihiko - - 2012
Pancreatic surgery concomitant with abdominal aortic repair is rarely chosen due to concerns about prosthetic infection following pancreatic leakage and the poor prognosis of pancreatic neoplasms. We herein report a successfully treated case of infrarenal abdominal aortic aneurysm and intraductal papillary mucinous neoplasms of the pancreas treated by a one-stage ...
Frösen Juhana - - 2012
Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial arteries that develop when the cerebral artery wall becomes too weak to resist hemodynamic pressure and distends. Some sIAs remain stable over time, but in others mural cells die, the matrix degenerates, and eventually the wall ruptures, causing life-threatening hemorrhage. ...
Rennert J - - 2012
Fenestrations and duplications of the cervical and intracranial arteries are rare anatomic variants, reported to be associated with aneurysms or other vascular anomalies. We here present a patient with a supraclinoid ICA fenestration in combination with a duplication of the MCA originating from the ICA fenestration and an associated aneurysm.
Evonich Rudolph F - - 2012
BACKGROUND: Due to the variable anatomy of the human pulmonary vein (PV), PV isolation for atrial fibrillation ablation is challenging. A novel hot balloon ablation catheter has been developed to improve ablation outcomes. The efficacy, histopathologic lesion characteristics, and thermodynamics of this technology were examined. METHODS: Swine underwent left atrial ...
Singh M - - 2012
Vascular Ehlers-Danlos Syndrome (EDS) is a rare autosomal dominant condition resulting from a defect in type III procollagen synthesis. This causes the development of severe vascular pathologies, including arterial rupture and pseudoaneurysm formation. We present a case of a young boy previously diagnosed with vascular EDS due to a Gly975Val ...
Hu Yijie - - 2012
Unruptured aneurysm of the sinus of Valsalva is a rare abnormality. In the present case, the huge aneurysm of the sinus of Valsalva was only involved in the right coronary sinus with the ostium far from its normal place. We designed a modified repair technique, with a scalloped Intergard woven ...
Matsuyama Yumi - - 2012
We present a case of a female patient with reversible cerebral vasoconstriction syndrome (RCVS) arising after receiving subcutaneous injection of human placenta extract. A 44-year-old woman started taking human placenta extract with the aim of improving her menopausal symptoms, fatigue, and beauty. However, 18 days after taking human placenta extract, ...
La Spina P - - 2012
Although the association between PFO and cryptogenic stroke is well shown in young adults, the causality is still unclear. The pathogenetic mechanism of ischemic stroke related to PFO is not entirely understood. Indeed, besides the well-known paradoxical embolism, formations of thrombi in situ, especially in the presence of ASA, a ...
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